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101. Physical exercise volume, type, and intensity and risk of all-cause mortality and cardiovascular events in patients with cardiovascular disease : a mediation analysis

Author

Bonekamp, Nadia E., May, Anne M., Halle, Martin, Dorresteijn, Jannick A.N., van der Meer, Manon G., Ruigrok, Ynte M., de Borst, Gert J., Geleijnse, Johanna M., Visseren, Frank L.J., Koopal, Charlotte, Bonekamp, Nadia E., May, Anne M., Halle, Martin, Dorresteijn, Jannick A.N., van der Meer, Manon G., Ruigrok, Ynte M., de Borst, Gert J., Geleijnse, Johanna M., Visseren, Frank L.J., and Koopal, Charlotte

Abstract

Aims To estimate the relation between physical exercise volume, type, and intensity with all-cause mortality and recurrent vascular events in patients with cardiovascular disease (CVD) and to quantify to what extent traditional cardiovascular risk factors mediate these relations. Methods In the prospective UCC-SMART cohort (N = 8660), the associations of clinical endpoints and physical exercise volume and results (metabolic equivalent of task hours per week, METh/wk), type (endurance vs. endurance + resistance), and intensity (moderate vs. vigorous) were estimated using multivariable-adjusted Cox models. The proportion mediated effect (PME) through body mass index, systolic blood pressure, low-density lipoprotein cholesterol, insulin sensitivity, and systemic inflammation was assessed using structural equation models. Sixty-one percent of patients (73% male, age 61 ± 10 years, >70% receiving lipid-lowering and blood pressure–lowering medications) reported that they did not exercise. Over a median follow-up of 9.5 years [interquartile range (IQR) 5.1–14.0], 2256 deaths and 1828 recurrent vascular events occurred. The association between exercise volume had a reverse J-shape with a nadir at 29 (95% CI 24–29) METh/wk, corresponding with a HR 0.56 (95% CI 0.48–0.64) for all-cause mortality and HR 0.63 (95% CI 0.55–0.73) for recurrent vascular events compared with no exercise. Up to 38% (95% CI 24–61) of the association was mediated through the assessed risk factors of which insulin sensitivity (PME up to 12%, 95% CI 5–25) and systemic inflammation (PME up to 18%, 95% CI 9–37) were the most important. Conclusion Regular physical exercise is significantly related with reduced risks of all-cause mortality and recurrent vascular events in patients with CVD. In this population with high rates of lipid-lowering and blood pressure–lowering medication use, exercise benefits were mainly mediated through systemic inflammation and insulin resistance.

Published
2023

102. Moderators of exercise effects on self-reported cognitive functioning in cancer survivors: an individual participant data meta-analysis

Author

Hiensch, Anouk E., Beckhaus, Julia, Witlox, Lenja, Monninkhof, Evelyn M., Schagen, Sanne B., van Vulpen, Jonna K., Sweegers, Maike G., Newton, Robert U., Aaronson, Neil K., Galvão, Daniel A., Steindorf, Karen, Stuiver, Martijn M., Mesters, Ilse, Knoop, Hans, Goedendorp, Martine M., Bohus, Martin, Thorsen, Lene, Schulz, Karl Heinz, Schmidt, Martina E., Ulrich, Cornelia M., Sonke, Gabe S., van Harten, Wim H., Winters-Stone, Kerri M., Velthuis, Miranda J., Taaffe, Dennis R., van Mechelen, Willem, Kersten, Marie J., Nollet, Frans, Wiskemann, Joachim, Buffart, Laurien M., May, Anne M., Hiensch, Anouk E., Beckhaus, Julia, Witlox, Lenja, Monninkhof, Evelyn M., Schagen, Sanne B., van Vulpen, Jonna K., Sweegers, Maike G., Newton, Robert U., Aaronson, Neil K., Galvão, Daniel A., Steindorf, Karen, Stuiver, Martijn M., Mesters, Ilse, Knoop, Hans, Goedendorp, Martine M., Bohus, Martin, Thorsen, Lene, Schulz, Karl Heinz, Schmidt, Martina E., Ulrich, Cornelia M., Sonke, Gabe S., van Harten, Wim H., Winters-Stone, Kerri M., Velthuis, Miranda J., Taaffe, Dennis R., van Mechelen, Willem, Kersten, Marie J., Nollet, Frans, Wiskemann, Joachim, Buffart, Laurien M., and May, Anne M.

Abstract

Purpose: This individual participant data meta-analysis (IPD-MA) assesses exercise effects on self-reported cognitive functioning (CF) and investigates whether effects differ by patient-, intervention-, and exercise-related characteristics. Methods: IPD from 16 exercise RCTs, including 1987 patients across multiple types of non-metastatic cancer, was pooled. A one-stage IPD-MA using linear mixed-effect models was performed to assess exercise effects on self-reported CF (z-score) and to identify whether the effect was moderated by sociodemographic, clinical, intervention- and exercise-related characteristics, or fatigue, depression, anxiety, and self-reported CF levels at start of the intervention (i.e., baseline). Models were adjusted for baseline CF and included a random intercept at study level to account for clustering of patients within studies. A sensitivity analysis was performed in patients who reported cognitive problems at baseline. Results: Minimal significant beneficial exercise effects on self-reported CF (=−0.09 [−0.16; −0.02]) were observed, with slightly larger effects when the intervention was delivered post-treatment (n=745, =−0.13 [−0.24; −0.02]), and no significant effect during cancer treatment (n=1,162, =−0.08 [−0.18; 0.02]). Larger effects were observed in interventions of 12 weeks or shorter (=−0.14 [−0.25; −0.04]) or 24 weeks or longer (=−0.18 [−0.32; −0.02]), whereas no effects were observed in interventions of 12–24 weeks (=0.01 [−0.13; 0.15]). Exercise interventions were most beneficial when provided to patients without anxiety symptoms (=−0.10 [−0.19; −0.02]) or after completion of treatment in patients with cognitive problems (=−0.19 [−0.31; −0.06]). No other significant moderators were identified. Conclusions: This cross-cancer IPD meta-analysis observed small beneficial exercise effects on self-reported CF when the intervention was delivered post-treatment, especially in patients who reported cognitive problems at baseline. Implication

Published
2023

103. Pain and Opioid Consumption After Laparoscopic Versus Open Gastrectomy for Gastric Cancer:A Secondary Analysis of a Multicenter Randomized Clinical Trial (LOGICA-Trial)

Author

van der Veen, Arjen, Ramaekers, Mark, Marsman, Marije, Brenkman, Hylke J.F., Seesing, Maarten F.J., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., Stoot, Jan H.M.B., Tegels, Juul J.W., Wijnhoven, Bas P.L., de Steur, Wobbe O., Kouwenhoven, Ewout A., Wassenaar, Eelco B., Draaisma, Werner A., Gisbertz, Suzanne S., van der Peet, Donald L., May, Anne M., Ruurda, Jelle P., van Hillegersberg, Richard, Haverkamp, Leonie, Ponten, Jeroen E.H., Heesakkers, Fanny F.B.M., Hulsewe, Karel W.E., Tweed, Thais T.T., Lagarde, Sjoerd M., van Lanschot, Jan J.B., Hartgrink, Henk H., van Det, Marc J., van Duijvendijk, Peter, van der Zaag, Edwin S., Broeders, Ivo A.M.J., van Berge Henegouwen, Mark I., Daams, Freek, van der Veen, Arjen, Ramaekers, Mark, Marsman, Marije, Brenkman, Hylke J.F., Seesing, Maarten F.J., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., Stoot, Jan H.M.B., Tegels, Juul J.W., Wijnhoven, Bas P.L., de Steur, Wobbe O., Kouwenhoven, Ewout A., Wassenaar, Eelco B., Draaisma, Werner A., Gisbertz, Suzanne S., van der Peet, Donald L., May, Anne M., Ruurda, Jelle P., van Hillegersberg, Richard, Haverkamp, Leonie, Ponten, Jeroen E.H., Heesakkers, Fanny F.B.M., Hulsewe, Karel W.E., Tweed, Thais T.T., Lagarde, Sjoerd M., van Lanschot, Jan J.B., Hartgrink, Henk H., van Det, Marc J., van Duijvendijk, Peter, van der Zaag, Edwin S., Broeders, Ivo A.M.J., van Berge Henegouwen, Mark I., and Daams, Freek

Abstract

Background:Laparoscopic gastrectomy could reduce pain and opioid consumption, compared to open gastrectomy. However, it is difficult to judge the clinical relevance of this reduction, since these outcomes are reported in few randomized trials and in limited detail. Methods: This secondary analysis of a multicenter randomized trial compared laparoscopic versus open gastrectomy for resectable gastric adenocarcinoma (cT1-4aN0-3bM0). Postoperative pain was analyzed by opioid consumption in oral morphine equivalents (OME, mg/day) at postoperative day (POD) 1–5, WHO analgesic steps, and Numeric Rating Scales (NRS, 0–10) at POD 1–10 and discharge. Regression and mixed model analyses were performed, with and without correction for epidural analgesia. Results: Between 2015 and 2018, 115 patients in the laparoscopic group and 110 in the open group underwent surgery. Some 16 patients (14%) in the laparoscopic group and 73 patients (66%) in the open group received epidural analgesia. At POD 1–3, mean opioid consumption was 131, 118, and 53 mg OME lower in the laparoscopic group, compared to the open group, respectively (all p < 0.001). After correcting for epidural analgesia, these differences remained significant at POD 1–2 (47 mg OME, p = 0.002 and 69 mg OME, p < 0.001, respectively). At discharge, 27% of patients in the laparoscopic group and 43% patients in the open group used oral opioids (p = 0.006). Mean highest daily pain scores were between 2 and 4 at all PODs, < 2 at discharge, and did not relevantly differ between treatment arms. Conclusion: In this multicenter randomized trial, postoperative pain was comparable between laparoscopic and open gastrectomy. After laparoscopic gastrectomy, this was generally achieved without epidural analgesia and with fewer opioids. Trial Registration: NCT02248519.

Published
2023

104. Effects of exercise after oesophagectomy on body composition and adequacy of energy and protein intake:PERFECT multicentre randomized controlled trial

Author

Hiensch, Anouk, Steenhagen, Elles, van Vulpen, Jonna K., Ruurda, Jelle P., Nieuwenhuijzen, Grard A.P., Kouwenhoven, Ewout A., Groenendijk, Richard P.R., van der Peet, Donald L., Rosman, Camiel, Wijnhoven, Bas P.L., van Berge Henegouwen, Mark I., van Laarhoven, Hanneke W.M., van Hillegersberg, Richard, Siersema, Peter D., May, Anne M., Hiensch, Anouk, Steenhagen, Elles, van Vulpen, Jonna K., Ruurda, Jelle P., Nieuwenhuijzen, Grard A.P., Kouwenhoven, Ewout A., Groenendijk, Richard P.R., van der Peet, Donald L., Rosman, Camiel, Wijnhoven, Bas P.L., van Berge Henegouwen, Mark I., van Laarhoven, Hanneke W.M., van Hillegersberg, Richard, Siersema, Peter D., and May, Anne M.

Published
2023

105. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases:Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Bond, Marinde J.G., Kuiper, Babette I., Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas, Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Kazemier, Geert, May, Anne M., Punt, Cornelis J.A., Swijnenburg, Rutger Jan, Bond, Marinde J.G., Kuiper, Babette I., Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J., Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas, Hermans, John J., de Jong, Koert P., Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., Kazemier, Geert, May, Anne M., Punt, Cornelis J.A., and Swijnenburg, Rutger Jan

Abstract

Background: Consensus on resectability criteria for colorectal cancer liver metastases (CRLM) is lacking, resulting in differences in therapeutic strategies. This study evaluated variability of resectability assessments and local treatment plans for patients with initially unresectable CRLM by the liver expert panel from the randomised phase III CAIRO5 study. Methods: The liver panel, comprising surgeons and radiologists, evaluated resectability by predefined criteria at baseline and 2-monthly thereafter. If surgeons judged CRLM as resectable, detailed local treatment plans were provided. The panel chair determined the conclusion of resectability status and local treatment advice, and forwarded it to local surgeons. Results: A total of 1149 panel evaluations of 496 patients were included. Intersurgeon disagreement was observed in 50% of evaluations and was lower at baseline than follow-up (36% vs. 60%, p < 0.001). Among surgeons in general, votes for resectable CRLM at baseline and follow-up ranged between 0–12% and 27–62%, and for permanently unresectable CRLM between 3–40% and 6–47%, respectively. Surgeons proposed different local treatment plans in 77% of patients. The most pronounced intersurgeon differences concerned the advice to proceed with hemihepatectomy versus parenchymal-preserving approaches. Eighty-four percent of patients judged by the panel as having resectable CRLM indeed received local treatment. Local surgeons followed the technical plan proposed by the panel in 40% of patients. Conclusion: Considerable variability exists among expert liver surgeons in assessing resectability and local treatment planning of initially unresectable CRLM. This stresses the value of panel-based decisions, and the need for consensus guidelines on resectability criteria and technical approach to prevent unwarranted variability in clinical practice.

Published
2023

106. The role of tumour biological factors in technical anatomical resectability assessment of colorectal liver metastases following induction systemic treatment:An analysis of the Dutch CAIRO5 trial

Author

Bolhuis, Karen, Bond, Marinde J.G., Van Amerongen, Martin J., Komurcu, Aysun, Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas M., Hermans, John J., De Jong, Koert P., Kazemier, Geert, Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., May, Anne M., Punt, Cornelis J.A., Swijnenburg, Rutger Jan, Bolhuis, Karen, Bond, Marinde J.G., Van Amerongen, Martin J., Komurcu, Aysun, Chapelle, Thiery, Dejong, Cornelis H.C., Engelbrecht, Marc R.W., Gerhards, Michael F., Grünhagen, Dirk J., van Gulik, Thomas M., Hermans, John J., De Jong, Koert P., Kazemier, Geert, Klaase, Joost M., Kok, Niels F.M., Leclercq, Wouter K.G., Liem, Mike S.L., van Lienden, Krijn P., Molenaar, I. Quintus, Neumann, Ulf P., Patijn, Gijs A., Rijken, Arjen M., Ruers, Theo M., Verhoef, Cornelis, de Wilt, Johannes H.W., May, Anne M., Punt, Cornelis J.A., and Swijnenburg, Rutger Jan

Abstract

Background: Large inter-surgeon variability exists in technical anatomical resectability assessment of colorectal cancer liver-only metastases (CRLM) following induction systemic therapy. We evaluated the role of tumour biological factors in predicting resectability and (early) recurrence after surgery for initially unresectable CRLM. Methods: 482 patients with initially unresectable CRLM from the phase 3 CAIRO5 trial were selected, with two-monthly resectability assessments by a liver expert panel. If no consensus existed among panel surgeons (i.e. same vote for (un)resectability of CRLM), conclusion was based on majority. The association of tumour biological (sidedness, synchronous CRLM, carcinoembryonic antigen and RAS/BRAFV600E mutation status) and technical anatomical factors with consensus among panel surgeons, secondary resectability and early recurrence (<6 months) without curative-intent repeat local treatment was analysed by uni- and pre-specified multivariable logistic regression. Results: After systemic treatment, 240 (50%) patients received complete local treatment of CRLM of which 75 (31%) patients experienced early recurrence without repeat local treatment. Higher number of CRLM (odds ratio 1.09 [95% confidence interval 1.03–1.15]) and age (odds ratio 1.03 [95% confidence interval 1.00–1.07]) were independently associated with early recurrence without repeat local treatment. In 138 (52%) patients, no consensus among panel surgeons was present prior to local treatment. Postoperative outcomes in patients with and without consensus were comparable. Conclusions: Almost a third of patients selected by an expert panel for secondary CRLM surgery following induction systemic treatment experience an early recurrence only amenable to palliative treatment. Number of CRLM and age, but no tumour biological factors are predictive, suggesting that until there are better biomarkers; resectability assessment remains primarily a technical anatomical de

Published
2023

107. Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Fontvieille, Emma, Viallon, Vivian, Recalde, Martina, Cordova, Reynalda, Jansana, Anna, Peruchet-Noray, Laia, Lennon, Hannah, Heath, Alicia K, Aune, Dagfinn, Christakoudi, Sofia, Katzke, Verena, Kaaks, Rudolf, Inan-Eroglu, Elif, Schulze, Matthias B, Mellemkjær, Lene, Tjønneland, Anne, Overvad, Kim, Farràs, Marta, Petrova, Dafina, Amiano, Pilar, Chirlaque, María-Dolores, Moreno-Iribas, Conchi, Tin Tin, Sandar, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Panico, Salvatore, May, Anne M, Monninkhof, Evelyn M, Weiderpass, Elisabete, Gunter, Marc J, Ferrari, Pietro, Freisling, Heinz, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Fontvieille, Emma, Viallon, Vivian, Recalde, Martina, Cordova, Reynalda, Jansana, Anna, Peruchet-Noray, Laia, Lennon, Hannah, Heath, Alicia K, Aune, Dagfinn, Christakoudi, Sofia, Katzke, Verena, Kaaks, Rudolf, Inan-Eroglu, Elif, Schulze, Matthias B, Mellemkjær, Lene, Tjønneland, Anne, Overvad, Kim, Farràs, Marta, Petrova, Dafina, Amiano, Pilar, Chirlaque, María-Dolores, Moreno-Iribas, Conchi, Tin Tin, Sandar, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Panico, Salvatore, May, Anne M, Monninkhof, Evelyn M, Weiderpass, Elisabete, Gunter, Marc J, Ferrari, Pietro, and Freisling, Heinz

Published
2023

108. Perspectives of patients with metastatic breast cancer on physical exercise programs: results from a survey in five European countries

Author

Epi Kanker Team B, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Sweegers, Maike G., Depenbusch, Johanna, Kampshoff, Caroline S., Aaronson, Neil K., Hiensch, Anouk, Wengström, Yvonne, Backman, Malin, Gunasekara, Nadira, Clauss, Dorothea, Pelaez, Mireia, Lachowicz, Milena, May, Anne M., Steindorf, Karen, Stuiver, Martijn M., Epi Kanker Team B, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Sweegers, Maike G., Depenbusch, Johanna, Kampshoff, Caroline S., Aaronson, Neil K., Hiensch, Anouk, Wengström, Yvonne, Backman, Malin, Gunasekara, Nadira, Clauss, Dorothea, Pelaez, Mireia, Lachowicz, Milena, May, Anne M., Steindorf, Karen, and Stuiver, Martijn M.

Published
2023

109. Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Castañeda, Jazmin, Gil-Lespinard, Mercedes, Almanza-Aguilera, Enrique, Llaha, Fjorida, Gómez, Jesús Humberto, Bondonno, Nicola, Tjønneland, Anne, Overvad, Kim, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Santucci de Magistris, Maria, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Brustad, Magritt, Lasheras, Cristina, Molina-Montes, Esther, Chirlaque, María Dolores, Barricarte, Aurelio, Sonestedt, Emily, da Silva, Marisa, Johansson, Ingegerd, Hultdin, Johan, May, Anne M., Forouhi, Nita G., Heath, Alicia K., Freisling, Heinz, Weiderpass, Elisabete, Scalbert, Augustin, Zamora-Ros, Raul, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Castañeda, Jazmin, Gil-Lespinard, Mercedes, Almanza-Aguilera, Enrique, Llaha, Fjorida, Gómez, Jesús Humberto, Bondonno, Nicola, Tjønneland, Anne, Overvad, Kim, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Santucci de Magistris, Maria, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Brustad, Magritt, Lasheras, Cristina, Molina-Montes, Esther, Chirlaque, María Dolores, Barricarte, Aurelio, Sonestedt, Emily, da Silva, Marisa, Johansson, Ingegerd, Hultdin, Johan, May, Anne M., Forouhi, Nita G., Heath, Alicia K., Freisling, Heinz, Weiderpass, Elisabete, Scalbert, Augustin, and Zamora-Ros, Raul

Published
2023

110. Translating Evidence from Dutch Exercise Oncology Trials in Patients with Breast Cancer into Clinical Practice Using the RE-AIM Framework

Author

Trialbureau Beeld, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Ten Tusscher, Marieke R., Stuiver, Martijn M., Kampshoff, Caroline S., Huijsmans, Rosalie J., Aaronson, Neil K., Velthuis, Miranda, Gal, Roxanne, Van Waart, Hanna, May, Anne M., Buffart, Laurien M., Trialbureau Beeld, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Ten Tusscher, Marieke R., Stuiver, Martijn M., Kampshoff, Caroline S., Huijsmans, Rosalie J., Aaronson, Neil K., Velthuis, Miranda, Gal, Roxanne, Van Waart, Hanna, May, Anne M., and Buffart, Laurien M.

Published
2023

111. Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity

Author

Epi Kanker Team B, Speerpunt Cancer, Cancer, MS Radiologie, Circulatory Health, Team Medisch, Epi Kanker, JC onderzoeksprogramma Kanker, Naaktgeboren, Willeke R, Stuiver, Martijn M, van Harten, Wim H, Aaronson, Neil K, Scott, Jessica M, Sonke, Gabe, van der Wall, Elsken, Velthuis, Miranda, Leiner, Tim, Teske, Arco J, May, Anne M, Groen, Wim G, Epi Kanker Team B, Speerpunt Cancer, Cancer, MS Radiologie, Circulatory Health, Team Medisch, Epi Kanker, JC onderzoeksprogramma Kanker, Naaktgeboren, Willeke R, Stuiver, Martijn M, van Harten, Wim H, Aaronson, Neil K, Scott, Jessica M, Sonke, Gabe, van der Wall, Elsken, Velthuis, Miranda, Leiner, Tim, Teske, Arco J, May, Anne M, and Groen, Wim G

Published
2023

112. Physical exercise in patients with testicular cancer treated with bleomycin, etoposide and cisplatin chemotherapy: pulmonary and vascular endothelial function-an exploratory analysis

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, van der Schoot, Gabriela G F, Ormel, Harm L, Westerink, Nico-Derk L, Wempe, Johan B, Lefrandt, Joop D, May, Anne M, Vrieling, Aline H, Meijer, Coby, Gietema, Jourik A, Walenkamp, Annemiek M E, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, van der Schoot, Gabriela G F, Ormel, Harm L, Westerink, Nico-Derk L, Wempe, Johan B, Lefrandt, Joop D, May, Anne M, Vrieling, Aline H, Meijer, Coby, Gietema, Jourik A, and Walenkamp, Annemiek M E

Published
2023

113. Effects of exercise after oesophagectomy on body composition and adequacy of energy and protein intake: PERFECT multicentre randomized controlled trial

Author

Epi Kanker Team B, Cancer, Afdeling Dietetiek, Arts-assistenten Radiotherapie, MCS-team, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Hiensch, Anouk, Steenhagen, Elles, van Vulpen, Jonna K., Ruurda, Jelle P., Nieuwenhuijzen, Grard A.P., Kouwenhoven, Ewout A., Groenendijk, Richard P.R., van der Peet, Donald L., Rosman, Camiel, Wijnhoven, Bas P.L., van Berge Henegouwen, Mark I., van Laarhoven, Hanneke W.M., van Hillegersberg, Richard, Siersema, Peter D., May, Anne M., Epi Kanker Team B, Cancer, Afdeling Dietetiek, Arts-assistenten Radiotherapie, MCS-team, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Hiensch, Anouk, Steenhagen, Elles, van Vulpen, Jonna K., Ruurda, Jelle P., Nieuwenhuijzen, Grard A.P., Kouwenhoven, Ewout A., Groenendijk, Richard P.R., van der Peet, Donald L., Rosman, Camiel, Wijnhoven, Bas P.L., van Berge Henegouwen, Mark I., van Laarhoven, Hanneke W.M., van Hillegersberg, Richard, Siersema, Peter D., and May, Anne M.

Published
2023

114. Physical exercise volume, type, and intensity and risk of all-cause mortality and cardiovascular events in patients with cardiovascular disease: a mediation analysis

Author

Interne Geneeskunde Vasculaire, Circulatory Health, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, MS Interne Geneeskunde, Team Medisch, Neurologen, Brain, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Unit Opleiding Aios, Bonekamp, Nadia E, May, Anne M, Halle, Martin, Dorresteijn, Jannick A N, van der Meer, Manon G, Ruigrok, Ynte M, de Borst, Gert J, Geleijnse, Johanna M, Visseren, Frank L J, Koopal, Charlotte, Interne Geneeskunde Vasculaire, Circulatory Health, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, MS Interne Geneeskunde, Team Medisch, Neurologen, Brain, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Unit Opleiding Aios, Bonekamp, Nadia E, May, Anne M, Halle, Martin, Dorresteijn, Jannick A N, van der Meer, Manon G, Ruigrok, Ynte M, de Borst, Gert J, Geleijnse, Johanna M, Visseren, Frank L J, and Koopal, Charlotte

Published
2023

115. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, Riboli, Elio, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio

Published
2023

116. Immunosuppression for immune-related adverse events during checkpoint inhibition: an intricate balance

Author

MS Medische Oncologie, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, CTI Van Wijk, Child Health, Infection & Immunity, Verheijden, Rik J, van Eijs, Mick J M, May, Anne M, van Wijk, Femke, Suijkerbuijk, Karijn P M, MS Medische Oncologie, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, CTI Van Wijk, Child Health, Infection & Immunity, Verheijden, Rik J, van Eijs, Mick J M, May, Anne M, van Wijk, Femke, and Suijkerbuijk, Karijn P M

Published
2023

117. ASO Visual Abstract: Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases-Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Quintus Molenaar, I, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, Swijnenburg, Rutger-Jan, Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Quintus Molenaar, I, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, and Swijnenburg, Rutger-Jan

Published
2023

118. The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K, Gunter, Marc J, Kaaks, Rudolf, Schulze, Matthias B, Fortner, Renée T, Antoniussen, Christian S, Dahm, Christina C, Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M, Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M, Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, Agudo, Antonio, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K, Gunter, Marc J, Kaaks, Rudolf, Schulze, Matthias B, Fortner, Renée T, Antoniussen, Christian S, Dahm, Christina C, Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M, Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M, Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, and Agudo, Antonio

Published
2023

119. Early Detection of Brain Metastases in a Supervised Exercise Program for Patients with Advanced Breast Cancer: A Case Report

Author

Epi Kanker, JC onderzoeksprogramma Kanker, Cancer, Pelaez, Mireia, Stuiver, Martijn M, Broekman, Marike, Schmitz, Kathryn H, Zopf, Eva M, Clauss, Dorothea, Wengström, Yvonne, Rosenberger, Friederike, Steindorf, Karen, Urruticoechea, Ander, May, Anne M, Epi Kanker, JC onderzoeksprogramma Kanker, Cancer, Pelaez, Mireia, Stuiver, Martijn M, Broekman, Marike, Schmitz, Kathryn H, Zopf, Eva M, Clauss, Dorothea, Wengström, Yvonne, Rosenberger, Friederike, Steindorf, Karen, Urruticoechea, Ander, and May, Anne M

Published
2023

121. Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases: Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group

Author

Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Molenaar, I Quintus, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, Swijnenburg, Rutger-Jan, Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, JC onderzoeksprogramma Kanker, Bond, Marinde J G, Kuiper, Babette I, Bolhuis, Karen, Komurcu, Aysun, van Amerongen, Martinus J, Chapelle, Thiery, Dejong, Cornelis H C, Engelbrecht, Marc R W, Gerhards, Michael F, Grünhagen, Dirk J, van Gulik, Thomas, Hermans, John J, de Jong, Koert P, Klaase, Joost M, Kok, Niels F M, Leclercq, Wouter K G, Liem, Mike S L, van Lienden, Krijn P, Molenaar, I Quintus, Neumann, Ulf P, Patijn, Gijs A, Rijken, Arjen M, Ruers, Theo M, Verhoef, Cornelis, de Wilt, Johannes H W, Kazemier, Geert, May, Anne M, Punt, Cornelis J A, and Swijnenburg, Rutger-Jan

Published
2023

122. PERSPECTIVEs on supervised exercise programs in people with metastatic breast cancer- a qualitative study in four European countries

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Depenbusch, Johanna, Sweegers, Maike G, Aaronson, Neil K, Wengström, Yvonne, Backman, Malin, Arraras, Juan I, Schranz, Melanie, Büchler, Britta, Lachowicz, Milena, May, Anne M, Steindorf, Karen, Stuiver, Martijn M, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Depenbusch, Johanna, Sweegers, Maike G, Aaronson, Neil K, Wengström, Yvonne, Backman, Malin, Arraras, Juan I, Schranz, Melanie, Büchler, Britta, Lachowicz, Milena, May, Anne M, Steindorf, Karen, and Stuiver, Martijn M

Published
2023

123. Perceived facilitators and barriers by esophageal cancer survivors participating in a post-treatment exercise program

Author

Arts-assistenten Radiotherapie, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, van Vulpen, Jonna K, Witlox, Lenja, Methorst-de Haan, Alida C, Hiensch, Anouk E, van Hillegersberg, Richard, Ruurda, Jelle P, Nieuwenhuijzen, Grard A P, Kouwenhoven, Ewout A, Siersema, Peter D, May, Anne M, Arts-assistenten Radiotherapie, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Epi Kanker Team B, Cancer, MS CGO, Epi Kanker, van Vulpen, Jonna K, Witlox, Lenja, Methorst-de Haan, Alida C, Hiensch, Anouk E, van Hillegersberg, Richard, Ruurda, Jelle P, Nieuwenhuijzen, Grard A P, Kouwenhoven, Ewout A, Siersema, Peter D, and May, Anne M

Published
2023

124. EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing radical cystectomy: protocol of the ENHANCE multicentre randomised controlled trial

Author

MS Urologische Oncologie, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Akdemir, Emine, Sweegers, Maike G., Vrieling, Alina, Rundqvist, Helene, Meijer, Richard P., Leliveld-Kors, Annemarie M., Van Der Heijden, Antoine G., Rutten, Vera C., Koldewijn, Evert L., Bos, Siebe D., Wijburg, Carl J., Marcelissen, Tom A.T., Bongers, Bart C., Retèl, Valesca P., Van Harten, Wim H., May, Anne M., Groen, Wim G., Stuiver, Martijn M., MS Urologische Oncologie, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Akdemir, Emine, Sweegers, Maike G., Vrieling, Alina, Rundqvist, Helene, Meijer, Richard P., Leliveld-Kors, Annemarie M., Van Der Heijden, Antoine G., Rutten, Vera C., Koldewijn, Evert L., Bos, Siebe D., Wijburg, Carl J., Marcelissen, Tom A.T., Bongers, Bart C., Retèl, Valesca P., Van Harten, Wim H., May, Anne M., Groen, Wim G., and Stuiver, Martijn M.

Published
2023

125. The circadian clock remains intact, but with dampened hormonal output in heart failure

Author

Cardiologie, Pathologie Bachelor Research hub, Onderzoek Precision medicine, Arts Assistenten Cardiologie, Cardiologie Arts-onderzoekers, DIGD-Medisch 1, Circulatory Health, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Team Medisch, Regenerative Medicine and Stem Cells, Hart- en Vaatziekten Team A, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Onderzoek Cardiovasculair Reg. Med., Crnko, Sandra, Printezi, Markella I., Zwetsloot, Peter Paul M., Leiteris, Laurynas, Lumley, Andrew I., Zhang, Lu, Ernens, Isabelle, Jansen, Tijn P.J., Homsma, Lilian, Feyen, Dries, van Faassen, Martijn, du Pré, Bastiaan C., Gaillard, Carlo A.J.M., Kemperman, Hans, Oerlemans, Marish I.F.J., Doevendans, Pieter A.F.M., May, Anne M., Zuithoff, Nicolaas P.A., Sluijter, Joost P.G., Devaux, Yvan, van Laake, Linda W., Cardiologie, Pathologie Bachelor Research hub, Onderzoek Precision medicine, Arts Assistenten Cardiologie, Cardiologie Arts-onderzoekers, DIGD-Medisch 1, Circulatory Health, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Team Medisch, Regenerative Medicine and Stem Cells, Hart- en Vaatziekten Team A, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, Onderzoek Cardiovasculair Reg. Med., Crnko, Sandra, Printezi, Markella I., Zwetsloot, Peter Paul M., Leiteris, Laurynas, Lumley, Andrew I., Zhang, Lu, Ernens, Isabelle, Jansen, Tijn P.J., Homsma, Lilian, Feyen, Dries, van Faassen, Martijn, du Pré, Bastiaan C., Gaillard, Carlo A.J.M., Kemperman, Hans, Oerlemans, Marish I.F.J., Doevendans, Pieter A.F.M., May, Anne M., Zuithoff, Nicolaas P.A., Sluijter, Joost P.G., Devaux, Yvan, and van Laake, Linda W.

Published
2023

127. Exercise and Nutritional Interventions in Patients with Advanced Gastroesophageal Cancer: A Systematic Review

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Besseling, Joost, van Velzen, Merel, Wierdsma, Nicolette, Alonso-Duin, Kelly Silverio, Weijs, Peter, May, Anne M, van Laarhoven, Hanneke, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Besseling, Joost, van Velzen, Merel, Wierdsma, Nicolette, Alonso-Duin, Kelly Silverio, Weijs, Peter, May, Anne M, and van Laarhoven, Hanneke

Published
2023

128. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort

Author

Christakoudi, Sofia, Tsilidis, Konstantinos K., Muller, David C., Freisling, Heinz, Weiderpass, Elisabete, Overvad, Kim, Söderberg, Stefan, Häggström, Christel, Pischon, Tobias, Dahm, Christina C., Zhang, Jie, Tjønneland, Anne, Halkjær, Jytte, MacDonald, Conor, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Kaaks, Rudolf, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Cirera, Lluís, Barricarte-Gurrea, Aurelio, Amiano, Pilar, Memarian, Ensieh, Sonestedt, Emily, Bueno-de-Mesquita, Bas, May, Anne M., Khaw, Kay-Tee, Wareham, Nicholas J., Tong, Tammy Y. N., Huybrechts, Inge, Noh, Hwayoung, Aglago, Elom K., Ellingjord-Dale, Merete, Ward, Heather A., Aune, Dagfinn, and Riboli, Elio

Published
2020
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129. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Author

Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K., Banbury, Barbara, Martin, Richard M., Lewis, Sarah J., Kazmi, Nabila, Robinson, Timothy M., Albanes, Demetrius, Aleksandrova, Krasimira, Berndt, Sonja I., Timothy Bishop, D., Brenner, Hermann, Buchanan, Daniel D., Bueno-de-Mesquita, Bas, Campbell, Peter T., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Ellingjord-Dale, Merete, Figueiredo, Jane C., Gallinger, Steven J., Giles, Graham G., Giovannucci, Edward, Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A., Hoffmeister, Michael, Hopper, John L., Hsu, Li, María Huerta, José, Huyghe, Jeroen R., Jenkins, Mark A., Keku, Temitope O., Kühn, Tilman, La Vecchia, Carlo, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Lynch, Brigid, Markowitz, Sanford D., Masala, Giovanna, May, Anne M., Milne, Roger, Monninkhof, Evelyn, Moreno, Lorena, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Perduca, Vittorio, Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Riboli, Elio, Sánchez, Maria-Jose, Schmit, Stephanie L., Schoen, Robert E., Severi, Gianluca, Sieri, Sabina, Slattery, Martha L., Song, Mingyang, Tangen, Catherine M., Thibodeau, Stephen N., Travis, Ruth C., Trichopoulou, Antonia, Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Van Guelpen, Bethany, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Peters, Ulrike, Gunter, Marc J., and Murphy, Neil

Published
2020
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130. Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data

Author

VAN VULPEN, JONNA K., SWEEGERS, MAIKE G., PEETERS, PETRA H. M., COURNEYA, KERRY S., NEWTON, ROBERT U., AARONSON, NEIL K., JACOBSEN, PAUL B., GALVÃO, DANIEL A., CHINAPAW, MAI J., STEINDORF, KAREN, IRWIN, MELINDA L., STUIVER, MARTIJN M., HAYES, SANDI, GRIFFITH, KATHLEEN A., MESTERS, ILSE, KNOOP, HANS, GOEDENDORP, MARTINE M., MUTRIE, NANETTE, DALEY, AMANDA J., MCCONNACHIE, ALEX, BOHUS, MARTIN, THORSEN, LENE, SCHULZ, KARL-HEINZ, SHORT, CAMILLE E., JAMES, ERICA L., PLOTNIKOFF, RONALD C., SCHMIDT, MARTINA E., ULRICH, CORNELIA M., VAN BEURDEN, MARC, OLDENBURG, HESTER S., SONKE, GABE S., VAN HARTEN, WIM H., SCHMITZ, KATHRYN H., WINTERS-STONE, KERRI M., VELTHUIS, MIRANDA J., TAAFFE, DENNIS R., VAN MECHELEN, WILLEM, KERSTEN, MARIE JOSÉ, NOLLET, FRANS, WENZEL, JENNIFER, WISKEMANN, JOACHIM, VERDONCK-DE LEEUW, IRMA M., BRUG, JOHANNES, MAY, ANNE M., and BUFFART, LAURIEN M.

Published
2020
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132. The association of substituting carbohydrates with total fat and different types of fatty acids with mortality and weight change among diabetes patients

Author

Campmans-Kuijpers, Marjo J., Sluijs, Ivonne, Nöthlings, Ute, Freisling, Heinz, Overvad, Kim, Boeing, Heiner, Masala, Giovanna, Panico, Salvatore, Tumino, Rosario, Sieri, Sabina, Johansson, Ingegerd, Winkvist, Anna, Katzke, Verena A., Kuehn, Tilman, Nilsson, Peter M., Halkjær, Jytte, Tjønneland, Anne, Spijkerman, Annemieke M., Arriola, Larraitz, Sacerdote, Carlotta, Barricarte, Aurelio, May, Anne M., and Beulens, Joline W.

Published
2016
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136. Supplementary Data from Association of Anti-TNF with Decreased Survival in Steroid Refractory Ipilimumab and Anti-PD1–Treated Patients in the Dutch Melanoma Treatment Registry

Author

Verheijden, Rik J., primary, May, Anne M., primary, Blank, Christian U., primary, Aarts, Maureen J.B., primary, van den Berkmortel, Franchette W.P.J., primary, van den Eertwegh, Alfonsus J.M., primary, de Groot, Jan Willem B., primary, Boers-Sonderen, Marye J., primary, van der Hoeven, Jacobus J.M., primary, Hospers, Geke A., primary, Piersma, Djura, primary, van Rijn, Rozemarijn S., primary, ten Tije, Albert J., primary, van der Veldt, Astrid A.M., primary, Vreugdenhil, Gerard, primary, van Zeijl, Michiel C.T., primary, Wouters, Michel W.J.M., primary, Haanen, John B.A.G., primary, Kapiteijn, Ellen, primary, and Suijkerbuijk, Karijn P.M., primary

Published
2023
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137. EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing radical cystectomy: protocol of the ENHANCE multicentre randomised controlled trial

Author

Akdemir, Emine, primary, Sweegers, Maike G, additional, Vrieling, Alina, additional, Rundqvist, Helene, additional, Meijer, Richard P, additional, Leliveld-Kors, Annemarie M, additional, van der Heijden, Antoine G, additional, Rutten, Vera C, additional, Koldewijn, Evert L, additional, Bos, Siebe D, additional, Wijburg, Carl J, additional, Marcelissen, Tom A T, additional, Bongers, Bart C, additional, Retèl, Valesca P, additional, van Harten, Wim H, additional, May, Anne M, additional, Groen, Wim G, additional, and Stuiver, Martijn M, additional

Published
2023
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138. Association between classes and subclasses of polyphenol intake and 5‐year body weight changes in the EPIC‐PANACEA study

Author

Castañeda, Jazmin, primary, Gil‐Lespinard, Mercedes, additional, Almanza‐Aguilera, Enrique, additional, Llaha, Fjorida, additional, Gómez, Jesús‐Humberto, additional, Bondonno, Nicola, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Santucci de Magistris, Maria, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Skeie, Guri, additional, Brustad, Magritt, additional, Lasheras, Cristina, additional, Molina‐Montes, Esther, additional, Chirlaque, María‐Dolores, additional, Barricarte, Aurelio, additional, Sonestedt, Emily, additional, da Silva, Marisa, additional, Johansson, Ingegerd, additional, Hultdin, Johan, additional, May, Anne M., additional, Forouhi, Nita G., additional, Heath, Alicia K., additional, Freisling, Heinz, additional, Weiderpass, Elisabete, additional, Scalbert, Augustin, additional, and Zamora‐Ros, Raul, additional

Published
2023
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139. Moderators of exercise effects on self-reported cognitive functioning in cancer survivors:an individual participant data meta-analysis

Author

Hiensch, Anouk E., Beckhaus, Julia, Witlox, Lenja, Monninkhof, Evelyn M., Schagen, Sanne B., van Vulpen, Jonna K., Sweegers, Maike G., Newton, Robert U., Aaronson, Neil K., Galvão, Daniel A., Steindorf, Karen, Stuiver, Martijn M., Mesters, Ilse, Knoop, Hans, Goedendorp, Martine M., Bohus, Martin, Thorsen, Lene, Schulz, Karl-Heinz, Schmidt, Martina E., Ulrich, Cornelia M., Sonke, Gabe S., van Harten, Wim H., Winters-Stone, Kerri M., Velthuis, Miranda J., Taaffe, Dennis R., van Mechelen, Willem, Kersten, Marie José, Nollet, Frans, Wiskemann, Joachim, Buffart, Laurien M., May, Anne M., Master Evidence Based Practice, APH - Health Behaviors & Chronic Diseases, APH - Quality of Care, CCA - Cancer Treatment and Quality of Life, Medical Psychology, APH - Mental Health, Clinical Haematology, AII - Cancer immunology, CCA - Cancer biology and immunology, Rehabilitation medicine, AMS - Rehabilitation & Development, EURO-NMD, Public and occupational health, and APH - Societal Participation & Health

Subjects
Oncology (nursing), Survivorship, RANDOMIZED CONTROLLED-TRIAL, FATIGUE, Cognitive functioning, PROSTATE-CANCER, INCREASING PHYSICAL-ACTIVITY, ADJUVANT CHEMOTHERAPY, Sociology, Oncology, QUALITY-OF-LIFE, Individual participant data meta-analysis, ANDROGEN DEPRIVATION THERAPY, Human medicine, AEROBIC EXERCISE, HIGH-INTENSITY, Exercise, Biology, RESISTANCE, Cancer
Abstract

Purpose This individual participant data meta-analysis (IPD-MA) assesses exercise effects on self-reported cognitive functioning (CF) and investigates whether effects differ by patient-, intervention-, and exercise-related characteristics. Methods IPD from 16 exercise RCTs, including 1987 patients across multiple types of non-metastatic cancer, was pooled. A one-stage IPD-MA using linear mixed-effect models was performed to assess exercise effects on self-reported CF (z-score) and to identify whether the effect was moderated by sociodemographic, clinical, intervention- and exercise-related characteristics, or fatigue, depression, anxiety, and self-reported CF levels at start of the intervention (i.e., baseline). Models were adjusted for baseline CF and included a random intercept at study level to account for clustering of patients within studies. A sensitivity analysis was performed in patients who reported cognitive problems at baseline. Results Minimal significant beneficial exercise effects on self-reported CF (β=−0.09 [−0.16; −0.02]) were observed, with slightly larger effects when the intervention was delivered post-treatment (n=745, β=−0.13 [−0.24; −0.02]), and no significant effect during cancer treatment (n=1,162, β=−0.08 [−0.18; 0.02]). Larger effects were observed in interventions of 12 weeks or shorter (β=−0.14 [−0.25; −0.04]) or 24 weeks or longer (β=−0.18 [−0.32; −0.02]), whereas no effects were observed in interventions of 12–24 weeks (β=0.01 [−0.13; 0.15]). Exercise interventions were most beneficial when provided to patients without anxiety symptoms (β=−0.10 [−0.19; −0.02]) or after completion of treatment in patients with cognitive problems (β=−0.19 [−0.31; −0.06]). No other significant moderators were identified. Conclusions This cross-cancer IPD meta-analysis observed small beneficial exercise effects on self-reported CF when the intervention was delivered post-treatment, especially in patients who reported cognitive problems at baseline. Implications for Cancer Survivors This study provides some evidence to support the prescription of exercise to improve cognitive functioning. Sufficiently powered trials are warranted to make more definitive recommendations and include these in the exercise guidelines for cancer survivors.

Published
2023

141. Robot-assisted Minimally Invasive Thoracolaparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy for Resectable Esophageal Cancer: A Randomized Controlled Trial

Author

van der Sluis, Pieter C., van der Horst, Sylvia., May, Anne M., Schippers, Carlo, Brosens, Lodewijk A. A., Joore, Hans C. A., Kroese, Christiaan C., Haj Mohammad, Nadia, Mook, Stella, Vleggaar, Frank P., Borel Rinkes, Inne H. M., Ruurda, Jelle P., and van Hillegersberg, Richard

Published
2019
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143. Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)

Author

Ekelund, Ulf, Ward, Heather A, Norat, Teresa, Luan, Jian’an, May, Anne M, Weiderpass, Elisabete, Sharp, Stephen J, Overvad, Kim, Østergaard, Jane Nautrup, Tjønneland, Anne, Johnsen, Nina Føns, Mesrine, Sylvie, Fournier, Agnès, Fagherazzi, Guy, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Li, Kuanrong, Kaaks, Rudolf, Ferrari, Pietro, Licaj, Idlir, Jenab, Mazda, Bergmann, Manuela, Boeing, Heiner, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H, Monnikhof, Evelyn, Bueno-de-Mesquita, H Bas, Quirós, J Ramón, Agudo, Antonio, Sánchez, María-José, Huerta, José María, Ardanaz, Eva, Arriola, Larraitz, Hedblad, Bo, Wirfält, Elisabet, Sund, Malin, Johansson, Mattias, Key, Timothy J, Travis, Ruth C, Khaw, Kay-Tee, Brage, Søren, Wareham, Nicholas J, and Riboli, Elio

Published
2015
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145. Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort

Author

Gil-Lespinard, Mercedes, primary, Castañeda, Jazmín, additional, Almanza-Aguilera, Enrique, additional, Gómez, Jesús Humberto, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Overvad, Kim, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Santucci de Magistris, Maria, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Skeie, Guri, additional, Lasheras, Cristina, additional, Molina-Montes, Esther, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Sonestedt, Emily, additional, da Silva, Marisa, additional, Johansson, Ingegerd, additional, Hultdin, Johan, additional, May, Anne M., additional, Forouhi, Nita G., additional, Heath, Alicia K., additional, Freisling, Heinz, additional, Weiderpass, Elisabete, additional, Scalbert, Augustin, additional, and Zamora-Ros, Raul, additional

Published
2022
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146. Association of Immune-Related Adverse Event Management With Survival in Patients With Advanced Melanoma

Author

van Not, Olivier J., primary, Verheijden, Rik J., additional, van den Eertwegh, Alfonsus J. M., additional, Haanen, John B. A. G., additional, Aarts, Maureen J. B., additional, van den Berkmortel, Franchette W. P. J., additional, Blank, Christian U., additional, Boers-Sonderen, Marye J., additional, de Groot, Jan-Willem B., additional, Hospers, Geke A. P., additional, Kamphuis, Anna M., additional, Kapiteijn, Ellen, additional, May, Anne M., additional, de Meza, Melissa M., additional, Piersma, Djura, additional, van Rijn, Rozemarijn, additional, Stevense-den Boer, Marion A., additional, van der Veldt, Astrid A. M., additional, Vreugdenhil, Gerard, additional, Blokx, Willeke A. M., additional, Wouters, Michel J. M., additional, and Suijkerbuijk, Karijn P. M., additional

Published
2022
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149. External Validation of the Colon Life Nomogram for Predicting 12-Week Mortality in Dutch Metastatic Colorectal Cancer Patients Treated with Trifluridine/Tipiracil in Daily Practice

Author

Hamers, Patricia A. H., primary, Wensink, G. Emerens, additional, van Smeden, Maarten, additional, Vink, Geraldine R., additional, Smabers, Lidwien P., additional, Lunenberg, Renee A., additional, Laclé, Miangela M., additional, Koopman, Miriam, additional, May, Anne M., additional, and Roodhart, Jeanine M. L., additional

Published
2022
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