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106 results on '"Michelle Puchowicz"'

101. Preventative effect of mitochondrial antioxidants in apoe deficiency mouse model of brain hypoperfusion

Author

J. C. de la Torre, Kui Xu, Mark A. Smith, Sandra L. Siedlak, Jiankang Liu, J. Koistinaho, Bruce N. Ames, Michelle Puchowicz, Gjumrakch Aliev, Justin C. Shenk, Joseph C. LaManna, George Perry, and Mark E. Obrenovich

Subjects
Apolipoprotein E, Neurology, Cerebral hypoperfusion, business.industry, Medicine, Neurology (clinical), business, Neuroscience
Published
2009
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102. DOES THE OXIDATIVE STRESS AND CEREBRAL ATHEROSCLEROSIS INITIATE BRAIN HYPOPERFUSION AND THE DEVELOPMENT OF ALZHEIMER DISEASE?

Author

Bruce N. Ames, Kui Xu, Michelle Puchowicz, Eldar Gasimov, Mark A. Smith, J. Liu, Joseph C. LaManna, Mark E. Obrenovich, Gjumrakch Aliev, Sandra L. Siedlak, Justin C. Shenk, and George Perry

Subjects
Pathology, medicine.medical_specialty, Cerebral hypoperfusion, business.industry, General Medicine, medicine.disease_cause, medicine.disease, Cerebral atherosclerosis, Internal Medicine, medicine, Alzheimer's disease, Cardiology and Cardiovascular Medicine, business, Oxidative stress
Published
2008
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103. PO13-357 THE PRIMARY PATHOGENETIC ROLE OF VASCULAR HYPOPERFUSION, AND OXIDATIVE STRESS IN ALZHEIMER DISEASE

Author

Robert P. Friedland, Mark A. Smith, Joseph C. LaManna, Mark E. Obrenovich, S.G. Chen, Kui Xu, J. Koistinaho, Justin C. Shenk, George Perry, Gjumrakch Aliev, Michelle Puchowicz, J.C. DeLaTore, J. Liu, Bruce N. Ames, and Sandra L. Siedlak

Subjects
Pathology, medicine.medical_specialty, Primary (chemistry), business.industry, General Medicine, medicine.disease, medicine.disease_cause, Internal Medicine, medicine, Alzheimer's disease, Cardiology and Cardiovascular Medicine, business, Perfusion, Oxidative stress
Published
2007
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106. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise

Author

Paula Mera, Sarah J. Mitchell, Alain Lacampagne, Richard N. Kitsis, Julie A. Mattison, Mathieu Ferron, Kathrin Laue, Pawel Szulc, Marta Galán-Díez, Irwin J. Kurland, Jianwen Wei, Michelle Puchowicz, Richard A. Friedman, Gerard Karsenty, Yun Chen, Justine Bacchetta, Cyril Confavreux, Rafael de Cabo, Christopher Torsitano, Timothy E. McGraw, Universitat de Barcelona, Columbia University Medical Center [New York], New York Presbyterian Hospital, Medical Center, Columbia University [New York], Hospices Civils de Lyon (HCL), Hospital Universitario de la Princesa, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), National Institute on Aging, Baltimore, National Institute on Aging, NIH, Baltimore, Albert Einstein College of Medicine [New York], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, National Institutes of Health [Bethesda] (NIH), Columbia University Irving Medical Center (CUIMC), Weill Medical College of Cornell University [New York], Case Western Reserve University [Cleveland], Department of Genetics and Development, Hospital Universitario de La Princesa, and MORNET, Dominique

Subjects
0301 basic medicine, Aging, Physiology, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Muscle Fibers, Skeletal, Ossification, 0302 clinical medicine, Insulina, Insulin, Ossificació, musculoskeletal, neural, and ocular physiology, Fatty Acids, Adaptation, Physiological, [SDV] Life Sciences [q-bio], Cell metabolism, Osteocalcin, Signal Transduction, musculoskeletal diseases, medicine.medical_specialty, GPRC6A, 030209 endocrinology & metabolism, Exercici, Carbohydrate metabolism, Biology, Models, Biological, Article, Bone and Bones, Peptide hormones, 03 medical and health sciences, Internal medicine, Physical Conditioning, Animal, Myokine, medicine, Aerobic exercise, Humans, Animals, Obesity, Interleukin 6, Molecular Biology, Exercise, Catabolism, Interleukin-6, Cell Biology, Hormones peptídiques, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Glucose, Glucosa, biology.protein, Adaptation
Abstract

International audience; Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin plummet early during adulthood in mice, monkeys, and humans of both genders. Exploring these observations revealed that osteocalcin signaling in myofibers is necessary for adaptation to exercise by favoring uptake and catabolism of glucose and fatty acids, the main nutrients of myofibers. Osteocalcin signaling in myofibers also accounts for most of the exercise-induced release of interleukin-6, a myokine that promotes adaptation to exercise in part by driving the generation of bioactive osteocalcin. We further show that exogenous osteocalcin is sufficient to enhance the exercise capacity of young mice and to restore to 15-month-old mice the exercise capacity of 3-month-old mice. This study uncovers a bone-to-muscle feedforward endocrine axis that favors adaptation to exercise and can reverse the age-induced decline in exercise capacity.

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