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101. Religiosidade e estilo de vida de uma população adulta

Author: Rosangela Cres, Marli, primary, Andrade Abdala, Gina, additional, Dias Meira, Maria Dyrce, additional, Teixeira, Carlos Antonio, additional, Melo Lopes Ninahuaman, Maria Fernanda, additional, and Leite de Moraes, Maria Cecília, additional
Published: 2015
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102. Perfil do estilo de vida de adultos da zona sul de São Paulo

Author: Meira, Maria Dyrce Dias, primary, Abdala, Gina Andrade, additional, Teixeira, Carlos Antonio, additional, Ninahuaman, Maria Fernanda M. L., additional, Moraes, Maria Cecília Leite de, additional, and Salgueiro, Marcia Maria Hernandes de Abreu de Oliveira, additional
Published: 2015
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103. Perfil nutricional de adultos atendidos em uma feira de saúde em shopping na cidade de São Paulo

Author: Kerolly Beck, Samanta, Hernandes Abreu Oliveira Salgueiro, Marcia Maria, Dias Meira, Maria Dyrce, Bortolli, Letícia Graziela, Lima Silva, Rebeca, Kerolly Beck, Samanta, Hernandes Abreu Oliveira Salgueiro, Marcia Maria, Dias Meira, Maria Dyrce, Bortolli, Letícia Graziela, and Lima Silva, Rebeca
Abstract: Objetivo: Caracterizar o perfil nutricional de adultos atendidos em uma Feira de Saúde em um shopping de São Paulo.Métodos: Estudo transversal descritivo. Foram levantadas informações sociodemográficas (idade, gênero, estado civil, escolaridade, cor da pele), de saúde e de estilo de vida, esta última foi avaliada pelo questionário “Estilo de Vida Fantástico”. As variáveis relacionadas à saúde foi pressão arterial. No questionário o domínio nutrição compreende 3 questões que avaliam se o indivíduo consome uma dieta balanceada, com que frequência ingere em excesso açúcar, sal, gordura animal, bobagens e salgadinhos e o quanto de peso em kg ele está acima do seu peso saudável.Resultados: A população estudada compreendeu 76 indivíduos com média de idade de 36,15 anos + 11,2, sendo 22 homens e 54 mulheres. Quanto ao estado civil, 48,69% eram casados, 75% apresentaram escolaridade maior que 8 anos e 40,79% referiram cor branca. Verificou-se que 22% apresentavam pressão arterial elevada. Quanto ao IMC, 57,90% apresentaram sobrepeso. Em relação à primeira questão do questionário, 55,88% responderam comer uma dieta balanceada algumas vezes. Na segunda questão, 54,2% consumiam em excesso dois itens alimentares. Na terceira questão, 76,42% estavam mais de 8 kg acima do peso considerado saudável.Conclusão: Houve predominância de adultos jovens, feminino, casados, com escolaridade maior que 8 anos e cor branca. 75% estavam em sobrepeso e obesidade, e a maioria consumia uma dieta balanceada somente algumas vezes.
Published: 2014

104. La enseñanza de la administración en el pregrado: la percepción de los enfermeros egresados

Author: Meira, Maria Dyrce Dias and Kurcgant, Paulina
Subjects: Professional competence, Enfermagem, Currículo, Enfermería, Nursing, Curriculum, Competências profissionais, Administración, Competencias profesionales, Administração, Management
Abstract: Os paradigmas ideológicos de uma formação integral; a qualidade do profissional que se pretende formar; o compromisso ético, político e técnico, e a complexidade dos processos de trabalho em enfermagem, levam os cursos a repensarem o ensino e sua adequação às Diretrizes Curriculares Nacionais. Esta pesquisa teve como objetivo identificar nos discursos de 32 egressos a importância atribuída ao ensino de administração durante a graduação e correlacioná-los aos pressupostos das diretrizes. Trata-se de um estudo de caso de abordagem qualitativa. Os dados foram coletados através de entrevista semiestruturada e submetidos à Análise de Conteúdo. Segundo os egressos, o ensino de administração deve ter uma carga horária maior; conteúdos mais abrangentes; estratégias diversificadas; reforçar o desenvolvimento de competências, principalmente as ético-políticas e considerar a unicidade entre ensino, pesquisa e extensão. Segundo os egressos as competências gerenciais merecem destaque na reestruturação do currículo de Enfermagem. The ideological paradigms of a complete nursing background; the professional quality one intends to prepare; the ethical, political, and technical commitment, and the complexity of the nursing work processes cause programs to rethink their teaching and adaptation to Brazilian National Curriculum Guidelines. The objective of this study was to identify in interview conversations with 32 undergraduate nursing students the importance attributed to management classes in their professional preparation and to correlate them to the guidelines' governing principles. This is a qualitative research developed as a case study. The data were collected through semi-structured interviews and submitted to Content Analysis. According to undergraduates, teaching administration must have a greater time load; more encompassing content; diversified strategies; reinforcement of skill development, especially ethical-political skills; and consideration of the union which exists between teaching, research, and community clinical work. According to undergraduates managerial skills deserve special attention in restructuring the nursing curriculum. Los paradigmas ideológicos de una formación integral; el tipo de profesional que se desee formar; el compromiso ético, político, técnico y la complejidad de los procesos de trabajo en enfermería llevan a los cursos a reflexionar sobre la enseñanza y adaptación a las Directrices Curriculares Nacionales. Esta investigación tuvo como objetivo identificar en los discursos de treinta y dos egresados la contribución de la enseñanza de la administración en la formación y relacionarlas a los presupuestos de las directrices. Es una investigación cualitativa desarrollada como Estudio de Caso. Los datos fueron recolectados a través de entrevista semiestructurada, y se examinaron a través del Análisis de Contenido. Según los egresados, la enseñanza de la administración debe tener una mayor carga horaria, contenidos más amplios, diversas estrategias; reforzar el desarrollo de competencias, principalmente ético-políticas y considerar la unificación entre enseñanza, investigación y extensión. Los egresados defienden que las competencias gerenciales merecen destaque en la restructuración del curriculum de enfermería.
Published: 2009

105. Evaluación del Curso de Graduación según los egresados

Author: Meira, Maria Dyrce Dias and Kurcgant, Paulina
Subjects: Evaluación, Estudantes de enfermagem, Educación en enfermería, Estudiantes de enfermería, Educação em enfermagem, Students, Evaluation, Avaliação, Education
Abstract: O egresso da graduação enfrenta, no seu cotidiano, situações complexas que o levam a confrontar as competências desenvolvidas durante o curso com as requeridas no exercício profissional. Tal vivência permite-lhe avaliar a adequação da estrutura pedagógica do curso e resgatar aspectos intervenientes desse processo. Este texto aborda a Avaliação de Cursos de Graduação, resgatando conceitos no campo da Avaliação Educacional; descreve as práticas desenvolvidas no Brasil dirigidas à Avaliação Institucional no âmbito da graduação e apresenta pesquisas relativas à avaliação de cursos, tendo a perspectiva do egresso como indicador. Foram utilizadas as seguintes palavras-chave: egressos, indicadores, avaliação e graduação, disponíveis nas bases de dados: PeriEnf, BDEnf, LILACS e no banco de dados DEDALUS. A análise das pesquisas encontradas ressalta a importância de se considerar a opinião dos egressos na adequação de propostas curriculares com vistas à concretização de um processo educacional com características emancipatórias e transformadoras. Every day, college graduates face complex situations that make them check skills developed during the course in comparison with the skills needed at the professional level. This experience helps them evaluate the adequacy of the course's teaching structure and recover intervening aspects of this process. This text discusses the Evaluation of College Courses, recovering concepts in the field of Education Evaluation; describes the practices developed in Brazil, directed towards course evaluation, based on the graduate's perspective. The following descriptors were used: college graduates, indicators, evaluation and graduation available in the databases: PeriEnf, BDEnf, LILACS and DEDALUS. The analysis of the surveyed studies highlights the need to consider the opinion of college graduates in the curriculum proposals with a view to implementing an educational process with emancipating and transforming characteristics. El egresado de los cursos universitarios de enfermería enfrenta, en lo cotidiano, situaciones complejas que lo llevan a confrontar las competencias obtenidas durante el curso con las requeridas en el ejercicio profesional. Esta vivencia le permite evaluar la adecuación de la estructura pedagógica del curso y rescatar aspectos que intervienen, en ese proceso. Este texto aborda la Evaluación de Cursos Universitarios rescatando conceptos en el campo de la Evaluación Educacional; describe las prácticas desarrolladas en Brasil, dirigidas a Evaluar la Institución en el ámbito de la formación y presenta investigaciones relacionadas a la evaluación de cursos teniendo, como indicador, la perspectiva del egresado. Fueron utilizadas las palabras claves: egresados, indicadores, evaluación y graduación, disponibles en las bases de datos: PeriEnf, BDEnf, LILACS y en el banco de datos DEDALUS. el análisis de las investigaciones encontradas destaca la importancia de considerar la opinión de los egresados en la adecuación de propuestas curriculares con el objetivo de concretizar un proceso educacional con características emancipadoras y transformadoras.
Published: 2009

106. Studies on Memo, an important ErbB2 receptor-mediated component of the cellular migratory machinery

Author: Meira, Maria, Hynes, Nancy, Hofsteenge, Jan, and Gasser, Susan
Abstract: The ErbB2 receptor tyrosine kinase has been shown to play an important role in cancer cell motility and metastases formation. This receptor is often overexpressed in human tumors of diverse origins, including breast and ovarian cancer. Individuals with ErbB2 over expressing tumors have shown poor clinical outcome. Our studies are focused on signaling molecules that interact with autophosphorylated tyrosine residues of the cytoplasmic tail of the receptor. Two of the sites, Tyr 1201 (YC) and Tyr 1227 (YD) are fully able to restore the migratory phenotype of breast carcinoma cells. Studies of the functional role of ErbB2 phosphorylation sites identified PLCγ1 as an interacting partner of the YC autophosphorylation site, and Memo (Mediator of ErbB2-driven cell Motility) as a binding partner of the YD site that is required for ErbB2 induced cell motility. Memo is encoded by a unique gene that is found in all branches of life, from bacteria to humans. Memo has no characterized domains, nor does it have obvious catalytic activity. Various approaches were used to position Memo in a signaling pathway and to uncover its biochemical function. Memo was initially detected based on its important role in ErbB2- induced cell motility. In fact, tumor cells with a specific knock-down (KD) of Memo failed to grow microtubules in response to Heregulin (HRG)-induced ErbB2 activation and were impaired in their migration. Cell migration proceeds in distinct steps. In response to a chemotactic stimulus, cells extend protrusions at the front that help in attachment. This is followed by contraction of the cell body and tail detachment at the rear allowing movement in the direction of the ligand. The initial event in the process is sensing of the ligand in response to activation of cellular receptors like EGFR or ErbB2. Their activation initiates signaling pathways that lead to polymerization of new actin at the leading edge, which is necessary for generating the protrusive force allowing migration. An important goal of my thesis work has been to investigate the step(s) of the migratory process that require Memo. In the first study, we explored migration using Dunn chambers and analyzed the chemotactic response of tumor cells in a shallow gradient of ligand. By tracing HRG-stimulated cell migration in time-lapse video microscopy, we found that Memo or PLCγ1 KD strongly impairs cell directionality, reflecting an important role for Memo and PLCγ1 in orchestrating directional cell migration. We also demonstrated that depletion of Memo or PLCγ1 resulted in very similar phenotypes, with a strong impairment of HRG-induced cytoskeletal organization. To gain more insight into Memo’s function, we carried out a Yeast-2-Hybrid (YTH) analysis and found a number of interesting new partners of interaction for Memo. Of particular interest is the small protein cofilin, one of the major cellular actin severing and depolymerizing factors that is known to have an essential role in directional sensing during chemotaxis. This interaction was confirmed in vitro using recombinant proteins and in vivo in coimmunoprecipitation experiments where Memo was detected in complexes with cofilin, ErbB2 and PLCγ1. Interestingly, we also found that HRG-induced PLCγ1 phosphorylation was decreased in Memo KD cells, suggesting that Memo regulates PLCγ1 activation. Furthermore, by introducing GFP-tagged cofilin into control, Memo or PLCγ1 siRNA transfected breast tumor cells, we showed that HRG-induced recruitment of GFP-cofilin to lamellipodia is impaired in Memo- and in PLCγ1 KD cells, suggesting that both proteins lie upstream of cofilin in models of ErbB2-driven tumor cell migration. Finally, we examined the effect of Memo on cofilin binding and severing/depolymerizing properties. In vitro F-actin binding assays showed that Memo does not impair cofilin binding to F-actin, and revealed that Memo is a novel F-actin binding protein. In vitro F-actin depolymerization assays indicated that Memo promotes cofilin depolymerizing/severing activity. Altogether, these data suggest a novel role for Memo during the migratory process and its implication in the regulation of actin dynamics through cofilin binding. In the second study, we used two different Memo-defective cellular models to examine Memo’s function in more detail. We demonstrated that inhibition of Memo impairs activation of a number of signaling molecules including Src, Shc, ERK and PLCγ1. We also provide evidence that Memo interacts with the three Shc isoforms, p46shc, p52shc, and p66shc, and showed that Shc is required for Memo binding to the ErbB2 receptor. Control and Memodeficient cells were also scored for their migration and adhesion properties. These assays indicated that Memo is important in both cell migration and adhesion processes. Also, morphological and biochemical analyses of control and Memo-deficient cells suggested that Memo is involved in focal adhesion organization and rear cell deadhesion during the migratory process. Altogether, these two studies revealed important roles for Memo at different steps of cell migration and metastasis, making it a potential interesting target for cancer therapy. Genetic approaches in model organisms have been important for gaining insight into the function of evolutionarily conserved proteins. To position Memo within a genetic network, experiments in the model organism S. cerevisae that lends itself to rapid genetic screening were performed. We investigated cellular localization of Memo in yeast and found that Memo is located in the nucleus and cytoplasm of the cell. A S. cerevisae memo Δ strain has been generated and is viable. Considering the role of Memo in the microtubule and actin networks that we described in mammalian cells, we examined the memo Δ strain for defects in different cytoskeletal dynamics. No significant effect was observed. We also performed a Synthetic Lethal Screen of genetic interactions between a memo Δ strain and an ordered array of 4700 Yeast strains containing non-essential gene deletions. This analysis revealed a limited number of synthetic interactions. Lethality was observed in combination with the plc1Δ strain. PLC1 encodes for the unique isoform of phosphatidylinositol-specific phospholipase C of S. cerevisiae. The results are intriguing and exciting considering the data obtained in the mammalian models; in fact, we demonstrated that Memo and PLCγ1 interact with ErbB2 autophosphorylation sites and are essential for directional migration. We also showed that Memo is found in a complex with PLCγ1 and ErbB2 and that Memo is likely contributing to PLCγ1 activation. We hypothesize that in Yeast, Memo and PLC1 act in the same or in distinct but related pathways, and suggest that the connection between PLC and Memo induced-pathways is also conserved through evolution.
Published: 2009
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107. Para uma pedagogia integrada do ensino da língua e da literatura a falantes não nativos:a escrita ficcional de David Mourão-Ferreira

Author: Meira, Maria José da Silva Paredes, 1954 and Martins, Maria de Lourdes Câncio, 1944
Subjects: Teses de doutoramento
Abstract: Tese de doutoramento, Estudos de Literatura e de Cultura (Ensino da Literatura), 2009, Universidade de Lisboa, Faculdade de Letras Nível de preservação: critical, Criado em: 2009-11-27 16:01:39, Criado por: creator:MARTA, Alterado em: 2009-12-31 10:10:56, Modificado por: super:MARTA Made available in DSpace on 2010-06-22T09:24:01Z (GMT). No. of bitstreams: 2 20255_ulsd_re399_TD4.pdf: 2299387 bytes, checksum: cc5174202d6e9a328fcfe6e443d4294f (MD5) 20255.xml: 8601 bytes, checksum: 05695bc2ae1bb94252332d4da5ddcd84 (MD5) Previous issue date: 2009
Published: 2009

108. A arte do fazer: o artista Ruy Meira e as artes plásticas no Pará dos anos 1940 a 1980

Author: Meira, Maria Angélica Almeida de, Escolas::CPDOC, Gomes, Ângela Maria de Castro, Cavalcanti, Lauro, Oliveira, Lúcia Lippi, and Kornis, Mônica Almeida
Subjects: Modernismo, Século XX, Pará - Vida intelectual - 1940-1980, Arquivo privado, Artes plásticas no Pará, Twentieth century, Ruy Meira, Ciências sociais, Artes plásticas - Pará, Modernism, Rede de sociabilidade, Visual arts in Pará, Sociability network, Meira, Ruy, Private archive
Abstract: This work aims at studying the visual arts panorama in the State of Pará between the 1940’s and the 1980’s departing from local painter and ceramist Ruy Meira (1921-1995). Meira, a member of a distinguished family of politicians and intellectuals in Northern Brazil, played a pivotal role in the ripening of the artistic métier in Pará, having been fundamental to the establishment of many important artistic and intellectual sociability networks, and having synthesized, in his artistic trajectory, the history of the absorption of the main currents of modern art in Pará. In order to study Meira’s artistic and social personality, we searched for support in his personal archive, which contains some important material, most of it unpublished, ranging from active and passive correspondence to pictures and exhibitions catalogues. Este trabalho busca estudar o panorama das artes plásticas no Estado do Pará entre as décadas de 1940 e 1980 a partir da figura de Ruy Meira (1921-1995), pintor e ceramista paraense. Meira, membro de uma destacada família de homens públicos e intelectuais nortistas, desempenhou papel central no amadurecimento das artes no Pará, seja por ter sido fundamental para o estabelecimento de importantes redes de sociabilidade artístico-intelectuais, seja por ter, em sua trajetória artística, sintetizado a história da absorção das principais vertentes da arte moderna no Pará. Para estudar a personalidade artístico-social de Meira, buscamos apoio no arquivo pessoal do artista, que contém importante material, em boa parte inédito, constituído de correspondência ativa e passiva, fotografias e catálogos de exposição.
Published: 2008

109. Evaluación de la formación de enfermeros según la percepción de egresados

Author: Meira, Maria Dyrce Dias and Kurcgant, Paulina
Subjects: Formação profissional, Formación profesional, Pesquisa em avaliação de enfermagem, Nursing evaluation research, Education in nursing, Investigación en evaluación de enfermería, Professional formation, Educación en enfermería, Educação em enfermagem
Abstract: OBJETIVO: Apreender a percepção de egressos de um curso de graduação em Enfermagem sobre o processo de sua formação, frente às demandas que vivenciamos no cotidiano profissional para subsidiar a reformulação pedagógica do curso. MÉTODOS: Trata-se de uma pesquisa de abordagem qualitativa e o método adotado foi o Estudo de Caso. Foram entrevistados 32 enfermeiros egressos do ano de 2003 e foi utilizada a análise de conteúdo segundo Bardin. RESULTADOS: Resgataram-se cinco categorias, donde se depreende que o programa de ensino deve reforçar o desenvolvimento de competências ético-políticas; contextualizar-se segundo as políticas públicas de saúde; promover pesquisas vinculadas às demandas de saúde da comunidade; considerar a interdisciplinaridade na distribuição de conteúdos e carga horária e reforçar a formação de competências específicas, principalmente, as relacionadas à gestão em enfermagem. CONCLUSÃO: Este estudo permitiu identificar aspectos do processo formativo que interferem no cotidiano de trabalho de enfermeiros e merecem ser considerados na reestruturação dos Projetos Político Pedagógicos. OBJECTIVE: Apprehending the perception of ex-students from a Nursing undergraduate course about their educational process in view of the demands they experience in daily professional routine, in order to support the pedagogic reformulation of the course. METHODS: This is a qualitative research, and the Case Study method was adopted. Thirty-two nurses were interviewed, all of them graduated in 2003, and Bardin's content analysis was used. RESULTS: The interview yielded five categories, from which it is observed that the educational program should reinforce the development of ethical-political competences; contextualizing itself according to public healthcare policies; promoting research linked to the healthcare demands of the community; considering interdisciplinary aspects in the distribution of contents and hour load, and reinforcing the development of specific competences, especially those related to nursing management. CONCLUSION: This study allowed for the identification of aspects of the educational process that interfere in the professional routine and deserve to be considered in the restructuration of Political-Pedagogical Processes. OBJETIVO: Aprender la percepción de egresados de un curso de pregrado en Enfermería sobre el proceso de su formación, frente a las demandas vivenciadas en el cotidiano profesional, para auxiliar la reformulación pedagógica del curso. MÉTODOS: Se trata de una investigación de abordaje cualitativo cuyo método adoptado fue el Estudio de Caso. Fueron entrevistados 32 enfermeros egresados en el año 2003, utilizándose el análisis de contenido según Bardin. RESULTADOS: Se rescataron cinco categorías, concluyéndose que el programa de enseñanza debe reforzar el desarrollo de competencias ético-políticas; contextualizar de acuerdo a las políticas públicas de salud; promover investigaciones vinculadas a las demandas de salud de la comunidad; considerar la interdisciplinaridad en la distribución de contenidos y carga horaria y reforzar la formación de competencias específicas, principalmente, las relacionadas a la gestión en enfermería. CONCLUSIÓN: Este estudio permitió identificar aspectos del proceso formativo que interfieren en el cotidiano del trabajo de enfermeros y que merecen ser considerados en la reestructuración de los Proyectos Político Pedagógicos.
Published: 2008

110. Integralidade na perspectiva de enfermeiros da Estratégia Saúde da Família.

Author: da Penha Colimoide, Fabiana, Dias Meira, Maria Dyrce, Andrade Abdala, Gina, and Santos da Silva Oliveira, Sarah Lidiane
Abstract: Copyright of Revista Bioetica is the property of Conselho Federal de Medicina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2017
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111. MiR-126: a novel route for natalizumab action?

Author: Meira, Maria, primary, Sievers, Claudia, additional, Hoffmann, Francine, additional, Derfuss, Tobias, additional, Kuhle, Jens, additional, Kappos, Ludwig, additional, and Lindberg, Raija LP, additional
Published: 2014
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112. Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+T Cells of Patients with Relapsing-Remitting Multiple Sclerosis

Author: Meira, Maria, primary, Sievers, Claudia, additional, Hoffmann, Francine, additional, Rasenack, Maria, additional, Kuhle, Jens, additional, Derfuss, Tobias, additional, Kappos, Ludwig, additional, and Lindberg, Raija L. P., additional
Published: 2014
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113. Political-ethical skill development in nursing undergraduates

Author: Meira, Maria Dyrce Dias, primary and Kurcgant, Paulina, additional
Published: 2013
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114. Kleine Regulatoren mit grossem Einfluss

Author: Sievers, Claudia, primary, Meira, Maria, additional, Hoffmann, Francine, additional, and Lindberg, Raija, additional
Published: 2013
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115. IMPLANTAÇÃO DO PROGRAMA “ENFERMAGEM NA COMUNIDADE DE FÉ”: RELATO DE EXPERIÊNCIA.

Author: Abdala, Gina Andrade, De Oliveira Pimentel, Marlise, Reinert, Katia G., Slutz, Mary, Dias Meira, Maria Dyrce, and Antônio Teixeira, Carlos
Subjects: COMMUNITY health nursing, HOLISTIC medicine, PROFESSIONALISM, EDUCATION
Abstract: Copyright of Revista Brasileira em Promoção da Saúde is the property of Revista Brasileira em Promocao da Saude and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2016
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116. Nursing education: training evaluation by graduates, employers and teachers.

Author: Dias Meira, Maria Dyrce and Kurcgant, Paulina
Published: 2016
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117. MHO1, an Evolutionarily Conserved Gene, Is Synthetic Lethal with PLC1; Mho1p Has a Role in Invasive Growth

Author: Schlatter, Ivan D., primary, Meira, Maria, additional, Ueberschlag, Vanessa, additional, Hoepfner, Dominic, additional, Movva, Rao, additional, and Hynes, Nancy E., additional
Published: 2012
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118. Study of Airflow around Occupants Seated in Desks Equipped with Upper and Lower Air Terminal Devices for Slightly Warm Environments

Author: Conceicao, Eusebio, primary, Rosa, Silvia, additional, Custodio, Ana, additional, Andrade, Renata, additional, Meira, Maria, additional, Manuela, M., additional, and Lucio, J. R., additional
Published: 2010
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119. Evaluation of comfort level in desks equipped with two personalized ventilation systems in slightly warm environments

Author: Conceição, Eusébio Z.E., primary, Lúcio, Ma. Manuela J.R., additional, Rosa, Sílvia P., additional, Custódio, Ana L.V., additional, Andrade, Renata L., additional, and Meira, Maria J.P.A., additional
Published: 2010
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120. AVALIAÇÃO DE UM CURSO DE GRADUAÇÃO EM ENFERMAGEM POR EGRESSOS, EMPREGADORES E DOCENTES

Author: Meira, Maria Dyrce Dias, primary
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121. Avaliação da formação do enfermeiro: percepção de egressos de um curso de graduação em enfermagem

Author: Meira, Maria Dyrce Dias, primary
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122. O ensino de administração na graduação: percepção de enfermeiros egressos

Author: Meira, Maria Dyrce Dias, primary and Kurcgant, Paulina, additional
Published: 2009
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123. A Universidade e o Projeto Ciencia na Escola e na Familia: relato de uma experiência

Author: Moraes, Sergio Oliveira, primary and Meira, Maria Lídia Romero, additional
Published: 2009
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124. Avaliação de Curso de Graduação segundo egressos

Author: Meira, Maria Dyrce Dias, primary and Kurcgant, Paulina, additional
Published: 2009
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125. Memo is a cofilin-interacting protein that influences PLCγ1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration

Author: Meira, Maria, primary, Masson, Régis, additional, Stagljar, Igor, additional, Lienhard, Susanne, additional, Maurer, Francisca, additional, Boulay, Anne, additional, and Hynes, Nancy E., additional
Published: 2009
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126. Atividades de fala e não-fala em gagueira: estudo preliminar

Author: Andrade, Claudia Regina Furquim de, primary, Sassi, Fernanda Chiarion, additional, Juste, Fabiola Staróbole, additional, and Meira, Maria Isis Marinho, additional
Published: 2008
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127. Avaliação da formação de enfermeiros segundo a percepção de egressos

Author: Meira, Maria Dyrce Dias, primary and Kurcgant, Paulina, additional
Published: 2008
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128. SPIRITUAL CARE IN NURSING PRACTICE: NURSES' PERCEPTION.

Author: Moraes da Silva, Olga Elisa, Andrade Abdala, Gina, Almeida Silva, Iranete, and Dias Meira, Maria Dyrce
Published: 2015
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129. RELIGIOSIDADE E ESTILO DE VIDA DE UMA POPULAÇÃO ADULTA.

Author: Cres, Marli Rosangela, Abdala, Gina Andrade, Dias Meira, Maria Dyrce, Teixeira, Carlos Antonio, Lopes Lopes, Maria Fernanda Melo, and de Moraes, Maria Cecília Leite
Abstract: Copyright of Revista Brasileira em Promoção da Saúde is the property of Revista Brasileira em Promocao da Saude and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2015
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130. Exame direto no diagnóstico de Paracoccidioides brasiliensis realizados nos Laboratórios Regionais do Instituto Adolfo Lutz, São Paulo, Brasil

Author: Moreira, Sérgio S., primary, Silva, Jaqueline O., additional, Meira, Maria do Carmo A. M., additional, Galle, Leonilda C., additional, Rodrigues, Elizabete C. A., additional, Garcia, Milena Z., additional, Santos, Jane P., additional, Soares, Maria Cecília B., additional, Maria, Aguida, additional, and Silva, Rosana Bellan de Oliveira e, additional
Published: 2006
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131. Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+ T Cells of Patients with Relapsing-Remitting Multiple Sclerosis.

Author: Meira, Maria, Sievers, Claudia, Hoffmann, Francine, Rasenack, Maria, Kuhle, Jens, Derfuss, Tobias, Kappos, Ludwig, and Lindberg, Raija L. P.
Subjects: *MULTIPLE sclerosis, *PATIENT management, *GENE expression, *T cells, *CELL cycle, *NATALIZUMAB, *MATHEMATICAL models
Abstract: MicroRNAs (miRNAs) are a family of noncoding RNAs that play critical roles in the posttranscriptional regulation of gene expression. Accumulating evidence supports their involvement in the pathogenesis of multiple sclerosis (MS). Here, we compare miR-17 expressions in CD4+ T cells from relapsing-remitting (RR) MS patients treated with natalizumab versus untreated patients. miR-17 was downregulated under natalizumab treatment and upregulated during relapse, therefore supporting a possible role of miR-17 in MS immunopathogenesis. Downregulation of miR-17 was associated with upregulation of PTEN, BIM, E2F1, and p21 target genes. In vitro miR-17 inhibition was associated with upregulation of the same targets and resulted in impaired CD4+ T cell activation and proliferation. We further describe deregulated TGFBR2 expression in untreated patients versus healthy volunteers (HVs) and confirm in vitro the link between miR-17 and TGFBR2 expressions. These findings support an effect of natalizumab on expression of specific miRNA and subsequent expression of genes involved in proliferation and control of the cell cycle. [ABSTRACT FROM AUTHOR]
Published: 2014
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132. Political-ethical skill development in nursing undergraduates.

Author: Dyrce Dias Meira, Maria and Kurcgant, Paulina
Published: 2013
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133. Alterações bucais mais comuns em bebês: uma revisão de literatura e construção de Ebook.

Author: DE ALMEIDA, Eduarda Martins Fontes Cantarella, MEIRA, Maria Fernanda Cavalcante, VANIM, Manuela Marquesini, FERNANDES, Gabriela Leal Peres, and DANELON, Marcelle
Abstract: Copyright of Universidade Estadual Paulista. Revista de Odontologia is the property of Universidade Estadual Paulista. Revista de Odontologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2021

134. Nuevas Oportunidades: participar y planificar

Author: Bolay, Jean-Claude, Kullock, David, Cruz, Mabel, Meira, Maria Elisa, Bolivar, Teolinda, Pedrazzini, Yves, da Cunha, Antonio, Bolay, Jean-Claude, Pedrazzini, Yves, and da Cunha, Antonio
Subjects: Bolivia, Participatory methods, Argentina, Participatory Urban Planning, Venezuela, Brazil

135. New oportunities: Participating and Planning

Author: Bolay, Jean-Claude, Kullock, David, Cruz, Mabel, Meira, Maria Elisa, Bolivar, Teolinda, Pedrazzini, Yves, da Cunha, Antonio, Bolay, Jean-Claude, Pedrazzini, Yves, and da Cunha, Antonio
Subjects: Bolivia, Argentina, Participatory Urban Planning, Venezuela, Particpatory approaches, Brazil
Abstract: Idea shared between 1993 and 1996 between researchers from EPFL and other universities in Argentina, Bolivia, Brasil and Venezuela, with the support of the Foundation Leopold Mayer for the Progress of Man, alternative ways of urban planning have been tested in several cities of these countries, involving representatives of different institutions and social groups in a participatory form. The book makes a synthesis of actions done in each countries and offers a globa thinking about what is the aim of planning.

136. Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis.

Author: Meira, Maria, Sievers, Claudia, Hoffmann, Francine, Rasenack, Maria, Kuhle, Jens, Derfuss, Tobias, Kappos, Ludwig, and Lindberg, Raija L P
Abstract: MicroRNAs (miRNAs) are a family of noncoding RNAs that play critical roles in the posttranscriptional regulation of gene expression. Accumulating evidence supports their involvement in the pathogenesis of multiple sclerosis (MS). Here, we compare miR-17 expressions in CD4+ T cells from relapsing-remitting (RR) MS patients treated with natalizumab versus untreated patients. miR-17 was downregulated under natalizumab treatment and upregulated during relapse, therefore supporting a possible role of miR-17 in MS immunopathogenesis. Downregulation of miR-17 was associated with upregulation of PTEN, BIM, E2F1, and p21 target genes. In vitro miR-17 inhibition was associated with upregulation of the same targets and resulted in impaired CD4+ T cell activation and proliferation. We further describe deregulated TGFBR2 expression in untreated patients versus healthy volunteers (HVs) and confirm in vitro the link between miR-17 and TGFBR2 expressions. These findings support an effect of natalizumab on expression of specific miRNA and subsequent expression of genes involved in proliferation and control of the cell cycle. [ABSTRACT FROM AUTHOR]
Published: 2014
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137. Integralidade do ser humano e o cuidado no processo saúde-doença.

Author: Pereira Correa, Iara Micheline, Agrela de Andrade, Elisabete, Andrade Abdala, Gina, and Dias Meira, Maria Dyrce
Subjects: *ATTITUDE (Psychology), *HEALTH promotion, *HUMANISM, *MEDICAL care, *MEDICAL personnel, *MEDICAL practice, *NURSING practice, *NURSING models, *PATIENTS, *REFLECTION (Philosophy), *SPIRITUALITY, *COMPASSION
Abstract: Introduction: Integrality is associated with the various dimensions of life, considering the tangible and subjective aspects related to the complex unity of the human being. Objective: To promote a critical reflection on the integrality of the human being, in the scope of care, as the essence of health practices. Method: This is a study developed as a reflective essay that approached care in an existential philosophical perspective, aiming at integrality for health promotion. Development of the theme: Human care, understood as much more than doing or providing care, is projected beyond duty and becomes care and compassion. It covers attitudes that should be part of the analysis and critical reflection of professionals working in the health area. Conclusion: The recovery of integrality in the health care provided during the practice requires a reflexive posture of the health professional in order to value all the dimensions of the human being, including the spiritual one. [ABSTRACT FROM AUTHOR]
Published: 2019
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138. Gabriel Cardoso -- Dino Meira -- Maria Valejo.

Author: Valejo, Gabriel Cardoso -- Dino Meira -- Maria, performer
Published: 1974

139. A dimensão cultural-literária no ensino de uma língua estrangeira

Author: Malcato, Maria Margarida Mendes and Meira, Maria José da Silva Paredes
Subjects: Linguagem e cultura, Literatura - Estudo e ensino - Aspectos sociais, Teses de mestrado - 2014, Línguas - Estudo e ensino - Aspectos sociais
Abstract: Tese de mestrado, Língua e Cultura Portuguesa, Universidade de Lisboa, Faculdade de Letras, 2014 Submitted by Eugénia Santos (eug.santos@fl.ul.pt) on 2014-04-16T16:09:00Z No. of bitstreams: 1 ulfl155515_tm.pdf: 1953903 bytes, checksum: 43a46f07266b4ae01271074ddca81219 (MD5) Made available in DSpace on 2014-04-16T16:09:41Z (GMT). No. of bitstreams: 1 ulfl155515_tm.pdf: 1953903 bytes, checksum: 43a46f07266b4ae01271074ddca81219 (MD5) Previous issue date: 2013
Published: 2013

140. Para uma leitura intercultural de Wenceslau de Moraes: relance da alma japonesa

Author: Aboim, David Alexandre Alves, Laborinho, Ana Paula,1951, and Meira, Maria José da Silva Paredes,1954
Subjects: Linguagem e cultura, Teses de mestrado - 2012, Morais,Venceslau de,1854-1929 - Crítica e interpretação, Língua portuguesa - Estudo e ensino
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Published: 2012

141. Developing an Animal Model for Swenson Transanal Endorectal Pull-Through: A New Possibility for Training and Research Purposes.

Author: Gandra de Meira ML, Buraschi Antunes R, de Oliveira Zani V, Dutra de Oliveira G, Generoso D, Ortolan EVP, and Lourenção PLTA
Subjects: Animals, Rabbits, Anal Canal surgery, Transanal Endoscopic Surgery methods, Humans, Operative Time, Models, Animal, Rectum surgery
Abstract: As far as we know, no report uses the Swenson transanal endorectal pull-through technique in an animal model. Our objective is to describe the use of this technique as an experimental model for training and research purposes. Ten Norfolk hybrid rabbits were randomly selected from our experimental laboratory, with a mean weight of 3539.3 (± 678.4) g. Neither colon preparation nor fast were used before the procedures. The surgical technique was based on the description performed by Levitt et al. (2013, J Pediatr Surg . 2013;48(11):2289-2295). Information related to the surgical procedures and the clinical evolution in the postoperative period were recorded and analyzed. There were no deaths or severe complications. The anesthetic and the surgical times were significantly higher for the first three animals of the experiment. Our animal model proved adequate to perform the transanal endorectal Swenson pull-through technique, allowing the training of surgical skills through a model similar to the human, with few anesthetic complications and good postoperative evolution, including postoperative follow-up. We believe that it will serve as a learning tool in many institutions that are continuously searching for improved new techniques and will support new researches in this area.
Published: 2024
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142. Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings.

Author: Meira M, Frey A, Chekkat N, Rybczynska M, Sellam Z, Park JS, Gazzaniga FS, Parmentier A, Le Gall M, Freeman GJ, Kasper DL, Sharpe AH, Rambeaux E, and Shamshiev A
Subjects: Humans, Animals, Mice, Nerve Tissue Proteins immunology, Nerve Tissue Proteins antagonists & inhibitors, Ligands, Immune Checkpoint Inhibitors pharmacology, Immune Checkpoint Inhibitors immunology, Programmed Cell Death 1 Ligand 2 Protein antagonists & inhibitors, Programmed Cell Death 1 Ligand 2 Protein immunology, Protein Binding, Antibodies, Monoclonal immunology, Antibodies, Monoclonal pharmacology
Abstract: Therapeutic efficacy with durable responses has been demonstrated with several antibody drugs that block key immune checkpoint receptors, including PD-1, PD-L1, and CTLA-4. Despite the success of these drugs, a substantial proportion of patients do not benefit. Targeting multiple inhibitory pathways simultaneously to augment anti-tumor immunity has proven to be a promising approach. The emergence of Repulsive Guidance Molecule b (RGMb), a ligand for PD-L2, as a novel co-inhibitory pathway in T cells, together with its regulation by the gut microbiome, encouraged the discovery and development of fully human anti-RGMb antibodies. Here, we describe phage display-derived monoclonal antibodies (mAbs) 2C11 and 5C10 that bind human RGMb with high affinities of 1.4 nM and 0.72 nM, respectively. Both mAbs 2C11 and 5C10 potently inhibited RGMb interaction with PD-L2. MAb 2C11 effectively inhibited RGMb interaction with bone morphogenetic proteins 2 and 4 (BMP2-4), while leaving RGMb interaction with Neogenin 1 (Neo1) unaffected. Conversely, mAb 5C10 disrupted RGMb interaction with Neo1 while maintaining RGMb binding to BMP2-4. These findings map the 2C11 epitope at the membrane-distal N-terminal region of RGMb, which coincides with both PD-L2- and BMP2-4-binding sites. The PD-L2 binding interface is likely positioned between RGMb's N-terminal BMP-binding and C-terminal Neo1-binding regions. The in vivo activity of mAb 2C11 in combination with anti-PD-1 or anti-PD-L1 was tested in MC38 and B16-OVA cancer models and demonstrated synergistic effects by significantly enhancing anti-tumor responses. These properties make mAb 2C11 a promising candidate for therapeutic use to overcome immune checkpoint inhibitor resistances, warranting further exploration in clinical settings.
Published: 2024
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143. Natalizumab-induced POU2AF1/Spi-B upregulation: A possible route for PML development.

Author: Meira M, Sievers C, Hoffmann F, Haghikia A, Rasenack M, Décard BF, Kuhle J, Derfuss T, Kappos L, and Lindberg RL
Abstract: Objectives: To assess messenger RNA (mRNA) expression of POU2AF1 and Spi-B and their potential regulatory microRNAs (miRNAs) in natalizumab-treated patients with multiple sclerosis and in therapy-associated progressive multifocal leukoencephalopathy (PML)., Methods: Expression of POU2AF1/Spi-B was analyzed by using real-time reverse transcription PCR assays on isolated B/CD8(+) T lymphocytes and peripheral blood mononuclear cells (PBMCs) from cohorts of untreated and natalizumab-treated patients with and without PML. Longitudinal expression analysis was performed on CD4(+), CD8(+) T and B cells from 14 patients who interrupted natalizumab therapy for 8 weeks. The miRNA profiling was conducted in PBMCs from 5 untreated and 5 natalizumab-treated patients using low-density arrays followed by validation with single miRNAs assays in untreated and natalizumab-treated patients., Results: POU2AF1 and Spi-B mRNAs were upregulated in B and CD8(+) T cells from natalizumab-treated patients, which was validated in PBMCs from different cohorts of natalizumab-treated patients with and without PML, with a noteworthy higher expression of Spi-B in patients with PML. In contrast, downregulation of POU2AF1/Spi-B expression was measured in B and CD8(+) T cells after natalizumab discontinuation. Seventeen differentially expressed miRNAs including miR-10b, a regulator of POU2AF1 mRNA, were identified in long-term natalizumab-treated patients compared with untreated ones., Conclusions: Upregulation of POU2AF1 and Spi-B, known transactivators of the JC virus, the causative agent for PML, and its association with occurrence of PML in natalizumab-treated patients, corroborates POU2AF1/Spi-B as potential biomarkers for PML risk, which merits further evaluation.
Published: 2016
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144. Nursing education: training evaluation by graduates, employers and teachers.

Author: Meira MD and Kurcgant P
Subjects: Attitude of Health Personnel, Humans, Curriculum, Education, Nursing, Focus Groups
Abstract: Objective: to support the assessment and the necessary changes in the curriculum of an undergraduate degree in Nursing., Methods: it is a descriptive study developed in two stages as an action research. In the first stage, the speeches of 19 graduates and 15 employers were interviewed and analyzed; in the second stage, five teachers participated in the focus group. For processing the data, the content analysis was adopted., Results: based on the assessment of the actors, an action plan was created with suggestions regarding the curriculum flexibility, content resizing, continuing education, practice enhancement, active methodologies and autonomy of the student., Conclusion: the participation of actors participants of the training process and performance of professional nurses in the evaluation of a curriculum pointed aspects to realignment and provided concrete benefits to improving the quality of undergraduate course curriculum, scenario of this study.
Published: 2016
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145. MiR-126: a novel route for natalizumab action?

Author: Meira M, Sievers C, Hoffmann F, Derfuss T, Kuhle J, Kappos L, and Lindberg RL
Subjects: Adult, Antibodies, Monoclonal, Humanized adverse effects, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes metabolism, Case-Control Studies, Cells, Cultured, DNA-Binding Proteins genetics, DNA-Binding Proteins metabolism, Female, Gene Expression Regulation, Humans, Immunosuppressive Agents adverse effects, Male, MicroRNAs genetics, Middle Aged, Multiple Sclerosis diagnosis, Multiple Sclerosis genetics, Multiple Sclerosis immunology, Natalizumab, RNA, Messenger metabolism, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Trans-Activators genetics, Trans-Activators metabolism, Transcription Factors genetics, Transcription Factors metabolism, Transfection, Treatment Outcome, Antibodies, Monoclonal, Humanized therapeutic use, CD4-Positive T-Lymphocytes drug effects, Immunosuppressive Agents therapeutic use, MicroRNAs metabolism, Multiple Sclerosis drug therapy
Abstract: Background: MicroRNAs (miRNAs) have emerged as a family of post-transcriptional regulators of gene expression that mediate diverse aspects of immunity. MiRNA dysregulation has been found in multiple sclerosis (MS), reflecting the growing need to identify disease-specific miRNA expression signatures. Our previous low-density array studies reveal differential miR-126 expression in the CD4(+)T cells of untreated relapsing-remitting MS (RRMS) patients. Here, we investigated miR-126 expression in natalizumab-treated patients., Methods: We isolated CD4(+) T cells from untreated (n = 12) and natalizumab-treated MS patients (n = 24), and from healthy volunteers (n = 12). We analyzed the expression of miRNAs and potential targets by real time reverse transcription polymerase chain reaction (RT-PCR). We assessed specific inhibition of miR-126, in vitro., Results: MiR-126 was down-regulated in cells of patients under natalizumab treatment and up-regulated during relapse, supporting a regulatory role in MS immunopathogenesis. MiR-126 expression correlated with the expression of POU2AF1, a regulator of Spi-B that binds to the promoter/enhancer sequences of JC virus (JCV), the pathogen of progressive multifocal leukoencephalopathy (PML), a rare complication of natalizumab treatment. The same trend was found for Spi-B. Strong up-regulation of both genes appeared to be treatment duration-dependent. Specific inhibition experiments supported the link between the expression of miR-126 and POU2AF1/Spi-B., Conclusions: Our findings provided deeper insight into the mode of action of natalizumab, with possible implications for understanding both the effects of natalizumab on MS activity and its specific adverse event profile., (© The Author(s) 2014.)
Published: 2014
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146. [College program evaluation according to graduates].

Author: Meira MD and Kurcgant P
Subjects: Brazil, Students, Nursing, Education, Nursing standards
Abstract: Every day, college graduates face complex situations that make them check skills developed during the course in comparison with the skills needed at the professional level. This experience helps them evaluate the adequacy of the course's teaching structure and recover intervening aspects of this process. This text discusses the Evaluation of College Courses, recovering concepts in the field of Education Evaluation; describes the practices developed in Brazil, directed towards course evaluation, based on the graduate's perspective. The following descriptors were used: college graduates, indicators, evaluation and graduation available in the databases: PeriEnf, BDEnf, LILACS and DEDALUS. The analysis of the surveyed studies highlights the need to consider the opinion of college graduates in the curriculum proposals with a view to implementing an educational process with emancipating and transforming characteristics.
Published: 2009
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147. [Speech and non-speech activities in stuttering: a preliminary study].

Author: Andrade CR, Sassi FC, Juste FS, and Meira MI
Subjects: Adult, Analysis of Variance, Electromyography, Humans, Male, Muscle Relaxation physiology, Muscle Tonus physiology, Reaction Time, Speech Acoustics, Speech Production Measurement, Facial Muscles physiology, Neck Muscles physiopathology, Speech physiology, Stuttering physiopathology
Abstract: Background: stuttering., Aim: to compare muscle activation in fluent and stuttering individuals during speech and non-speech tasks., Method: six adults divided in two groups: G1 - three fluent individuals; G2 - three stuttering individuals. Muscle activity (surface electromyography) was captured by disposable electrodes fixed in four regions. Testing situations: muscle rest tension, speech reaction time, non-verbal activity, verbal activity., Results: There was no significant statistical difference between the groups for the rest tension; G2 present longer speech reaction times; G2 presented muscle activity during the non-verbal task similar to that observed during rest; Muscle activity of G1 and G2 during the verbal task demonstrated to be similar., Conclusion: these results suggests that for G2 there is a poor control of timing for the coordination of motor processes.
Published: 2008
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