101. Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study
- Author
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Shigeyuki Nishimura, Satoko Nakamura, Tsuguru Hatta, Tsunehiko Nishimura, Nobuhiko Joki, Tokuo Kasai, Yasuchika Takeishi, Mitsuru Momose, Hiroki Hase, Naoya Matsumoto, Hideo Kusuoka, Masao Moroi, Kazuya Takehana, Yuhei Kawano, Mamoru Nanasato, Kenichi Nakajima, Susumu Nakagawa, S. Yoda, and Hidetaka Nishina more...
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Gated SPECT ,Myocardial Infarction ,Renal function ,Contrast Media ,030204 cardiovascular system & hematology ,Disease-Free Survival ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,Myocardial perfusion imaging ,Electrocardiography ,0302 clinical medicine ,Japan ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,Survival rate ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Myocardial Perfusion Imaging ,Middle Aged ,medicine.disease ,Prognosis ,Treatment Outcome ,Heart failure ,Multivariate Analysis ,Cardiology ,Kidney Failure, Chronic ,Female ,Cardiology and Cardiovascular Medicine ,business ,Software ,Kidney disease ,Glomerular Filtration Rate - Abstract
Myocardial perfusion imaging (MPI) is considered useful for risk stratification among patients with chronic kidney disease (CKD), without renal deterioration by contrast media. The Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS 3) is a multicenter, prospective cohort study investigating the ability of MPI to predict cardiac events in 529 CKD patients without a definitive coronary artery disease. All patients were assessed by stress and rest MPI with 99mTc-tetrofosmin and data were analyzed using a defect scoring method and QGS software. Major cardiac events were analyzed for 3 years after registration. The mean eGFR was 29.0 ± 12.8 (mL/minute/1.73 m2). The mean summed stress/rest/difference (SSS, SRS, SDS) scores were 1.9 ± 3.8, 1.1 ± 3.0, and 0.8 ± 1.8, respectively. A total of 60 cardiac events (three cardiac deaths, six sudden deaths, five nonfatal myocardial infarctions, 46 hospitalization cases for heart failure) occurred. The event-free survival rate was lower among patients with kidney dysfunction, higher SSS, and higher CRP values. Multivariate Cox regression analysis independently associated SSS ≥8, eGFR more...
- Published
- 2016