980 results on '"Metter, E. Jeffrey"'
Search Results
102. TNFα −308G/AAnd 1110 −1082A/G Polymorphisms Are Associated With Muscle Mass In Humans: 2494: Board #41 June 2 9:30 AM - 11:00 AM
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Liu, Dongmei, Metter, E. Jeffrey, Ferrucci, Luigi, and Roth, Stephen M.
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- 2007
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103. Myostatin Related Gene Associations with Muscle Mass and Strength in Humans: 565: May 30 1:30 PM - 1:45 PM
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Walsh, Sean, Metter, E. Jeffrey, Ferrucci, Luigi, and Roth, Stephen M.
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- 2007
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104. Re: Detection of Life-Threatening Prostate Cancer With Prostate-Specific Antigen Velocity During a Window of Curability
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Carter, H. Ballentine, Ferrucci, Luigi, Kettermann, Anna, Landis, Patricia, Wright, James, Epstein, Jonathan I., Trock, Bruce J., and Metter, E. Jeffrey
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- 2007
105. Longitudinal change in forced expiratory volume in healthy, non-smoking men and women: the Baltimore longitudinal study of aging
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Pearson, Jay D., Kao, Stephanie Y., Brant, Larry J., Metter, E. Jeffrey, Tockman, Melvyn S., and Fozard, James L.
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Forced expiratory volume -- Research ,Sex differences -- Health aspects ,Age -- Health aspects ,Biological sciences - Abstract
Studies have found both gender- and age-related differences in rates of forced expiratory volume at one second (FEV1). FEV1 decline was found to be slower in women than in men, but not at a statistically significant rate. Variability between subjects is also lower in women than in men, and rises with age.
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- 1998
106. Detection of Life-Threatening Prostate Cancer With Prostate-Specific Antigen Velocity During a Window of Curability
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Carter, H. Ballentine, Ferrucci, Luigi, Kettermann, Anna, Landis, Patricia, Wright, E. James, Epstein, Jonathan I., Trock, Bruce J., and Metter, E. Jeffrey
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- 2006
107. Metabolic Factors Associated with Benign Prostatic Hyperplasia
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Parsons, J Kellogg, Carter, H Ballentine, Partin, Alan W., Windham, B Gwen, Metter, E Jeffrey, Ferrucci, Luigi, Landis, Patricia, and Platz, Elizabeth A.
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- 2006
108. Age and sex affect human muscle fibre adaptations to heavy-resistance strength training
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Martel, Gregory F., Roth, Stephen M., Ivey, Frederick M., Lemmer, Jeffrey T., Tracy, Brian L., Hurlbut, Diane E., Metter, E. Jeffrey, Hurley, Ben F., and Rogers, Marc A.
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- 2006
109. Age-associated loss of power and strength in the upper extremities in women and men
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Metter, E. Jeffrey, Conwit, Robin, Tobin, Jordan, and Fozard, James L.
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Physical fitness -- Physiological aspects ,Extremities, Upper -- Physiological aspects ,Aging -- Physiological aspects ,Health ,Seniors - Abstract
Cross-sectional and longitudinal age-associated reductions in power and isometric strength are described for the upper extremities. Over a 25-year period, repeated measures were taken approximately every 2 years from men and women in the Baltimore Longitudinal Study of Aging (BLSA). The longitudinal measures covered an average 9.6 years, range 1-25 years for men and an average 4.6 years, range 1-8 years for women. Strength and power declined beginning by age 40 in both women and men. Thereafter, power declined about 10% more than strength in men, while no significant differences were found in women. Age had a statistically independent influence on strength and power measures after adjusting for gender, height, weight, caloric expenditure, and muscle mass. Twenty-five-year longitudinal analyses in men confirmed the declines observed cross-sectionally, while no changes were observed in women over the 4-5 years of longitudinal data available. Further longitudinal studies are needed to understand the relationships between strength and power losses with age in women. The differences between power and strength changes with age in men argue for the importance of factors other than strength affecting power.
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- 1997
110. Longitudinal changes in smell identification
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Ship, Jonathan A., Pearson, Jay D., Cruise, Laura J., Brant, Larry J., and Metter, E. Jeffrey
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Olfactometry -- Research ,Aging -- Physiological aspects ,Health ,Seniors - Abstract
Background. Cross-sectional studies have demonstrated that olfactory function diminishes with increasing age, which may impact on the safety and quality of life of older persons. To date, however, there have been no published longitudinal studies on olfaction. The purpose of this study was to examine the influence of age and gender on smell identification over a 3-year period in a group of generally healthy men and women. Methods. Males (n = 85) and females (n = 76) between the ages of 19 and 95 years were administered the University of Pennsylvania Smell Identification Test (SIT) over a 3-year span as part of the oral physiology component of the Baltimore Longitudinal Study of Aging. A linear mixed-effects regression model was used to determine how longitudinal changes in SIT scores differ with respect to gender, history of medical problems and use of prescription medications. Results. Over the 3-year period, SIT scores diminished progressively with increased age. Women and men in the eighth decade of life experienced a decline of greater than one SIT print per year. Females consistently performed better than males in smell identification. Similar results were obtained regardless of medical problems or medication usage. Conclusions. These results extend the conclusions of previous cross-sectional olfactory studies and indicate that smell identification deteriorates progressively with greater age. Furthermore, age-related declines in olfaction occur even in the absence of overt medical problems.
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- 1996
111. The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies
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Watts, Eleanor L., Perez-Cornago, Aurora, Appleby, Paul N., Albanes, Demetrius, Ardanaz, Eva, Black, Amanda, Bueno-de-Mesquita, H. Bas, Chan, June M., Chen, Chu, Chubb, S. A. Paul, Cook, Michael B., Deschasaux, Melanie, Donovan, Jenny L., English, Dallas R., Flicker, Leon, Freedman, Neal D., Galan, Pilar, Giles, Graham G., Giovannucci, Edward L., Gunter, Marc J., Habel, Laurel A., Häggström, Christel, Haiman, Christopher, Hamdy, Freddie C., Hercberg, Serge, Holly, Jeff M., Huang, Jiaqi, Huang, Wen-Yi, Johansson, Mattias, Kaaks, Rudolf, Kubo, Tatsuhiko, Lane, J. Athene, Layne, Tracy M., Le Marchand, Loic, Martin, Richard M., Metter, E. Jeffrey, Mikami, Kazuya, Milne, Roger L., Morris, Howard A., Mucci, Lorelei A., Neal, David E., Neuhouser, Marian L., Oliver, Steven E., Overvad, Kim, Ozasa, Kotaro, Pala, Valeria, Pernar, Claire H., Pollak, Michael, Rowlands, Mari-Anne, Schaefer, Catherine A., Schenk, Jeannette M., Stattin, Pär, Tamakoshi, Akiko, Thysell, Elin, Touvier, Mathilde, Trichopoulou, Antonia, Tsilidis, Konstantinos K., Van Den Eeden, Stephen K., Weinstein, Stephanie J., Wilkens, Lynne, Yeap, Bu B., Key, Timothy J., Allen, Naomi E., Travis, Ruth C., Watts, Eleanor L., Perez-Cornago, Aurora, Appleby, Paul N., Albanes, Demetrius, Ardanaz, Eva, Black, Amanda, Bueno-de-Mesquita, H. Bas, Chan, June M., Chen, Chu, Chubb, S. A. Paul, Cook, Michael B., Deschasaux, Melanie, Donovan, Jenny L., English, Dallas R., Flicker, Leon, Freedman, Neal D., Galan, Pilar, Giles, Graham G., Giovannucci, Edward L., Gunter, Marc J., Habel, Laurel A., Häggström, Christel, Haiman, Christopher, Hamdy, Freddie C., Hercberg, Serge, Holly, Jeff M., Huang, Jiaqi, Huang, Wen-Yi, Johansson, Mattias, Kaaks, Rudolf, Kubo, Tatsuhiko, Lane, J. Athene, Layne, Tracy M., Le Marchand, Loic, Martin, Richard M., Metter, E. Jeffrey, Mikami, Kazuya, Milne, Roger L., Morris, Howard A., Mucci, Lorelei A., Neal, David E., Neuhouser, Marian L., Oliver, Steven E., Overvad, Kim, Ozasa, Kotaro, Pala, Valeria, Pernar, Claire H., Pollak, Michael, Rowlands, Mari-Anne, Schaefer, Catherine A., Schenk, Jeannette M., Stattin, Pär, Tamakoshi, Akiko, Thysell, Elin, Touvier, Mathilde, Trichopoulou, Antonia, Tsilidis, Konstantinos K., Van Den Eeden, Stephen K., Weinstein, Stephanie J., Wilkens, Lynne, Yeap, Bu B., Key, Timothy J., Allen, Naomi E., and Travis, Ruth C.
- Abstract
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
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- 2019
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112. Response stability and reliability in longitudinal health evaluations
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Metter, E. Jeffrey, Metter, E. L., Costa, Jr, P. T., Brant, L. J., Zonderman, A., and Fozard, J. L.
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- 1992
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113. Prostate-specific Antigen and All-Cause Mortality: Results From the Baltimore Longitudinal Study On Aging
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Carter, H. Ballentine, Metter, E. Jeffrey, Wright, James, Landis, Patricia, Platz, Elizabeth, and Walsh, Patrick C.
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- 2004
114. Regional bone mineral density after resistive training in young and older men and women
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Ryan, Alice S., Ivey, Fred M., Hurlbut, Diane E., Martel, Gregory F., Lemmer, Jeffrey T., Sorkin, John D., Metter, E. Jeffrey, Fleg, Jerome L., and Hurley, Ben F.
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- 2004
115. A Home-Based Pedometer-Driven Walking Program to Increase Physical Activity in Older Adults with Osteoarthritis of the Knee: A Preliminary Study
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Talbot, Laura A., Gaines, Jean M., Huynh, Tu N., and Metter, E. Jeffrey
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- 2003
116. Postflight balance control recovery in an elderly astronaut: a case report
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Paloski, William H, Black, F. Owen, and Metter, E. Jeffrey
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Life Sciences (General) - Abstract
OBJECTIVE: To examine the sensorimotor adaptive response of a 77-year-old man exposed to the gravito-inertial challenges of orbital space flight. STUDY DESIGN: Prospective case study with retrospective comparisons. SETTING: NASA Neurosciences Laboratory (Johnson Space Center) and Baseline Data Collection Facility (Kennedy Space Center). PRIMARY PARTICIPANT: One 77-year-old male shuttle astronaut. INTERVENTION: Insertion into low Earth orbit was used to remove gravitational stimuli and thereby trigger sensorimotor adaptation to the microgravity environment. Graviceptor stimulation was reintroduced at landing, and sensorimotor readaptation to the terrestrial environment was tracked to completion. MAIN OUTCOME MEASURES: Computerized dynamic posturography tests were administered before and after orbital flight to determine the magnitude and time course of recovery. RESULTS: The elderly astronaut exhibited balance control performance decrements on landing day; however, there were no significant differences between his performance and that of younger astronauts tested on the same shuttle mission or on previous shuttle missions of similar duration. CONCLUSIONS: These results demonstrate that the physiological changes attributed to aging do not necessarily impair adaptive sensorimotor control processes.
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- 2004
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117. Longitudinal Assessment of Serum Free Testosterone Concentration Predicts Memory Performance and Cognitive Status in Elderly Men
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Moffat, Scott D., Zonderman, Alan B., Metter, E Jeffrey, Blackman, Marc R., Harman, S Mitchell, and Resnick, Susan M.
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- 2002
118. Biomarkers of Caloric Restriction May Predict Longevity in Humans
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Roth, George S., Lane, Mark A., Ingram, Donald K., Mattison, Julie A., Elahi, Dariush, Tobin, Jordan D., Muller, Denis, and Metter, E. Jeffrey
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- 2002
119. The relationship of arthritis self-efficacy to functional performance in older men and women with osteoarthritis of the knee
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Gaines, Jean M., Talbot, Laura A., and Metter, E. Jeffrey
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- 2002
120. Muscle Size Responses to Strength Training in Young and Older Men and Women
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Roth, Stephen M., Ivey, Fred M., Martel, Greg F., Lemmer, Jeff T., Hurlbut, Diane E., Siegel, Eliot L., Metter, E. Jeffrey, Fleg, Jerome L., Fozard, James L., Kostek, Matthew C., Wernick, David M., and Hurley, Ben F.
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- 2001
121. Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
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Harman, S Mitchell, Metter, E Jeffrey, Tobin, Jordan D, Pearson, Jay, and Blackman, Marc R
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- 2001
122. How comparable are healthy 60- and 80-year-old men?
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Metter, E. Jeffrey, Walega, David, Metter, Elayne L., Pearson, Jay, Brant, Larry J., Hiscock, Barbara S., and Fozard, James L.
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Aged men -- Research ,Age -- Health aspects ,Blood pressure -- Measurement ,Blood cholesterol -- Measurement ,Health status indicators -- Evaluation ,Health ,Seniors - Published
- 1992
123. Longitudinal evaluation of prostate-specific antigen levels in men with and without prostate disease
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Carter, H. Ballentine, Pearson, Jay D., Metter, E. Jeffrey, Brant, Larry J., Chan, Daniel W., Andres, Reubin, Fozard, James L., and Walsh, Patrick C.
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Prostate diseases -- Physiological aspects ,Tissue specific antigens ,Prostate cancer -- Diagnosis - Abstract
Increased blood levels of prostate-specific antigen (PSA) as men age may indicate greater risk for developing prostate cancer and other prostate diseases than in men with lower blood levels of PSA. Of 54 men whose blood levels of androgen and PSA were measured over seven to 25 years, 16 did not develop prostate disease, 20 developed benign prostatic hyperplasia (enlargement) (BPH), and 18 developed prostate cancer. Men who developed prostate cancer had a more rapid increase in PSA levels with age than men who developed BPH. Men who developed BPH had a more rapid increase in PSA levels with age than men who did not develop prostate disease. Five years before diagnosis, changes in PSA levels among men who developed BPH were approximately the same as those of men who did not develop prostate disease. The PSA levels of men who developed prostate cancer increased at a much more rapid rate compared to the other two groups, however.
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- 1992
124. Serum Levels of Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-3, and Prostate-Specific Antigen as Predictors of Clinical Prostate Cancer
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Harman, S Mitchell, Metter, E Jeffrey, Blackman, Marc R, Landis, Patricia K, and Carter, H Ballentine
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- 2000
125. Age and gender responses to strength training and detraining
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LEMMER, JEFF T., HURLBUT, DIANE E., MARTEL, GREG F., TRACY, BRIAN L., EY, FRED M., IV, METTER, E. JEFFREY, FOZARD, JAMES L., FLEG, JEROME L., and HURLEY, BEN F.
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- 2000
126. Leisure-time physical activities and their relationship to cardiorespiratory fitness in healthy men and women 18–95 years old
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TALBOT, LAURA A., METTER, E. JEFFREY, and FLEG, JEROME L.
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- 2000
127. Prostate-Specific Antigen Testing of Older Men
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Carter, H. Ballentine, Landis, Patricia K., Metter, E. Jeffrey, Fleisher, Lee A., and Pearson, Jay D.
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- 1999
128. Temporoparietal cortex in aphasia: evidence from positron emission tomography
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Metter, E. Jeffrey, Hanson, Wayne R., Jackson, Catherine A., Kempler, Daniel, van Lancker, Diana, Mazziotta, John C., and Phelps, Michael E.
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PET imaging ,Language disorders -- Causes of ,Aphasia -- Causes of ,Brain damage ,Brain -- Localization of functions ,Health - Abstract
There is a fundamental disagreement among those who study language disorders. One school of thought holds to a unitary, holistic, or nonsyndrome approach, which notes the similarities among aphasic patients. This approach is supported by the inability to predict aphasic symptoms from information about the site of the injury, indicating that there is no strict localization of language function. The other school of thought is that multiple and distinct aphasic syndromes exist, which can be observed in the clinical differences among patients. Also, damage to distinct brain regions produces specific dysfunctions. Various areas of the brain are associated with different language functions, with no single region being critical. Part of the problem in determining which view is correct is that it is possible to specify where the brain has been injured, but the functional consequences cannot be so easily measured. Positron emission tomographic (PET) examination of glucose metabolism in the temporoparietal region of the brain can locate areas of abnormal functioning, and help to provide a solution to this puzzle. The authors searched for a constant glucose metabolic abnormality across all major types of chronic aphasia in 44 patients. The results support the concept of a single location of functional abnormality in aphasia. The type and the extent of language dysfunction seem dependent on a complex relationship between the regions of structural damage, their effects on temporoparietal function, and the effects of these two on the rest of the brain. The data support a two-compartment model of aphasia, in which the temporoparietal region regulates the linguistic process, and the frontal lobe controls motor and planning processes that allow the task of speaking to be carried out. (Consumer Summary produced by Reliance Medical Information, Inc.)
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- 1990
129. Low Free Testosterone and Prostate Cancer Risk : A Collaborative Analysis of 20 Prospective Studies
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Watts, Eleanor L., Appleby, Paul N., Perez-Cornago, Aurora, Bueno-de-Mesquita, H. Bas, Chan, June M., Chen, Chu, Cohn, Barbara A., Cook, Michael B., Flicker, Leon, Freedman, Neal D., Giles, Graham G., Giovannucci, Edward, Gislefoss, Randi E., Hankey, Graeme J., Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N., Kubo, Tatsuhiko, Le Marchand, Loic, Luben, Robert N., Luostarinen, Tapio, Mannisto, Satu, Metter, E. Jeffrey, Mikami, Kazuya, Milne, Roger L., Ozasa, Kotaro, Platz, Elizabeth A., Quiros, J. Ramon, Rissanen, Harri, Sawada, Norie, Stampfer, Meir, Stanczyk, Frank Z., Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M., Thompson, Ian M., Tsilidis, Konstantinos K., Tsugane, Shoichiro, Ursin, Giske, Vatten, Lars, Weiss, Noel S., Yeap, Bu B., Allen, Naomi E., Key, Timothy J., and Travis, Ruth C.
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Adult ,Male ,Urologic Diseases ,Aging ,Time Factors ,Epidemiology ,Clinical Sciences ,FLOATING ABSOLUTE RISK ,Down-Regulation ,Risk Assessment ,Pooled analysis ,SEX STEROID ASSAYS ,Risk Factors ,Clinical Research ,Urologi och njurmedicin ,Humans ,2.1 Biological and endogenous factors ,Urology and Nephrology ,Sex hormones ,Testosterone ,Prospective Studies ,Aetiology ,Aged ,Cancer ,PREVENTION TRIAL ,Science & Technology ,Prostate cancer ,Prevention ,ANDROGEN RECEPTOR ,Prostatic Neoplasms ,MEN ,1103 Clinical Sciences ,MASS-SPECTROMETRY ,Androgens Pooled analysis ,Middle Aged ,Protective Factors ,Urology & Nephrology ,SERUM TESTOSTERONE ,Case-Control Studies ,Androgens ,FINASTERIDE ,CLINICAL-IMPLICATIONS ,HORMONES ,Neoplasm Grading ,Life Sciences & Biomedicine ,Prospective studies ,Biomarkers - Abstract
Background Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. Objective To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Design, setting, and participants Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Outcome measurements and statistical analysis Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Results and limitations Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR = 0.77, 95% confidence interval [CI] 0.69–0.86; p < 0.001) compared with men with higher concentrations (2nd–10th tenths of the distribution). Heterogeneity was present by tumour grade (phet = 0.01), with a lower risk of low-grade disease (OR = 0.76, 95% CI 0.67–0.88) and a nonsignificantly higher risk of high-grade disease (OR = 1.56, 95% CI 0.95–2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Conclusions Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. Patient summary In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer. © 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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- 2018
130. Reply to
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Alsherbini, Khalid A., primary, Metter, E. Jeffrey, additional, Foreman, Brandon P., additional, and Privitera, Michael D., additional
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- 2019
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131. Self-Managed Strength Training for Active Duty Military With a Knee Injury: A Randomized Controlled Pilot Trial
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Talbot, Col, USAFR (Ret.), Laura A, primary, Brede, Emily, primary, Price, Marquita N, primary, Zuber, Pilar d, primary, and Metter, E Jeffrey, primary
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- 2019
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132. Unimpaired Neuro-Adaptive Plasticity in an Elderly Astronaut
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Paloski, William H, Black, F. Owen, Metter, E. Jeffrey, and Dawson, David L
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Aerospace Medicine - Abstract
Quantitative analyses of a 77 year old astronaut's balance control performances on a standardized test battery revealed few differences between his neuro-adaptive responses to space flight and those of a group of younger astronauts tested following missions of similar duration. This finding suggests that the physiological changes associated with age do not necessarily impair adaptive plasticity in the human following removal and subsequent reintroduction of gravity.
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- 1999
133. Prostate Specific Antigen Predicts the Long-Term Risk of Prostate Enlargement: Results from the Baltimore Longitudinal Study of Aging
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WRIGHT, E. JAMES, FANG, JUNYONG, METTER, E. JEFFREY, PARTIN, ALAN W., LANDIS, PATRICIA, CHAN, DANIEL W., and CARTER, H. BALLENTINE
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- 2002
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134. Predictors for Tracheostomy with External Validation of the Stroke-Related Early Tracheostomy Score (SETscore)
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Alsherbini, Khalid, primary, Goyal, Nitin, additional, Metter, E. Jeffrey, additional, Pandhi, Abhi, additional, Tsivgoulis, Georgios, additional, Huffstatler, Tracy, additional, Kelly, Hallie, additional, Elijovich, Lucas, additional, Malkoff, Marc, additional, and Alexandrov, Andrei, additional
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- 2018
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135. Tu1782 - Tofacitinib Reduces Inflammatory Biomarkers in Ex Vivo Intestinal Tissue from Patients with Ulcerative Colitis and Healthy Controls
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Brand, Rhonda, primary, Siegel, Aaron, additional, Myerski, Ashley, additional, Engstrom, Jarret, additional, Metter, E. Jeffrey, additional, Brand, Randall, additional, Edick, Stacey, additional, DeBlasio, Weiping, additional, Cranston, Ross, additional, Regueiro, Miguel D., additional, Binion, David G., additional, Biswas, Nabanita, additional, Schwartz, Marc, additional, Moore, Beverley, additional, and McGowan, Ian, additional
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- 2018
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136. Abstract WP215: Geospatial Visualization of Mobile Stroke Unit Dispatches: A Method to Optimize Service Performance
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Rhudy, James P, primary, Alexandrov, Anne W, additional, Rike, Joseph, additional, Bryndziar, Tomas, additional, Hossein Zadeh Maleki, Ana, additional, Swatzell, Victoria, additional, Dusenbury, Wendy, additional, Metter, E. Jeffrey, additional, and Alexandrov, Andrei V, additional
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- 2018
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137. Geospatial Visualization of Mobile Stroke Unit Dispatches: A Method to Optimize Service Performance
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Rhudy Jr., James P., primary, Alexandrov, Anne W., additional, Rike, Joseph, additional, Bryndziar, Tomas, additional, Hossein Zadeh Maleki, Ana, additional, Swatzell, Victoria, additional, Dusenbury, Wendy, additional, Metter, E. Jeffrey, additional, and Alexandrov, Andrei V., additional
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- 2018
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138. Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men
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Watts, Eleanor L., Appleby, Paul N., Albanese, Demetrius, Black, Amanda, Chan, June M., Chen, Chu, Cirillo, Piera M., Cohn, Barbara A., Cook, Michael B., Donovan, Jenny L., Ferrucci, Luigi, Garland, Cedric F., Giles, Graham G., Goodman, Phyllis J., Habel, Laurel A., Haiman, Christopher A., Holly, Jeff M. P., Hoover, Robert N., Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N., Kubo, Tatsuhiko, Le Marchand, Loic, Luostarinen, Tapio, Maclnnis, Robert J., Maenpaa, Hanna O., Mannisto, Satu, Metter, E. Jeffrey, Milne, Roger L., Nomura, Abraham M. Y., Oliver, Steven E., Parsons, J. Kellogg, Peeters, Petra H., Platz, Elizabeth A., Riboli, Elio, Ricceri, Fulvio, Rinaldi, Sabina, Rissanen, Harri, Sawada, Norie, Schaefer, Catherine A., Schenk, Jeannette M., Stanczyk, Frank Z., Stampfer, Meir, Stattin, Pär, Stenman, Ulf-Hakan, Tjonneland, Anne, Trichopoulou, Antonia, Thompson, Ian M., Tsugane, Shoichiro, Vatten, Lars, Whittemore, Alice S., Ziegler, Regina G., Allen, Naomi E., Key, Timothy J., Travis, Ruth C., Watts, Eleanor L., Appleby, Paul N., Albanese, Demetrius, Black, Amanda, Chan, June M., Chen, Chu, Cirillo, Piera M., Cohn, Barbara A., Cook, Michael B., Donovan, Jenny L., Ferrucci, Luigi, Garland, Cedric F., Giles, Graham G., Goodman, Phyllis J., Habel, Laurel A., Haiman, Christopher A., Holly, Jeff M. P., Hoover, Robert N., Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N., Kubo, Tatsuhiko, Le Marchand, Loic, Luostarinen, Tapio, Maclnnis, Robert J., Maenpaa, Hanna O., Mannisto, Satu, Metter, E. Jeffrey, Milne, Roger L., Nomura, Abraham M. Y., Oliver, Steven E., Parsons, J. Kellogg, Peeters, Petra H., Platz, Elizabeth A., Riboli, Elio, Ricceri, Fulvio, Rinaldi, Sabina, Rissanen, Harri, Sawada, Norie, Schaefer, Catherine A., Schenk, Jeannette M., Stanczyk, Frank Z., Stampfer, Meir, Stattin, Pär, Stenman, Ulf-Hakan, Tjonneland, Anne, Trichopoulou, Antonia, Thompson, Ian M., Tsugane, Shoichiro, Vatten, Lars, Whittemore, Alice S., Ziegler, Regina G., Allen, Naomi E., Key, Timothy J., and Travis, Ruth C.
- Abstract
Introduction: Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin. Methods: Statistical analyses of individual participant data from 12,330 male controls aged 25–85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates. Results: Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones. Conclusion: Circulating sex hormones in men are strongly associated
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- 2017
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139. Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men
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Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Watts, Eleanor L, Appleby, Paul N., Albanes, Demetrius, Black, Amanda, Chan, June M, Chen, Chu, Cirillo, Piera M, Cohn, Barbara A, Cook, Michael B, Donovan, Jenny L., Ferrucci, Luigi, Garland, Cedric F, Giles, Graham G., Goodman, Phyllis J, Habel, Laurel A, Haiman, Christopher A., Holly, Jeff M P, Hoover, Robert N., Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N, Kubo, Tatsuhiko, Le Marchand, Loïc, Luostarinen, Tapio, MacInnis, Robert J, Mäenpää, Hanna O, Männistö, Satu, Metter, E Jeffrey, Milne, Roger L., Nomura, Abraham M Y, Oliver, Steven E, Parsons, J Kellogg, Peeters, Petra H, Platz, Elizabeth A, Riboli, Elio, Ricceri, Fulvio, Rinaldi, Sabina, Rissanen, Harri, Sawada, Norie, Schaefer, Catherine A, Schenk, Jeannette M, Stanczyk, Frank Z, Stampfer, Meir, Stattin, Pär, Stenman, Ulf-Håkan, Tjønneland, Anne, Trichopoulou, Antonia, Thompson, Ian M, Tsugane, Shoichiro, Vatten, Lars, Whittemore, Alice S., Ziegler, Regina G., Allen, Naomi E., Key, Timothy J., Travis, Ruth C., Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Watts, Eleanor L, Appleby, Paul N., Albanes, Demetrius, Black, Amanda, Chan, June M, Chen, Chu, Cirillo, Piera M, Cohn, Barbara A, Cook, Michael B, Donovan, Jenny L., Ferrucci, Luigi, Garland, Cedric F, Giles, Graham G., Goodman, Phyllis J, Habel, Laurel A, Haiman, Christopher A., Holly, Jeff M P, Hoover, Robert N., Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N, Kubo, Tatsuhiko, Le Marchand, Loïc, Luostarinen, Tapio, MacInnis, Robert J, Mäenpää, Hanna O, Männistö, Satu, Metter, E Jeffrey, Milne, Roger L., Nomura, Abraham M Y, Oliver, Steven E, Parsons, J Kellogg, Peeters, Petra H, Platz, Elizabeth A, Riboli, Elio, Ricceri, Fulvio, Rinaldi, Sabina, Rissanen, Harri, Sawada, Norie, Schaefer, Catherine A, Schenk, Jeannette M, Stanczyk, Frank Z, Stampfer, Meir, Stattin, Pär, Stenman, Ulf-Håkan, Tjønneland, Anne, Trichopoulou, Antonia, Thompson, Ian M, Tsugane, Shoichiro, Vatten, Lars, Whittemore, Alice S., Ziegler, Regina G., Allen, Naomi E., Key, Timothy J., and Travis, Ruth C.
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- 2017
140. A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk
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Travis, Ruth, Appleby, Paul, Martin, Richard, Holly, Jeff M.P., Albanes, Demetrius, Black, Amanda, Bueno-De-Mesquita, H. Bas, Chan, June, Chen, Chu, Chirlaque, María-Dolores, Cook, Michael, Deschasaux, Mélanie, Donovan, Jenny, Ferrucci, Luigi, Galan, Pilar, Giles, Graham, Giovannucci, Edward, Gunter, Marc, Habel, Laurel, Hamdy, Freddie, Helzlsouer, Kathy, Hercberg, Serge, Hoover, Robert, Janssen, Joseph A.M.J.L., Kaaks, Rudolf, Kubo, Tatsuhiko, Le Marchand, Loïc, Metter, E. Jeffrey, Mikami, Kazuya, Morris, Joan, Neal, David, Neuhouser, Marian, Ozasa, Kotaro, Palli, Domenico, Platz, Elizabeth, Pollak, Michael, Price, Alison, Roobol, Monique, Schaefer, Catherine, Schenk, Jeannette, Severi, Gianluca, Stampfer, Meir, Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine, Touvier, Mathilde, Wald, Nicholas, Weiss, Noel, Ziegler, Regina, Key, Timothy, Allen, Naomi, Nuffield Department of Population Health [Oxford], University of Oxford [Oxford], School of Social and Community Medicine [Bristol], University of Bristol [Bristol], National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), National Institute for Public Health and the Environment [Bilthoven] (RIVM), University of California [San Francisco] (UCSF), University of California, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública (CIBERESP), Los Centros de Investigación Biomédica en Red (CIBER), Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Institute on Aging [Bethesda, USA] (NIA), University of Melbourne, Harvard School of Public Health, School of Public Health - Department of Epidemiology and Biostatistics, Imperial College London, Kaiser Permanente, Nuffield (Nuffield), Mercy Medical Center, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University of Occupational and Environmental Health [Kitakyushu] (UEOH), University of Hawai‘i [Mānoa] (UHM), Kyoto Prefectural University of Medicine [Kyoto, Japon], Queen Mary University of London (QMUL), University of Cambridge [UK] (CAM), Radiation Effects Research Foundation, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Cancer Prevention Research Unit, Department of Oncology, McGill University = Université McGill [Montréal, Canada]-Jewish General Hospital, University of Washington [Seattle], Cancer Epidemiology Centre, Cancer Council Victoria, Human Genetics Foundation (HuGeF), Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Hokkaido University Hospital [Sapporo], University of Oxford, University of California [San Francisco] (UC San Francisco), University of California (UC), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), and Deschasaux-Tanguy, Mélanie
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Urologic Diseases ,Male ,Aging ,Oncology and Carcinogenesis ,Article ,growth-factor-i ,serum-insulin ,Risk Factors ,prevention trial ,Humans ,Oncology & Carcinogenesis ,Insulin-Like Growth Factor I ,factor axis ,igfbp-3 ,Cancer ,Aged ,Prostate Cancer ,hyperplasia ,Prostatic Neoplasms ,Middle Aged ,susceptibility loci ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,factor-binding protein-2 ,Centre for Surgical Research ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,factor (igf)-i ,diet ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. Aftermutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.
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- 2016
141. Health-related quality of life in active duty military: A secondary data analysis of two randomized controlled trials
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Talbot, Laura A., primary, Brede, Emily, additional, Price, Marquita, additional, and Metter, E. Jeffrey, additional
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- 2017
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142. Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans
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Lustig, Ana, primary, Liu, Hans B., additional, Metter, E. Jeffrey, additional, An, Yang, additional, Swaby, Melissa A., additional, Elango, Palchamy, additional, Ferrucci, Luigi, additional, Hodes, Richard J., additional, and Weng, Nan-ping, additional
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- 2017
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143. Psychological and Physical Health in Military Amputees During Rehabilitation: Secondary Analysis of a Randomized Controlled Trial
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Talbot, Laura A., primary, Brede, Emily, additional, and Metter, E. Jeffrey, additional
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- 2017
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144. Effects of Adding Neuromuscular Electrical Stimulation to Traditional Military Amputee Rehabilitation
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Talbot, Laura A., primary, Brede, Emily, additional, and Metter, E. Jeffrey, additional
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- 2017
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145. Predictors for Tracheostomy with External Validation of the Stroke-Related Early Tracheostomy Score (SETscore).
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Alsherbini, Khalid, Goyal, Nitin, Metter, E. Jeffrey, Pandhi, Abhi, Tsivgoulis, Georgios, Huffstatler, Tracy, Kelly, Hallie, Elijovich, Lucas, Malkoff, Marc, and Alexandrov, Andrei
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INTENSIVE care patients ,TRACHEOTOMY ,SUBARACHNOID hemorrhage ,LOGISTIC regression analysis - Abstract
Background and Purpose: Ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) patients often require endotracheal intubation (EI) and mechanical ventilation (MV). Predicting the need for prolonged EI and timing of tracheostomy (TR) is challenging. While TR is performed for about 10-15% of patients in the general intensive care unit (ICU), the rate in the neurological ICU and for stroke patients ranges between 15 and 35%. Thus, we performed an external validation of the recently published SETscore.Methods: This is a retrospective review for all patients with IS, non-traumatic ICH, and SAH who required intubation within 48 h of admission to the neurological ICU. We compared the SETscore between tracheostomized versus successfully extubated patients, and early TR (within 7 days) versus late TR (after 7 days).Results: Out of 511 intubated patients, 140 tracheostomized and 105 extubated were included. The sensitivity for a SETscore > 10 to predict the need for TR was 81% (95% CI 74-87%) with a specificity of 57% (95% CI 48-67%). The score had moderate accuracy in correctly identifying those requiring TR and those successfully extubated: 71% (95% CI 65-76%). The AUC of the score was 0.74 (95% CI 0.68-0.81). Multivariable logistic regression models were used to identify other independent predictors of TR. After including body mass index (BMI), African American (AA) race, ICH and a positive sputum culture in the SETscore, sensitivity, specificity, overall accuracy, and AUC improved to 90%, 78%, 85%, and 0.89 (95% CI 0.85-0.93), respectively. In our cohort, performing early TR was associated with improvement in the ICU median length of stay (LOS) (15 vs 20.5 days; p = 0.002) and mean ventilator duration (VD) (13.4 vs 18.2 days; p = 0.005) in comparison to late TR.Conclusions: SETscore is a simple score with a moderate accuracy and with a fair AUC used to predict the need for TR after MV for IS, ICH, and SAH patients. Our study also demonstrates that early TR was associated with a lower ICU LOS and VD in our cohort. The utility of this score may be improved when including additional variables such as BMI, AA race, ICH, and positive sputum cultures. [ABSTRACT FROM AUTHOR]- Published
- 2019
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146. Selenium and Prostate Cancer : Analysis of Individual Participant Data From Fifteen Prospective Studies.
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Allen, Naomi E, Travis, Ruth C, Appleby, Paul N, Albanes, Demetrius, Barnett, Matt J, Black, Amanda, Bueno-de-Mesquita, H Bas, Deschasaux, Mélanie, Galan, Pilar, Goodman, Gary E, Goodman, Phyllis J, Gunter, Marc J, Heliövaara, Markku, Helzlsouer, Kathy J, Henderson, Brian E, Hercberg, Serge, Knekt, Paul, Kolonel, Laurence N, Lasheras, Christina, Linseisen, Jakob, Metter, E Jeffrey, Neuhouser, Marian L, Olsen, Anja, Pala, Valeria, Platz, Elizabeth A, Rissanen, Harri, Reid, Mary E, Schenk, Jeannette M, Stampfer, Meir J, Stattin, Pär, Tangen, Catherine M, Touvier, Mathilde, Trichopoulou, Antonia, van den Brandt, Piet A, Key, Timothy J, Allen, Naomi E, Travis, Ruth C, Appleby, Paul N, Albanes, Demetrius, Barnett, Matt J, Black, Amanda, Bueno-de-Mesquita, H Bas, Deschasaux, Mélanie, Galan, Pilar, Goodman, Gary E, Goodman, Phyllis J, Gunter, Marc J, Heliövaara, Markku, Helzlsouer, Kathy J, Henderson, Brian E, Hercberg, Serge, Knekt, Paul, Kolonel, Laurence N, Lasheras, Christina, Linseisen, Jakob, Metter, E Jeffrey, Neuhouser, Marian L, Olsen, Anja, Pala, Valeria, Platz, Elizabeth A, Rissanen, Harri, Reid, Mary E, Schenk, Jeannette M, Stampfer, Meir J, Stattin, Pär, Tangen, Catherine M, Touvier, Mathilde, Trichopoulou, Antonia, van den Brandt, Piet A, and Key, Timothy J
- Abstract
BACKGROUND: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade. METHODS: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on blood or toenail selenium concentrations and prostate cancer risk. Odds ratios of prostate cancer by selenium concentration were estimated using multivariable-adjusted conditional logistic regression. All statistical tests were two-sided. RESULTS: Blood selenium was not associated with the risk of total prostate cancer (multivariable-adjusted odds ratio [OR] per 80 percentile increase = 1.01, 95% confidence interval [CI] = 0.83 to 1.23, based on 4527 case patients and 6021 control subjects). However, there was heterogeneity by disease aggressiveness (ie, advanced stage and/or prostate cancer death, Pheterogeneity = .01), with high blood selenium associated with a lower risk of aggressive disease (OR = 0.43, 95% CI = 0.21 to 0.87) but not with nonaggressive disease. Nail selenium was inversely associated with total prostate cancer (OR = 0.29, 95% CI = 0.22 to 0.40, Ptrend < .001, based on 1970 case patients and 2086 control subjects), including both nonaggressive (OR = 0.33, 95% CI = 0.22 to 0.50) and aggressive disease (OR = 0.18, 95% CI = 0.11 to 0.31, Pheterogeneity = .08). CONCLUSIONS: Nail, but not blood, selenium concentration is inversely associated with risk of total prostate cancer, possibly because nails are a more reliable marker of long-term selenium exposure. Both blood and nail selenium concentrations are associated with a reduced risk of aggressive disease, which warrants further investigation.
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- 2016
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147. A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
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Travis, Ruth C., Appleby, Paul N., Martin, Richard M., Holly, Jeff M. P., Albanes, Demetrius, Black, Amanda, Bueno-de-Mesquita, H. Bas, Chan, June M., Chen, Chu, Chirlaque, Maria-Dolores, Cook, Michael B., Deschasaux, Melanie, Donovan, Jenny L., Ferrucci, Luigi, Galan, Pilar, Giles, Graham G., Giovannucci, Edward L., Gunter, Marc J., Habel, Laurel A., Hamdy, Freddie C., Helzlsouer, Kathy J., Hercberg, Serge, Hoover, Robert N., Janssen, Joseph A. M. J. L., Kaaks, Rudolf, Kubo, Tatsuhiko, Le Marchand, Loic, Metter, E. Jeffrey, Mikami, Kazuya, Morris, Joan K., Neal, David E., Neuhouser, Marian L., Ozasa, Kotaro, Palli, Domenico, Platz, Elizabeth A., Pollak, Michael N., Price, Alison J., Roobol, Monique J., Schaefer, Catherine, Schenk, Jeannette M., Severi, Gianluca, Stampfer, Meir J., Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M., Touvier, Mathilde, Wald, Nicholas J., Weiss, Noel S., Ziegler, Regina G., Key, Timothy J., Allen, Naomi E., Travis, Ruth C., Appleby, Paul N., Martin, Richard M., Holly, Jeff M. P., Albanes, Demetrius, Black, Amanda, Bueno-de-Mesquita, H. Bas, Chan, June M., Chen, Chu, Chirlaque, Maria-Dolores, Cook, Michael B., Deschasaux, Melanie, Donovan, Jenny L., Ferrucci, Luigi, Galan, Pilar, Giles, Graham G., Giovannucci, Edward L., Gunter, Marc J., Habel, Laurel A., Hamdy, Freddie C., Helzlsouer, Kathy J., Hercberg, Serge, Hoover, Robert N., Janssen, Joseph A. M. J. L., Kaaks, Rudolf, Kubo, Tatsuhiko, Le Marchand, Loic, Metter, E. Jeffrey, Mikami, Kazuya, Morris, Joan K., Neal, David E., Neuhouser, Marian L., Ozasa, Kotaro, Palli, Domenico, Platz, Elizabeth A., Pollak, Michael N., Price, Alison J., Roobol, Monique J., Schaefer, Catherine, Schenk, Jeannette M., Severi, Gianluca, Stampfer, Meir J., Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M., Touvier, Mathilde, Wald, Nicholas J., Weiss, Noel S., Ziegler, Regina G., Key, Timothy J., and Allen, Naomi E.
- Abstract
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (P-trend all <= 0.005), and IGFBP-1 was inversely associated weakly with risk (P-trend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (P-heterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, P-heterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.
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- 2016
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148. A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.
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Travis, Ruth C, Travis, Ruth C, Appleby, Paul N, Martin, Richard M, Holly, Jeff MP, Albanes, Demetrius, Black, Amanda, Bueno-de-Mesquita, HB As, Chan, June M, Chen, Chu, Chirlaque, Maria-Dolores, Cook, Michael B, Deschasaux, Mélanie, Donovan, Jenny L, Ferrucci, Luigi, Galan, Pilar, Giles, Graham G, Giovannucci, Edward L, Gunter, Marc J, Habel, Laurel A, Hamdy, Freddie C, Helzlsouer, Kathy J, Hercberg, Serge, Hoover, Robert N, Janssen, Joseph AMJL, Kaaks, Rudolf, Kubo, Tatsuhiko, Le Marchand, Loic, Metter, E Jeffrey, Mikami, Kazuya, Morris, Joan K, Neal, David E, Neuhouser, Marian L, Ozasa, Kotaro, Palli, Domenico, Platz, Elizabeth A, Pollak, Michael, Price, Alison J, Roobol, Monique J, Schaefer, Catherine, Schenk, Jeannette M, Severi, Gianluca, Stampfer, Meir J, Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M, Touvier, Mathilde, Wald, Nicholas J, Weiss, Noel S, Ziegler, Regina G, Key, Timothy J, Allen, Naomi E, Travis, Ruth C, Travis, Ruth C, Appleby, Paul N, Martin, Richard M, Holly, Jeff MP, Albanes, Demetrius, Black, Amanda, Bueno-de-Mesquita, HB As, Chan, June M, Chen, Chu, Chirlaque, Maria-Dolores, Cook, Michael B, Deschasaux, Mélanie, Donovan, Jenny L, Ferrucci, Luigi, Galan, Pilar, Giles, Graham G, Giovannucci, Edward L, Gunter, Marc J, Habel, Laurel A, Hamdy, Freddie C, Helzlsouer, Kathy J, Hercberg, Serge, Hoover, Robert N, Janssen, Joseph AMJL, Kaaks, Rudolf, Kubo, Tatsuhiko, Le Marchand, Loic, Metter, E Jeffrey, Mikami, Kazuya, Morris, Joan K, Neal, David E, Neuhouser, Marian L, Ozasa, Kotaro, Palli, Domenico, Platz, Elizabeth A, Pollak, Michael, Price, Alison J, Roobol, Monique J, Schaefer, Catherine, Schenk, Jeannette M, Severi, Gianluca, Stampfer, Meir J, Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M, Touvier, Mathilde, Wald, Nicholas J, Weiss, Noel S, Ziegler, Regina G, Key, Timothy J, and Allen, Naomi E
- Abstract
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.
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- 2016
149. Relationship Between Muscle Strength and the Time Taken to Complete a Standardized Walk-Turn-Walk Test
- Author
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Kwon, In Soon, Oldaker, Sandra, Schrager, Matthew, Talbot, Laura A., Fozard, James L., and Metter, E. Jeffrey
- Subjects
Gerontology -- Research ,Aging -- Physiological aspects ,Muscle strength -- Testing ,Frail elderly -- Demographic aspects ,Health ,Seniors - Abstract
We examined the effects of age and gender on the relationship between knee strength and walking time during a walk-turn-walk test in 176 male and 168 female generally healthy participants of the Baltimore Longitudinal Study of Aging who were aged 21-89 years. Subjects were timed as they walked 50 ft (15.24 m), turned around, and walked back to the starting point, both at a comfortable pace and as fast as possible. Isokinetic concentric knee extensor strength was measured at 30[degrees]/s by using a Kin-Com dynamometer. Both comfortable and fast gait times increased with increasing age for both women and men, starting in middle age. An interaction was found between gender and age showing that older women are slower than older men at both paces. Gait time decreased linearly with increasing knee extensor strength, plateauing at higher strength levels ([is greater than] 130 N m for comfortable gait, and 190 N m for fast gait). Most women occupied the linear part of the curve below the plateau. Adjustment for body size, age, physical activity, and particularly number of steps to complete the task removed the relationship between strength and gait time for the comfortable gait. Women took longer to complete the walk-turn-walk test than men at older ages, were on the linear part of the strength--gait time relationship, and used more steps to complete the task, all of which may contribute to their greater likelihood of frailty in later years.
- Published
- 2001
150. Effects of Age, Gender, and Myostatin Genotype on the Hypertrophic Response to Heavy Resistance Strength Training
- Author
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Ivey, Frederick M., Roth, Stephen M., Ferrell, Robert E., Tracy, Brian L., Lemmer, Jeffrey T., Hurlbut, Diane E., Martel, Gregory F., Siegel, Eliot L., Fozard, James L., Metter, E. Jeffrey, Fleg, Jerome L., and Hurley, Ben F.
- Subjects
Physical fitness for the aged -- Research ,Muscle strength -- Research ,Aged -- Health aspects ,Women's fitness -- Research ,Physical fitness -- Research ,Health ,Seniors - Abstract
Background. Because of the scarcity of data available from direct comparisons of age and gender groups using the same relative training stimulus, it is unknown whether older individuals can increase their muscle mass as much as young individuals and whether women can increase as much as men in response to strength training (ST). In addition, little is known about whether the hypertrophic response to ST is affected by myostatin genotype, a candidate gene for muscle hypertrophy. Methods. Eleven young men (25 [+ or -] 3 years, range 21-29 years), 11 young women (26 [+ or -] 2 years, range 23-28 years), 12 older men (69 [+ or -] 3 years, range 65-75 years), and 11 older women (68 [+ or -] 2 years, range 65-73 years) had bilateral quadriceps muscle volume measurements performed using magnetic resonance imaging (MRI) before and after ST and detraining. Training consisted of knee extension exercises of the dominant leg three times per week for 9 weeks. The contralateral limb was left untrained throughout the ST program. Following the unilateral training period, the subjects underwent 31 weeks of detraining during which no regular exercise was performed. Myostatin genotype was determined in a subgroup of 32 subjects, of which five female subjects were carriers of a myostatin gene variant. Results. A significantly greater absolute increase in muscle volume was observed in men than in women (204 [+ or -] 20 vs 101 [+ or -] 13 [cm.sup.3], p [is less than].01), but there was no significant difference in muscle volume response to ST between young and older individuals. The gender effect remained after adjusting for baseline muscle volume. In addition, there was a significantly greater loss of absolute muscle volume after 31 weeks of detraining in men than in women (151 [+ or -] 13 vs 88 [+ or -] 7 [cm.sup.3], p [is less than] .05), but no significant difference between young and older individuals. Myostatin genotype did not explain the hypertrophic response to ST when all 32 subjects were assessed. However, when only women were analyzed, those with the less common myostatin allele exhibited a 68% larger increase in muscle volume in response to ST (p = .056). Conclusions. Aging does not affect the muscle mass response to either ST or detraining, whereas gender does, as men increased their muscle volume about twice as much in response to ST as did women and experienced larger losses in response to detraining than women. Young men were the only group that maintained muscle volume adaptation after 31 weeks of detraining. Although myostatin genotype may not explain the observed gender difference in the hypertrophic response to ST, a role for myostatin genotype may be indicated in this regard for women, but future studies are needed with larger subject numbers in each genotype group to confirm this observation.
- Published
- 2000
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