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892 results on '"McBride, C"'

102. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: modelling of the luminosity and colour dependence in the Data Release 10

Author

Guo, H., primary, Zheng, Z., additional, Zehavi, I., additional, Xu, H., additional, Eisenstein, D. J., additional, Weinberg, D. H., additional, Bahcall, N. A., additional, Berlind, A. A., additional, Comparat, J., additional, McBride, C. K., additional, Ross, A. J., additional, Schneider, D. P., additional, Skibba, R. A., additional, Swanson, M. E. C., additional, Tinker, J. L., additional, Tojeiro, R., additional, and Wake, D. A., additional

Published
2014
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103. The effect of neighborhood-based community organizing: results from the Seattle Minority Youth Health Project

Author

Cheadle, A, Wagner, E, Walls, M, Diehr, P, Bell, M, Anderman, C, McBride, C, Catalano, R F, Pettigrew, E, Simmons, R, and Neckerman, H

Subjects
Adult, Washington, Adolescent, Substance-Related Disorders, Sexual Behavior, Community Participation, Health Promotion, Violence, Community Health Planning, Residence Characteristics, Surveys and Questionnaires, Humans, Health Services Research, Minority Groups, Research Article, Program Evaluation
Abstract

OBJECTIVE: To evaluate the effect of a community mobilization and youth development strategy to prevent drug abuse, violence, and risky sexual activity. DATA SOURCES/STUDY SETTING: Primary surveys of youth, parents, and key neighborhood leaders were carried out at baseline (1994) and at the end of the intervention period (1997). The study took place in four intervention and six control neighborhoods in Seattle. STUDY DESIGN: The study was designed as a randomized controlled trial with neighborhood as the unit of randomization. The intervention consisted of a paid community organizer in each neighborhood who recruited a group of residents to serve as a community action board. Key variables included perceptions of neighborhood mobilization by youth, parents, and key neighborhood leaders. DATA COLLECTION/EXTRACTION METHODS: Youth surveys were self-administered during school hours. Parent and neighborhood leader surveys were conducted over the phone by trained interviewers. PRINCIPAL FINDINGS: Survey results showed that mobilization increased to the same degree in both intervention and control neighborhoods with no evidence of an overall intervention effect. There did appear to be a relative increase in mobilization in the neighborhood with the highest level of intervention activity. CONCLUSION: This randomized study failed to demonstrate a measurable effect for a community mobilization intervention. It is uncertain whether the negative finding was because of a lack of strength of the interventions or problems detecting intervention effects using individual-level closed-end surveys.

Published
2001

104. Type inference in context

Author

Gundry, A., McBride, C., McKinna, J., Gundry, A., McBride, C., and McKinna, J.

Abstract

MSFP'10 : third ACM SIGPLAN workshop on Mathematically structured functional programming, Contains fulltext : 83744.pdf (publisher's version ) (Open Access)

Published
2010

105. Endothelium-dependent relaxation and hyperpolarization in guinea-pig coronary artery: role of epoxyeicosatrienoic acid

Author

Eckman, D M, Hopkins, N, McBride, C, and Keef, K D

Subjects
Male, Arachidonic Acid, Muscle Relaxation, Vasodilator Agents, Guinea Pigs, Arteries, In Vitro Techniques, Coronary Vessels, Acetylcholine, Membrane Potentials, Biological Factors, 8,11,14-Eicosatrienoic Acid, 1-Methyl-3-isobutylxanthine, Papers, cardiovascular system, Potassium Channel Blockers, Animals, Cytochrome P-450 Enzyme Inhibitors, lipids (amino acids, peptides, and proteins), Endothelium, Vascular, 4-Aminopyridine, Enzyme Inhibitors
Abstract

1. Acetylcholine (ACh) elicits an endothelium-dependent relaxation and hyperpolarization in the absence of nitric oxide (NO) and prostaglandin synthesis in the guinea-pig coronary artery (GPCA). This response has been attributed to a factor termed endothelial-derived hyperpolarizing factor (EDHF). Recently it has been suggested that EDHF may be a cytochrome P450 product of arachidonic acid (AA) i.e., an epoxyeicosatrienoic acid (EET). The present study investigated whether this pathway could account for the response to ACh observed in the GPCA in the presence of 100 microM N(omega)-nitro-L-arginine and 10 microM indomethacin. 2. ACh, AA and 11,12-EET each produced concentration-dependent relaxations in arteries contracted with the H1-receptor agonist AEP (2,2-aminoethylpyridine). The AA-induced relaxation was significantly enhanced in the presence of the cyclo-oxygenase/lipoxygenase inhibitor, eicosatetranynoic acid (30 microM). 3. The cytochrome P450 inhibitors proadifen (10 microM) and clotrimazole (10 microM) inhibited ACh, lemakalim (LEM) and AA-induced relaxation, whereas 17-octadecynoic acid (100 microM) and 7-ethoxyresorufin (10 microM) were without effect on all three vasodilators. Proadifen and clotrimazole also inhibited ACh (1 microM) and LEM (1 microM)-induced hyperpolarization. 4. The ability of various potassium channel blockers to inhibit relaxation responses elicited with ACh, AA and 11,12-EET was also determined. Iberiotoxin (IBTX; 100 nM) was without effect on responses to ACh but significantly reduced responses to both AA and 11,12-EET. In contrast, 4-aminopyridine (4-AP; 5 mM) significantly reduced response to ACh but not responses to AA and 11,12-EET. Combined IBTX plus (4-AP) inhibited the ACh-induced relaxation to a greater extent than 4-AP alone. Apamin (1 microM), glibenclamide (10 microM) and BaCl2 (50 microM) had no significant effect on responses to ACh, AA and 11,12-EET. 5. IBTX (100 nM) significantly reduced both 11,12-EET (33 microM) and AA (30 microM) hyperpolarization without affecting the ACh (1 microM)-induced hyperpolarization. In contrast, 4-AP significantly reduced the ACh-induced hyperpolarization without affecting either AA or 11,12-EET-induced hyperpolarizations. 6. In summary, our results suggest that the coronary endothelium releases a factor upon application of AA which hyperpolarizes the smooth muscle. The similarity of pharmacology between AA and 11,12-EET suggests that this factor is an EET. However, the disparity of pharmacology between responses to ACh versus responses to 11,12-EET do not support the hypothesis that EETs represent the predominant factor which ACh releases from the endothelium that leads to NO- and prostaglandin-independent hyperpolarization and relaxation in the GPCA.

Published
1998

106. An optimized correlation function estimator for galaxy surveys

Author

Vargas-Magaña, M., primary, Bautista, J. E., additional, Hamilton, J.-Ch., additional, Busca, N. G., additional, Aubourg, É., additional, Labatie, A., additional, Le Goff, J.-M., additional, Escoffier, S., additional, Manera, M., additional, McBride, C. K., additional, Schneider, D. P., additional, and Willmer, Ch. N. A., additional

Published
2013
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108. Genetic structure of mourning cuttlefish (Sepia plangon Gray, 1849) in Sydney Harbour, Australia.

Author

Umbers, K. D. L., McBride, C., Despres, F., Williamson, J. E., and Stow, A. J.

Subjects
*CUTTLEFISH, *MOLLUSK genetics, *DISPERSAL (Ecology), *AMPLIFIED fragment length polymorphism, *INBREEDING, *ANIMAL behavior
Abstract

Knowledge of behaviours, including sex-biased dispersal and kin-association, provides important insight into the costs and benefits of group-living. Such behaviours can be difficult to observe directly, but have quantifiable genetic signatures that allow us to determine their occurrence within and among groups. The mourning cuttlefish Sepia plangon Gray, 1849 is both solitary and found in groups at different locations inside Sydney Harbour. Here we describe the genetic relatedness of individuals from four sampling locations, up to 7 km apart, within Sydney Harbour. We also describe the relatedness of juveniles swimming together in small groups of up to seven individuals and the relatedness of 32 adults found in 16 mating pairs, to evaluate the risk of inbreeding. We estimate relatedness with data from 52 amplified fragment length polymorphism (AFLP) loci. We found no evidence that groups of juveniles consisted of related individuals and therefore suggest that kin do not preferentially associate. Additionally, we found that relatedness between adult pairs did not differ from random. Taken together, these results suggest that the risk of inbreeding in this species is low. No genetic structure was detected among groups of juvenile S. plangon across our sampling locations, implying regular dispersal and gene flow among locations separated by distances of up to 7 km. We therefore suggest that group formation in S. plangon does not incur the risk of inbreeding or tend indirectly to benefit related individuals sharing the same group. [ABSTRACT FROM AUTHOR]

Published
2016
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109. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: baryon acoustic oscillations in the Data Release 9 spectroscopic galaxy sample

Author

Anderson, L., primary, Aubourg, E., additional, Bailey, S., additional, Bizyaev, D., additional, Blanton, M., additional, Bolton, A. S., additional, Brinkmann, J., additional, Brownstein, J. R., additional, Burden, A., additional, Cuesta, A. J., additional, da Costa, L. A. N., additional, Dawson, K. S., additional, de Putter, R., additional, Eisenstein, D. J., additional, Gunn, J. E., additional, Guo, H., additional, Hamilton, J.-C., additional, Harding, P., additional, Ho, S., additional, Honscheid, K., additional, Kazin, E., additional, Kirkby, D., additional, Kneib, J.-P., additional, Labatie, A., additional, Loomis, C., additional, Lupton, R. H., additional, Malanushenko, E., additional, Malanushenko, V., additional, Mandelbaum, R., additional, Manera, M., additional, Maraston, C., additional, McBride, C. K., additional, Mehta, K. T., additional, Mena, O., additional, Montesano, F., additional, Muna, D., additional, Nichol, R. C., additional, Nuza, S. E., additional, Olmstead, M. D., additional, Oravetz, D., additional, Padmanabhan, N., additional, Palanque-Delabrouille, N., additional, Pan, K., additional, Parejko, J., additional, Paris, I., additional, Percival, W. J., additional, Petitjean, P., additional, Prada, F., additional, Reid, B., additional, Roe, N. A., additional, Ross, A. J., additional, Ross, N. P., additional, Samushia, L., additional, Sanchez, A. G., additional, Schlegel, D. J., additional, Schneider, D. P., additional, Scoccola, C. G., additional, Seo, H.-J., additional, Sheldon, E. S., additional, Simmons, A., additional, Skibba, R. A., additional, Strauss, M. A., additional, Swanson, M. E. C., additional, Thomas, D., additional, Tinker, J. L., additional, Tojeiro, R., additional, Magana, M. V., additional, Verde, L., additional, Wagner, C., additional, Wake, D. A., additional, Weaver, B. A., additional, Weinberg, D. H., additional, White, M., additional, Xu, X., additional, Yeche, C., additional, Zehavi, I., additional, and Zhao, G.-B., additional

Published
2012
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110. Freyd is Kleisli, for Arrows

Author

McBride, C., Uustalu, T., Jacobs, B.P.F., Hasuo, I., McBride, C., Uustalu, T., Jacobs, B.P.F., and Hasuo, I.

Abstract

Contains fulltext : 35849.pdf ( ) (Open Access)

Published
2006

112. The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: cosmological implications of the large-scale two-point correlation function

Author

Sánchez, Ariel G., primary, Scóccola, C. G., additional, Ross, A. J., additional, Percival, W., additional, Manera, M., additional, Montesano, F., additional, Mazzalay, X., additional, Cuesta, A. J., additional, Eisenstein, D. J., additional, Kazin, E., additional, McBride, C. K., additional, Mehta, K., additional, Montero-Dorta, A. D., additional, Padmanabhan, N., additional, Prada, F., additional, Rubiño-Martín, J. A., additional, Tojeiro, R., additional, Xu, X., additional, Magaña, M. Vargas, additional, Aubourg, E., additional, Bahcall, N. A., additional, Bailey, S., additional, Bizyaev, D., additional, Bolton, A. S., additional, Brewington, H., additional, Brinkmann, J., additional, Brownstein, J. R., additional, Gott, J. Richard, additional, Hamilton, J. C., additional, Ho, S., additional, Honscheid, K., additional, Labatie, A., additional, Malanushenko, E., additional, Malanushenko, V., additional, Maraston, C., additional, Muna, D., additional, Nichol, R. C., additional, Oravetz, D., additional, Pan, K., additional, Ross, N. P., additional, Roe, N. A., additional, Reid, B. A., additional, Schlegel, D. J., additional, Shelden, A., additional, Schneider, D. P., additional, Simmons, A., additional, Skibba, R., additional, Snedden, S., additional, Thomas, D., additional, Tinker, J., additional, Wake, D. A., additional, Weaver, B. A., additional, Weinberg, David H., additional, White, Martin, additional, Zehavi, I., additional, and Zhao, G., additional

Published
2012
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115. THE CLUSTERING OF MASSIVE GALAXIES ATz∼ 0.5 FROM THE FIRST SEMESTER OF BOSS DATA

Author

White, Martin, primary, Blanton, M., additional, Bolton, A., additional, Schlegel, D., additional, Tinker, J., additional, Berlind, A., additional, da Costa, L., additional, Kazin, E., additional, Lin, Y.-T., additional, Maia, M., additional, McBride, C. K., additional, Padmanabhan, N., additional, Parejko, J., additional, Percival, W., additional, Prada, F., additional, Ramos, B., additional, Sheldon, E., additional, de Simoni, F., additional, Skibba, R., additional, Thomas, D., additional, Wake, D., additional, Zehavi, I., additional, Zheng, Z., additional, Nichol, R., additional, Schneider, Donald P., additional, Strauss, Michael A., additional, Weaver, B. A., additional, and Weinberg, David H., additional

Published
2011
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116. Not all biologics are equal!

Author

Shah, B. C., primary, Tiwari, M. M., additional, Goede, M. R., additional, Eichler, M. J., additional, Hollins, R. R., additional, McBride, C. L., additional, Thompson, J. S., additional, and Oleynikov, D., additional

Published
2010
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121. Light-dependent hydrogen production by C. reinhardi

Author

Lien, S, Mcbride, C, Togasaki, R, and San Pietro, A

Subjects
Energy Production And Conversion
Abstract

The activity of hydrogenase in nonsynchronous, photoheterotrophically grown cells of C. reinhardi is a function of culture age. Rapidly growing cultures (exponential phase) exhibit lower hydrogenase activity than early stationary phase cultures. During prolonged dark anaerobic incubation the hydrogenase activity attains a maximal value in two to five hours. The activity declines rapidly after three to four hours of anaerobic incubation unless the pH of the suspending medium is maintained above 6.0. In C. reinhardi the source of electrons for hydrogen photoproduction appears to be derived mainly from water oxidation. However, when the water-splitting complex of photosystem II is impaired by a mutational block, the organism can utilize intracellular organic reductants as substrate for H2 production in a light-dependent reaction involving both PSII and PSI. When photosynthetic electron transport is uncoupled from phosphorylation, a rate of 174 micromoles of hydrogen evolved per mg cells per hour is observed. This rate of hydrogen photoproduction corresponds to 76% of the reductant generating capacity of PSII under steady-state photosynthesis.

Published
1979

126. Development of complex atherosclerotic lesions in pigs with inherited hyper-LDL cholesterolemia bearing mutant alleles for apolipoprotein B

Author

Prescott, M. F., McBride, C. H., Hasler-Rapacz, J., Von Linden, J., and Rapacz, J.

Subjects
Hyperlipoproteinemia Type II, Aging, Arteriosclerosis, Swine, Mutation, Microscopy, Electron, Scanning, Animals, lipids (amino acids, peptides, and proteins), Arteries, Cholesterol, LDL, Alleles, Research Article, Apolipoproteins B
Abstract

The development of atherosclerotic lesions was studied in pigs aged 4 to 54 months with inherited hyperlow-density lipoprotein (LDL) and hypercholesterolemia (IHLC pigs). These pigs bear the Lpb5 and Lpu1 mutant alleles for apolipoproteins B and U and demonstrate spontaneously elevated cholesterol levels, due primarily to elevated LDL. By 1 year of age, IHLC pigs exhibited focal lesions in the major coronary, iliac, and femoral arteries that were composed of macrophage-derived from cells and smooth muscle cells. Peripheral arterial lesions were more fibrous than those found in the coronaries. By 2 years of age, complicated stenotic lesions containing fibrous caps, necrotic cores, cholesterol clefts, granular calcium deposits, and neovascularization deep within the lesion were common in the major coronary vessels. Peripheral vascular lesions were more smooth muscle cell-rich and fibrotic. By 3 years of age, neovascularization was observed throughout the intimal lesion, and hemorrhage and rupture were common. The extent of complicated lesion formation correlated with both the degree and duration of hypercholesterolemia, with the most stenotic lesions observed in the coronary arteries of the oldest animals having the highest cholesterol levels. Thus IHLC pigs with mutant apolipoproteins B and U develop complicated atherosclerotic plaques that closely resemble advanced atherosclerotic lesions found in humans.

Published
1991

127. Comment on "Using groundwater age and hydrochemistry to understand sources and dynamics of nutrient contamination through the catchment into Lake Rotorua, New Zealand" by Morgenstern et al. (2015).

Author

Abell, J. M., Hamilton, D. P., and McBride, C. G.

Abstract

This Comment addresses a key conclusion in the paper entitled "Using groundwater age and hydrochemistry to understand sources and dynamics of nutrient contamination through the catchment into Lake Rotorua, New Zealand" by Morgenstern et al. (2015). The authors analyse hydrochemistry data and conclude that "the only effective way to limit algae blooms and improve lake water quality in such environments is by limiting the nitrate load". We undertook the crucial task of examining this conclusion because it contradicts the current strategy of limiting both phosphorus and nitrogen loads to the lake, supported by a multi-million dollar programme of action. Following careful con sideration, we believe that the conclusion is invalid and outline four reasons to support our assessment. Our comments do not relate to the methodology or results that are presented by Morgenstern et al. (2015), and we recognise that their paper makes an otherwise highly valuable contribution to understanding hydro-chemical processes in the catchment. [ABSTRACT FROM AUTHOR]

Published
2015
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135. Highly Parallel SNP Genotyping

Author

FAN, J.-B., primary, OLIPHANT, A., additional, SHEN, R., additional, KERMANI, B.G., additional, GARCIA, F., additional, GUNDERSON, K.L., additional, HANSEN, M., additional, STEEMERS, F., additional, BUTLER, S.L., additional, DELOUKAS, P., additional, GALVER, L., additional, HUNT, S., additional, MCBRIDE, C., additional, BIBIKOVA, M., additional, RUBANO, T., additional, CHEN, J., additional, WICKHAM, E., additional, DOUCET, D., additional, CHANG, W., additional, CAMPBELL, D., additional, ZHANG, B., additional, KRUGLYAK, S., additional, BENTLEY, D., additional, HAAS, J., additional, RIGAULT, P., additional, ZHOU, L., additional, STUELPNAGEL, J., additional, and CHEE, M.S., additional

Published
2003
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136. Simulating Diffuse Light in Galaxy Clusters.

Author

Leibundgut, Bruno, Saviane, Ivo, Ivanov, Valentin D., Borissova, Jordanka, Rudick, C.S., Mihos, J.C., and McBride, C.

Abstract

Using N-body simulations, we have modeled the production and evolution of low surface brightness, diffuse intra-cluster light (ICL) in galaxy clusters. By creating simulated observations of the clusters we have measured the evolution of the ICL luminosity throughout the dynamical history of the clusters. We find that ICL production tends to occur in short, discrete events, which correlate very strongly with strong, small-scale interactions and accretions between groups within the clusters. [ABSTRACT FROM AUTHOR]

Published
2007
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142. Patients’ Experiences of Using Smartphone Apps to Support Self-Management and Improve Medication Adherence in Hypertension: Qualitative Study

Author

McBride, Ciara M, Morrissey, Eimear C, and Molloy, Gerard J

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundWorldwide, hypertension control rates remain suboptimal despite clinically effective antihypertensive drug therapy. Patient failure to take medication as prescribed (ie, nonadherence) is the most important factor contributing to poor control. Smartphone apps can facilitate the delivery of evidence-based behavior change techniques to improve adherence and may provide a scalable, usable, and feasible method to deliver self-management support. ObjectiveThe aim of this study is to explore patients’ experiences of the usability and feasibility of smartphone apps to support self-management and improve medication adherence in hypertension. MethodsA qualitative descriptive study was conducted. A total of 11 people living with hypertension from the West of Ireland were sampled purposively and interviewed about their experience of using a self-management app for a 4-week period, which included two key functionalities: self-monitoring of blood pressure (BP) and medication reminders. Thematic analysis was carried out on the semistructured interview data. ResultsParticipants’ age ranged from 43 to 74 years (mean 62 years, SD 9.13). Three themes were identified: digital empowerment of self-management, human versus digital systems, and digital sustainability. Although patients’ experience of using the technology to self-monitor BP was one of empowerment, characterized by an enhanced insight and understanding into their condition, control, and personal responsibility, the reminder function was only feasible for patients who reported unintentional nonadherence to treatment. Patients experienced the app as a sustainable tool to support self-management and found it easy to use, including those with limited technological competence. ConclusionsThe study’s findings provide new insights into the experience of using apps to support medication adherence in hypertension. Overall, the data support apps as a usable and feasible method to aid self-management of hypertension and highlight the need for personalized functionality, particularly with regard to medication adherence reminder strategies. The study’s findings challenge the perspective that the use of these technologies to support self-management can inevitably add to the burden of treatment experienced by patients.

Published
2020
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143. Web-Based Health Coaching for Spinal Cord Injury: Results From a Mixed Methods Feasibility Evaluation

Author

Allin, Sonya, Shepherd, John, Thorson, Teri, Tomasone, Jennifer, Munce, Sarah, Linassi, Gary, McBride, Christopher B, Jiancaro, Tizneem, and Jaglal, Susan

Subjects
Medical technology, R855-855.5
Abstract

BackgroundIndividuals with spinal cord injury (SCI) are at high risk of experiencing secondary conditions like pressure injuries. Self-management programs may reduce the risk of complications, but traditional programs have proven to be insufficiently tailored to the needs of people with SCI. To overcome barriers to self-management support, a web-based, self-management program was developed for Canadians with SCI called SCI & U. ObjectiveThis study aims to evaluate the feasibility and potential impact of the SCI & U program in the context of a mixed methods pilot study. MethodsThe study followed an explanatory, sequential mixed methods design. Participants (N=11) were Canadians with SCI who had been living in the community for more than 1 year. Each took part in a self-paced, six-session self-management program guided by a trained peer health coach. During sessions, participants could discuss a health topic with their coach from a predefined list (eg, skin or bowel management). Quantitative data were gathered before and after program participation to assess program feasibility and impact. Feasibility measures included attrition rates, frequency of topics selected, and recorded goals, whereas impact measures included measures of self-efficacy (University of Washington Self-Efficacy Scale [UW-SES]), mood (Personal Health Questionnaire Depression Scale [PHQ-8]), secondary conditions (Spinal Cord Injury Secondary Conditions Scale [SCI-SCS]), and resilience (Spinal Cord Injury Quality of Life Resilience Scale [SCI-QOL-R]). Qualitative measures were based on postintervention interviews; these were designed to confirm and expand on quantitative ResultsOf the 11 participants, 10 completed pre- and postassessments, and 6 coaching sessions. Sessions lasted between 31 and 81 min (average 55, SD 13), and the duration of the program ranged from 35 to 88 days (average 56, SD 23). Diet and exercise were selected as topics 40% (20/50 sessions with topics) of the time, whereas topics such as mental health, bladder management, pain, and bowel management were chosen less frequently. Results gathered before and after the pilot study demonstrated improvements with moderate effect sizes on the UW-SES and the electronic health literacy scale (ie, Hedges g>0.5). Effect sizes for measures of resilience (SCI-QOL-R), depression (PHQ-8), and secondary conditions (SCI-SCS) were small (ie, Hedges g>0.3). Qualitative results confirmed a common focus on diet and exercise, and defined coaches as sources of accountability, information, reassurance and affirmation, and emotional and technical support. ConclusionsResults demonstrated that a web-based self-management program is feasible and acceptable by Canadians with SCI. Results also indicated a web-based, peer-led self-management program may impact resilience, self-efficacy, mood, and secondary complications. Finally, results illuminated the role of the coach in facilitating behavior change. Future work seeks to validate results in the context of a randomized controlled trial.

Published
2020
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