101. [Plasma kinin system indices in diabetes mellitus patients before and after treatment with prodectin].
- Author
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Spesivtseva VG, Men'shikov VV, Beliakov NV, Mamaeva GG, and Stepanova NI
- Subjects
- Adolescent, Adult, Aged, Diabetes Mellitus blood, Diabetic Angiopathies drug therapy, Humans, Kallikreins blood, Kininogens blood, Lysine Carboxypeptidase blood, Middle Aged, Carbamates therapeutic use, Diabetes Mellitus drug therapy, Hypoglycemic Agents, Kinins blood, Pyridinolcarbamate therapeutic use
- Abstract
Kinin system was investigated in 82 patients suffering from diabetes mellitus of various severity. To make pathogenetically substantiated pharmacological correction of the kinin system activity prodectin--kinin antagonist--was used in these patients. A conclusion was drawn that the blood plasma kinin system was activated in the patients with moderately severe and severe diabetes. The activity of total kallikrein and kininogen became normal against the background of prodectin treatment. The blood plasma kinin system activity was normalized simultaneously with the improvement of the diabetic angiopathies course.
- Published
- 1978