123 results on '"Migliori S."'
Search Results
102. Addressing the feasibility of inboard direct-line injection of high-speed pellets, for core fueling of DEMO
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Chr. Day, B. Pégourié, Fabio Moro, Bernhard Ploeckl, A. Colangeli, Rocco Mozzillo, T. E. Gebhart, Larry R. Baylor, F. Bombarda, Antonio Frattolillo, Fabio Cismondi, Silvio Migliori, F. Iannone, Peter Lang, G. D’Elia, S.K. Combs, F. Poggi, Salvatore Podda, Steven J. Meitner, Frattolillo, A., Baylor, L. R., Bombarda, Andrea, Cismondi, F., Colangeli, Raimondo, Combs, S. K., Day, C., D'Elia, G., Gebhart, T. E., Iannone, F., Lang, P. T., Meitner, S. J., Migliori, S., Moro, F., Mozzillo, R., Pegourie, B., Ploeckl, B., Podda, S., Poggi, F., Bombarda, F., and Colangeli, A.
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EU-DEMO tokamak ,010302 applied physics ,Materials science ,Tokamak ,Line-of-sight ,Straight guide tubes ,Mechanical Engineering ,Pellets ,Conical surface ,Mechanics ,Curvature ,7. Clean energy ,01 natural sciences ,High Field Side high-speed pellet injection ,010305 fluids & plasmas ,law.invention ,Nuclear Energy and Engineering ,Neutron flux ,law ,0103 physical sciences ,Electromagnetic shielding ,General Materials Science ,Neutron ,Civil and Structural Engineering - Abstract
Pellet injection represents, to date, the most promising option for core fuelling of the EU-DEMO tokamak. Simulations with the HPI2 pellet ablation/deposition code indicate, however, that sufficiently deep fuel deposition requires injection from the High Field Side (HFS) at velocities ≳1 km/s. Two complementary inboard injection schemes are being explored: one makes use of guide tubes with curvature radii ≥6 m in the attempt of preserving pellet integrity at speeds of ˜1 km/s, the other is investigating the feasibility of injecting high-speed (˜3 km/s) pellets along “direct line of sight” (DLS) trajectories, from either the HFS or a vertical port. Options using quasi-vertical DLS paths routed across the upper vertical port have been explored first, as they can be more easily integrated, Unfortunately, the radial position of the available vertical access (≳9 m from the machine axis) turns out to be unfavorable; further simulations with the HPI2 code predict indeed that vertical injection may be effective only if pellets trajectories are well inboard the magnetic axis. High-speed injection through oblique inboard “DLS” paths, not interfering with the Central Solenoid (CS), are instead predicted to yield good performance, provided that the injection location is ≲2.5 m from the equatorial mid-plane. The angular spread of high-speed free-flight pellets, recently measured using an existing facility, turns out to be enclosed within ˜ 0.7°. This scatter cone may require significant cut off volume of the Breeding Blanket (BB). Moreover, DLS in-vessel conical penetrations may increase the neutron flux outside of the bio-shield, and also result in a significant heat load in the cryogenic pellet source. These issues are being investigated, to identify suitable shielding strategies; preliminary results are reported. The suitability of straight guide tubes to reduce the scatter cone, and hence the corresponding open cross section on BB penetration and the neutron streaming, will be explored as a further step. © 2019 Elsevier B.V.
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- 2019
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103. Study of solid molecular deuterium D2 growth under gas pressure
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S. Giusepponi, F. Buonocore, M. Celino, M. Lupo Pasini, A. Frattolillo, S. Migliori, Giusepponi, S., Buonocore, F., Celino, M., Lupo Pasini, M., Frattolillo, A., and Migliori, S.
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Nuclear Energy and Engineering ,Molecular dynamics simulations ,Mechanical Engineering ,General Materials Science ,Pellet formation ,Deuterium ,Civil and Structural Engineering - Abstract
The injection of high-speed cryogenic pellets made of frozen hydrogen-isotopes, represents to date the most effective method to fuel magnetically confined thermonuclear fusion plasmas. Moreover, the injection of very large pellets composed of cryogenic solid of some suitable impurity (typically a noble-gas such as H2, Ne, or H2/Ne, D2/Ne mixtures), shattered in relatively small fragments just before entering the plasma, seems to be the most promising method to reduce the damage risks for the plasma-facing components in case of a plasma disruption. This technology, known as "Shattered Pellet Injection" (SPI), allows to spread out the plasma energy and mitigate possible damage to the in-vessel components, as well as to densify the plasma to suppress the formation of runaway electrons, and/or dissipate their energy. Several techniques to produce and launch cryogenic pellets have been investigated in the past decades. "Pipe gun" injectors are reliable and relatively simple devices are still commonly used today. They make use of single- or two-stage pneumatic light-gas guns to accelerate the pellet at high speeds. In these injectors, the cryogenic pellets are formed “in situ” (i.e., inside the launching barrel), by de-sublimating them directly from the gas phase, i.e., at temperatures and pressures below those of the triple point. The simplest case is pure deuterium pellets (T < 18.7 K, P < 171.3 hPa). The production of good quality solid deuterium, capable of withstanding the mechanical stress during the acceleration of the pellets, is a key issue. To this end the phase transition of deuterium from gas to solid (and vice versa) is modeled with extensive molecular-dynamics (MD) simulations. Moreover, the solid growth from the gas phase is simulated in an ample range of temperatures and pressures, to find the best compromise between growth velocity and mechanical properties of the resulting solid system.
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- 2022
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104. A Brand Scoring System for Cryptocurrencies Based on Social Media Data
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Giuseppe Santomauro, Fiorenzo Ambrosino, Daniela Alderuccio, Silvio Migliori, Andrea Fronzetti Colladon, Santomauro, G., Alderuccio, D., Ambrosino, F., Fronzetti Colladon, A., and Migliori, S.
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Cryptocurrency ,Computer science ,Financial trends ,Semantic brand scoring ,Social network crawling ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,Crawling ,computer.software_genre ,World Wide Web ,Data retrieval ,Virtual machine ,Digital currency ,Virtual Laboratory ,Social media ,Financial trend ,Web crawler ,computer - Abstract
In this work, we present an overview on the development and integration in ENEAGRID of some tools to evaluate brand importance of homogeneous financial instruments, such as cryptocurrencies. Our system is based on the analysis of textual data, such as tweets or online news. A collaborative environment called Web Crawling Virtual Laboratory allows data retrieval from the web. Below we describe this virtual lab and the ongoing activity aimed at adding a new feature, to allow news and social media crawling. We also provide some details about the integration in ENEAGRID of a new measure of brand importance and its Virtual Laboratory, namely the Semantic Brand Score. We aim to test the first version of this new virtual environment on Twitter data, to rank digital currencies.
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- 2020
105. Modelli 3D e dati GIS: una loro integrazione per lo studio e la valorizzazione dei beni culturali
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M. Canciani, M. Saccone, G. Spadafora, S. Migliori, M. Mongelli, M. Puccini, A. Quintiliani, A. Gallia, C. Masetti, Canciani, M., Saccone, M., Spadafora, G., Migliori, S., Mongelli, M., Puccini, M., Quintiliani, A., Gallia, A., and Masetti, C.
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- 2020
106. A Web Crawling Environment to Support Financial Strategies and Trend Correlation
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Matteo De Rosa, Agostino Funel, Giovanni Ponti, Dante Giammattei, Fiorenzo Ambrosino, Silvio Migliori, Guido Guarnieri, Antonio Colavincenzo, Giuseppe Santomauro, Giovanni Bracco, Ponti, G., Santomauro, G., Ambrosino, F., Bracco, G., Colavincenzo, A., De Rosa, M., Funel, A., Giammattei, D., Guarnieri, G., and Migliori, S.
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Finance ,Big data ,Machine learning ,Market trends ,Web crawling ,business.industry ,Computer science ,Crawling ,Market trend ,Virtual Laboratory ,business ,Web crawler ,Relevant information - Abstract
We provide an overview on the development and the integration in ENEAGRID of a web crawling tool to retrieve data from the Web, manage and display it, and extract relevant information. We collected all these instruments in a collaborative environment called Web Crawling Virtual Laboratory, offering a GUI to operate remotely. Finally, we describe an ongoing activity on semantic crawling and data analysis to discover trends and correlations in finance.
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- 2019
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107. Remote control of a high-speed pellet injector and data synchronization & sharing tools
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F. Bombarda, Steven J. Meitner, F. Iannone, Salvatore Podda, G. D’Elia, Antonio Frattolillo, S.K. Combs, Silvio Migliori, T. E. Gebhart, F. Poggi, Larry R. Baylor, Iannone, F., Frattolillo, A., Bombarda, F., D'Elia, G., Migliori, S., Podda, S., Poggi, F., Combs, S. K., Baylor, L. R., Gebhart, T. E., and Meitner, S. J.
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Cloud storage ,Computer science ,Tokamak ,computer.software_genre ,law.invention ,Data acquisition ,law ,General Materials Science ,Data synchronization ,File synchronization ,High-speed pellet injector ,Control & DAS ,Data handling ,Plasma fuelling ,Civil and Structural Engineering ,Mechanical Engineering ,DAS ,Control room ,Control & ,Metadata ,Data access ,Nuclear Energy and Engineering ,Operating system ,computer ,Remote control - Abstract
The four-barrel, two-stage gun Ignitor Pellet Injector (IPI) was developed in collaboration between ENEA and ORNL. The prototype injector is presently located at Oak Ridge (TN, USA), and is normally operated locally through a control and data acquisition system developed in LabVIEW. More recently, a remote-control system has been set up, based on RealVNC®, which allows to operate the IPI from a control room in Italy. Tools for data transfer and storage into ENEA ICT area have also been provided. A Staging, Storage and Sharing system, named E3S, developed using OwnCloud as architectural component, is used for file synchronization and sharing of the data acquired by the diagnostic systems. It provides a homogeneous platform able to store and share heterogeneous data produced by many data acquisition systems in large nuclear fusion experiments. This paper reports about the implementation of the IPI remote control, and presents the application of E3S to this specific case, allowing easy storage and sharing of experimental data onto a wide-area distributed file-system, as well as remote data access via web-services based on MDS+ tool, integrated with MySQL metadata. A performance analysis of the architectural components is also introduced.
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- 2019
108. Selectable flight tube design developments for iter fueling, ELM pacing, and impurity pellets
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S.K. Combs, M. S. Lyttle, T. Ha, Silvio Migliori, Kirby Logan, Larry R. Baylor, T. Bjorholm, Steven J. Meitner, C.R. Foust, Antonio Frattolillo, Migliori, S., and Frattolillo, A.
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ELM control ,Engineering ,flight tube selector ,ITER pellets ,business.industry ,Nuclear engineering ,digestive, oral, and skin physiology ,Plastics extrusion ,Pellets ,Solenoid ,Structural engineering ,Pneumatic valve ,Impurity ,Tube (fluid conveyance) ,business ,Edge-localized mode ,Punching - Abstract
ITER fueling and Edge Localized Mode (ELM) pacing pellets will be created by punching and chambering pellets with a solenoid operated cutter from an extrudate formed by a twin-screw extruder. The cut pellets are then accelerated down a flight tube by a fast pneumatic valve. The impurity pellets are formed in-situ with a pipe gun technique and accelerated down a flight tube with the same pneumatic valve design. © 2015 IEEE.
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- 2015
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109. Perspectives for the High Field Approach in Fusion Research and Advances within the Ignitor Program
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S. Mantovani, Bruno Coppi, Marco Tavani, Adele D'Amico, M. Sassi, A. DeVellis, P. Detragiache, Giovanna Cenacchi, Francesco Giammanco, P. Ferraris, Silvio Migliori, Alfredo Pironti, G. De Tommasi, S. Spillantini, G. Ramogida, G. Grasso, A. Airoldi, Fabio Villone, Guglielmo Rubinacci, A. Perona, L. Zucchi, A. Cardinali, Antonio Frattolillo, R. Napoli, A. Tumino, Giuseppe Ambrosino, F. Conti, L. Merriman, M. Lazzaretti, Raffaele Albanese, Samuele Pierattini, G. Belforte, Enrico Costa, E. Boggio-Sella, A. Sestero, G. Faelli, Coppi, B., Airoldi, A., Albanese, Raffaele, Ambrosino, Giuseppe, Belforte, G., Boggio Sella, E., Cardinali, A., Conti, F., Costa, E., D'Amico, A., Detragiache, P., DE TOMMASI, Gianmaria, Devellis, A., Faelli, G., Ferraris, P., Frattolillo, A., Giammanco, F., Grasso, D., Lazzaretti, M., Mantovani, S., Merriman, L., Migliori, S., Napoli, R., Perona, A., Pierattini, S., Pironti, Alfredo, Ramogida, A. G., Rubinacci, Guglielmo, Sassi, M., Sestero, A., Tavani, M., Tumino, A., Villone, F., and Zucchi, L.
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Nuclear and High Energy Physics ,Fusion ,Thermonuclear fusion ,Computer science ,Nuclear engineering ,fusion reactors ,Welding ,Superconducting magnet ,Plasma ,Condensed Matter Physics ,IGNITOR ,burning plasmas ,law.invention ,Ignition system ,Physics::Plasma Physics ,law ,Magnet ,ignition ,burning plasma - Abstract
The Ignitor Program maintains the objective of approaching D-T ignition conditions by incorporating systematical advances made with relevant high field magnet technology and with experiments on high density well confined plasmas in the present machine design. An additional objective is that of charting the development of the high field line of experiments that goes from the Alcator machine to the ignitor device. The rationale for this class of experiments, aimed at producing poloidal fields with the highest possible values (compatible with proven safety factors of known plasma instabilities) is given. On the basis of the favourable properties of high density plasmas produced systematically by this line of machines, the envisioned future for the line, based on novel high field superconducting magnets, includes the possibility of investigating more advanced fusion burn conditions than those of the D-T plasmas for which Ignitor is designed. Considering that a detailed machine design has been carried out (Coppi et al 2013 Nucl. Fusion 53 104013), the advances made in different areas of the physics and technology that are relevant to the Ignitor project are reported. These are included within the following sections of the present paper: main components issues, assembly and welding procedures; robotics criteria; non-linear feedback control; simulations with three-dimensional structures and disruption studies; ICRH and dedicated diagnostics systems; anomalous transport processes including self-organization for fusion burning regimes and the zero-dimensional model; tridimensional structures of the thermonuclear instability and control provisions; superconducting components of the present machine; envisioned experiments with high field superconducting magnets. © 2015 IAEA.
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- 2015
110. Experimental study of the propellant gas load required for pellet injection with ITER-relevant operating parameters
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C.R. Foust, Steven J. Meitner, Silvio Migliori, Antonio Frattolillo, Larry R. Baylor, S.K. Combs, M. S. Lyttle, Migliori, S., and Frattolillo, A.
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Propellant ,Nuclear and High Energy Physics ,Test facility ,Mechanical Engineering ,Nuclear engineering ,education ,technology, industry, and agriculture ,01 natural sciences ,010305 fluids & plasmas ,Nuclear Energy and Engineering ,0103 physical sciences ,Pellet ,Environmental science ,General Materials Science ,010306 general physics ,Civil and Structural Engineering - Abstract
An existing pipe gun test facility at ORNL was used for an experimental study of propellant gas loads required for ITER-relevant pellet injection, with the key objective of determining the minimal amount of gas required for optimal pellet speeds. Two pellet sizes were tested, with nominal 4.4 and 3.2 mm diameters comparable to pellets planned for fueling and ELM pacing in ITER, respectively. A novel scheme was used to freeze solid pellets from room temperature gas; this facilitated operations at higher temperatures (14.5 to 16.5 K, similar to those planned for extruder operations for ITER pellet injectors) and thus lower pellet breakaway pressures and gas loads. Most of the single-shot D2 pellet tests were carried out with a relatively low H2 propellant gas load of ∼0.0133 bar-L. Some limited testing was also carried out with a mixed propellant gas that consisted mostly of D2, which is more representative of the gas that will be used for ITER pellet injection. In testing it was found that this reference gas load resulted in pellet speeds in close proximity to a speed limit (∼300 m/s) previously determined in a series of tests with D2 pellets shot through a mock-up of the curved guide tubes planned for the ITER installation (for pellet fueling from the magnetic high-field side). The equipment, operations, and test results are presented and discussed, with emphasis on the relevance for ITER operations.
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- 2015
111. The role of medium size facilities in the HPC ecosystem: the case of the new CRESCO4 cluster integrated in the ENEAGRID infrastructure
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Giovanni Ponti, T. Bastianelli, B. Calosso, R. Guadagni, M. De Rosa, S. Magagnino, Samuele Pierattini, Andrea Quintiliani, Silvio Migliori, A. Vita, G. Aprea, P. De Michele, Agostino Funel, F. Poggi, Giovanni Bracco, M. Caporicci, Filippo Palombi, F. Simoni, Angelo Mariano, Graziano Furini, A. Rocchi, F. Ambrosino, C Scio, Salvatore Podda, A. Perozziello, Guido Guarnieri, S. Pecoraro, C. Mercuri, D. Abate, A. Italiano, Antonio Colavincenzo, G. Mencuccini, P. D'Angelo, P. Ornelli, Marta Chinnici, A. Cucurullo, F. Beone, R. Bertini, Dante Giammattei, Simone Giusepponi, Vita, A., Simoni, F., Scio, C., Rocchi, A., Quintiliani, A., Poggi, F., Podda, S., Pierattini, S., Perozziello, A., Pecoraro, S., Ornelli, P., Migliori, S., Mercuri, C., Mencuccini, G., Mariano, A., Magagnino, S., Italiano, A., Guarnieri, G., Guadagni, R., Giusepponi, S., Giammattei, D., Funel, A., De Michele, P., De Rosa, M., Dangelo, P., Cucurullo, A., Colavincenzo, A., Chinnici, M., Calosso, B., Caporicci, M., Bracco, G., Bertini, R., Beone, F., Bastianelli, T., Aprea, G., Ambrosino, F., Ponti, G., and Palombi, F.
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Large class ,supercomputing ,business.industry ,Computer science ,Distributed computing ,Cloud computing ,Linux clusters ,computer.software_genre ,HPC ,Linux cluster ,HPC Challenge Benchmark ,Scalability ,Operating system ,Cluster (physics) ,business ,computer - Abstract
Medium size HPC clusters play an important role in the HPC landscape in that they provide both the training environment for system scalability and a flexible production field for a large class of numerical problems. In this poster we present CRESCO4, the latest medium size HPC cluster purchased by ENEA, in operation since few months. CRESCO4 is part of a family of HPC systems, all integrated within ENEAGRID, a large infrastructure for cloud computing, which includes all the computational facilities installed at several ENEA sites in Italy.
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- 2014
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112. New developments, plasma physics regimes and issues for the Ignitor experiment
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Alfredo Pironti, A. Bianchi, S. Mantovani, Arnaud Ferrari, A. Tumino, Giuseppe Ambrosino, Bruno Coppi, M. Lazzaretti, A. DeVellis, Francesco Giammanco, Giovanna Cenacchi, P. Detragiache, Fabio Villone, Samuele Pierattini, P. Frosi, Silvio Migliori, Raffaele Albanese, G. De Tommasi, A. Airoldi, Enrico Costa, M. Sassi, A. Cardinali, G. Faelli, Antonio Frattolillo, F. Bombarda, G. Grasso, G. Ramogida, Marco Tavani, Guglielmo Rubinacci, Coppi, B., Airoldi, A., Albanese, Raffaele, Ambrosino, Giuseppe, Bombarda, F., Bianchi, A., Cardinali, A., Cenacchi, G., Costa, E., Detragiache, P., DE TOMMASI, Gianmaria, Devellis, A., Faelli, G., Ferrari, A., Frattolillo, A., Frosi, P., Giammanco, F., Grasso, G., Lazzaretti, M., Mantovani, S., Migliori, S., Pierattini, S., Pironti, Alfredo, Ramogida, G., Rubinacci, Guglielmo, Sassi, M., Tavani, M., Tumino, A., and Villone, F.
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Physics ,Nuclear and High Energy Physics ,Toroid ,Nuclear engineering ,Full scale ,Control reconfiguration ,Condensed Matter Physics ,IGNITOR ,law.invention ,Nuclear physics ,Ignition system ,Duty cycle ,law ,Magnet ,Water cooling - Abstract
The scientific goal of the Ignitor experiment is to approach, for the first time, the ignition conditions of a magnetically confined D-T plasma. The IGNIR collaboration between Italy and Russia is centred on the construction of the core of the Ignitor machine in Italy and its installation and operation within the Triniti site (Troitsk). A parallel initiative has developed that integrates this programme, involving the study of plasmas in which high-energy populations are present, with ongoing research in high-energy astrophysics, with a theory effort involving the National Institute for High Mathematics, and with INFN and the University of Pisa for the development of relevant nuclear and optical diagnostics. The construction of the main components of the machine core has been fully funded by the Italian Government. Therefore, considerable attention has been devoted towards identifying the industrial groups having the facilities necessary to build these components. An important step for the Ignitor programme is the adoption of the superconducting MgB2 material for the largest poloidal field coils (P14) that is compatible with the He-gas cooling system designed for the entire machine. The progress made in the construction of these coils is described. An important advance has been made in the reconfiguration of the cooling channels of the toroidal magnet that can double the machine duty cycle. A facility has been constructed to test the most important components of the ICRH system at full scale, and the main results of the tests carried out are presented. The main physics issues that the Ignitor experiment is expected to face are analysed considering the most recent developments in both experimental observations and theory for weakly collisional plasma regimes. Of special interest is the I-regime that has been investigated in depth only recently and combines advanced confinement properties with a high degree of plasma purity. This is a promising alternative to the high-density L-regime that had been observed by the Alcator experiment and whose features motivated the Ignitor project. The provisions that are incorporated in the machine design, and in that of the plasma chamber in particular, in order to withstand or prevent the development of macroscopic instabilities with deleterious amplitudes are presented together with relevant analyses. © 2013 IAEA, Vienna.
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- 2013
113. New Developments, Plasma Physics Regimes and Issues for the Ignitor Experiment
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B. Coppi, A. Airoldi, F. Bombarda, A. Cardinali, G. Cenacchi, E. Costa, P. Detragiache, A. DeVellis, G. Faelli, A. Ferrari, A. Frattolillo, P. Frosi, F. Giammanco, G. Grasso, S. Mantovani, S. Migliori, S. Pierattini, G. Ramogida, M. Sassi, M. Tavani, A. Tumino, F. Villone, ALBANESE, Raffaele, RUBINACCI, GUGLIELMO, Coppi, B., Airoldi, A., Albanese, Raffaele, Bombarda, F., Cardinali, A., Cenacchi, G., Costa, E., Detragiache, P., Devellis, A., Faelli, G., Ferrari, A., Frattolillo, A., Frosi, P., Giammanco, F., Grasso, G., Mantovani, S., Migliori, S., Pierattini, S., Ramogida, G., Rubinacci, Guglielmo, Sassi, M., Tavani, M., Tumino, A., and Villone, F.
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- 2012
114. Near Term Perspectives for Fusion Research and New Contributions by the Ignitor Program
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B. Coppi, A. Airoldi, S. Berta, A. Bianchi, F. Bombarda, A. Cardinali, G. Cenacchi, G. Clai, P. Detragiache, G. Faelli, A. Frattolillo, P. Frosi, G. Giunchi, G. Grasso, S. Mantovani, S. Migliori, R. Penco, S. Pierattini, G. Pizzicaroli, G. Ramogida, M. Sassi, F. Villone, M. Zucchetti, ALBANESE, Raffaele, RUBINACCI, GUGLIELMO, Coppi, B., Airoldi, A., Albanese, Raffaele, Berta, S., Bianchi, A., Bombarda, F., Cardinali, A., Cenacchi, G., Clai, G., Detragiache, P., Faelli, G., Frattolillo, A., Frosi, P., Giunchi, G., Grasso, G., Mantovani, S., Migliori, S., Penco, R., Pierattini, S., Pizzicaroli, G., Ramogida, G., Rubinacci, Guglielmo, Sassi, M., Villone, F., and Zucchetti, M.
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- 2010
115. Relevant Developments for the Ignitor Program and Burning Plasma Regimes of Special Interest
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B. Coppi, A. Airoldi, A. Bianchi, F. Bombarda, A. Cardinali, G. Cenacchi, A. Coletti, P. Detragiache, A. Frattolillo, R. Maggiora, S. Migliori, G. Pizzicaroli, G. Ramogida, M. Sassi, G. Toselli, S. Tosti, F. Villone, ALBANESE, Raffaele, RUBINACCI, GUGLIELMO, Coppi, B., Airoldi, A., Albanese, Raffaele, Bianchi, A., Bombarda, F., Cardinali, A., Cenacchi, G., Coletti, A., Detragiache, P., Frattolillo, A., Maggiora, R., Migliori, S., Pizzicaroli, G., Ramogida, G., Rubinacci, Guglielmo, Sassi, M., Toselli, G., Tosti, S., and Villone, F.
- Published
- 2008
116. Application of an OCT-based 3D reconstruction framework to the hemodynamic assessment of an ulcerated coronary artery plaque.
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Migliori S, Chiastra C, Bologna M, Montin E, Dubini G, Genuardi L, Aurigemma C, Mainardi L, Burzotta F, and Migliavacca F
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- Aged, Angiography, Humans, Hydrodynamics, Male, Patient-Specific Modeling, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease physiopathology, Hemodynamics, Imaging, Three-Dimensional, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic physiopathology, Tomography, Optical Coherence
- Abstract
The rupture of a vulnerable plaque, known as ulceration, is the most common cause of myocardial infarction. It can be recognized by angiographic features, such as prolonged intraluminal filling and delayed clearance of the contrast liquid. The diagnosis of such an event is an open challenge due to the limited angiographic resolution and acquisition frequency. The treatment of ulcerated plaques is an open discussion, due to the high heterogeneity and the lack of evidences that support particular strategies. Therefore, the therapeutic decision should follow a detailed investigation with angiography and intravascular imaging, such as optical coherence tomography (OCT), to locate the lesion, besides its geometric features and the lumen occlusion severity. The aim of this study is the application of a framework for the in-silico analysis of the disrupted hemodynamics due to an ulcerated lesion. The study employed a validated OCT-based reconstruction methodology and computational fluid dynamics (CFD) simulations for the computation of local hemodynamic quantities, such as wall shear stress. The reported findings, such as disrupted pre-operative flow conditions, proved the applicability of the developed framework for CFD analyses on complicated patient-specific anatomies that feature ulcerated plaques. The prediction of lesion expansion and the clinical decision making can benefit from a reliable computation of wall shear stress distributions that result from the peculiar anatomy of the lesion. The application of intravascular OCT imaging, high fidelity 3D reconstructions and CFD simulations might guide the treatment of such pathology., Competing Interests: Declaration of Competing Interest The authors have no professional or financial conflicts of interest to disclose., (Copyright © 2020. Published by Elsevier Ltd.)
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- 2020
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117. Automatic segmentation of optical coherence tomography pullbacks of coronary arteries treated with bioresorbable vascular scaffolds: Application to hemodynamics modeling.
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Bologna M, Migliori S, Montin E, Rampat R, Dubini G, Migliavacca F, Mainardi L, and Chiastra C
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- Absorbable Implants, Coronary Vessels surgery, Female, Humans, Male, Middle Aged, Algorithms, Blood Vessel Prosthesis, Coronary Angiography, Coronary Vessels diagnostic imaging, Hemodynamics, Models, Cardiovascular, Stents, Tomography, Optical Coherence
- Abstract
Background / Objectives: Automatic algorithms for stent struts segmentation in optical coherence tomography (OCT) images of coronary arteries have been developed over the years, particularly with application on metallic stents. The aim of this study is three-fold: (1) to develop and to validate a segmentation algorithm for the detection of both lumen contours and polymeric bioresorbable scaffold struts from 8-bit OCT images, (2) to develop a method for automatic OCT pullback quality assessment, and (3) to demonstrate the applicability of the segmentation algorithm for the creation of patient-specific stented coronary artery for local hemodynamics analysis., Methods: The proposed OCT segmentation algorithm comprises four steps: (1) image pre-processing, (2) lumen segmentation, (3) stent struts segmentation, (4) strut-based lumen correction. This segmentation process is then followed by an automatic OCT pullback image quality assessment. This method classifies the OCT pullback image quality as 'good' or 'poor' based on the number of regions detected by the stent segmentation. The segmentation algorithm was validated against manual segmentation of 1150 images obtained from 23 in vivo OCT pullbacks., Results: When considering the entire set of OCT pullbacks, lumen segmentation showed results comparable with manual segmentation and with previous studies (sensitivity ~97%, specificity ~99%), while stent segmentation showed poorer results compared to manual segmentation (sensitivity ~63%, precision ~83%). The OCT pullback quality assessment algorithm classified 7 pullbacks as 'poor' quality cases. When considering only the 'good' classified cases, the performance indexes of the scaffold segmentation were higher (sensitivity >76%, precision >86%)., Conclusions: This study proposes a segmentation algorithm for the detection of lumen contours and stent struts in low quality OCT images of patients treated with polymeric bioresorbable scaffolds. The segmentation results were successfully used for the reconstruction of one coronary artery model that included a bioresorbable scaffold geometry for computational fluid dynamics analysis., Competing Interests: The authors have declared that no competing interests exist.
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- 2019
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118. Patient-Specific Modeling of Stented Coronary Arteries Reconstructed from Optical Coherence Tomography: Towards a Widespread Clinical Use of Fluid Dynamics Analyses.
- Author
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Chiastra C, Migliori S, Burzotta F, Dubini G, and Migliavacca F
- Subjects
- Coronary Artery Disease physiopathology, Coronary Vessels physiopathology, Humans, Image Interpretation, Computer-Assisted, Predictive Value of Tests, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease surgery, Coronary Vessels diagnostic imaging, Coronary Vessels surgery, Models, Cardiovascular, Patient-Specific Modeling, Percutaneous Coronary Intervention instrumentation, Stents, Tomography, Optical Coherence
- Abstract
The recent widespread application of optical coherence tomography (OCT) in interventional cardiology has improved patient-specific modeling of stented coronary arteries for the investigation of local hemodynamics. In this review, the workflow for the creation of fluid dynamics models of stented coronary arteries from OCT images is presented. The algorithms for lumen contours and stent strut detection from OCT as well as the reconstruction methods of stented geometries are discussed. Furthermore, the state of the art of studies that investigate the hemodynamics of OCT-based stented coronary artery geometries is reported. Although those studies analyzed few patient-specific cases, the application of the current reconstruction methods of stented geometries to large populations is possible. However, the improvement of these methods and the reduction of the time needed for the entire modeling process are crucial for a widespread clinical use of the OCT-based models and future in silico clinical trials.
- Published
- 2018
- Full Text
- View/download PDF
119. A framework for computational fluid dynamic analyses of patient-specific stented coronary arteries from optical coherence tomography images.
- Author
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Migliori S, Chiastra C, Bologna M, Montin E, Dubini G, Aurigemma C, Fedele R, Burzotta F, Mainardi L, and Migliavacca F
- Subjects
- Blood Flow Velocity, Blood Vessel Prosthesis, Computer Simulation, Coronary Vessels pathology, Humans, Hydrodynamics, Image Interpretation, Computer-Assisted methods, Pattern Recognition, Automated methods, Phantoms, Imaging, Surgery, Computer-Assisted methods, Tomography, Optical Coherence instrumentation, Treatment Outcome, Coronary Circulation, Coronary Vessels physiopathology, Coronary Vessels surgery, Models, Cardiovascular, Patient-Specific Modeling, Stents, Tomography, Optical Coherence methods
- Abstract
The clinical challenge of percutaneous coronary interventions (PCI) is highly dependent on the recognition of the coronary anatomy of each individual. The classic imaging modality used for PCI is angiography, but advanced imaging techniques that are routinely performed during PCI, like optical coherence tomography (OCT), may provide detailed knowledge of the pre-intervention vessel anatomy as well as the post-procedural assessment of the specific stent-to-vessel interactions. Computational fluid dynamics (CFD) is an emerging investigational tool in the setting of optimization of PCI results. In this study, an OCT-based reconstruction method was developed for the execution of CFD simulations of patient-specific coronary artery models which include the actual geometry of the implanted stent. The method was applied to a rigid phantom resembling a stented segment of the left anterior descending coronary artery. The segmentation algorithm was validated against manual segmentation. A strong correlation was found between automatic and manual segmentation of lumen in terms of area values. Similarity indices resulted >96% for the lumen segmentation and >77% for the stent strut segmentation. The 3D reconstruction achieved for the stented phantom was also assessed with the geometry provided by X-ray computed micro tomography scan, used as ground truth, and showed the incidence of distortion from catheter-based imaging techniques. The 3D reconstruction was successfully used to perform CFD analyses, demonstrating a great potential for patient-specific investigations. In conclusion, OCT may represent a reliable source for patient-specific CFD analyses which may be optimized using dedicated automatic segmentation algorithms., (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
120. Reconstruction of stented coronary arteries from optical coherence tomography images: Feasibility, validation, and repeatability of a segmentation method.
- Author
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Chiastra C, Montin E, Bologna M, Migliori S, Aurigemma C, Burzotta F, Celi S, Dubini G, Migliavacca F, and Mainardi L
- Subjects
- Algorithms, Feasibility Studies, Humans, Reproducibility of Results, Coronary Vessels diagnostic imaging, Stents, Tomography, Optical Coherence methods
- Abstract
Optical coherence tomography (OCT) is an established catheter-based imaging modality for the assessment of coronary artery disease and the guidance of stent placement during percutaneous coronary intervention. Manual analysis of large OCT datasets for vessel contours or stent struts detection is time-consuming and unsuitable for real-time applications. In this study, a fully automatic method was developed for detection of both vessel contours and stent struts. The method was applied to in vitro OCT scans of eight stented silicone bifurcation phantoms for validation purposes. The proposed algorithm comprised four main steps, namely pre-processing, lumen border detection, stent strut detection, and three-dimensional point cloud creation. The algorithm was validated against manual segmentation performed by two independent image readers. Linear regression showed good agreement between automatic and manual segmentations in terms of lumen area (r>0.99). No statistically significant differences in the number of detected struts were found between the segmentations. Mean values of similarity indexes were >95% and >85% for the lumen and stent detection, respectively. Stent point clouds of two selected cases, obtained after OCT image processing, were compared to the centerline points of the corresponding stent reconstructions from micro computed tomography, used as ground-truth. Quantitative comparison between the corresponding stent points resulted in median values of ~150 μm and ~40 μm for the total and radial distances of both cases, respectively. The repeatability of the detection method was investigated by calculating the lumen volume and the mean number of detected struts per frame for seven repeated OCT scans of one selected case. Results showed low deviation of values from the median for both analyzed quantities. In conclusion, this study presents a robust automatic method for detection of lumen contours and stent struts from OCT as supported by focused validation against both manual segmentation and micro computed tomography and by good repeatability.
- Published
- 2017
- Full Text
- View/download PDF
121. A method for coronary bifurcation centerline reconstruction from angiographic images based on focalization optimization.
- Author
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Montin E, Migliori S, Chiastra C, Credi C, Fedele R, Aurigemma C, Levi M, Burzotta F, Migliavacca F, and Mainardi LT
- Subjects
- Algorithms, Computer-Aided Design, Coronary Angiography, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Tomography, Optical Coherence, X-Ray Microtomography, Coronary Vessels diagnostic imaging
- Abstract
A method for the reconstruction of a vessel centerline from angiographic images is outlined in this work. A typical coronary artery segment with bifurcations was emulated with a 3D printed static phantom and several angiograms were acquired at various angular positions on the C-Arm. The effectiveness of the reconstruction turned out to be largely influenced by the intrinsic parameters of the angiographic system, particularly the homogeneous coordinates system scaling factor λ. Therefore, recourse was made to a heuristic optimization method to estimate the optimal value of λ for each view. We measured the reliability of the reconstruction method by varying the fitness function of the optimization step and measuring the distances of 8 test points in comparison to the corresponding points identified in the μCT centerline. Preliminary results showed that, with an adequate number of views, the adoption of the optimal fitness function allowed the median distance error to be decreased below the acceptance threshold of 10%. As expected, the reliability of the method is improved by increasing the number of processed views.
- Published
- 2016
- Full Text
- View/download PDF
122. [A double blind randomised clinical trial to assess the efficacy of the treatments of the superficial pressure sores].
- Author
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Di Giulio P, Saiani L, Laquintana D, Palese A, Perli S, Andreatta M, Rosa F, Chini P, Soraperra F, Ventura I, Suriani C, Romani S, Zancarli M, Martini M, Partel F, Bassetti S, Kaisermann R, Bortolotti C, Gianordoli M, Rizzoli I, Nardelli R, Pellizzari E, Valduga E, Castaman M, Pordenon M, Beltrame M, Bertolo C, Casasola E, Del Pin P, Giolo S, Marcatti E, Pecini D, Rodaro M, Zanon C, Stefanon L, Covre L, Babbo C, Martin I, Roilo A, Zanutel M, Sabbadin S, Boin L, Caron A, Martignago E, Venturin V, Greggio A, Frigo P, Lazzaron D, Tonietto A, Zanin B, Zorzi S, Zuanon A, Salmaso D, Frison T, Marin I, Buosi A, Fiorese E, Gasparin D, Goat B, Saccardo G, Simonetto O, Gomiero S, Baccara N, Ghirardello L, Niolu M, Silvestri S, Buffon ML, Casson P, Santantonio R, Albore P, Mazzorana E, Terziariol L, Bulgarelli G, Barani E, Gasparini P, Migliori S, Sasso E, Marfisi RM, Tognoni G, Sgaroni G, Noro G, and Mattiuzzo M
- Subjects
- Aged, Aged, 80 and over, Double-Blind Method, Humans, Male, Phytotherapy, Plant Preparations therapeutic use, Pressure Ulcer drug therapy, Triticum
- Abstract
In spite of the progresses of knowledge and care, pressure sores continue to be a clinically relevant problem. A double blind randomised controlled trial was organised to assess the efficacy of triticum vulgaris (Fitostimoline) vs placebo in the re-epithelisation of superficial pressure sores. Patients with stage NPUAP II or superficial pressure sores, with an expected survival of more than 3 months and eligible for a follow-up up to 8 weeks were included, over a period of 2 years in 46 clinical sites. The protocol was approved by local ethical committees and informed consent was obtained before randomisation. Medications were performed by nurses if the patient was hospitalised and by nurses or properly instructed caregivers at home. Weekly follow-up controls were assumed by nurses. Out of the 294 randomised patients 270 were included in the analyses. The two groups are comparable for the main characteristics except for Norton Scale mean values, less severe in the group assigned to active treatment (10.1+/-3.7 vs 8.9+/-3.2). The mean follow-up was of 3.8 and 4.2 weeks with a mean duration of 26+/-18 and 29+/-18 days for the experimental group and controls respectively. Seventy-six patients in the treatment group and controls (58.0 and 54.7) had their lesions re-epithelized. Adjusting results for age, initial Norton and Push scores there are no differences between treated and controls (OR 0.99 95% IC 0.60-1.67). This multicentre study, sponsored by a research group of nurses, failed to support the hypothesis that triticum vulgaris, the active component of the product Fitostimoline, given on top of recommended treatment, provides a specific therapeutic advantage in terms of frequency and timing of re-epithelization in superficial pressure sores.
- Published
- 2004
123. Laparoscopic complete excision of a splenic epidermoid cyst.
- Author
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Soares RL Jr, Balder DA, Migliori SJ, and Amaral JF
- Subjects
- Adult, Epidermal Cyst diagnosis, Female, Humans, Splenic Diseases diagnosis, Epidermal Cyst surgery, Laparoscopy, Splenic Diseases surgery
- Abstract
Splenic epidermoid cysts are rare lesions traditionally treated by splenectomy. Concerns about overwhelming postsplenectomy sepsis have led to the development of splenic preservation procedures in the treatment of cystic diseases of the spleen. We present the first case report of successful laparoscopic complete excision of a splenic epidermoid cyst.
- Published
- 1998
- Full Text
- View/download PDF
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