381 results on '"Masjuan, Jaime"'
Search Results
102. Outcomes measured by mortality rates, quality of life and degree of autonomy in the first year in stroke units in Spain
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Mar, Javier, Masjuan, Jaime, Oliva-Moreno, Juan, Gonzalez-Rojas, Nuria, Becerra, Virginia, Casado, Miguel Ángel, Torres, Covadonga, Yebenes, María, Quintana, Manuel, Alvarez-Sabín, Jose, Universitat Autònoma de Barcelona, and CONOCES Investigators Group
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Male ,Quality of life ,medicine.medical_specialty ,Health Status ,medicine.medical_treatment ,Outcomes ,Logistic regression ,Risk Assessment ,Outcome Assessment (Health Care) ,Modified Rankin Scale ,Outcome Assessment, Health Care ,Humans ,Medicine ,cardiovascular diseases ,Stroke ,Aged ,Disability ,Rehabilitation ,Receiver operating characteristic ,business.industry ,Research ,Mortality rate ,Public Health, Environmental and Occupational Health ,Recovery of Function ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Thrombolysis ,Stroke units ,Logistic Models ,Treatment Outcome ,Spain ,Personal Autonomy ,Physical therapy ,Female ,Risk assessment ,business - Abstract
Altres ajuts: The study has been funded by an unrestricted grant from Boehringer Ingelheim Spain. The primary objective of this sub analysis of the CONOCES study was to analyse outcomes in terms of mortality rates, quality of life and degree of autonomy over the first year in patients admitted to stroke units in Spain. The secondary objective was to identify the factors determining good prognosis. We studied a sample of patients who had suffered a confirmed stroke and been admitted to a Stroke Unit in the Spanish healthcare system. Socio-demographic and clinical variables and variables related to the level of severity (NIHSS), the level of autonomy (Barthel, modified Rankin) and quality of life (EQ-5D) were recorded at the time of admission and then three months and one year after the event. Factors determining prognosis were analysed using logistic regression and ROC curves. A total of 321 patients were recruited, 33% of whom received thrombolytic treatment, which was associated with better results on the Barthel and the modified Rankin scales and in terms of the risk of death. Mean quality of life measured through EQ-5D improved from 0.57 at discharge to 0.65 one year later. Full autonomy level measured by Barthel index increased from 30.1% at discharge to 52.8% at one year and by the modified Rankin scale from 51% to 71%. The rates for in-hospital and 1-year mortality were 5.9% and 17.4% respectively. Low NIHSS scores were associated with a good prognosis with all the outcome variables. The three instruments applied (NIHSS, Barthel and modified Rankin scales) on admission showed good discriminative ability for patient prognosis in the ROC curves. There has been a change in the prognosis for stroke in Spain in recent years as the quality of life at 1 year observed in our study is clearly higher than that obtained in other Spanish studies conducted previously. Moreover, survival and functional outcome have also improved following the introduction of a new model of care. These results clearly promote extension of the model based on stroke units and reinforced rehabilitation to the majority of the more than 100,000 strokes that occur annually in Spain.
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- 2015
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103. Opsoclonus–myoclonus syndrome and limbic encephalitis associated with GABAB receptor antibodies in CSF
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DeFelipe-Mimbrera, Alicia, Masjuan, Jaime, Corral, Íñigo, Villar, Luisa Maria, Graus, Francesc, and García-Barragán, Nuria
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- 2014
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104. Clot migration in patients treated with tenecteplase versus alteplase before mechanical thrombectomy
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García-Alcántara, Gabriel, Moreno-López, Cristina, López-Rebolledo, Rodrigo, Lorenzo-Barreto, Pablo, Garay-Albízuri, Patricia, Martínez-García, Beatriz, Llanes, Ana, Pérez-Gil, Daniel, Chico, Juan Luis, Vera-Lechuga, Rocío, García-Madrona, Sebastián, Matute-Lozano, Consuelo, De Felipe-Mimbrera, Alicia, Masjuan, Jaime, and Cruz-Culebras, Antonio
- Abstract
Introduction: This study aimed to describe and analyze the rate of clot migration of vessel thrombosis to distal segments in patients with acute ischemic stroke (AIS) who received intravenous thrombolysis (IVT) with tenecteplase (TNK) and alteplase (ALT) before mechanical thrombectomy (MT). In addition, we aimed to determine the relationship between thrombus migration and functional prognosis.Methods: This study followed the STROBE reporting guidelines. We performed a retrospective analysis of a series of patients from November 2017 to April 2023 with an AIS with thrombosis on CT imaging, treated with IVT (TNK or ALT, split into two distinct groups) prior to mechanical thrombectomy.Results: Two hundred and fifty-six patients with large vessel occlusion (LVO) were included. Ninety-six had received TNK. One hundred and sixty had received ALT. Of the 96 TNK patients, 25 experienced either complete recanalization (n= 3) or thrombus migration (n= 22). Of the 160 ALT patients, 20 experienced either complete recanalization (n= 6) or thrombus migration (n= 14). The difference being statistically substantial for the thrombus migration rate (OR = 3.61, 95% confidence interval: 1.63; 7.98). Migration to an irretrievable very distal segment occurred in four (4%) patients with TNK and in three patients (2%) with ALT (p> 0.05). Thrombus migration was not significantly associated to a different functional prognosis, measured through Rankin scale after 3 months (OR = 0.44, 95% confidence interval: 0.17; 1.12).Conclusion: The use of TNK over ALT as a fibrinolytic agent is associated with a higher thrombus migration rate. The migration of thrombi to distal segments, which are theoretically less accessible for mechanical thrombectomy, did not result in worse clinical outcomes.
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- 2024
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105. Secondary prevention in non-valvular atrial fibrillation patients: a practical approach with edoxaban
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Masjuan, Jaime, primary and DeFelipe, Alicia, additional
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- 2016
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106. En el camino de un mejor uso de los anticoagulantes en la fibrilación auricular no valvular. Propuesta de modificación del posicionamiento terapéutico UT/V4/23122013
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Roldán, Inmaculada, primary, Marín, Francisco, additional, Roldán, Inmaculada, additional, Tello-Montoliu, Antonio, additional, Roldán, Vanessa, additional, Anguita, Manuel, additional, Ruiz Nodar, Juan Miguel, additional, Íñiguez, Andrés, additional, González Juanatey, José Ramón, additional, Rodríguez Padial, Luis, additional, Badimón, Lina, additional, Mateo, José, additional, Vicente, Vicente, additional, Gallego Culleré, Jaime, additional, Masjuan, Jaime, additional, González-Armengol, Juan J., additional, Marín-Martínez, Alfonso, additional, Coll-Vinent i Puig, Blanca, additional, Casariego-Vales, Emilio, additional, Llisterri-Caro, José Luis, additional, Polo-García, José, additional, and Rodríguez-Roca, Gustavo C., additional
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- 2016
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107. Mechanical thrombectomy in orally anticoagulated patients with acute ischemic stroke.
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Zapata-Wainberg, Gustavo, Ximénez-Carrillo, Álvaro, Trillo, Santiago, Fuentes, Blanca, Cruz-Culebras, Antonio, Aguirre, Clara, de Leciñana, María Alonso, Vera, Rocío, Bárcena, Eduardo, Fernández-Prieto, Andrés, Méndez-Cendón, José Carlos, Caniego, Jose Luis, Díez-Tejedor, Exuperio, Masjuan, Jaime, and Vivancos, José
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ANTICOAGULANTS ,CEREBRAL hemorrhage ,STROKE-related mortality ,CEREBRAL ischemia ,LONGITUDINAL method ,MEDICAL cooperation ,ORAL drug administration ,RESEARCH ,STROKE ,THROMBOLYTIC therapy ,THROMBOSIS ,VEIN surgery ,VITAMIN K ,RETROSPECTIVE studies ,STROKE patients ,CHEMICAL inhibitors ,DISEASE risk factors - Abstract
Background and purpose To investigate the efficacy and safety of mechanical thrombectomy in patients with acute ischemic stroke according to the oral anticoagulation medication taken at the time of stroke onset. Materials and methods A retrospective multicenter study of prospectively collected data based on data from the registry the Madrid Stroke Network was performed. We included consecutive patients with acute ischemic stroke treated with mechanical thrombectomy and compared the frequency of intracranial hemorrhage and the modified Rankin Scale (mRS) score at 3 months according to anticoagulation status. Results The study population comprised 502 patients, of whom 389 (77.5%) were not anticoagulated, 104 (20.7%) were taking vitamin K antagonists, and 9 (1.8%) were taking direct oral anticoagulants. Intravenous thrombolysis had been performed in 59.8% and 15.0% of non-anticoagulated and anticoagulated patients, respectively. Rates of intracranial hemorrhage after treatment were similar between non-anticoagulated and anticoagulated patients, as were rates of recanalization. After 3 months of follow-up, the mRS score was ≤2 in 56.3% and 55.7% of non-anticoagulated and anticoagulated patients, respectively (P=NS). Mortality rates were similar in the two groups (13.1%and12.4%, respectively). Among anticoagulated patients, no differences were found for intracranial bleeding, mRS score, or mortality rates between patients taking vitamin K antagonists and those taking direct oral anticoagulants. Conclusions Mechanical thrombectomy is feasible in anticoagulated patients with acute ischemic stroke. The outcomes and safety profile are similar to those of patients with no prior anticoagulation therapy. [ABSTRACT FROM AUTHOR]
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- 2018
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108. Abstract W P143: Ankle-brachial Index Predicts Extracranial Vascular Events After Transient Ischemic Attacks. Data From The Promapa Study
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Purroy, Francisco, primary, Porta, Sara, additional, Jiménez-Caballero, Pedro E, additional, Jirón, Juan María, additional, Gorospe, Arantxa, additional, Torres, María José, additional, Jiménez-Caballero, Carmen, additional, Martínez-Sánchez, Patricia, additional, Martí-Fábregas, Joan, additional, García-Pastor, Antonio, additional, Casado-Naranjo, Ignacio, additional, Ramírez-Moreno, José María, additional, Segura, Tomás, additional, and Masjuan, Jaime, additional
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- 2015
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109. Sonography for Diagnosis of Parkinson Disease-From Theory to Practice
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Alonso-Cánovas, Araceli, primary, López-Sendón, José Luis, additional, Buisán, Javier, additional, deFelipe-Mimbrera, Alicia, additional, Guillán, Marta, additional, García-Barragán, Nuria, additional, Corral, Iñigo, additional, Matute-Lozano, María Consuelo, additional, Masjuan, Jaime, additional, Martínez-Castrillo, Juan Carlos, additional, and Walter, Uwe, additional
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- 2014
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110. Bilateral optic neuritis and Guillain-Barre syndrome following an acute Mycoplasma pneumoniae infection
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Ginestal, Ricardo C., Plaza, Jose F., Callejo, Juan Manuel, Rodriguez-Espinosa, Norberto, Fernandez-Ruiz, Luis Carlos, and Masjuan, Jaime
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Optic neuritis -- Risk factors ,Guillain-Barre syndrome -- Risk factors ,Mycoplasma infections -- Complications and side effects ,Health - Abstract
Byline: Ricardo C. Ginestal (1), Jose F. Plaza (1), Juan Manuel Callejo (1), Norberto Rodriguez-Espinosa (1), Luis Carlos Fernandez-Ruiz (1), Jaime Masjuan (1) Author Affiliation: (1) Servicio de Neurologia, Hospital Ramon y Cajal, 28034, Madrid, Spain Article History: Registration Date: 01/01/2004 Received Date: 23/07/2003 Accepted Date: 12/02/2004
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- 2004
111. Secondary prevention in non-valvular atrial fibrillation patients: a practical approach with edoxaban.
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Masjuan, Jaime and DeFelipe, Alicia
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ATRIAL fibrillation prevention , *TRANSIENT ischemic attack , *BLOOD coagulation , *VITAMIN K , *HEMORRHAGE , *EDOXABAN - Abstract
Patients with atrial fibrillation and prior stroke or transient ischemic attack exhibit a very high risk of recurrence. Secondary prevention with oral anticoagulants is mandatory. Overall, clinical guidelines recommend the use of target-specific oral anticoagulants over vitamin K antagonists for secondary prevention of stroke in patients with atrial fibrillation. However, many patients with atrial fibrillation and previous stroke are not receiving the appropriate antithrombotic treatment, perhaps due to the perceived risks of anticoagulation including the risk of hemorrhagic transformation of an ischemic stroke. The ENGAGE AF-TIMI 48 trial showed that although edoxaban 60 mg and warfarin reduced the risk of stroke to a similar extent, edoxaban exhibited a lesser risk of bleeding, particularly intracranial hemorrhage. Importantly, these data were independent of the presence of prior stroke or transient ischemic attack. Therefore, edoxaban can be used in both primary and secondary prevention of stroke in patients with non-valvular atrial fibrillation. The aim of this review was to update the available evidence about edoxaban in the clinical management of secondary prevention in individuals with non-valvular atrial fibrillation. [ABSTRACT FROM AUTHOR]
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- 2017
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112. Abstract T P185: Effectiveness Of A Telestroke System In A Metropolitan Area: A Prospective Cohort Study. The Madrid Telestroke Project
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Martinez-Sanchez, Patricia, primary, Alonso de Leciñana, María, additional, Miralles-Martínez, Ambrosio, additional, Huertas-Gonzalez, Nuria, additional, Martín-Martínez, Alfonso, additional, Correas-Callero, Elisa, additional, Sanz de Barros, Rosa, additional, Domingo-García, Julio, additional, Serrano-López, Soledad, additional, Fuentes, Blanca, additional, Masjuan, Jaime, additional, Ruiz-Ares, Gerardo, additional, Martinez-Martinez, Marta, additional, Sanz-Cuesta, Borja E, additional, Cruz-Herranz, Andrés, additional, and Díez-Tejedor, Exuperio, additional
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- 2014
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113. Successful intravenous thrombolysis in acute ischaemic stroke in a patient on rivaroxaban treatment
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Alonso-Canovas, Araceli, primary, Mimbrera, Alicia de Felipe, primary, Maza, Susana Sainz de la, primary, Alvarez-Velasco, Rodrigo, primary, Zarza, Beatriz, primary, Masjuan, Jaime, primary, and Kawiorski, Michal Maciej, additional
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- 2014
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114. Dabigatran in Secondary Stroke Prevention: Clinical Experience with 106 Patients
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DeFelipe-Mimbrera, Alicia, primary, Cánovas, Araceli Alonso, additional, Guillán, Marta, additional, Matute, Consuelo, additional, Sainz de la Maza, Susana, additional, Cruz, Antonio, additional, Vera, Rocío, additional, and Masjuan, Jaime, additional
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- 2014
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115. Factores asociados al mal control de la anticoagulación con antivitaminaK en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN
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Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., Suárez Fernández, C., Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, and Rivera., José M.
- Abstract
Identificar los factores asociados con el mal control de la anticoagulación con antagonistas de la vitaminaK (AVK) en pacientes con fibrilación auricular no valvular (FANV) atendidos en consultas de Neurología y Medicina Interna de España.
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- 2018
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116. Acute Ischemic Stroke in a 12-Year-Old Successfully Treated With Mechanical Thrombectomy
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Maza, Susana Sainz de la, primary, Felipe, Alicia De, additional, Matute, Maria Consuelo, additional, Fandiño, Eduardo, additional, Méndez, José Carlos, additional, Morillo, Pablo, additional, and Masjuan, Jaime, additional
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- 2013
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117. Novedades en la prevención secundaria del ictus cardioembólico
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Masjuan, Jaime, primary
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- 2012
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118. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)
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Dávalos, Antoni, primary, Alvarez-Sabín, José, additional, Castillo, José, additional, Díez-Tejedor, Exuperio, additional, Ferro, Jose, additional, Martínez-Vila, Eduardo, additional, Serena, Joaquín, additional, Segura, Tomás, additional, Cruz, Vitor T, additional, Masjuan, Jaime, additional, Cobo, Erik, additional, and Secades, Julio J, additional
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- 2012
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119. Intravenous Thrombolytic Treatment in the Oldest Old
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García-Caldentey, Juan, primary, Alonso de Leciñana, María, additional, Simal, Patricia, additional, Fuentes, Blanca, additional, Reig, Gemma, additional, Díaz-Otero, Fernando, additional, Guillán, Marta, additional, García, Ana, additional, Martínez, Patricia, additional, García-Pastor, Andrés, additional, Egido, José Antonio, additional, Díez-Tejedor, Exuperio, additional, Gil-Núñez, Antonio, additional, Vivancos, José, additional, and Masjuan, Jaime, additional
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- 2012
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120. Thrombolytic Therapy for Acute Ischemic Stroke after Recent Transient Ischemic Attack
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de Leciñana, María Alonso, primary, Fuentes, Blanca, additional, Masjuan, Jaime, additional, Simal, Patricia, additional, Díaz-Otero, Fernando, additional, Reig, Gemma, additional, Díez-Tejedor, Exuperio, additional, Gil-Nuñez, Antonio, additional, Vivancos, Jose, additional, and Egido, Jose-Antonio, additional
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- 2011
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121. Infartos cerebrales intrahospitalarios: datos del registro multicéntrico de pacientes con infarto cerebral ingresados en Cardiología y Cirugía Cardiaca
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Vera, Rocío, primary, Lago, Aída, additional, Fuentes, Blanca, additional, Gállego, Jaime, additional, Tejada, Javier, additional, Casado, Ignacio, additional, Purroy, Francisco, additional, Delgado, Pilar, additional, Simal, Patricia, additional, Martí-Fábregas, Joan, additional, Vivancos, José, additional, Díaz-Otero, Fernando, additional, Freijo, Mar, additional, Díez-Tejedor, Exuperio, additional, Gil-Núñez, Antonio, additional, Egido, Jose, additional, Reig, Gemma, additional, Calle, María Luisa, additional, de Leciñana, María Alonso, additional, and Masjuan, Jaime, additional
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- 2011
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122. Thrombolysis treatment for acute ischaemic stroke in a patient on treatment with dabigatran
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Matute, María Consuelo, additional, Guillán, Marta, additional, García-Caldentey, Juan, additional, Buisán, Javier, additional, Aparicio, María, additional, Masjuan, Jaime, additional, and Leciñana, María Alonso de, additional
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- 2011
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123. Familial amyloid polyneuropathy associated with TTRSer50Arg mutation in two Iberian families presenting a novel single base change in the mutant gene
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Munar-Qués, Miguel, primary, Masjuan, Jaime, additional, Coelho, Teresa, additional, Moreira, Paul, additional, Viader-Farré, Carlos, additional, and Saraiva, María J. M., additional
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- 2007
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124. Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma
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Dalmau, Josep, primary, Tüzün, Erdem, additional, Wu, Hai‐yan, additional, Masjuan, Jaime, additional, Rossi, Jeffrey E., additional, Voloschin, Alfredo, additional, Baehring, Joachim M., additional, Shimazaki, Haruo, additional, Koide, Reiji, additional, King, Dale, additional, Mason, Warren, additional, Sansing, Lauren H., additional, Dichter, Marc A., additional, Rosenfeld, Myrna R., additional, and Lynch, David R., additional
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- 2007
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125. Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis
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Villar, Luisa M., primary, Masjuan, Jaime, additional, González‐Porqué, Pedro, additional, Plaza, José, additional, Sádaba, María C., additional, Roldán, Ernesto, additional, Bootello, Alfredo, additional, and Alvarez‐Cermeño, José C., additional
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- 2002
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126. Neuronal apoptosis induced by cerebrospinal fluid from multiple sclerosis patients correlates with hypointense lesions on T1 magnetic resonance imaging
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Cid, Cristina, primary, Alcázar, Alberto, additional, Regidor, Ignacio, additional, Masjuan, Jaime, additional, Salinas, Matilde, additional, and Álvarez-Cermeño, José C, additional
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- 2002
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127. Acute Ischemic Stroke in a 12-Year-Old Successfully Treated With Mechanical Thrombectomy.
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Maza, Susana Sainz de la, Felipe, Alicia De, Matute, Maria Consuelo, Fandiño, Eduardo, Méndez, José Carlos, Morillo, Pablo, and Masjuan, Jaime
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HEADACHE in children ,CEREBRAL angiography - Abstract
We report the case of a healthy 12-year-old girl with an acute ischemic stroke successfully treated with mechanical thrombectomy. The child was referred to our hospital 6 hours after sudden onset of severe headache and left hemiparesis. Cerebral angiography findings were consistent with right distal internal carotid artery occlusion in addition to ipsilateral middle cerebral artery occlusion. Subsequent mechanical thrombectomy with Solitaire AB device resulted in complete vessel recanalization. The patient experienced progressive neurologic improvement with good clinical recovery at the 3-month follow-up. To our knowledge, only 3 cases of primary mechanical thrombectomy in children have been previously reported in the literature. Safety and efficacy data for endovascular therapies in pediatric acute ischemic stroke are lacking. We propose mechanical thrombectomy as an option in children with significant neurologic deficits and proven arterial occlusion, especially when the therapeutic window for intravenous thrombolysis has been exceeded. [ABSTRACT FROM PUBLISHER]
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- 2014
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128. Induction of apoptosis by cerebrospinal fluid from patients with primary-progressive multiple sclerosis in cultured neurons
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Alcázar, Alberto, primary, Regidor, Ignacio, additional, Masjuan, Jaime, additional, Salinas, Matilde, additional, and Álvarez-Cermeño, José C, additional
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- 1998
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129. Thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack.
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Leciñana, María Alonso, Fuentes, Blanca, Masjuan, Jaime, Simal, Patricia, Díaz-Otero, Fernando, Reig, Gemma, Díez-Tejedor, Exuperio, Gil-Nuñez, Antonio, Vivancos, Jose, and Egido, Jose-Antonio
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THROMBOLYTIC therapy ,STROKE treatment ,TRANSIENT ischemic attack ,CEREBRAL hemorrhage ,REGRESSION analysis - Abstract
Background and aim Safety and efficacy of intravenous thrombolysis in stroke patients with recent transient ischemic attack are hotly debated. Patients suffering transient ischemic attack may present with diffusion-weighted imaging lesions, and although normal computed tomography would not preclude thrombolysis, the concern is that they may be at higher risk for hemorrhage post-thrombolysis treatment. Prior ipsilateral transient ischemic attack might provide protection due to ischemic preconditioning. We assessed post-thrombolysis outcomes in stroke patients who had prior transient ischemic attack. Methods Multicentered prospective study of consecutive acute stroke patients treated with intravenous tissue plasminogen activator ( tPA). Ipsilateral transient ischemic attack, baseline characteristics, risk factors, etiology, and time-lapse to treatment were recorded. National Institutes of Health Stroke Scale at seven-days and modified Rankin Scale at three-months, symptomatic intracranial hemorrhage, and mortality were compared in patients with and without transient ischemic attack. Results There were 877 patients included, 60 (6·84%) had previous ipsilateral transient ischemic attack within one-month prior to the current stroke (65% in the previous 24 h). Transient ischemic attack patients were more frequently men (70% vs. 53%; P = 0·011), younger (63 vs. 71 years of age; P = 0·011), smokers (37% vs. 25%; P = 0·043), and with large vessel disease (40% vs. 25%; P = 0·011). Severity of stroke at onset was similar to those with and without prior transient ischemic attack (median National Institutes of Health Stroke Scale score 12 vs. 14 P = 0·134). Those with previous transient ischemic attack were treated earlier (117 ± 52 vs. 144 ± 38 mins; P < 0·005). After adjustment for confounding variables, regression analysis showed that previous transient ischemic attack was not associated with differences in stroke outcome such as independence (modified Rankin Scale 0-2) (odds ratios: 1·035 (0·57-1·93) P = 0·91), mortality (odds ratios: 0·99 (0·37-2·67) P = 0·99), or symptomatic intracranial hemorrhage (odds ratios: 2·04 (0·45-9·32) P = 0·36). Conclusions Transient ischemic attack preceding ischemic stroke does not appear to have a major influence on outcomes following thrombolysis. Patients with prior ipsilateral transient ischemic attack appear not to be at higher risk of bleeding complications. [ABSTRACT FROM AUTHOR]
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- 2012
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130. Progression independent of relapse activity can be predicted by passively acquired tapping speed through a smartphone for 1 month: A prospective study.
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Chico-Garcia, Juan Luis, Sainz Amo, Raquel, Monreal, Enric, Sainz de la Maza, Susana, Rodriguez Jorge, Fernando, Masjuan, Jaime, Costa-Frossard, Lucienne, and Villar, Luisa María
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MOBILE apps , *REGRESSION analysis , *LOGISTIC regression analysis , *MULTIPLE sclerosis , *LONGITUDINAL method - Abstract
Background: Tapping speed (TS) correlates with baseline disability scales in people with multiple sclerosis (pwMS) Objective: The study aimed to address if progression independent of relapse activity (PIRA) could be predicted by first-month measurement of TS. Methods: Prospective study including pwMS in one referral MS center. Consecutive patients were included and keys/second (Keys/s) were passively measured each day using an in-house smartphone application for 1 month. Median, mean, and maximum keys/s were obtained. Multivariate logistic regression models (including keys/s, age, sex, and baseline disability scores) were obtained for prediction of a PIRA event after 1 year. Results: Overall, 59 patients were included in the final analysis (64.4% women, median age of 44.5 years). However, 10 patients presented a PIRA event, without differences regarding baseline characteristics between PIRA and no-PIRA groups. PIRA group presented lower median keys/s (2 vs 4 keys/s, p = 0.002) and mean keys/s (2.8 vs 4.6, p = 0.008), while maximum keys/s were similar (p = 0.32). A median ⩽ 3 keys/s was independently associated with PIRA (aOR = 16.8, p = 0.03), as did a mean ⩽ 3.7 keys/s (aOR = 17, p = 0.02). These differences were not detected regarding other variables analyzed. Conclusion: Low median or mean keys/s obtained during initial month of assessment were indicative of a PIRA event within the next year. [ABSTRACT FROM AUTHOR]
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- 2024
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131. Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations
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Ruz-Caracuel, Ignacio, Pian-Arias, Héctor, Corral, Íñigo, Carretero-Barrio, Irene, Bueno-Sacristán, Diego, Pérez-Mies, Belén, García-Cosío, Mónica, Caniego-Casas, Tamara, Pizarro, David, García-Narros, María Isabel, Piris-Villaespesa, Miguel, Pestaña, David, de Pablo, Raúl, Galán, Juan Carlos, Masjuan, Jaime, and Palacios, José
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Severe cases of Coronavirus Disease 2019 (COVID-19) can present with multiple neurological symptoms. The available neuropathological studies have described different lesions; the most frequent was the presence of neuroinflammation and vascular-related lesions. The objective of this study was to report the neuropathological studies performed in a medical institution, with abundant long intensive care unit stays, and their associated clinical manifestations. This is a retrospective monocentric case series study based on the neuropathological reports of 13 autopsies with a wide range of illness duration (13–108 days). A neuroinflammatory score was calculated based on the quantification of CD8- and CD68-positive cells in representative areas of the central nervous system. This score was correlated afterwards with illness duration and parameters related to systemic inflammation. Widespread microglial and cytotoxic T-cell activation was found in all patients. There was no correlation between the neuroinflammatory score and the duration of the illness; nor with parameters of systemic inflammation such as the peak of IL-6 or the HScore (a parameter of systemic macrophage activation syndrome). Two patients had global hypoxic ischaemic damage and five patients had subacute infarcts. One patient had many more brain vascular microthrombi compared to the others and multiple subacute pituitary infarcts. SARS-CoV-2 RNA was not detected with qRT-PCR. The proportion of brain lesions in severe COVID-19 patients could be related to illness duration. In our series, with abundant long hospitalisation stays, neuroinflammation was present in all patients and was more prominent between day 34 and day 45 after onset of symptoms. Clinical correlation showed that two patients with the highest neuroinflammatory scores had severe encephalopathies that were not attributable to any other cause. The second most frequent lesions were related to vascular pathology.
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- 2022
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132. Opsoclonus–myoclonus syndrome and limbic encephalitis associated with GABAB receptor antibodies in CSF.
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DeFelipe-Mimbrera, Alicia, Masjuan, Jaime, Corral, Íñigo, Villar, Luisa Maria, Graus, Francesc, and García-Barragán, Nuria
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OPSOCLONUS-Myoclonus syndrome , *LIMBIC system , *ENCEPHALITIS , *GABA agents , *IMMUNOGLOBULINS , *AUTOIMMUNE diseases - Abstract
Abstract: We report a case of a woman who had two consecutive autoimmune neurological disorders, including an opsoclonus–myoclonus syndrome (OMS) and limbic encephalitis (LE), with positive titers of GABAB receptor antibodies. The patient never developed seizures or had an underlying tumor after 4years of follow-up. [Copyright &y& Elsevier]
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- 2014
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133. Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis
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Villar, Luisa M., Masjuan, Jaime, González-Porqué, Pedro, Plaza, José, Sádaba, María C., Roldán, Ernesto, Bootello, Alfredo, and Alvarez-Cermeño, José C.
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Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple sclerosis (MS). The aim of this study was the follow-up of a group of relapsing-remitting MS patients for a longer time to evaluate whether the ITMS implies a poor prognosis. Oligoclonal IgM bands were performed in 29 MS patients followed up from 5 to 16 years. Time to conversion to secondary-progressive MS (SPMS), time elapsed to reach a disability of 6 in the Expanded Disability Status Scale (EDSS), percentage of patients with a benign MS, and changes in EDSS score were evaluated. During the follow-up, 70.8% of patients with ITMS converted to SPMS. None of the patients without ITMS did. At the end of the study, 63.6% of patients with ITMS had reached EDSS 6, whereas none of the patients lacking ITMS reached values above EDSS 3. When patients with benign MS were analyzed, 82% lacked ITMS. All patients with a nonbenign MS had ITMS. At the end of the study, the mean EDSS score was 4.64 in patients with ITMS and 1.31 in those without. The presence of oligoclonal IgM bands in cerebrospinal fluid is an unfavorable prognostic marker in MS. Ann Neurol 2003;53:000000
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- 2003
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134. Malignant Left Atrial Appendage Morphology: Current Classification vs H-L System.
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Parra-Díaz, Paloma, Salido-Tahoces, Luisa, Pardo-Sanz, Ana, Beltrán-Corbellini, Álvaro, Rodríguez-Jorge, Fernando, Chico-García, Juan Luis, García-Madrona, Sebastián, Matute-Lozano, Consuelo, Vera-Lechuga, Rocío, Cruz-Culebras, Antonio, Masjuan, Jaime, and DeFelipe-Mimbrera, Alicia
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Introduction: In previous studies the risk of stroke recurrence has been associated with the left atrial appendage (LAA) morphology (non-chicken wing (NCW)), knowing those with a greater risk as malignant LAA. Recently, a simpler morphological classification has been suggested with two categories: Low-risk (LAA-L) and High-risk (LAA-H); which could be easier to apply and may correlate better with the risk of embolic stroke.Methods: Retrospective analysis from a registry of patients with recurrent cardioembolic strokes despite appropriate anticoagulant therapy, in which LAA morphology was studied with cardiac CT scan. LAA morphology was classified according to the four current categories and H-L morphology by the same cardiologist. Other variables associated with a high risk of stroke were also assessed, such as CHA2DS2-VASc score and left atrial (LA) size.Results: Twenty-six cases were included in the analysis. We identified 22 (84.6%) chicken wing (CW), 1 (3.8%) windsock and 3 (11.5%) cactus by the current classification system, while 15 (57.7%) were classified as LAA-H and 11 (42.3%) as LAA-L by the new system. Half of the 22 cases with CW morphology were considered LAA-H, whereas all NCW were also classified as LAA-H. LA diameter and area were significantly higher in cases with LAA-H morphology (p=0.03 and 0.014), and also in those CW and LAA-H, compared to those CW with LAA-L (p=0.035).Conclusions: With this new classification system more than half of the cases of our malignant LAAs were classified as high-risk morphology. This morphology was also associated with an increased LA size. [ABSTRACT FROM AUTHOR]- Published
- 2021
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135. Establishing Normal Serum Values of Neurofilament Light Chains and Glial Fibrillary Acidic Protein Considering the Effects of Age and Other Demographic Factors in Healthy Adults.
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Rodero-Romero, Alexander, Monreal, Enric, Sainz-Amo, Raquel, García Domínguez, José Manuel, Villarrubia, Noelia, Veiga-González, Jose Luís, Fernández-Velasco, José Ignacio, Goicochea-Briceño, Haydee, Rodríguez-Jorge, Fernando, Sainz de la Maza, Susana, Chico-García, Juan Luís, Muriel, Alfonso, Masjuan, Jaime, Costa-Frossard, Lucienne, and Villar, Luisa María
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GLIAL fibrillary acidic protein , *OLDER people , *CYTOPLASMIC filaments , *SERUM , *DEMOGRAPHIC characteristics , *BODY mass index , *DYSTROPHY - Abstract
Multiple studies have shown the importance of blood-based biomarkers indicating axonal damage (serum neurofilament light chains [sNfL]) or astroglia activation (serum glial fibrillary acidic protein [sGFAP]) for monitoring different neurological diseases. However, normal values of these variables remain to be clearly defined, partly due to the influence of different demographic factors. We investigated demographic differences in a cohort of healthy volunteers. A cross-sectional study was conducted including 116 healthy controls with ages between 18 and 69 years (67.5% females; n = 79). sNfL and sGFAP concentrations were measured using single-molecule arrays. Age and body mass index affected sNfL values, and age was found to be the most important factor. The normal values changed with age, and we established normal values for individuals younger than 45 years as <10 pg/mL and for controls older than 45 years as <15 pg/mL. We established normal values at <10 pg/mL for individuals younger than 45 years and <15 pg/mL for older individuals. Alternatively, a Z-score of 1.5 was relevant for all controls. sGFAP was only affected by age. Differences in normal values were evident by 55 years. The highest normality limit for sGFAP was 140 pg/mL for controls under 55 years and 280 for older controls. We defined normal levels for sNfL and sGFAP and their corresponding age-associated changes. These data may contribute to the application of such variables in clinical practice. [ABSTRACT FROM AUTHOR]
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- 2024
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136. Prediction Of Very Early Stroke Or High-risk Stroke Mechanism In Patients With Transient Ischemic Attack From The Promapa Study. A Prospective Comparison Of Prognostic Risk Scores
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Purroy, Francisco, Jimenez-Caballero, Enrique, Gorospe, Arantza, Torres, J. M., Alvarez-Sabin, Jose, Santamarina, Estevo, Martinez-Sanchez, Patricia, Diez-Tejedor, Exuperio, Canovas, David, Freijo, Mar, Egido, Jose, José María Ramirez-Moreno, Vera, Rocio, Rodriguez, Ana, Roquer, Jaume, Casado, I., Delgado, Raquel, Marti, Joan, Silva, Yolanda, Cardona, Pere, Rubio, Francisco, Morales, Ana, La Ossa, Natalia, Garcia-Pastor, Andres, Arenillas, Juan, Segura, Tomas, Pons, J. M., Jimenez, Carmen, and Masjuan, Jaime
137. Genotyping Recurrence Of Stroke (GRECOS) Project: Two Genes Involved in Hypoxia Responses and Blood Brain Barrier Function Are Associated With Vascular Recurrence in a Preliminary Study
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Mendioroz, Maite, Fernandez-Cadenas, Israel, Adrià Arboix, Palomeras, Ernest, Freijoo, Marimar, Ribo, Marc, Salat, David, Canovas, David, Grau, Marta, Krupinski, Jurek, Angels Font, Maria, Rubio, Francisco, Arenillas, Juan, Davalos, Antonio, Martinez-Zabaleta, Maite, Masjuan, Jaime, Pinana, Carlos, Moniche, Pachi, Serena, Joaquin, Purroy, Francisco, Marti, Joan, Roquer, Jaume, Tejero, Carlos, Aymerich, Nuria, Fernandez-Morales, Jessica, Giralt, Dolors, Del-Rio, Alberto, Alvarez-Sabin, Jose, Montaner, Joan, and Domingues-Montanari, Sophie
138. One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke
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Amarenco, Pierre, Lavallée, Philippa C, Labreuche, Julien, Albers, Gregory W, Bornstein, Natan M, Canhão, Patrícia, Caplan, Louis R, Donnan, Geoffrey A, Ferro, José M, Hennerici, Michael G, Molina, Carlos, Rothwell, Peter M, Sissani, Leila, Skoloudík, David, Steg, Philippe Gabriel, Touboul, Pierre-Jean, Uchiyama, Shinichiro, Vicaut, Éric, Wong, Lawrence K S, Ameriso, Sebastian, Gandolfo, Claudia Nora, Povedano, Guillermo, Saggesse, Javier, Gandolfo, Claudia, Pavon, Heman, Cancino, Jorge, Toledo, Walter, Huang, Yinin, Gong, Xiping, Ma, Yetao, Mi, Donghu, Song, Tian, Wang, Yilong, Wang, Yongjun, Chandgfend, Fran, Congtao, Guo, Hongyun, Jiao, Intao, He, Jixing, Wu, Linlin, Liu, Liquing, Song, Liwen, Tai, Ran, Liu, Shujuan, Tian, Wenhong, Liu, Tsoi, Tak Hong, Wong, Lawrence, Liu, Roxanna, Flasar, Roman, Zítková, Bed?i?ka, Reif, Michal, Goldemund, David, Neumann, Ji?í, Svá?ková, Dagmar, a?ák, Daniel, Král, Michal, koloudík, David, Václavík, Daniel, Kuliha, Martin, Cabrejo, Lucie, Guidoux, Céline, Hobeanu, Cristina Maria, Lavallée, Philippa, Meseguer, Elena, Audebert, Henrich, Menger, Daniel, Heide, Wolfgang, Lipp, Saskia, Ozalp, Huriye, Sctzmann, Christine, Weimar, Christian, Platzbecker, Katharina, Ringleb, Peter, Hennerici, Michel G, Griebe, Martin, Willmann, Katrin Knoll Olaf, Faiss, Juergen harmut, Dillan, Susan, Kobersteein, Anja, Krimmer, Katharina, Tietz, Sandra, Wienecke, Peter, Hamann, Gerhard, Burkhardt, Nico, Liebetrau, Martin, Mueller, Nadine, Wagner, Michaela, Strivastava, Kelly, Peter, Merwick, Aline, Tanne, David, Cavazzuti, Milena, Anticoli, Sabrina, Toni, Danilo, Nagata, Ken, Okada, Yasushi, Yamagami, Hiroshi, Minematsu, Kazuo, Nakagawara, Jojo, Lee, Byung Chui, Yoon, Byung Woo, Hoe, Ji Hoe, Park, Jong Moo, Abboud, Halim, Koussa, Salam, Awada, Adnan, Tan, Kay Sin, Arauz, Antonio, Gongora, Fernando, Valenzuela, Adrian Infante, Escamilla, Juan M, Canhao, Patrica, Ferro, Jose, Fonseca, Ana Catarina, Correia, Manuel, Tuna, Assuncao, Sternic, Nada, Mijajlovic, Aleksandra Pavlovic Milija, Dupejova, Beata, Szedelyová, Jana, Smirkova, Renata, Segura, Tomas, Rodgriguez, Ana, Silva, Yolanda, Tejada, Javier, Purroy, Francisco, Masjuan, Jaime, Vivancos, Jose, Palomeras, Ernest, Gamemro, Miguel Angel, Arenillas, J F, Calleja, Anna, Rojo, Esther, Buchan, Alastair, Rothwell, Peter, Lee, Tsong Hai, Chang, Ku chou, Huang, Yu-Ching, Lin, Ruey-Tay, Tiamkao, Somsak, and the TIAregistry.org Investigators
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Male ,ABCD(2) SCORE ,Medizin ,Infarction ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,Recurrence ,Risk Factors ,Stroke ,biology ,TIAregistry.org Investigators ,Ischemic Attack ,Transient ,Medicine (all) ,Composite outcomes ,Minor stroke ,General Medicine ,11 Medical And Health Sciences ,Middle Aged ,TIME ,Cardiovascular Diseases ,Ischemic Attack, Transient ,Female ,INFARCTION ,Life Sciences & Biomedicine ,Healthcare system ,Risk ,Acute coronary syndrome ,medicine.medical_specialty ,Aged ,Humans ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,ABCD2 ,medicine ,cardiovascular diseases ,Science & Technology ,business.industry ,TIA ,medicine.disease ,RANDOMIZED-TRIAL ,INDIVIDUALS ,Emergency medicine ,biology.protein ,Physical therapy ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. The TIAregistry.org project was designed to describe the contemporary profile, etiologic factors, and outcomes in patients with a TIA or minor ischemic stroke who receive care in health systems that now offer urgent evaluation by stroke specialists. METHODS We recruited patients who had had a TIA or minor stroke within the previous 7 days. Sites were selected if they had systems dedicated to urgent evaluation of patients with TIA. We estimated the 1-year risk of stroke and of the composite outcome of stroke, an acute coronary syndrome, or death from cardiovascular causes. We also examined the association of the ABCD2 score for the risk of stroke (range, 0 [lowest risk] to 7 [highest risk]), findings on brain imaging, and cause of TIA or minor stroke with the risk of recurrent stroke over a period of 1 year. RESULTS From 2009 through 2011, we enrolled 4789 patients at 61 sites in 21 countries. A total of 78.4% of the patients were evaluated by stroke specialists within 24 hours after symptom onset. A total of 33.4% of the patients had an acute brain infarction, 23.2% had at least one extracranial or intracranial stenosis of 50% or more, and 10.4% had atrial fibrillation. The Kaplan–Meier estimate of the 1-year event rate of the composite cardiovascular outcome was 6.2% (95% confidence interval, 5.5 to 7.0). Kaplan–Meier estimates of the stroke rate at days 2, 7, 30, 90, and 365 were 1.5%, 2.1%, 2.8%, 3.7%, and 5.1%, respectively. In multivariable analyses, multiple infarctions on brain imaging, large-artery atherosclerosis, and an ABCD2 score of 6 or 7 were each associated with more than a doubling of the risk of stroke. CONCLUSIONS We observed a lower risk of cardiovascular events after TIA than previously reported. The ABCD2 score, findings on brain imaging, and status with respect to large-artery atherosclerosis helped stratify the risk of recurrent stroke within 1 year after a TIA or minor stroke. (Funded by Sanofi and Bristol-Myers Squibb.) Supported by an unrestricted grant from Sanofi and Bristol-Myers Squibb.
139. Stroke with polyvascular atherothrombotic disease is associated with increased levels of molecular inflammatory markers and recurrence rates
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Blanco, Miguel, Sobrino, Tomas, Montaner, Joan, Medrano, Vicente, Jimenez, Carmen, Masjuan, Jaime, Gomez, Carlos, Luis, Pilar, Adrià Arboix, and Castillo, Jose
140. Successful intravenous thrombolysis in acute ischaemic stroke in a patient on rivaroxaban treatment.
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Maciej Kawiorski, Michal, Alonso-Canovas, Araceli, de Felipe Mimbrera, Alicia, Sainz de la Maza, Susana, Alvarez-Velasco, Rodrigo, Zarza, Beatriz, and Masjuan, Jaime
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- 2014
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141. Successful intravenous thrombolysis in acute ischaemic stroke in a patient on rivaroxaban treatment
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Kawiorski, Michal Maciej, Alonso-Canovas, Araceli, Mimbrera, Alicia de Felipe, Maza, Susana Sainz de la, Alvarez-Velasco, Rodrigo, Zarza, Beatriz, and Masjuan, Jaime
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- 2014
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142. TREATMENT-RESPONSIVE SUBACUTE LIMBIC ENCEPHALITIS AND NMDA RECEPTOR ANTIBODIES IN A MAN
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Novillo-López, María Elena, Rossi, Jeffrey E., Dalmau, Josep, and Masjuan, Jaime
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- 2008
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143. Abstract T P185.
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Martinez-Sanchez, Patricia, Alonso De Leciñana, María, Miralles-Martínez, Ambrosio, Huertas-Gonzalez, Nuria, Martín-Martínez, Alfonso, Correas-Callero, Elisa, Sanz De Barros, Rosa, Domingo-García, Julio, Serrano-López, Soledad, Fuentes, Blanca, Masjuan, Jaime, Ruiz-Ares, Gerardo, Martinez-Martinez, Marta, Sanz-Cuesta, Borja E, Cruz-Herranz, Andrés, and Díez-Tejedor, Exuperio
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- 2014
144. Abstract T P19.
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Fuentes, Blanca, Alonso De Leciñana, Maria, Ximenez-Carrillo, Alvaro, Martínez-Sánchez, Patricia, Cruz-Culebras, Antonio, Zapata, Gustavo, Ruiz-Ares, Gerardo, Masjuan, Jaime, Vivancos, Jose, and Diez-Tejedor, Exuperio
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- 2014
145. Abstract 2669.
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Fuentes, Blanca, MartÍnez-Sánchez, Patricia, Alonso De Leciñana, MarÍa, Egido, Jose, Reig, Gemma, DÍaz-Otero, Fernando, Sanchez, Victor, Simal, Patricia, Ximenez-Carrillo, Alvaro, GarcÍa-Pastor, Andrés, Ruiz-Ares, Gerardo, GarcÍa-GarcÍa, Ana, Masjuan, Jaime, Vivancos-Mora, Jose, Gil-Nuñez, Antonio C, and DÍez-Tejedor, Exuperio
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- 2012
146. Progressive Multifocal Leukoencephalopathy, Natalizumab, and Multiple Sclerosis.
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Ãlvarez-Cermeño, José C., Masjuan, Jaime, and Villar, Luisa M.
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LETTERS to the editor , *MULTIPLE sclerosis treatment - Abstract
A letter to the editor is presented in response to the article "Progressive Multifocal Leukoencephalopathy Complicating Treatment With Natalizumab and Interferon Beta-1a for Multiple Sclerosis," by B.K. Kleinschmidt-DeMasters and K.L. Tyler in the July 28, 2005 issue.
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- 2005
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147. Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial.
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Shoamanesh, Ashkan, Mundl, Hardi, Smith, Eric E, Masjuan, Jaime, Milanov, Ivan, Hirano, Teruyuki, Agafina, Alina, Campbell, Bruce, Caso, Valeria, Mas, Jean-Louis, Dong, Qiang, Turcani, Peter, Christensen, Hanne, Ferro, Jose M, Veltkamp, Roland, Mikulik, Robert, De Marchis, Gian Marco, Robinson, Thompson, Lemmens, Robin, and Stepien, Adam
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Background: Asundexian (Bayer AG, Leverkusen, Germany), an oral small molecule factor XIa (FXIa) inhibitor, might prevent thrombosis without increasing bleeding. Asundexian's effect for secondary prevention of recurrent stroke is unknown.Methods: In this randomised, double-blind, placebo-controlled, phase 2b dose-finding trial (PACIFIC-Stroke), patients with acute (within 48 h) non-cardioembolic ischaemic stroke were recruited from 196 hospitals in 23 countries. Patients were eligible if they were aged 45 years or older, to be treated with antiplatelet therapy, and able to have a baseline MRI (either before or within 72 h of randomisation). Eligible participants were randomly assigned (1:1:1:1), using an interactive web-based response system and stratified according to anticipated antiplatelet therapy (single vs dual), to once daily oral asundexian (BAY 2433334) 10 mg, 20 mg, or 50 mg, or placebo in addition to usual antiplatelet therapy, and were followed up during treatment for 26-52 weeks. Brain MRIs were obtained at study entry and at 26 weeks or as soon as possible after treatment discontinuation. The primary efficacy outcome was the dose-response effect on the composite of incident MRI-detected covert brain infarcts and recurrent symptomatic ischaemic stroke at or before 26 weeks after randomisation. The primary safety outcome was major or clinically relevant non-major bleeding as defined by International Society on Thrombosis and Haemostasis criteria. The efficacy outcome was assessed in all participants assigned to treatment, and the safety outcome was assessed in all participants who received at least one dose of study treatment. This study is registered with ClinicalTrials.gov, NCT04304508, and is now complete.Findings: Between June 15, 2020, and July 22, 2021, 1880 patients were screened and 1808 participants were randomly assigned to asundexian 10 mg (n=455), 20 mg (n=450), or 50 mg (n=447), or placebo (n=456). Mean age was 67 years (SD 10) and 615 (34%) participants were women, 1193 (66%) were men, 1505 (83%) were White, and 268 (15%) were Asian. The mean time from index stroke to randomisation was 36 h (SD 10) and median baseline National Institutes of Health Stroke Scale score was 2·0 (IQR 1·0-4·0). 783 (43%) participants received dual antiplatelet treatment for a mean duration of 70·1 days (SD 113·4) after randomisation. At 26 weeks, the primary efficacy outcome was observed in 87 (19%) of 456 participants in the placebo group versus 86 (19%) of 455 in the asundexian 10 mg group (crude incidence ratio 0·99 [90% CI 0·79-1·24]), 99 (22%) of 450 in the asundexian 20 mg group (1·15 [0·93-1·43]), and 90 (20%) of 447 in the asundexian 50 mg group (1·06 [0·85-1·32]; t statistic -0·68; p=0·80). The primary safety outcome was observed in 11 (2%) of 452 participants in the placebo group versus 19 (4%) of 445 in the asundexian 10 mg group, 14 (3%) of 446 in the asundexian 20 mg group, and 19 (4%) of 443 in the asundexian 50 mg group (all asundexian doses pooled vs placebo hazard ratio 1·57 [90% CI 0·91-2·71]).Interpretation: In this phase 2b trial, FXIa inhibition with asundexian did not reduce the composite of covert brain infarction or ischaemic stroke and did not increase the composite of major or clinically relevant non-major bleeding compared with placebo in patients with acute, non-cardioembolic ischaemic stroke.Funding: Bayer AG. [ABSTRACT FROM AUTHOR]- Published
- 2022
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148. SAFETY OF THROMBOLYSIS WITH IV RT-PA IN PATIENTS WITH ATRIAL FIBRILLATION RELATED ISCHEMIC STROKES AND PRIOR SUBTHERAPEUTIC USE OF COUMARINIC ANTICOAGULANTS.
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Terecoasa, Elena, Tiu, Cristina, Masjuan, Jaime, de Lecinana, Maria Alonso, and Gheorghe A. Dan
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THROMBOLYTIC therapy , *STROKE , *ATRIAL fibrillation , *ANTICOAGULANTS , *INTRACEREBRAL hematoma , *NEUROLOGY - Abstract
Background and purpose. There are conflicting data in the literature regarding the safety of intravenous thrombolysis in patients with ischemic strokes receiving prior treatment with vitamin K antagonists. We aimed to assess the safety, short term outcome and mortality after rt-PA administration in patients with atrial fibrillation related strokes and prior subtherapeutic use of vitamin K antagonists. Methods. The study included 210 patients with atrial fibrillation who received treatment with intravenous rt-PA for acute ischemic stroke. We compared the frequency of bleeding complications, including intracerebral hemorrhage of any type and symptomatic intracerebral hemorrhage in patients with and without preadmission acenocoumarol use. We also investigated whether there were differences regarding short term functional outcome (assessed with the modified Rankin score at three months after thrombolysis) and mortality rates between them. Results. 48 patients (22.8%) were receiving acenocoumarol before admission and had international normal ratio (INR) = 1.7. In this group, the median INR value was 1.4 (IQR 1.3-1.6). Preadmission coumarinic anticoagulants use was neither associated with secondary intracerebral hemorrhage of any type (p = 0.9), nor with symptomatic intracerebral hemorrhage (p = 0.9). Moreover, no differences regarding short term stroke outcome (p = 0.86), and mortality (p = 0.56) were observed between patients with or without prior acenocoumarol use. Using logistic regression analysis NIHSS score was found to be the only independent predictor for both short term stroke outcome (OR = 0.82; 95% CI 0.77-0.87; p < 0.0001) and mortality (OR = 1.18; 95%CI 1.09-1.27; p < 0.0001). Chronic heart failure was a second independent predictor for mortality (OR = 3.66; 95%CI 1.41-9.5; p = 0.007). Blood pressure values of more than 185/110 mmHg during the first 24 hours after stroke onset were independently associated with the short term stroke outcome (OR 0.37; 95% CI 0.15-1.88; p = 0.02). Conclusion. In the present study the rates of intracranial hemorrhage and mortality following intravenous thrombolysis for atrial fibrillation related ischemic strokes were not different between the patients who were prior receiving subtherapeutic treatment with acenocoumarol and those who were not receiving coumarinic oral anticoagulants at all. As a result, the use of recombinant tissue plasminogen activator in this clinical setting seems to be safe. Further studies with larger number of patients and a prospective design are needed to confirm these findings. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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149. A first update on mapping the human genetic architecture of COVID-19
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COVID-19 Host Genetics Initiative, Pathak, GA, Karjalainen, J, Stevens, C, Neale, BM, Daly, M, Ganna, A, Andrews, SJ, Kanai, M, Cordioli, M, Polimanti, R, Harerimana, N, Pirinen, M, Liao, RG, Chwialkowska, K, Trankiem, A, Balaconis, MK, Nguyen, H, Solomonson, M, Veerapen, K, Wolford, B, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Niemi, MEK, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Azarzar, S, Gofflot, S, Claassen, S, Malaise, O, Huynen, P, Meuris, C, Thys, M, Jacques, J, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Frenckell, CV, Belhaj, Y, Lambermont, B, Nakanishi, T, Morrison, DR, Mooser, V, Richards, JB, Butler-Laporte, G, Forgetta, V, Li, R, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, 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Giuseppe, Castori, Marco, Aucella, Filippo, Biagio, Antonio Di, Masucci, Luca, Valente, Serafina, Mandalà, Marco, Zucchi, Patrizia, Giannattasio, Ferdinando, Coviello, Domenico A., Mussini, Cristina, Tavecchia, Luisa, Crotti, Lia, Rizzi, Marco, Rovere, Maria Teresa La, Sarzi-Braga, Simona, Bussotti, Maurizio, Ravaglia, Sabrina, Artuso, Rosangela, Perrella, Antonio, Romani, Davide, Bergomi, Paola, Catena, Emanuele, Vincenti, Antonella, Ferri, Claudio, Grassi, Davide, Pessina, Gloria, Tumbarello, Mario, Pietro, Massimo Di, Sabrina, Ravaglia, Luchi, Sauro, Furini, Simone, Dei, Simona, Benetti, Elisa, Picchiotti, Nicola, Sanarico, Maurizio, Ceri, Stefano, Pinoli, Pietro, Raimondi, Francesco, Biscarini, Filippo, Stella, Alessandra, Zguro, Kristina, Capitani, Katia, Tanfoni, Marco, Fallerini, Chiara, Daga, Sergio, Baldassarri, Margherita, Fava, Francesca, Frullanti, Elisa, Valentino, Floriana, Doddato, Gabriella, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Rizzo, Caterina Lo, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Sarno, Laura Di, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Mantovani, Stefania, Ludovisi, Serena, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Siano, Matteo, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennett, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Guerrini, Susanna, Conticini, Edoardo, Frediani, Bruno, Spertilli, Chiara, Donati, Alice, Guidelli, Luca, Corridi, Marta, Croci, Leonardo, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Verzuri, Agnese, Anemoli, Valentina, Pancrazzi, Alessandro, Lorubbio, Maria, Miraglia, Federica Gaia, Venturelli, Sophie, Cossarizza, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Paciosi, Francesco, Andretta, Francesca, Gatti, Francesca, Parisi, Saverio Giuseppe, Baratti, Stefano, Piscopo, Carmelo, Russo, Roberta, Andolfo, Immacolata, Iolascon, Achille, Carella, Massimo, Merla, Giuseppe, Squeo, Gabriella Maria, Raggi, Pamela, Marciano, Carmen, Perna, Rita, Bassetti, Matteo, Sanguinetti, Maurizio, Giorli, Alessia, Salerni, Lorenzo, Parravicini, Pierpaolo, Menatti, Elisabetta, Trotta, Tullio, Coiro, Gabriella, Lena, Fabio, Martinelli, Enrico, Mancarella, Sandro, Gabbi, Chiara, Maggiolo, Franco, Ripamonti, Diego, Bachetti, Tiziana, Suardi, Claudia, Parati, Gianfranco, Bottà, Giordano, Domenico, Paolo Di, Rancan, Ilaria, Bianchi, Francesco, Colombo, Riccardo, Barbieri, Chiara, Acquilini, Donatella, Andreucci, Elena, Segala, Francesco Vladimiro, Tiseo, Giusy, Falcone, Marco, Lista, Mirjam, Poscente, Monica, Vivo, Oreste De, Petrocelli, Paola, Guarnaccia, Alessandra, Baroni, Silvia, van Heel, David A., Hunt, Karen A., Trembath, Richard C., Huang, Qin Qin, Martin, Hilary C., Mason, Dan, Trivedi, Bhavi, Wright, John, Finer, Sarah, Akhtar, Shaheen, Anwar, Mohammad, Arciero, Elena, Ashraf, Samina, Breen, Gerome, Chung, Raymond, Curtis, Charles J., Chowdhury, Maharun, Colligan, Grainne, Deloukas, Pano, Durham, Ceri, Griffiths, Chri, Hurles, Matt, Hussain, Shapna, Islam, Kamrul, Khan, Ahsan, Khan, Amara, Lavery, Cath, Lee, Sang Hyuck, Lerner, Robin, MacArthur, Daniel, MacLaughlin, Bev, Martin, Hilary, Miah, Shefa, Newman, Bill, Safa, Nishat, Tahmasebi, Farah, Griffiths, Christopher J., Smith, Albert V., Boughton, Andrew P., Li, Kevin W., LeFaive, Jonathon, Annis, Aubrey, Niavarani, Ahmadreza, Aliannejad, Rasoul, Sharififard, Bahareh, Amirsavadkouhi, Ali, Naderpour, Zeinab, Tadi, Hengameh Ansari, Aleagha, Afshar Etemadi, Ahmadi, Saeideh, Moghaddam, Seyed Behrooz Mohseni, Adamsara, Alireza, Saeedi, Morteza, Abdollahi, Hamed, Hosseini, Abdolmajid, Chariyavilaskul, Pajaree, Jantarabenjakul, Watsamon, Hirankarn, Nattiya, Chamnanphon, Monpat, Suttichet, Thitima B., Shotelersuk, Vorasuk, Pongpanich, Monnat, Phokaew, Chureerat, Chetruengchai, Wanna, Putchareon, Opa, Torvorapanit, Pattama, Puthanakit, Thanyawee, Suchartlikitwong, Pintip, Nilaratanakul, Voraphoj, Sodsai, Pimpayao, Brumpton, Ben M., Hveem, Kristian, Willer, Cristen, Zhou, Wei, Rogne, Tormod, Solligard, Erik, Åsvold, Bjørn Olav, Franke, Lude, Boezen, Marike, Deelen, Patrick, Claringbould, Annique, Lopera, Esteban, Warmerdam, Robert, Vonk, Judith. M., van Blokland, Irene, Lanting, Pauline, Ori, Anil P. S., Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Perez, Emma F., Zöllner, Sebastian, Wang, Jiongming, Beck, Andrew, Sloofman, Laura G., Ascolillo, Steven, Sebra, Robert P., Collins, Brett L., Levy, Te, Buxbaum, Joseph D., Sealfon, Stuart C., Jordan, Daniel M., Thompson, Ryan C., Gettler, Kyle, Chaudhary, Kumardeep, Belbin, Gillian M., Preuss, Michael, Hoggart, Clive, Choi, Sam, Underwood, Slayton J., Salib, Irene, Britvan, Bari, Keller, Katherine, Tang, Lara, Peruggia, Michael, Hiester, Liam L., Niblo, Kristi, Aksentijevich, Alexandra, Labkowsky, Alexander, Karp, Avromie, Zlatopolsky, Menachem, Zyndorf, Marissa, Charney, Alexander W., Beckmann, Noam D., Schadt, Eric E., Abul-Husn, Noura S., Cho, Judy H., Itan, Yuval, Kenny, Eimear E., Loos, Ruth J. F., Nadkarni, Girish N., Do, Ron, O’Reilly, Paul, Huckins, Laura M., Ferreira, Manuel A. R., Abecasis, Goncalo R., Leader, Joseph B., Cantor, Michael N., Justice, Anne E., Carey, Dave J., Chittoor, Geetha, Josyula, Navya Shilpa, Kosmicki, Jack A., Horowitz, Julie E., Baras, Ari, Gass, Matthew C., Yadav, Ashish, Mirshahi, Tooraj, Hottenga, Jouke Jan, Bartels, Meike, de geus, Eco E. J. C., Nivard, Michel M. G., Verma, Anurag, Ritchie, Marylyn D., Rader, Daniel, Li, Binglan, Verma, Shefali S., Lucas, Anastasia, Bradford, Yuki, Abedalthagafi, Malak, Alaamery, Manal, Alshareef, Abdulraheem, Sawaji, Mona, Massadeh, Salam, AlMalik, Abdulaziz, Alqahtani, Saleh, Baraka, Dona, Harthi, Fawz Al, Alsolm, Ebtehal, Safieh, Leen Abu, Alowayn, Albandary M., Alqubaishi, Fatimah, Mutairi, Amal Al, Mangul, Serghei, Almutairi, Mansour, Aljawini, Nora, Albesher, Nour, Arabi, Yaseen M., Mahmoud, Ebrahim S., Khattab, Amin K., Halawani, Roaa T., Alahmadey, Ziab Z., Albakri, Jehad K., Felemban, Walaa A., Suliman, Bandar A., Hasanato, Rana, Al-Awdah, Laila, Alghamdi, Jahad, AlZahrani, Deema, AlJohani, Sameera, Al-Afghani, Hani, AlDhawi, Nouf, AlBardis, Hadeel, Alkwai, Sarah, Alswailm, Moneera, Almalki, Faisal, Albeladi, Maha, Almohammed, Iman, Barhoush, Eman, Albader, Anoud, Alotaibi, Sara, Alghamdi, Bader, Jung, Junghyun, fawzy, Mohammad S., Alrashed, May, Zeberg, Hugo, Nkambul, Lindo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklo, Tardif, Nicola, Rooyackers, Olav, Grip, Jonathan, Maricic, Tomislav, Helgeland, Øyvind, Magnus, Per, Trogstad, Lill-Iren S., Lee, Yunsung, Harris, Jennifer R., Mangino, Massimo, Spector, Tim D., Emma, Duncan, Moutsianas, Louka, Caulfield, Mark J., Scott, Richard H., Kousathanas, Athanasio, Pasko, Dorota, Walker, Susan, Stuckey, Alex, Odhams, Christopher A., Rhodes, Daniel, Fowler, Tom, Rendon, Augusto, Chan, Georgia, Arumugam, Prabhu, Karczewski, Konrad J., Martin, Alicia R., Wilson, Daniel J., Spencer, Chris C. A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikola, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Seed, Cotton, Daly, Mark J., Finucane, Hilary, Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicola, Koelling, Nil, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Soranzo, Nicole, Zhao, Jing Hua, Danesh, John, Angelantonio, Emanuele Di, Butterworth, Adam S., Sun, Yan V., Huffman, Jennifer E., Cho, Kelly, O’Donnell, Christopher J., Tsao, Phil, Gaziano, J. Michael, Peloso, Gina, Ho, Yuk-Lam, Smieszek, Sandra P., Polymeropoulos, Christo, Polymeropoulos, Vasilio, Polymeropoulos, Mihael H., Przychodzen, Bartlomiej P., Fernandez-Cadenas, Israel, Planas, Anna M., Perez-Tur, Jordi, Llucià-Carol, Laia, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, DeDiego, Marta L., Iglesias, Lara Lloret, Soriano, Alex, Rico, Veronica, Agüero, Daiana, Bedini, Josep L., Lozano, Francisco, Domingo, Carlo, Robles, Veronica, Ruiz-Jaén, Francisca, Márquez, Leonardo, Gomez, Juan, Coto, Eliecer, Albaiceta, Guillermo M., García-Clemente, Marta, Dalmau, David, Arranz, Maria J., Dietl, Beatriz, Serra-Llovich, Alex, Soler, Pere, Colobrán, Roger, Martín-Nalda, Andrea, Martínez, Alba Parra, Bernardo, David, Rojo, Silvia, Fiz-López, Aida, Arribas, Elisa, de la Cal-Sabater, Paloma, Segura, Tomá, González-Villa, Esther, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Jiménez-Xarrié, Elena, de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastian, Domínguez-Mayoral, Anna, Villalonga, Joan Montaner, Menéndez-Valladares, Paloma, Chasman, Daniel I., Sesso, Howard D., Manson, JoAnn E., Buring, Julie E., Ridker, Paul M., Franco, Giulianini, Davis, Lea, Lee, Sulggi, Priest, Jame, Sankaran, Vijay G., van Heel, David, Biesecker, Le, Kerchberger, V. Eric, Baillie, J. Kenneth, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Biological Psychology, APH - Mental Health, AMS - Sports, AMS - Ageing & Vitality, APH - Methodology, Mccurdy, Shannon, Mccormick, Joseph B., Macarthur, Daniel, Maclaughlin, Bev, Lefaive, Jonathon, Almalik, Abdulaziz, Alzahrani, Deema, Aljohani, Sameera, Aldhawi, Nouf, Albardis, Hadeel, Fawzy, Mohammad S., Dediego, Marta L., Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), University of Zurich, COVID-19 Host Genetics Initiative, Barcelona Supercomputing Center, COVID-19 Genetics Initiative, including authors, Institute for Molecular Medicine Finland, and Data Science Genetic Epidemiology Lab
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Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC] ,Quantitative Trait Loci ,MUC5B PROMOTER POLYMORPHISM ,Genome-wide association studies ,COVID-19 (Malaltia) ,UFSP13-7 Evolution in Action: From Genomes to Ecosystems ,COVID-19 (Disease) ,Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA ,SDG 3 - Good Health and Well-being ,Humans ,genetics ,Genetic variation ,Genomes ,Medicinsk genetik ,1000 Multidisciplinary ,Multidisciplinary ,Chromosome Mapping ,COVID-19 ,Human Genetics ,10124 Institute of Molecular Life Sciences ,covid-19 ,3121 General medicine, internal medicine and other clinical medicine ,570 Life sciences ,biology ,Medical Genetics - Abstract
Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals); (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals); and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1. We found a total of 23 genome-wide significant loci (P
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- 2022
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150. Transcranial sonography in atypical parkinsonism: How reliable is it in real clinical practice? A multicentre comprehensive study.
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Alonso-Canovas, Araceli, Tembl Ferrairó, José Ignacio, Martínez-Torres, Irene, Lopez-Sendon Moreno, Jose Luis, Parees-Moreno, Isabel, Monreal-Laguillo, Enric, Pérez-Torre, Paula, Toledano Delgado, Rafael, García Ribas, Guillermo, Sastre Bataller, Isabel, Masjuan, Jaime, Martinez-Castrillo, Juan Carlos, and Walter, Uwe
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PROGRESSIVE supranuclear palsy , *MULTIPLE system atrophy , *PARKINSONIAN disorders , *PARKINSON'S disease , *ULTRASONIC imaging , *SUBSTANTIA nigra - Abstract
Introduction: Substantia nigra hyperechogenicity (SN+) in transcranial sonography (TCS) is frequent in Parkinson's disease (PD), while lenticular nucleus hyperechogenicity (LN+) and 3rd ventricle enlargement (3V+) are typical of Atypical Parkinsonisms (AP). However, there are no studies assessing the diagnostic yield of all TCS biomarkers in the three AP (progressive supranuclear palsy, PSP, multiple system atrophy, MSA, corticobasal degeneration, CBD). Previous references lack homogeneous criteria and data are incomprehensive.Methods: Analysis of TCS performed in routine clinical practice in AP and PD patients from two tertiary hospitals. Expert recommendations were strictly followed. Previous literature was critically analysed.Results: 155 AP (98 PSP, 40 MSA, 14 CBD), 254 PD, 145 control subjects were included. We confirmed good sensitivity for SN+ in PD (80%), but specificity was lower than reported (61%). LN+ and 3V + had moderate sensitivity for AP and PSP diagnosis respectively (65%, 63%), but specificity was higher than reported (87%, 91%). We confirmed high specificity and positive predictive value of the combination SN/LN (98%, 93% AP; 83%, 86% PD). The combinations of two or three echofeatures, previously unreported, showed high specificity but lower sensitivity (SN/3V: 75% sensitivity, 87% specificity PD; 42% sensitivity, 98% specificity PSP) (SN + LN+: 79% sensitivity, 86% specificity CBD) (SN/3V/LN: 67% sensitivity, 89% specificity PD; 29% sensitivity, 99% specificity PSP; 41% sensitivity, 95% specificity MSA; 57% sensitivity 91% specificity CBD).Conclusions: We present a large comprehensive study of TCS, confirming its usefulness and certain limitations in AP diagnosis. Adherence to consensus criteria is critical to implement TCS for clinical and research purposes. [ABSTRACT FROM AUTHOR]- Published
- 2019
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