101. Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study
- Author
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Yu Chen, Rabiul Hasan, Joseph H. Graziano, Faruque Parvez, Alauddin Ahmed, Mengling Liu, Vesna Slavkovich, Gene R. Pesola, Mary V Gamble, Habibul Ahsan, and Tariqul Islam
- Subjects
Male ,medicine.medical_specialty ,Urinalysis ,Epidemiology ,Urinary system ,India ,Comorbidity ,urologic and male genital diseases ,Other Original Articles ,Gastroenterology ,Severity of Illness Index ,Arsenic ,Cohort Studies ,Age Distribution ,Internal medicine ,Arsenic Poisoning ,medicine ,Confidence Intervals ,Odds Ratio ,Humans ,Longitudinal Studies ,Sex Distribution ,Developing Countries ,Proteinuria ,medicine.diagnostic_test ,business.industry ,urogenital system ,Incidence (epidemiology) ,Drinking Water ,Incidence ,Hazard ratio ,General Medicine ,Odds ratio ,Survival Analysis ,Confidence interval ,female genital diseases and pregnancy complications ,Surgery ,Female ,medicine.symptom ,business ,Cohort study - Abstract
Proteinuria has been recognized as a marker for an increased risk of chronic renal disease. It is unclear whether arsenic (As) exposure from drinking water is associated with proteinuria.We evaluated the association between As exposure from drinking water and proteinuria in 11,122 participants in the Health Effects of Arsenic Longitudinal Study (HEALS). Proteinuria was detected by urinary dipstick tests at baseline and at 2-year intervals. As exposure variables included baseline well As and changes in urinary As during follow-up modelled as time-dependent variables in the analyses.At baseline, well As was positively related to prevalence of proteinuria; prevalence odds ratios (PORs) for proteinuria in increasing quintiles of well As (≤ 7, 8-39, 40-91, 92-179 and 180-864 µg/l) were 1.00 (ref), POR 0.99 [95% confidence interval (CI) 0.77-1.27], POR 1.23 (95% CI 0.97-1.57), POR 1.50 (95% CI 1.18-1.89) and POR 1.59 (95% CI 1.26-2.00) (P for trend0.01). Hazard ratios for incidence of proteinuria were POR 0.83 (95% CI 0.67-1.03) and POR 0.91 (95% CI 0.74-1.12) for participants with a decreasing level of70 and 17-70 µg/l in urinary As over time, respectively, and were POR 1.17 (95% CI 0.97-1.42) and POR 1.42 (95% CI 1.16-1.73) for participants with an increasing level of 16-68 and68 µg/l in urinary As over time, respectively, compared with the group with relatively little changes in urinary As as the reference group (urinary As -16 to 15 µg/l).The findings suggest that there are adverse effects of As exposure on the risk of proteinuria and the effects are modifiable by recent changes in As exposure.
- Published
- 2011