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649 results on '"Maurer, Konrad"'

105. Therapie des CRPS

Author

Maurer, Konrad, University of Zurich, Sprott, Haiko, and Maurer, Konrad

Subjects
10216 Institute of Anesthesiology, 610 Medicine & health
Published
2012

110. Spinal opioid receptor-sensitive muscle afferents contribute to the fatigue-induced increase in intracortical inhibition in healthy humans

Author

Hilty, L, Lutz, Kai, Maurer, Konrad, Rodenkirch, T, Spengler, Christina M, Boutellier, Urs, Jäncke, Lutz, Amann, M, University of Zurich, and Amann, M

Subjects
2737 Physiology (medical), 10093 Institute of Psychology, 10216 Institute of Anesthesiology, 570 Life sciences, biology, 2916 Nutrition and Dietetics, 610 Medicine & health, 1314 Physiology, 150 Psychology, 10052 Institute of Physiology
Published
2011

118. Abnormal Connectional Fingerprint in Schizophrenia: A Novel Network Analysis of Diffusion Tensor Imaging Data.

Author

Thanarajah, Sharmili Edwin, Han, Cheol E., Rotarska-Jagiela, Anna, Singer, Wolf, Deichmann, Ralf, Maurer, Konrad, Kaiser, Marcus, and Uhlhaas, Peter J.

Subjects
SCHIZOTYPAL personality disorder, HUMAN fingerprints
Abstract

The graph theoretical analysis of structural magnetic resonance imaging (MRI) data has received a great deal of interest in recent years to characterize the organizational principles of brain networks and their alterations in psychiatric disorders, such as schizophrenia. However, the characterization of networks in clinical populations can be challenging, since the comparison of connectivity between groups is influenced by several factors, such as the overall number of connections and the structural abnormalities of the seed regions. To overcome these limitations, the current study employed the whole-brain analysis of connectional fingerprints in diffusion tensor imaging data obtained at 3 T of chronic schizophrenia patients (n = 16) and healthy, age-matched control participants (n = 17). Probabilistic tractography was performed to quantify the connectivity of 110 brain areas. The connectional fingerprint of a brain area represents the set of relative connection probabilities to all its target areas and is, hence, less affected by overall white and gray matter changes than absolute connectivity measures. After detecting brain regions with abnormal connectional fingerprints through similarity measures, we tested each of its relative connection probability between groups. We found altered connectional fingerprints in schizophrenia patients consistent with a dysconnectivity syndrome. While the medial frontal gyrus showed only reduced connectivity, the connectional fingerprints of the inferior frontal gyrus and the putamen mainly contained relatively increased connection probabilities to areas in the frontal, limbic, and subcortical areas. These findings are in line with previous studies that reported abnormalities in striatal-frontal circuits in the pathophysiology of schizophrenia, highlighting the potential utility of connectional fingerprints for the analysis of anatomical networks in the disorder. [ABSTRACT FROM AUTHOR]

Published
2016
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121. P 300 asymmetries in schizophrenia revisited with reference-independent methods

Author

Strik, Werner K., Dierks, Thomas, Franzek, Ernst, Stöber, Gerald, and Maurer, Konrad

Subjects
ddc:150, Schizophrenie
Abstract

Evidence of hemispheric asymmetries in schizophrenia has been reported from different research areas. Asymmetries in evoked potential P300 topography are still controversial because of inconsistent findings. In the present study. previous results of abnormal lateralization of P300 were replicated in stabilized residual Schizophrenie patients. Auditory P300 was recorded during an odd ball task in which subjeets detected rare target stimuli. Schizophrenie patients had the P300 peak shifted to the right hemisphere and differed signifieantly from age- and sex-matched normal control subjects who had left-lateralized P300 peaks. A comparison of different methods of assessment and analysis of the topographical features of the P300 electric fields showed that the extraction of reference-independent descriptors of P300 topography is a reliable and sensitive method for statistical handling of the maps. The results suggest left hemispheric dysfunction during cognitive tasks in a subgroup of Schizophrenie patients. Inconsistencies between previous sturlies are likely to be due to heterogeneous patient groups, which may have included patients in an acute Schizophrenie episode or patients in clinical remission. lnvestigation of the clinical meaning of P300 alterations requires careful psychopathological definition of the patient groups.

Published
1994

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