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102. Tumors of the Skull Base

Author

Schick, Uta, primary, Borghei-Razavi, Hamid, additional, Fugleholm, Kåre, additional, Troude, Lucas, additional, Soumare, Outouma, additional, Melot, Anthony, additional, Roche, Pierre-Hugues, additional, Meling, Torstein R., additional, Inoue, Goh, additional, Fukushima, Takanori, additional, Nonaka, Yoichi, additional, Barkas, Konstantinos, additional, Barazi, Sinan, additional, Thomas, Nick, additional, König, Alexander, additional, Ranguis, Sebastian, additional, and Spetzger, Uwe, additional

Published
2017
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104. The Aftercare Survey: Assessment and intervention practices after brain tumor surgery in Europe

Author

Sierpowska, Joanna, primary, Rofes, Adrià, additional, Dahlslätt, Kristoffer, additional, Mandonnet, Emmanuel, additional, ter Laan, Mark, additional, Połczyńska, Monika, additional, Hamer, Philip De Witt, additional, Halaj, Matej, additional, Spena, Giannantonio, additional, Meling, Torstein R, additional, Motomura, Kazuya, additional, Reyes, Andrés Felipe, additional, Campos, Alexandre Rainha, additional, Robe, Pierre A, additional, Zigiotto, Luca, additional, Sarubbo, Silvio, additional, Freyschlag, Christian F, additional, Broen, Martijn P G, additional, Stranjalis, George, additional, Papadopoulos, Konstantinos, additional, Liouta, Evangelia, additional, Rutten, Geert-Jan, additional, Viegas, Catarina Pessanha, additional, Silvestre, Ana, additional, Perrote, Federico, additional, Brochero, Natacha, additional, Cáceres, Cynthia, additional, Zdun-Ryżewska, Agata, additional, Kloc, Wojciech, additional, Satoer, Djaina, additional, Dragoy, Olga, additional, Hendriks, Marc P H, additional, Alvarez-Carriles, Juan C, additional, and Piai, Vitória, additional

Published
2022
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107. Contributors

Author

Araújo, Érica S.S., primary, Bashashati, Mohammad, additional, Bassi, Shivani, additional, Cirino, Giuseppe, additional, Collichio, Frances A., additional, Davies, Michael A., additional, Duchnowska, Renata, additional, Engelman, Alexander, additional, Esmaeilzadeh, Majid, additional, Ewend, Matthew G., additional, Fine, Robert Lance, additional, Fontanella, Caterina, additional, Forsyth, Peter A., additional, Gandhoke, Gurpreet S., additional, Glitza, Isabella C., additional, Gulati, Anthony Paul, additional, Guo, Jun, additional, Hayat, M.A., additional, Heimberger, Amy, additional, Helseth, Eirik, additional, Hong, Angela M., additional, Ianaro, Angela, additional, Jassem, Jacek, additional, Kavecansky, Juraj, additional, Kee, Damien, additional, Keramati, Mohammad Reza, additional, Khoury, Michael N., additional, Krepischi, Ana C.V., additional, Kwok, Young, additional, Lau, Peter, additional, Lal, Supriya, additional, Leclerc, Estelle, additional, Lee, Carrie B., additional, Long, Georgina V., additional, Lunsford, L. Dade, additional, Lyle, Megan, additional, Mao, Lili, additional, Meling, Torstein R., additional, Missios, Symeon, additional, Monaco, Edward A., additional, Moschos, Stergios J., additional, Nichols, Elizabeth, additional, Niranjan, Ajay, additional, Osa, Etin-Osa, additional, Pavlick, Anna C., additional, Pramio, Dimitrius T., additional, Puglisi, Fabio, additional, Rogne, Siril G., additional, Shivalingam, Brindha, additional, Sulman, Erik P., additional, Svokos, Konstantina, additional, Tanaka, Toshihide, additional, Tarhini, Ahmad A., additional, Thompson, John F., additional, Toms, Steven A., additional, Tran, Nam D., additional, Trembath, Dimitri, additional, Weiss, Sarah A., additional, and Zagar, Timothy M., additional

Published
2016
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112. Work Related Musculoskeletal Disorders in Spine Surgeons.

Author

Mavrovounis, Georgios, Meling, Torstein R, Lafuente, Jesus, Fountas, Kostas N, and Demetriades, Andreas K

Subjects
MUSCULOSKELETAL system diseases, NECK pain, SPINE, SURGEONS, SPINAL surgery, ORTHOPEDISTS, SICK leave
Abstract

A study published in the Global Spine Journal examined the prevalence of work-related neck pain in spine surgeons. The study found that 66.3% of the 383 spine surgeons surveyed reported experiencing neck pain at least once in the previous year. Factors associated with neck pain included younger age, lack of participation in sports, and exposure to physical stress. Interestingly, the study also found that surgeons who performed more than 300 operations per year reported fewer work-related musculoskeletal disorders. The authors suggest that further research should focus on real-time measurements of ergonomic parameters during surgery. [Extracted from the article]

Published
2024
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114. Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part III: Lower cranial nerve schwannomas, jugular foramen (CN IX, X, XI) and hypoglossal schwannoma (XII)

Author

Bal, Jarnail, primary, Bruneau, Michael, additional, Berhouma, Moncef, additional, Cornelius, Jan F., additional, Cavallo, Luigi M., additional, Daniel, Roy T., additional, Froelich, Sebastien, additional, Jouanneau, Emmanuel, additional, Meling, Torstein R., additional, Messerer, Mahmoud, additional, Roche, Pierre-Hugues, additional, Schroeder, Henry, additional, Tatagiba, Marcos, additional, Zazpe, Idoya, additional, and Paraskevopoulos, Dimitrios, additional

Published
2021
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116. Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section. Part I: oculomotor and other rare non-vestibular schwannomas (I, II, III, IV, VI)

Author

Bal, Jarnail, primary, Bruneau, Michael, additional, Berhouma, Moncef, additional, Cornelius, Jan F., additional, Cavallo, Luigi M., additional, Daniel, Roy T., additional, Froelich, Sebastien, additional, Jouanneau, Emmanuel, additional, Meling, Torstein R., additional, Messerer, Mahmoud, additional, Roche, Pierre-Hugues, additional, Schroeder, Henry W. S., additional, Tatagiba, Marcos, additional, Zazpe, Idoya, additional, and Paraskevopoulos, Dimitrios, additional

Published
2021
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118. Novel human melanoma brain metastasis models in athymic nude fox1 nu mice: Site‐specific metastasis patterns reflecting their clinical origin

Author

Svendsen, Henrik A., primary, Meling, Torstein R., additional, Nygaard, Vigdis, additional, Waagene, Stein, additional, Russnes, Hege, additional, Juell, Siri, additional, Rogne, Siril G., additional, Pahnke, Jens, additional, Helseth, Eirik, additional, Fodstad, Øystein, additional, and Mælandsmo, Gunhild M., additional

Published
2021
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119. The “STARS–CT-MADE” Study: Advanced Rehearsal and Intraoperative Navigation for Skull Base Tumors

Author

Perin, Alessandro, primary, Carone, Giovanni, additional, Rui, Chiara Bendetta, additional, Raspagliesi, Luca, additional, Fanizzi, Claudia, additional, Galbiati, Tommaso Francesco, additional, Gambatesa, Enrico, additional, Ayadi, Roberta, additional, Casali, Cecilia, additional, Meling, Torstein R., additional, Fontanella, Marco Maria, additional, and DiMeco, Francesco, additional

Published
2021
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127. Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis.

Author

Morel, Sandrine, Hostettler, Isabel C., Spinner, Georg R., Bourcier, Romain, Pera, Joanna, Meling, Torstein R., Alg, Varinder S., Houlden, Henry, Bakker, Mark K., van't Hof, Femke, Rinkel, Gabriel J. E., Foroud, Tatiana, Lai, Dongbing, Moomaw, Charles J., Worrall, Bradford B., Caroff, Jildaz, Constant-dits-Beaufils, Pacôme, Karakachoff, Matilde, Rimbert, Antoine, and Rouchaud, Aymeric

Subjects
INTRACRANIAL aneurysms, SMOKING statistics, SUBARACHNOID hemorrhage, RISK perception, PHENOTYPES, WOMEN patients, OLDER patients
Abstract

Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making. [ABSTRACT FROM AUTHOR]

Published
2022
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128. Aftercare Survey: Assessment and intervention practices after brain tumor surgery in Europe.

Author

Sierpowska, Joanna, Rofes, Adrià, Dahlslätt, Kristoffer, Mandonnet, Emmanuel, Laan, Mark ter, Połczyńska, Monika, Hamer, Philip De Witt, Halaj, Matej, Spena, Giannantonio, Meling, Torstein R, Motomura, Kazuya, Reyes, Andrés Felipe, Campos, Alexandre Rainha, Robe, Pierre A, Zigiotto, Luca, Sarubbo, Silvio, Freyschlag, Christian F, Broen, Martijn P G, Stranjalis, George, and Papadopoulos, Konstantinos

Subjects
TUMOR surgery, BRAIN tumors, PSYCHOLOGICAL tests, PATIENT aftercare, COGNITIVE rehabilitation, BRAIN surgery
Abstract

Background People with gliomas need specialized neurosurgical, neuro-oncological, psycho-oncological, and neuropsychological care. The role of language and cognitive recovery and rehabilitation in patients' well-being and resumption of work is crucial, but there are no clear guidelines for the ideal timing and character of assessments and interventions. The goal of the present work was to describe representative (neuro)psychological practices implemented after brain surgery in Europe. Methods An online survey was addressed to professionals working with individuals after brain surgery. We inquired about the assessments and interventions and the involvement of caregivers. Additionally, we asked about recommendations for an ideal assessment and intervention plan. Results Thirty-eight European centers completed the survey. Thirty of them offered at least one postsurgical (neuro)psychological assessment, mainly for language and cognition, especially during the early recovery stage and at long term. Twenty-eight of the participating centers offered postsurgical therapies. Patients who stand the highest chances of being included in evaluation and therapy postsurgically are those who underwent awake brain surgery, harbored a low-grade glioma, or showed poor recovery. Nearly half of the respondents offer support programs to caregivers, and all teams recommend them. Treatments differed between those offered to individuals with low-grade glioma vs those with high-grade glioma. The figure of caregiver is not yet fully recognized in the recovery phase. Conclusion We stress the need for more complete rehabilitation plans, including the emotional and health-related aspects of recovery. In respondents' opinions, assessment and rehabilitation plans should also be individually tailored and goal-directed (eg, professional reinsertion). [ABSTRACT FROM AUTHOR]

Published
2022
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141. A tumor like no other

Author

Corniola, Marco V., primary, Egervari, Kristof, additional, Vargas, Maria I., additional, and Meling, Torstein R., additional

Published
2021
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146. Robust association between vascular habitats and patient prognosis in glioblastoma: an international retrospective multicenter study

Author

Álvarez-Torres, María del Mar, Juan-Albarracín, Javier, Fuster García, Elíes, Bellvís-Bataller, Fuensanta, Lorente, David, Reynés, Gaspar, Font de Mora, Jaime, Aparici-Robles, Fernando, Botella, Carlos, Muñoz-Langa, Jose, Faubel, Raquel, Asensio-Cuesta, Sabina, García-Ferrando, Germán A., Chelebian, Eduard, Auger, Cristina, Pineda, Jose, Rovira, Alex, Oleaga, Laura, Mollà Olmos, Enrique, Revert, Antonio J., Tshibanda, Luaba, Crisi, Girolamo, Emblem, Kyrre E., Martin, Didier, Due-Tønnessen, Paulina, Meling, Torstein R., Filice, Silvano, Sáez Silvestre, Carlos, and Garcia-Gomez, Juan M

Subjects
Vascularity, FISICA APLICADA, Perfusion DSC, Overall survival, Glioblastoma, PROYECTOS DE INGENIERIA, Multicenter study
Abstract

[EN] Background Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by a heterogeneous and abnormal vascularity. Subtypes of vascular habitats within the tumor and edema can be distinguished: high angiogenic tumor (HAT), low angiogenic tumor (LAT), infiltrated peripheral edema (IPE), and vasogenic peripheral edema (VPE). Purpose To validate the association between hemodynamic markers from vascular habitats and overall survival (OS) in glioblastoma patients, considering the intercenter variability of acquisition protocols. Study Type Multicenter retrospective study. Population In all, 184 glioblastoma patients from seven European centers participating in the NCT03439332 clinical study. Field Strength/Sequence 1.5T (for 54 patients) or 3.0T (for 130 patients). Pregadolinium and postgadolinium-based contrast agent-enhanced T-1-weighted MRI, T-2- and FLAIR T-2-weighted, and dynamic susceptibility contrast (DSC) T-2* perfusion. Assessment We analyzed preoperative MRIs to establish the association between the maximum relative cerebral blood volume (rCBV(max)) at each habitat with OS. Moreover, the stratification capabilities of the markers to divide patients into "vascular" groups were tested. The variability in the markers between individual centers was also assessed. Statistical Tests Uniparametric Cox regression; Kaplan-Meier test; Mann-Whitney test. Results The rCBV(max) derived from the HAT, LAT, and IPE habitats were significantly associated with patient OS (P < 0.05; hazard ratio [HR]: 1.05, 1.11, 1.28, respectively). Moreover, these markers can stratify patients into "moderate-" and "high-vascular" groups (P < 0.05). The Mann-Whitney test did not find significant differences among most of the centers in markers (HAT: P = 0.02-0.685; LAT: P = 0.010-0.769; IPE: P = 0.093-0.939; VPE: P = 0.016-1.000). Data Conclusion The rCBV(max) calculated in HAT, LAT, and IPE habitats have been validated as clinically relevant prognostic biomarkers for glioblastoma patients in the pretreatment stage. This study demonstrates the robustness of the hemodynamic tissue signature (HTS) habitats to assess the GBM vascular heterogeneity and their association with patient prognosis independently of intercenter variability. Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019., This work was partially supported by: MTS4up project (National Plan for Scientific and Technical Research and Innovation 2013-2016, No. DPI2016-80054-R) (to J.M.G.G.); H2020-SC1-2016-CNECT Project (No. 727560) (to J.M.G.G.) and H2020-SC1-BHC-2018-2020 (No. 825750) (to J.M.G.G.); M.A.T was supported by DPI2016-80054-R (Programa Estatal de Promocion del Talento y su Empleabilidad en I + D + i). The data acquisition and curation of the Oslo University Hospital was supported by: the European Research Council (ERC) under the European Union's Horizon 2020 (Grant Agreement No. 758657), the South-Eastern Norway Regional Health Authority Grants 2017073 and 2013069, and the Research Council of Norway Grants 261984 (to K.E.E.). We gratefully acknowledge the support of NVIDIA Corporation with the donation of the Titan V GPU used for this research. E.F.G. was supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 844646. Figure 1 was designed by the Science Artist Elena Poritskaya.

Published
2020

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