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103. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

Author

Landi, Maria Teresa, Chatterjee, Nilanjan, Kai Yu, Goldin, Lynn R., Goldstein, Alisa M., Rotunno, Melissa, Mirabello, Lisa, Jacobs, Kevin, Wheeler, William, Yeager, Meredith, Bergen, Andrew W., Qizhai Li, Consonni, Dario, Pesatori, Angela C., Wacholder, Sholom, Thun, Michael, Diver, Ryan, Oken, Martin, Virtamo, Jarmo, Albanes, Demetrius, Zhaoming Wang, Burdette, Laurie, Doheny, Kimberly F., Pugh, Elizabeth W., Laurie, Cathy, Brennan, Paul, Rayjean Hung, Gaborieau, Valerie, McKay, James D., Lathrop, Mark, McLaughlin, John, Ying Wang, Ming-Sound Tsao, Spitz, Margaret R., Yufei Wang, Krokan, Hans, Vatten, Lars, Skorpen, Frank, Arnesen, Egil, and Benhamou, Simone

Subjects
Adenocarcinoma -- Genetic aspects, Human genome -- Research, Single nucleotide polymorphisms -- Analysis, Biological sciences
Abstract

Several genome-wide association studies are conducted to identify the different genetic loci that can be associated with lung cancer in humans. The analysis reveals the presence of a region of chromosome 5p15, which is shown to be widely related to the risk of adenocarcinoma.

Published
2009

105. Studying the Utility of Using Genetics to Predict Smoking-Related Outcomes in a Population-Based Study and a Selected Cohort

Author

Bray, Michael J, primary, Chen, Li-Shiun, additional, Fox, Louis, additional, Ma, Yinjiao, additional, Grucza, Richard A, additional, Hartz, Sarah M, additional, Culverhouse, Robert C, additional, Saccone, Nancy L, additional, Hancock, Dana B, additional, Johnson, Eric O, additional, McKay, James D, additional, Baker, Timothy B, additional, and Bierut, Laura J, additional

Published
2021
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106. The PI3K/mTOR Pathway Is Targeted by Rare Germline Variants in Patients with Both Melanoma and Renal Cell Carcinoma

Author

Hubert, Jean-Noël, primary, Suybeng, Voreak, additional, Vallée, Maxime, additional, Delhomme, Tiffany M., additional, Maubec, Eve, additional, Boland, Anne, additional, Bacq, Delphine, additional, Deleuze, Jean-François, additional, Jouenne, Fanélie, additional, Brennan, Paul, additional, McKay, James D., additional, Avril, Marie-Françoise, additional, Bressac-de Paillerets, Brigitte, additional, and Chanudet, Estelle, additional

Published
2021
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107. Transcriptome-wide association study reveals candidate causal genes for lung cancer

Author

Bosse, Yohan, Li, Zhonglin, Xia, Jun, Manem, Venkata, Carreras-Torres, Robert, Gabriel, Aurelie, Gaudreault, Nathalie, Albanes, Demetrius, Aldrich, Melinda C., Andrew, Angeline, Arnold, Susanne, Bickeboeller, Heike, Bojesen, Stig E., Brennan, Paul, Brunnstrom, Hans, Caporaso, Neil, Chen, Chu, Christiani, David C., Field, John K., Goodman, Gary, Grankvist, Kjell, Houlston, Richard, Johansson, Mattias, Johansson, Mikael, Kiemeney, Lambertus A., Lam, Stephen, Landi, Maria T., Lazarus, Philip, Le Marchand, Loic, Liu, Geoffrey, Melander, Olle, Rennert, Gadi, Risch, Angela, Rosenberg, Susan M., Schabath, Matthew B., Shete, Sanjay, Song, Zhuoyi, Stevens, Victoria L., Tardon, Adonina, Wichmann, H-Erich, Woll, Penella, Zienolddiny, Shan, Obeidat, Ma'en, Timens, Wim, Hung, Rayjean J., Joubert, Philippe, Amos, Christopher I., McKay, James D., Bosse, Yohan, Li, Zhonglin, Xia, Jun, Manem, Venkata, Carreras-Torres, Robert, Gabriel, Aurelie, Gaudreault, Nathalie, Albanes, Demetrius, Aldrich, Melinda C., Andrew, Angeline, Arnold, Susanne, Bickeboeller, Heike, Bojesen, Stig E., Brennan, Paul, Brunnstrom, Hans, Caporaso, Neil, Chen, Chu, Christiani, David C., Field, John K., Goodman, Gary, Grankvist, Kjell, Houlston, Richard, Johansson, Mattias, Johansson, Mikael, Kiemeney, Lambertus A., Lam, Stephen, Landi, Maria T., Lazarus, Philip, Le Marchand, Loic, Liu, Geoffrey, Melander, Olle, Rennert, Gadi, Risch, Angela, Rosenberg, Susan M., Schabath, Matthew B., Shete, Sanjay, Song, Zhuoyi, Stevens, Victoria L., Tardon, Adonina, Wichmann, H-Erich, Woll, Penella, Zienolddiny, Shan, Obeidat, Ma'en, Timens, Wim, Hung, Rayjean J., Joubert, Philippe, Amos, Christopher I., and McKay, James D.

Abstract

We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large‐scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n = 1,038) to identify candidate causal genes for lung cancer. We performed transcriptome‐wide association study (TWAS) for lung cancer overall, by histology (adenocarcinoma, squamous cell carcinoma and small cell lung cancer) and smoking subgroups (never‐ and ever‐smokers). We performed replication analysis using lung data from the Genotype‐Tissue Expression (GTEx) project. DNA damage assays were performed in human lung fibroblasts for selected TWAS genes. As expected, the main TWAS signal for all histological subtypes and ever‐smokers was on chromosome 15q25. The gene most strongly associated with lung cancer at this locus using the TWAS approach was IREB2 (pTWAS = 1.09E−99), where lower predicted expression increased lung cancer risk. A new lung adenocarcinoma susceptibility locus was revealed on 9p13.3 and associated with higher predicted expression of AQP3 (pTWAS = 3.72E−6). Among the 45 previously described lung cancer GWAS loci, we mapped candidate target gene for 17 of them. The association AQP3‐adenocarcinoma on 9p13.3 was replicated using GTEx (pTWAS = 6.55E−5). Consistent with the effect of risk alleles on gene expression levels, IREB2 knockdown and AQP3 overproduction promote endogenous DNA damage. These findings indicate genes whose expression in lung tissue directly influences lung cancer risk.

Published
2020
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108. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Saberi Hosnijeh, Fatemeh, Kolijn, Pieter M, Casabonne, Delphine, Nieters, Alexandra, Solans, Marta, Naudin, Sabine, Ferrari, Pietro, Mckay, James D, Weiderpass, Elisabete, Perduca, Vittorio, Besson, Caroline, Mancini, Francesca Romana, Masala, Giovanna, Krogh, Vittorio, Ricceri, Fulvio, Huerta, José M, Petrova, Dafina, Sala, Núria, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Kaaks, Rudolf, Canzian, Federico, Aune, Dagfinn, Boeing, Heiner, Schulze, Matthias B, Perez-Cornago, Aurora, Langerak, Anton W, van der Velden, Vincent H J, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Saberi Hosnijeh, Fatemeh, Kolijn, Pieter M, Casabonne, Delphine, Nieters, Alexandra, Solans, Marta, Naudin, Sabine, Ferrari, Pietro, Mckay, James D, Weiderpass, Elisabete, Perduca, Vittorio, Besson, Caroline, Mancini, Francesca Romana, Masala, Giovanna, Krogh, Vittorio, Ricceri, Fulvio, Huerta, José M, Petrova, Dafina, Sala, Núria, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Kaaks, Rudolf, Canzian, Federico, Aune, Dagfinn, Boeing, Heiner, Schulze, Matthias B, Perez-Cornago, Aurora, Langerak, Anton W, van der Velden, Vincent H J, and Vermeulen, Roel

Published
2020

110. Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Author

Lesseur, Corina, primary, Ferreiro-Iglesias, Aida, additional, McKay, James D., additional, Bossé, Yohan, additional, Johansson, Mattias, additional, Gaborieau, Valerie, additional, Landi, Maria Teresa, additional, Christiani, David C., additional, Caporaso, Neil C., additional, Bojesen, Stig E., additional, Amos, Christopher I., additional, Shete, Sanjay, additional, Liu, Geoffrey, additional, Rennert, Gadi, additional, Albanes, Demetrius, additional, Aldrich, Melinda C., additional, Tardon, Adonina, additional, Chen, Chu, additional, Triantafillos, Liloglou, additional, Field, John K., additional, Teare, Marion Dawn, additional, Kiemeney, Lambertus A., additional, Diergaarde, Brenda, additional, Ferris, Robert L., additional, Zienolddiny, Shanbeh, additional, Lam, Stephen, additional, Olshan, Andrew F., additional, Weissler, Mark C., additional, Lacko, Martin, additional, Risch, Angela, additional, Bickeböller, Heike, additional, Ness, Andy R., additional, Thomas, Steve, additional, Le Marchand, Loic, additional, Schabath, Matthew B., additional, Wünsch-Filho, Victor, additional, Tajara, Eloiza H., additional, Andrew, Angeline S., additional, Clifford, Gary M., additional, Lazarus, Philip, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Arnold, Susanne, additional, Melander, Olle, additional, Brunnström, Hans, additional, Boccia, Stefania, additional, Cadoni, Gabriella, additional, Timens, Wim, additional, Obeidat, Ma’en, additional, Xiao, Xiangjun, additional, Houlston, Richard S., additional, Hung, Rayjean J., additional, and Brennan, Paul, additional

Published
2021
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111. Sequencing at lymphoid neoplasm susceptibility loci maps six myeloma risk genes

Author

Waller, Rosalie Griffin, primary, Klein, Robert J, additional, Vijai, Joseph, additional, McKay, James D, additional, Clay-Gilmour, Alyssa, additional, Wei, Xiaomu, additional, Madsen, Michael J, additional, Sborov, Douglas W, additional, Curtin, Karen, additional, Slager, Susan L, additional, Offit, Kenneth, additional, Vachon, Celine M, additional, Lipkin, Steven M, additional, Dumontet, Charles, additional, and Camp, Nicola J, additional

Published
2021
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112. Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model

Author

Hung, Rayjean J., primary, Warkentin, Matthew T., additional, Brhane, Yonathan, additional, Chatterjee, Nilanjan, additional, Christiani, David C., additional, Landi, Maria Teresa, additional, Caporaso, Neil E., additional, Liu, Geoffrey, additional, Johansson, Mattias, additional, Albanes, Demetrius, additional, Marchand, Loic Le, additional, Tardon, Adonina, additional, Rennert, Gad, additional, Bojesen, Stig E., additional, Chen, Chu, additional, Field, John K., additional, Kiemeney, Lambertus A., additional, Lazarus, Philip, additional, Zienolddiny, Shanbeth, additional, Lam, Stephen, additional, Andrew, Angeline S., additional, Arnold, Susanne M., additional, Aldrich, Melinda C., additional, Bickeböller, Heike, additional, Risch, Angela, additional, Schabath, Matthew B., additional, McKay, James D., additional, Brennan, Paul, additional, and Amos, Christopher I., additional

Published
2021
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114. Mutations in a novel gene, NHS, cause the pleiotropic effects of Nance-Horan Syndrome, including severe congenital cataract, dental anomalies, and mental retardation

Author

Burdon, Kathryn P., McKay, James D., Sale, Michele M., Russell-Eggitt, Isabelle M., Mackey, David A., Wirth, M. Gabriela, Elder, James E., Nicoll, Alan, Clarke, Michael P., FitzGerald, Liesel M., Stankovich, James M., Shaw, Marie A., Sharma, Shiwani, Gajovic, Srecko, Gruss, Peter, Ross, Shelley, Thomas, Paul, Voss, Anne K., Thomas, Tim, Gecz, Jozef, and Craig, Jamie E.

Subjects
Human genetics -- Research, Biological sciences
Published
2003

115. Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

Author

Timofeeva, Maria N., Hung, Rayjean J., Rafnar, Thorunn, Christiani, David C., Field, John K., Bickeböller, Heike, Risch, Angela, McKay, James D., Wang, Yufei, Dai, Juncheng, Gaborieau, Valerie, McLaughlin, John, Brenner, Darren, Narod, Steven A., Caporaso, Neil E., Albanes, Demetrius, Thun, Michael, Eisen, Timothy, Wichmann, H.-Erich, Rosenberger, Albert, Han, Younghun, Chen, Wei, Zhu, Dakai, Spitz, Margaret, Wu, Xifeng, Pande, Mala, Zhao, Yang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Krokan, Hans E., Gabrielsen, Maiken Elvestad, Skorpen, Frank, Vatten, Lars, Njølstad, Inger, Chen, Chu, Goodman, Gary, Lathrop, Mark, Benhamou, Simone, Vooder, Tõnu, Välk, Kristjan, Nelis, Mari, Metspalu, Andres, Raji, Olaide, Chen, Ying, Gosney, John, Liloglou, Triantafillos, Muley, Thomas, Dienemann, Hendrik, Thorleifsson, Gudmar, Shen, Hongbing, Stefansson, Kari, Brennan, Paul, Amos, Christopher I., Houlston, Richard, and Landi, Maria Teresa

Published
2012
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117. The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma

Author

Han, Summer S., Yeager, Meredith, Moore, Lee E., Wei, Ming-Hui, Pfeiffer, Ruth, Toure, Ousmane, Purdue, Mark P., Johansson, Mattias, Scelo, Ghislaine, Chung, Charles C., Gaborieau, Valerie, Zaridze, David, Schwartz, Kendra, Szeszenia-Dabrowska, Neonilia, Davis, Faith, Bencko, Vladimir, Colt, Joanne S., Janout, Vladimir, Matveev, Vsevolod, Foretova, Lenka, Mates, Dana, Navratilova, M., Boffetta, Paolo, Berg, Christine D., Grubb, Robert L., III, Stevens, Victoria L., Thun, Michael J., Diver, W. Ryan, Gapstur, Susan M., Albanes, Demetrius, Weinstein, Stephanie J., Virtamo, Jarmo, Burdett, Laurie, Brisuda, Antonin, McKay, James D., Fraumeni, Joseph F., Jr, Chatterjee, Nilanjan, Rosenberg, Philip S., Rothman, Nathaniel, Brennan, Paul, Chow, Wong-Ho, Tucker, Margaret A., Chanock, Stephen J., and Toro, Jorge R.

Published
2012
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118. Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups

Author

Urayama, Kevin Y., Jarrett, Ruth F., Hjalgrim, Henrik, Diepstra, Arjan, Kamatani, Yoichiro, Chabrier, Amelie, Gaborieau, Valerie, Boland, Anne, Nieters, Alexandra, Becker, Nikolaus, Foretova, Lenka, Benavente, Yolanda, Maynadié, Marc, Staines, Anthony, Shield, Lesley, Lake, Annette, Montgomery, Dorothy, Taylor, Malcolm, Smedby, Karin Ekström, Amini, Rose-Marie, Adami, Hans-Olov, Glimelius, Bengt, Feenstra, Bjarke, Nolte, Ilja M., Visser, Lydia, van Imhoff, Gustaaf W., Lightfoot, Tracy, Cocco, Pierluigi, Kiemeney, Lambertus, Vermeulen, Sita H., Holcatova, Ivana, Vatten, Lars, Macfarlane, Gary J., Thomson, Peter, Conway, David I., Benhamou, Simone, Agudo, Antonio, Healy, Claire M., Overvad, Kim, Tjønneland, Anne, Melin, Beatrice, Canzian, Federico, Khaw, Kay-Tee, Travis, Ruth C., Peeters, Petra H. M., González, Carlos A., Quirós, José Ramón, Sánchez, María-José, Huerta, José María, Ardanaz, Eva, Dorronsoro, Miren, Clavel-Chapelon, Françoise, Bueno-de-Mesquita, H. Bas, Riboli, Elio, Roman, Eve, Boffetta, Paolo, de Sanjosé, Silvia, Zelenika, Diana, Melbye, Mads, van den Berg, Anke, Lathrop, Mark, Brennan, Paul, and McKay, James D.

Published
2012
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119. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

Author

Wu, Xifeng, Scelo, Ghislaine, Purdue, Mark P., Rothman, Nathaniel, Johansson, Mattias, Ye, Yuanqing, Wang, Zhaoming, Zelenika, Diana, Moore, Lee E., Wood, Christopher G., Prokhortchouk, Egor, Gaborieau, Valerie, Jacobs, Kevin B., Chow, Wong-Ho, Toro, Jorge R., Zaridze, David, Lin, Jie, Lubinski, Jan, Trubicka, Joanna, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Jinga, Viorel, Bencko, Vladimir, Slamova, Alena, Holcatova, Ivana, Navratilova, Marie, Janout, Vladimir, Boffetta, Paolo, Colt, Joanne S., Davis, Faith G., Schwartz, Kendra L., Banks, Rosamonde E., Selby, Peter J., Harnden, Patricia, Berg, Christine D., Hsing, Ann W., Grubb, Robert L., III, Boeing, Heiner, Vineis, Paolo, Clavel-Chapelon, Françoise, Palli, Domenico, Tumino, Rosario, Krogh, Vittorio, Panico, Salvatore, Duell, Eric J., Quirós, José Ramón, Sanchez, Maria-José, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E., Bueno-de-Mesquita, H. Bas, Peeters, Petra H.M., Trichopoulos, Dimitrios, Linseisen, Jakob, Ljungberg, Börje, Overvad, Kim, Tjønneland, Anne, Romieu, Isabelle, Riboli, Elio, Stevens, Victoria L, Thun, Michael J, Diver, W. Ryan, Gapstur, Susan M., Pharoah, Paul D., Easton, Douglas F., Albanes, Demetrius, Virtamo, Jarmo, Vatten, Lars, Hveem, Kristian, Fletcher, Tony, Koppova, Kvetoslava, Cussenot, Olivier, Cancel-Tassin, Geraldine, Benhamou, Simone, Hildebrandt, Michelle A., Pu, Xia, Foglio, Mario, Lechner, Doris, Hutchinson, Amy, Yeager, Meredith, Fraumeni, Joseph F., Jr, Lathrop, Mark, Skryabin, Konstantin G., McKay, James D., Gu, Jian, Brennan, Paul, and Chanock, Stephen J.

Published
2012
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120. Genome-wide association study of HPV seropositivity

Author

Chen, Dan, McKay, James D., Clifford, Gary, Gaborieau, Valérie, Chabrier, Amélie, Waterboer, Tim, Zaridze, David, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Bencko, Vladimir, Janout, Vladimir, Foretova, Lenka, Mates, Ioan Nicolae, Szeszenia-Dabrowska, Neonila, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, José, Fernández Garrote, Leticia, Matos, Elena, Zelenika, Diana, Boland, Anne, Boffetta, Paolo, Pawlita, Michael, Lathrop, Mark, and Brennan, Paul

Published
2011
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121. Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer—a finding from Texas lung cancer genome-wide association study

Author

Wei, Sheng, Niu, Jiangong, Zhao, Hui, Liu, Zhensheng, Wang, Li-E, Han, Younghun, Chen, Wei V., Amos, Christopher I., Rafnar, Thorunn, Sulem, Patrick, Stefansson, Kari, Landi, Maria T., Caporaso, Neil E., Albanes, Demetrius, Thun, Michael J., McKay, James D., Brennan, Paul, Wang, Yufei, Houlston, Richard S., Spitz, Margaret R., and Wei, Qingyi

Published
2011
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122. Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer

Author

Liu, Zhiwei, primary, Derkach, Andriy, additional, Yu, Kelly J., additional, Yeager, Meredith, additional, Chang, Yu-Sun, additional, Chen, Chien-Jen, additional, Gyllensten, Ulf, additional, Lan, Qing, additional, Lee, Mei-Hsuan, additional, McKay, James D., additional, Rothman, Nathaniel, additional, Yang, Hwai-I, additional, Hildesheim, Allan, additional, and Pfeiffer, Ruth M., additional

Published
2020
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123. Development of Sensitive Droplet Digital PCR Assays for Detecting Urinary TERT Promoter Mutations as Non-Invasive Biomarkers for Detection of Urothelial Cancer

Author

Hosen, Md Ismail, primary, Forey, Nathalie, additional, Durand, Geoffroy, additional, Voegele, Catherine, additional, Bilici, Selin, additional, Avogbe, Patrice Hodonou, additional, Delhomme, Tiffany Myriam, additional, Foll, Matthieu, additional, Manel, Arnaud, additional, Vian, Emmanuel, additional, Meziani, Sonia, additional, De Tilly, Berengere, additional, Polo, Gilles, additional, Lole, Olesia, additional, Francois, Pauline, additional, Boureille, Antoine, additional, Pisarev, Eduard, additional, Salas, Andrei R. O. S. E., additional, Monteiro-Reis, Sara, additional, Henrique, Rui, additional, Byrnes, Graham, additional, Jeronimo, Carmen, additional, Scelo, Ghislaine, additional, McKay, James D., additional, Calvez-Kelm, Florence Le, additional, and Zvereva, Maria, additional

Published
2020
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124. Association between anthropometry and lifestyle factors and risk of B‐cell lymphoma: An exposome‐wide analysis

Author

Saberi Hosnijeh, Fatemeh, primary, Casabonne, Delphine, additional, Nieters, Alexandra, additional, Solans, Marta, additional, Naudin, Sabine, additional, Ferrari, Pietro, additional, Mckay, James D., additional, Benavente, Yolanda, additional, Weiderpass, Elisabete, additional, Freisling, Heinz, additional, Severi, Gianluca, additional, Boutron Ruault, Marie‐Christine, additional, Besson, Caroline, additional, Agnoli, Claudia, additional, Masala, Giovanna, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Huerta, José María, additional, Amiano, Pilar, additional, Rodriguez‐Barranco, Miguel, additional, Bonet, Catalina, additional, Barricarte, Aurelio, additional, Christakoudi, Sofia, additional, Knuppel, Anika, additional, Bueno‐de‐Mesquita, Bas, additional, Schulze, Matthias B., additional, Kaaks, Rudolf, additional, Canzian, Federico, additional, Späth, Florentin, additional, Jerkeman, Mats, additional, Rylander, Charlotta, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Borch, Kristin Benjaminsen, additional, and Vermeulen, Roel, additional

Published
2020
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125. A molecular map of lung neuroendocrine neoplasms

Author

Gabriel, Aurélie A G, primary, Mathian, Emilie, additional, Mangiante, Lise, additional, Voegele, Catherine, additional, Cahais, Vincent, additional, Ghantous, Akram, additional, McKay, James D, additional, Alcala, Nicolas, additional, Fernandez-Cuesta, Lynnette, additional, and Foll, Matthieu, additional

Published
2020
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126. Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Author

Mullins, Niamh, primary, Forstner, Andreas J., additional, O’Connell, Kevin S., additional, Coombes, Brandon, additional, Coleman, Jonathan R. I., additional, Qiao, Zhen, additional, Als, Thomas D., additional, Bigdeli, Tim B., additional, Børte, Sigrid, additional, Bryois, Julien, additional, Charney, Alexander W., additional, Drange, Ole Kristian, additional, Gandal, Michael J., additional, Hagenaars, Saskia P., additional, Ikeda, Masashi, additional, Kamitaki, Nolan, additional, Kim, Minsoo, additional, Krebs, Kristi, additional, Panagiotaropoulou, Georgia, additional, Schilder, Brian M., additional, Sloofman, Laura G., additional, Steinberg, Stacy, additional, Trubetskoy, Vassily, additional, Winsvold, Bendik S., additional, Won, Hong-Hee, additional, Abramova, Liliya, additional, Adorjan, Kristina, additional, Agerbo, Esben, additional, Al Eissa, Mariam, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Antoniou, Anastasia, additional, Awasthi, Swapnil, additional, Baek, Ji Hyun, additional, Bækvad-Hansen, Marie, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Beins, Eva C., additional, Bergen, Sarah E., additional, Birner, Armin, additional, Bøcker Pedersen, Carsten, additional, Bøen, Erlend, additional, Boks, Marco P., additional, Bosch, Rosa, additional, Brum, Murielle, additional, Brumpton, Ben M., additional, Brunkhorst-Kanaan, Nathalie, additional, Budde, Monika, additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cairns, Murray, additional, Casas, Miquel, additional, Cervantes, Pablo, additional, Clarke, Toni-Kim, additional, Cruceanu, Cristiana, additional, Cuellar-Barboza, Alfredo, additional, Cunningham, Julie, additional, Curtis, David, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Dalkner, Nina, additional, David, Friederike S., additional, Degenhardt, Franziska, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Douzenis, Athanassios, additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Ferrier, I. Nicol, additional, Fiorentino, Alessia, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Frei, Oleksandr, additional, Freimer, Nelson B., additional, Frisén, Louise, additional, Gade, Katrin, additional, Garnham, Julie, additional, Gelernter, Joel, additional, Giørtz Pedersen, Marianne, additional, Gizer, Ian R., additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Greenwood, Tiffany A., additional, Grove, Jakob, additional, Guzman-Parra, José, additional, Ha, Kyooseob, additional, Haraldsson, Magnus, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hellgren, Dennis, additional, Herms, Stefan, additional, Hoffmann, Per, additional, Holmans, Peter A., additional, Huckins, Laura, additional, Jamain, Stéphane, additional, Johnson, Jessica S., additional, Kalman, Janos L., additional, Kamatani, Yoichiro, additional, Kennedy, James L., additional, Kittel-Schneider, Sarah, additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Koromina, Maria, additional, Kranz, Thorsten M., additional, Kranzler, Henry R., additional, Kubo, Michiaki, additional, Kupka, Ralph, additional, Kushner, Steven A., additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Leber, Markus, additional, Lee, Heon-Jeong, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Lewis, Catrin, additional, Liao, Calwing, additional, Lucae, Susanne, additional, Lundberg, Martin, additional, MacIntyre, Donald J., additional, Magnusson, Sigurdur H., additional, Maier, Wolfgang, additional, Maihofer, Adam, additional, Malaspina, Dolores, additional, Maratou, Eirini, additional, Martinsson, Lina, additional, Mattheisen, Manuel, additional, McCarroll, Steven A., additional, McGregor, Nathaniel W., additional, McGuffin, Peter, additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Millischer, Vincent, additional, Montgomery, Grant W., additional, Moran, Jennifer L., additional, Morris, Derek W., additional, Mühleisen, Thomas W., additional, O’Brien, Niamh, additional, O’Donovan, Claire, additional, Loohuis, Loes M. Olde, additional, Oruc, Lilijana, additional, Papiol, Sergi, additional, Pardiñas, Antonio F., additional, Perry, Amy, additional, Pfennig, Andrea, additional, Porichi, Evgenia, additional, Potash, James B., additional, Quested, Digby, additional, Raj, Towfique, additional, Rapaport, Mark H., additional, DePaulo, J. Raymond, additional, Regeer, Eline J., additional, Rice, John P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roth, Julian, additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Sánchez-Mora, Cristina, additional, Schulte, Eva C., additional, Senner, Fanny, additional, Sharp, Sally, additional, Shilling, Paul D., additional, Sigurdsson, Engilbert, additional, Sirignano, Lea, additional, Slaney, Claire, additional, Smeland, Olav B., additional, Smith, Daniel J., additional, Sobell, Janet L., additional, Søholm Hansen, Christine, additional, Artigas, Maria Soler, additional, Spijker, Anne T., additional, Stein, Dan J., additional, Strauss, John S., additional, Świątkowska, Beata, additional, Terao, Chikashi, additional, Thorgeirsson, Thorgeir E., additional, Toma, Claudio, additional, Tooney, Paul, additional, Tsermpini, Evangelia-Eirini, additional, Vawter, Marquis P., additional, Vedder, Helmut, additional, Walters, James T. R., additional, Witt, Stephanie H., additional, Xi, Simon, additional, Xu, Wei, additional, Yang, Jessica Mei Kay, additional, Young, Allan H., additional, Young, Hannah, additional, Zandi, Peter P., additional, Zhou, Hang, additional, Zillich, Lea, additional, Psychiatry, HUNT All-In, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Alfredsson, Lars, additional, Babadjanova, Gulja, additional, Backlund, Lena, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Bengesser, Susanne, additional, Berrettini, Wade H., additional, Blackwood, Douglas H. R., additional, Boehnke, Michael, additional, Børglum, Anders D., additional, Breen, Gerome, additional, Carr, Vaughan J., additional, Catts, Stanley, additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Dannlowski, Udo, additional, Dikeos, Dimitris, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Ferentinos, Panagiotis, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gawlik, Micha, additional, Gershon, Elliot S., additional, Goes, Fernando S., additional, Green, Melissa J., additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Henskens, Frans, additional, Hillert, Jan, additional, Hong, Kyung Sue, additional, Hougaard, David M., additional, Hultman, Christina M., additional, Hveem, Kristian, additional, Iwata, Nakao, additional, Jablensky, Assen V., additional, Jones, Ian, additional, Jones, Lisa A., additional, S. Kahn, René, additional, Kelsoe, John R., additional, Kirov, George, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Cathryn M., additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Lochner, Christine, additional, Loughland, Carmel, additional, Martin, Nicholas G., additional, Mathews, Carol A., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, Melle, Ingrid, additional, Michie, Patricia, additional, Milani, Lili, additional, Mitchell, Philip B., additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Mowry, Bryan, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M., additional, Neale, Benjamin M., additional, Nievergelt, Caroline M., additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O’Donovan, Michael C., additional, Oedegaard, Ketil J., additional, Olsson, Tomas, additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pantelis, Chris, additional, Pato, Carlos, additional, Pato, Michele T., additional, Patrinos, George P., additional, Perlis, Roy H., additional, Posthuma, Danielle, additional, Ramos-Quiroga, Josep Antoni, additional, Reif, Andreas, additional, Reininghaus, Eva Z., additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Ripke, Stephan, additional, Rouleau, Guy A., additional, Saito, Takeo, additional, Schall, Ulrich, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Scott, Laura J., additional, Scott, Rodney J., additional, Serretti, Alessandro, additional, Weickert, Cynthia Shannon, additional, Smoller, Jordan W., additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Streit, Fabian, additional, Sullivan, Patrick F., additional, Turecki, Gustavo, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Waldman, Irwin D., additional, Weickert, Thomas W., additional, Werge, Thomas, additional, Wray, Naomi R., additional, Zwart, John-Anker, additional, Biernacka, Joanna M., additional, Nurnberger, John I., additional, Cichon, Sven, additional, Edenberg, Howard J., additional, Stahl, Eli A., additional, McQuillin, Andrew, additional, Di Florio, Arianna, additional, Ophoff, Roel A., additional, and Andreassen, Ole A., additional

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2020
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127. Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme

Author

Bray, Michael J., primary, Chen, Li‐Shiun, additional, Fox, Louis, additional, Hancock, Dana B., additional, Culverhouse, Robert C., additional, Hartz, Sarah M., additional, Johnson, Eric O., additional, Liu, Mengzhen, additional, McKay, James D., additional, Saccone, Nancy L., additional, Hokanson, John E., additional, Vrieze, Scott I., additional, Tyndale, Rachel F., additional, Baker, Timothy B., additional, and Bierut, Laura J., additional

Published
2020
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128. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Author

Coleman, Jonathan R.I., primary, Gaspar, Héléna A., additional, Bryois, Julien, additional, Breen, Gerome, additional, Byrne, Enda M., additional, Forstner, Andreas J., additional, Holmans, Peter A., additional, de Leeuw, Christiaan A., additional, Mattheisen, Manuel, additional, McQuillin, Andrew, additional, Whitehead Pavlides, Jennifer M., additional, Pers, Tune H., additional, Ripke, Stephan, additional, Stahl, Eli A., additional, Steinberg, Stacy, additional, Trubetskoy, Vassily, additional, Trzaskowski, Maciej, additional, Wang, Yunpeng, additional, Abbott, Liam, additional, Abdellaoui, Abdel, additional, Adams, Mark J., additional, Adolfsson, Annelie Nordin, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D., additional, Andlauer, Till F.M., additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Van der Auwera, Sandra, additional, Awasthi, Swapnil, additional, Bacanu, Silviu-Alin, additional, Badner, Judith A., additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D., additional, Bass, Nicholas, additional, Bauer, Michael, additional, Beekman, Aartjan T.F., additional, Belliveau, Richard, additional, Bergen, Sarah E., additional, Bigdeli, Tim B., additional, Binder, Elisabeth B., additional, Bøen, Erlend, additional, Boks, Marco, additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Buttenschøn, Henriette N., additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cai, Na, additional, Casas, Miquel, additional, Castelao, Enrique, additional, Cerrato, Felecia, additional, Cervantes, Pablo, additional, Chambert, Kimberly, additional, Charney, Alexander W., additional, Chen, Danfeng, additional, Christensen, Jane Hvarregaard, additional, Churchhouse, Claire, additional, St Clair, David, additional, Clarke, Toni-Kim, additional, Colodro-Conde, Lucía, additional, Coryell, William, additional, Couvy-Duchesne, Baptiste, additional, Craig, David W., additional, Crawford, Gregory E., additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Davies, Gail, additional, Deary, Ian J., additional, Degenhardt, Franziska, additional, Del-Favero, Jurgen, additional, DePaulo, J Raymond, additional, Derks, Eske M., additional, Direk, Nese, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Dolan, Conor V., additional, Dumont, Ashley, additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Fan, Chun Chieh, additional, Finucane, Hilary K., additional, Fischer, Sascha B., additional, Flickinger, Matthew, additional, Foo, Jerome C., additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Fraser, Christine, additional, Freimer, Nelson B., additional, Frisén, Louise, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Goes, Fernando S., additional, Goldstein, Jaqueline, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grove, Jakob, additional, Guan, Weihua, additional, Hall, Lynsey S., additional, Hamshere, Marian L., additional, Hansen, Christine Søholm, additional, Hansen, Thomas F., additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, van Hemert, Albert M., additional, Herms, Stefan, additional, Hickie, Ian B., additional, Hipolito, Maria, additional, Hoffmann, Per, additional, Holland, Dominic, additional, Homuth, Georg, additional, Horn, Carsten, additional, Hottenga, Jouke-Jan, additional, Huckins, Laura, additional, Ising, Marcus, additional, Jamain, Stéphane, additional, Jansen, Rick, additional, Johnson, Jessica S., additional, de Jong, Simone, additional, Jorgenson, Eric, additional, Juréus, Anders, additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kennedy, James L., additional, Hassan Kiadeh, Farnush Farhadi, additional, Kittel-Schneider, Sarah, additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Kohane, Isaac S., additional, Koller, Anna C., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Krogh, Jesper, additional, Kupka, Ralph, additional, Kutalik, Zoltán, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B., additional, Leber, Markus, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Li, Jun Z., additional, Li, Yihan, additional, Lind, Penelope A., additional, Liu, Chunyu, additional, Olde Loohuis, Loes M., additional, Maaser, Anna, additional, MacIntyre, Donald J., additional, MacKinnon, Dean F., additional, Mahon, Pamela B., additional, Maier, Wolfgang, additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Martinsson, Lina, additional, Mbarek, Hamdi, additional, McCarroll, Steve, additional, McGrath, Patrick, additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Mehta, Divya, additional, Meng, Fan, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Milaneschi, Yuri, additional, Milani, Lili, additional, Mirza, Saira Saeed, additional, Mondimore, Francis M., additional, Montgomery, Grant W., additional, Morris, Derek W., additional, Mostafavi, Sara, additional, Mühleisen, Thomas W., additional, Mullins, Niamh, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nguyen, Hoang, additional, Nievergelt, Caroline M., additional, Nivard, Michel G., additional, Nwulia, Evaristus A., additional, Nyholt, Dale R., additional, O'Donovan, Claire, additional, O'Reilly, Paul F., additional, Ori, Anil P.S., additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Oskarsson, Hogni, additional, Painter, Jodie N., additional, Parra, José Guzman, additional, Pedersen, Carsten Bøcker, additional, Pedersen, Marianne Giørtz, additional, Perry, Amy, additional, Peterson, Roseann E., additional, Pettersson, Erik, additional, Peyrot, Wouter J., additional, Pfennig, Andrea, additional, Pistis, Giorgio, additional, Purcell, Shaun M., additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Regeer, Eline J., additional, Reif, Andreas, additional, Reinbold, Céline S., additional, Rice, John P., additional, Riley, Brien P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schoevers, Robert, additional, Schork, Nicholas J., additional, Schulte, Eva C., additional, Shehktman, Tatyana, additional, Shen, Ling, additional, Shi, Jianxin, additional, Shilling, Paul D., additional, Shyn, Stanley I., additional, Sigurdsson, Engilbert, additional, Slaney, Claire, additional, Smeland, Olav B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Sobell, Janet L., additional, Spijker, Anne T., additional, Steffens, Michael, additional, Strauss, John S., additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Szelinger, Szabolcs, additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Teumer, Alexander, additional, Thompson, Robert C., additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Thorgeirsson, Thorgeir E., additional, Traylor, Matthew, additional, Treutlein, Jens, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, Vedder, Helmut, additional, Viktorin, Alexander, additional, Visscher, Peter M., additional, Wang, Weiqing, additional, Watson, Stanley J., additional, Webb, Bradley T., additional, Weickert, Cynthia Shannon, additional, Weickert, Thomas W., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Willemsen, Gonneke, additional, Witt, Stephanie H., additional, Wu, Yang, additional, Xi, Hualin S., additional, Xu, Wei, additional, Yang, Jian, additional, Young, Allan H., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zhang, Futao, additional, Zollner, Sebastian, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Arolt, Volker, additional, Backlund, Lena, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Berger, Klaus, additional, Berrettini, Wade H., additional, Biernacka, Joanna M., additional, Blackwood, Douglas H.R., additional, Boehnke, Michael, additional, Boomsma, Dorret I., additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Daly, Mark J., additional, Dannlowski, Udo, additional, Domenici, Enrico, additional, Domschke, Katharina, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gershon, Elliot S., additional, de Geus, E.J.C., additional, Gill, Michael, additional, Goes, Fernando, additional, Grabe, Hans J., additional, Grigoroiu-Serbanescu, Maria, additional, Hamilton, Steven P., additional, Hauser, Joanna, additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Hougaard, David M., additional, Hultman, Christina M., additional, Jones, Ian, additional, Jones, Lisa A., additional, Kahn, René S., additional, Kendler, Kenneth S., additional, Kirov, George, additional, Kloiber, Stefan, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Glyn, additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Lucae, Susanne, additional, Madden, Pamela A.F., additional, Magnusson, Patrik K., additional, Martin, Nicholas G., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, Melle, Ingrid, additional, Metspalu, Andres, additional, Mitchell, Philip B., additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M., additional, Neale, Benjamin M., additional, Nimgaonkar, Vishwajit, additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O'Donovan, Michael C., additional, Oedegaard, Ketil J., additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pato, Carlos, additional, Pato, Michele T., additional, Pedersen, Nancy L., additional, Penninx, Brenda W.J. H., additional, Perlis, Roy H., additional, Porteous, David J., additional, Posthuma, Danielle, additional, Potash, James B., additional, Preisig, Martin, additional, Ramos-Quiroga, Josep Antoni, additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Rouleau, Guy A., additional, Schaefer, Catherine, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Serretti, Alessandro, additional, Smoller, Jordan W., additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Tiemeier, Henning, additional, Turecki, Gustavo, additional, Uher, Rudolf, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Völzke, Henry, additional, Weissman, Myrna M., additional, Werge, Thomas, additional, Andreassen, Ole A., additional, Børglum, Anders D., additional, Cichon, Sven, additional, Edenberg, Howard J., additional, Di Florio, Arianna, additional, Kelsoe, John, additional, Levinson, Douglas F., additional, Lewis, Cathryn M., additional, Nurnberger, John I., additional, Ophoff, Roel A., additional, Scott, Laura J., additional, Sklar, Pamela, additional, Sullivan, Patrick F., additional, and Wray, Naomi R., additional

Published
2020
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129. Lipid Trait Variants and the Risk of Non-Hodgkin Lymphoma Subtypes: A Mendelian Randomization Study

Author

Kleinstern, Geffen, primary, Camp, Nicola J., additional, Berndt, Sonja I., additional, Birmann, Brenda M., additional, Nieters, Alexandra, additional, Bracci, Paige M., additional, McKay, James D., additional, Ghesquières, Hervé, additional, Lan, Qing, additional, Hjalgrim, Henrik, additional, Benavente, Yolanda, additional, Monnereau, Alain, additional, Wang, Sophia S., additional, Zhang, Yawei, additional, Purdue, Mark P., additional, Zeleniuch-Jacquotte, Anne, additional, Giles, Graham G., additional, Vermeulen, Roel, additional, Cocco, Pierluigi, additional, Albanes, Demetrius, additional, Teras, Lauren R., additional, Brooks-Wilson, Angela R., additional, Vajdic, Claire M., additional, Kane, Eleanor, additional, Caporaso, Neil E., additional, Smedby, Karin E., additional, Salles, Gilles, additional, Vijai, Joseph, additional, Chanock, Stephen J., additional, Skibola, Christine F., additional, Rothman, Nathaniel, additional, Slager, Susan L., additional, and Cerhan, James R., additional

Published
2020
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130. Needlestack: an ultra-sensitive variant caller for multi-sample next generation sequencing data

Author

Delhomme, Tiffany M, primary, Avogbe, Patrice H, additional, Gabriel, Aurélie A G, additional, Alcala, Nicolas, additional, Leblay, Noemie, additional, Voegele, Catherine, additional, Vallée, Maxime, additional, Chopard, Priscilia, additional, Chabrier, Amélie, additional, Abedi-Ardekani, Behnoush, additional, Gaborieau, Valérie, additional, Holcatova, Ivana, additional, Janout, Vladimir, additional, Foretová, Lenka, additional, Milosavljevic, Sasa, additional, Zaridze, David, additional, Mukeriya, Anush, additional, Brambilla, Elisabeth, additional, Brennan, Paul, additional, Scelo, Ghislaine, additional, Fernandez-Cuesta, Lynnette, additional, Byrnes, Graham, additional, Calvez-Kelm, Florence L, additional, McKay, James D, additional, and Foll, Matthieu, additional

Published
2020
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131. Replication of Lung Cancer Susceptibility Loci at Chromosomes 15q25, 5p15, and 6p21: A Pooled Analysis From the International Lung Cancer Consortium

Author

Truong, Therese, Hung, Rayjean J., Amos, Christopher I., Wu, Xifeng, Bickeböller, Heike, Rosenberger, Albert, Sauter, Wiebke, Illig, Thomas, Wichmann, H.-Erich, Risch, Angela, Dienemann, Hendrik, Kaaks, Rudolph, Yang, Ping, Jiang, Ruoxiang, Wiencke, John K., Wrensch, Margaret, Hansen, Helen, Kelsey, Karl T., Matsuo, Keitaro, Tajima, Kazuo, Schwartz, Ann G., Wenzlaff, Angie, Seow, Adeline, Ying, Chen, Staratschek-Jox, Andrea, Nürnberg, Peter, Stoelben, Erich, Wolf, Jürgen, Lazarus, Philip, Muscat, Joshua E., Gallagher, Carla J., Zienolddiny, Shanbeh, Haugen, Aage, van der Heijden, Henricus F., Kiemeney, Lambertus A., Isla, Dolores, Mayordomo, Jose Ignacio, Rafnar, Thorunn, Stefansson, Kari, Zhang, Zuo-Feng, Chang, Shen-Chih, Kim, Jin Hee, Hong, Yun-Chul, Duell, Eric J., Andrew, Angeline S., Lejbkowicz, Flavio, Rennert, Gad, Müller, Heiko, Brenner, Hermann, Le Marchand, Loïc, Benhamou, Simone, Bouchardy, Christine, Teare, M. Dawn, Xue, Xiaoyan, McLaughlin, John, Liu, Geoffrey, McKay, James D., Brennan, Paul, and Spitz, Margaret R.

Published
2010
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132. Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

Author

Lips, Esther H, Gaborieau, Valerie, McKay, James D, Chabrier, Amelie, Hung, Rayjean J, Boffetta, Paolo, Hashibe, Mia, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Field, John K, Liloglou, Triantafillos, Xinarianos, George, McLaughlin, John, Liu, Geoffrey, Skorpen, Frank, Elvestad, Maiken Bratt, Hveem, Kristian, Vatten, Lars, Study, EPIC, Benhamou, Simone, Lagiou, Pagona, Holcátová, Ivana, Merletti, Franco, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V, Barzan, Luigi, Canova, Cristina, Lowry, Ray, Conway, David I, Znaor, Ariana, Healy, Claire, Curado, Maria Paula, Koifman, Sergio, Eluf-Neto, Jose, Matos, Elena, Menezes, Ana, Fernandez, Leticia, Metspalu, Andres, Heath, Simon, Lathrop, Mark, and Brennan, Paul

Published
2010
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133. International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants

Author

Truong, Therese, Sauter, Wiebke, McKay, James D., Hosgood, H.Dean, III, Gallagher, Carla, Amos, Christopher I., Spitz, Margaret, Muscat, Joshua, Lazarus, Philip, Illig, Thomas, Wichmann, H.Erich, Bickeböller, Heike, Risch, Angela, Dienemann, Hendrik, Zhang, Zuo-Feng, Naeim, Behnaz Pezeshki, Yang, Ping, Zienolddiny, Shanbeh, Haugen, Aage, Le Marchand, Loïc, Hong, Yun-Chul, Kim, Jin Hee, Duell, Eric J., Andrew, Angeline S., Kiyohara, Chikako, Shen, Hongbing, Matsuo, Keitaro, Suzuki, Takeshi, Seow, Adeline, Ng, Daniel P.K., Lan, Qing, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Constantinescu, Vali, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Caporaso, Neil E., Albanes, Demetrius, Thun, Michael, Landi, Maria Teresa, Trubicka, Joanna, Lener, Marcin, Lubiński, Jan, Wang, Ying, Chabrier, Amélie, Boffetta, Paolo, Brennan, Paul, and Hung, Rayjean J.

Published
2010
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138. Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Dossus, Laure, McKay, James D., Canzian, Federico, Wilkening, Stefan, Rinaldi, Sabina, Biessy, Carine, Olsen, Anja, Tjønneland, Anne, Jakobsen, Marianne U., Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Fournier, Agnes, Linseisen, Jakob, Lukanova, Annekatrin, Boeing, Heiner, Fisher, Eva, Trichopoulou, Antonia, Georgila, Christina, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Vineis, Paolo, Quirós, José Ramon, Sala, Núria, Martínez-García, Carmen, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte, Aurelio, van Duijnhoven, Fränzel J.B., Bueno-de-Mesquita, H.B., van Gils, Carla H., Peeters, Petra H.M., Hallmans, Göran, Lenner, Per, Bingham, Sheila, Khaw, Kay Tee, Key, Tim J., Travis, Ruth C., Ferrari, Pietro, Jenab, Mazda, Riboli, Elio, and Kaaks, Rudolf

Published
2008

139. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Author

Hung, Rayjean J., McKay, James D., Gaborieau, Valerie, Boffetta, Paolo, Hashibe, Mia, Zaridze, David, Mukeria, Anush, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Chen, Chu, Goodman, Gary, Field, John K., Liloglou, Triantafillos, Xinarianos, George, Cassidy, Adrian, McLaughlin, John, Liu, Geoffrey, Narod, Steven, Krokan, Hans E., Skorpen, Frank, Elvestad, Maiken Bratt, Hveem, Kristian, Vatten, Lars, Linseisen, Jakob, Clavel-Chapelon, Françoise, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Lund, Eiliv, Martinez, Carmen, Bingham, Sheila, Rasmuson, Torgny, Hainaut, Pierre, Riboli, Elio, Ahrens, Wolfgang, Benhamou, Simone, Lagiou, Pagona, Trichopoulos, Dimitrios, Holcátová, Ivana, Merletti, Franco, Kjaerheim, Kristina, Agudo, Antonio, Macfarlane, Gary, Talamini, Renato, Simonato, Lorenzo, Lowry, Ray, Conway, David I., Znaor, Ariana, Healy, Claire, Zelenika, Diana, Boland, Anne, Delepine, Marc, Foglio, Mario, Lechner, Doris, Matsuda, Fumihiko, Blanche, Helene, Gut, Ivo, Heath, Simon, Lathrop, Mark, and Brennan, Paul

Published
2008
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140. Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population

Author

Musliner, Katherine L., Mortensen, Preben B., McGrath, John J., Suppli, Nis P., Hougaard, David M., Bybjerg-Grauholm, Jonas, Baekvad-Hansen, Marie, Andreassen, Ole, Pedersen, Carsten B., Pedersen, Marianne G., Mors, Ole, Nordentoft, Merete, Borglum, Anders D., Werge, Thomas, Agerbo, Esben, Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R., I, Gaspar, Helena A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Pers, Tune H., Holmans, Peter A., Abbott, Liam, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Etzekvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bocker, Boen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Byerley, William, Casas, Miguel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Chamey, Alexander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders M., de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsashagen, Torbjorn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisen, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartobmei, Claudia, Pedersen, Marianne Giortz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Parra, Jose Guzman, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stephan, Johnson, Jessica S., Jureus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knott, Sarah, V, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Muehleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P. S., Oruc, Lilijana, Osby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Celine S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sanchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Soholm, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E., Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Agartz, Ingrid, Aida, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biemacka, Joanna M., Blackwood, Douglas H. R., Boehnke, Michael, Berglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tonu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, Rene S., Kirov, George, Landen, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Noethen, Markus M., O'Donovan, Michael C., Oedegaard, Ketil J., Owen, Michael, Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribases, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne E., Ieta, Eduard, V, Vincent, John B., Nurnberger, John, I, Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole A., Kelsoe, John, Sklar, Pamela, and Psychiat Genomics Consortium

Subjects
Adult, Male, medicine.medical_specialty, Multifactorial Inheritance, Bipolar Disorder, Adolescent, Denmark, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, medicine, Journal Article, Humans, Genetic Predisposition to Disease, Bipolar disorder, Young adult, Association (psychology), Psychiatry, Child, Depression (differential diagnoses), Proportional Hazards Models, Depressive Disorder, Major, Proportional hazards model, business.industry, Depression, Case-control study, Age Factors, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Case-Control Studies, Linear Models, Major depressive disorder, Female, Human medicine, business, 030217 neurology & neurosurgery
Abstract

Importance: Although the usefulness of polygenic risk scores as a measure of genetic liability for major depression (MD) has been established, their association with depression in the general population remains relatively unexplored.Objective: To evaluate whether polygenic risk scores for MD, bipolar disorder (BD), and schizophrenia (SZ) are associated with depression in the general population and explore whether these polygenic liabilities are associated with heterogeneity in terms of age at onset and severity at the initial depression diagnosis.Design, Setting, and Participants: Participants were drawn from the Danish iPSYCH2012 case-cohort study, a representative sample drawn from the population of Denmark born between May 1, 1981, and December 31, 2005. The hazard of depression was estimated using Cox regressions modified to accommodate the case-cohort design. Case-only analyses were conducted using linear and multinomial regressions. The data analysis was conducted from February 2017 to June 2018.Exposures: Polygenic risk scores for MD, BD, and SZ trained using the most recent genome-wide association study results from the Psychiatric Genomics Consortium.Main Outcomes and Measures: The main outcome was first depressive episode (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] code F32) treated in hospital-based psychiatric care. Severity at the initial diagnosis was measured using the ICD-10 code severity specifications (mild, moderate, severe without psychosis, and severe with psychosis) and treatment setting (inpatient, outpatient, and emergency).Results: Of 34 573 participants aged 10 to 31 years at censoring, 68% of those with depression were female compared with 48.9% of participants without depression. Each SD increase in polygenic liability for MD, BD, and SZ was associated with 30% (hazard ratio [HR], 1.30; 95% CI, 1.27-1.33), 5% (HR, 1.05; 95% CI, 1.02-1.07), and 12% (HR, 1.12; 95% CI, 1.09-1.15) increases in the hazard of depression, respectively. Among cases, a higher polygenic liability for BD was associated with earlier depression onset (β = -.07; SE = .02; P = .002).Conclusions and Relevance: Polygenic liability for MD is associated with first depression in the general population, which supports the idea that these scores tap into an underlying liability for developing the disorder. The fact that polygenic risk for BD and polygenic risk for SZ also were associated with depression is consistent with prior evidence that these disorders share some common genetic overlap. Variations in polygenic liability may contribute slightly to heterogeneity in clinical presentation, but these associations appear minimal.

Published
2019
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141. Genome-wide association study identifies 30 loci associated with bipolar disorder

Author

Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco P., Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alxander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders, de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, Depaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tifany A., Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Shannon Weickert, Cynthia, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav Bjerkehagen, Sobell, Janet L., Søholm Hansen, Christine, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E, Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zöllner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M., Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, René S., Kirov, George, Landén, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C, Ødegaard, Ketil Joachim, Owen, Michael J., Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne, Vieta, Eduard, Vincent, John B., Werge, Thomas, Nurnberger, John I., Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole Andreas, Kelsoe, John, and Sklar, Pamela

Abstract

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P

Published
2019

145. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development

Author

Li, Yafang, Xiao, Xiangjun, Bossé, Yohan, Gorlova, Olga, Gorlov, Ivan, Han, Younghun, Byun, Jinyoung, Leighl, Natasha, Johansen, Jakob S., Barnett, Matt, Chen, Chu, Goodman, Gary, Cox, Angela, Taylor, Fiona, Woll, Penella, Wichmann, H. Erich, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Han, Jiali, Siminovitch, Katherine, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Houlston, Richard, Artigas, María Soler, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Liu, Geoffrey, Bojesen, Stig E., Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Bertazzi, Pier Alberto, Pesatori, Angela C., Christiani, David C., Caporaso, Neil, Johansson, Mattias, McKay, James D., Brennan, Paul, Hung, Rayjean J., Amos, Christopher I., Li, Yafang, Xiao, Xiangjun, Bossé, Yohan, Gorlova, Olga, Gorlov, Ivan, Han, Younghun, Byun, Jinyoung, Leighl, Natasha, Johansen, Jakob S., Barnett, Matt, Chen, Chu, Goodman, Gary, Cox, Angela, Taylor, Fiona, Woll, Penella, Wichmann, H. Erich, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Han, Jiali, Siminovitch, Katherine, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Houlston, Richard, Artigas, María Soler, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Liu, Geoffrey, Bojesen, Stig E., Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Bertazzi, Pier Alberto, Pesatori, Angela C., Christiani, David C., Caporaso, Neil, Johansson, Mattias, McKay, James D., Brennan, Paul, Hung, Rayjean J., and Amos, Christopher I.

Abstract

The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions between SNPs in RGL1:RAD51B (OR=0.44, p value=3.27x10-11 in overall lung cancer and OR=0.41, p value=9.71x10-11 in non-small cell lung cancer), SYNE1:RNF43 (OR=0.73, p value=1.01x10-12 in adenocarcinoma) and FHIT:TSPAN8 (OR=1.82, p value=7.62x10-11 in squamous cell carcinoma) in our analysis. None of these genes have been identified from previous main effect association studies in lung cancer. Further eQTL gene expression analysis in lung tissues provided information supporting the functional role of the identified epistasis in lung tumorigenesis. Gene set enrichment analysis revealed potential pathways and gene networks underlying molecular mechanisms in overall lung cancer as well as histology subtypes development. Our results provide evidence that genetic interactions between oncogenesis-related genes play an important role in lung tumorigenesis and epistasis analysis, combined with functional annotation, provides a valuable tool for uncovering functional novel susceptibility genes that contribute to lung cancer development by interacting with other modifier genes.

Published
2019
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146. Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci

Author

Dai, Juncheng, Li, Zhihua, Amos, Christopher I., Hung, Rayjean J., Tardon, Adonina, Andrew, Angeline S., Chen, Chu, Christiani, David C., Albanes, Demetrios, van der Heijden, Erik H. F. M., Duell, Eric J., Rennert, Gad, Mckay, James D., Yuan, Jian-Min, Field, John K., Manjer, Jonas, Grankvist, Kjell, Le Marchand, Loic, Teare, M. Dawn, Schabath, Matthew B., Aldrich, Melinda C., Tsao, Ming-Sound, Lazarus, Philip, Lam, Stephen, Bojesen, Stig E., Arnold, Susanne, Wu, Xifeng, Haugen, Aage, Janout, Vladimir, Johansson, Mikael, Brhane, Yonathan, Fernandez-Somoano, Ana, Kiemeney, Lambertus A., Davies, Michael P. A., Zienolddiny, Shanbeh, Hu, Zhibin, Shen, Hongbing, Dai, Juncheng, Li, Zhihua, Amos, Christopher I., Hung, Rayjean J., Tardon, Adonina, Andrew, Angeline S., Chen, Chu, Christiani, David C., Albanes, Demetrios, van der Heijden, Erik H. F. M., Duell, Eric J., Rennert, Gad, Mckay, James D., Yuan, Jian-Min, Field, John K., Manjer, Jonas, Grankvist, Kjell, Le Marchand, Loic, Teare, M. Dawn, Schabath, Matthew B., Aldrich, Melinda C., Tsao, Ming-Sound, Lazarus, Philip, Lam, Stephen, Bojesen, Stig E., Arnold, Susanne, Wu, Xifeng, Haugen, Aage, Janout, Vladimir, Johansson, Mikael, Brhane, Yonathan, Fernandez-Somoano, Ana, Kiemeney, Lambertus A., Davies, Michael P. A., Zienolddiny, Shanbeh, Hu, Zhibin, and Shen, Hongbing

Abstract

DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-related variants in lung cancer. In this study, we performed a large-scale case-control study with 20 871 lung cancer cases and 15 971 controls to evaluate the associations between regulatory genetic variants in DHS and lung cancer susceptibility. The expression quantitative trait loci (eQTL) analysis and pathway-enrichment analysis were performed to identify the possible target genes and pathways. In addition, we performed motif-based analysis to explore the lung-cancer-related motifs using sequence kernel association test. Two novel variants, rs186332 in 20q13.3 (C>T, odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.10-1.24, P = 8.45 x 10(-7)) and rs4839323 in 1p13.2 (T>C, OR = 0.92, 95% CI: 0.89-0.95, P = 1.02 x 10(-6)) showed significant association with lung cancer risk. The eQTL analysis suggested that these two SNPs might regulate the expression of MRGBP and SLC16A1, respectively. What's more, the expression of both MRGBP and SLC16A1 was aberrantly elevated in lung tumor tissues. The motif-based analysis identified 10 motifs related to the risk of lung cancer (P < 1.71 x 10(-4)). Our findings suggested that variants in DHS might modify lung cancer susceptibility through regulating the expression of surrounding genes. This study provided us a deeper insight into the roles of DHS-related genetic variants for lung cancer.

Published
2019
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147. Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer : A Mendelian Randomization Analysis

Author

Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming-Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, Mckay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz-Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P. A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., van der Heijden, Erik H. F. M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, Christiani, David C., Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming-Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, Mckay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz-Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P. A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., van der Heijden, Erik H. F. M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, and Christiani, David C.

Abstract

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Published
2019
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148. Sex specific associations in genome wide association analysis of renal cell carcinoma

Author

Laskar, Ruhina S, Muller, David C, Li, Peng, Machiela, Mitchell J, Ye, Yuanqing, Gaborieau, Valerie, Foll, Matthieu, Hofmann, Jonathan N, Colli, Leandro, Sampson, Joshua N, Wang, Zhaoming, Bacq-Daian, Delphine, Boland, Anne, Abedi-Ardekani, Behnoush, Durand, Geoffroy, Le Calvez-Kelm, Florence, Robinot, Nivonirina, Blanche, Helene, Prokhortchouk, Egor, Skryabin, Konstantin G, Burdett, Laurie, Yeager, Meredith, Radojevic-Skodric, Sanja, Savic, Slavisa, Foretova, Lenka, Holcatova, Ivana, Janout, Vladimir, Mates, Dana, Rascu, Stefan, Mukeria, Anush, Zaridze, David, Bencko, Vladimir, Cybulski, Cezary, Fabianova, Eleonora, Jinga, Viorel, Lissowska, Jolanta, Lubinski, Jan, Navratilova, Marie, Rudnai, Peter, Świątkowska, Beata, Benhamou, Simone, Cancel-Tassin, Geraldine, Cussenot, Olivier, Trichopoulou, Antonia, Riboli, Elio, Overvad, Kim, Panico, Salvatore, Ljungberg, Börje, Tumkur Sitaram, Raviprakash, Giles, Graham G, Milne, Roger L, Severi, Gianluca, Bruinsma, Fiona, Fletcher, Tony, Koppova, Kvetoslava, Larsson, Susanna C, Wolk, Alicja, Banks, Rosamonde E, Selby, Peter J, Easton, Douglas F, Pharoah, Paul, Andreotti, Gabriella, Beane Freeman, Laura E, Koutros, Stella, Albanes, Demetrius, Männistö, Satu, Weinstein, Stephanie, Clark, Peter E, Edwards, Todd L, Lipworth, Loren, Carol, Hallie, Freedman, Matthew L, Pomerantz, Mark M, Cho, Eunyoung, Kraft, Peter, Preston, Mark A, Wilson, Kathryn M, Michael Gaziano, J, Sesso, Howard D, Black, Amanda, Freedman, Neal D, Huang, Wen-Yi, Anema, John G, Kahnoski, Richard J, Lane, Brian R, Noyes, Sabrina L, Petillo, David, Teh, Bin Tean, Peters, Ulrike, White, Emily, Anderson, Garnet L, Johnson, Lisa, Luo, Juhua, Chow, Wong-Ho, Moore, Lee E, Choueiri, Toni K, Wood, Christopher, Johansson, Mattias, McKay, James D, Brown, Kevin M, Rothman, Nathaniel, Lathrop, Mark G, Deleuze, Jean-Francois, Wu, Xifeng, Brennan, Paul, Chanock, Stephen J, Purdue, Mark P, Scelo, Ghislaine, Laskar, Ruhina S, Muller, David C, Li, Peng, Machiela, Mitchell J, Ye, Yuanqing, Gaborieau, Valerie, Foll, Matthieu, Hofmann, Jonathan N, Colli, Leandro, Sampson, Joshua N, Wang, Zhaoming, Bacq-Daian, Delphine, Boland, Anne, Abedi-Ardekani, Behnoush, Durand, Geoffroy, Le Calvez-Kelm, Florence, Robinot, Nivonirina, Blanche, Helene, Prokhortchouk, Egor, Skryabin, Konstantin G, Burdett, Laurie, Yeager, Meredith, Radojevic-Skodric, Sanja, Savic, Slavisa, Foretova, Lenka, Holcatova, Ivana, Janout, Vladimir, Mates, Dana, Rascu, Stefan, Mukeria, Anush, Zaridze, David, Bencko, Vladimir, Cybulski, Cezary, Fabianova, Eleonora, Jinga, Viorel, Lissowska, Jolanta, Lubinski, Jan, Navratilova, Marie, Rudnai, Peter, Świątkowska, Beata, Benhamou, Simone, Cancel-Tassin, Geraldine, Cussenot, Olivier, Trichopoulou, Antonia, Riboli, Elio, Overvad, Kim, Panico, Salvatore, Ljungberg, Börje, Tumkur Sitaram, Raviprakash, Giles, Graham G, Milne, Roger L, Severi, Gianluca, Bruinsma, Fiona, Fletcher, Tony, Koppova, Kvetoslava, Larsson, Susanna C, Wolk, Alicja, Banks, Rosamonde E, Selby, Peter J, Easton, Douglas F, Pharoah, Paul, Andreotti, Gabriella, Beane Freeman, Laura E, Koutros, Stella, Albanes, Demetrius, Männistö, Satu, Weinstein, Stephanie, Clark, Peter E, Edwards, Todd L, Lipworth, Loren, Carol, Hallie, Freedman, Matthew L, Pomerantz, Mark M, Cho, Eunyoung, Kraft, Peter, Preston, Mark A, Wilson, Kathryn M, Michael Gaziano, J, Sesso, Howard D, Black, Amanda, Freedman, Neal D, Huang, Wen-Yi, Anema, John G, Kahnoski, Richard J, Lane, Brian R, Noyes, Sabrina L, Petillo, David, Teh, Bin Tean, Peters, Ulrike, White, Emily, Anderson, Garnet L, Johnson, Lisa, Luo, Juhua, Chow, Wong-Ho, Moore, Lee E, Choueiri, Toni K, Wood, Christopher, Johansson, Mattias, McKay, James D, Brown, Kevin M, Rothman, Nathaniel, Lathrop, Mark G, Deleuze, Jean-Francois, Wu, Xifeng, Brennan, Paul, Chanock, Stephen J, Purdue, Mark P, and Scelo, Ghislaine

Abstract

Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.

Published
2019
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149. Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Pertesi, Maroulio, Vallée, Maxime, Wei, Xiaomu, Revuelta, Maria V, Galia, Perrine, Demangel, Delphine, Oliver, Javier, Foll, Matthieu, Chen, Siwei, Perrial, Emeline, Garderet, Laurent, Corre, Jill, Leleu, Xavier, Boyle, Eileen M, Decaux, Olivier, Rodon, Philippe, Kolb, Brigitte, Slama, Borhane, Mineur, Philippe, Voog, Eric, Le Bris, Catherine, Fontan, Jean, Maigre, Michel, Beaumont, Marie, Azais, Isabelle, Sobol, Hagay, Vignon, Marguerite, Royer, Bruno, Perrot, Aurore, Fuzibet, Jean-Gabriel, Dorvaux, Véronique, Anglaret, Bruno, Cony-Makhoul, Pascale, Berthou, Christian, Desquesnes, Florence, Pegourie, Brigitte, Leyvraz, Serge, Mosser, Laurent, Frenkiel, Nicole, Augeul-Meunier, Karine, Leduc, Isabelle, Leyronnas, Cécile, Voillat, Laurent, Casassus, Philippe, Mathiot, Claire, Cheron, Nathalie, Paubelle, Etienne, Moreau, Philippe, Bignon, Yves-Jean, Joly, Bertrand, Bourquard, Pascal, Caillot, Denis, Naman, Hervé, Rigaudeau, Sophie, Marit, Gérald, Macro, Margaret, Lambrecht, Isabelle, Cliquennois, Manuel, Vincent, Laure, Helias, Philippe, Avet-Loiseau, Hervé, Moreno, Victor, Reis, Rui Manuel, Varkonyi, Judit, Kruszewski, Marcin, Vangsted, Annette Juul, Jurczyszyn, Artur, Zaucha, Jan Maciej, Sainz, Juan, Krawczyk-Kulis, Malgorzata, Wątek, Marzena, Pelosini, Matteo, Iskierka-Jażdżewska, Elzbieta, Grząśko, Norbert, Martinez-Lopez, Joaquin, Jerez, Andrés, Campa, Daniele, Buda, Gabriele, Lesueur, Fabienne, Dudziński, Marek, García-Sanz, Ramón, Nagler, Arnon, Rymko, Marcin, Jamroziak, Krzysztof, Butrym, Aleksandra, Canzian, Federico, Obazee, Ofure, Nilsson, Björn, Klein, Robert J, Lipkin, Steven M, McKay, James D, Dumontet, Charles, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Pertesi, Maroulio, Vallée, Maxime, Wei, Xiaomu, Revuelta, Maria V, Galia, Perrine, Demangel, Delphine, Oliver, Javier, Foll, Matthieu, Chen, Siwei, Perrial, Emeline, Garderet, Laurent, Corre, Jill, Leleu, Xavier, Boyle, Eileen M, Decaux, Olivier, Rodon, Philippe, Kolb, Brigitte, Slama, Borhane, Mineur, Philippe, Voog, Eric, Le Bris, Catherine, Fontan, Jean, Maigre, Michel, Beaumont, Marie, Azais, Isabelle, Sobol, Hagay, Vignon, Marguerite, Royer, Bruno, Perrot, Aurore, Fuzibet, Jean-Gabriel, Dorvaux, Véronique, Anglaret, Bruno, Cony-Makhoul, Pascale, Berthou, Christian, Desquesnes, Florence, Pegourie, Brigitte, Leyvraz, Serge, Mosser, Laurent, Frenkiel, Nicole, Augeul-Meunier, Karine, Leduc, Isabelle, Leyronnas, Cécile, Voillat, Laurent, Casassus, Philippe, Mathiot, Claire, Cheron, Nathalie, Paubelle, Etienne, Moreau, Philippe, Bignon, Yves-Jean, Joly, Bertrand, Bourquard, Pascal, Caillot, Denis, Naman, Hervé, Rigaudeau, Sophie, Marit, Gérald, Macro, Margaret, Lambrecht, Isabelle, Cliquennois, Manuel, Vincent, Laure, Helias, Philippe, Avet-Loiseau, Hervé, Moreno, Victor, Reis, Rui Manuel, Varkonyi, Judit, Kruszewski, Marcin, Vangsted, Annette Juul, Jurczyszyn, Artur, Zaucha, Jan Maciej, Sainz, Juan, Krawczyk-Kulis, Malgorzata, Wątek, Marzena, Pelosini, Matteo, Iskierka-Jażdżewska, Elzbieta, Grząśko, Norbert, Martinez-Lopez, Joaquin, Jerez, Andrés, Campa, Daniele, Buda, Gabriele, Lesueur, Fabienne, Dudziński, Marek, García-Sanz, Ramón, Nagler, Arnon, Rymko, Marcin, Jamroziak, Krzysztof, Butrym, Aleksandra, Canzian, Federico, Obazee, Ofure, Nilsson, Björn, Klein, Robert J, Lipkin, Steven M, McKay, James D, and Dumontet, Charles

Abstract

To the Editor, Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS) [1], and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM [...]

Published
2019

150. Elevated platelet count appears to be causally associated with increased risk of lung cancer:A mendelian randomization analysis

Author

Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, McKay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P.A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., Van der Heijden, Erik H.F.M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, Christiani, David C., Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, McKay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P.A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., Van der Heijden, Erik H.F.M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, and Christiani, David C.

Abstract

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non–small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15–2.27; P ¼ 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27–7.06; P ¼ 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Published
2019

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