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106. Stratification of amyotrophic lateral sclerosis patients: A crowdsourcing approach

Author

Kueffner, R, Zach, N, Bronfeld, M, Norel, R, Atassi, N, Balagurusamy, V, Di Camillo, B, Chio, A, Cudkowicz, M, Dillenberger, D, Garcia-Garcia, J, Hardiman, O, Hoff, B, Knight, J, Leitner, M, Li, G, Mangravite, L, Norman, T, Wang, L, Xiao, J, Fang, W, Peng, J, Yang, C, Chang, H, Stolovitzky, G, Alkallas, R, Anghel, C, Avril, J, Bacardit, J, Balser, B, Balser, J, Bar-Sinai, Y, Ben-David, N, Ben-Zion, E, Bliss, R, Cai, J, Chernyshev, A, Chiang, J, Chicco, D, Corriveau, B, Dai, J, Deshpande, Y, Desplats, E, Durgin, J, Espiritu, S, Fan, F, Fevrier, P, Fridley, B, Godzik, A, Golinska, A, Gordon, J, Graw, S, Guo, Y, Herpelinck, T, Hopkins, J, Huang, B, Jacobsen, J, Jahandideh, S, Jeon, J, Ji, W, Jung, K, Karanevich, A, Koestler, D, Kozak, M, Kurz, C, Lalansingh, C, Larrieu, T, Lazzarini, N, Lerner, B, Lesinski, W, Liang, X, Lin, X, Lowe, J, Mackey, L, Meier, R, Min, W, Mnich, K, Nahmias, V, Noel-Macdonnell, J, O'Donnell, A, Paadre, S, Park, J, Polewko-Klim, A, Raghavan, R, Rudnicki, W, Saghapour, E, Salomond, J, Sankaran, K, Sendorek, D, Sharan, V, Shiah, Y, Sirois, J, Sumanaweera, D, Usset, J, Vang, Y, Vens, C, Wadden, D, Wang, D, Wong, W, Xie, X, Xu, Z, Yang, H, Yu, X, Zhang, H, Zhang, L, Zhang, S, Zhu, S, Kueffner R., Zach N., Bronfeld M., Norel R., Atassi N., Balagurusamy V., Di Camillo B., Chio A., Cudkowicz M., Dillenberger D., Garcia-Garcia J., Hardiman O., Hoff B., Knight J., Leitner M. L., Li G., Mangravite L., Norman T., Wang L., Xiao J., Fang W. -C., Peng J., Yang C., Chang H. -J., Stolovitzky G., Alkallas R., Anghel C., Avril J., Bacardit J., Balser B., Balser J., Bar-Sinai Y., Ben-David N., Ben-Zion E., Bliss R., Cai J., Chernyshev A., Chiang J. -H., Chicco D., Corriveau B. A. N., Dai J., Deshpande Y., Desplats E., Durgin J. S., Espiritu S. M. G., Fan F., Fevrier P., Fridley B. L., Godzik A., Golinska A., Gordon J., Graw S., Guo Y., Herpelinck T., Hopkins J., Huang B., Jacobsen J., Jahandideh S., Jeon J., Ji W., Jung K., Karanevich A., Koestler D. C., Kozak M., Kurz C., Lalansingh C., Larrieu T., Lazzarini N., Lerner B., Lesinski W., Liang X., Lin X., Lowe J., Mackey L., Meier R., Min W., Mnich K., Nahmias V., Noel-Macdonnell J., O'donnell A., Paadre S., Park J., Polewko-Klim A., Raghavan R., Rudnicki W., Saghapour E., Salomond J. -B., Sankaran K., Sendorek D., Sharan V., Shiah Y. -J., Sirois J. -K., Sumanaweera D. N., Usset J., Vang Y. S., Vens C., Wadden D., Wang D., Wong W. C., Xie X., Xu Z., Yang H. -T., Yu X., Zhang H., Zhang L., Zhang S., Zhu S., Kueffner, R, Zach, N, Bronfeld, M, Norel, R, Atassi, N, Balagurusamy, V, Di Camillo, B, Chio, A, Cudkowicz, M, Dillenberger, D, Garcia-Garcia, J, Hardiman, O, Hoff, B, Knight, J, Leitner, M, Li, G, Mangravite, L, Norman, T, Wang, L, Xiao, J, Fang, W, Peng, J, Yang, C, Chang, H, Stolovitzky, G, Alkallas, R, Anghel, C, Avril, J, Bacardit, J, Balser, B, Balser, J, Bar-Sinai, Y, Ben-David, N, Ben-Zion, E, Bliss, R, Cai, J, Chernyshev, A, Chiang, J, Chicco, D, Corriveau, B, Dai, J, Deshpande, Y, Desplats, E, Durgin, J, Espiritu, S, Fan, F, Fevrier, P, Fridley, B, Godzik, A, Golinska, A, Gordon, J, Graw, S, Guo, Y, Herpelinck, T, Hopkins, J, Huang, B, Jacobsen, J, Jahandideh, S, Jeon, J, Ji, W, Jung, K, Karanevich, A, Koestler, D, Kozak, M, Kurz, C, Lalansingh, C, Larrieu, T, Lazzarini, N, Lerner, B, Lesinski, W, Liang, X, Lin, X, Lowe, J, Mackey, L, Meier, R, Min, W, Mnich, K, Nahmias, V, Noel-Macdonnell, J, O'Donnell, A, Paadre, S, Park, J, Polewko-Klim, A, Raghavan, R, Rudnicki, W, Saghapour, E, Salomond, J, Sankaran, K, Sendorek, D, Sharan, V, Shiah, Y, Sirois, J, Sumanaweera, D, Usset, J, Vang, Y, Vens, C, Wadden, D, Wang, D, Wong, W, Xie, X, Xu, Z, Yang, H, Yu, X, Zhang, H, Zhang, L, Zhang, S, Zhu, S, Kueffner R., Zach N., Bronfeld M., Norel R., Atassi N., Balagurusamy V., Di Camillo B., Chio A., Cudkowicz M., Dillenberger D., Garcia-Garcia J., Hardiman O., Hoff B., Knight J., Leitner M. L., Li G., Mangravite L., Norman T., Wang L., Xiao J., Fang W. -C., Peng J., Yang C., Chang H. -J., Stolovitzky G., Alkallas R., Anghel C., Avril J., Bacardit J., Balser B., Balser J., Bar-Sinai Y., Ben-David N., Ben-Zion E., Bliss R., Cai J., Chernyshev A., Chiang J. -H., Chicco D., Corriveau B. A. N., Dai J., Deshpande Y., Desplats E., Durgin J. S., Espiritu S. M. G., Fan F., Fevrier P., Fridley B. L., Godzik A., Golinska A., Gordon J., Graw S., Guo Y., Herpelinck T., Hopkins J., Huang B., Jacobsen J., Jahandideh S., Jeon J., Ji W., Jung K., Karanevich A., Koestler D. C., Kozak M., Kurz C., Lalansingh C., Larrieu T., Lazzarini N., Lerner B., Lesinski W., Liang X., Lin X., Lowe J., Mackey L., Meier R., Min W., Mnich K., Nahmias V., Noel-Macdonnell J., O'donnell A., Paadre S., Park J., Polewko-Klim A., Raghavan R., Rudnicki W., Saghapour E., Salomond J. -B., Sankaran K., Sendorek D., Sharan V., Shiah Y. -J., Sirois J. -K., Sumanaweera D. N., Usset J., Vang Y. S., Vens C., Wadden D., Wang D., Wong W. C., Xie X., Xu Z., Yang H. -T., Yu X., Zhang H., Zhang L., Zhang S., and Zhu S.

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of drug trials and clinical care. In this study we explored stratification through a crowdsourcing approach, the DREAM Prize4Life ALS Stratification Challenge. Using data from >10,000 patients from ALS clinical trials and 1479 patients from community-based patient registers, more than 30 teams developed new approaches for machine learning and clustering, outperforming the best current predictions of disease outcome. We propose a new method to integrate and analyze patient clusters across methods, showing a clear pattern of consistent and clinically relevant sub-groups of patients that also enabled the reliable classification of new patients. Our analyses reveal novel insights in ALS and describe for the first time the potential of a crowdsourcing to uncover hidden patient sub-populations, and to accelerate disease understanding and therapeutic development.

Published
2019

110. First Results From the Retrieved Column O/N 2 Ratio From the Ionospheric Connection Explorer (ICON): Evidence of the Impacts of Nonmigrating Tides

Author

England, Scott L., primary, Meier, R. R., additional, Frey, Harald U., additional, Mende, Stephen B., additional, Stephan, Andrew W., additional, Krier, Christopher S., additional, Cullens, Chihoko Y., additional, Wu, Yen‐Jung J., additional, Triplett, Colin C., additional, Sirk, Martin M., additional, Korpela, Eric J., additional, Harding, Brian J., additional, Englert, Christoph R., additional, and Immel, Thomas J., additional

Published
2021
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127. Exclusive measurement of the pp → nnπ+π+ reaction at 1.1 GeV

Author

Skorodko, T., Bashkanov, M., Bogoslawsky, D., Calén, H., Clement, H., Doroshkevich, E., Demiroers, L., Ekström, C., Fransson, K., Gustafsson, L., Höistad, B., Ivanov, G., Jacewicz, M., Jiganov, E., Johansson, T., Khakimova, O., Keleta, S., Koch, I., Kren, F., Kullander, S., Kupść, A., Marciniewski, P., Meier, R., Morosov, B., Pauly, C., Petrén, H., Petukhov, Y., Povtorejko, A., Ruber, R. J. M. Y., Schönning, K., Scobel, W., Shwartz, B., Stepaniak, J., Thörngren-Engblom, P., Tikhomirov, V., Wagner, G. J., Wolke, M., Yamamoto, A., Zabierowski, J., Zlomanczuk, J., and The CELSIUS/WASA Collaboration

Published
2011
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141. Single-pion production in pp collisions at 0.95 GeV/c (II)

Author

Abd El-Samad, S., Bilger, R., Brinkmann, K. -Th., Clement, H., Dietrich, M., Doroshkevich, E., Dshemuchadse, S., Ehrhardt, K., Erhardt, A., Eyrich, W., Filippi, A., Freiesleben, H., Fritsch, M., Geyer, R., Gillitzer, A., Hauffe, J., Hesselbarth, D., Jaekel, R., Jakob, B., Karsch, L., Kilian, K., Kress, J., Kuhlmann, E., Marcello, S., Marwinski, S., Meier, R., Möller, K., Morsch, H. P., Naumann, L., Ritman, J., Roderburg, E., Schönmeier, P., Schulte-Wissermann, M., Schroeder, W., Stinzing, F., Sun, G. Y., Wächter, J., Wagner, G. J., Wagner, M., Weidlich, U., Wilms, A., Wirth, S., Zhang, G., Zupranski, P., and The COSY-TOF Collaboration

Published
2009
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144. Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

Author

Kueffner R., Zach N., Bronfeld M., Norel R., Atassi N., Balagurusamy V., Di Camillo B., Chio A., Cudkowicz M., Dillenberger D., Garcia-Garcia J., Hardiman O., Hoff B., Knight J., Leitner M. L., Li G., Mangravite L., Norman T., Wang L., Xiao J., Fang W. -C., Peng J., Yang C., Chang H. -J., Stolovitzky G., Alkallas R., Anghel C., Avril J., Bacardit J., Balser B., Balser J., Bar-Sinai Y., Ben-David N., Ben-Zion E., Bliss R., Cai J., Chernyshev A., Chiang J. -H., Chicco D., Corriveau B. A. N., Dai J., Deshpande Y., Desplats E., Durgin J. S., Espiritu S. M. G., Fan F., Fevrier P., Fridley B. L., Godzik A., Golinska A., Gordon J., Graw S., Guo Y., Herpelinck T., Hopkins J., Huang B., Jacobsen J., Jahandideh S., Jeon J., Ji W., Jung K., Karanevich A., Koestler D. C., Kozak M., Kurz C., Lalansingh C., Larrieu T., Lazzarini N., Lerner B., Lesinski W., Liang X., Lin X., Lowe J., Mackey L., Meier R., Min W., Mnich K., Nahmias V., Noel-Macdonnell J., O'donnell A., Paadre S., Park J., Polewko-Klim A., Raghavan R., Rudnicki W., Saghapour E., Salomond J. -B., Sankaran K., Sendorek D., Sharan V., Shiah Y. -J., Sirois J. -K., Sumanaweera D. N., Usset J., Vang Y. S., Vens C., Wadden D., Wang D., Wong W. C., Xie X., Xu Z., Yang H. -T., Yu X., Zhang H., Zhang L., Zhang S., Zhu S., Kueffner, R, Zach, N, Bronfeld, M, Norel, R, Atassi, N, Balagurusamy, V, Di Camillo, B, Chio, A, Cudkowicz, M, Dillenberger, D, Garcia-Garcia, J, Hardiman, O, Hoff, B, Knight, J, Leitner, M, Li, G, Mangravite, L, Norman, T, Wang, L, Xiao, J, Fang, W, Peng, J, Yang, C, Chang, H, Stolovitzky, G, Alkallas, R, Anghel, C, Avril, J, Bacardit, J, Balser, B, Balser, J, Bar-Sinai, Y, Ben-David, N, Ben-Zion, E, Bliss, R, Cai, J, Chernyshev, A, Chiang, J, Chicco, D, Corriveau, B, Dai, J, Deshpande, Y, Desplats, E, Durgin, J, Espiritu, S, Fan, F, Fevrier, P, Fridley, B, Godzik, A, Golinska, A, Gordon, J, Graw, S, Guo, Y, Herpelinck, T, Hopkins, J, Huang, B, Jacobsen, J, Jahandideh, S, Jeon, J, Ji, W, Jung, K, Karanevich, A, Koestler, D, Kozak, M, Kurz, C, Lalansingh, C, Larrieu, T, Lazzarini, N, Lerner, B, Lesinski, W, Liang, X, Lin, X, Lowe, J, Mackey, L, Meier, R, Min, W, Mnich, K, Nahmias, V, Noel-Macdonnell, J, O'Donnell, A, Paadre, S, Park, J, Polewko-Klim, A, Raghavan, R, Rudnicki, W, Saghapour, E, Salomond, J, Sankaran, K, Sendorek, D, Sharan, V, Shiah, Y, Sirois, J, Sumanaweera, D, Usset, J, Vang, Y, Vens, C, Wadden, D, Wang, D, Wong, W, Xie, X, Xu, Z, Yang, H, Yu, X, Zhang, H, Zhang, L, Zhang, S, and Zhu, S

Subjects
0301 basic medicine, Drug trial, Databases, Factual, Organizations, Nonprofit, lcsh:Medicine, Disease, Neurodegenerative, Stratification (mathematics), Machine Learning, DOUBLE-BLIND, 0302 clinical medicine, Multidisciplinary approach, Cluster Analysis, Amyotrophic lateral sclerosis, lcsh:Science, PREDICTORS, Clinical Trials as Topic, Multidisciplinary, Algorithm, Multidisciplinary Sciences, Italy, SURVIVAL, Science & Technology - Other Topics, GENETIC-HETEROGENEITY, Crowdsourcing, TRIAL, CREATININE, Nonprofit, Algorithms, Human, medicine.medical_specialty, ALS Stratification Consortium, Clinical Trials and Supportive Activities, Predictive medicine, MEDLINE, Article, 03 medical and health sciences, Databases, Rare Diseases, Clinical Research, medicine, Humans, Intensive care medicine, Factual, Organizations, Cluster Analysi, Science & Technology, business.industry, DEXPRAMIPEXOLE, lcsh:R, DISEASE PROGRESSION, Amyotrophic Lateral Sclerosis, Neurosciences, OUTCOME MEASURES, medicine.disease, Brain Disorders, Clinical trial, BODY-MASS INDEX, 030104 developmental biology, Orphan Drug, Good Health and Well Being, ING-IND/34 - BIOINGEGNERIA INDUSTRIALE, lcsh:Q, ALS, business, Ireland, 030217 neurology & neurosurgery, Amyotrophic Lateral Sclerosi
Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of drug trials and clinical care. In this study we explored stratification through a crowdsourcing approach, the DREAM Prize4Life ALS Stratification Challenge. Using data from >10,000 patients from ALS clinical trials and 1479 patients from community-based patient registers, more than 30 teams developed new approaches for machine learning and clustering, outperforming the best current predictions of disease outcome. We propose a new method to integrate and analyze patient clusters across methods, showing a clear pattern of consistent and clinically relevant sub-groups of patients that also enabled the reliable classification of new patients. Our analyses reveal novel insights in ALS and describe for the first time the potential of a crowdsourcing to uncover hidden patient sub-populations, and to accelerate disease understanding and therapeutic development. ispartof: SCIENTIFIC REPORTS vol:9 issue:1 ispartof: location:England status: published

Published
2019

147. Crystal structure of BAY-297 with PIP4K2A

Author

Holton, S.J., primary, Wortmann, L., additional, Braeuer, N., additional, Irlbacher, H., additional, Weiske, J., additional, Lechner, C., additional, Meier, R., additional, Puetter, V., additional, Christ, C., additional, ter Laak, T., additional, Lienau, P., additional, Lesche, R., additional, Nicke, B., additional, Bauser, M., additional, Haegebarth, A., additional, von Nussbaum, F., additional, Mumberg, D., additional, and Lemos, C., additional

Published
2021
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148. Crystal structure of Compound 1 with PIP4K2A

Author

Holton, S.J., primary, Wortmann, L., additional, Braeuer, N., additional, Irlbacher, H., additional, Weiske, J., additional, Lechner, C., additional, Meier, R., additional, Puetter, V., additional, Christ, C., additional, ter Laak, T., additional, Lienau, P., additional, Lesche, R., additional, Nicke, B., additional, Bauser, M., additional, Haegebarth, A., additional, von Nussbaum, F., additional, Mumberg, D., additional, and Lemos, C., additional

Published
2021
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149. Crystal structure of BAY-091 with PIP4K2A

Author

Holton, S.J., primary, Wortmann, L., additional, Braeuer, N., additional, Irlbacher, H., additional, Weiske, J., additional, Lechner, C., additional, Meier, R., additional, Puetter, V., additional, Christ, C., additional, ter Laak, T., additional, Lienau, P., additional, Lesche, R., additional, Nicke, B., additional, Bauser, M., additional, Haegebarth, A., additional, von Nussbaum, F., additional, Mumberg, D., additional, and Lemos, C., additional

Published
2021
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