101. Relation between thoracic aortic inflammation and features of plaque vulnerability in the coronary tree in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention. An FDG-positron emission tomography and optical coherence tomography study
- Author
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Francesco Prati, Nevio Taglieri, Stefano Fanti, Rachele Bonfiglioli, Maria Letizia Bacchi Reggiani, Giacomo Maria Lima, Gabriele Ghetti, Francesco Saia, Cristina Nanni, Claudio Rapezzi, Valeria Marco, Taglieri, Nevio, Nanni, Cristina, Ghetti, Gabriele, Bonfiglioli, Rachele, Saia, Francesco, Bacchi Reggiani, Maria Letizia, Lima, Giacomo Maria, Marco, Valeria, Prati, Francesco, Fanti, Stefano, and Rapezzi, Claudio
- Subjects
Adult ,Male ,medicine.medical_specialty ,Acute coronary syndrome ,Radiology, Nuclear Medicine and Imaging ,18F-fluorodeoxyglucose-positron emission tomography ,Frequency domain-optical coherence tomography ,Non ST-segment elevation acute coronary syndrome ,Radiology ,Nuclear Medicine and Imaging ,medicine.medical_treatment ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,FDG-Positron Emission Tomography ,Coronary Angiography ,030218 nuclear medicine & medical imaging ,NO ,03 medical and health sciences ,0302 clinical medicine ,Percutaneous Coronary Intervention ,Fluorodeoxyglucose F18 ,Internal medicine ,medicine.artery ,medicine ,ST segment ,Thoracic aorta ,Humans ,Acute Coronary Syndrome ,Aorta ,medicine.diagnostic_test ,business.industry ,Percutaneous coronary intervention ,General Medicine ,Middle Aged ,medicine.disease ,Plaque, Atherosclerotic ,Positron emission tomography ,Descending aorta ,Positron-Emission Tomography ,Cardiology ,Female ,Radiopharmaceuticals ,business ,18Fâfluorodeoxyglucose-positron emission tomography ,Tomography, Optical Coherence - Abstract
Purpose: To evaluate the relationship between aortic inflammation as assessed by18Fâfluorodeoxyglucose-positron emission tomography (18FâFDG-PET) and features of plaque vulnerability as assessed by frequency domain-optical coherence tomography (FD-OCT). Methods: We enrolled 30 consecutive non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention. All patients underwent three-vessel OCT before intervention and18FâFDG-PET before discharge. Univariable and C-reactive protein (CRP)-adjusted linear regression analyses were performed between features of vulnerability [namely:lipid-rich plaques with and without macrophages and thin cap fibroatheromas (TCFA)] and18FâFDG uptake in both ascending (AA) and descending aorta (DA) [measured either as averaged mean and maximum target-to-blood ratio (TBR) or as active slices (TBRmax â¥Â 1.6)]. Results: Mean age was 62 years, and 26 patients were male. On univariable linear regression analysis TBRmeanand TBRmaxin DA was associated with the number of lipid-rich plaques (β = 4.22; 95%CI 0.05â8.39; p = 0.047 and β = 3.72; 95%CI 1.14â6.30; p = 0.006, respectively). TBRmaxin DA was also associated with the number of lipid-rich plaques containing macrophages (β = 2.40; 95%CI 0.07â4.72; p = 0.044). A significant CRP adjusted linear association between the TBRmaxin DA and the number of lipid-rich plaques was observed (CRP-adjusted β = 3.58; 95%CI -0.91-6.25; p = 0.01). TBRmaxin DA showed a trend towards significant CRP-adjusted association with number of lipid-rich plaques with macrophages (CRP-adjusted β = 2.30; 95%CI -0.11-4.71; p = 0.06). We also observed a CRP-adjusted (β = 2.34; 95%CI 0.22â4.47; p = 0.031) linear association between the number of active slices in DA and the number of lipid-rich plaques. No relation was found between FDG uptake in the aorta and the number of TCFAs. Conclusions: In patients with first NSTEACS, 18FâFDG uptake in DA is correlated with the number of OCT detected lipid-rich plaques with or without macrophages. This association may be independent from CRP values.
- Published
- 2017