6,873 results on '"Militello, A."'
Search Results
102. ReMKiT1D - A framework for building reactive multi-fluid models of the tokamak scrape-off layer with coupled electron kinetics in 1D.
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Stefan Mijin, Dominic Power, Ryan Holden, William Hornsby, David Moulton, and Fulvio Militello
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- 2024
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103. The Complexity of Tumor Heterogeneity: Limitations and Challenges of the Pharmacogenomics in Cancer Treatment
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Militello, Guglielmo, Bertolaso, Marta, Bertolaso, Marta, Series Editor, and Beneduce, Chiara, editor
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- 2022
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104. Introduction
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Militello, Vincenzo, Spena, Alessandro, Riva Sanseverino, Eleonora, Editor-in-Chief, Amenta, Carlo, Series Editor, Carapezza, Marco, Series Editor, Chiodi, Marcello, Series Editor, Laghi, Andrea, Series Editor, Maresca, Bruno, Series Editor, Micale, Giorgio Domenico Maria, Series Editor, Mocciaro Li Destri, Arabella, Series Editor, Öchsner, Andreas, Series Editor, Piva, Mariacristina, Series Editor, Russo, Antonio, Series Editor, Seel, Norbert M., Series Editor, and Campisi, Giuseppina, editor
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- 2022
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105. The effect of PAMAM dendrimers on the excited states of little-explored xanthene dyes. In search of eco-friendly photoinitiating systems
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Paula Militello, M., Porcal, Gabriela V., Bertolotti, Sonia G., Previtali, Carlos M., and Arbeloa, Ernesto M.
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- 2023
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106. Quantum correlations beyond entanglement in a classical-channel model of gravity
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Federico Roccati, Benedetto Militello, Emilio Fiordilino, Rosario Iaria, Luciano Burderi, Tiziana Di Salvo, and Francesco Ciccarello
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Medicine ,Science - Abstract
Abstract A direct quantization of the Newtonian interaction between two masses is known to establish entanglement, which if detected would witness the quantum nature of the gravitational field. Gravitational interaction is yet compatible also with gravitational decoherence models relying on classical channels, hence unable to create entanglement. Here, we show in paradigmatic cases that, despite the absence of entanglement, a classical-channel model of gravity can still establish quantum correlations in the form of quantum discord between two masses. This is demonstrated for the Kafri–Taylor–Milburn (KTM) model and a recently proposed dissipative extension of this. In both cases, starting from an uncorrelated state, a significant amount of discord is generally created. This eventually decays in the KTM model, while it converges to a small stationary value in its dissipative extension. We also find that initial local squeezing on the state of the masses can significanlty enhance the generated discord.
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- 2022
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107. Correction to: Stem Cells and the Microenvironment: Reciprocity with Asymmetry in Regenerative Medicine
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Militello, Guglielmo and Bertolaso, Marta
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- 2023
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108. Generalized cluster correlation expansion theory for stimulated Raman adiabatic passage processes in the presence of a spin bath
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Fazio, Tommaso, primary, Napoli, Anna, additional, and Militello, Benedetto, additional
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- 2024
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109. NEOPRISM-CRC: Neoadjuvant pembrolizumab stratified to tumour mutation burden for high risk stage 2 or stage 3 deficient-MMR/MSI-high colorectal cancer.
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Shiu, Kai-Keen, primary, Jiang, Yanrong, additional, Saunders, Mark, additional, Seligmann, Jenny F., additional, Iveson, Timothy, additional, Wilson, Richard H., additional, Graham, Janet Shirley, additional, Khan, Khurum Hayat, additional, Militello, Anna-Maria, additional, Irvine, Sandra, additional, Adedoyin, Temi, additional, Begum, Rubina, additional, Bhat, Reshma, additional, Wilson, William, additional, Plumb, Andrew, additional, Obichere, Austin, additional, Rodriguez-Justo, Manuel, additional, and Jansen, Marnix, additional
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- 2024
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110. Epicardial and thoracic subcutaneous fat texture analysis in patients undergoing cardiac CT
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Manfredi Agnese, Patrizia Toia, Giulia Sollami, Carmelo Militello, Leonardo Rundo, Salvatore Vitabile, Erica Maffei, Francesco Agnello, Cesare Gagliardo, Emanuele Grassedonio, Massimo Galia, Filippo Cademartiri, Massimo Midiri, and Ludovico La Grutta
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Epicardial fat ,Texture analysis ,Cardiac computed tomography ,Cardiovascular risk ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Introduction: The aim of our study was to evaluate the feasibility of texture analysis of epicardial fat (EF) and thoracic subcutaneous fat (TSF) in patients undergoing cardiac CT (CCT). Materials and methods: We compared a consecutive population of 30 patients with BMI ≤25 kg/m2 (Group A, 60.6 ± 13.7 years) with a control population of 30 patients with BMI >25 kg/m2 (Group B, 63.3 ± 11 years). A dedicated computer application for quantification of EF and a texture analysis application for the study of EF and TSF were employed. Results: The volume of EF was higher in group B (mean 116.1 cm3 vs. 86.3 cm3, p = 0.014), despite no differences were found neither in terms of mean density (−69.5 ± 5 HU vs. −68 ± 5 HU, p = 0.28), nor in terms of quartiles distribution (Q1, p = 0.83; Q2, p = 0.22, Q3, p = 0.83, Q4, p = 0.34). The discriminating parameters of the histogram class were mean (p = 0.02), 0,1st (p = 0.001), 10th (p = 0.002), and 50th percentiles (p = 0.02). DifVarnc was the discriminating parameter of the co-occurrence matrix class (p = 0.007).The TSF thickness was 15 ± 6 mm in group A and 19.5 ± 5 mm in group B (p = 0.003). The TSF had a mean density of −97 ± 19 HU in group A and −95.8 ± 19 HU in group B (p = 0.75). The discriminating parameters of texture analysis were 10th (p = 0.03), 50th (p = 0.01), 90th percentiles (p = 0.04), S(0,1)SumAverg (p = 0.02), S(1,-1)SumOfSqs (p = 0.02), S(3,0)Contrast (p = 0.03), S(3,0)SumAverg (p = 0.02), S(4,0)SumAverg (p = 0.04), Horzl_RLNonUni (p = 0.02), and Vertl_LngREmph (p = 0.0005). Conclusions: Texture analysis provides distinctive radiomic parameters of EF and TSF. EF and TSF had different radiomic features as the BMI varies.
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- 2023
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111. Prospective Application of the Erythrocyte Sedimentation Rate (ESR) as a Possible Inflammatory Marker in Feline Patients
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Gori, Eleonora, primary, Pasquini, Anna, additional, Paltrinieri, Saverio, additional, Lubas, George, additional, Militello, Carlo, additional, Diamanti, Daniela, additional, Carletti, Carlo, additional, Pantoli, Marianna, additional, and Marchetti, Veronica, additional
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- 2024
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112. Understanding the Dermoscopic Patterns of Basal Cell Carcinoma Using Line-Field Confocal Tomography
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Barbarossa, Lorenzo, primary, D’Onghia, Martina, additional, Cartocci, Alessandra, additional, Suppa, Mariano, additional, Tognetti, Linda, additional, Cappilli, Simone, additional, Peris, Ketty, additional, Perez-Anker, Javiera, additional, Malvehy, Josep, additional, Baldino, Gennaro, additional, Militello, Caterina, additional, Perrot, Jean Luc, additional, Rubegni, Pietro, additional, and Cinotti, Elisa, additional
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- 2024
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113. Physical Activity and Oxidative Stress in Aging
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Militello, Rosamaria, primary, Luti, Simone, additional, Gamberi, Tania, additional, Pellegrino, Alessio, additional, Modesti, Alessandra, additional, and Modesti, Pietro Amedeo, additional
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- 2024
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114. Simulations of the stationary Q = 10 and the exit phase from the flat-top of an ITER 15MA baseline scenario: predictive JINTRAC simulation with a consistent treatment of D and T in the whole plasma
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F. Eriksson, E. Tholerus, G. Corrigan, Y. Baranov, X. Bonnin, D. Farina, L. Figini, L. Garzotti, S.H. Kim, F. Koechl, A. Loarte, E. Militello Asp, C. Olde, V. Parail, S.D. Pinches, A. Polevoi, and P. Strand
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ITER ,integrated modelling ,JINTRAC ,scenario development ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Designing a robust termination scenario for a burning ITER plasma is a challenge that requires extensive core plasma and divertor modelling. The presented work consists of coupled core/edge/SOL/divertor simulations, performed with the JINTRAC code, to study the Q = 10 flat-top phase and exit phase of the ITER 15 MA/5.3 T DT scenario. The modelling utilizes the recently implemented option to treat deuterium and tritium separately in the SOL/divertor, enabling a consistent treatment of deuterium and tritium in the whole plasma volume, which is a unique capability of JINTRAC. In addition, these are the first JINTRAC simulations of this scenario that use a first-principles transport model to self-consistently model the ECRH power deposition and to include tungsten while keeping track of tungsten sputtering and accumulation. The flat-top simulations demonstrate the possibility of sustaining a steady state fusion Q of 10 using pure deuterium gas puffs together with DT mixed pellets, which is an option to make a more effective use of tritium. Simulations of the exit phase are set up sequentially, with each phase providing initial conditions for the next, starting with a density decay at full current and auxiliary power, and demonstrate the possibility of reducing the density robustly within a few seconds. Following the density decay, a subsequent auxiliary power ramp-down in H-mode is performed with a late H–L transition at low auxiliary power, which may provide an option for the optimization of the plasma termination. The final ramp-down phase consists of a current ramp-down in L-mode to 3.75 MA.
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- 2024
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115. Overview of the EUROfusion Tokamak Exploitation programme in support of ITER and DEMO
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E. Joffrin, M. Wischmeier, M. Baruzzo, A. Hakola, A. Kappatou, D. Keeling, B. Labit, E. Tsitrone, N. Vianello, the ASDEX Upgrade Team, JET Contributors, the MAST-U Team, the TCV Team, the WEST Team, the EUROfusion Tokamak Exploitation Team:, D. Abate, J. Adamek, M. Agostini, C. Albert, F.C.P. Albert Devasagayam, S. Aleiferis, E. Alessi, J. Alhage, S. Allan, J. Allcock, M. Alonzo, G. Anastasiou, E. Andersson Sunden, C. Angioni, Y. Anquetin, L. Appel, G.M. Apruzzese, M. Ariola, C. Arnas, J.F. Artaud, W. Arter, O. Asztalos, L. Aucone, M.H. Aumeunier, F. Auriemma, J. Ayllon, E. Aymerich, A. Baciero, F. Bagnato, L. Bähner, F. Bairaktaris, P. Balázs, L. Balbinot, I. Balboa, M. Balden, A. Balestri, M. Baquero Ruiz, T. Barberis, C. Barcellona, O. Bardsley, S. Benkadda, T. Bensadon, E. Bernard, M. Bernert, H. Betar, R. Bianchetti Morales, J. Bielecki, R. Bilato, P. Bilkova, W. Bin, G. Birkenmeier, R. Bisson, P. Blanchard, A. Bleasdale, V. Bobkov, A. Boboc, A. Bock, K. Bogar, P. Bohm, T. Bolzonella, F. Bombarda, N. Bonanomi, L. Boncagni, D. Bonfiglio, R. Bonifetto, M. Bonotto, D. Borodin, I. Borodkina, T.O.S.J. Bosman, C. Bourdelle, C. Bowman, S. Brezinsek, D. Brida, F. Brochard, R. Brunet, D. Brunetti, V. Bruno, R. Buchholz, J. Buermans, H. Bufferand, P. Buratti, A. Burckhart, J. Cai, R. Calado, J. Caloud, S. Cancelli, F. Cani, B. Cannas, M. Cappelli, S. Carcangiu, A. Cardinali, S. Carli, D. Carnevale, M. Carole, M. Carpita, D. Carralero, F. Caruggi, I.S. Carvalho, I. Casiraghi, A. Casolari, F.J. Casson, C. Castaldo, A. Cathey, F. Causa, J. Cavalier, M. Cavedon, J. Cazabonne, M. Cecconello, L. Ceelen, A. Celora, J. Cerovsky, C.D. Challis, R. Chandra, A. Chankin, B. Chapman, H. Chen, M. Chernyshova, A.G. Chiariello, P. Chmielewski, A. Chomiczewska, C. Cianfarani, G. Ciraolo, J. Citrin, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, I.H. Coffey, C. Colandrea, L. Colas, S. Conroy, C. Contre, N.J. Conway, L. Cordaro, Y. Corre, D. Costa, S. Costea, D. Coster, X. Courtois, C. Cowley, T. Craciunescu, G. Croci, A.M. Croitoru, K. Crombe, D.J. Cruz Zabala, G. Cseh, T. Czarski, A. Da Ros, A. Dal Molin, M. Dalla Rosa, Y. Damizia, O. D’Arcangelo, P. David, M. De Angeli, E. De la Cal, E. De La Luna, G. De Tommasi, J. Decker, R. Dejarnac, D. Del Sarto, G. Derks, C. Desgranges, P. Devynck, S. Di Genova, L.E. di Grazia, A. Di Siena, M. Dicorato, M. Diez, M. Dimitrova, T. Dittmar, L. Dittrich, J.J. Domínguez Palacios Durán, P. Donnel, D. Douai, S. Dowson, S. Doyle, M. Dreval, P. Drews, L. Dubus, R. Dumont, D. Dunai, M. Dunne, A. Durif, F. Durodie, G. Durr Legoupil Nicoud, B. Duval, R. Dux, T. Eich, A. Ekedahl, S. Elmore, G. Ericsson, J. Eriksson, B. Eriksson, F. Eriksson, S. Ertmer, A. Escarguel, B. Esposito, T. Estrada, E. Fable, M. Faitsch, N. Fakhrayi Mofrad, A. Fanni, T. Farley, M. Farník, N. Fedorczak, F. Felici, X. Feng, J. Ferreira, D. Ferreira, N. Ferron, O. Fevrier, O. Ficker, A.R. Field, A. Figueiredo, N. Fil, D. Fiorucci, M. Firdaouss, R. Fischer, M. Fitzgerald, M. Flebbe, M. Fontana, J. Fontdecaba Climent, A. Frank, E. Fransson, L. Frassinetti, D. Frigione, S. Futatani, R. Futtersack, S. Gabriellini, D. Gadariya, D. Galassi, K. Galazka, J. Galdon, S. Galeani, D. Gallart, A. Gallo, C. Galperti, M. Gambrioli, S. Garavaglia, J. Garcia, M. Garcia Munoz, J. Gardarein, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, M. Gelfusa, J. Gerardin, S.N. Gerasimov, R. Gerru Miguelanez, G. Gervasini, Z. Ghani, F.M. Ghezzi, G. Ghillardi, L. Giannone, S. Gibson, L. Gil, A. Gillgren, E. Giovannozzi, C. Giroud, G. Giruzzi, T. Gleiter, M. Gobbin, V. Goloborodko, A. González Ganzábal, T. Goodman, V. Gopakumar, G. Gorini, T. Görler, S. Gorno, G. Granucci, D. Greenhouse, G. Grenfell, M. Griener, W. Gromelski, M. Groth, O. Grover, M. Gruca, A. Gude, C. Guillemaut, R. Guirlet, J. Gunn, T. Gyergyek, L. Hagg, J. Hall, C.J. Ham, M. Hamed, T. Happel, G. Harrer, J. Harrison, D. Harting, N.C. Hawkes, P. Heinrich, S. Henderson, P. Hennequin, R. Henriques, S. Heuraux, J. Hidalgo Salaverri, J. Hillairet, J.C. Hillesheim, A. Hjalmarsson, A. Ho, J. Hobirk, E. Hodille, M. Hölzl, M. Hoppe, J. Horacek, N. Horsten, L. Horvath, M. Houry, K. Hromasova, J. Huang, Z. Huang, A. Huber, E. Huett, P. Huynh, A. Iantchenko, M. Imrisek, P. Innocente, C. Ionita Schrittwieser, H. Isliker, P. Ivanova, I. Ivanova Stanik, M. Jablczynska, S. Jachmich, A.S. Jacobsen, P. Jacquet, A. Jansen van Vuuren, A. Jardin, H. Järleblad, A. Järvinen, F. Jaulmes, T. Jensen, I. Jepu, S. Jessica, T. Johnson, A. Juven, J. Kalis, J. Karhunen, R. Karimov, A.N. Karpushov, S. Kasilov, Y. Kazakov, P.V. Kazantzidis, W. Kernbichler, HT. Kim, D.B. King, V.G. Kiptily, A. Kirjasuo, K.K. Kirov, A. Kirschner, A. Kit, T. Kiviniemi, F. Kjær, E. Klinkby, A. Knieps, U. Knoche, M. Kochan, F. Köchl, G. Kocsis, J.T.W. Koenders, L. Kogan, Y. Kolesnichenko, Y. Kominis, M. Komm, M. Kong, B. Kool, S.B. Korsholm, D. Kos, M. Koubiti, J. Kovacic, Y. Kovtun, E. Kowalska Strzeciwilk, K. Koziol, M. Kozulia, A. Krämer Flecken, A. Kreter, K. Krieger, U. Kruezi, O. Krutkin, O. Kudlacek, U. Kumar, H. Kumpulainen, M.H. Kushoro, R. Kwiatkowski, M. La Matina, M. Lacquaniti, L. Laguardia, P. Lainer, P. Lang, M. Larsen, E. Laszynska, K.D. Lawson, A. Lazaros, E. Lazzaro, M.Y.K. Lee, S. Leerink, M. Lehnen, M. Lennholm, E. Lerche, Y. Liang, A. Lier, J. Likonen, O. Linder, B. Lipschultz, A. Listopad, X. Litaudon, E. Litherland Smith, D. Liuzza, T. Loarer, P.J. Lomas, J. Lombardo, N. Lonigro, R. Lorenzini, C. Lowry, T. Luda di Cortemiglia, A. Ludvig Osipov, T. Lunt, V. Lutsenko, E. Macusova, R. Mäenpää, P. Maget, C.F. Maggi, J. Mailloux, S. Makarov, K. Malinowski, P. Manas, A. Mancini, D. Mancini, P. Mantica, M. Mantsinen, J. Manyer, M. Maraschek, G. Marceca, G. Marcer, C. Marchetto, S. Marchioni, A. Mariani, M. Marin, M. Markl, T. Markovic, D. Marocco, S. Marsden, L. Martellucci, P. Martin, C. Martin, F. Martinelli, L. Martinelli, J.R. Martin Solis, R. Martone, M. Maslov, R. Masocco, M. Mattei, G.F. Matthews, D. Matveev, E. Matveeva, M.L. Mayoral, D. Mazon, S. Mazzi, C. Mazzotta, G. McArdle, R. McDermott, K. McKay, A.G. Meigs, C. Meineri, A. Mele, V. Menkovski, S. Menmuir, A. Merle, H. Meyer, K. Mikszuta Michalik, D. Milanesio, F. Militello, A. Milocco, I.G. Miron, J. Mitchell, R. Mitteau, V. Mitterauer, J. Mlynar, V. Moiseenko, P. Molna, F. Mombelli, C. Monti, A. Montisci, J. Morales, P. Moreau, J.M. Moret, A. Moro, D. Moulton, P. Mulholland, M. Muraglia, A. Murari, A. Muraro, P. Muscente, D. Mykytchuk, F. Nabais, Y. Nakeva, F. Napoli, E. Nardon, M.F. Nave, R.D. Nem, A. Nielsen, S.K. Nielsen, M. Nocente, R. Nouailletas, S. Nowak, H. Nyström, R. Ochoukov, N. Offeddu, S. Olasz, C. Olde, F. Oliva, D. Oliveira, H.J.C. Oliver, P. Ollus, J. Ongena, F.P. Orsitto, N. Osborne, R. Otin, P. Oyola Dominguez, D.I. Palade, S. Palomba, O. Pan, N. Panadero, E. Panontin, A. Papadopoulos, P. Papagiannis, G. Papp, V.V. Parail, C. Pardanaud, J. Parisi, A. Parrott, K. Paschalidis, M. Passoni, F. Pastore, A. Patel, B. Patel, A. Pau, G. Pautasso, R. Pavlichenko, E. Pawelec, B. Pegourie, G. Pelka, E. Peluso, A. Perek, E. Perelli Cippo, C. Perez Von Thun, P. Petersson, G. Petravich, Y. Peysson, V. Piergotti, L. Pigatto, C. Piron, L. Piron, A. Pironti, F. Pisano, U. Plank, B. Ploeckl, V. Plyusnin, A. Podolnik, Y. Poels, G. Pokol, J. Poley, G. Por, M. Poradzinski, F. Porcelli, L. Porte, C. Possieri, A. Poulsen, I. Predebon, G. Pucella, M. Pueschel, P. Puglia, O. Putignano, T. Pütterich, V. Quadri, A. Quercia, M. Rabinski, L. Radovanovic, R. Ragona, H. Raj, M. Rasinski, J. Rasmussen, G. Ratta, S. Ratynskaia, R. Rayaprolu, M. Rebai, A. Redl, D. Rees, D. Refy, M. Reich, H. Reimerdes, B.C.G. Reman, O. Renders, C. Reux, D. Ricci, M. Richou, S. Rienacker, D. Rigamonti, F. Rigollet, F.G. Rimini, D. Ripamonti, N. Rispoli, N. Rivals, J.F. Rivero Rodriguez, C. Roach, G. Rocchi, S. Rode, P. Rodrigues, J. Romazanov, C.F. Romero Madrid, J. Rosato, R. Rossi, G. Rubino, J. Rueda Rueda, J. Ruiz Ruiz, P. Ryan, D. Ryan, S. Saarelma, R. Sabot, M. Salewski, A. Salmi, L. Sanchis, A. Sand, J. Santos, K. Särkimäki, M. Sassano, O. Sauter, G. Schettini, S. Schmuck, P. Schneider, N. Schoonheere, R. Schramm, R. Schrittwieser, C. Schuster, N. Schwarz, F. Sciortino, M. Scotto D’Abusco, S. Scully, A. Selce, L. Senni, M. Senstius, G. Sergienko, S.E. Sharapov, R. Sharma, A. Shaw, U. Sheikh, G. Sias, B. Sieglin, S.A. Silburn, C. Silva, A. Silva, D. Silvagni, B. Simmendefeldt Schmidt, L. Simons, J. Simpson, L. Singh, S. Sipilä, Y. Siusko, S. Smith, A. Snicker, E.R. Solano, V. Solokha, M. Sos, C. Sozzi, F. Spineanu, G. Spizzo, M. Spolaore, L. Spolladore, C. Srinivasan, A. Stagni, Z. Stancar, G. Stankunas, J. Stober, P. Strand, C.I. Stuart, F. Subba, G.Y. Sun, H.J. Sun, W. Suttrop, J. Svoboda, T. Szepesi, G. Szepesi, B. Tal, T. Tala, P. Tamain, G. Tardini, M. Tardocchi, D. Taylor, G. Telesca, A. Tenaglia, A. Terra, D. Terranova, D. Testa, C. Theiler, E. Tholerus, B. Thomas, E. Thoren, A. Thornton, A. Thrysoe, Q. TICHIT, W. Tierens, A. Titarenko, P. Tolias, E. Tomasina, M. Tomes, E. Tonello, A. Tookey, M. Toscano Jiménez, C. Tsironis, C. Tsui, A. Tykhyy, M. Ugoletti, M. Usoltseva, D.F. Valcarcel, A. Valentini, M. Valisa, M. Vallar, M. Valovic, SI. Valvis, M. van Berkel, D. Van Eester, S. Van Mulders, M. van Rossem, R. Vann, B. Vanovac, J. Varela Rodriguez, J. Varje, S. Vartanian, M. Vecsei, L. Velarde Gallardo, M. Veranda, T. Verdier, G. Verdoolaege, K. Verhaegh, L. Vermare, G. Verona Rinati, J. Vicente, E. Viezzer, L. Vignitchouk, F. Villone, B. Vincent, P. Vincenzi, M.O. Vlad, G. Vogel, I. Voitsekhovitch, I. Voldiner, P. Vondracek, N.M.T. VU, T. Vuoriheimo, C. Wade, E. Wang, T. Wauters, M. Weiland, H. Weisen, N. Wendler, D. Weston, A. Widdowson, S. Wiesen, M. Wiesenberger, T. Wijkamp, M. Willensdorfer, T. Wilson, A. Wojenski, C. Wuethrich, I. Wyss, L. Xiang, S. Xu, D. Yadykin, Y. Yakovenko, H. Yang, V. Yanovskiy, R. Yi, B. Zaar, G. Zadvitskiy, L. Zakharov, P. Zanca, D. Zarzoso, Y. Zayachuk, J. Zebrowski, M. Zerbini, P. Zestanakis, C. F. B. Zimmermann, M. Zlobinski, A. Zohar, V.K. Zotta, X. Zou, M. Zuin, M. Zurita, and I. Zychor
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JET ,ASDEX Upgrade ,MAST-U ,TCV ,WEST ,Tokamak Exploitation Task Force ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Within the 9th European Framework programme, since 2021 EUROfusion is operating five tokamaks under the auspices of a single Task Force called ‘Tokamak Exploitation’. The goal is to benefit from the complementary capabilities of each machine in a coordinated way and help in developing a scientific output scalable to future largre machines. The programme of this Task Force ensures that ASDEX Upgrade, MAST-U, TCV, WEST and JET (since 2022) work together to achieve the objectives of Missions 1 and 2 of the EUROfusion Roadmap: i) demonstrate plasma scenarios that increase the success margin of ITER and satisfy the requirements of DEMO and, ii) demonstrate an integrated approach that can handle the large power leaving ITER and DEMO plasmas. The Tokamak Exploitation task force has therefore organized experiments on these two missions with the goal to strengthen the physics and operational basis for the ITER baseline scenario and for exploiting the recent plasma exhaust enhancements in all four devices (PEX: Plasma EXhaust) for exploring the solution for handling heat and particle exhaust in ITER and develop the conceptual solutions for DEMO. The ITER Baseline scenario has been developed in a similar way in ASDEX Upgrade, TCV and JET. Key risks for ITER such as disruptions and run-aways have been also investigated in TCV, ASDEX Upgrade and JET. Experiments have explored successfully different divertor configurations (standard, super-X, snowflakes) in MAST-U and TCV and studied tungsten melting in WEST and ASDEX Upgrade. The input from the smaller devices to JET has also been proven successful to set-up novel control schemes on disruption avoidance and detachment.
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- 2024
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116. Overview of physics results from MAST upgrade towards core-pedestal-exhaust integration
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J.R. Harrison, A. Aboutaleb, S. Ahmed, M. Aljunid, S.Y. Allan, H. Anand, Y. Andrew, L.C. Appel, A. Ash, J. Ashton, O. Bachmann, M. Barnes, B. Barrett, D. Baver, D. Beckett, J. Bennett, J. Berkery, M. Bernert, W. Boeglin, C. Bowman, J. Bradley, D. Brida, P.K. Browning, D. Brunetti, P. Bryant, J. Bryant, J. Buchanan, N. Bulmer, A. Carruthers, M. Cecconello, Z.P. Chen, J. Clark, C. Cowley, M. Coy, N. Crocker, G. Cunningham, I. Cziegler, T. Da Assuncao, Y. Damizia, P. Davies, I.E. Day, G.L. Derks, S. Dixon, R. Doyle, M. Dreval, M. Dunne, B.P. Duval, T. Eagles, J. Edmond, H. El-Haroun, S.D. Elmore, Y. Enters, M. Faitsch, F. Federici, N. Fedorczak, F. Felici, A.R. Field, M. Fitzgerald, I. Fitzgerald, R. Fitzpatrick, L. Frassinetti, W. Fuller, D. Gahle, J. Galdon-Quiroga, L. Garzotti, S. Gee, T. Gheorghiu, S. Gibson, K.J. Gibson, C. Giroud, D. Greenhouse, V.H. Hall-Chen, C.J. Ham, R. Harrison, S.S. Henderson, C. Hickling, B. Hnat, L. Howlett, J. Hughes, R. Hussain, K. Imada, P. Jacquet, P. Jepson, B. Kandan, I. Katramados, Y.O. Kazakov, D. King, R. King, A. Kirk, M. Knolker, M. Kochan, L. Kogan, B. Kool, M. Kotschenreuther, M. Lees, A.W. Leonard, G. Liddiard, B. Lipschultz, Y.Q. Liu, B.A. Lomanowski, N. Lonigro, J. Lore, J. Lovell, S. Mahajan, F. Maiden, C. Man-Friel, F. Mansfield, S. Marsden, R. Martin, S. Mazzi, R. McAdams, G. McArdle, K.G. McClements, J. McClenaghan, D. McConville, K. McKay, C. McKnight, P. McKnight, A. McLean, B.F. McMillan, A. McShee, J. Measures, N. Mehay, C.A. Michael, F. Militello, D. Morbey, S. Mordijck, D. Moulton, O. Myatra, A.O. Nelson, M. Nicassio, M.G. O’Mullane, H.J.C. Oliver, P. Ollus, T. Osborne, N. Osborne, E. Parr, B. Parry, B.S. Patel, D. Payne, C. Paz-Soldan, A. Phelps, L. Piron, C. Piron, G. Prechel, M. Price, B. Pritchard, R. Proudfoot, H. Reimerdes, T. Rhodes, P. Richardson, J. Riquezes, J.F. Rivero-Rodriguez, C.M. Roach, M. Robson, K. Ronald, E. Rose, P. Ryan, D. Ryan, S. Saarelma, S. Sabbagh, R. Sarwar, P. Saunders, O. Sauter, R. Scannell, T. Schuett, R. Seath, R. Sharma, P. Shi, B. Sieglin, M. Simmonds, J. Smith, A. Smith, V. A. Soukhanovskii, D. Speirs, G. Staebler, R. Stephen, P. Stevenson, J. Stobbs, M. Stott, C. Stroud, C. Tame, C. Theiler, N. Thomas-Davies, A.J. Thornton, M. Tobin, M. Vallar, R.G.L. Vann, L. Velarde, K. Verhaegh, E. Viezzer, C. Vincent, G. Voss, M. Warr, W. Wehner, S. Wiesen, T.A. Wijkamp, D. Wilkins, T. Williams, T. Wilson, H.R. Wilson, H. Wong, M. Wood, and V. Zamkovska
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MAST upgrade ,exhaust ,integrated scenarios ,alternative divertors ,pedestal ,fast ions ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Recent results from MAST Upgrade are presented, emphasising understanding the capabilities of this new device and deepening understanding of key physics issues for the operation of ITER and the design of future fusion power plants. The impact of MHD instabilities on fast ion confinement have been studied, including the first observation of fast ion losses correlated with Compressional and Global Alfvén Eigenmodes. High-performance plasma scenarios have been developed by tailoring the early plasma current ramp phase to avoid internal reconnection events, resulting in a more monotonic q profile with low central shear. The impact of m / n = 3/2, 2/1 and 1/1 modes on thermal plasma confinement and rotation profiles has been quantified, and scenarios optimised to avoid them have transiently reached values of normalised beta approaching 4.2. In pedestal and ELM physics, a maximum pedestal top temperature of ∼350 eV has been achieved, exceeding the value achieved on MAST at similar heating power. Mitigation of type-I ELMs with n = 1 RMPs has been observed. Studies of plasma exhaust have concentrated on comparing conventional and Super-X divertor configurations, while X-point target, X-divertor and snowflake configurations have been developed and studied in parallel. In L-mode discharges, the separatrix density required to detach the outer divertors is approximately a factor 2 lower in the Super-X than the conventional configuration, in agreement with simulations. Detailed analysis of spectroscopy data from studies of the Super-X configuration reveal the importance of including plasma-molecule interactions and D _2 Fulcher band emission to properly quantify the rates of ionisation, plasma-molecule interactions and volumetric recombination processes governing divertor detachment. In H-mode with conventional and Super-X configurations, the outer divertors are attached in the former and detached in the latter with no impact on core or pedestal confinement.
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- 2024
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117. Syncephalastrum massiliense sp. nov. and Syncephalastrum timoneanum sp. nov. Isolated from Clinical Samples
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Jihane Kabtani, Fatima Boulanouar, Papa Mouhamadou Gaye, Muriel Militello, and Stéphane Ranque
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mucormycosis ,Mucorales ,Syncephalastrum ,genotype ,phenotype ,one new taxon ,Biology (General) ,QH301-705.5 - Abstract
Mucormycosis is known to be a rare opportunistic infection caused by fungal organisms belonging to the Mucorales order, which includes the Syncephalastrum species. These moulds are rarely involved in clinical diseases and are generally seen as contaminants in clinical laboratories. However, in recent years, case reports of human infections due to Syncephalastrum have increased, especially in immunocompromised hosts. In this study, we described two new Syncephalastrum species, which were isolated from human nails and sputum samples from two different patients. We used several methods for genomic and phenotypic characterisation. The phenotypic analysis relied on the morphological features, analysed both by optical and scanning electron microscopy. We used matrix-assisted laser desorption–ionization time-of-flight mass spectrometry, energy-dispersive X-ray spectroscopy, and BiologTM technology to characterise the proteomic, chemical mapping, and carbon source assimilation profiles, respectively. The genomic analysis relied on a multilocus DNA sequence analysis of the rRNA internal transcribed spacers and D1/D2 large subunit domains, fragments of the translation elongation factor-1 alpha, and the β-tubulin genes. The two novel species in the genus Syncephalastrum, namely S. massiliense PMMF0073 and S. timoneanum PMMF0107, presented a similar morphology: irregular branched and aseptate hyphae with ribbon-like aspects and terminal vesicles at the apices all surrounded by cylindrical merosporangia. However, each species displayed distinct phenotypic and genotypic features. For example, S. timoneanum PMMF0107 was able to assimilate more carbon sources than S. massiliense PMMF0073, such as adonitol, α-methyl-D-glucoside, trehalose, turanose, succinic acid mono-methyl ester, and alaninamide. The polyphasic approach, combining the results of complementary phenotypic and genomic assays, was instrumental for describing and characterising these two new Syncephalastrum species.
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- 2024
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118. Mycobacterium chimaera Infections in a Unit of Cardio Surgery: Study at a General Hospital in Padua, Italy
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Silvia Cocchio, Michele Nicoletti, Fabio Zanella, Dania Gaburro, Roberto Bianco, Gino Gerosa, Cristina Contessa, Margherita Boschetto, Paola Stano, Valentina Militello, Claudia Cozzolino, Tiziano Martello, and Vincenzo Baldo
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Mycobacterium chimaera ,cardio surgery ,biosurveillance ,HCUs ,sustainable disinfection ,Biology (General) ,QH301-705.5 - Abstract
Mycobacterium chimaera is a slow-growing non-tuberculous mycobacterium already known for being able to colonize cardio surgery heater–cooler units (HCUs). This study aims to describe the real magnitude of the phenomenon, providing a methodological protocol and the results of a longitudinal survey. In the period 1 January 2017–23 May 2022, over 1191 samples were collected on 35 HCUs of two different manufacturers. Among them, we identified 118 (10.3%) positive results for M. chimaera. We propose our 4-year biosurveillance experience as a practical model to minimize microbiological patients’ risk, suggesting the need for new procedures and interventions for a safer and more ecological cardio surgery.
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- 2023
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119. Adiabatic Manipulation of a System Interacting with a Spin Bath
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Benedetto Militello and Anna Napoli
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STIRAP ,spin bath ,quantum Zeno effect ,Mathematics ,QA1-939 - Abstract
The Stimulated Raman Adiabatic Passage, a very efficient technique for manipulating a quantum system based on the adiabatic theorem, is analyzed in the case where the manipulated physical system is interacting with a spin bath. The exploitation of the rotating wave approximation allows for the identification of a constant of motion, which simplifies both the analytical and the numerical treatment, which allows for evaluating the total unitary evolution of the system and bath. The efficiency of the population transfer process is investigated in several regimes, including the weak and strong coupling with the environment and the off-resonance. The formation of appropriate Zeno subspaces explains the lowering of the efficiency in the strong damping regime.
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- 2023
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120. Stability of scrape-off layer plasma: a modified Rayleigh-Benard problem
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Wilczynski, Fryderyk, Hughes, David W., Van Loo, Sven, Arter, Wayne, and Militello, Fulvio
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Physics - Plasma Physics - Abstract
We present a linear stability analysis of a two-dimensional fluid model used to study the plasma dynamics in the scrape-off layer of tokamaks. The model equations are based on the Braginskii fluid equations under the assumptions of drift ordering and an electrostatic plasma. The model also employs the common slab geometry approximation, whereby the magnetic field is assumed constant and straight, with the effects of curvature reintroduced as effective gravitational terms. We demonstrate that the governing plasma equations for the scrape-off layer can be viewed as describing a thermal convection problem with additional effects. The new features include a non-uniform basic state gradient, linear damping terms, and additional advective terms. We characterise the conditions at the onset of instability, and perform an extensive parameter scan to describe how the stability threshold varies as a function of plasma parameters.
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- 2018
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121. Fluctuation characteristics of the TCV snowflake divertor measured with high speed visible imaging
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Walkden, N. R., Labit, B., Reimerdes, H., Harrison, J., Farley, T., Innocente, P., Militello, F., Team, the TCV, and Team, the MST1
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Physics - Plasma Physics - Abstract
Tangentially viewing fast camera footage of the low-field side snowflake minus divertor in TCV is analysed across a four point scan in which the proximity of the two X-points is varied systematically. The motion of structures observed in the post- processed movie shows two distinct regions of the camera frame exhibiting differing patterns. One type of motion in the outer scrape-off layer remains present throughout the scan whilst the other, apparent in the inner scrape-off layer between the two nulls, becomes increasingly significant as the X-points contract towards one another. The spatial structure of the fluctuations in both regions is shown to conform to the equilibrium magnetic field. When the X-point gap is wide the fluctuations measured in the region between the X-points show a similar structure to the fluctuations observed above the null region, remaining coherent for multiple toroidal turns of the magnetic field and indicating a physical connectivity of the fluctuations between the upstream and downstream regions. When the X-point gap is small the fluctuations in the inner scrape-off layer between the nulls are decorrelated from fluctuations upstream, indicating local production of filamentary structures. The motion of filaments in the inter-null region differs, with filaments showing a dominantly poloidal motion along magnetic flux surfaces when the X-point gap is large, compared to a dominantly radial motion across flux-surfaces when the gap is small. This demonstrates an enhancement to cross-field tranport between the nulls of the TCV low-field-side snowflake minus when the gap between the nulls is small., Comment: Accepted for publication in Plasma Physics and Controlled Fusion
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- 2018
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122. Steepest Entropy Ascent for Two-State Systems with Slowly Varying Hamiltonians
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Militello, Benedetto
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Quantum Physics - Abstract
The Steepest Entropy Ascent approach is considered and applied to few-state systems. When the Hamiltonian of the system is time dependent, the principle of maximum entropy production can still be exploited; arguments to support this fact are given. In the limit of slowly varying Hamiltonians which allows for the adiabatic approximation for the unitary part of the dynamics, the system exhibits significant robustness to the thermalization process. Specific examples such as a spin in a rotating field and a generic two-state system undergoing an avoided crossing are considered.
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- 2018
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123. Simple scheme for extracting work with a single bath
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Piccione, Nicolò, Militello, Benedetto, Napoli, Anna, and Bellomo, Bruno
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Quantum Physics - Abstract
We propose a simple protocol exploiting the thermalization of a $\textit{storage}$ bipartite system $S$ to extract work from a $\textit{resource}$ system $R$. The protocol is based on a recent work definition involving only a single bath. A general description of the protocol is provided without specifying the characteristics of $S$. We quantify both the extracted work and the ideal efficiency of the process also giving maximum bounds for them. Then, we apply the protocol to two cases: two interacting qubits and the Rabi model. In both cases, for very strong couplings, an extraction of work comparable with the bare energies of the subsystems of $S$ is obtained and its peak is reached for finite values of the bath temperature, $T$. We finally show, in the Rabi model at $T=0$, how to transfer the work stored in $S$ to an external device, permitting thus a cyclic implementation of the whole work-extraction protocol. Our proposal makes use of simple operations not needing fine control., Comment: 13 pages, 9 figures. Updated version close to the published one
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- 2018
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124. Influence of plasma background on 3D scrape-off layer filaments
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Schwörer, David, Walkden, Nicholas R, Leggate, Huw, Dudson, Ben D, Militello, Fulvio, Downes, Turlough, and Turner, Miles M
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Physics - Plasma Physics - Abstract
This paper presents the effect of self-consistent plasma backgrounds including plasma-neutral interactions, on the dynamics of filament propagation. The principle focus is on the influence of the neutrals on the filament through both direct interactions and through their influence on the plasma background. Both direct and indirect interactions influence the motion of filaments. A monotonic increase of filament peak velocity with upstream electron temperature is observed, while a decrease with increasing electron density is observed. If ordered by the target temperature, the density dependence disappears and the filament velocity is only a function of the target temperature. Smaller filaments keep a density dependence, as a result of the density dependence of the plasma viscosity. The critical size $\delta^*$, where filaments are fastest, is shifted to larger sizes for higher densities, due to the plasma viscosity. If the density dependence of the plasma viscosity is removed, $\delta^*$ has no temperature dependence, but rather a density dependence.
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- 2018
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125. Solution to a collisionless shallow-angle magnetic presheath with kinetic ions
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Geraldini, Alessandro, Parra, Felix I., and Militello, Fulvio
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Physics - Plasma Physics - Abstract
Using a kinetic model for the ions and adiabatic electrons, we solve a steady state, electron-repelling magnetic presheath in which a uniform magnetic field makes a small angle $\alpha \ll 1$ (in radians) with the wall. The presheath characteristic thickness is the typical ion gyroradius $\rho_{\text{i}}$. The Debye length $\lambda_{\text{D}}$ and the collisional mean free path of an ion $\lambda_{\text{mfp}}$ satisfy the ordering $\lambda_{\text{D}} \ll \rho_{\text{i}} \ll \alpha \lambda_{\text{mfp}}$, so a quasineutral and collisionless model is used. We assume that the electrostatic potential is a function only of distance from the wall, and it varies over the scale $\rho_{\text{i}}$. Using the expansion in $\alpha \ll 1$, we derive an analytical expression for the ion density that only depends on the ion distribution function at the entrance of the magnetic presheath and the electrostatic potential profile. Importantly, we have added the crucial contribution of the orbits in the region near the wall. By imposing the quasineutrality equation, we derive a condition that the ion distribution function must satisfy at the magnetic presheath entrance --- the kinetic equivalent of the Chodura condition. Using an ion distribution function at the entrance of the magnetic presheath that satisfies the kinetic Chodura condition, we find numerical solutions for the self-consistent electrostatic potential, ion density and flow across the magnetic presheath for several values of $\alpha$. Our numerical results also include the distribution of ion velocities at the Debye sheath entrance. We find that at small values of $\alpha$ there are substantially fewer ions travelling with a large normal component of the velocity into the wall., Comment: 69 pages, 20 figures
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- 2018
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126. Competition of Direct and Indirect Sources of Thermal Entanglement in a spin star network
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Militello, Benedetto and Napoli, Anna
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Quantum Physics - Abstract
A spin star system consisting of three peripheral two-state systems and a central one is considered, with the peripheral spins assumed to interact with each other, as well as with the central one. It is shown that such two couplings, each one being a thermal entanglement source, can significantly compete in the formation of quantum correlations in the thermal state, to the point that they can destroy any thermal entanglement of the peripheral spins., Comment: 10 pages, 6 figures
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- 2017
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127. Nested Coaching Links Learning from Coach to Leader to Teacher
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Tredway, Lynda, Simon, Ken, and Militello, Matthew
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Project I4 is a federally funded SEED (Supporting Effective Educator Development) grant, a partnership between East Carolina University and the Institute for Educational Leadership. It is a cohort-based, yearlong professional learning experience aimed at reimagining instructional leadership through an equity lens. Specifically, school leader participants build capacity to document evidence-based, equitable academic discourse during classroom observations. To support this, they implemented a nested coaching structure, which creates a vital through line from coaches to school leaders to teachers to impact student outcomes. The model supports school leaders as instructional leaders to work more effectively with teachers in the context of their own schools with a focus on improving teachers' equitable classroom practices. Together, they cultivate stronger relational trust and identify opportunities for more equitable practices. Two interdependent principles guide their work: (1) nested coaching networks are essential; and (2) an equity focus is fundamental. Reform that sticks comes from the inside. The leadership actions that they cultivate through Project I4 are like the superglue of professional development: relational trust, nested coaching structures, evidence-based tools, and effective conversations. If school leaders work with teachers in their schools to address local concerns and engage in community learning exchange processes, they can build stronger internal capacity for change.
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- 2021
128. Making Classroom Observations Matter
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Tredway, Lynda, Militello, Matt, and Simon, Ken
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Through Project I4 (which aims to lift academic discourse in STEM classes), principals and other school leaders who observe faculty use tools to identify, through evidence and clear criteria, what teachers are doing well and less well. The project's tools, including a post-observation Effective Conversation Guide, address aspects of equity (such as whether all students get a chance to speak) and rigor in lessons observed by leaders.
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- 2021
129. Medication decision-making for patients with renal insufficiency in inpatient and outpatient care at a US Veterans Affairs Medical Centre: a qualitative, cognitive task analysis.
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Elkhadragy, Nervana, Ifeachor, Amanda P, Diiulio, Julie B, Arthur, Karen J, Weiner, Michael, Militello, Laura G, Glassman, Peter A, Zillich, Alan J, and Russ, Alissa L
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Humans ,Medication Errors ,Cognition ,Decision Support Techniques ,Qualitative Research ,Adult ,Middle Aged ,Inpatients ,Outpatients ,Hospitals ,Veterans ,United States ,Female ,Male ,Renal Insufficiency ,Interviews as Topic ,Clinical Decision-Making ,health and safety ,medical education and training ,nephrology ,qualitative research ,Clinical Sciences ,Public Health and Health Services ,Other Medical and Health Sciences - Abstract
BackgroundMany studies identify factors that contribute to renal prescribing errors, but few examine how healthcare professionals (HCPs) detect and recover from an error or potential patient safety concern. Knowledge of this information could inform advanced error detection systems and decision support tools that help prevent prescribing errors.ObjectiveTo examine the cognitive strategies that HCPs used to recognise and manage medication-related problems for patients with renal insufficiency.DesignHCPs submitted documentation about medication-related incidents. We then conducted cognitive task analysis interviews. Qualitative data were analysed inductively.SettingInpatient and outpatient facilities at a major US Veterans Affairs Medical Centre.ParticipantsPhysicians, nurses and pharmacists who took action to prevent or resolve a renal-drug problem in patients with renal insufficiency.OutcomesEmergent themes from interviews, as related to recognition of renal-drug problems and decision-making processes.ResultsWe interviewed 20 HCPs. Results yielded a descriptive model of the decision-making process, comprised of three main stages: detect, gather information and act. These stages often followed a cyclical path due largely to the gradual decline of patients' renal function. Most HCPs relied on being vigilant to detect patients' renal-drug problems rather than relying on systems to detect unanticipated cues. At each stage, HCPs relied on different cognitive cues depending on medication type: for renally eliminated medications, HCPs focused on gathering renal dosing guidelines, while for nephrotoxic medications, HCPs investigated the need for particular medication therapy, and if warranted, safer alternatives.ConclusionsOur model is useful for trainees so they can gain familiarity with managing renal-drug problems. Based on findings, improvements are warranted for three aspects of healthcare systems: (1) supporting the cyclical nature of renal-drug problem management via longitudinal tracking mechanisms, (2) providing tools to alleviate HCPs' heavy reliance on vigilance and (3) supporting HCPs' different decision-making needs for renally eliminated versus nephrotoxic medications.
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- 2019
130. From the Landscape of Contrasts to the Landscape of Invisible Cities: A Strategic Landscape Design for the Revitalization of the Ancient Greek Colony of Megara Hyblaea in Sicily
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Simona Calvagna, Pietro Maria Militello, Fabio Agatino Reale, Gianluca Rodonò, and Andrea Tornabene
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Architecture ,NA1-9428 - Abstract
The present research aims at revitalising the archaeological park of Megara Hyblaea through innovative strategies developed within the PON project “An early warning system for cultural heritage/e-WAS”. In this project Sicilian research institutions, universities and companies pursue the common goal of developing new technologies for the protection, enhancement and strategic management of the historical and cultural heritage. The ancient Greek colony of Megara Hyblaea is immersed in an industrial landscape that stretches along the coast of eastern Sicily from Augusta to Syracuse. The sense of the original place has been obliterated by an indiscriminate occupation of the land by industries which have left, here and there, an archipelago of “patrimonial wrecks”, which are equally close to the smelly chimneys and the horizon of the sea. This landscape of contrasts, dominated by petrochemical industries, has over time hindered a cultural tourism appropriate to the representativeness and importance of the asset, despite the efforts made by the authorities responsible for its protection. The paper demonstrates the need for a holistic approach to the revitalisation project of the archaeological site: the strategic design, understood as the story of the overlapping of “invisible cities”, aims to reorganise and re-conquer places through a new narrative coherent with hidden values, going as far as the experimentation of innovative technologies for the creation of facilities for the enjoyment of the park.
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- 2022
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131. Study protocol for a type III hybrid effectiveness-implementation trial to evaluate scaling interoperable clinical decision support for patient-centered chronic pain management in primary care
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Ramzi G. Salloum, Lori Bilello, Jiang Bian, Julie Diiulio, Laura Gonzalez Paz, Matthew J. Gurka, Maria Gutierrez, Robert W. Hurley, Ross E. Jones, Francisco Martinez-Wittinghan, Laura Marcial, Ghania Masri, Cara McDonnell, Laura G. Militello, François Modave, Khoa Nguyen, Bryn Rhodes, Kendra Siler, David Willis, and Christopher A. Harle
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Medicine (General) ,R5-920 - Abstract
Abstract Background The US continues to face public health crises related to both chronic pain and opioid overdoses. Thirty percent of Americans suffer from chronic noncancer pain at an estimated yearly cost of over $600 billion. Most patients with chronic pain turn to primary care clinicians who must choose from myriad treatment options based on relative risks and benefits, patient history, available resources, symptoms, and goals. Recently, with attention to opioid-related risks, prescribing has declined. However, clinical experts have countered with concerns that some patients for whom opioid-related benefits outweigh risks may be inappropriately discontinued from opioids. Unfortunately, primary care clinicians lack usable tools to help them partner with their patients in choosing pain treatment options that best balance risks and benefits in the context of patient history, resources, symptoms, and goals. Thus, primary care clinicians and patients would benefit from patient-centered clinical decision support (CDS) for this shared decision-making process. Methods The objective of this 3-year project is to study the adaptation and implementation of an existing interoperable CDS tool for pain treatment shared decision making, with tailored implementation support, in new clinical settings in the OneFlorida Clinical Research Consortium. Our central hypothesis is that tailored implementation support will increase CDS adoption and shared decision making. We further hypothesize that increases in shared decision making will lead to improved patient outcomes, specifically pain and physical function. The CDS implementation will be guided by the Exploration, Preparation, Implementation, Sustainment (EPIS) framework. The evaluation will be organized by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. We will adapt and tailor PainManager, an open source interoperable CDS tool, for implementation in primary care clinics affiliated with the OneFlorida Clinical Research Consortium. We will evaluate the effect of tailored implementation support on PainManager’s adoption for pain treatment shared decision making. This evaluation will establish the feasibility and obtain preliminary data in preparation for a multi-site pragmatic trial targeting the effectiveness of PainManager and tailored implementation support on shared decision making and patient-reported pain and physical function. Discussion This research will generate evidence on strategies for implementing interoperable CDS in new clinical settings across different types of electronic health records (EHRs). The study will also inform tailored implementation strategies to be further tested in a subsequent hybrid effectiveness-implementation trial. Together, these efforts will lead to important new technology and evidence that patients, clinicians, and health systems can use to improve care for millions of Americans who suffer from pain and other chronic conditions. Trial registration ClinicalTrials.gov, NCT05256394 , Registered 25 February 2022.
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- 2022
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132. The physics of turbulence localised to the tokamak divertor volume
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Nicholas Walkden, Fabio Riva, James Harrison, Fulvio Militello, Thomas Farley, John Omotani, and Bruce Lipschultz
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Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Fusion generated within magnetically confined plasmas offers a promising route to clean baseload energy but the intense heat and particle flux generated in the process presents a major challenge for future power plant devices. Through a combination of experiment and computational analysis the authors develop a potential first-principals understanding of turbulent processes in the divertor of their device, where excess heat is handled, paving the way to predictive tokamak solutions for the future.
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- 2022
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133. Comparative study of the effects of increasing heat transfer area within compression and expansion chambers in combination with modified pistons in Stirling engines. A simulation approach based on CFD and a numerical thermodynamic model
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Regalado-Rodríguez, Nuria and Militello, Carmelo
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- 2022
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134. A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice
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Benraiss, Abdellatif, Mariani, John N., Tate, Ashley, Madsen, Pernille M., Clark, Kathleen M., Welle, Kevin A., Solly, Renee, Capellano, Laetitia, Bentley, Karen, Chandler-Militello, Devin, and Goldman, Steven A.
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- 2022
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135. Virtual Reality Classroom Simulations: How School Leaders Improve Instructional Leadership Capacity
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Militello, Matthew, Tredway, Lynda, Hodgkins, Lawrence, and Simon, Ken
- Abstract
Purpose: The purpose of this study was to explore the utility of a virtual reality (VR) classroom experience for improving the capacity of instructional leaders. Specifically, school leaders used VR to build their classroom observation and analysis skills to prepare to have more effective post-observation conversations with teachers. The authors provide insights from multiple data points that highlight the affordances of the virtual setting for improving classroom observation skills. Design/methodology/approach: Drawing on the application of simulations to practice classroom observations, the authors developed a VR experience in which participants tag observable elements of academic discourse using codes from two observation protocols. The protocols identify elements of equitable student access: how teachers call on students and how they design questions. Seventy-five school leaders used the VR platform to observe a classroom scenario and code evidence of equitable classroom access. The authors analyzed data from tagging in the virtual reality scenario and triangulated these data with survey data focused on observation practices from participants' schools. A reflection component is included on the platform to collect these qualitative data. Findings: The study results indicate that the virtual reality platform provides an innovative process for leadership professional development focused on building school leaders' capacity to identify elements of academic discourse during classroom observations. Participants reported that the opportunity to practice classroom observations in a risk-free environment was useful. However, for school leaders to fully transfer the data to using in conversations with teachers, they benefit from leadership coaching. Originality/value: This study ascertains the potential effectiveness of an advanced technology for enhancing instructional leadership by using evidence-based classrooms observations to drive improvements in teaching practice. Beyond the utility of the virtual reality tool, this study provides a proof of concept for the next generation of instructional leadership through teacher observations with augmented reality.
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- 2021
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136. Benefits and Challenges of Advanced Divertor Configurations in DEMO
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Kembleton, R., Siccinio, M., Maviglia, F., and Militello, F.
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- 2022
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137. 3D DCE-MRI Radiomic Analysis for Malignant Lesion Prediction in Breast Cancer Patients
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Militello, Carmelo, Rundo, Leonardo, Dimarco, Mariangela, Orlando, Alessia, Woitek, Ramona, D'Angelo, Ildebrando, Russo, Giorgio, and Bartolotta, Tommaso Vincenzo
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- 2022
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138. Exploring how caregivers for people living with dementia use strategies to overcome work system constraints
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Weiler, Dustin T., Lingg, Aloysius J., Wilkins, David M., Militello, Laura, and Werner, Nicole E.
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- 2022
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139. The Good, the Bad, and the Potential: Best Practices for Navigating Technology Use Among Pediatric Populations
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Militello, Lisa and Hutson, Elizabeth
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- 2022
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140. Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51
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Turdo, Alice, Gaggianesi, Miriam, Di Franco, Simone, Veschi, Veronica, D’Accardo, Caterina, Porcelli, Gaetana, Lo Iacono, Melania, Pillitteri, Irene, Verona, Francesco, Militello, Gabriella, Zippo, Alessio, Poli, Vittoria, Fagnocchi, Luca, Beyes, Sven, Stella, Stefania, Lattanzio, Rossano, Faldetta, Naida, Lentini, Vincenzo L., Porcasi, Rossana, Pistone, Giuseppe, Bongiorno, Maria Rita, Stassi, Giorgio, De Maria, Ruggero, and Todaro, Matilde
- Published
- 2022
- Full Text
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141. Study protocol for a type III hybrid effectiveness-implementation trial to evaluate scaling interoperable clinical decision support for patient-centered chronic pain management in primary care
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Salloum, Ramzi G., Bilello, Lori, Bian, Jiang, Diiulio, Julie, Paz, Laura Gonzalez, Gurka, Matthew J., Gutierrez, Maria, Hurley, Robert W., Jones, Ross E., Martinez-Wittinghan, Francisco, Marcial, Laura, Masri, Ghania, McDonnell, Cara, Militello, Laura G., Modave, François, Nguyen, Khoa, Rhodes, Bryn, Siler, Kendra, Willis, David, and Harle, Christopher A.
- Published
- 2022
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142. Preliminary results indicate that regular training induces high protection against oxidative stress in basketball players compared to soccer
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Luti, Simone, Militello, Rosamaria, Fiaschi, Tania, Magherini, Francesca, Gamberi, Tania, Parri, Matteo, Marzocchini, Riccardo, Pratesi, Simone, Soldaini, Riccardo, Modesti, Alessandra, and Modesti, Pietro A.
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- 2022
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143. The physics of turbulence localised to the tokamak divertor volume
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Walkden, Nicholas, Riva, Fabio, Harrison, James, Militello, Fulvio, Farley, Thomas, Omotani, John, and Lipschultz, Bruce
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- 2022
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144. Stem Cells and the Microenvironment: Reciprocity with Asymmetry in Regenerative Medicine
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Guglielmo, Militello and Marta, Bertolaso
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- 2022
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145. INTEGRATED 3D SURVEY FOR THE DOCUMENTATION AND VISUALIZATION OF A ROCK-CUT UNDERGROUND BUILT HERITAGE
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G. D’Agostino, M. Figuera, G. Russo, M. Galizia, and P. M. Militello
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
The research presented here is part of an on-going research focused on the 3D documentation of rock-cut Underground Built Heritage with a complex morphology and characterised by narrow spaces, the Hypogeum of Calaforno (province of Ragusa, Sicily). It is one of the most interesting prehistoric monuments in Sicily in terms of size and unique rock-cut architecture. Various digital techniques have been tested over the years on the site, to represent its spatiality, such as Laser Scanner and Structure from Motion. The proposed methodological approach for the knowledge and the documentation of this archaeological site is based on an interdisciplinary approach involving archaeological and engineering disciplines. This paper focuses on the use of expeditious techniques such as iMMS (indoor Mobile Mapping Systems) based on SLAM (Simultaneous Localization and Mapping) and on the comparison of different surveying equipment in order to verify data quality and accuracy, as well as the inherent advantages of using one technology over another in relation to the characteristics of the site. Through the global verification of TLS and SLAM model reliability, we maintain that such research can contribute to enriching the protocols surrounding the archaeological investigation of sites characterized by complex morphology, irregular surfaces, narrow spaces, specific chromatic features, scarce or total lack of lighting, and physical obstacles.
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- 2022
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146. Star network synchronization led by strong coupling-induced frequency squeezing
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Militello, Benedetto, Chruściński, Dariusz, and Napoli, Anna
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Quantum Physics - Abstract
We consider a star network consisting of N oscillators coupled to a central one which in turn is coupled to an infinite set of oscillators (reservoir), which makes it leaking. Two of the N + 1 normal modes are dissipating, while the remaining N - 1 lie in a frequency range which is more and more squeezed as the coupling strengths increase, which realizes synchronization of the single parts of the system.
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- 2017
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147. Speeding up antidynamical Casimir effect with nonstationary qutrits
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Dodonov, A V, Díaz-Guevara, J J, Napoli, A, and Militello, B
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Quantum Physics - Abstract
The antidynamical Casimir effect (ADCE) is a term coined to designate the coherent annihilation of excitations due to resonant external perturbation of system parameters, allowing for extraction of quantum work from nonvacuum states of some field. Originally proposed for a two-level atom (qubit) coupled to a single cavity mode in the context of nonstationary quantum Rabi model, it suffered from very low transition rate and correspondingly narrow resonance linewidth. In this paper we show analytically and numerically that the ADCE rate can be increased by at least one order of magnitude by replacing the qubit by an artificial three-level atom (qutrit) in a properly chosen configuration. For the cavity thermal state we demonstrate that the dynamics of the average photon number and atomic excitation is completely different from the qubit's case, while the behavior of the total number of excitations is qualitatively similar yet significantly faster., Comment: 9 pages, 4 figures
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- 2017
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148. Sensitivity of Measurement-Based Purification Processes to Inner Interactions
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Militello, B. and Napoli, A.
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Quantum Physics - Abstract
The sensitivity of a repeated measurement-based purification scheme to additional undesired couplings is analyzed, focusing on the very simple and archetypical system consisting of two two-level systems interacting with a repeatedly measured one. Several regimes are considered and in the strong coupling (i.e., when the coupling constant of the undesired interaction is very large) the occurrence of a quantum Zeno effect is proven to dramatically jeopardize the efficiency of the purification process., Comment: 12 pages, 6 figures
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- 2017
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149. Quiescence near the X-point of MAST measured by high speed visible imaging
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Walkden, N. R., Harrison, J., Silburn, S. A., Farley, T., Henderson, S. S., Kirk, A., Militello, F., and Team, the MAST
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Physics - Plasma Physics - Abstract
Using high speed imaging of the divertor volume, the region close to the X-point in MAST is shown to be quiescent. This is confirmed by three different analysis techniques and the quiescent X-point region (QXR) spans from the separatrix to the 1.02 flux surface. Local reductions to the atomic density and effects associated with the camera viewing geometry are ruled out as causes of the QXR, leaving quiescence in the local plasma conditions as being the most likely cause. The QXR is found to be ubiquitous across a significant operational space in MAST including L-mode and H-mode discharges across wide ranges of line averaged density, plasma current and NBI power. When mapped to the divertor target the QXR occupies approximately an e-folding length of the heat-flux profile, containing approximately 60% of the total heat flux to the target, and also shows a tendency towards higher frequency shorter lived fluctuations in the ion-saturation current. This is consistent with short- lived divertor localised filamentary structures observed further down the outer divertor leg in the camera images, and suggests a complex multi-region picture of filamentary transport in the divertor.
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- 2017
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150. Interpretation of scrape-off layer profile evolution and first-wall ion flux statistics on JET using a stochastic framework based on filamentary motion
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Walkden, N. R., Wynn, A., Militello, F., Lipschultz, B., Matthews, G., Guillemaut, C., Harrison, J., Moulton, D., and Contributors, JET
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Physics - Plasma Physics - Abstract
This paper presents the use of a novel modelling technique based around intermittent transport due to filament motion, to interpret experimental profile and fluctuation data in the scrape-off layer (SOL) of JET during the onset and evolution of a density profile shoulder. A baseline case is established, prior to shoulder formation, and the stochastic model is shown to be capable of simultaneously matching the time averaged profile measurement as well as the PDF shape and autocorrelation function from the ion-saturation current time series at the outer wall. Aspects of the stochastic model are then varied with the aim of producing a profile shoulder with statistical measurements consistent with experiment. This is achieved through a strong localised reduction in the density sink acting on the filaments within the model. The required reduction of the density sink occurs over a highly localised region with the timescale of the density sink increased by a factor of 25. This alone is found to be insufficient to model the expansion and flattening of the shoulder region as the density increases, which requires additional changes within the stochastic model. An example is found which includes both a reduction in the density sink and filament acceleration and provides a consistent match to the experimental data as the shoulder expands, though the uniqueness of this solution can not be guaranteed. Within the context of the stochastic model, this implies that the localised reduction in the density sink can trigger shoulder formation, but additional physics is required to explain the subsequent evolution of the profile.
- Published
- 2017
- Full Text
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