333 results on '"Mohassel P"'
Search Results
102. P.08 Phase 1 open-label trial of Rycal S48168 (ARM210) for RYR1-related myopathies
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Todd, J., primary, Lawal, T., additional, Chrismer, I., additional, Kokkinis, A., additional, Grunseich, C., additional, Jain, M., additional, Waite, M., additional, Barnes, M., additional, Biancavilla, V., additional, Pocock, S., additional, Brooks, K., additional, Reikof, W., additional, Emile-Backer, M., additional, Marks, A., additional, Webb, Y., additional, Marcantonio, E., additional, Foley, A., additional, Meilleur, K., additional, Bönnemann, C., additional, and Mohassel, P., additional
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- 2022
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103. O.10 First-in-human intrathecal gene transfer study for giant axonal neuropathy: Preliminary review of long-term efficacy and safety
- Author
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Bharucha-Goebel, D., primary, Saade, D., additional, Todd, J., additional, Norato, G., additional, Jain, M., additional, Waite, M., additional, Armao, D., additional, Foley, A., additional, Lehky, T., additional, Averion, G., additional, Hu, Y., additional, Mohassel, P., additional, Hoke, A., additional, DeLong, T., additional, Acquaye, N., additional, Hinkley, L., additional, Chichester, J., additional, Mendoza, C., additional, Soldatos, A., additional, Gray, S., additional, and Bönnemann, C., additional
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- 2022
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104. P.155 Recurring homozygous ACTN2 variant (p.Arg506Gly) cause a recessive, adult-onset myofibrillar myopathy
- Author
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Donkervoort, S., primary, Mohassel, P., additional, O'Leary, M., additional, Hartley, T., additional, Mozaffar, T., additional, Saporta, M., additional, Dyment, D., additional, Austin-Tse, C., additional, Verma, S., additional, Hurth, K., additional, Warman-Chardon, J., additional, O'Donnell-Luria, A., additional, and Bönnemann, C., additional
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- 2022
- Full Text
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105. I.08 Motor neuron disease caused by excess sphingolipid synthesis
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Mohassel, P., primary, Dunn, T., additional, and Bönnemann, C., additional
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- 2022
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106. Evaluation of Broadleaf Weeds Control with Selectivity of Post-Emergence Herbicides in Sugar Beet (Beta vulgaris L.)
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Ali Asghar CHITBAND, Reza GHORBANI, Mohammad Hassan RASHED MOHASSEL, Majid ABBASPOOR, and Rahmat ABBASI
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Agriculture (General) ,S1-972 ,Science (General) ,Q1-390 - Abstract
The reduction of herbicide applications is a main research priority in recent years. In order to study the effect of individual post-emergence application of sugar beet broad-leaf herbicides at four to six true-leaf stage of weeds, experiments were conducted during 2013. Treatments included untreated control and several rates of desmedipham + phenmedipham + ethofumesate, chloridazon and clopyralid on Portulaca oleracea, Solanum nigrum, Amaranthus retroflexus and Chenopodium album. A completely randomized layout with three replications was used for each herbicide. Three weeks after spraying (WAS), plants were harvested and measured their dry weight. These herbicides were more effective to control Portulaca oleracea than other weeds, thereupon minimum dose required for a satisfactory efficacy of 90% reduction of Portulaca oleracea aboveground dry matter (ED90) were 299.22, 1138.31 and 129.44 g a.i ha-1 of desmedipham + phenmedipham + ethofumesate, chloridazon and clopyralid, respectively. Solanum nigrum was more affected by clopyralid application (132.40 g a.i ha-1), and did not make significant difference in Portulaca oleracea. Chloridazon had lower effect for control of Chenopodium album due to existence of powdery covering on abaxial side of the leaves. Biomass ED50 or ED90, based on log-logistic dose–response curves, for Chenopodium album was considerably higher than other species. These results showed that tank mixtures with other herbicides may be required for satisfactory weed control and reduction in applied herbicides doses.
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- 2014
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107. Effect of Simulated Radiation on Sethoxydim Performance Used with and without Vegetable Oils
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Hossein HAMMAMI, Mohammad Hassan RASHED MOHASSEL, Mehdi PARSA, Mohammad BANNAYAN-AVAL, and Eskandar ZAND
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Agriculture (General) ,S1-972 ,Science (General) ,Q1-390 - Abstract
The photodecomposition of post emergence herbicides on leaf surface can be affected via adding vegetable oils to spray tank. Nine vegetable oils were compared to assess the photodecomposition of sethoxydim on wild oat leaf surface under simulated light conditions. The experiment was conducted as completely randomized factorial design with three replications at the College of Agriculture, Ferdowsi University of Mashhad, Iran, in 2013. Each herbicidal solution (with and without vegetable oil) was exposed to simulated light at 0, 5, 10, 20, 30, 60, 120 and 240 MAS (min after spray), for 30 min. The performance of sethoxydim in the presence of turnip, olive, soybean, corn, sunflower, canola, sesame, castor and cotton seed oils, compared to non-vegetable oil solution, increased up to 4.02-, 3.44-, 3.22-, 3.08-, 2.86-, 2.09-, 1.96-, 1.77- and 1.25- fold. All vegetable oils significantly improved the resistance of sethoxydim to light treatment. The effect of vegetable oils on the resistance to photodecomposition of sethoxydim was significant different at less than 60 MAS, while no significant differences were noted among vegetable oils when light treatment occurred at 120 and 240 MAS. Data from the light treatments have confirmed that when vegetable oils were added to sethoxydim, light adverse effect was lower, which is presumably due to disturbance of the cuticule and the rapid absorption of sethoxydim by wild oat leaves. Vegetable oils fatty acids composition effect the resistance to photodecomposition of sethoxydim, as with increasing the unsaturated fatty acid values, the resistance to photodecomposition was improved.
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- 2014
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108. The Chirality Parameter for Chiral Chemical Solutions
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Mohammadi-Baghaee, Reza and Rashed-Mohassel, Jalil
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- 2016
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109. Overcoming Hard Water Antagonistic to Glyphosate or Imazethapyr with Water Conditioners
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Akbar ALIVERDI, Ali GANBARI, Mohammad-Hassan RASHED MOHASSEL, Mehdi NASSIRI-MAHALLATI, and Eskandar ZAND
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Agriculture (General) ,S1-972 ,Science (General) ,Q1-390 - Abstract
Carrier water quality may affect the activity of weak acid herbicides when concentrations of some cations are high. A dose-response experiment on glyphosate and imazethapyr activity, which were carried by the carrier types of distilled water and hard water, against jimsonweed were conducted to compare the water conditioning chemicals ammonium sulfate, ammonium nitrate, citric acid and potassium phosphate, with magnetized carrier as a new method. A magnetic field of 0.7 Tesla was applied to prepare the magnetized carrier. With the exception of potassium phosphate with imazethapyr, the activity of glyphosate and imazethapyr was significantly increased in the presence of the water conditioning methods when distilled water was used as the carrier. Ammonium sulfate was the most effective method. The activity of both herbicides was decreased when applied with hard water carrier. Potassium phosphate was not effective at reducing the antagonism of cations in the hard water carrier. In glyphosate, the performance of water conditioning methods in softening hard water carrier could be ranked as follows: ammonium sulfate (2.52-fold) > magnetized carrier (2.12-fold) ≥ citric acid (1.64-fold) ≥ ammonium nitrate (1.39-fold) > potassium phosphate (0.96-fold). In imazethapyr, this order was as follows: ammonium sulfate (2.99-fold) > ammonium nitrate (2.66-fold) > magnetized carrier (1.81-fold) ≥ citric acid (1.64-fold) > potassium phosphate (1.10-fold).
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- 2014
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110. Comparison of Bacterial Leakage between 3 Different Root Canal Obturation Techniques in Oval Shaped Canals
- Author
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Eshagh-ali Saberi, Shahram Shahraki, Sediqe Ebrahimipour, Anousheh Rashed Mohassel, Narjes Akbari, and Majid Rezaei
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Bacterial leakage ,lateral condensation ,obtura ,oval canal ,warm vertical condensation ,Dentistry ,RK1-715 - Abstract
Introduction: The purpose of this study was to evaluate the sealing ability of 3 obturation techniques in oval-shaped canals by bacterial leakage assessment. Methods: Sixty mandibular incisors with oval canals were selected after providing buccolingual and mesiodistal radiographs. The teeth were sectioned at a 10 mm distance from the apex. After instrumentation, the teeth were divided into 3 groups and the canals in the three groups were obturated with lateral condensation (G1), warm vertical condensation (G2) and thermoplasticized injectable gutta percha (G3). The teeth were exposed to human saliva. Observing the turbidity of the BHI broth for a period of 63 days the number of days required for the complete contamination of root canals was recorded. The data were analyzed using descriptive statistical methods and Kruskal-Wallis test with SPSS statistical software. Results: Warm vertical condensation (G2) needed a significantly greater average time for leakage than the two other methods. No significant differences were found between lateral condensations and thermoplasticized injectable G.P techniques. Conclusion: warm vertical condensation provides a better seal against bacterial leakage than lateral condensation and obtura II method in obturating oval-canals.
- Published
- 2014
111. Effects of weed management strategies on weed density and biomass and saffron (Crocus sativus) yield
- Author
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Hossein Zare Hosseini, Reza Ghorbani, Mohammad Hassan Rashed Mohassel, and Hossein Rahimi
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Barely ,Cover crop ,Hand weeding ,herbicide ,Mulch ,Saffron stigma ,Agriculture (General) ,S1-972 ,Agricultural industries ,HD9000-9495 - Abstract
In order to study and compare chemical and non-chemical methods of weed management in saffron (Crocus sativus) fields, two field experiments were carried out in a randomized completely block design with three replications at Research Field Station of Gonabad during 2009 to 2011. Treatments included cover crops of barely, Mushroom bed mulch, herbicides of haloxyfop R methyl ester (EC10%), iodosulfuron methyl sodium+mesosulfuron. methyl + mefenpyr. diethy (WG6%) l, hand weeding (DF75%) and control. For determining the ability of treatments for weed control, dry matter of weed, leaf dry weight of saffron, stigma and saffron flower yields were determined. Results showed that dominant weed species were mouse barely (Hordeum murinum), wild barley (Hordeum spontaneum) Hoary cress (Cardaria draba), and yarrow (Achillea millefolium). Herbicides of iodosulfuron methyl sodium + mesosulfuron methyl + mefen pyr. Diethy (WG6%) destroyed grasses and broadleaf, but it destroyed saffron plant too. Haloxyfop. R methyl ester damaged grasses but decreased stigma yield and leaf of saffron. Applied mulch was not be able to control the weeds, however, it increased saffron stigma yield. Cover crops of barley significantly decreased weed dry matter weights. Barley caused least weeds dry matter weight similar to hand weeding. In conclusion, the treatments of cover crops showed the best performances in weed control and saffron yield comparing to other studied weed management methods.
- Published
- 2014
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112. Evaluation the Effect of Water Quality and Soil Nitrogen Content on Glyphosate Efficacy on Common Lambsquart(Chenopodium album L.) control
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M. Azad, E. Izadi-Darbandi, and M. H. Rashed Mohassel
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Calcium carbonate ,Dry mater ,Herbicide ,Water hardness. ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
In order to study the effect of soil nitrogen content and water hardness on glyphosate efficacy on common lambsquart control, an experiment was carried out as a completely randomized design in a factorial arrangement with three replications in 2011 at the College of Agriculture, Ferdowsi University of Mashhad. Experimental treatments were included soil nitrogen content at 5 levels (0, 50, 90, 200 and 300 mg/kg soil), glyphosate doses at 7 levels (0, 75, 100, 125, 150, 175 and 200 % dose guideline glyphosate for common lambsquart), calcium carbonate concentration in water as index of water hardness at 5 levels ( 0, 100, 300, 600 and 1200 ppm). Spray was done at 8-10 common lambsquart leaf stage. 30 days after glyphosate spray, plants survival and shoot dry matter was measured. Results showed, herbicide rate, soil nitrogen content and water hardness had significantly affect (P
- Published
- 2014
113. Behavior of Sethoxydim Alone or in Combination with Turnip Oils on Chlorophyll Fluorescence Parameter
- Author
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Hossein HAMMAMI, Mohammad Hassan RASHED MOHASSEL, Mehdi PARSA, Mohammad BANNAYAN-AVAL, and Eskandar ZAND
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Agriculture (General) ,S1-972 ,Science (General) ,Q1-390 - Abstract
Sethoxydim is an acetyl-coenzyme A carboxylase (ACCase) inhibitor that changed the shape of the chlorophyll fluorescence curve (kautsky curve) in wild oat (Avena ludoviciana Durieu.) in greenhouse experiment. This experiment was conducted as completely randomized factorial design with three replications at the College of Agriculture, Ferdowsi University of Mashhad, Iran, during 2012. Results of this study revealed that sethoxydim only and plus emulsifiable turnip oil changed the shape of the chlorophyll fluorescence curve (kautsky curve) 7 days after spraying. Sethoxydim plus emulsifiable turnip oil changed the shape of the kautsky curve more than for sethoxydim only. We found that in our study the fv/fm (maximum quantum efficiency) was closely linked to the fresh and dry weight dose-response. Sethoxydim plus emulsifiable turnip oil proved more rapidly effect on fv/fm in comparison with sethoxydim only. The fresh and dry weight dose-response relationship with fv/fm showed a similar behavior. This study revealed a good relation between fresh and dry weight according with values of 28 DAS and fv/fm 7 DAS. In general, the findings of this study revealed that Fv/Fm is a good parameter for evaluating effect of sethoxydim little time after spraying. Also, this research showed that 4 folds more time for classical screening methods comparing to chlorophyll fluorescence method. Thereupon, classical screening methods may be replaced by chlorophyll fluorescence method in future.
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- 2014
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114. Phenological characteristics of the invasive weed Cucumis melo
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Sohrabi, Sima, Ghanbari, Ali, Mohassel, Mohammad Hassan Rashed, and Gherekhloo, Javid
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growth ,monoeclous ,monoecious plants ,reproduction ,wild melon ,Agriculture ,Botany ,QK1-989 - Abstract
Phenology is the study of periodic biological events. The time of weed appearance, growth and reproduction are very important for decisions on invasive weed management. Cucumis melo is an annual invasive weed of soybean fields in the north of Iran that reproduces and spreads predominately through seed production. In order to study the phenology of wild melon was conducted an experiment in CRD at Research Farm of Gorgan University of Agricultural Sciences and Natural Resources, Iran, during 2012. Seeds first germinated after 10 days of planting, as soon as optimal soil temperatures were achieved. The weed exhibited monoecious tendencies, with production of male flowers rapidly followed by production of both male and female flowers on the same vine. Cucumis melo exhibited prolific fruit production, until senescence occurred at 75 and 92 days after establishment. First fruit formation was observed between 40 and 49 days after emergence, depending on temperature. To complete growth cycle, of Cucumis melo required about 448 and 733 degree days, respectively for late of May and 8 of June. The weed produced a maximum of 100 fruits/plant, but an average plant typically produced 48 fruits/plant. The seed number and seed weight was on average about 190 seeds/fruit and 0.55 g per 100 seeds, respectively. The results indicated that wild melon could produce a lot of fruits and seeds within a growth period of about 75 and 92 days.
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- 2014
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115. Effect of desiccation and salinity stress on seed germination and initial plant growth of Cucumis melo
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S. Sohrabikertabad, A. Ghanbari, H.R. Mohassel, Mohamad, M.N. Mahalati, and J. Gherekhloo
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germination ,Osmotic potential ,Cucurbitaceae ,Seedling vigor index (SVL) ,Biology (General) ,QH301-705.5 ,Botany ,QK1-989 - Abstract
Smellmelon, an annual invasive weed of soybean production fields in the north of Iran, reproduces and spreads predominately through seed production. This makes seed bank survival and successful germination essential steps in the invasive process. To evaluate the potential of Smellmelon to invade water-stressed environments, laboratory studies were conducted to investigate the effect of desiccation and salinity at different temperatures on seed germination and seedling growth of Cucumis melo. Seeds were incubated at 25, 30, 35 and 40 ºC in the darkness in a solution (0, -0.2, -0.4, -0.6, -0.8, 1 and 1.2 MPa) of a salt (NaCl), and in a solution (0, -2, -4, -6, -8, -10, -12 bar) of PEG-6000 (Polyethylene glycol), in two separate experiments. The results showed that the highest percentage and rate of germination occurred at 35 ºC in salt concentrations of 0, -0.2, -0.4 MPa and PEG concentrations of 0, -2, -4 bar. Increasing the concentration of salt (NaCl) and PEG limited germination, seedling growth and water uptake but increased the sodium content in the seedlings. No significant difference was observed among 0, -0.2 and -0.4 MPa of NaCl and among 0, -2 and -4 bar of PEG concentration at 35 ºC. The negative effects of PEG were more than those of NaCl on germination percentage and germination rate. Increased stress levels lead to reduction of root and shoot length, and SVL of seedlings. Na+ content of seedling decreased with limited seedling growth of C. melo.
- Published
- 2013
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116. The Relationship between Birth Weight, Birth Height, and Dental Development by Demirjian’s Method
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Shakiba Afzalinasab, Anousheh Rashed Mohassel, and Najmeh Anbiaee
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Birth weight ,dental development ,panoramic ,Dentistry ,RK1-715 - Abstract
Introduction: Like other measures of human development, dental development is not in complete accordance to chronological age. Investigations show that dental age can be affected by gender, race, systemic conditions, and some other factors and consequently, be different in people of the same chronological age. A correct estimation of dental age and its development in children is of great importance to design the appropriate dental treatment plan. One of the factors predicted to influence dental development is the physical status of newborn, of which, the most common indices are birth weight and height. The aim of this study was to evaluate the effects of these two factors on the dental development of permanent teeth in children of both genders. Methods: The dental ages of 211 of 4-14 year old healthy children were calculated using their panoramic radiographs according to Demirjian’s method. Birth weight, height, and date were recorded from the vaccination certificate. The dental development rate was obtained by subtracting chronological age from dental age. Pearson correlation tests and regression analysis were conducted in both genders. Results: the correlation between dental development and birth weight and birth height was positive, when separated by gender; this correlation was only significant among females. Conclusion: There is a positive relationship between physical status of newborn and the development of permanent teeth. This should be taken into consideration when designing dental treatment plans for children.
- Published
- 2013
117. Some biological aspects of the weed Lesser celandine (Ranunculus ficaria)
- Author
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S. Sohrabi Kertabad, M.H. Rashed Mohassel, M. Nasiri Mahalati, and J. Gherekhloo
- Subjects
freezing ,germination ,osmotic potential ,tuberous root ,Biology (General) ,QH301-705.5 ,Botany ,QK1-989 - Abstract
Lesser celandine (Ranunculaceae) is a perennial weed with tuberous root. Tubers are the most important means of reproduction and dispersion of this weed. In recent years, it has spread into wheat fields in Western Iran, mainly in the Lorestan province. A series of experiments were conducted to determine cardinal temperatures and to study the effects of pre-chilling, temperature fluctuations, tuber size, freezing and drying on germination of the tubers, as well as the effect of planting depth on sprouting of the tubers. The results obtained showed that the highest percentage of germination occurred when tubers were stored for more than 2 weeks at 4 or 8 ºC. The optimum temperature for germination differed in large and small tubers (8 and 14oC, respectively). Germination was the highest (almost 100%) at temperature fluctuations of 5-10oC. Germination of the finger-like and small tubers was the highest (95%); however, very small, small, and broken tubers showed the lowest germination percentage. In the freezing experiment, decreasing the temperature and increasing the storage duration decreased the germination of tubers. Increasing the osmotic potential and temperature resulted in decreased tuber germination of Lesser celandine. Lesser celandine could sprout down to 20 cm depth but heat demand for tubers from superficial depth was smaller than for tubers planted at greater depth.
- Published
- 2013
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118. The Relationship between Birth Weight, Birth Height, and Dental Development by Demirjian’s Method
- Author
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Najmeh Anbiaee, Anousheh Rashed Mohassel, and Shakiba Afzalinasab
- Subjects
birth weight ,dental development ,panoramic ,Dentistry ,RK1-715 - Abstract
Introduction: Like other measures of human development, dental development is not in complete accordance to chronological age. Investigations show that dental age can be affected by gender, race, systemic conditions, and some other factors and consequently, be different in people of the same chronological age. A correct estimation of dental age and its development in children is of great importance to design the appropriate dental treatment plan. One of the factors predicted to influence dental development is the physical status of newborn, of which, the most common indices are birth weight and height. The aim of this study was to evaluate the effects of these two factors on the dental development of permanent teeth in children of both genders. Methods: The dental ages of 211 of 4-14 year old healthy children were calculated using their panoramic radiographs according to Demirjian’s method. Birth weight, height, and date were recorded from the vaccination certificate. The dental development rate was obtained by subtracting chronological age from dental age. Pearson correlation tests and regression analysis were conducted in both genders. Results: the correlation between dental development and birth weight and birth height was positive, when separated by gender; this correlation was only significant among females. Conclusion: There is a positive relationship between physical status of newborn and the development of permanent teeth. This should be taken into consideration when designing dental treatment plans for children
- Published
- 2013
119. The Relationship between Body Mass Index and Dental Development by Demirjian's Method in 4- to 15-Year-Old Children in Mashhad The Relationship between Body Mass Index and Dental Development by Demirjian's Method in 4- to 15-Year-Old Children in Mashhad
- Author
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Najmeh Anbiaee, Anousheh Rashed Mohassel, and Ali Bagherpour
- Subjects
Body mass index ,Dental development ,Panoramic ,Dentistry ,RK1-715 - Abstract
Introduction: The purpose of this study was to evaluate the relationship between the body mass index (BMI) and dental development. Methods: The dental ages of 196 children were calculated according to Demirjian’s method. The chronological age, weight, and height were recorded. Dental development was defined as dental age minus chronological age. Children were classified into three groups according to their BMI: underweight, normal, or overweight and obese. We used One-way analysis of variance (ANOVA), and Pearson correlation tests to analyze the data (significance level of 0.05). Results: There was a significant correlation between BMI and dental development in the girls (P=0.03, r=0.205). There was not a significant correlation between BMI and dental development in the boys (P=0.08, r=0.18). There was not a significant difference between the mean dental development and BMI group in the girls (P=0.07). There was a significant difference between mean dental development in different BMI groups in the boys (P=0.018). Conclusion: Dental development in overweight and obese boys is significantly accelerated
- Published
- 2013
120. The Effect of Relative Emergence Time and Density of Common Lambsquarters (Chenopodium album L.) on Corn (Zea mays L.) Grain and Biological Yield
- Author
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v Sarabi, m Nassiri Mahallati, A Nezami, and m.h Rashed Mohassel
- Subjects
Plant culture ,SB1-1110 ,Agriculture (General) ,S1-972 - Abstract
Abstract To study the effect of competitive potential of corn (Zea mays), in competition with common lambsquarters (Chenopodium album) an experiment was conducted in 2006, at the farm of Agricultural Faculty of Ferdowsi University. In this experiment the effect of relative emergence time of common lambsquarters on single Cross 704 corn yield was studied in different densitis of the weed. The experimental design was split plot based on randomized completed block design with three replications. The emergence time at 3 levels (emergence of the weed 14 days earlier, 7 days earlier and simultaneously with corn) was considered as main plots and density of weed at 6 levels (0, 4, 8, 12, 16 and 20 plants m-2) as sub plots. The results showed a decrease in grain and biological yield of corn, as the emergence time of corn delayed in comparison with the emergence time of weed. The maximum yield reduction of 100 and 99% was observed respectively, in the earliest emergence time of common lambsquarters compared to corn and in the highest density of weed (20 plants m-2) where the corn plants were fully shaded by the weed canopy and no ear was produced. The yield loss of corn was higher when the earlier emergence time of weed was occurred in higher weed densities. based on the results of this research it can be concluded that the decrease of competitive potential of corn with increasing the relative emergence time of common lambsquarters was led to significant yield loss of corn crop. While the increase in weed density resulted in corn yield reduction, there was no difference in yield loss in high weed densities. Keywords: Biomass, Competition, Weed interference model, Yield loss
- Published
- 2011
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121. Study of Allelopathic Potential of Soybean (Glysine max) on Seed Germination and Seedling Growth of Some Weed Speciesand Seedling Growth of Some Weed Species
- Author
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E Elahifard and mH Rashed Mohassel
- Subjects
Plant culture ,SB1-1110 ,Agriculture (General) ,S1-972 - Abstract
Abstract An experiment was conducted for evaluation the allelopathic potential of extract soybean shoot on seed germination and seedling growth of four weed species tumble pigweed, smooth pigweed, common lambsqurters and black nightshade. For each species a factorial experiment was used in a completely randomized design with three replications. Plant shoots were gathered in flowering stage and individually dried and then ground. Water extracts with concentrations of 5, 10, 20 and 40 % were prepared and distilled water was used as control. Seeds of weed sat in petri dishes. Then, their germination percentage determined after 11 days. The results showed that root length, germination rate and percentage reduced in weed species when concentration rate was increased. Black nightshade had most germination percentage (88.14), root length (46.4 mm) and germination uniformity (1.5 days). Therefore, it affected with soybean shoot extract less than other weed species. Tumble pigweed had most germination rate (3 days) and its required time to achieved 10, 50 and 90% maximum germination, was about 2, 2.5 and 4 days respectively. Therefore, It was better than other species. Most inhibition effect of extracts on germination percentage belonged to smooth pigweed. Keywords: Germination percent, Germination rate, Germination uniformity, Radicle length
- Published
- 2011
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122. Planting depth and rhizome size effects on below ground growth of licorice (Glycyrrhiza glabra L.)
- Author
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reza vali allah poor, mohamad hasan rashe mohassel, and ali ghanbari
- Subjects
Plant culture ,SB1-1110 ,Agriculture (General) ,S1-972 - Abstract
An experiment was carried out to evaluate the effects of planting depth and rhizome sizes on below ground growth of licorice (Glycyrrhiza glabra L.) at research glasshouse of Mashhad Unversity in 2001. Factorial experiment containing 2 factors of planting depth (10, 20 and 40cm) and rhizome sizes (1,2 and 3 buds or 4,7 and 10 gr) with two replications in completely randomized block design was employed. Development of different variables during growing season including root and mother rhizome dry weight were measured.The highest and the lowest root dry weight (RDW)have been seen in depth of 20 and 40 cm, respectively. About 100 days after planting (DAP), RDW increaseed very slowly but thenafter increased faster. Rhizome of any sizes in 20 cm, gave the highest RDW. Three-bud rhizomes produced the highest RDW and 1-bud rhizome produced the lowest. Mother rhizome dry weight (MRDW) reduced untill 60 days after planting. After 75th day, MRDW has increased and all plants started to fill their mother rhizome and finally rhizome of depth 20 cm produced the highest dry weight. In 160 days after planting, mother rhizomes started to lose their weight. 1and 3 -bud mother rhizome produce the lowest and highest MRDW, respectively.
- Published
- 2009
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123. Seasonal Parasitism and Hyperparasitism of Walnut Aphid, Chromaphis juglandicola (Hom.: Aphididae ) in Tehran Province
- Author
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E. Rakhshani, A.A. Talebi, S.E. Sadeghi, N.G. Kavallieratos, and A. Rashed Mohassel
- Subjects
Veterinary medicine ,SF600-1100 - Published
- 2004
124. Biology of Macrosiphoniella sanborni ( Hom.: Aphididae )on Chrysanthemum in Field and Laboratory Conditions
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A. Rashed Mohassel, K. Kamali, A. Rezvani, and Y. Fathipour
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Veterinary medicine ,SF600-1100 - Published
- 2004
125. COLLAGEN RELATED MUSCLE DISEASES
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Syeda, S., primary, Mohammed, M., additional, Foley, A., additional, Donkervoort, S., additional, Saade, D., additional, Neuhaus, S., additional, Mohassel, P., additional, Bharucha-Goebel, D., additional, Leach, M., additional, Fink, M., additional, Dastgir, J., additional, and Bönnemann, C., additional
- Published
- 2021
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126. NEW GENES, NEW TECHNIQUES IN NEUROMUSCULAR DISORDERS
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Mohassel, P., primary, Donkervoort, S., additional, Lone, M., additional, Nalls, M., additional, Gable, K., additional, Gupta, S., additional, Foley, A., additional, Hornemann, T., additional, Dunn, T., additional, and Bönnemann, C., additional
- Published
- 2021
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127. COLLAGEN RELATED MUSCLE DISEASES
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Mohammed, M., primary, Syeda, S., additional, Foley, A., additional, Donkervoort, S., additional, Neuhaus, S., additional, Saade, D., additional, Mohassel, P., additional, Bharucha-Goebel, D., additional, Leach, M., additional, Meilleur, K., additional, Fink, M., additional, Iannaccone, S., additional, Konersman, C., additional, and Bönnemann, C., additional
- Published
- 2021
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128. Estimate of trifluralin half-life in soil by bioassay experiment
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majid barzoei, E. Izadi-Darbandi, m Rashed Mohassel, m Rastgoo, and m Hassanzadeh
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Bioassay, Half-life, Trifluralin, sorghum ,Agriculture (General) ,S1-972 - Abstract
This study was conducted to investigate the effect of organic and bio-fertilizers on trifluralin durability.Herbicide persistence is an important consideration in crop production since residue levels of trifluralin herbicides can persist to the next growing season and may injure sensitive crops in the rotation. Residues of trifluralin persist in the soil for long periods. Extremely small amounts of resides can be devastating to some crops that are planted in the following year. Bioassay experirent is a common and cheaper experiment for herbicide residue detection in soil.In order to estimation of trifluraline halfe life in soila field experiment conducted as a factorial arrangement in completely randomized block designwith 3 replications. Experimental factor included two levels of trifluraline (EC %48) application rate480 and 960 g.Ha-1 a.i.). For determination of trifluralin residue, soil sampling was taken from 0 to 10 cm soil dept at 0, 3, 7, 15, 30, 60, 90 and 120 days after spraying. soil sampling and soil treatments were transferred to the greenhouse. The results of Bioassay experiment with sorghum plants showed decreasing trifluralin durability with the application of organic and biological fertilizer. The highest half life were observed (144 and 130 days), by using 480 g. a.i/ha related to shoot and root biomass and no fertilizer application respectively and the Least a half-life was in shoot biomass related to organic fertilizer treatment (18 and 19 days) and 480 and 960 g trifluralin active ingredient.
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- 2016
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129. Endodontic Treatment of Fused Teeth with Talon Cusp
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Shima Sadat Miri, Hakimeh Ghorbani, and Anousheh Rashed Mohassel
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Dentistry ,RK1-715 - Abstract
Tooth anomalies are rare phenomena that may be reported by patients as chief complaints or may be discovered by dentists in the oral examination. In a few cases, rare anomalies are found together in one mouth. Decision to treat such anomalies depends on whether or not they interfere with function and esthetics and also the patient's preference. In the present case, a 19-year-old male presented with two right maxillary fused central and lateral incisors and a geminated left maxillary central incisor. A talon-like projection was found at the junction site of the fused teeth. His chief complaint was sensitivity to cold at the site of the giant fused tooth. This report describes the process of diagnosis and treatment of the two anomalies according to patient preference and needs.
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- 2014
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130. Compact Microstrip Antenna Structures with Multiband, Broadband, and Band-Notched Properties, for Portable Devices
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Alistair P. Duffy, Mohammad Naser-Moghadasi, Jalil Rashed-Mohassel, and Bal Singh Virdee
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Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Cellular telephone services industry. Wireless telephone industry ,HE9713-9715 - Published
- 2014
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131. Design and Analysis of a New Wide-Band Epsilon Negative Metamaterial for X-Band Applications
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Borazjani, O., Naser Moghadasi, M., Rashed Mohassel, J., and Sadeghzadeh, R. A.
- Abstract
A simple meta-material unit cell with a negative permittivity in the X band is designed in this work. This meta-material cell is a one-sided cell which is simulated to extract scattering parameters, permittivity and permeability. Four different unit cells were examined and simulated to achieve the final structure. The effects of mutual-coupling of unit cells on structural performance were also investigated. Finally, a 7*7 array was constructed from these unit cells. The measurement and simulation results were acceptably consistent. The results show that this structure has a negative refractive index in the frequency range of 9.2–11.7 GHz.
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- 2022
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132. Scatter-free acceleration of particles by interaction with plasma shock waves in the interstellar medium
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Rashed-Mohassel, P, primary and Ghorbanalilu, M, additional
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- 2021
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133. Biallelic loss of function variants in SYT2 cause a treatable congenital onset presynaptic myasthenic syndrome
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Donkervoort, S., Mohassel, P., Laugwitz, L., Zaki, M.S., Kamsteeg, E.J., Maroofian, R., Chao, K.R., Verschuuren-Bemelmans, C.C., Horber, V., Fock, A.J.M., McCarty, R.M., Jain, M.S., Biancavilla, V., McMacken, G., Nalls, M., Voermans, N.C., Elbendary, H.M., Snyder, M., Cai, C., Lehky, T.J., Stanley, V., Iannaccone, S.T., Foley, A.R., Lochmüller, H., Gleeson, J., Houlden, H., Haack, T.B., Horvath, R., Bönnemann, C.G., Donkervoort, S., Mohassel, P., Laugwitz, L., Zaki, M.S., Kamsteeg, E.J., Maroofian, R., Chao, K.R., Verschuuren-Bemelmans, C.C., Horber, V., Fock, A.J.M., McCarty, R.M., Jain, M.S., Biancavilla, V., McMacken, G., Nalls, M., Voermans, N.C., Elbendary, H.M., Snyder, M., Cai, C., Lehky, T.J., Stanley, V., Iannaccone, S.T., Foley, A.R., Lochmüller, H., Gleeson, J., Houlden, H., Haack, T.B., Horvath, R., and Bönnemann, C.G.
- Abstract
Contains fulltext : 229372.pdf (Publisher’s version ) (Closed access), Synaptotagmins are integral synaptic vesicle membrane proteins that function as calcium sensors and regulate neurotransmitter release at the presynaptic nerve terminal. Synaptotagmin-2 (SYT2), is the major isoform expressed at the neuromuscular junction. Recently, dominant missense variants in SYT2 have been reported as a rare cause of distal motor neuropathy and myasthenic syndrome, manifesting with stable or slowly progressive distal weakness of variable severity along with presynaptic NMJ impairment. These variants are thought to have a dominant-negative effect on synaptic vesicle exocytosis, although the precise pathomechanism remains to be elucidated. Here we report seven patients of five families, with biallelic loss of function variants in SYT2, clinically manifesting with a remarkably consistent phenotype of severe congenital onset hypotonia and weakness, with variable degrees of respiratory involvement. Electrodiagnostic findings were consistent with a presynaptic congenital myasthenic syndrome (CMS) in some. Treatment with an acetylcholinesterase inhibitor pursued in three patients showed clinical improvement with increased strength and function. This series further establishes SYT2 as a CMS-disease gene and expands its clinical and genetic spectrum to include recessive loss-of-function variants, manifesting as a severe congenital onset presynaptic CMS with potential treatment implications.
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- 2020
134. Slowly Progressive Limb-Girdle Weakness and HyperCKemia – Limb Girdle Muscular Dystrophy or Anti-3-Hydroxy-3-Methylglutaryl-CoA-Reductase-Myopathy?
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Hiebeler, Miriam, Franke, Raimo, Ingenerf, Maria, Krause, Sabine, Mohassel, Payam, Pak, Katherine, Mammen, Andrew, Schoser, Benedikt, Bönnemann, Carsten G., and Walter, Maggie C.
- Abstract
Anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)-myopathy is a usually rapidly progressive form of immune-mediated necrotizing myopathy (IMNM). Rarer clinical courses show slow progression and resemble the phenotype of limb-girdle dystrophy (LGMD). We demonstrate the difficulties in differentiating LGMD versus anti-HMGCR-myopathy. We report on a 48-year-old patient with slowly progressive tetraparesis and hyperCKemia for more than 20 years. Due to myopathic changes in initial and second muscle biopsy and typical clinical presentation, the patient was diagnosed with LGMD 20 years ago; despite comprehensive genetic testing including exome diagnostics, the genetic cause of disease could not be identified. Finally, HMG-CoA reductase antibodies were detected, confirming the diagnosis of anti-HMGCR-myopathy. By re-work-up of a second muscle biopsy specimen from year 2009, the diagnosis of a IMNM was made in retrospect. Seven cycles of high-dose immunoglobulins were administered; patient reported outcome measures have mildly improved. Patients with clinical LGMD phenotype, degenerative changes in muscle biopsy but without genetic confirmation of the disease should be tested for HMG-CoA-myopathy, thereby allowing for an early start of treatment.
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- 2022
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135. Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With Variants.
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Mohassel, Payam, Chang, Ning N,, Inoue, Kaoru, Delaney, Angela, Hu, Ying, Donkervoort, Sandra, Saade, Dimah, Billioux, B. Jeanne, Meader, Brooke, Volochayev, Rita, Konersman, Chamindra G., Kaindl, Angela M., Cho, Chie-Hee, Russell, Bianca, Rodriguez, Adrian, Foster, K. Wade, Foley, A. Reghan, Moore, Steven A., Jones, Peter L., and Bonnemann, Carsten G.
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- 2022
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136. OUTCOME MEASURES
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Mohassel, P., primary, Gravunder, A., additional, Jain, M., additional, Bulea, T., additional, Damiano, D., additional, Foley, A., additional, and Bönnemann, C., additional
- Published
- 2020
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137. NEW GENES AND DISEASES / NGS & RELATED TECHNIQUES
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Puusepp, S., primary, Reimand, T., additional, Pajusalu, S., additional, Bruels, C., additional, Bönnemann, C., additional, Chao, K., additional, Coppens, S., additional, Donkervoort, S., additional, Goodrich, J., additional, Kang, P., additional, Mohassel, P., additional, Pais, L., additional, Siddique, T., additional, Vargas-Franco, D., additional, Wojcik, M., additional, Stenzel, W., additional, and Ounap, K., additional
- Published
- 2020
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138. NEW GENES IN NEUROMUSCULAR DISEASES
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Mohassel, P., primary, Donkervoort, S., additional, Kim, H., additional, Foley, A., additional, Lornage, X., additional, Foulds, N., additional, Hammans, S., additional, Haack, T., additional, Böhm, J., additional, Tarnopolsky, M., additional, Straub, V., additional, Laporte, J., additional, Muntoni, F., additional, Taylor, J., additional, and Bönnemann, C., additional
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- 2020
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139. CONGENITAL MYOPATHIES 1 – NEMALINE
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Foley, A., primary, Ferranti, S., additional, Saade, D., additional, Mohassel, P., additional, Donkervoort, S., additional, Medne, L., additional, Dastgir, J., additional, Bharucha-Goebel, D., additional, Meilleur, K., additional, Leach, M., additional, Scavina, M., additional, Yum, S., additional, Tennekoon, G., additional, and Bönnemann, C., additional
- Published
- 2020
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140. Particle acceleration by interstellar plasma shock waves in non-uniform background magnetic field
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Rashed-Mohassel, P, primary and Ghorbanalilu, M, additional
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- 2020
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141. Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With SMCHD1Variants
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Mohassel, Payam, Chang, Ning, Inoue, Kaoru, Delaney, Angela, Hu, Ying, Donkervoort, Sandra, Saade, Dimah, Billioux, B. Jeanne, Meader, Brooke, Volochayev, Rita, Konersman, Chamindra G., Kaindl, Angela M., Cho, Chie-Hee, Russell, Bianca, Rodriguez, Adrian, Foster, K. Wade, Foley, A. Reghan, Moore, Steven A., Jones, Peter L., Bonnemann, Carsten G., Jones, Takako, and Shaw, Natalie D.
- Published
- 2022
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142. O.35Disruption of bioavailability of TGFβ in collagen VI-related muscular dystrophy
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Mohassel, P., primary, Rooney, J., additional, Nalls, M., additional, Yun, P., additional, Sleboda, D., additional, Roberts, T., additional, Zou, Y., additional, and Bönnemann, C., additional
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- 2019
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143. P.163Mutations in fast skeletal troponin C (TNNC2) cause contractile dysfunction
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van de Locht, M., primary, de Winter, J., additional, Conijn, S., additional, Ma, W., additional, Helmes, M., additional, Irving, T., additional, Donkervoort, S., additional, Mohassel, P., additional, Medne, L., additional, Quinn, C., additional, Neto, O., additional, Moore, S., additional, Foley, A., additional, Pinto, J., additional, Voermans, N., additional, Bönnemann, C., additional, and Ottenheijm, C., additional
- Published
- 2019
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144. O.9Dominant Collagen XII-related myopathy with a distal myopathy phenotype, amenable to treatment with allele-specific knockdown
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Mohassel, P., primary, Liewluck, T., additional, Hu, Y., additional, Ezzo, D., additional, Saade, D., additional, Neuhaus, S., additional, Bolduc, V., additional, Zou, Y., additional, Donkervoort, S., additional, Medne, L., additional, Sumner, C., additional, Dyck, P., additional, Wierenga, K., additional, Finkel, R., additional, Chen, J., additional, Winder, T., additional, Staff, N., additional, Koch, M., additional, Foley, A., additional, and Bönnemann, C., additional
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- 2019
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145. P.380
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Donkervoort, S., primary, Mohassel, P., additional, Laugwitz, L., additional, Kamsteeg, E., additional, Chao, K., additional, Verschuuren-Bemelmans, C., additional, Horber, V., additional, Fock, J., additional, Voermans, N., additional, Hu, Y., additional, Snyder, M., additional, Iannaccone, S., additional, Lochmüller, H., additional, Haack, T., additional, Foley, A., additional, Horvath, R., additional, and Bönnemann, C., additional
- Published
- 2019
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146. Congenital Titinopathy: Comprehensive characterization and pathogenic insights
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Oates, E.C., Jones, K.J., Donkervoort, S., Charlton, A., Brammah, S., Smith, J.E., Ware, J.S., Yau, K.S., Swanson, L.C., Whiffin, N., Peduto, A.J., Bournazos, A., Waddell, L.B., Farrar, M.A., Sampaio, H.A., Teoh, H.L., Lamont, P.J., Mowat, D., Fitzsimons, R.B., Corbett, A.J., Ryan, M.M., O'Grady, G.L., Sandaradura, S.A., Ghaoui, R., Joshi, H., Marshall, J.L., Nolan, M.A., Kaur, S., Punetha, J., Topf, A., Harris, E., Bakshi, M., Genetti, C.A., Marttila, M., Werlauff, U., Streichenberger, N., Pestronk, A., Mazanti, I., Pinner, J.R., Vuillerot, C., Grosmann, C., Camacho, A., Mohassel, P., Leach, M.E., Foley, A.R., Bharucha-Goebel, D., Collins, J., Connolly, A.M., Gilbreath, H.R., Iannaccone, S.T., Castro, D., Cummings, B.B., Webster, R.I., Lazaro, L., Vissing, J., Coppens, S., Deconinck, N., Luk, H.M., Thomas, N.H., Foulds, N.C., Illingworth, M.A., Ellard, S., McLean, C.A., Phadke, R., Ravenscroft, G., Witting, N., Hackman, P., Richard, I., Cooper, S.T., Kamsteeg, E.J., Hoffman, E.P., Bushby, K., Straub, V., Udd, B., Ferreiro, A., North, K.N., Clarke, N.F., Lek, M., Beggs, A.H., Bonnemann, C.G., MacArthur, D.G., Granzier, H., Davis, M.R., Laing, N.G., Oates, E.C., Jones, K.J., Donkervoort, S., Charlton, A., Brammah, S., Smith, J.E., Ware, J.S., Yau, K.S., Swanson, L.C., Whiffin, N., Peduto, A.J., Bournazos, A., Waddell, L.B., Farrar, M.A., Sampaio, H.A., Teoh, H.L., Lamont, P.J., Mowat, D., Fitzsimons, R.B., Corbett, A.J., Ryan, M.M., O'Grady, G.L., Sandaradura, S.A., Ghaoui, R., Joshi, H., Marshall, J.L., Nolan, M.A., Kaur, S., Punetha, J., Topf, A., Harris, E., Bakshi, M., Genetti, C.A., Marttila, M., Werlauff, U., Streichenberger, N., Pestronk, A., Mazanti, I., Pinner, J.R., Vuillerot, C., Grosmann, C., Camacho, A., Mohassel, P., Leach, M.E., Foley, A.R., Bharucha-Goebel, D., Collins, J., Connolly, A.M., Gilbreath, H.R., Iannaccone, S.T., Castro, D., Cummings, B.B., Webster, R.I., Lazaro, L., Vissing, J., Coppens, S., Deconinck, N., Luk, H.M., Thomas, N.H., Foulds, N.C., Illingworth, M.A., Ellard, S., McLean, C.A., Phadke, R., Ravenscroft, G., Witting, N., Hackman, P., Richard, I., Cooper, S.T., Kamsteeg, E.J., Hoffman, E.P., Bushby, K., Straub, V., Udd, B., Ferreiro, A., North, K.N., Clarke, N.F., Lek, M., Beggs, A.H., Bonnemann, C.G., MacArthur, D.G., Granzier, H., Davis, M.R., and Laing, N.G.
- Abstract
Contains fulltext : 196367.pdf (Publisher’s version ) (Open Access), OBJECTIVE: Comprehensive clinical characterization of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder. METHODS: Using massively parallel sequencing we identified 30 patients from 27 families with 2 pathogenic nonsense, frameshift and/or splice site TTN mutations in trans. We then undertook a detailed analysis of the clinical, histopathological and imaging features of these patients. RESULTS: All patients had prenatal or early onset hypotonia and/or congenital contractures. None had ophthalmoplegia. Scoliosis and respiratory insufficiency typically developed early and progressed rapidly, whereas limb weakness was often slowly progressive, and usually did not prevent independent walking. Cardiac involvement was present in 46% of patients. Relatives of 2 patients had dilated cardiomyopathy. Creatine kinase levels were normal to moderately elevated. Increased fiber size variation, internalized nuclei and cores were common histopathological abnormalities. Cap-like regions, whorled or ring fibers, and mitochondrial accumulations were also observed. Muscle magnetic resonance imaging showed gluteal, hamstring and calf muscle involvement. Western blot analysis showed a near-normal sized titin protein in all samples. The presence of 2 mutations predicted to impact both N2BA and N2B cardiac isoforms appeared to be associated with greatest risk of cardiac involvement. One-third of patients had 1 mutation predicted to impact exons present in fetal skeletal muscle, but not included within the mature skeletal muscle isoform transcript. This strongly suggests developmental isoforms are involved in the pathogenesis of this congenital/early onset disorder. INTERPRETATION: This detailed clinical reference dataset will greatly facilitate diagnostic confirmation and management of patients, and has provided important insights into disease pathogenesis. Ann Neurol 2018;83:1105-1124.
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- 2018
147. Congenital titinopathy: comprehensive characterisation & pathogenic insights
- Author
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Oates, E, Jones, K, Donkervoort, S, Charlton, A, Brammah, S, Smith, J, Ware, J, Yau, K, Swanson, L, Whiffin, N, Peduto, A, Bournazos, A, Waddell, L, Farrar, M, Sampaio, H, Teoh, H, Lamont, P, Mowat, D, Fitzsimmons, R, Corbett, A, Ryan, M, O'Grady, G, Sandaradura, S, Ghaoui, R, Joshi, H, Marshall, J, Nolan, M, Kaur, S, Punetha, J, Topf, A, Harris, E, Bakshi, M, Genetti, C, Marttila, M, Werkauff, U, Streichenberger, N, Pestronk, A, Mazanti, I, Pinner, J, Vuillerot, C, Grosmann, C, Camacho, A, Mohassel, P, Leach, M, Foley, A, Bharucha-Goeber, D, Collins, J, Connolly, A, Gilbreath, H, Iannaccone, S, Castro, D, Cummings, B, Webster, R, Lazaro, L, Vissing, J, Coppens, S, Deconinck, N, Luk, H, Thomas, N, Foulds, N, Illingworth, M, Ellard, S, McLean, C, Phadke, R, Ravenscroft, G, Witting, N, Hackman, P, Clarke, N, Lek, M, Beggs, A, Bonnemann, C, MacArthur, D, Granzier, H, Davis, M, Laing, N, Oates, E, Jones, K, Donkervoort, S, Charlton, A, Brammah, S, Smith, J, Ware, J, Yau, K, Swanson, L, Whiffin, N, Peduto, A, Bournazos, A, Waddell, L, Farrar, M, Sampaio, H, Teoh, H, Lamont, P, Mowat, D, Fitzsimmons, R, Corbett, A, Ryan, M, O'Grady, G, Sandaradura, S, Ghaoui, R, Joshi, H, Marshall, J, Nolan, M, Kaur, S, Punetha, J, Topf, A, Harris, E, Bakshi, M, Genetti, C, Marttila, M, Werkauff, U, Streichenberger, N, Pestronk, A, Mazanti, I, Pinner, J, Vuillerot, C, Grosmann, C, Camacho, A, Mohassel, P, Leach, M, Foley, A, Bharucha-Goeber, D, Collins, J, Connolly, A, Gilbreath, H, Iannaccone, S, Castro, D, Cummings, B, Webster, R, Lazaro, L, Vissing, J, Coppens, S, Deconinck, N, Luk, H, Thomas, N, Foulds, N, Illingworth, M, Ellard, S, McLean, C, Phadke, R, Ravenscroft, G, Witting, N, Hackman, P, Clarke, N, Lek, M, Beggs, A, Bonnemann, C, MacArthur, D, Granzier, H, Davis, M, and Laing, N
- Published
- 2018
148. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration
- Author
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Shashi, V., Magiera, M.M., Klein, D., Zaki, M., Schoch, K., Rudnik-Schoneborn, S., Norman, A., Neto, O. Abath, Dusl, M., Yuan, X., Bartesaghi, L., Marco, P. De, Alfares, A.A., Marom, R., Arold, Stefan T., Guzman-Vega, F.J., Pena, L.D., Smith, E.C., Steinlin, M., Babiker, M.O., Mohassel, P., Foley, A.R., Donkervoort, S., Kaur, R., Ghosh, P.S., Stanley, V., Musaev, D., Nava, C., Mignot, C., Keren, B., Scala, M., Tassano, E., Picco, P., Doneda, P., Fiorillo, C., Issa, M.Y., Alassiri, A., Alahmad, A., Gerard, A., Liu, P, Yang, Y., Ertl-Wagner, B., Kranz, P.G., Wentzensen, I.M., Stucka, R., Stong, N., Allen, A.S., Goldstein, D.B, Schoser, B., Rosler, K.M., Alfadhel, M., Capra, V., Chrast, R., Strom, T.M., Kamsteeg, E.J., Bonnemann, C.G., Gleeson, J.G., Martini, R., Janke, C., Senderek, J., Shashi, V., Magiera, M.M., Klein, D., Zaki, M., Schoch, K., Rudnik-Schoneborn, S., Norman, A., Neto, O. Abath, Dusl, M., Yuan, X., Bartesaghi, L., Marco, P. De, Alfares, A.A., Marom, R., Arold, Stefan T., Guzman-Vega, F.J., Pena, L.D., Smith, E.C., Steinlin, M., Babiker, M.O., Mohassel, P., Foley, A.R., Donkervoort, S., Kaur, R., Ghosh, P.S., Stanley, V., Musaev, D., Nava, C., Mignot, C., Keren, B., Scala, M., Tassano, E., Picco, P., Doneda, P., Fiorillo, C., Issa, M.Y., Alassiri, A., Alahmad, A., Gerard, A., Liu, P, Yang, Y., Ertl-Wagner, B., Kranz, P.G., Wentzensen, I.M., Stucka, R., Stong, N., Allen, A.S., Goldstein, D.B, Schoser, B., Rosler, K.M., Alfadhel, M., Capra, V., Chrast, R., Strom, T.M., Kamsteeg, E.J., Bonnemann, C.G., Gleeson, J.G., Martini, R., Janke, C., and Senderek, J.
- Abstract
Item does not contain fulltext, A set of glutamylases and deglutamylases controls levels of tubulin polyglutamylation, a prominent post-translational modification of neuronal microtubules. Defective tubulin polyglutamylation was first linked to neurodegeneration in the Purkinje cell degeneration (pcd) mouse, which lacks deglutamylase CCP1, displays massive cerebellar atrophy, and accumulates abnormally glutamylated tubulin in degenerating neurons. We found biallelic rare and damaging variants in the gene encoding CCP1 in 13 individuals with infantile-onset neurodegeneration and confirmed the absence of functional CCP1 along with dysregulated tubulin polyglutamylation. The human disease mainly affected the cerebellum, spinal motor neurons, and peripheral nerves. We also demonstrate previously unrecognized peripheral nerve and spinal motor neuron degeneration in pcd mice, which thus recapitulated key features of the human disease. Our findings link human neurodegeneration to tubulin polyglutamylation, entailing this post-translational modification as a potential target for drug development for neurodegenerative disorders.
- Published
- 2018
149. Congenital Titinopathy: Comprehensive characterization and pathogenic insights
- Author
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Oates, EC, Jones, KJ, Donkervoort, S, Charlton, A, Brammah, S, Smith, JE, Ware, JS, Yau, KS, Swanson, LC, Whiffin, N, Peduto, AJ, Bournazos, A, Waddell, LB, Farrar, MA, Sampaio, HA, Teoh, HL, Lamont, PJ, Mowat, D, Fitzsimons, RB, Corbett, AJ, Ryan, MM, O'Grady, GL, Sandaradura, SA, Ghaoui, R, Joshi, H, Marshall, JL, Nolan, MA, Kaur, S, Punetha, J, Toepf, A, Harris, E, Bakshi, M, Genetti, CA, Marttila, M, Werlauff, U, Streichenberger, N, Pestronk, A, Mazanti, I, Pinner, JR, Vuillerot, C, Grosmann, C, Camacho, A, Mohassel, P, Leach, ME, Foley, AR, Bharucha-Goebel, D, Collins, J, Connolly, AM, Gilbreath, HR, Iannaccone, ST, Castro, D, Cummings, BB, Webster, RI, Lazaro, L, Vissing, J, Coppens, S, Deconinck, N, Luk, H-M, Thomas, NH, Foulds, NC, Illingworth, MA, Ellard, S, McLean, CA, Phadke, R, Ravenscroft, G, Witting, N, Hackman, P, Richard, I, Cooper, ST, Kamsteeg, E-J, Hoffman, EP, Bushby, K, Straub, V, Udd, B, Ferreiro, A, North, KN, Clarke, NF, Lek, M, Beggs, AH, Boennemann, CG, MacArthur, DG, Granzier, H, Davis, MR, Laing, NG, Oates, EC, Jones, KJ, Donkervoort, S, Charlton, A, Brammah, S, Smith, JE, Ware, JS, Yau, KS, Swanson, LC, Whiffin, N, Peduto, AJ, Bournazos, A, Waddell, LB, Farrar, MA, Sampaio, HA, Teoh, HL, Lamont, PJ, Mowat, D, Fitzsimons, RB, Corbett, AJ, Ryan, MM, O'Grady, GL, Sandaradura, SA, Ghaoui, R, Joshi, H, Marshall, JL, Nolan, MA, Kaur, S, Punetha, J, Toepf, A, Harris, E, Bakshi, M, Genetti, CA, Marttila, M, Werlauff, U, Streichenberger, N, Pestronk, A, Mazanti, I, Pinner, JR, Vuillerot, C, Grosmann, C, Camacho, A, Mohassel, P, Leach, ME, Foley, AR, Bharucha-Goebel, D, Collins, J, Connolly, AM, Gilbreath, HR, Iannaccone, ST, Castro, D, Cummings, BB, Webster, RI, Lazaro, L, Vissing, J, Coppens, S, Deconinck, N, Luk, H-M, Thomas, NH, Foulds, NC, Illingworth, MA, Ellard, S, McLean, CA, Phadke, R, Ravenscroft, G, Witting, N, Hackman, P, Richard, I, Cooper, ST, Kamsteeg, E-J, Hoffman, EP, Bushby, K, Straub, V, Udd, B, Ferreiro, A, North, KN, Clarke, NF, Lek, M, Beggs, AH, Boennemann, CG, MacArthur, DG, Granzier, H, Davis, MR, and Laing, NG
- Abstract
OBJECTIVE: Comprehensive clinical characterization of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder. METHODS: Using massively parallel sequencing we identified 30 patients from 27 families with 2 pathogenic nonsense, frameshift and/or splice site TTN mutations in trans. We then undertook a detailed analysis of the clinical, histopathological and imaging features of these patients. RESULTS: All patients had prenatal or early onset hypotonia and/or congenital contractures. None had ophthalmoplegia. Scoliosis and respiratory insufficiency typically developed early and progressed rapidly, whereas limb weakness was often slowly progressive, and usually did not prevent independent walking. Cardiac involvement was present in 46% of patients. Relatives of 2 patients had dilated cardiomyopathy. Creatine kinase levels were normal to moderately elevated. Increased fiber size variation, internalized nuclei and cores were common histopathological abnormalities. Cap-like regions, whorled or ring fibers, and mitochondrial accumulations were also observed. Muscle magnetic resonance imaging showed gluteal, hamstring and calf muscle involvement. Western blot analysis showed a near-normal sized titin protein in all samples. The presence of 2 mutations predicted to impact both N2BA and N2B cardiac isoforms appeared to be associated with greatest risk of cardiac involvement. One-third of patients had 1 mutation predicted to impact exons present in fetal skeletal muscle, but not included within the mature skeletal muscle isoform transcript. This strongly suggests developmental isoforms are involved in the pathogenesis of this congenital/early onset disorder. INTERPRETATION: This detailed clinical reference dataset will greatly facilitate diagnostic confirmation and management of patients, and has provided important insights into disease pathogenesis. Ann Neurol 2018;83:1105-1124.
- Published
- 2018
150. Introduction of Pr0.7Sr0.3MnO3/PrMn2O5/Fe3O4/GO nanocomposite as an active compound for hydrogen storage: Step by step synthesis and characterization
- Author
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Mohassel, Reza, Soofivand, Faezeh, Baladi, Mahin, Dawi, Elmuez A., Mahdi, Makarim A., Shabani-Nooshabadi, Mehdi, Jasim, Layth S., and Salavati-Niasari, Masoud
- Abstract
As hydrogen is an alternative to fossil fuels that are hazardous to the environment, this study explores the application of Pr0.7Sr0.3MnO3/PrMn2O5/Fe3O4/graphene oxide (GO) as a potentially effective nanocomposite for the storage of hydrogen. As a means of evaluating the contribution of each component, this nanocomposite was prepared in several stages. Various analyses were conducted to study the effects of Sr, Fe3O4and GO. According to the results, Sr is responsible for increasing the amount of charge carriers that are capable of storing hydrogen. The Sr amount was therefore optimized by altering the calcination temperature. At higher temperatures, there is a reduction in the amount of Sr. In addition, increases in the calcination temperature as well as the presence of Fe3O4may result in mixed metal oxides being formed as a result of thermodynamic reactions. As a result, PrMn2O5became one of the components of the Fe3O4-containing nanocomposites. Upon the presence of Fe3O4, Pr-manganite's magnetic property changed from paramagnetism to super-paramagnetism, and, in addition, magnetization decreased upon the presence of GO. According to electrochemical studies, the anodic peak current of the multi-component composite was 3183.37 μA whereas this was 1126.48 μA for pristine Sr-doped manganite.
- Published
- 2024
- Full Text
- View/download PDF
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