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112 results on '"Maria Pia Adorni"'

101. [43] STIMULATION OF ABCG1 CHOLESTEROL EFFLUX BY LXR-RXR AGONISTS IN HUMAN TANGIER FIBROBLASTS

Author

S. Costa, Maria Pia Adorni, Franco Bernini, L. Bocchi, V. Covati, Elda Favari, Tommaso Fasano, and Sebastiano Calandra

Subjects
medicine.medical_specialty, Nutrition and Dietetics, biology, Chemistry, Cholesterol, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Stimulation, Retinoid X receptor, chemistry.chemical_compound, Endocrinology, ABCG1, Internal medicine, biology.protein, medicine, Efflux, Cardiology and Cardiovascular Medicine, Liver X receptor
Published
2009

106. 56 A NOVEL HOMOZYGOUS MUTATION IN CETP GENE AS A CAUSE OF CETP DEFICIENCY IN A CAUCASIAN KINDRED

Author

Patrizia Tarugi, Peter M. Nilsson, Laura Calabresi, Cesare R. Sirtori, Elisa Pinotti, Franco Bernini, Guido Franceschini, Maria Pia Adorni, Elda Favari, Sebastiano Calandra, and Monica Gomaraschi

Subjects
Genetics, Nutrition and Dietetics, CETP DEFICIENCY, Endocrinology, Diabetes and Metabolism, Mutation (genetic algorithm), Medicine (miscellaneous), Biology, Cardiology and Cardiovascular Medicine, Gene
Published
2008

108. 1.4 Manidipine Inhibits the Release of Interleukin-6 (Il-6) Induced by Modified Lipoprotein and by TNF-Alpha in Culture Human Endothelial Cells

Author

Franco Bernini, S. Costa, Giovanni Cremonesi, Matteo Pedrelli, Maria Pia Adorni, and N. Ronda

Subjects
biology, business.industry, Pharmacology, Umbilical vein, Endothelial stem cell, Manidipine, Pharmacotherapy, Internal Medicine, medicine, biology.protein, Tumor necrosis factor alpha, Cardiology and Cardiovascular Medicine, business, Interleukin 6, Lipoprotein, medicine.drug
Published
2008

109. Th-P15:142 Cholesterol efflux from oxidized LDL loaded macrophages

Author

F. Bernini, F. Zimetti, Maria Pia Adorni, I. Zanotti, M. Canavesi, E. Favari, and A.E. Bortnick

Subjects
chemistry.chemical_compound, medicine.medical_specialty, Endocrinology, chemistry, Cholesterol, Internal medicine, Internal Medicine, medicine, General Medicine, Efflux, Cardiology and Cardiovascular Medicine, Oxidized ldl
Published
2006

111. Impaired ATP-binding cassette transporter A1-mediated sterol efflux from oxidized LDL-loaded macrophages

Author

Francesca Zimetti, Maria Pia Adorni, Franco Bernini, Anna E. Bortnick, Elda Favari, Ilaria Zanotti, and M. Canavesi

Subjects
Biophysics, Biochemistry, Cell Line, chemistry.chemical_compound, Mice, Oxidized low density lipoprotein, Downregulation and upregulation, Atherosclerosis, ATP-binding cassette A1, Cholesterol efflux, Foam cells, Macrophages, Structural Biology, Genetics, polycyclic compounds, Animals, Humans, Molecular Biology, Phospholipids, biology, Apolipoprotein A-I, Cholesterol, hemic and immune systems, Cell Biology, Sterol, Lipoproteins, LDL, Sterols, ATP Binding Cassette Transporter 1, chemistry, Low-density lipoprotein, ABCA1, Cholesteryl ester, biology.protein, ATP-Binding Cassette Transporters, lipids (amino acids, peptides, and proteins), Efflux
Abstract

We investigated the interaction of oxidized low density lipoprotein (OxLDL) with the ATP-binding cassette A1 (ABCA1) pathway in J774 macrophages. Cellular efflux to apolipoprotein AI (apo-AI) of OxLDL-derived cholesterol was lower than efflux of cholesterol derived from acetylated low density lipoprotein (AcLDL). ABCA1 upregulation by 8-(4-chlorophenylthio)adenosine 3′:5′-cyclic monophosphate (cpt-cAMP) or 22 (R)-hydroxycholesterol (22-OH) and 9-cis retinoic acid (9cRA) increased the efflux to apo-AI of cellular sterols derived from AcLDL, but not of those from OxLDL. AcLDL, but not OxLDL, induced ABCA1 protein content and activity in J774. However, OxLDL did not influence J774 ABCA1 upregulation by cpt-cAMP or 22-OH/9cRA. We conclude that sterols released to cells by OxLDL are available neither as substrate nor as modulator of ABCA1.

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112. EVALUATION OF SERUM CHOLESTEROL EFFLUX CAPACITY IN DIABETIC COMPARED TO HEALTHY SUBJECTS

Author

Elda Favari, Arrigo Fg Cicero, L. Franzini, Matteo Manfredini, Franco Bernini, Nicoletta Ronda, Maria Pia Adorni, Francesca Zimetti, Diego Ardigò, G.B. Vigna, Ivana Zavaroni, and Sebastiano Calandra

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Healthy subjects, Medicine, Efflux, Cardiology and Cardiovascular Medicine, business, Serum cholesterol

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