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1,232 results on '"Matsumoto, Masayasu"'

103. Low-Dose Aspirin for Prevention of Stroke in Low-Risk Patients With Atrial Fibrillation: Japan Atrial Fibrillation Stroke Trial

Author

Sato, Hiroshi, Ishikawa, Kinji, Kitabatake, Akira, Ogawa, Satoshi, Maruyama, Yukio, Yokota, Yoshiyuki, Fukuyama, Takaya, Doi, Yoshinori, Mochizuki, Seibu, Izumi, Tohru, Takekoshi, Noboru, Yoshida, Kiyoshi, Hiramori, Katsuhiko, Origasa, Hideki, Uchiyama, Shinichiro, Matsumoto, Masayasu, Yamaguchi, Takenori, and Hori, Masatsugu

Published
2006
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106. Functional Neuroanatomy of Writing Revealed by 3D PET

Author

Oku, Naohiko, primary, Hashikawa, Kazuo, additional, Matsumoto, Masayasu, additional, Yamamoto, Haruko, additional, Seike, Yujiro, additional, Nukata, Masaru, additional, Nishimura, Hiroshi, additional, Teratani, Tadanori, additional, Hori, Masatsugu, additional, and Nishimura, Tsunehiko, additional

Published
2001
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107. Delayed neuronal death in ischemic hippocampus involves stimulation of protein tyrosine phosphorylation

Author

Toshiho, Ohtsuki, Matsumoto, Masayasu, Kitagawa, Kazuo, Mabuchi, Takuma, Mandai, Kenji, Matsushita, Kohji, Kuwabara, Keisuke, Tagaya, Masafumi, Ogawa, Satoshi, Ueda, Hirokazu, Kamada, Takenobu, and Yanagihara, Takehiko

Subjects
Cerebral ischemia -- Physiological aspects, Protein tyrosine kinase -- Physiological aspects, Cell death -- Physiological aspects, Neurons -- Physiological aspects, Phosphorylation -- Physiological aspects, Cellular signal transduction -- Physiological aspects, Biological sciences
Abstract

Tyrosine kinase acts as a messenger of neuronal cell death during the selective degeneration of hippocampal pyramid cells in transient forebrain ischemia models. Protein tyrosine phosphorylation of pp42 was detected after the nonlethal and lethal ischemia of the hippocampus and cerebral cortex. The ischemic hippocampal CA1 neurons also exhibited increased expression of phosphotyrosyl proteins indicating the anti-microtubule-associated protein kinase activity of pp42.

Published
1996

114. Mitochondrial lipid peroxidation and superoxide dismutase in rat hypertensive target organs

Author

Ohtsuki, Toshiho, Matsumoto, Masayasu, Suzuki, Keiichiro, Taniguchi, Naoyuki, and Kamada, Takenobu

Subjects
Superoxide dismutase -- Physiological aspects, Hypertension -- Research, Acetates -- Physiological aspects, Active oxygen in the body -- Analysis, Biological sciences
Abstract

Mitochondrial misuse of oxygen in the brain during hypertension may result in mitochondrial injury and neuron degeneration, as shown by hypertensive rats. Mitochondrial thiobarbituric acid-reactive substance (TBARS) and manganese superoxide dismutase (MnSOD) concentration in hyper tensive target organs (heart, brain and kidney) of spontaneously hypertensive rats (SHR) is analysed. TBARS and MnSOD in brain increased noticeably in rats during maturation. Marked increase of lipid peroxidation is observed in SHR but no increase in MnSOD in the brain is noticed.

Published
1995

115. Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain

Author

Ohtsuki, Toshiho, Matsumoto, Masayasu, Hayashi, Yoko, Yamamoto, Kei, Kitagawa, Kazuo, Ogawa, Satoshi, Yamamoto, Shozo, and Kamada, Takenobu

Subjects
Reperfusion injury -- Research, Gerbils -- Research, Biological sciences
Abstract

The influence exerted by 5minutes of ischemia on brain 5-lipoxygenase (5-LO) and leukotriene C4 (LTC4) is investigated during reperfusion. The gerbil model of transient forebrain ischemia is used in the investigation. The investigation reveals that during reperfusion the production of LTC4 is reduced by superoxide dismutase and oxygen radical scavengers.

Published
1995

124. Association of Timing for Starting Dual Antiplatelet Treatment With Cilostazol and Recurrent Stroke

Author

Toyoda, Kazunori, Omae, Katsuhiro, Hoshino, Haruhiko, Uchiyama, Shinichiro, Kimura, Kazumi, Miwa, Kaori, Minematsu, Kazuo, Yamaguchi, Keiji, Suda, Yoshitaka, Toru, Shuta, Kitagawa, Kazuo, Ihara, Masafumi, Koga, Masatoshi, Yamaguchi, Takenori, Yamaguchi, Takenori, Uchiyama, Shinichiro, Toyoda, Kazunori, Naritomi, Hiroaki, Minematsu, Kazuo, Orikasa, Hideki, Hoshino, Haruhiko, Kimura, Kazumi, Okada, Yasushi, Sakai, Nobuyuki, Tanaka, Kotaro, Goto, Shinya, Isomura, Tatsuya, Houkin, Kiyohiro, Matsumoto, Masayasu, Terayama, Yasuo, Tomimoto, Hidekazu, Tominaga, Teiji, Yasuda, Satoshi, Kumagai, Naoko, Yamaguchi, Keiji, Isobe, Masanori, Suda, Yoshitaka, Kitagawa, Kazuo, Nagatsuka, Kazuyuki, Toru, Shuta, Katsuno, Makoto, Sakai, Nobuyuki, Murao, Kenichi, Ikeda, Norio, Nakashima, Kazuya, Okabe, Shinichi, Kurimoto, Masanori, Ihara, Ikuo, Matsuoka, Hideki, Mabuchi, Shoji, Hara, Hideo, Yoshimoto, Tetsuyuki, Matsuoka, Takeshi, and Arai, Yoshikazu

Published
2022
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136. DS_10.1369_0022155418793600 – Supplemental material for 4′,6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits

Author

Chengyu Li, Takahashi, Tetsuya, Tejashwi Shrestha, Kinoshita, Eiji, Tomoyasu Matsubara, Matsumoto, Masayasu, and Maruyama, Hirofumi

Subjects
FOS: Biological sciences, FOS: Clinical medicine, Cell Biology, 69999 Biological Sciences not elsewhere classified, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, DS_10.1369_0022155418793600 for 4′,6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits by Chengyu Li, Tetsuya Takahashi, Tejashwi Shrestha, Eiji Kinoshita, Tomoyasu Matsubara, Masayasu Matsumoto and Hirofumi Maruyama in Journal of Histochemistry & Cytochemistry

Published
2018
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137. Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan: a multicentre, open-label, randomised controlled trial

Author

Toyoda, Kazunori, primary, Uchiyama, Shinichiro, additional, Yamaguchi, Takenori, additional, Easton, J Donald, additional, Kimura, Kazumi, additional, Hoshino, Haruhiko, additional, Sakai, Nobuyuki, additional, Okada, Yasushi, additional, Tanaka, Kortaro, additional, Origasa, Hideki, additional, Naritomi, Hiroaki, additional, Houkin, Kiyohiro, additional, Yamaguchi, Keiji, additional, Isobe, Masanori, additional, Minematsu, Kazuo, additional, Goto, Shinya, additional, Isomura, Tatsuya, additional, Matsumoto, Masayasu, additional, Terayama, Yasuo, additional, Tomimoto, Hidekazu, additional, Tominaga, Teiji, additional, Yasuda, Satoshi, additional, and Kumagai, Naoko, additional

Published
2019
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138. Physiological parameters of cerebral small-vessel disease

Author

DOIJIRI, Ryosuke, primary, SAITO, Kozue, additional, UCHIYAMA, Shinichiro, additional, KITAGAWA, Kazuo, additional, TAKEKAWA, Hidehiro, additional, TADOKORO, Yasuhiro, additional, TSUTSUMI, Yukiko, additional, FUJISHIRO, Kentaro, additional, MATSUMOTO, Masayasu, additional, YAMAMURA, Osamu, additional, and NAGATSUKA, Kazuyuki, additional

Published
2019
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142. Severe brain atrophy after long-term survival seen in siblings with familial amyotrophic lateral sclerosis and a mutation in the optineurin gene: a case series

Author

Ueno Hiroki, Kobatake Keitaro, Matsumoto Masayasu, Morino Hiroyuki, Maruyama Hirofumi, and Kawakami Hideshi

Subjects
Medicine
Abstract

Abstract Introduction Previous studies have shown widespread multisystem degeneration in patients with sporadic amyotrophic lateral sclerosis who develop a total locked-in state and survive under mechanical ventilation for a prolonged period of time. However, the disease progressions reported in these studies were several years after disease onset. There have been no reports of long-term follow-up with brain imaging of patients with familial amyotrophic lateral sclerosis at an advanced stage of the disease. We report the cases of siblings with amyotrophic lateral sclerosis with homozygous deletions of the exon 5 mutation of the gene encoding optineurin, in whom brain computed tomography scans were followed up for more than 20 years. Case presentation The patients were a Japanese brother and sister. The elder sister was 33 years of age at the onset of disease, which began with muscle weakness of her left lower limb. Two years later she required mechanical ventilation. She became bedridden at the age of 34, and died at the age of 57. A computed tomography scan of her brain at the age of 36 revealed no abnormality. Atrophy of her brain gradually progressed. Ten years after the onset of mechanical ventilation, atrophy of her whole brain, including the cerebral cortex, brain stem and cerebellum, markedly progressed. Her younger brother was 36 years of age at the onset of disease, which presented as muscle weakness of his left upper limb. One year later, he showed dysphagia and dysarthria, and tracheostomy ventilation was performed. He became bedridden at the age of 37 and died at the age of 55. There were no abnormal intracranial findings on brain computed tomography scans obtained at the age of 37 years. At the age of 48 years, computed tomography scans showed marked brain atrophy with ventricular dilatation. Subsequently, atrophy of the whole brain rapidly progressed as in his elder sister. Conclusion We conclude that a homozygous deletion-type mutation in the optineurin gene may be associated with widespread multisystem degeneration in amyotrophic lateral sclerosis.

Published
2011
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145. The pathophysiology of prospective memory failure after diffuse axonal injury - Lesion-symptom analysis using diffusion tensor imaging

Author

Hashimoto Yukari, Sawada Kozue, Ueno Hiroki, Maruishi Masaharu, Kondo Keita, Ohshita Tomohiko, Takahashi Tetsuya, Ohtsuki Toshiho, and Matsumoto Masayasu

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Prospective memory (PM) is one of the most important cognitive domains in everyday life. The neuronal basis of PM has been examined by a large number of neuroimaging and neuropsychological studies, and it has been suggested that several cerebral domains contribute to PM. For these activation studies, a constellation of experimental PM trials was developed and adopted to healthy subjects. In the present study, we used a widely used clinical PM assessment battery to determine the lesions attributable to PM failure, with the hypothesis that lesion-symptom analysis using diffusion tensor imaging (DTI) in subjects with diffuse axonal injury (DAI) can reveal the neuronal basis of PM in everyday life. Results Fourteen DAI patients (age: range of 18-36, median 24) participated in this study. PM failure was scored in the range of 0-6 using three sub-tests of the Rivermead Behavioural Memory Test. The PM scores of DAI patients were in the range of 2-6 (median 4.5, inter-quartile range 2.25). The severity of axonal injury following DAI was examined using fractional anisotropy (FA), one of the DTI parameters, at voxel level in each subject. We then obtained clusters correlated with PM failure by conducting voxel-based regression analysis between FA values and PM scores. Three clusters exhibited significant positive correlation with PM score, the left parahippocampal gyrus, left inferior parietal lobe, and left anterior cingulate. Conclusions This is the first lesion-symptom study to reveal the neuronal basis of PM using DTI on subjects with DAI. Our findings suggest that the neuronal basis of PM is in the left parahippocampal gyrus, left inferior parietal lobe, and/or left anterior cingulate. These findings are similar to those of previous activation studies with loading experimental PM tasks.

Published
2010
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