1,888 results on '"Maroli AS"'
Search Results
102. Rectal Cancer in Adolescent and Young Adult Patients: Pattern of Clinical Presentation and Case-Matched Comparison of Outcomes
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Foppa, Caterina, Francesca Bertuzzi, Alexia, Cianchi, Fabio, Carvello, Michele, Maroli, Annalisa, Wolthuis, Albert M., Rimassa, Lorenza, Laghi, Luigi, Montorsi, Marco, D’Hoore, André J.L., and Spinelli, Antonino
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- 2021
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103. Molecular Mechanism of T-2 Toxin-Induced Cerebral Edema by Aquaporin-4 Blocking and Permeation.
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Nikhil Maroli, Naveen Kumar Kalagatur, Balu Bhasuran, Achuth Jayakrishnan, Renuka Ramalingam Manoharan, Ponmalai Kolandaivel, Jeyakumar Natarajan, and Krishna Kadirvelu
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- 2019
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104. Role of CO2 Carriers in Carbon Capture Utilization and Sequestration as A Part of Global Decarbonization Strategy
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Karthik Binu, Abhishek A. Viswanath, and Maroli Namith Raj
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General Medicine - Abstract
With the world gearing up to cut down carbon emissions to combat the greenhouse effect, a novel method has been introduced to collect and store co2 after pressurizing and liquifying it. carbon sequestered will either be put to use in industries or will be buried deep underground. this concept is highly revered due to its pragmatism and simplicity and is broadly termed as "carbon capture, utilization and sequestration/ storage (ccus)". though it is clear how to capture, utilize and store liquified co2 (lco2), the modus operandi of transportation remains abstruse. though the technical feasibility of this method is still under debate, many shipping companies have set forth to construct liquified co2 (lco2) tankers. ongoing studies are focused on finding the best methods to transport co2 by retrofitting lng ships to better equip them for storing and transporting co2. this paper takes a systematic approach to review the development of lco2 tankers. it discusses the trail of development, major challenges and limitations, technological gaps, and future prospects. it also looks over the economic and ecological aspects of such an endeavor. the paper has also taken care not to be oblivious to other options at hand, including pipelines and railways. it briefly explains the above methods and further discusses their limitations.
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- 2023
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105. Hinged Bipodal Furoylthiourea-Based Ru(II)-Arene Complexes: Effect of (ortho, meta, or para)-Substitution on Coordination and Anticancer Activity
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Srividya Swaminathan, Jebiti Haribabu, Mahendiran Dharmasivam, Nikhil Maroli, Jayachandra Prakasan Jayadharini, Nithya Balakrishnan, Nattamai Bhuvanesh, Cesar Echeverria, and Ramasamy Karvembu
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Inorganic Chemistry ,Physical and Theoretical Chemistry - Published
- 2023
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106. EFECTIVIDAD DE DIFERENTES TÉCNICAS DE REGISTRO DE ANFIBIOS EN UN HUMEDAL LACUSTRE TEMPLADO DEL CENTRO-ESTE DE ARGENTINA
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Laura Cecilia Sanchez, Yanina Prieto, Malena Maroli, and Ana Laura Ronchi Virgolini
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Animal Science and Zoology ,Ecology, Evolution, Behavior and Systematics - Abstract
Las comunidades de anuros y los componentes bióticos asociados, así como el hábitat físico circundante varían entre regiones. El éxito de las investigaciones sobre biodiversidad de anfibios dependerá entonces de conocer la eficiencia de las diferentes técnicas de muestreo que se aplican en cada ambiente particular que es analizado. En este contexto, evaluamos la efectividad relativa de registro (ERR) de cuatro técnicas diferentes en un humedal lacustre localizado en la Reserva Juan Bautista Alberdi (RJBA), en el centro-este de Argentina. Se efectuaron los relevamientos de diciembre de 2021 a marzo de 2022 (temporada de verano), sumándose un muestreo de otoño (mayo/2022). Se emplearon a) trampas de caída, b) muestreos de larvas con red, c) transectas de prospección auditiva y d) transectas de prospección visual. En cada caso, se calculó la ERR estandarizando los registros de acuerdo al esfuerzo de muestreo medido en minutos. Para estudiar el efecto de la técnica de muestreo sobre la ERR se realizó un modelo lineal randomizado mediante un test de permutación, aplicando 1,000 iteraciones. Se registraron un total de 11 especies, siendo Boana pulchella, Scinax nasicus y Rhinella dorbignyi las detectadas con mayor frecuencia. La técnica de muestreo influyó en la ERR (P = 0.001). El transecto de prospección auditiva resultó la técnica más exitosa, con una ERR del 24.44%, seguida por la búsqueda de larvas con red (3.70%) y el transecto de prospección visual (3.38%). No obstante, estas dos últimas permitieron encontrar especies no detectadas con la primera. Consecuentemente, un diseño integrando diferentes técnicas es necesario para estudiar adecuadamente las comunidades de anfibios de la RJBA. Mejorar la efectividad de los muestreos permite fortalecer nuestra comprensión sobre la biodiversidad de este grupo taxonómico, tan necesario en el contexto de declinación global actual.
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- 2023
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107. Patients’ perception about the outcomes of prosthetic treatment in Southern Brazil
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Giseli Sauer Benetti, Lara Dotto, Angélica Maroli, Fabíola Barbon, Alfonso Sanchez-Ayala, and Ataís Bacchi
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Dental prosthesis ,Education, dental ,Self Concept ,Dentistry ,RK1-715 - Abstract
Aim: this study assessed the patients’ perception of the outcomes of prosthetic treatment in a University of Southern Brazil. Methods: patients seeking for prosthetic treatment were invited to answer a questionnaire with 41 items about the potential risks, benefits, and consequences of no treatment. Answers were obtained according to a five-item Likert-scale varying from 1 (completely disagree) to 5 (completely agree). Sociodemographic data was included in the comparison. Mann-Whitney or Kruskal-Wallis (95%) compared data depending on the variable. Results: two-hundred twenty-five patients answered the questionnaire. Median age of participants was 45-54 years. The potential benefits were similar among participants irrespective of the variable adopted. The perception of risks was significant influenced by variables gender, age, education level, type of edentulous space, prior treatment with prosthodontics, type of prosthodontics, and prosthodontics usage in years. Consequences of no treatment were affected by age, prior treatment with prosthodontics, and prosthodontics usage in years. Conclusions: the study showed the fundamental importance of correct elucidation about the potential risks (negative perception) in the initial appointment for the studied population. Elucidation about the consequences of no treatment are relevant because some differences were seen into the variables. Prosthodontics patients from the city of Passo Fundo seem well informed about the benefits of the prosthetic treatment, besides the significant influence of some sociodemographic and prosthetic conditions.
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- 2020
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108. Automated rotational calibration of multiple 3D LIDAR units for intelligent vehicles.
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John Maroli, ümit özgüner, Keith A. Redmill, and Arda Kurt
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- 2017
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109. Analisis Penggunaan Dialek Tengger Pada Masyarakat Desa Ngadirejo Kecamatan Tutur dan Desa Mororejo Kecamatan Tosari (Kajian Dialektologi)
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Dwi, Windi Agustia, primary, Widayati, Wahyu, primary, Tobing, Victor Maroli Tua, primary, Utami, Sri, primary, and Haerussaleh, Haerussaleh, primary
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- 2023
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110. Riding the Wave: Unveiling the Conformational Waves from RBD of SARS-CoV-2 Spike Protein to ACE2
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Maroli, Nikhil, primary
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- 2023
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111. Diversidad de mamíferos terrestres y amenazas para su conservación en la Reserva Juan Bautista Alberdi, Oro Verde, Entre Ríos, Argentina
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Morguenstern, Quione Irene, primary, Maroli, Malena, additional, Pineda Sánchez, Abigail, additional, Zapata, Cintia Verónica, additional, Sanchez, Laura Cecilia, additional, Prieto, Yanina, additional, Tarquini, Juliana, additional, Hergenreder, Cristian, additional, Gimaux, Alfredo, additional, and Ronchi-Virgolini, Ana Laura, additional
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- 2023
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112. Benign struma ovarii-a rare monodermal ovarian teratoma-a case report
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Maroli, Rajani, primary, S., Chandni, additional, and Sasidharan, Athira, additional
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- 2023
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113. Primer registro de Burlisto Cabeza Gris (Attila phoenicurus) para la provincia del Chaco
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Almeida, Matías J., primary and Maroli, Malena, additional
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- 2023
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114. Using sacituzumab govitecan for metastatic urothelial carcinoma after prior treatment with enfortumab vedotin: A single institution experience.
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Maroli, Kimberly, primary, Wee, Christopher Eing, additional, Nizam, Amanda, additional, Ornstein, Moshe Chaim, additional, Gilligan, Timothy D., additional, Martin, Allison, additional, Bonham, Amanda, additional, Lynn, David, additional, Vyas, Neil, additional, and Gupta, Shilpa, additional
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- 2023
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115. Outcomes using enfortumab vedotin for metastatic urothelial carcinoma stratified by prior response to immunotherapy: A single institution experience.
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Wee, Christopher Eing, primary, Nizam, Amanda, additional, Ornstein, Moshe Chaim, additional, Gilligan, Timothy D., additional, Chen, Yanwen, additional, Maroli, Kimberly, additional, Martin, Allison, additional, Bonham, Amanda, additional, Lynn, David, additional, Vyas, Neil, additional, and Gupta, Shilpa, additional
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- 2023
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116. Biomechanical behavior of teeth without remaining coronal structure restored with different post designs and materials
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Maroli, Angélica, Hoelcher, Kaue Andreas Lotice, Reginato, Vagner Flavio, Spazzin, Aloisio Oro, Caldas, Ricardo Armini, and Bacchi, Atais
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- 2017
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117. A Laser Frequency Transverse Modulation Might Compensate for the Spectral Broadening Due to Large Electron Energy Spread in Thomson Sources
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Vittoria Petrillo, Illya Drebot, Geoffrey Krafft, Cesare Maroli, Andrea R. Rossi, Marcello Rossetti Conti, Marcel Ruijter, and Balša Terzić
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Compton scattering ,chirped laser ,Applied optics. Photonics ,TA1501-1820 - Abstract
Compact laser plasma accelerators generate high-energy electron beams with increasing quality. When used in inverse Compton backscattering, however, the relatively large electron energy spread jeopardizes potential applications requiring small bandwidths. We present here a novel interaction scheme that allows us to compensate for the negative effects of the electron energy spread on the spectrum, by introducing a transverse spatial frequency modulation in the laser pulse. Such a laser chirp, together with a properly dispersed electron beam, can substantially reduce the broadening of the Compton bandwidth due to the electron energy spread. We show theoretical analysis and numerical simulations for hard X-ray Thomson sources based on laser plasma accelerators.
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- 2022
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118. Multi-omics Investigation into the Mechanism of Action of an Anti-tubercular Fatty Acid Analogue
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Isin T. Sakallioglu, Amith S. Maroli, Aline De Lima Leite, Darrell D. Marshall, Boone W. Evans, Denise K. Zinniel, Patrick H. Dussault, Raúl G. Barletta, and Robert Powers
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Colloid and Surface Chemistry ,Mycolic Acids ,Bacterial Proteins ,Mycobacterium smegmatis ,Fatty Acids ,Antitubercular Agents ,Mycobacterium tuberculosis ,General Chemistry ,Biochemistry ,Catalysis - Abstract
The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were combined with a network analysis to investigate the MoA of DA-CB against
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- 2022
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119. Nanostructure Tuning of Gold Nanoparticles Films via Click Sintering.
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Urban, Massimo, Rosati, Giulio, Maroli, Gabriel, Pelle, Flavio Della, Bonini, Andrea, Sajti, Laszlo, Fedel, Mariangela, and Merkoçi, Arben
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- 2024
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120. Factors predictive of primary resistance (PrimRes) to immune checkpoint inhibitors (ICIs) in patients (pts) with metastatic urothelial cancer (mUC).
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Pramod, Nikhil, Dawsey, Scott, Patgunarajah, Ubenthira, Lynn, David, Wei, Wei, Hobeika, Charbel, Nair, Monica, Martin, Allison, Maroli, Kimberly, Ornstein, Moshe Chaim, Wee, Christopher Eing, Gilligan, Timothy D., Nizam, Amanda, Bonham, Amanda, Mian, Omar Y., Pavicic, Paul G., Diaz-Montero, C. Marcela, and Gupta, Shilpa
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- 2024
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121. Effect of neutrophil to lymphocyte ratio (NLR) on outcomes with immune checkpoint inhibitors (ICIs) in patients (pts) with metastatic urothelial carcinoma (mUC) in real-world setting.
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Lynn, David, Dawsey, Scott, Patgunarajah, Ubenthira, Pramod, Nikhil, Wei, Wei, Hobeika, Charbel, Nair, Monica, Maroli, Kimberly, Martin, Allison, Ornstein, Moshe Chaim, Wee, Christopher Eing, Gilligan, Timothy D., Nizam, Amanda, Bonham, Amanda, Mian, Omar Y., Pavicic, Paul G., Diaz-Montero, C. Marcela, and Gupta, Shilpa
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- 2024
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122. Effect of type of antibiotics (Abx) on outcomes with immune checkpoint inhibitors (ICIs) in patients (pts) with metastatic urothelial carcinoma (mUC) in a real-world setting.
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Hobeika, Charbel, Dawsey, Scott, Patgunarajah, Ubenthira, Lynn, David, Pramod, Nikhil, Wei, Wei, Nair, Monica, Maroli, Kimberly, Martin, Allison, Ornstein, Moshe Chaim, Wee, Christopher Eing, Gilligan, Timothy D., Nizam, Amanda, Bonham, Amanda, Mian, Omar Y., Pavicic, Paul G., Diaz-Montero, C. Marcela, and Gupta, Shilpa
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- 2024
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123. Effect of body mass index (BMI) on efficacy of immune checkpoint inhibitors (ICIs) in patients with metastatic urothelial carcinoma (mUC) in a real-world setting.
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Lynn, David, Hobeika, Charbel, Patgunarajah, Ubenthira, Dawsey, Scott, Pramod, Nikhil, Wei, Wei, Nair, Monica, Maroli, Kimberly, Martin, Allison, Ornstein, Moshe Chaim, Wee, Christopher Eing, Gilligan, Timothy D., Nizam, Amanda, Bonham, Amanda, Mian, Omar Y., Pavicic, Paul G., Diaz-Montero, C. Marcela, and Gupta, Shilpa
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- 2024
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124. Evaluating the requirements of communicating vehicles in collaborative automated driving.
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Guchan Ozbilgin, ümit özgüner, Onur Altintas, Haris Kremo, and John Maroli
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- 2016
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125. Rodent Abundance and Hantavirus Infection in Protected Area, East-Central Argentina
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Malena Maroli, María Victoria Vadell, Paula Padula, and Isabel E. Gómez Villafañe
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hantavirus ,viruses ,infection ,climate ,weather ,disease transmission ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We captured 3 hantavirus rodent hosts in Otamendi Natural Reserve, Argentina, during 2007–2012. Hantavirus antibodies were found only in Akodon azarae grass mice, mainly in males and old animals. Higher abundance of this species was associated with warm and rainy weather and high water levels, which peaked after a strong El Niño event.
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- 2018
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126. Distribuzione dei flebotomi (Diptera, Psychodidae) nella Sicilia orientale: primi dati di transetti di stazioni di monitoraggio dalla costa verso l'entroterra
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D'Urso, Vera, Ruta, Francesco, Khoury, Cristina, Bianchi, Riccardo, and Maroli, Michele
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- 2002
127. ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7
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Claudia Garcia-Gonzalez, Christoph Dieterich, Giovanni Maroli, Marion Wiesnet, Astrid Wietelmann, Xiang Li, Xuejun Yuan, Johannes Graumann, Konstantinos Stellos, Thomas Kubin, Andre Schneider, and Thomas Braun
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Heart Failure ,Adenosine ,Interferon-Induced Helicase, IFIH1 ,Adenosine Deaminase ,Physiology ,Interferon Regulatory Factor-7 ,NF-kappa B ,Inosine ,Mice, Mutant Strains ,Mice ,Animals ,RNA ,Interferons ,Cardiology and Cardiovascular Medicine - Abstract
Background: ADAR1 (adenosine deaminase acting on RNA-1)-mediated adenosine to inosine (A-to-I) RNA editing plays an essential role for distinguishing endogenous from exogenous RNAs, preventing autoinflammatory ADAR1 also regulates cellular processes by recoding specific mRNAs, thereby altering protein functions, but may also act in an editing-independent manner. The specific role of ADAR1 in cardiomyocytes and its mode of action in the heart is not fully understood. To determine the role of ADAR1 in the heart, we used different mutant mouse strains, which allows to distinguish immunogenic, editing-dependent, and editing-independent functions of ADAR1. Methods: Different Adar1 -mutant mouse strains were employed for gene deletion or specific inactivation of ADAR1 enzymatic activity in cardiomyocytes, either alone or in combination with Ifih1 (interferon induced with helicase C domain 1) or Irf7 (interferon regulatory factor 7) gene inactivation. Mutant mice were investigated by immunofluorescence, Western blot, RNAseq, proteomics, and functional MRI analysis. Results: Inactivation of Adar1 in cardiomyocytes resulted in late-onset autoinflammatory myocarditis progressing into dilated cardiomyopathy and heart failure at 6 months of age. Adar1 depletion activated interferon signaling genes but not NFκB (nuclear factor kappa B) signaling or apoptosis and reduced cardiac hypertrophy during pressure overload via induction of Irf7 . Additional inactivation of the cytosolic RNA sensor MDA5 (melanoma differentiation-associated gene 5; encoded by the Ifih1 gene) in Adar1 mutant mice prevented activation of interferon signaling gene and delayed heart failure but did not prevent lethality after 8.5 months. In contrast, compound mutants only expressing catalytically inactive ADAR1 in an Ifih1 -mutant background were completely normal. Inactivation of Irf7 attenuated the phenotype of Adar1 -deficient cardiomyocytes to a similar extent as Ifih1 depletion, identifying IRF7 as the main mediator of autoinflammatory responses caused by the absence of ADAR1 in cardiomyocytes. Conclusions: Enzymatically active ADAR1 prevents IRF7-mediated autoinflammatory reactions in the heart triggered by endogenous nonedited RNAs. In addition to RNA editing, ADAR1 also serves editing-independent roles in the heart required for long-term cardiac function and survival.
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- 2022
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128. Aquaporin-4 Mediated Aggregation of Alzheimer’s Amyloid β-Peptide
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Maroli, Nikhil, primary
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- 2023
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129. Assessing the Rheological, Mechanical, and Photocatalytic Properties of Niobium Oxide-Incorporated White Cement Pastes
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Silvestro, Laura, primary, Maroli, Caroline, additional, Koch, Brenda, additional, Ruviaro, Artur Spat, additional, Lima, Geannina, additional, Kempka, Mariane, additional, Marin, Camila Fabiano de Freitas, additional, Mezalira, Daniela Zambelli, additional, and Gleize, Philippe Jean Paul, additional
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- 2023
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130. Riding the Wave: Unveiling the Conformational Waves from RBD to ACE2
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Maroli, Nikhil, primary
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- 2023
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131. Advances in the surgical treatment of Crohn's disease
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Luberto, Antonio, primary, Maroli, Annalisa, additional, Carvello, Michele, additional, and Spinelli, Antonino, additional
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- 2023
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132. Finite element-based micromechanical modeling of the influence of phase properties on the elastic response of cementitious mortars
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Das, Sumanta, Maroli, Amit, and Neithalath, Narayanan
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- 2016
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133. The influence of microencapsulated phase change material (PCM) characteristics on the microstructure and strength of cementitious composites: Experiments and finite element simulations
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Aguayo, Matthew, Das, Sumanta, Maroli, Amit, Kabay, Nihat, Mertens, James C.E., Rajan, Subramaniam D., Sant, Gaurav, Chawla, Nikhilesh, and Neithalath, Narayanan
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- 2016
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134. Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR
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Colombo, Sara Francesca, Cardani, Silvia, Maroli, Annalisa, Vitiello, Adriana, Soffientini, Paolo, Crespi, Arianna, Bram, Richard F., Benfante, Roberta, and Borgese, Nica
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- 2016
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135. A microstructure-guided constitutive modeling approach for random heterogeneous materials: Application to structural binders
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Das, Sumanta, Maroli, Amit, Singh, Sudhanshu S., Stannard, Tyler, Xiao, Xianghui, Chawla, Nikhilesh, and Neithalath, Narayanan
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- 2016
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136. Ambulance referral for emergency obstetric care in remote settings
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Tsegaye, Ademe, Somigliana, Edgardo, Alemayehu, Tadesse, Calia, Federico, Maroli, Massimo, Barban, Paola, Manenti, Fabio, Putoto, Giovanni, and Accorsi, Sandro
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- 2016
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137. Minimally invasive vs. open segmental resection of the splenic flexure for cancer: a nationwide study of the Italian Society of Surgical Oncology-Colorectal Cancer Network (SICO-CNN)
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Maurizio Degiuli, Monica Ortenzi, Mariano Tomatis, Lucia Puca, Desiree Cianflocca, Daniela Rega, Annalisa Maroli, Ugo Elmore, Francesca Pecchini, Marco Milone, Roberta La Mendola, Erica Soligo, Simona Deidda, Domenico Spoletini, Diletta Cassini, Alessandra Aprile, Michela Mineccia, Herald Nikaj, Francesco Marchegiani, Fabio Maiello, Cristina Bombardini, Michele Zuolo, Michele Carlucci, Luca Ferraro, Armando Falato, Alberto Biondi, Roberto Persiani, Patrizia Marsanich, Daniele Fusario, Leonardo Solaini, Sara Pollesel, Gianluca Rizzo, Claudio Coco, Alberto Di Leo, Davide Cavaliere, Franco Roviello, Andrea Muratore, Domenico D’Ugo, Francesco Bianco, Paolo Pietro Bianchi, Paola De Nardi, Marco Rigamonti, Gabriele Anania, Claudio Belluco, Roberto Polastri, Salvatore Pucciarelli, Sergio Gentilli, Alessandro Ferrero, Stefano Scabini, Gianandrea Baldazzi, Massimo Carlini, Angelo Restivo, Silvio Testa, Dario Parini, Giovanni Domenico De Palma, Micaela Piccoli, Riccardo Rosati, Antonino Spinelli, Paolo Delrio, Felice Borghi, Marco Guerrieri, Rossella Reddavid, Degiuli, Maurizio, Ortenzi, Monica, Tomatis, Mariano, Puca, Lucia, Cianflocca, Desiree, Rega, Daniela, Maroli, Annalisa, Elmore, Ugo, Pecchini, Francesca, Milone, Marco, La Mendola, Roberta, Soligo, Erica, Deidda, Simona, Spoletini, Domenico, Cassini, Diletta, Aprile, Alessandra, Mineccia, Michela, Nikaj, Herald, Marchegiani, Francesco, Maiello, Fabio, Bombardini, Cristina, Zuolo, Michele, Carlucci, Michele, Ferraro, Luca, Falato, Armando, Biondi, Alberto, Persiani, Roberto, Marsanich, Patrizia, Fusario, Daniele, Solaini, Leonardo, Pollesel, Sara, Rizzo, Gianluca, Coco, Claudio, Di Leo, Alberto, Cavaliere, Davide, Roviello, Franco, Muratore, Andrea, D’Ugo, Domenico, Bianco, Francesco, Bianchi, Paolo Pietro, De Nardi, Paola, Rigamonti, Marco, Anania, Gabriele, Belluco, Claudio, Polastri, Roberto, Pucciarelli, Salvatore, Gentilli, Sergio, Ferrero, Alessandro, Scabini, Stefano, Baldazzi, Gianandrea, Carlini, Massimo, Restivo, Angelo, Testa, Silvio, Parini, Dario, De Palma, Giovanni Domenico, Piccoli, Micaela, Rosati, Riccardo, Spinelli, Antonino, Delrio, Paolo, Borghi, Felice, Guerrieri, Marco, and Reddavid, Rossella
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Segmental resection ,Minimally invasive surgery ,Colon cancer ,Laparoscopic resection ,Open surgery ,Splenic flexure cancer ,Surgery - Abstract
Background Evidence on the efficacy of minimally invasive (MI) segmental resection of splenic flexure cancer (SFC) is not available, mostly due to the rarity of this tumor. This study aimed to determine the survival outcomes of MI and open treatment, and to investigate whether MI is noninferior to open procedure regarding short-term outcomes. Methods This nationwide retrospective cohort study included all consecutive SFC segmental resections performed in 30 referral centers between 2006 and 2016. The primary endpoint assessing efficacy was the overall survival (OS). The secondary endpoints included cancer-specific mortality (CSM), recurrence rate (RR), short-term clinical outcomes (a composite of Clavien-Dindo > 2 complications and 30-day mortality), and pathological outcomes (a composite of lymph nodes removed ≧12, and proximal and distal free resection margins length ≧ 5 cm). For these composites, a 6% noninferiority margin was chosen based on clinical relevance estimate. Results A total of 606 patients underwent either an open (208, 34.3%) or a MI (398, 65.7%) SFC segmental resection. At univariable analysis, OS and CSM were improved in the MI group (log-rank test p = 0.004 and Gray’s tests p = 0.004, respectively), while recurrences were comparable (Gray’s tests p = 0.434). Cox multivariable analysis did not support that OS and CSM were better in the MI group (p = 0.109 and p = 0.163, respectively). Successful pathological outcome, observed in 53.2% of open and 58.3% of MI resections, supported noninferiority (difference 5.1%; 1-sided 95%CI − 4.7% to ∞). Successful short-term clinical outcome was documented in 93.3% of Open and 93.0% of MI procedures, and supported noninferiority as well (difference − 0.3%; 1-sided 95%CI − 5.0% to ∞). Conclusions Among patients with SFC, the minimally invasive approach met the criterion for noninferiority for postoperative complications and pathological outcomes, and was found to provide results of OS, CSM, and RR comparable to those of open resection.
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- 2023
138. Assessing the Rheological, Mechanical, and Photocatalytic Properties of Niobium Oxide-Incorporated White Cement Pastes
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Laura Silvestro, Caroline Maroli, Brenda Koch, Artur Spat Ruviaro, Geannina Lima, Mariane Kempka, Camila Fabiano de Freitas Marin, Daniela Zambelli Mezalira, and Philippe Jean Paul Gleize
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niobium ,cement ,photocatalytic ,rheology ,hydration ,General Materials Science - Abstract
Niobium oxide (Nb2O5) is a semiconductor that exhibits photocatalytic properties, making it potentially valuable in addressing air pollution, self-cleaning, and self-disinfection in cement-based materials (CBMs). Therefore, this study aimed to evaluate the impact of different Nb2O5 concentrations on various parameters, including rheological characteristics, hydration kinetics (measured using isothermal calorimetry), compressive strength, and photocatalytic activity, specifically in the degradation of Rhodamine B (RhB) in white Portland cement pastes. The incorporation of Nb2O5 increased the yield stress and viscosity of the pastes by up to 88.9% and 33.5%, respectively, primarily due to the larger specific surface area (SSA) provided by Nb2O5. However, this addition did not significantly affect the hydration kinetics or the compressive strength of the cement pastes after 3 and 28 days. Tests focusing on the degradation of RhB in the cement pastes revealed that the inclusion of 2.0 wt.% of Nb2O5 was insufficient to degrade the dye when exposed to 393 nm UV light. However, an interesting observation was made concerning RhB in the presence of CBMs, as it demonstrated a degradation mechanism that was not dependent on light. This phenomenon was attributed to the production of superoxide anion radicals resulting from the interaction between the alkaline medium and hydrogen peroxide.
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- 2023
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139. Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling
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Sreenath Reddy Nayakanti, Aleksandra Friedrich, Poonam Sarode, Leili Jafari, Giovanni Maroli, Mario Boehm, Alice Bourgeois, Yann Grobs, Fatemeh Khassafi, Carsten Kuenne, Stefan Guenther, Swati Dabral, Jochen Wilhelm, Astrid Weiss, Astrid Wietelmann, Baktybek Kojonazarov, Wiebke Janssen, Mario Looso, Frances de Man, Steeve Provencher, Khodr Tello, Werner Seeger, Sebastien Bonnet, Rajkumar Savai, Ralph T. Schermuly, Soni Savai Pullamsetti, Pulmonary medicine, and ACS - Pulmonary hypertension & thrombosis
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Physiology ,Cardiology and Cardiovascular Medicine - Abstract
Background: The ability of the right ventricle (RV) to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. At present, there are no specific treatments available to prevent RV failure, except for heart/lung transplantation. The wingless/int-1 (Wnt) signaling pathway plays an important role in the development of the RV and may also be implicated in adult cardiac remodeling. Methods: Molecular, biochemical, and pharmacological approaches were used both in vitro and in vivo to investigate the role of Wnt signaling in RV remodeling. Results: Wnt/β-catenin signaling molecules are upregulated in RV of patients with pulmonary arterial hypertension and animal models of RV overload (pulmonary artery banding-induced and monocrotaline rat models). Activation of Wnt/β-catenin signaling leads to RV remodeling via transcriptional activation of FOSL1 and FOSL2 (FOS proto-oncogene [FOS] like 1/2, AP-1 [activator protein 1] transcription factor subunit). Immunohistochemical analysis of pulmonary artery banding -exposed BAT-Gal (β-catenin-activated transgene driving expression of nuclear β-galactosidase) reporter mice RVs exhibited an increase in β-catenin expression compared with their respective controls. Genetic inhibition of β-catenin, FOSL1/2, or WNT3A stimulation of RV fibroblasts significantly reduced collagen synthesis and other remodeling genes. Importantly, pharmacological inhibition of Wnt signaling using inhibitor of PORCN (porcupine O-acyltransferase), LGKK-974 attenuated fibrosis and cardiac hypertrophy leading to improvement in RV function in both, pulmonary artery banding - and monocrotaline-induced RV overload. Conclusions: Wnt- β-Catenin-FOSL signaling is centrally involved in the hypertrophic RV response to increased afterload, offering novel targets for therapeutic interference with RV failure in pulmonary hypertension.
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- 2023
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140. Advances in the surgical treatment of Crohn's disease
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Antonio Luberto, Annalisa Maroli, Michele Carvello, and Antonino Spinelli
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- 2023
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141. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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S., Toma T., Wadood Q., Yip J., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ainger E., Busti S., Cunliffe L., Flamini T., Gaffing S., Moorcroft C., Peter M., Simpson L., Stokes E., Stott G., Wilson J., York J., Yousaf A., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Brown M., Goaman A., Hodgson B., Ijeomah A., Iroegbu U., Kaur G., Lowe C., Mahmood S., Sattar Z., Sen P., Szuman A., Abbas N., Anto N., Bhome R., Eccles L., Elliott J., Hughes E. J., Jones A., Karunatilleke A. S., Knight J. S., Manson C. C. F., Mekhail I., Michaels L., Noton T. M., Okenyi E., Reeves T., Yasin I. H., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Banfield D. A., Harris R., Mason-Apps C., Roe T., Sandhu J., Shafiq N., Stickler E., Tam J. P., Williams L. 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M., Rogers A., Roy C., Rutherford D., Smith F., Zubikarai G., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Al-Khudairi R., Bamford M., Chang M., Cheng J., Hedley C., Joseph R., Mitchell B., Rothwell L., Siddiqui A., Smith J., Taylor K., Wroe Wright O., Zaman S., Hajiev S., Ross T., Baryan H. K., Boyd G., Conchie H., Cox L., Hill N., Krishna K., Lakin F., Scotcher S., Owen M., Crisp E., Thompson C., Alberts J., Asad M., Barraclough J., Marshall D., Wakeford W., Cronbach P., D'Souza F., Gammeri E., Houlton J., Hall M., Kethees A., Patel R., Perera M., Shaid M., Webb E., Saiyed A., Charalambous A., Hollywood J. L., Hammond R. F. L., Beattie S., Chadwick M., El-Taji O., Haddad S., Mann M., Popat K., Rimmer L., Riyat H., Smith H., Matthews J., Mendonca V., Spinty J., Glynn N., Muhammad U., Anderson L., Anandarajah C., Cipparrone M., Desai K., Gao C., Goh E. 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E., Kechagias A., Turunen A., Katunin J., Niskakangas M., Ojakaar A., Venara A., LeNaoures P., Duchalais E., Vignaud T., Frey S., Ricolleau C., Ioannidis A., Konstantinidis M., Antonakopoulos F., Mathioulaki A., Chrysoheris P., Athanasopoulos P. G., Koutserimpas C., Tenconi S. M., Rausei S., Maioli D., Marchionini V., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., Tirelli F., Fico V., Santullo F., Belia F., Schaeff V., Otto A., Jakubauskas M., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Poskus T., Jotautas V., Strupas K., Petrulionis M., van Elst T. R., Abdulrahman Z., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Soares A., Aparicio D. J., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Juloski J., Cuk V. V., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Jovanovic M., El Kasmy El Kasmi Y., Gomez Jurado M. 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S., White S., Ivanov V., Borisova A., Kuncarova K., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Kolosova B., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Chrz K., Antonova T., Chodora S., Houdek O., Novicky R., Skalicky A., Farkasova M., Jozaf V., Klail T., Prochazka V., Harbjerg J. L., Enevoldsen M., Hojgaard Pedersen J., Brandsborg S., Amiri S., Brinck S., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Kjaer M. D., Unbehaun K. P., Mark-Christensen A., Dalsgaard P., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Ravn S., Lycke K. D., Kristensen F. P., Bonnerup K., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Krupp J., Alhalabi O., Sliwinski S., Gablenz E., Seiboldt T., Beck L., Pohl L. 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E., Sagnotta A., Di Cintio A., Gemini A., Trastulli S., De Luca M., Desiderio J., Gubbiotti F., Campagnaro T., Pedrazzani C., Turri G., Lazzarini E., Conti C., Ruzzenente A., Petrelli F., Marziali I., Mazzocato S., Vergari R., Piazzai F., Kubolli I., Aggiusti A., Paolucci A., Ortenzi M., Gallo G., Clerico G., De Santi G., Bitonti M. F., Trompetto M., Realis Luc A., Papandrea M., Cerra C., Pirillo M., Cravano S., Libri I., Laquatra N., Isabello A., De Luca E., Testa V., Morino M., Mistrangelo M., Sinibaldi G., Angelucci G. P., Scaramuzzo R., Larcinese A., Fioriti C., Picone E., Nardi M., Di Candido F., Spinelli A., Marco M., Bevilacqua M., Maroli A., Colombo F., Cigognini M., Zaffaroni G., Maffioli A., Colombo S., Bondurri A., Sampietro G., Foschi D., Perrone G., Bonati E., Aresu S., Saba A., Biancafarina A., Angelini M., Andolfi E., Miranda E., Scricciolo M., Provenza G., Cavallina G., Frezza B., Fontani A., Malatesti R., Pellicano G. A., Ceccarelli G., Canonico G., Falsetti E., Pagnanelli M., De Nardi P., Rosati R., Marcocci G., Vignali A., Quattromani R., Curletti G., Galleano R., Malerba M., Percivale A., Ghazouani O., Reggiani L., Spirito C., Bini R., de Manzoni Garberini A., Impellizzeri H., Moretto G., Bacchion M., Casaril A., Inama M., Creciun M., Vitali M., Cillara N., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Loche G. A., Tutino R., Licari L., Campanella S., Profita G., Falco N., Rotolo G., Venturelli P., De Marco P., Marciano M., Picciariello A., Chetta N., Aquilino F., Papagni V., Coletta D., Cerasari S., Galiffa G., Lapolla P., Del Basso C., Cirillo B., De Toma G., Fazzi K., Bini S., De Padua C., Savino G., Finotti E., Ferrara F., Stella M., Gobatti D., Tamini N., Brenna R., Giani A., Tirotta F., Famularo S., Angrisani M., Ceresoli M., Talamo G., Sucameli F., Gennai A., Moggia E., Bianchi C., Bonfante P., Macina S., Feleppa C., Imperatore M., Berti S., Parini D., Lanari J., Giamundo P., Lo Conte A., Pagano G., Manigrasso M., Danzi M., Amato R., Anastasio L., Mastella F., Basile R., Peltrini R., Marra E., Luglio G., Giglio M., Anoldo P., Vertaldi S., Grimaldi L., Tammaro N., Ripetti V., D'Alessio R., Benvenuto D., Pesce A., Menduni N., Giudicissi R., Zalla T., Baraghini M., Romoli L., Calussi M., Vellei S., Genzano C., Feroci F., Vita M., Giani I., Goldin E., Ciccioli E., Galgano A., Zuin M., Bettella A., Barina A., Vendramin E., Palano G., Schiavone D., Rega D., La Manna V., Migliore G., Aversano A., Fares Bucci A., Belli A., Andriola V., Lafranceschina S., Gordini L., Erdas E., Podda F., Cappellacci F., Salaris C., Sanna S., Marcialis J., Longheu A., Foppa C., Coratti F., Montanelli P., Grandi S., Nelli T., Ben Khaled N., Cammelli F., Ferrini E., Billo M. E., Piccolo G., Romano S., Gaetano P., Pilotta F., Baldassarre L., Birindelli A., D'Errico U., Bianchini S., Ferrari C., Franceschi A., Caristo G., Ballarini Z., Romelli M., Ruggiero S., Percassi A., Milone M., De Rosa M., Pipitone Federico N. S., Molteni B., Magri Piccinini A., Tilocca P. L., Marrosu A. G., Scognamillo F., Pala C., Attene F., Carboni L., Ruggiu M. W., Gabbas G., Sancini G., Roggiani A., Balsamo F., Gori A., Cuicchi D., Vittori L., Piozzi G. N., Tringali D., Bevilacqua E., Panizzo V., Lauretta A., Poillucci G., Mulas S., Simcikas D., Samalavicius N. E., Nutautiene V., Zeromskas P., Jurgaitis J., Aliosin O., Slepavicius A., Eismontas V., Kybransiene M., Portelli L., Cachia C., Cefai C., Youssef Y., Degaetano D., Debono S., Sammut M., Cassar J., Sammut K., Andrejevic P., van Wijnbergen J. W. M., Dinger T. L., ten Doesschate S. F. H., van Dalen A. S. H. M., Looijen R. C., Becker M. A. J., Comert D., Stellingwerf M. E., Abdulrahman N., van den Bos D. D., Gruter A., Vroom Y., Voeten D. M., Feenstra T., de Roy van Zuidewijn D., Hansmann M., Nasimi B., Gerdsen M., Stijns R. C. H., Leow T. Y. S., Penningnieuwland G., Davids J., Medina Feliz J., Kuiper S. Z., Sluijpers N. R. F., van de Pas K. G. H., Pruijssers S. R., Molenaar C. J. L., Thomas G., Farik S., Chen S. Y., Kilpatrick K., Kim D. H., Ong H. I., Elliott B. M., Geneta V. P., Alsadat R., Cherry R., Chapman D. A., Singh N., Clucas A., Gatenby G., Kelly B., Ruppeldt P., McIntosh N. D., Li Y., Wilton S., McLaughlin S. J. P., Kearney J., Sprosen H., Kerckhoffs P., Kandelaki H., Welman D., Coulter J., Morreau M., Li E., Rankin A., Winders J., Skipworth C., Peng S. L., Campbell S., Lim Y. K., Yassaie S. S., Dixon S., Yassaie S., Murray M., Haran C., Koh S., Wilms H., Dalzell F., Tewhaiti-Smith J., Kader T., Yam S. T., Dahya D., Hardie Boys M., Fleischl W., Desmond B., Tan J., Skavysh A., Castro J., Orelhas L., Santos J., Pacheco A., Rocha A. F., Jervis M. 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R., Claassen L., Van Vuuren S., Marx M., Kruger C., Weyers J., Lecler J., Nshalati Salvation M., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Muriel P., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Cerdan C., Jimenez Vinas C., Alconchel F., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Abrisqueta J., Esteban Sinovas O., Fairen Oro C., Lopez Otero M., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Paniagua Garcia Senorans M., Figueroa Jimenez S., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. 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L., Castro Diez L., Mosquera Fernandez C., Fernandez P., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Diaz Padillo A., Padilla Zegarra E. D., Franco M., Martinez A., Forero-Torres A., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Alberdi San Roman I., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., Salvador Roses H., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Gomez Romeu N., Merayo Alvarez M., Alonso Batanero E., Cifrian Canales I., Villarejo Campos P., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Estaire Gomez M., Lopes Moreira C. C., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Enriquez-Navascues J. M., Uriol Peralta P., Lima Pinto F., Nunez O'Sullivan S., Serrano Navidad M., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Collado-Roura F., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., Garcia J. M., Gil A., Giordano H. E., Perez Guarinos C. V., Blaser B., Imadalou L., Piazza G., Teixeira H., Pittet O., Gaspar S., Gagliardi B., Haller M. L., Huot A., Yurdaor S. S., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Biyiklioglu O., Kopac O., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Karabulut K., Uyanik A., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Kuyumcu O. F., Kutluk F., Tunc E., Ozmen B. B., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. 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E., Demirci K., Suresh G., Anbarasan J., Rehman S., Hu E., Timms S., Reynolds W., Hotchkies A., Misra V., Finch B. J., Philip Rajathasan T., Jeddy H., Kyaw H. A., Wong N., Bhahirathan Y., Donaldson C., Sequeira Campos M., Armitage M. N., Hussain A. S., Hardy B., Hassan Serry M. Y., Herron J., Thakrar C., Rojoa D., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., James A., Bugelli M., Chechelnitskaya Y., Bylinski T., Findlay J. M., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S. I., Menon G., Sloper W., Burford C., Coey J., Akbari K., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Can B., Cesmeli E., Kus D., Kavar R. C., Cevlik A. D., Cengiz U., Turk E. G., Yilmaz I., Yumurtaci O., Emin A., Girit C., Yildirak M. K., Senyigit E., Guldag A., Soyleyici B., Aytin Y. E., Akay F. E., Iskan N. G., Mutlu B., Sunay A. O., Bell T., Limnatitou D., Gormley S., Taleongpong P., Patel V., Macgregor L., Amini S., Turner C., To N., Laurence N., Green C., Frostick R., Khera R., Povey M., Mahapatra S., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Ng M. P. E., Wong R. T. W., Maese S., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Martin H., McClarty C., Sanyal S., Alsaif A., Bhopal S., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Trussell S., Chowdhury H., Alawode D. O. 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P., Giannella A., Santangelo M., Frangella F., Magagnano D., Liberatore P., Rondelli F., Castagnoli G., Bartoli A., Bellochi R., Spaziani A., Conti D., Poponesi V., Trippetti M., Amicucci S., Tazza G., Procacci P., Giovannini F., Basile E., Moschetta G., Cosmi F., Romeo G., Gasparrini M., Virgilio E., Sparta C., Mura F. A., Barmina M., Lorettu A., Rettaroli C., Mastino G., Ruggiu G. V., Mura G. A., Perrone B. A., De Angelis M., Mereu A., Adamo V., Bianco C., Ricciardiello M., Campanaro C., Panaccio P., Esposito L. M., Di Mola F. F., D'Ascanio F., Pietroletti R., Di Marco F., Amico A., Schembari E., Puglisi S., Tuminello F., Figa F., Caiazzo A., Selvaggi L., Capozzolo A., Braccio B., Truskovs A., Bartnick A., Malcevs E., Machatschek M. J., Alm J., Lapsa S., Delorme M., Zeynalov F., Larnovskis J., Sauka J., Bodrov D., Gailumsis R., Wiemann A. M., Muller N. L., Jelovskis I., Deksnis D., Bauermeister Potts O., Slimbajevs T., Ancans G., Dulskas A., Kuliavas J., Kavaliauskas P., Kavaliauskaite R., te Molder L., Tromp J., Matthee E., Tissen Y. M., Brinkhuis E., de Vries H. S., t Hart E., Beckers K., Bekker Y., Kakar S., van Smaalen T. C., Veen O. C., Dingemans S. A., van den Brink L. C., Vijgen G. H. E. J., van de Voort E. M. F., van der Pool A., van Rest K. L. C., Haak T., Gordinou de Gouberville M. C., Saleh S., Mens M. A., Hoeks E. M., Nieuwenhuizen S., Brandsma A. M., van Praag E. M., Westerduin E., Smit M. P. C. M., van der Lely S. J., de Ruiter A., Ribbers T., Aarts C. A. M., Tulek M. S., de Jonge J., Kocak S., Alqethami H. J., Constansia R., van Elst P. C., Tissink M. W., Azzahhafi J., Bofarid S., Kip M., Saleh W., Franssen S., Boon C. L., Franssen R. J. M., Romaen I., Jense M. T. F., D'Souza J., Pascoe R., Scott A., Stark E., Mulholland K., Lau W. K., Smith B., Adams S. I. B., Shah N., Ling E., Young J., Hawkins R., Jacobson A., Macfater H., Stanfield B., Henderson N., Chuang A., Maskill L., Ker H., Mouldey K., Hu R., Matthews C., Aitken E., Walker M., Winstanley J., Miguel I., Martins J., Cunha M. F., Melo J., Veiga D. N., Rachadell J., Amorim E., Vareda R., Roseira J., Americano M., Correia D., Capella V., Moinhos T., Costa F., Gil I., Morgado J., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., O'Connor D. B., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Hoo M., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Gopaul A., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Scanlon K., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., O'Dwyer N., Mana O. C., Gomez H., Riba L., Perez J., Centeno A., Ortega C., Ossola M. E., Camarero E., Martinez Illan M., Aranda Garcia L., Lazaro Cardona M., Montalvo Olmedo C., Izquierdo Moreno A., Cuenca Ramirez A., Margarida A., Pando B., Liquete Marin L., Perez Calle M., Ramos Cordero M. J., Sagredo Cuartango A., Sanchez E., Marcos Rodrigo A., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., De La Llave Serralvo A., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Tonchev P., Tamosiunas A., Rottier S. J., Negoi I., Bernado I. 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Ojofeitimi, O, Carroll, L, Hylands, A, Delaugere, L, Reveendran, D, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, Mccann, C, Stewart, R, Vara, S, Coulter, C, Ralston, C, Laverty, L, Gallagher, P, Ajibola-Taylor, O, Andah, E, Ani, C, Cabdi, N, Ito, G, Jones, M, Komoriyama, A, Titu, L, Ahmed, A, Yeo, Y, Elliott, D, Bennett, J, Mcnamara, M, Sivarajah, S, Dunmore, C, Basra, M, Gallogly, P, Harinath, G, Leong, S, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, Looi, W, Ng, J, Farhan-Alanie, M, Aitken, G, Nair, M, Aly, M, Buari, M, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Shankar Babu, V, Ahmed, K, Sheikh, Z, Monks, M, Lehmann, J, Rotimi, O, Hussain, M, Joji, N, Lovett, B, Mownah, H, Dwyer-Hemmings, L, Busuttil, A, Powell, J, Hensher, C, Vivian, F, Ali, B, Cresswell, B, Dhillon, A, Dupaguntla, Y, Hungwe, C, Lowe-Zinola, J, Tsang, J, Wcislo, K, Bevan, K, Cardus, 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S., Toma T., Wadood Q., Yip J., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ainger E., Busti S., Cunliffe L., Flamini T., Gaffing S., Moorcroft C., Peter M., Simpson L., Stokes E., Stott G., Wilson J., York J., Yousaf A., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Brown M., Goaman A., Hodgson B., Ijeomah A., Iroegbu U., Kaur G., Lowe C., Mahmood S., Sattar Z., Sen P., Szuman A., Abbas N., Anto N., Bhome R., Eccles L., Elliott J., Hughes E. J., Jones A., Karunatilleke A. S., Knight J. S., Manson C. C. F., Mekhail I., Michaels L., Noton T. M., Okenyi E., Reeves T., Yasin I. H., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Banfield D. A., Harris R., Mason-Apps C., Roe T., Sandhu J., Shafiq N., Stickler E., Tam J. P., Williams L. 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M., Rogers A., Roy C., Rutherford D., Smith F., Zubikarai G., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Al-Khudairi R., Bamford M., Chang M., Cheng J., Hedley C., Joseph R., Mitchell B., Rothwell L., Siddiqui A., Smith J., Taylor K., Wroe Wright O., Zaman S., Hajiev S., Ross T., Baryan H. K., Boyd G., Conchie H., Cox L., Hill N., Krishna K., Lakin F., Scotcher S., Owen M., Crisp E., Thompson C., Alberts J., Asad M., Barraclough J., Marshall D., Wakeford W., Cronbach P., D'Souza F., Gammeri E., Houlton J., Hall M., Kethees A., Patel R., Perera M., Shaid M., Webb E., Saiyed A., Charalambous A., Hollywood J. L., Hammond R. F. L., Beattie S., Chadwick M., El-Taji O., Haddad S., Mann M., Popat K., Rimmer L., Riyat H., Smith H., Matthews J., Mendonca V., Spinty J., Glynn N., Muhammad U., Anderson L., Anandarajah C., Cipparrone M., Desai K., Gao C., Goh E. 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E., Kechagias A., Turunen A., Katunin J., Niskakangas M., Ojakaar A., Venara A., LeNaoures P., Duchalais E., Vignaud T., Frey S., Ricolleau C., Ioannidis A., Konstantinidis M., Antonakopoulos F., Mathioulaki A., Chrysoheris P., Athanasopoulos P. G., Koutserimpas C., Tenconi S. M., Rausei S., Maioli D., Marchionini V., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., Tirelli F., Fico V., Santullo F., Belia F., Schaeff V., Otto A., Jakubauskas M., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Poskus T., Jotautas V., Strupas K., Petrulionis M., van Elst T. R., Abdulrahman Z., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Soares A., Aparicio D. J., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Juloski J., Cuk V. V., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Jovanovic M., El Kasmy El Kasmi Y., Gomez Jurado M. 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S., White S., Ivanov V., Borisova A., Kuncarova K., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Kolosova B., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Chrz K., Antonova T., Chodora S., Houdek O., Novicky R., Skalicky A., Farkasova M., Jozaf V., Klail T., Prochazka V., Harbjerg J. L., Enevoldsen M., Hojgaard Pedersen J., Brandsborg S., Amiri S., Brinck S., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Kjaer M. D., Unbehaun K. P., Mark-Christensen A., Dalsgaard P., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Ravn S., Lycke K. D., Kristensen F. P., Bonnerup K., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Krupp J., Alhalabi O., Sliwinski S., Gablenz E., Seiboldt T., Beck L., Pohl L. 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E., Sagnotta A., Di Cintio A., Gemini A., Trastulli S., De Luca M., Desiderio J., Gubbiotti F., Campagnaro T., Pedrazzani C., Turri G., Lazzarini E., Conti C., Ruzzenente A., Petrelli F., Marziali I., Mazzocato S., Vergari R., Piazzai F., Kubolli I., Aggiusti A., Paolucci A., Ortenzi M., Gallo G., Clerico G., De Santi G., Bitonti M. F., Trompetto M., Realis Luc A., Papandrea M., Cerra C., Pirillo M., Cravano S., Libri I., Laquatra N., Isabello A., De Luca E., Testa V., Morino M., Mistrangelo M., Sinibaldi G., Angelucci G. P., Scaramuzzo R., Larcinese A., Fioriti C., Picone E., Nardi M., Di Candido F., Spinelli A., Marco M., Bevilacqua M., Maroli A., Colombo F., Cigognini M., Zaffaroni G., Maffioli A., Colombo S., Bondurri A., Sampietro G., Foschi D., Perrone G., Bonati E., Aresu S., Saba A., Biancafarina A., Angelini M., Andolfi E., Miranda E., Scricciolo M., Provenza G., Cavallina G., Frezza B., Fontani A., Malatesti R., Pellicano G. A., Ceccarelli G., Canonico G., Falsetti E., Pagnanelli M., De Nardi P., Rosati R., Marcocci G., Vignali A., Quattromani R., Curletti G., Galleano R., Malerba M., Percivale A., Ghazouani O., Reggiani L., Spirito C., Bini R., de Manzoni Garberini A., Impellizzeri H., Moretto G., Bacchion M., Casaril A., Inama M., Creciun M., Vitali M., Cillara N., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Loche G. A., Tutino R., Licari L., Campanella S., Profita G., Falco N., Rotolo G., Venturelli P., De Marco P., Marciano M., Picciariello A., Chetta N., Aquilino F., Papagni V., Coletta D., Cerasari S., Galiffa G., Lapolla P., Del Basso C., Cirillo B., De Toma G., Fazzi K., Bini S., De Padua C., Savino G., Finotti E., Ferrara F., Stella M., Gobatti D., Tamini N., Brenna R., Giani A., Tirotta F., Famularo S., Angrisani M., Ceresoli M., Talamo G., Sucameli F., Gennai A., Moggia E., Bianchi C., Bonfante P., Macina S., Feleppa C., Imperatore M., Berti S., Parini D., Lanari J., Giamundo P., Lo Conte A., Pagano G., Manigrasso M., Danzi M., Amato R., Anastasio L., Mastella F., Basile R., Peltrini R., Marra E., Luglio G., Giglio M., Anoldo P., Vertaldi S., Grimaldi L., Tammaro N., Ripetti V., D'Alessio R., Benvenuto D., Pesce A., Menduni N., Giudicissi R., Zalla T., Baraghini M., Romoli L., Calussi M., Vellei S., Genzano C., Feroci F., Vita M., Giani I., Goldin E., Ciccioli E., Galgano A., Zuin M., Bettella A., Barina A., Vendramin E., Palano G., Schiavone D., Rega D., La Manna V., Migliore G., Aversano A., Fares Bucci A., Belli A., Andriola V., Lafranceschina S., Gordini L., Erdas E., Podda F., Cappellacci F., Salaris C., Sanna S., Marcialis J., Longheu A., Foppa C., Coratti F., Montanelli P., Grandi S., Nelli T., Ben Khaled N., Cammelli F., Ferrini E., Billo M. 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- Abstract
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results: In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specif
- Published
- 2022
142. Roedores urbanos de la ciudad de Diamante, Entre Ríos, Argentina
- Author
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Maroli, Malena and Gómez Villafañe, Isabel Elisa
- Published
- 2021
- Full Text
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143. Scalable Pillar[5]arene-Integrated Poly(arylate-amide) Molecular Sieve Membranes to Separate Light Gases
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Woochul Song, Jaesung Park, Subhadeep Dasgupta, Chenhao Yao, Nikhil Maroli, Harekrushna Behera, Xinyang Yin, Durga P. Acharya, Xueyi Zhang, Cara M. Doherty, Prabal K. Maiti, Benny D. Freeman, and Manish Kumar
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General Chemical Engineering ,Materials Chemistry ,General Chemistry - Published
- 2022
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144. Long-Term Outcomes of the Excluded Rectum in Crohn’s Disease: A Multicenter International Study
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Gassan Kassim, Clara Yzet, Nilendra Nair, Anketse Debebe, Alexa Rendon, Jean-Frédéric Colombel, Cindy Traboulsi, David T Rubin, Annalisa Maroli, Elisabetta Coppola, Michele M Carvello, Nadat Ben David, Francesca De Lucia, Matteo Sacchi, Silvio Danese, Antonino Spinelli, Meike M C Hirdes, Joren ten Hove, Bas Oldenburg, Aurada Cholapranee, Maxine Riter, Dana Lukin, Ellen Scherl, Esen Eren, Keith S Sultan, Jordan Axelrad, and David B Sachar
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Clinical Research ,Gastroenterology ,Immunology and Allergy - Abstract
Many patients with Crohn's disease (CD) require fecal diversion. To understand the long-term outcomes, we performed a multicenter review of the experience with retained excluded rectums.We reviewed the medical records of all CD patients between 1990 and 2014 who had undergone diversionary surgery with retention of the excluded rectum for at least 6 months and who had at least 2 years of postoperative follow-up.From all the CD patients in the institutions' databases, there were 197 who met all our inclusion criteria. A total of 92 (46.7%) of 197 patients ultimately underwent subsequent proctectomy, while 105 (53.3%) still had retained rectums at time of last follow-up. Among these 105 patients with retained rectums, 50 (47.6%) underwent reanastomosis, while the other 55 (52.4%) retained excluded rectums. Of these 55 patients whose rectums remained excluded, 20 (36.4%) were symptom-free, but the other 35 (63.6%) were symptomatic. Among the 50 patients who had been reconnected, 28 (56%) were symptom-free, while 22(44%) were symptomatic. From our entire cohort of 197 cases, 149 (75.6%) either ultimately lost their rectums or remained symptomatic with retained rectums, while only 28 (14.2%) of 197, and only 4 (5.9%) of 66 with initial perianal disease, were able to achieve reanastomosis without further problems. Four patients developed anorectal dysplasia or cancer.In this multicenter cohort of patients with CD who had fecal diversion, fewer than 15%, and only 6% with perianal disease, achieved reanastomosis without experiencing disease persistence.Patients with distal Crohn’s disease often undergo colon resection with a stoma to divert the intestinal stream from the rectum in hopes of achieving sufficient healing to allow ultimate re-establishment of intestinal continuity. Patients and practitioners alike should be aware of the long-term success rates of this procedure. Our retrospective study of 197 patients found that half required later proctectomy and an additional one-quarter remained symptomatic with excluded rectums. Only 14% remained symptom-free after reanastomosis, and only 6% if perianal disease was the initial surgical indication. These data provide estimation of long-term surgical outcomes.
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- 2022
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145. Long-Term Outcomes of the Excluded Rectum in Crohn's Disease: A Multicenter International Study
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MS MDL 1, Unit Opleiding MDL, Cancer, Infection & Immunity, Kassim, Gassan, Yzet, Clara, Nair, Nilendra, Debebe, Anketse, Rendon, Alexa, Colombel, Jean-Frédéric, Traboulsi, Cindy, Rubin, David T, Maroli, Annalisa, Coppola, Elisabetta, Carvello, Michele M, Ben David, Nadat, De Lucia, Francesca, Sacchi, Matteo, Danese, Silvio, Spinelli, Antonino, Hirdes, Meike M C, Ten Hove, Joren, Oldenburg, Bas, Cholapranee, Aurada, Riter, Maxine, Lukin, Dana, Scherl, Ellen, Eren, Esen, Sultan, Keith S, Axelrad, Jordan, Sachar, David B, MS MDL 1, Unit Opleiding MDL, Cancer, Infection & Immunity, Kassim, Gassan, Yzet, Clara, Nair, Nilendra, Debebe, Anketse, Rendon, Alexa, Colombel, Jean-Frédéric, Traboulsi, Cindy, Rubin, David T, Maroli, Annalisa, Coppola, Elisabetta, Carvello, Michele M, Ben David, Nadat, De Lucia, Francesca, Sacchi, Matteo, Danese, Silvio, Spinelli, Antonino, Hirdes, Meike M C, Ten Hove, Joren, Oldenburg, Bas, Cholapranee, Aurada, Riter, Maxine, Lukin, Dana, Scherl, Ellen, Eren, Esen, Sultan, Keith S, Axelrad, Jordan, and Sachar, David B
- Published
- 2023
146. The cleanroom-free, cheap, and rapid fabrication of nanoelectrodes with low zM limits of detection
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Generalitat de Catalunya, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, University of the Philippines, Fundación Carolina, Universidad Autónoma de Barcelona, Maroli, Gabriel, Abarintos, Vernalyn, Piper, Andrew, Merkoçi, Arben, Generalitat de Catalunya, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, University of the Philippines, Fundación Carolina, Universidad Autónoma de Barcelona, Maroli, Gabriel, Abarintos, Vernalyn, Piper, Andrew, and Merkoçi, Arben
- Abstract
Nanoscale electrodes have been a topic of intense research for many decades. Their enhanced sensitivities, born out of an improved signal-to-noise ratio as electrode dimensions decrease, make them ideal for the development of low-concentration analyte sensors. However, to date, nanoelectrode fabrication has typically required expensive equipment and exhaustive, time-consuming fabrication methods that have rendered them unsuitable for widespread use and commercialization. Herein, a method of nanoband electrode fabrication using low cost materials and equipment commonly found in research laboratories around the world is reported. The materials' cost to produce each nanoband is less than €0.01 and fabrication of a batch takes less than 1 h. The devices can be made of flexible plastics and their designs can be quickly and easily iterated. Facile methods of combining these nanobands into powerful devices, such as complete three-electrode systems, are also displayed. As a proof of concept, the electrodes are functionalized for the detection of a DNA sequence specific to SARS-CoV-2 and found to display single molecule sensitivity.
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- 2023
147. The Cleanroom‐Free, Cheap, and Rapid Fabrication of Nanoelectrodes with Low zM Limits of Detection.
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Maroli, Gabriel, Abarintos, Vernalyn, Piper, Andrew, and Merkoçi, Arben
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- 2023
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148. Riqueza de mamíferos terrestres y amenazas para su conservación en la Reserva Juan Bautista Alberdi, Oro Verde, Entre Ríos, Argentina.
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Morguenstern, Quione I., Maroli, Malena, Pineda Sánchez, Abigail, Zapata, Cintia V., Sanchez, Laura C., Prieto, Yanina A., Tarquini, Juliana, Hergenreder, Cristian, Grimaux, Alfredo, and Ronchi Virgolini, Ana L.
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NATURE reserves - Abstract
Copyright of Acta Zoologica Lilloana is the property of Fundacion Miguel Lillo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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149. Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling
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Nayakanti, Sreenath Reddy, primary, Friedrich, Aleksandra, additional, Sarode, Poonam, additional, Jafari, Leili, additional, Maroli, Giovanni, additional, Boehm, Mario, additional, Bourgeois, Alice, additional, Grobs, Yann, additional, Khassafi, Fatemeh, additional, Kuenne, Carsten, additional, Guenther, Stefan, additional, Dabral, Swati, additional, Wilhelm, Jochen, additional, Weiss, Astrid, additional, Wietelmann, Astrid, additional, Kojonazarov, Baktybek, additional, Janssen, Wiebke, additional, Looso, Mario, additional, de Man, Frances, additional, Provencher, Steeve, additional, Tello, Khodr, additional, Seeger, Werner, additional, Bonnet, Sebastien, additional, Savai, Rajkumar, additional, Schermuly, Ralph T., additional, and Pullamsett, Soni Savai, additional
- Published
- 2023
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150. Printed electronics: a low-cost alternative to prototyping in the academic field
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Maroli, Gabriel, primary, Aymonino, Oscar Andrés, additional, Oliva, Alejandro, additional, Gak, Joel, additional, Julián, Pedro, additional, and Palumbo, Félix, additional
- Published
- 2023
- Full Text
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