154 results on '"Maria Ban"'
Search Results
102. A genome screen for linkage in Australian sibling-pairs with multiple sclerosis
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R Simmons, Melanie Maranian, Robert Heard, Graeme J. Stewart, Bruce Bennetts, Stephen Sawcer, Maria Ban, and Alastair Compston
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Linkage (software) ,Genetics ,Multiple Sclerosis ,Genetic Linkage ,Genome, Human ,Multiple sclerosis ,Siblings ,Immunology ,Australia ,Chromosome Mapping ,Disease ,Biology ,medicine.disease ,Genome ,Gene Frequency ,Genetic linkage ,medicine ,Genetic predisposition ,Microsatellite ,Humans ,Sibling ,Genetics (clinical) ,Microsatellite Repeats - Abstract
The role of genetic factors in determining susceptibility to multiple sclerosis is well established but, despite the global distribution of the disease, systematic efforts to locate susceptibility genes have concentrated exclusively on populations from the Northern Hemisphere. We performed a genome wide screen of linkage in the Australian population using a panel of 397 microsatellite markers in 54 affected sibling-pairs. Multipoint linkage analysis revealed four regions of suggestive linkage (on chromosomes 2p13, 4q26-28, 6q26 and Xp11) and 18 additional regions of potential linkage (at 1q43-44, 3q13-24, 4q24, 4q31-34, 5q11-13, 6q27, 7q33-35, 8p23-21, 9q21, 13q31-32, 16p13, 16p11, 16q23-24, 17p13, 18p11, 20p12-11, Xp21-11 and Xq23-28). Our results contribute to the available data adding new provisional regions of linkage as well as increasing support for areas previously implicated in genetic susceptibility to multiple sclerosis.
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- 2002
103. Report: Effects of Early-Life Psychosocial Adversities on Adolescent Grey Matter
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Nicholas Walsh, Tim Dalgleish, Michael Lombardo, Valerie Dunn, Anne-Laura Van Harmelen, Maria Ban, and Ian Goodyer
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- 2014
104. Fostering students’ emotion regulation during learning: Design and effects of a computer-based video training
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Petra Engelmann and Maria Bannert
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emotion regulation ,training ,cognitive reappraisal ,control-value-theory ,computer-based learning ,Special aspects of education ,LC8-6691 - Abstract
Emotions have an essential impact on students’ learning outcome. Empirical findings show negative correlations between negative emotions and learning outcome. Negative emotions during learning are quite common and become more frequent over the course of an academic career. Thus, regulating these emotions is important. Existing studies indicate that university students lack the ability to successfully regulate their emotions during learning. However, interventions to foster university students’ inherent emotion regulation during learning are missing. In an attempt to identify interventions, this study investigates the effect of a video-based emotion regulation training for university students on emotion regulation strategies, emotions, and learning outcome. One hundred and sixteen university students either received training in emotion regulation (n = 60) or in workplace design (n = 56) before learning in a computer-based learning environment about probability theory. The emotion regulation training lead to improved emotion regulation (more cognitive reappraisal, less suppression) and less frustration and anxiety, but did not affect learning outcome. The results confirm that university students experience significant emotion regulation difficulties and suggest that they need intensive training in emotional regulation.
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- 2019
105. Temporal Assessment of Self-Regulated Learning by Mining Students’ Think-Aloud Protocols
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Lyn Lim, Maria Bannert, Joep van der Graaf, Inge Molenaar, Yizhou Fan, Jonathan Kilgour, Johanna Moore, and Dragan Gašević
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self-regulated learning ,temporal patterns in SRL ,process mining ,fuzzy miner ,think aloud ,Psychology ,BF1-990 - Abstract
It has been widely theorized and empirically proven that self-regulated learning (SRL) is related to more desired learning outcomes, e.g., higher performance in transfer tests. Research has shifted to understanding the role of SRL during learning, such as the strategies and learning activities, learners employ and engage in the different SRL phases, which contribute to learning achievement. From a methodological perspective, measuring SRL using think-aloud data has been shown to be more insightful than self-report surveys as it helps better in determining the link between SRL activities and learning achievements. Educational process mining on the basis of think-aloud data enables a deeper understanding and more fine-grained analyses of SRL processes. Although students’ SRL is highly contextualized, there are consistent findings of the link between SRL activities and learning outcomes pointing to some consistency of the processes that support learning. However, past studies have utilized differing approaches which make generalization of findings between studies investigating the unfolding of SRL processes during learning a challenge. In the present study with 29 university students, we measured SRL via concurrent think-aloud protocols in a pre-post design using a similar approach from a previous study in an online learning environment during a 45-min learning session, where students learned about three topics and wrote an essay. Results revealed significant learning gain and replication of links between SRL activities and transfer performance, similar to past research. Additionally, temporal structures of successful and less successful students indicated meaningful differences associated with both theoretical assumptions and past research findings. In conclusion, extending prior research by exploring SRL patterns in an online learning setting provides insights to the replicability of previous findings from online learning settings and new findings show that it is important not only to focus on the repertoire of SRL strategies but also on how and when they are used.
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- 2021
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106. Cis acting expression loci in multiple sclerosis
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Stephen Sawcer, Mel Maranian, Alastair Compston, Tai Wai Yeo, Julia Gray, and Maria Ban
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Genetics ,Multiple Sclerosis ,Multiple sclerosis ,Immunology ,Biology ,medicine.disease ,Cis acting ,Gene Expression Regulation ,Neurology ,Expression (architecture) ,Genes, Regulator ,Expression quantitative trait loci ,medicine ,Humans ,Immunology and Allergy ,Neurology (clinical) - Published
- 2005
107. Two Interventions to Improve Knowledge of Scientific and Dissemination Articles in First-Year University Students
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Candela Zorzo, Cristina Fernández-Baizán, Alba Gutiérrez-Menéndez, María Banqueri, Sara G Higarza, and Marta Méndez
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scientific sources ,dissemination ,Pubmed ,neuroscience ,university students ,Psychology ,BF1-990 - Abstract
The representations of science in mass media have shown a significant increase in the last years. However, mass media dissemination activities can extend to pseudoscience due to the fact that not all scientific news are published with the same rigour. Thus, we aimed to develop two theoretical-practical interventions among first-year university students with the purpose of improving their knowledge about scientific studies and original scientific sources, as well as to critically analyze dissemination of scientific research in media. The interventions had a positive impact on knowledge about scientific information sources, particularly Pubmed, in addition to reducing the number of incorrect features linked to both scientific and dissemination articles, suggesting the importance of interventions focused on misconceptions. However, students showed knowledge of correct features of scientific articles, independently of our intervention, and they made more mistakes when attributing incorrect features to scientific articles when compared to dissemination ones.
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- 2021
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108. PATU11 IL2RA and CD226 genotypes influence multiple sclerosis disease outcome
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Richard C. Strange, R Abraham, Amie Baker, Clive Hawkins, T Mihalova, and Maria Ban
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Genetics ,education.field_of_study ,Genetic heterogeneity ,CD226 ,Multiple sclerosis ,Population ,Single-nucleotide polymorphism ,Biology ,medicine.disease ,Psychiatry and Mental health ,Polymorphism (computer science) ,Genotype ,medicine ,SNP ,Surgery ,Neurology (clinical) ,education - Abstract
Introduction MS is a chronic inflammatory disorder of the central nervous system. Whole genome analysis has identified discrete chromosomal regions outside the most powerfully associated MHC region that might harbour susceptibility genes: IL2RA , IL7R , TYK2 , CD226 and CLEC16. 1–4 Genetic heterogeneity is likely to contribute to variability in MS outcome. Methods We examined nine single nucleotide polymorphisms (SNPs) in eight genes in 742 MS with MS severity score being used as the disease outcome using linear regression statistical analysis (STATA). Results Mutant allele (GG) of SNP rs2104286, in gene IL2RA on chromosome 10p15, was associated with better disease outcome: p=0.004, coefficient=−1.23, 95% CI −2.1 to −0.4. Wild type allele (CC) of SNP rs763361, in gene CD226 on chromosome 18q22.3, was associated with better disease outcome: p=0.002, coefficient=−0.86, 95% CI −1.4 to −0.33. We detected no significant impact on disease outcome for the remaining 7 SNPs. Discussion We have demonstrated that polymorphism in IL2RA and CD226 genes appears to have significant influence on the disease outcome in our MS population. As novel therapies become more widely available for treatment of MS, risk assessment and response to therapy could soon be influenced by detailed genotype analysis in individual patients.
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- 2010
109. Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study
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Chiara Fallerini, Sergio Daga, Stefania Mantovani, Elisa Benetti, Nicola Picchiotti, Daniela Francisci, Francesco Paciosi, Elisabetta Schiaroli, Margherita Baldassarri, Francesca Fava, Maria Palmieri, Serena Ludovisi, Francesco Castelli, Eugenia Quiros-Roldan, Massimo Vaghi, Stefano Rusconi, Matteo Siano, Maria Bandini, Ottavia Spiga, Katia Capitani, Simone Furini, Francesca Mari, GEN-COVID Multicenter Study, Alessandra Renieri, Mario U Mondelli, and Elisa Frullanti
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TLR7 ,COVID-19 ,LASSO Logistic Regression Analysis ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Background: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. Methods: This is a nested case-control study in which we compared male participants with extreme phenotype selected from the Italian GEN-COVID cohort of SARS-CoV-2-infected participants (
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- 2021
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110. Advanced Access scheduling in general practice and use of primary care: a Danish population-based matched cohort study
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Maria Bang, Henrik Schou Pedersen, Bodil Hammer Bech, Claus Høstrup Vestergaard, Jannik Falhof, Hans Christian Kjeldsen, Peter Vedsted, and Mogens Vestergaard
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primary health care ,general practice ,after-hours care ,health services accessibility ,denmark ,Medicine (General) ,R5-920 - Abstract
Background: Advanced access scheduling (AAS) allows patients to receive care from their GP at the time chosen by the patient. AAS has shown to increase the accessibility to general practice, but little is known about how AAS implementation affects the use of in-hours and out-of-hours (OOH) services. Aim: To describe the impact of AAS on the use of in-hours and OOH services in primary care. Design & setting: A population-based matched cohort study using Danish register data. Method: A total of 161 901 patients listed in 33 general practices with AAS were matched with 287 837 reference patients listed in 66 reference practices without AAS. Outcomes of interest were use of daytime face-to-face consultations, and use of OOH face-to-face and phone consultations in a 2-year period preceding and following AAS implementation. Results: No significant differences were seen between AAS practices and reference practices. During the year following AAS implementation, the number of daytime face-to-face consultations was 3% (adjusted incidence rate ratio [aIRR] = 1.03; 95% confidence interval [CI] = 0.99 to 1.07) higher in the AAS practices compared with the number in the reference practices. Patients listed with an AAS practice had 2% (aIRR = 0.98; 95% CI = 0.92 to 1.04) fewer OOH phone consultations and 6% (aIRR = 0.94; 95% CI = 0.86 to 1.02) fewer OOH face-to-face consultations compared with patients listed with a reference practice. Conclusion: This study showed no significant differences following AAS implementation. However, a trend was seen towards slightly higher use of daytime primary care and lower use of OOH primary care.
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- 2020
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111. Symptomatic COVID-19 in advanced-cancer patients treated with immune-checkpoint inhibitors: prospective analysis from a multicentre observational trial by FICOG
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Melissa Bersanelli, Diana Giannarelli, Ugo De Giorgi, Sandro Pignata, Massimo Di Maio, Elena Verzoni, Alberto Clemente, Valentina Guadalupi, Diego Signorelli, Marcello Tiseo, Raffaele Giusti, Marco Filetti, Marilena Di Napoli, Lorenzo Calvetti, Alessandro Cappetta, Paola Ermacora, Diego Zara, Fausto Barbieri, Cinzia Baldessari, Vieri Scotti, Francesca Mazzoni, Antonello Veccia, Pamela Francesca Guglielmini, Marco Maruzzo, Ernesto Rossi, Francesco Grossi, Chiara Casadei, Alessio Cortellini, Francesco Verderame, Vincenzo Montesarchio, Mimma Rizzo, Manlio Mencoboni, Fable Zustovich, Lucia Fratino, Saverio Cinieri, Giorgia Negrini, Maria Banzi, Mariella Sorarù, Paolo Andrea Zucali, Gaetano Lacidogna, Antonio Russo, Nicola Battelli, Giuseppe Fornarini, Claudia Mucciarini, Sergio Bracarda, Andrea Bonetti, Debora Pezzuolo, Lucia Longo, Donata Sartori, Mauro Iannopollo, Luigi Cavanna, Fausto Meriggi, Davide Tassinari, Claudia Corbo, Angela Gernone, Veronica Prati, Simona Carnio, Pasqualina Giordano, Angela Maria Dicorato, Claudio Verusio, Francesco Atzori, Francesco Carrozza, Stefania Gori, Antonino Castro, Sara Pilotto, Vanja Vaccaro, Elisabetta Garzoli, Francesco Di Costanzo, Evaristo Maiello, Roberto Labianca, Carmine Pinto, Michele Tognetto, and Sebastiano Buti
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: This prospective, multicentre, observational INVIDIa-2 study is investigating the clinical efficacy of influenza vaccination in advanced-cancer patients receiving immune-checkpoint inhibitors (ICIs), enrolled in 82 Italian centres, from October 2019 to January 2020. The primary endpoint was the incidence of influenza-like illness (ILI) until 30 April 2020. All the ILI episodes, laboratory tests, complications, hospitalizations and pneumonitis were recorded. Therefore, the study prospectively recorded all the COVID-19 ILI events. Patients and methods: Patients were included in this non-prespecified COVID-19 analysis, if alive on 31 January 2020, when the Italian government declared the national emergency. The prevalence of confirmed COVID-19 cases was detected as ILI episode with laboratory confirmation of SARS-CoV-2. Cases with clinical-radiological diagnosis of COVID-19 (COVID-like ILIs), were also reported. Results: Out of 1257 enrolled patients, 955 matched the inclusion criteria for this unplanned analysis. From 31 January to 30 April 2020, 66 patients had ILI: 9 of 955 cases were confirmed COVID-19 ILIs, with prevalence of 0.9% [95% confidence interval (CI): 0.3–2.4], a hospitalization rate of 100% and a mortality rate of 77.8%. Including 5 COVID-like ILIs, the overall COVID-19 prevalence was 1.5% (95% CI: 0.5–3.1), with 100% hospitalization and 64% mortality. The presence of elderly, males and comorbidities was significantly higher among patients vaccinated against influenza versus unvaccinated ( p = 0.009, p
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- 2020
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112. Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions
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Maria Bantounou, Josip Plascevic, and Helen F. Galley
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n/a ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Melatonin, an indoleamine derived from tryptophan and produced in the pineal gland and other tissues [...]
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- 2022
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113. Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern
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Gemma Garcia-Vicién, Artur Mezheyeuski, Patrick Micke, Núria Ruiz, José Carlos Ruffinelli, Kristel Mils, María Bañuls, Natàlia Molina, Ferran Losa, Laura Lladó, and David G. Molleví
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liver metastases ,lymphocyte ,immunology ,desmoplasia ,growth pattern ,multiplex ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Colorectal cancer liver metastases (CRC-LM) present differential histologic growth patterns (HGP) that determine the interaction between immune and tumor cells. We explored the spatial distribution of lymphocytic infiltrates in CRC-LM in the context of the HGP using multispectral digital pathology. We did not find statistically significant differences of immune cell densities in the central regions of desmoplastic (dHGP) and non-desmoplastic (ndHGP) metastases. The spatial evaluation reported that dHGP-metastases displayed higher infiltration by CD8+ and CD20+ cells in peripheral regions as well as CD4+ and CD45RO+ cells in ndHGP-metastases. However, the reactive stroma regions at the invasive margin (IM) of ndHGP-metastases displayed higher density of CD4+, CD20+, and CD45RO+ cells. The antitumor status of the TIL infiltrates measured as CD8/CD4 reported higher values in the IM of encapsulated metastases up to 400 μm towards the tumor center (p < 0.05). Remarkably, the IM of dHGP-metastases was characterized by higher infiltration of CD8+ cells in the epithelial compartment parameter assessed with the ratio CD8epithelial/CD8stromal, suggesting anti-tumoral activity in the encapsulating lesions. Taking together, the amount of CD8+ cells is comparable in the IM of both HGP metastases types. However, in dHGP-metastases some cytotoxic cells reach the tumor nests while remaining retained in the stromal areas in ndHGP-metastases.
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- 2022
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114. Mitochondrial Toxicogenomics for Antiretroviral Management: HIV Post-exposure Prophylaxis in Uninfected Patients
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Maria Bañó, Constanza Morén, Sergio Barroso, Diana Luz Juárez, Mariona Guitart-Mampel, Ingrid González-Casacuberta, Judith Canto-Santos, Ester Lozano, Agathe León, Enric Pedrol, Òscar Miró, Ester Tobías, Josep Mallolas, Jhon F. Rojas, Francesc Cardellach, Esteban Martínez, and Gloria Garrabou
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ART ,HIV ,mitochondria ,mtDNA ,PEP ,Genetics ,QH426-470 - Abstract
Background: Mitochondrial genome has been used across multiple fields in research, diagnosis, and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA), including biological and therapeutic agents like the human immunodeficiency virus (HIV) but also its antiretroviral treatment, leading to adverse clinical manifestations. HIV-infected and treated patients may show impaired mitochondrial and metabolic profile, but specific contribution of viral or treatment toxicity remains elusive. The evaluation of HIV consequences without treatment interference has been performed in naïve (non-treated) patients, but assessment of treatment toxicity without viral interference is usually restricted to in vitro assays.Objective: The objective of the present study is to determine whether antiretroviral treatment without HIV interference can lead to mtDNA disturbances. We studied clinical, mitochondrial, and metabolic toxicity in non-infected healthy patients who received HIV post-exposure prophylaxis (PEP) to prevent further infection. We assessed two different PEP regimens according to their composition to ascertain if they were the cause of tolerability issues and derived toxicity.Methods: We analyzed reasons for PEP discontinuation and main secondary effects of treatment withdrawal, mtDNA content from peripheral blood mononuclear cells and metabolic profile, before and after 28 days of PEP, in 23 patients classified depending on PEP composition: one protease inhibitor (PI) plus Zidovudine/Lamivudine (PI plus AZT + 3TC; n = 9) or PI plus Tenofovir/Emtricitabine (PI plus TDF + FTC; n = 14).Results: Zidovudine-containing-regimens showed an increased risk for drug discontinuation (RR = 9.33; 95% CI = 1.34–65.23) due to adverse effects of medication related to gastrointestinal complications. In the absence of metabolic disturbances, 4-week PEP containing PI plus AZT + 3TC led to higher mitochondrial toxicity (−17.9 ± 25.8 decrease in mtDNA/nDNA levels) than PI plus TDF + FTC (which increased by 43.2 ± 24.3 units mtDNA/nDNA; p < 0.05 between groups). MtDNA changes showed a significant and negative correlation with baseline alanine transaminase levels (p < 0.05), suggesting that a proper hepatic function may protect from antiretroviral toxicity.Conclusions: In absence of HIV infection, preventive short antiretroviral treatment can cause secondary effects responsible for treatment discontinuation and subclinical mitochondrial damage, especially pyrimidine analogs such as AZT, which still rank as the alternative option and first choice in certain cohorts for PEP. Forthcoming efforts should be focused on launching new strategies with safer clinical and mitotoxic profile.
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- 2020
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115. Perfusion Computed Tomography Scan Imaging in Differentiation of Benign from Malignant Parotid Lesions
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Masume Niazi, Maryam Mohammadzadeh, Kayvan Aghazadeh, Hashem Sharifian, Ebrahim Karimi, Madjid Shakiba, Maria Baniasadi, Benyamin Rahmaty, Suzan Adel, and Melorina Moharreri
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computed tomography ,magnetic resonance imaging ,parotid neoplasms ,warthin's tumor ,pleomorphic adenoma ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
Introduction The most common site of salivary gland tumors is the parotid gland. Computed tomography (CT), magnetic resonance imaging (MRI), and sonography are imaging modalities to differentiate benign from malignant parotid tumors. Objective The aim of this study is the evaluation of the diagnostic value of perfusion CT for differentiating histological categorization of benign and malignant parotid tumors. Methods A total of 29 patients with parotid neoplasms were enrolled in this study. Mean age and all CT perfusion variables (gradient and permeability, blood flow [BF], blood volume [BV], mean transit time [MTT], permeability surface [PS], maximum intensity projection [MIP], time-density curve [TDC], and time to peak [TTP]) were compared among three groups (malignant tumors [MTs], Warthin's tumor [WT] and pleomorphic adenomas [PA]). Results The mean age of the patients was 55.9 ± 14.1 (26–77), and 15 of them were male (51.7%). Eleven lesions were PAs [37.9%], 8 lesions were WTs (27.6%0 and 10 lesions (34.5%) were MTs (6 acinic cell carcinomas [ACCs], 3 adenocystic carcinomas [AdCCs], and 1 mucoepidermoid carcinoma [MEC]). The mean age of the patients with WTs was 62 ± 7.5 years; 52 ± 14.2 for patients with Pas, and 55.2 ± 17.2 for those with MTs (p = 0.32). The mean MIP was 122.7 ± 12.2 in WT, while it was 80.5 ± 19.5 in PA, and 76.2 ± 27.1 in MTs (p
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- 2020
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116. Khorana score and thromboembolic risk in stage II–III colorectal cancer patients: a analysis from the adjuvant TOSCA trial
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Sandro Barni, Gerardo Rosati, Sara Lonardi, Nicoletta Pella, Maria Banzi, Maria G. Zampino, Katia F. Dotti, Lorenza Rimassa, Paolo Marchetti, Evaristo Maiello, Fabrizio Artioli, Daris Ferrari, Roberto Labianca, Paolo Bidoli, Alberto Zaniboni, Alberto Sobrero, Vincenzo Iaffaioli, Sabino De Placido, Gian Luca Frassineti, Andrea Ciarlo, Angela Buonadonna, Nicola Silvestris, Elena Piazza, Lorenzo Pavesi, Mauro Moroni, Mario Clerico, Massimo Aglietta, Paolo Giordani, Francesca Galli, Fabio Galli, and Fausto Petrelli
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: The risk of venous thromboembolic events (VTE) during adjuvant chemotherapy for colorectal cancer (CRC) is unknown. We aim to evaluate if the Khorana score (KS) can predict this risk, and if it represents a prognostic factor for overall survival (OS) through a post hoc analysis of the phase III TOSCA trial of different durations (3- versus 6-months) of adjuvant chemotherapy. Methods: A logistic regression model was used to test the associations between the risk of VTE and the KS. The results are expressed as odds ratios (OR) with 95% confidence intervals (95% CI). To assess the effect of the KS on OS, multivariable analyses using Cox regression models were performed. The results are expressed as hazard ratios (HR) with 95% CI. Results: Among 1380 CRC patients with available data, the VTE risk ( n = 72 events: 5.2%) was similar in the two duration arms (5.5% versus 4.9%), with 0.2% of patients belonging to the high-risk KS group. Rates of VTE were similar in the low- and intermediate-risk groups (4.8% versus 6.4%). KS did not represent an independent predictive factor for VTE occurrence. Chemotherapy duration was not associated with VTE risk. In addition, KS was not prognostic for OS in multivariate analysis (HR: 0.92, 95% CI, 0.63–1.36; p = 0.6835). Conclusions: The use of the KS did not predict VTEs in a low–moderate thromboembolic risk population as CRC. These data did not support the use of KS to predict VTE during adjuvant chemotherapy, and suggest that other risk assessment models should be researched.
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- 2020
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117. Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson’s disease
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Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén, and Glòria Garrabou
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Parkinson’s disease ,LRRK2 ,G2019S ,Non-manifesting carriers ,Mitochondrial dysfunction ,Mitochondrial dynamics ,Medicine - Abstract
Abstract Background Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed to study the role of mitochondria and autophagy in LRRK2 G2019S -mutation, and its relationship with the presence of PD-symptoms. Methods Fibroblasts from six non-manifesting LRRK2 G2019S -carriers (NM-LRRK2 G2019S ) and seven patients with LRRK2 G2019S -associated PD (PD-LRRK2 G2019S ) were compared to eight healthy controls (C). An exhaustive assessment of mitochondrial performance and autophagy was performed after 24-h exposure to standard (glucose) or mitochondrial-challenging environment (galactose), where mitochondrial and autophagy impairment may be heightened. Results A similar mitochondrial phenotype of NM-LRRK2 G2019S and controls, except for an early mitochondrial depolarization (54.14% increased, p = 0.04), was shown in glucose. In response to galactose, mitochondrial dynamics of NM-LRRK2 G2019S improved (− 17.54% circularity, p = 0.002 and + 42.53% form factor, p = 0.051), probably to maintain ATP levels over controls. A compromised bioenergetic function was suggested in PD-LRRK2 G2019S when compared to controls in glucose media. An inefficient response to galactose and worsened mitochondrial dynamics (− 37.7% mitochondrial elongation, p = 0.053) was shown, leading to increased oxidative stress. Autophagy initiation (SQTSM/P62) was upregulated in NM-LRRK2 G2019S when compared to controls (glucose + 118.4%, p = 0.014; galactose + 114.44%, p = 0.009,) and autophagosome formation increased in glucose media. Despite of elevated SQSTM1/P62 levels of PD-NM G2019S when compared to controls (glucose + 226.14%, p = 0.04; galactose + 78.5%, p = 0.02), autophagosome formation was deficient in PD-LRRK2 G2019S when compared to NM-LRRK2 G2019S (− 71.26%, p = 0.022). Conclusions Enhanced mitochondrial performance of NM-LRRK2 G2019S in mitochondrial-challenging conditions and upregulation of autophagy suggests that an exhaustion of mitochondrial bioenergetic and autophagic reserve, may contribute to the development of PD in LRRK2 G2019S mutation carriers.
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- 2018
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118. The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation
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Natalia Guillén Díaz-Maroto, Gemma Garcia-Vicién, Giovanna Polcaro, María Bañuls, Nerea Albert, Alberto Villanueva, and David G. Molleví
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interleukin 1 beta ,tumor microenvironment ,stroma ,resistance ,myofibroblasts ,inflammatory CAFs ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Heterotypic interactions between newly transformed cells and normal surrounding cells define tumor’s fate in incipient carcinomas. Once homeostasis has been lost, normal resident fibroblasts become carcinoma-associated fibroblasts, conferring protumorogenic properties on these normal cells. Here we describe the IL1β-mediated interplay between cancer cells and normal colonic myofibroblasts (NCFs), which bestows differential sensitivity to cytotoxic drugs on tumor cells. We used NCFs, their conditioned media (CM), and cocultures with tumor cells to characterize the IL1β-mediated crosstalk between both cell types. We silenced IL1β in tumor cells to demonstrate that such cells do not exert an influence on NCFs inflammatory phenotype. Our results shows that IL1β is overexpressed in cocultured tumor cells. IL1β enables paracrine signaling in myofibroblasts, converting them into inflammatory-CAFs (iCAF). IL1β-stimulated-NCF-CM induces migration and differential sensitivity to oxaliplatin in colorectal tumor cells. Such chemoprotective effect has not been evidenced for TGFβ1-driven NCFs. IL1β induces the loss of a myofibroblastic phenotype in NCFs and acquisition of iCAF traits. In conclusion, IL1β-secreted by cancer cells modify surrounding normal fibroblasts to confer protumorogenic features on them, particularly tolerance to cytotoxic drugs. The use of IL1β-blocking agents might help to avoid the iCAF traits acquisition and consequently to counteract the protumorogenic actions these cells.
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- 2021
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119. A second major histocompatibility complex susceptibility locus for multiple sclerosis.
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Tai Wai Yeo, Philip L. De Jager, Simon G. Gregory, Lisa F. Barcellos, Amie Walton, An Goris, Chiara Fenoglio, Maria Ban, Craig J. Taylor, Reyna S. Goodman, Emily Walsh, Cara S. Wolfish, Roger Horton, James Traherne, Stephan Beck, John Trowsdale, Stacy J. Caillier, Adrian J. Ivinson, Todd Green, and Susan Pobywajlo
- Abstract
Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLAâDRB1 gene in the class II region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed.Using a combination of microsatellite, single nucleotide polymorphism, and human leukocyte antigen (HLA) typing, we screened the MHC in trio families looking for evidence of residual association above and beyond that attributable to the established DRB1*1501 risk haplotype. We then refined this analysis by extending the genotyping of classical HLA loci into independent cases and control subjects.Screening confirmed the presence of residual association and suggested that this was maximal in the region of the HLAâC gene. Extending analysis of the classical loci confirmed that this residual association is partly due to allelic heterogeneity at the HLAâDRB1 locus, but also reflects an independent effect from the HLAâC gene. Specifically, the HLAâC*05 allele, or a variant in tight linkage disequilibrium with it, appears to exert a protective effect (p = 3.3 Ã 10â5).Variation in the HLAâC gene influences susceptibility to multiple sclerosis independently of any effect attributable to the nearby HLAâDRB1 gene. Ann Neurol 2007 [ABSTRACT FROM AUTHOR]
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- 2007
120. Effects of hybrid comprehensive cardiac telerehabilitation conducted under the pension prevention program of the Social Insurance Institution
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Ewa Piotrowicz, Piotr Orzechowski, Anna Jasionowska, Maria Banaszak-Bednarczyk, Monika Rosłaniec, Walerian Piotrowski, and Ryszard Piotrowicz
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telerehabilitation ,training ,telemonitoring ,pension prevention ,rehabilitation ,Nordic walking ,Public aspects of medicine ,RA1-1270 - Abstract
Background: The Polish Social Insurance Institution (SII), under its pension prevention initiative, has taken measures to support the patients return to work and thus developed a new model of hybrid, comprehensive, cardiac telerehabilitation (HCCT). The aim of the study was to analyze the effects of HCCT in terms of its acceptance, adherence to and influence on patients’ physical capacity and ability to return to work. Material and Methods: The study included 99 patients, aged 54.6±6.3 years, who suffered from cardiovascular diseases. They participated in a 24-day HCCT consisting of preliminary and final examinations, 10 days of out-patients rehabilitation based on cycloergometer training (5 sessions) and Nordic walking training (10 sessions), and 12 days of home telerehabilitation based on Nordic walking training. The effectiveness of HCCT was assessed by comparing changes in functional capacity expressed by metabolic equivalent of task (MET) and a 6-min walking test (6-MWT) distance from the beginning and the end of HCCT. Acceptance of HCCT was evaluated using a questionnaire. Adherence to HCCT was assessed by the patients’ participation in the training sessions. Effectiveness of HCCT in terms of return to work was assessed according to SII definition. Results: Hybrid, comprehensive, cardiac telerehabilitation resulted in significant improvement of functional capacity 7.6±2.0 vs. 8.1±2.4 MET (p < 0.0001) and distance in 6-MWT 448.5±79.2 m vs. 480.5±84.1 m (p < 0.0001). There were 82.8% of adherent, 16.2% of partially adherent and 1% of non-adherent patients. After HCCT 48 patients were able to return to work. Conclusions: Hybrid, comprehensive, cardiac telerehabilitation was well accepted and led to the improvement of the patients’ physical capacity. Adherence to HCCT was high and allowed 48.48% of patients return to work. Med Pr 2017;68(1):61–74
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- 2017
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121. Atypical Gianotti-Crosti syndrome
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Aline Pantano Marcassi, Christiane Affonso de Donato Piazza, Maria Bandeira de Melo Paiva Seize, and Silmara da Costa Pereira Cestari
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Acrodermatitis ,Epstein-Barr virus infections ,Skin diseases, Vesiculobullous ,Dermatology ,RL1-803 - Abstract
Abstract: We report the case of a male 22-month-old child, with atypical presentation of Gianotti-Crosti syndrome after infection with Epstein-Barr virus.
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- 2018
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122. Disfluency as a Desirable Difficulty—The Effects of Letter Deletion on Monitoring and Performance
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Elisabeth Pieger, Christoph Mengelkamp, and Maria Bannert
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metacomprehension ,disfluency ,metacognitive monitoring ,metacognitive control ,metacognitive judgments ,desirable difficulties ,Education (General) ,L7-991 - Abstract
Desirable difficulties initiate learning processes that foster performance. Such a desirable difficulty is generation, e.g., filling in deleted letters in a deleted letter text. Likewise, letter deletion is a manipulation of processing fluency: A deleted letter text is more difficult to process than an intact text. Disfluency theory also supposes that disfluency initiates analytic processes and thus, improves performance. However, performance is often not affected but, rather, monitoring is affected. The aim of this study is to propose a specification of the effects of disfluency as a desirable difficulty: We suppose that mentally filling in deleted letters activates analytic monitoring but not necessarily analytic cognitive processing and improved performance. Moreover, once activated, analytic monitoring should remain for succeeding fluent text. To test our assumptions, half of the students (n = 32) first learned with a disfluent (deleted letter) text and then with a fluent (intact) text. Results show no differences in monitoring between the disfluent and the fluent text. This supports our assumption that disfluency activates analytic monitoring that remains for succeeding fluent text. When the other half of the students (n = 33) first learned with a fluent and then with a disfluent text, differences in monitoring between the disfluent and the fluent text were found. Performance was significantly affected by fluency but in favor of the fluent texts, and hence, disfluency did not activate analytic cognitive processing. Thus, difficulties can foster analytic monitoring that remains for succeeding fluent text, but they do not necessarily improve performance. Further research is required to investigate how analytic monitoring can lead to improved cognitive processing and performance.
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- 2018
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123. The Tumor Microenvironment in Liver Metastases from Colorectal Carcinoma in the Context of the Histologic Growth Patterns
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Gemma Garcia-Vicién, Artur Mezheyeuski, María Bañuls, Núria Ruiz-Roig, and David G. Molleví
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histologic growth patterns ,desmoplasia ,carcinoma-associated fibroblasts ,microenvironment ,liver ,hepatic stellate cells ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Colorectal carcinoma (CRC) is the third most common cancer. Likewise, it is a disease that has a long survival if it is prematurely detected. However, more than 50% of patients will develop metastases, mainly in the liver (LM-CRC), throughout the evolution of their disease, which accounts for most CRC-related deaths. Treatment it is certainly a controversial issue, since it has not been shown to increase overall survival in the adjuvant setting, although it does improve disease free survival (DFS). Moreover, current chemotherapy combinations are administered based on data extrapolated from primary tumors (PT), not considering that LM-CRC present a very particular tumor microenvironment that can radically condition the effectiveness of treatments designed for a PT. The liver has a particular histology and microenvironment that can determine tumor growth and response to treatments: double blood supply, vascularization through fenestrated sinusoids and the presence of different mesenchymal cell types, among other particularities. Likewise, the liver presents a peculiar immune response against tumor cells, a fact that correlates with the poor response to immunotherapy. All these aspects will be addressed in this review, putting them in the context of the histological growth patterns of LM-CRC, a particular pathologic feature with both prognostic and predictive repercussions.
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- 2021
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124. Elastoma: clinical and histopathological aspects of a rare disease
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Marina Gagheggi Maciel, Milvia Maria Simões e Silva Enokihara, Maria Bandeira de Melo Paiva Seize, Aline Pantano Marcassi, Christiane Affonso De Donato Piazza, and Silmara da Costa Pereira Cestari
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Connective tissue diseases ,Elastic tissue ,Nevus ,Dermatology ,RL1-803 - Abstract
Abstract Elastoma is a connective tissue nevus characterized by changes in elastic fibers. It can be congenital or acquired, and is usually diagnosed before puberty. Associated with osteopoikilosis, it is known as Buschke-Ollendorff syndrome. Histopathology with specific staining for elastic fibers is critical for a diagnostic conclusion. This report describes the case of a 7-year-old male patient with lesions diagnosed as elastoma, with absence of bone changes in the radiological imaging. This study aims to report the clinical presentation and histological examination of such unusual disease.
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- 2016
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125. WHAT ARE EUROPEAN INVESTMENTS FOR THE RURAL DEVELOPMENT IN THE REPUBLIC OF MOLDOVA
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Ion CERTAN and Maria BANARI
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EU integration ,EU investments ,market economy ,rural area ,rural development ,Agriculture (General) ,S1-972 - Abstract
Since its independence Republic of Moldova takes great efforts to align with the big family of the European Union and in July 2014 it has made a huge step towards this by signing the Association Agreement and Free Trade Agreement with the EU. These impose our country to accelerate reforms and take all possible measures in order to reduce the gap of economic and socio-cultural development, adjusting it to the EU standards. One of the most sensible issues is the rural space conservation and further durable development that needs wide types of actions in almost all aspects. In the paper the authors consider what are EU investments for the rural development that will sum up with some conclusions and recommendations to be implemented in the Republic of Moldova.
- Published
- 2015
126. Nontuberculous mycobacteria pathogenesis and biofilm assembly
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Sara Sousa, Maria Bandeira, Patricia Almeida Carvalho, Aida Duarte, and Luisa Jordao
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Nontuberculous mycobacteria (NTM) ,Biofilms ,Scanning electron microscopy (SEM) ,Host–pathogen interaction ,Microbiology ,QR1-502 - Abstract
Nontuberculous mycobacteria (NTM) are emergent pathogens whose importance in human health has been gaining relevance after being recognized as etiological agents of opportunist infections in HIV patients. Currently, NTM are recognized as etiological agents of several respiratory and extra-respiratory infections of immune-competent individuals. The environmental nature of NTM together with the ability to assemble biofilms on different surfaces plays a key role on their pathogenesis. In the present work the ability of three fast-growing NTM (Mycobacterium smegmatis, Mycobacterium fortuitum and Mycobacterium chelonae) to persist within a model of human alveolar macrophages was evaluated. Most often human infections with NTM occur by contact with the environment. Biofilms can work as environmental reservoirs. For this reason, it was decided to evaluate the ability of NTM to assemble biofilms on different surfaces. Scanning electron microscopy was used to elucidate the biofilm structure. The ability to assemble biofilms was connected with the ability to spread on solid media known as sliding. Biofilm assembly and intracellular persistence seems to be ruled by different mechanisms.
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- 2015
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127. A High-Density Screen for Linkage in Multiple Sclerosis
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L P Ryder, A. Oturai, L. F. Barcellos, Maria Ban, Andrew Kirby, A Ivinson, Oksenberg, K. M. Myhr, M Laaksonen, Yeo Tw, Pameli Datta, Robin R. Lincoln, Jacqueline Rimmler, David A. Hafler, Stephen L. Hauser, David R. Booth, Stephen Sawcer, Eva Åkesson, Mark J. Daly, Robert Heard, Alastair Compston, Graeme J. Stewart, Eric S. Lander, Simon G. Gregory, Silke Schmidt, Hanne F. Harbo, Anne Spurkland, Shannon J. Kenealy, Emily Walsh, Jonathan L. Haines, Melanie Maranian, John D. Rioux, Margaret A. Pericak-Vance, Jan Hillert, and De Jager Pl
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Genetic Markers ,Multiple Sclerosis ,Genetic Linkage ,Locus (genetics) ,Biology ,Genome ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Genetic linkage ,Genetics ,Chromosomes, Human ,Humans ,Family ,Genetic Predisposition to Disease ,Genetic Testing ,Allele ,Genetics (clinical) ,030304 developmental biology ,0303 health sciences ,Australia ,Chromosome Mapping ,Articles ,Genomics ,Middle Aged ,United States ,Complete linkage ,Human genetics ,Europe ,Mendelian inheritance ,symbols ,Human genome ,030217 neurology & neurosurgery - Abstract
To provide a definitive linkage map for multiple sclerosis, we have genotyped the Illumina BeadArray linkage mapping panel (version 4) in a data set of 730 multiplex families of Northern European descent. After the application of stringent quality thresholds, data from 4,506 markers in 2,692 individuals were included in the analysis. Multipoint nonparametric linkage analysis revealed highly significant linkage in the major histocompatibility complex (MHC) on chromosome 6p21 (maximum LOD score [MLS] 11.66) and suggestive linkage on chromosomes 17q23 (MLS 2.45) and 5q33 (MLS 2.18). This set of markers achieved a mean information extraction of 79.3% across the genome, with a Mendelian inconsistency rate of only 0.002%. Stratification based on carriage of the multiple sclerosis-associated DRB1*1501 allele failed to identify any other region of linkage with genomewide significance. However, ordered-subset analysis suggested that there may be an additional locus on chromosome 19p13 that acts independent of the main MHC locus. These data illustrate the substantial increase in power that can be achieved with use of the latest tools emerging from the Human Genome Project and indicate that future attempts to systematically identify susceptibility genes for multiple sclerosis will have to involve large sample sizes and an association-based methodology.
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128. Effect of Bucillamine on Free-Radical-Mediated Degradation of High-Molar-Mass Hyaluronan Induced in vitro by Ascorbic Acid and Cu(II) Ions
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Mária Baňasová, Katarína Valachová, Jozef Rychlý, Ivica Janigová, Katarína Csomorová, Raniero Mendichi, Danica Mislovičová, Ivo Juránek, and Ladislav Šoltés
- Subjects
disease-modifying antirheumatic drugs ,rotational viscometry ,size exclusion chromatography ,thermo-analytical methods ,Organic chemistry ,QD241-441 - Abstract
The bucillamine effect on free-radical-mediated degradation of high-molar-mass hyaluronan (HA) has been elucidated. As HA fragmentation is expected to decrease its dynamic viscosity, rotational viscometry was applied to follow the oxidative HA degradation. Non-isothermal chemiluminometry, thermogravimetry, differential scanning calorimetry, and size-exclusion chromatography (SEC) were applied to characterize resulting HA fragments. Although bucillamine completely inhibited the HA viscosity decrease caused by oxidative system, indicating HA protection from degradation, SEC analysis suggested that some other mechanisms leading to the bucillamine transformations without the decay of the viscosity may come into a play as well. Nonetheless, the link between the reduction of chemiluminescence intensity and disappearance of the differential scanning calorimetry exotherm at 270 °C for fragmented HAs indicates a particular role of the bucillamine in preventing the decrease of HA viscosity.
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- 2014
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129. The oral microbiota of patients with recurrent aphthous stomatitis
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Maria Bankvall, Fei Sjöberg, Gita Gale, Agnes Wold, Mats Jontell, and Sofia Östman
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oral mucosa ,oral mucosal disease ,oral bacteria ,Terminal-Restriction Fragment Length Polymorphism ,oral ulceration ,oral cavity ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Background: Specific pathogenic bacteria have been implicated in recurrent aphthous stomatitis (RAS), a chronic inflammatory condition characterised by ulcerations in the oral mucosa. However, the aetiology behind this condition still remains unclear. Objective: The buccal microbiota of patients with RAS was compared to that of control subjects to investigate its potential role for this condition. Design: Buccal swabs were obtained from non-ulcerative areas of 60 patients, of whom 42 patients had lesions at the time of sampling, and 60 healthy age- and gender-matched controls. Bacterial DNA was extracted and analysed by Terminal-Restriction Fragment Length Polymorphism, using enzymatic digestion of the polymerase chain reaction-amplified 16S rRNA gene, yielding a series of peaks, each representing a bacterial taxon. Results: Two peaks, 60 and 489, were more prevalent in patients with RAS than controls. Conversely, peaks 58 and 490 were less common in patients than controls. When the patients were divided into subgroups, we found that the observed differences in peak-pattern were related to the presence of lesions during sampling. Conclusions: The microbiota of the non-inflamed buccal mucosa differed between patients and controls. The differences were most pronounced in patients who presented with lesions during sampling, suggesting that a disturbance in the normal buccal microbiota triggers the presence of lesions or that presence of lesions alters the microbiota.
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- 2014
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130. Principals Perceptions of their Knowledge in Special Education
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Maria Banda Roberts and Federico R Guerra
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Equity ,Special Education Leadership ,Principal Preparation ,Education - Abstract
With the Every Student Succeeds Act continuing to legislate accountability for special education and Hispanic students, the appropriate content in principal preparation programs relevant to successful leadership of special education programs is vital. This mixed methods study analyzed the survey responses of 84 principals in South Texas from predominantly Hispanic schools to determine the principals perceptions regarding their legal, foundational, and contextual knowledge of special education and their suggested topics for inclusion in curriculum content of principal preparation programs to provide the necessary knowledge and skills to effectively implement and supervise special education programs. Results indicated that the principals greatest knowledge was of the Individuals with Disabilities Education Act (100%) and the lowest area of knowledge was in designing curriculum for students with disabilities (65%). The most frequent recommendation for inclusion in principal preparation was for additional content in special education laws, Section 504, and Response to Intervention.
- Published
- 2017
131. Lingual microbiota profiles of patients with geographic tongue
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Amal Dafar, Maria Bankvall, Hülya Çevik-Aras, Mats Jontell, and Fei Sjöberg
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Benign migratory glossitis ,tongue lesions ,oral mucosal lesions ,oral diseases ,next-generation sequencing ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Geographic tongue (GT) is an oral mucosal lesion that affects the tongue. The association between GT and the bacterial colonization profiles of the tongue is not clear. Lingual swabs were collected from lesion sites and healthy sites of 35 patients with GT (19 males and 16 females; Mage = 54.3 ± 16.1 years) and 22 controls (12 males and 10 females; Mage = 56.3 ± 15.8 years). Bacterial DNA was extracted and sequenced by next-generation sequencing. At the phylum level, Fusobacteria were significantly less abundant, while Spirochaetes were significantly more abundant in GT patients compared to controls. At the operational taxonomic units level, multivariate analysis revealed distinct clusters for the three groups based on the lingual microbiota composition. Acinetobacter and Delftia were significantly associated with GT lesion and healthy sites. However, Microbacterium, Leptospira, Methylotenera, and Lactococcus were significantly associated with GT lesion sites. Additionally, Mogibacterium and Simonsiella were significantly associated with GT healthy sites and controls. The changes in the lingual microbiota profiles of patients with GT imply a shift in the lingual bacterial ecology. However, it remains unknown if this shift is a consequence of the lesions or of factors associated with the initiation and progression of the disease.
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- 2017
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132. The Better You Feel the Better You Learn: Do Warm Colours and Rounded Shapes Enhance Learning Outcome in Multimedia Learning?
- Author
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Hannes Münchow, Christoph Mengelkamp, and Maria Bannert
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Education (General) ,L7-991 - Abstract
The aim of the present study was to examine whether fostering positive activating affect during multimedia learning enhances learning outcome. University students were randomly assigned to either a multimedia learning environment designed to induce positive activating affect through the use of “warm” colours and rounded shapes (n=61) or an affectively neutral environment that used achromatic colours and sharp edges (n=50). Participants learned about the topic of functional neuroanatomy for 20 minutes and had to answer several questions for comprehension and transfer afterwards. Affective states as well as achievement goal orientations were investigated before and after the learning phase using questionnaires. The results show that participants in the affectively positive environment were superior in comprehension as well as transfer when initial affect was strong. Preexperimental positive affect was therefore a predictor of comprehension and a moderator for transfer. Goal orientations did not influence these effects. The findings support the idea that positive affect, induced through the design of the particular multimedia learning environment, can facilitate performance if initial affective states are taken into account.
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- 2017
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133. Exploring Dangerous Connections between Klebsiella pneumoniae Biofilms and Healthcare-Associated Infections
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Maria Bandeira, Patricia Almeida Carvalho, Aida Duarte, and Luisa Jordao
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biofilm ,healthcare-associated infections (HAI) ,antibiotic resistance ,scanning electron microscopy (SEM) ,Medicine - Abstract
Healthcare-associated infections (HAI) are a huge public health concern, particularly when the etiological agents are multidrug resistant. The ability of bacteria to develop biofilm is a helpful skill, both to persist within hospital units and to increase antibiotic resistance. Although the links between antibiotic resistance, biofilms assembly and HAI are consensual, little is known about biofilms. Here, electron microscopy was adopted as a tool to investigate biofilm structures associated with increased antibiotic resistance. The K. pneumoniae strains investigated are able to assemble biofilms, albeit with different kinetics. The biofilm structure and the relative area fractions of bacteria and extracellular matrix depend on the particular strain, as well as the minimal inhibitory concentration (MIC) for the antibiotics. Increased values were found for bacteria organized in biofilms when compared to the respective planktonic forms, except for isolates Kp45 and Kp2948, the MIC values for which remained unchanged for fosfomycin. Altogether, these results showed that the emergence of antimicrobial resistance among bacteria responsible for HAI is a multifactorial phenomenon dependent on antibiotics and on bacteria/biofilm features.
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- 2014
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134. MANAGEMENT- KEY PLAYER OR EXECUTIVE POWER OF AN ENTITY IN RURAL AREA IN THE TRANSITION PROCESS
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Ion CERTAN and Maria BANARI
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development ,management ,market economy ,policy ,rural area ,Agriculture (General) ,S1-972 - Abstract
Since independence, Republic of Moldova aligns among the developed countries and this process is related to thetransition from the command to market economy. This process is lengthy, laborious and often contradictory,especially in rural areas. In the given article we consider the process of transition in rural areas fromkolkhozy/collective farms to market economy entities through the prism of organizational policies, activities, staff ofcontemporary agricultural enterprises based on example of Brinzenii Vechi village, Telenesti, Moldova. That will befollowed by some conclusions on the role of management as well as the impact on sustainability of localdevelopment.
- Published
- 2014
135. HERV-K113 Is Not Associated with Multiple Sclerosis in a Large Family-Based Study.
- Author
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David L. Moyes, An Goris, Maria Ban, Alistair Compston, David J. Griffiths, Stephen Sawcer, and Patrick J. Venables
- Abstract
ABSTRACTNumerous studies have invoked a role for retroviruses in multiple sclerosis (MS). Most have identified human endogenous retroviruses (HERVs) as possible etiological agents. The majority of HERVs originate from ancestral infection and then become progressively disabled by mutations over millions of years of primate evolution. Their presence in 100 of healthy humans, together with the paucity of functional retroviral genes, argues strongly against a causal role in disease. Recently, a new class of insertionally polymorphic HERVs has been described that is present in only a proportion of the population. One of them, HERV-K113, is notable for open reading frames for all of its genes and is found in 028 of humans with widespread geographic and racial variation. Thus HERV-K113 is a credible candidate for causing disease in a manner comparable to infectious retroviruses. Genomic DNA samples from 951 patients with MS were tested for the presence of the HERV-K113 allele by PCR, with their unaffected parents (n1902) acting as controls. HERV-K113 provirus was found in 70 out of 951 (7.36) patients with MS and was not significantly increased compared to the combined parent group (6.52). The results do not support an association between this endogenous retrovirus and MS. This study also emphasizes the need for large cohorts with controls for race and geographic location when examining possible links between polymorphic HERVs and disease. [ABSTRACT FROM AUTHOR]
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- 2008
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136. Refining genetic associations in multiple sclerosis
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Åslaug R. Lorentzen, Bertram Müller-Myhsok, David R. Booth, Jonathan L. Haines, Françoise Clerget-Darpoux, Anne Spurkland, David A. Hafler, P. Villoslada, Bertrand Fontaine, Graeme J. Stewart, An Goris, Stephen Sawcer, Virpi M. Leppä, Tania Mihalova, Daniela Galimberti, Alastair Compston, Xavier Montalban, Margaret A. Pericak-Vance, Hanne F. Harbo, Antje Kroner, Colin M. Graham, A. Oturai, Janna Saarela, Sandra D'Alfonso, A Ivinson, Paola Naldi, Stephen L. Hauser, Tomas Olsson, C M van Duijn, Manuel Comabella, R Q Hintzen, Rita Dobosi, Ingrid Kockum, John D. Rioux, Amie Walton, J. Hoksenberg, P. L. De Jager, L. F. Barcellos, Francesco Cucca, Bénédicte Dubois, Maria Ban, Mark J. Daly, Koen Vandenbroeck, Helle Bach Søndergaard, Laura Bergamaschi, Peter Rieckmann, Neil Robertson, Elisabeth Gulowsen Celius, David Sexton, Robert Heard, Florian Holsboer, Finn Sellebjerg, Marie-Claude Babron, Frank Weber, Leena Peltonen, Stanley Hawkins, Jacob L. McCauley, Isabelle Cournu-Rebeix, J. Hillert, Maria Giovanna Marrosu, Marco Salvetti, A. Palotie, Gillian Ingram, Franca Rosa Guerini, and Clive Hawkins
- Subjects
Empirical data ,medicine.medical_specialty ,Multiple Sclerosis ,Genetic Linkage ,Reflection and Reaction ,Bayesian probability ,Complex disease ,03 medical and health sciences ,0302 clinical medicine ,medicine ,False positive paradox ,Humans ,Genetic Predisposition to Disease ,Psychiatry ,030304 developmental biology ,Genetic association ,0303 health sciences ,business.industry ,Multiple sclerosis ,Chromosome Mapping ,medicine.disease ,3. Good health ,Neurology (clinical) ,business ,True positive rate ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Genome-wide association studies involve several hundred thousand markers and, even when quality control is scrupulous, are invariably confounded by residual uncorrected errors that can falsely inflate the apparent difference between cases and controls (so-called genomic inflation). As a consequence such studies inevitably generate false positives alongside genuine associations. By use of Bayesian logic and empirical data, the Wellcome Trust Case Control Consortium suggested that association studies in complex disease should involve at least 2000 cases and 2000 controls, at which level they predicted that p values of less than 5×10 −7 would more commonly signify true positives than false positives.
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137. En investigación biomédica, un olvido histórico: la persona
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María Bandrés Sánchez and Marisa Tsuchida Fernández
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Medicine - Abstract
Sin resumen disponible
- Published
- 2016
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138. Estudo da correlação entre molusco contagioso e dermatite atópica em crianças A study of the correlation between molluscum contagiosum and atopic dermatitis in children
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Maria Bandeira de Melo Paiva Seize, Mayra Ianhez, and Silmara da Costa Pereira Cestari
- Subjects
Dermatite atópica ,Eczema ,Molusco contagioso ,Dermatitis, atopic ,Molluscum contagiosum ,Dermatology ,RL1-803 - Abstract
FUNDAMENTOS: É bastante divulgado, sem a fundamentação científica necessária, que a infecção por molusco contagioso tende a ser mais frequente e de maior intensidade nos pacientes acometidos por dermatite atópica. Tal fato motivou a realização deste trabalho. OBJETIVOS: Avaliar a prevalência de associação de dermatite atópica e molusco contagioso; avaliar se, nos pacientes com dermatite atópica, a infecção por molusco contagioso é mais recorrente e/ou disseminada e se a ocorrência de eczema perimolusco, prurido e/ou infecção é mais prevalente que nos pacientes sem dermatite atópica. MÉTODOS: Avaliaram-se 284 crianças de ambos os sexos, com diagnóstico de molusco contagioso e/ ou dermatite atópica. RESULTADOS: Apenas 13,4% dos pacientes apresentavam ambas as doenças. O número de áreas anatômicas afetadas por molusco contagioso, a ocorrência de eczema perimolusco e prurido foram maiores nos pacientes com dermatite atópica associada. Não houve diferença significativa de frequência de infecção secundária associada às lesões de molusco contagioso nos pacientes com e sem dermatite atópica. CONCLUSÃO: A prevalência da ocorrência de dermatite atópica e molusco contagioso associados foi baixa. Não houve diferença significativa na recorrência da infecção por molusco contagioso e na quantidade de lesões nos pacientes com e sem dermatite atópica. O número de áreas anatômicas afetadas por lesões de molusco contagioso, a presença de eczema perimolusco e de prurido foram maiores nos pacientes com dermatite atópica. Não houve diferença significativa na ocorrência de infecção bacteriana secundária nos grupos com e sem dermatite atópicaBACKGROUND: Although no scientific evidence has yet been published, it is widely understood that molluscum contagiosum tends to be more common and more intense in patients with atopic dermatitis. This lack of evidence led to the development of the present study. OBJECTIVES: To evaluate the prevalence of the association between atopic dermatitis and molluscum contagiosum; to evaluate whether molluscum contagiosum is more likely to be recurrent and/or disseminated in patients with atopic dermatitis and whether the occurrence of eczema surrounding the molluscum contagiosum lesions, pruritus and/or infection is more prevalent in these patients compared to patients without atopic dermatitis. METHODS: A total of 284 children of both sexes with a diagnosis of molluscum contagiosum and/or atopic dermatitis were evaluated. RESULTS: Only 13.4% of the patients had both conditions. The number of anatomical areas affected by molluscum contagiosum and the occurrence of surrounding eczema and pruritus was greater in the patients who also had atopic dermatitis. There was no statistically significant difference in the frequency of secondary infection associated with the molluscum contagiosum lesions between the patients who had atopic dermatitis and those who did not. CONCLUSION: The prevalence of atopic dermatitis associated with molluscum contagiosum was low. There was no statistically significant difference in the recurrence rates associated with molluscum contagiosum or in the number of lesions between the patients who had atopic dermatitis and those who did not. The number of anatomical areas affected by the molluscum contagiosum lesions and the presence of surrounding eczema and pruritus were higher in the patients with atopic dermatitis. There was no statistically significant difference in the occurrence of secondary bacterial infection between the groups with and without atopic dermatitis
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- 2011
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139. Padrões dermatoscópicos do molusco contagioso: estudo de 211 lesões confirmadas por exame histopatológico Dermoscopic patterns of molluscum contagiosum: a study of 211 lesions confirmed by histopathology
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Mayra Ianhez, Silmara da Costa P Cestari, Mauro Yoshiaki Enokihara, and Maria Bandeira de Paiva Melo Seize
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Dermatologia ,Equipamentos para diagnóstico ,Molusco contagioso ,Dermatology ,Diagnostic equipment ,Microscopy ,Molluscum contagiosum ,RL1-803 - Abstract
FUNDAMENTOS: Embora de fácil diagnóstico, o molusco contagioso pode apresentar-se como lesões inflamadas, únicas ou pequenas de difícil diagnóstico. OBJETIVO: Descrever características dermatoscópicas do molusco contagioso e comparar achados do exame clínico e dermatoscópico. MÉTODOS: Avaliou-se clínica e dermatoscopicamente lesões confirmadas pela histopatologia em 57 pacientes. RESULTADOS: Nos exames clínico e dermatoscópico de 211 lesões, foram visualizados orifícios em 50,24% e 96,68% das lesões e vasos em 6,16% e 89,10% delas, respectivamente. Os padrões vasculares encontrados em 188 lesões que apresentaram vasos à dermatoscopia foram coroa (72,34%), radial (54,25%) e puntiforme (20,21%). Metade das 188 lesões apresentou padrão vascular combinado, sendo o padrão em flor (novo padrão vascular) responsável por 19,68%. Foram identificados mais orifícios e vasos no exame dermatoscópico que no clínico, inclusive naquelas com inflamação, eczema perilesional e de tamanho pequeno. Vasos puntiformes relacionaram-se com inflamação, escoriação e eczema perilesional. CONCLUSÕES: A dermatoscopia das lesões de molusco mostrou-se superior ao exame dermatológico mesmo quando seu diagnóstico clínico torna-se difícil. A presença de orifícios, vasos e padrões vasculares específicos auxilia no seu diagnóstico e na diferenciação de outras lesões de pele.BACKGROUNDS: Although easily diagnosed, molluscum contagiosum may present as a single lesion or as several small, inflamed lesions of difficult diagnosis. OBJECTIVE: To describe the dermoscopic characteristics of molluscum contagiosum and to compare the findings from clinical examination and dermoscopy. METHODS: Histopathologically confirmed lesions were evaluated clinically and dermoscopically in 57 patients. RESULTS: At clinical examination and dermoscopy of 211 lesions, orifices were visualized in 50.24% and 96.68% of the lesions, and vessels in 6.16% and 89.10%, respectively. The vascular patterns found in the 188 lesions in which vessels were found at dermoscopy were the crown (72.34%), radial (54.25%) and punctiform patterns (20.21%). Half of the 188 lesions had a combination of vascular patterns, with the flower pattern (a new vascular pattern) being found in 19.68% of cases. More orifices and vessels were identified at dermoscopy than at clinical examination, including cases with inflammation or perilesional eczema and small lesions. Punctiform vessels were associated with inflammation, excoriation and perilesional eczema. CONCLUSIONS: Dermoscopy performed on molluscum contagiosum lesions proved superior to dermatological examination even in cases in which clinical diagnosis was difficult. The presence of orifices, vessels and specific vascular patterns aids diagnosis, including differential diagnosis with other types of skin lesion.
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- 2011
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140. Urticária aquagênica familiar: relato de dois casos e revisão da literatura Familial aquagenic urticaria: report of two cases and literature review
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Maria Bandeira de Melo Paiva Seize, Mayra Ianhez, Patrícia Karla de Souza, Osmar Rotta, and Silmara da Costa Pereira Cestari
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Água ,Antagonistas dos receptores H1 de histamina ,Prurido ,Urticária ,Histamine H1 antagonists ,Pruritus ,Urticaria ,Water ,Dermatology ,RL1-803 - Abstract
Urticária aquagênica é forma rara de urticária física caracterizada por aparecimento de urticas após o contato com água, independente da temperatura. Há poucos casos descritos de urticária aquagênica e, destes, somente cinco da forma familiar. Apresentamos o primeiro relato de urticária aquagênica familiar no Brasil, acometendo mãe e filha. Ambas apresentavam urticas, principalmente após banho de chuveiro, independentemente da temperatura da água. A mãe referia ter o quadro há quatro anos, e a filha, desde o nascimento. Para diagnóstico, foram realizados testes de provocação com água, com aparecimento de lesões em ambas, e testes com dermografômetro, com cubo de gelo envolvido em plástico e de provocação para urticária colinérgica, sem o aparecimento de lesões, excluindo assim outras formas de urticária física.Aquagenic urticaria is a rare form of physical urticaria, characterized by pruritic wheals that appear following contact with water, independently of its temperature. There are few reports of cases of aquagenic urticaria, and only five include the familial form. We present the first case of familial aquagenic urticaria in Brazil (mother and daughter). Both patients presented wheals following contact with water, especially when showering, regardless of its temperature. The mother reported onset of urticaria four years before and the daughter presented wheals since birth. For diagnostic purposes, they were submitted to a challenge test with water, and both subjects presented wheals, as well as to tests using ice cubes in plastic bag with dermographometer and challenge tests for cholinergic urticaria, with no appearance of lesions, excluding other forms of physical urticaria.
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- 2009
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141. Birth weight and coronary artery disease. The effect of gender and diabetes
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Maria Banci, Patrizia Saccucci, Alessandro Dofcaci, Ilaria Sansoni, Andrea Magrini, Egidio Bottini, Fulvia Gloria-Bottini
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Biology (General) ,QH301-705.5 - Abstract
Background: The developmental origin theory of coronary heart disease proposes that undernutrition in utero permanently changes body functions and metabolism leading to an increased risk of coronary artery diseases (CAD) in adult life. Some studies support this theory but others suggest that birth weight (BW) is not a major risk factor for cardiovascular diseases. Gender differences concerning the association between BW and risk factors for CAD have been reported in some studies but not in others. In this paper we have analyzed the effect of gender and diabetes on the relationship between BW and CAD in the White population of Rome. Material and Methods: 226 subjects admitted to the Hospital for non fatal CAD from the White population of Rome were studied. 395 consecutive newborn infants studied in the same population in the years 1968-1972 were considered for comparison. Results: Among subjects with CAD, reliable information on BW was obtained in 127 subjects. The distribution of BW in CAD depends on gender (p=0.009). In females with CAD there is a tendency toward low BW, while in males with CAD there is a tendency toward high BW. These associations are very marked in non-diabetic subjects with CAD (p=.001), while no significant association is observed in diabetic subjects (p=0.557). Conclusion: Our data confirm the association between BW and CAD and suggest that the association depends on gender and is influenced by diabetes.
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- 2009
142. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis
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Laura Bergamaschi, Jacob L. McCauley, Jorge R. Oksenberg, Hanne F. Harbo, Jeannette Lechner-Scott, Rodney J. Scott, Leena Peltonen, Margaret A. Pericak-Vance, Rita Dobosi, Ingrid Kockum, Jonathan L. Haines, Lisa F. Barcellos, An Goris, Alastair Compston, David R. Booth, Sandra D'Alfonso, David A. Hafler, Graeme J. Stewart, Stephen Sawcer, Maurizio Leone, Jenny Link, Virpi Leppa, Stephen L. Hauser, Anu Kemppinen, Philip L. De Jager, Bertrand Fontaine, Maria Ban, Mathew B Cox, Åslaug R. Lorentzen, Anne Spurkland, Elisabeth Gulowsen Celius, Amie Baker, Janna Saarela, Bénédicte Dubois, Neil Robertson, Tomas Olsson, Isabelle Cournu-Rebeix, David Sexton, Robert Heard, Jan Hillert, Adrian J. Ivinson, and Tuula Pirttilä
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Genetics ,0303 health sciences ,Multiple Sclerosis ,Association (object-oriented programming) ,Multiple sclerosis ,Genetic Variation ,Kinesins ,Computational biology ,Biology ,medicine.disease ,Article ,Introns ,03 medical and health sciences ,0302 clinical medicine ,Case-Control Studies ,medicine ,Humans ,Genetic Predisposition to Disease ,030217 neurology & neurosurgery ,030304 developmental biology ,Genome-Wide Association Study - Abstract
The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
143. Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells
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Ann-Christine Syvänen, Louis Letourneau, Catherine Laprise, Maria Ban, Guillaume Bourque, Andréanne Morin, Jonas Carlsson, Maxime Caron, Lars Rönnblom, Stephen Sawcer, Johanna K. Sandling, Bing Ge, Alexandre Montpetit, Mark Lathrop, Tomi Pastinen, Tony Kwan, Karolina Tandre, Sawcer, Stephen [0000-0001-7685-0974], and Apollo - University of Cambridge Repository
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0301 basic medicine ,T-Lymphocytes ,DNA Mutational Analysis ,Quantitative Trait Loci ,Capture ,Genome-wide association study ,Biology ,Genome ,DNA sequencing ,Transcriptome ,03 medical and health sciences ,Genetics ,Humans ,Genetics(clinical) ,capture ,Alleles ,Genetics (clinical) ,Immune disease ,Medicinsk genetik ,Sequence Analysis, RNA ,Gene Expression Profiling ,rare variants ,Molecular Sequence Annotation ,Rare variants ,Human genetics ,3. Good health ,030104 developmental biology ,Regulatory sequence ,gene expression ,Next-generation sequencing ,immune disease ,DNase I hypersensitive site ,next-generation sequencing ,Gene expression ,DNA microarray ,Medical Genetics ,Genome-Wide Association Study ,Research Article - Abstract
Background The observation that the genetic variants identified in genome-wide association studies (GWAS) frequently lie in non-coding regions of the genome that contain cis-regulatory elements suggests that altered gene expression underlies the development of many complex traits. In order to efficiently make a comprehensive assessment of the impact of non-coding genetic variation in immune related diseases we emulated the whole-exome sequencing paradigm and developed a custom capture panel for the known DNase I hypersensitive site (DHS) in immune cells – “Immunoseq”. Results We performed Immunoseq in 30 healthy individuals where we had existing transcriptome data from T cells. We identified a large number of novel non-coding variants in these samples. Relying on allele specific expression measurements, we also showed that our selected capture regions are enriched for functional variants that have an impact on differential allelic gene expression. The results from a replication set with 180 samples confirmed our observations. Conclusions We show that Immunoseq is a powerful approach to detect novel rare variants in regulatory regions. We also demonstrate that these novel variants have a potential functional role in immune cells. Electronic supplementary material The online version of this article (doi:10.1186/s12920-016-0220-7) contains supplementary material, which is available to authorized users.
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144. Insights on Klebsiella pneumoniae Biofilms Assembled on Different Surfaces Using Phenotypic and Genotypic Approaches
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Maria Bandeira, Vítor Borges, João P. Gomes, Aida Duarte, and Luisa Jordao
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biofilms ,Klebsiella pneumoniae ,electron microscopy ,extracellular polymeric substances (EPS) ,whole genome sequencing (WGS) ,healthcare associated infections (HAIs) ,Biology (General) ,QH301-705.5 - Abstract
Klebsiella pneumoniae is a prominent etiological agent of healthcare associated infections (HAIs). In this context, multidrug-resistant and biofilm-producing bacteria are of special public health concern due to the difficulties associated with treatment of human infections and eradication from hospital environments. Here, in order to study the impact of medical devices-associated materials on the biofilm dynamics, we performed biofilm phenotypic analyses through a classic and a new scanning electron microscopy (SEM) technique for three multidrug-resistant K. pneumoniae isolates growing on polystyrene and silicone. We also applied whole-genome sequencing (WGS) to search for genetic clues underlying biofilm phenotypic differences. We found major differences in the extracellular polymeric substances (EPS) content among the three strains, which were further corroborated by in-depth EPS composition analysis. WGS analysis revealed a high nucleotide similarity within the core-genome, but relevant differences in the accessory genome that may account for the detected biofilm phenotypic dissimilarities, such as genes already associated with biofilm formation in other pathogenic bacteria (e.g., genes coding haemogglutinins and haemolysins). These data reinforce that the research efforts to defeat bacterial biofilms should take into account that their dynamics may be contingent on the medical devices-associated materials.
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- 2017
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145. Mobile Learning – Begriff, Modelle, Forschung
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Regina Parzl and Maria Bannert
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Mobile Learning ,E-Learning ,educational media ,media education ,media didactics ,learning and teaching research ,formal education ,Education - Abstract
This overview focuses Mobile Learning (M-Learning) from an educational point of view. M-Learning, which found its way into different educational contexts since the middle of the 1990s, is a dynamic and interdisciplinary field. It is dynamic because of the rapid development of information and communication technology and the partly huge resulting changings. It is interdisciplinary because mobile technology and learning concern different scientific disciplines. Different points of view and the field´s complexity are major reasons for missing a consistent definition of the term M-Learning. This paper aims to show the current state of the art in research from an educational point of view. Therefore at first it shows important components of the term M-Learning. Afterwards important didactic models and theories will be introduced and commented. Based on this theoretical background the paper shows a frame that pitches starting points for educational research. Finally, corresponding research is introduced in order to present the current state of the art. By doing so the prospective need of educational research in the M-Learning field shall be demonstrated.
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- 2013
146. New Perspectives on Integrating Self-Regulated Learning at School
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Bracha Kramarski, Annemie Desoete, Maria Bannert, Susanne Narciss, and Nancy Perry
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Education (General) ,L7-991 - Published
- 2013
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147. Changes in pumpkin seed oil during heating
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Evangelos S. Lazos, Jhon Tsaknis, and Maria Bante
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continuous heating ,intermittent heating ,physicochemical properties (changes) ,pumpkin seed oil ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Purified pumpkin seed oil was heated either continuously or intermittently for 10 hours at 180±5°C, and occurring changes were evaluated. Free fatty acids (FFA), peroxide value (PV), colour, polar compounds and viscosity increased, while iodine value and unsaturation decreased. Intermittent heating had the more pronounced effect on these changes. Fatty acid profile determination showed non-significant changes in palmitic (C16:0), arachidic (C20:0) and oleic (018:1) acids during heating. Statistically significant decreases were observed in linoleic (C18:2) acid content. These decreases also caused significant increases in stearic (C18:0) acid content. Of the tocopherols, only α-tocopherol was detected, which was reduced during purification and bleaching to 33%. The 10-hour continuous and intermittent heating caused an additional 14 and 23 % loss respectively. High correlations were obtained between FFA and polar compounds, PV and polar compounds, viscosity and polar compounds, IV and unsaturation, and linoleic acid and polar compounds.
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- 1995
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148. Kerion Celsi por Microsporum gypseum
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Coaraci Melo-Monteiro, Carlos José Martins, Cristina de Sousa Monteiro, Maria Bandeira de Melo Paiva, and Renato de Oliveira Fagundes
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arthrodermataceae ,criança ,microsporum ,Dermatology ,RL1-803 - Abstract
Os autores apresentam um caso de Kerion Celsi por Microsporum gypseum em criança do sexo masculino,de 3 anos de idade, natural e procedente do Rio de Janeiro. Revisa-se a literatura, demonstrando a importância do caso.
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- 2003
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149. A Case of Isolated Left Ventricular Noncompaction with Basal ECG-Tracing Strongly Suggestive for Type-2 Brugada Syndrome
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Maria Banci, Roberta Martinoli, Alessandro Dofcaci, Stefano Piccirilli, Federica Papetti, Ilaria Sansoni, and Patrizia Saccucci
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Isolated left ventricular noncompaction (ILVNC) is a cardiomyopathy caused by intrauterine arrest of compaction of the myocardial fibres and meshwork, an important process in myocardial development. ILVNC is clinically accompanied by depressed ventricular function, arrhythmias, and systemic embolization. We reported a case of ILVNC with basal ECG-tracing strongly suggestive for type-2 Brugada syndrome (BrS). Up to now, this is the first report investigating the association between ILVNC and this particular ECG pattern.
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- 2011
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150. Progettare supporti cognitivi per l'apprendimento con ipermedia
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Maria Bannert
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Tecnologie didattiche ,Tecnologie per l'apprendimento ,Metacognizione e ambienti per l'apprendimento ,supporto metacognitivo ,apprendimento con ipermedia ,acquisizione della conoscenza ,Special aspects of education ,LC8-6691 - Abstract
L’obiettivo di questo studio è indagare l’effetto che il supporto metacognitivo può avere nell’apprendimento con gli ipermedia. Si ipotizza che sollecitare gli studenti alla riflessione metacognitiva influenzi il processo di apprendimento, incoraggiandoli a manifestare più spesso comportamenti metacognitivi e favorire una migliore performance di apprendimento. Il supporto metacognitivo utilizzato è stato sviluppato sulla base di esistenti ricerche e testato sperimentalmente. Attraverso un’azione indiretta basata sull’uso di prompt, gli studenti del gruppo sperimentale (n=20) sono stati stimolati ad esercitare un’attività metacognitiva durante l’apprendimento. Nessun supporto metacognitivo è stato offerto al gruppo di controllo (n=20). I risultati del processo di apprendimento confermano l’effetto positivo del supporto metacognitivo soprattutto per quegli studenti che hanno applicato il supporto offerto seguendo le modalità per cui esso è stato progettato.
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- 2010
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