8,286 results on '"Manson, JoAnn E"'
Search Results
102. Relation of serum BDNF to major depression and exploration of mechanistic roles of serum BDNF in a study of vitamin D3 and omega-3 supplements for late-life depression prevention
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Vyas, Chirag M., Mischoulon, David, Chang, Grace, Reynolds, Charles F., III, Cook, Nancy R., Weinberg, Alison, Copeland, Trisha, Bubes, Vadim, Bradwin, Gary, Lee, I-Min, Buring, Julie E., Mora, Samia, Rifai, Nader, Manson, JoAnn E., and Okereke, Olivia I.
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- 2023
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103. Association of Sedentary Time and Incident Heart Failure Hospitalization in Postmenopausal Women
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LaMonte, Michael J, Larson, Joseph C, Manson, JoAnn E, Bellettiere, John, Lewis, Cora E, LaCroix, Andrea Z, Bea, Jennifer W, Johnson, Karen C, Klein, Liviu, Noel, Corinna A, Stefanick, Marcia L, Wactawski-Wende, Jean, and Eaton, Charles B
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Prevention ,Heart Disease ,Aging ,Clinical Research ,Good Health and Well Being ,Aged ,Female ,Heart Failure ,Hospitalization ,Humans ,Incidence ,Middle Aged ,Postmenopause ,Prospective Studies ,Sedentary Behavior ,Surveys and Questionnaires ,United States ,heart disease ,heart failure ,hypertension ,sedentary behavior ,women ,Biochemistry and Cell Biology ,Cardiorespiratory Medicine and Haematology ,Medical Physiology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Medical physiology - Abstract
BackgroundThe 2018 US Physical Activity Guidelines recommend reducing sedentary behavior (SB) for cardiovascular health. SB's role in heart failure (HF) is unclear.MethodsWe studied 80 982 women in the Women's Health Initiative Observational Study, aged 50 to 79 years, who were without known HF and reported ability to walk ≥1 block unassisted at baseline. Mean follow-up was 9 years for physician-adjudicated incident HF hospitalization (1402 cases). SB was assessed repeatedly by questionnaire. Time-varying total SB was categorized according to awake time spent sitting or lying down (≤6.5, 6.6-9.5, >9.5 h/d); sitting time (≤4.5, 4.6-8.5, >8.5 h/d) was also evaluated. Hazard ratios and 95% CI were estimated using Cox regression.ResultsControlling for age, race/ethnicity, education, income, smoking, alcohol, menopausal hormone therapy, and hysterectomy status, higher HF risk was observed across incremental tertiles of time-varying total SB (hazard ratios [95% CI], 1.00 [referent], 1.15 [1.01-1.31], 1.42 [1.25-1.61], trend P
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- 2020
104. Walking Volume and Speed Are Inversely Associated With Incidence of Treated Hypertension in Postmenopausal Women
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Miller, Connor R, Wactawski-Wende, Jean, Manson, JoAnn E, Haring, Bernhard, Hovey, Kathleen M, Laddu, Deepika, Shadyab, Aladdin H, Wild, Robert A, Bea, Jennifer W, Tinker, Lesley F, Martin, Lisa W, Nguyen, Patricia K, Garcia, Lorena, Andrews, Christopher A, Eaton, Charles B, Stefanick, Marcia L, LaMonte, Michael J, and Investigators*, WHI
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Aging ,Rehabilitation ,Hypertension ,Cardiovascular ,Clinical Research ,Aged ,Antihypertensive Agents ,Blood Pressure ,Exercise ,Female ,Humans ,Incidence ,Middle Aged ,Postmenopause ,Risk ,Walking ,Walking Speed ,blood pressure ,epidemiology ,exercise ,prevention ,women ,WHI Investigators* ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Few studies have evaluated hypertension incidence in relation to walking, which is a common physical activity among adults. We examined the association between walking and hypertension incidence in 83 435 postmenopausal women who at baseline were aged 50 to 79 years, without known hypertension, heart failure, coronary heart disease, or stroke, and reported the ability to walk at least one block without assistance. Walking volume (metabolic equivalent hours per week) and speed (miles per hour) were assessed by questionnaire. Incident physician-diagnosed hypertension treated with medication was ascertained through annual questionnaires. During a mean 11-year follow-up, 38 230 hypertension cases were identified. After adjustment for covariates including nonwalking activities, a significant inverse association with hypertension was observed across categories of baseline walking volume (0 [referent], >0-3.5, 3.6-7.5, and >7.5 metabolic equivalent hours per week), hazard ratio: 1.00 (referent), 0.98, 0.95, 0.89; trend P4 miles per hour) also were associated with lower hypertension risk, hazard ratio: 1.00 (referent), 1.07, 0.95, 0.86, 0.79; trend P7.5 metabolic equivalent hours per week) and at faster speeds (≥2 miles per hour) is associated with lower hypertension risk in postmenopausal women. Walking should be encouraged as part of hypertension prevention in older adults.
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- 2020
105. Chocolate Consumption in Relation to All-Cause and Cause-Specific Mortality in Women: The Women’s Health Initiative
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Sun, Yangbo, Liu, Buyun, Snetselaar, Linda G., Wallace, Robert B., Shadyab, Aladdin H., Chen, Guo-Chong, Shikany, James M., Manson, JoAnn E., and Bao, Wei
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- 2023
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106. Association between urinary phthalate biomarker concentrations and adiposity among postmenopausal women
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Vieyra, Gabriela, Hankinson, Susan E., Oulhote, Youssef, Vandenberg, Laura N., Tinker, Lesley, Manson, JoAnn E., Shadyab, Aladdin H., Thomson, Cynthia A., Bao, Wei, Allison, Matthew, Odegaard, Andrew O., and Reeves, Katherine W.
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- 2023
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107. Dual-Outcome Intention-to-Treat Analyses in the Women's Health Initiative Randomized Controlled Hormone Therapy Trials.
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Prentice, Ross L, Aragaki, Aaron K, Chlebowski, Rowan T, Zhao, Shanshan, Anderson, Garnet L, Rossouw, Jacques E, Wallace, Robert, Banack, Hailey, Shadyab, Aladdin H, Qi, Lihong, Snively, Beverly M, Gass, Margery, and Manson, JoAnn E
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Humans ,Gallbladder Diseases ,Cardiovascular Diseases ,Estrogens ,Conjugated (USP) ,Estrogen Replacement Therapy ,Incidence ,Risk Factors ,Postmenopause ,Aged ,Middle Aged ,United States ,Female ,Fractures ,Bone ,Randomized Controlled Trials as Topic ,Medroxyprogesterone Acetate ,Intention to Treat Analysis ,Cox model ,cancer ,cardiovascular disease ,diabetes ,dual outcomes ,fractures ,hazard ratio ,menopausal hormone therapy ,Clinical Research ,Clinical Trials and Supportive Activities ,Estrogen ,Contraception/Reproduction ,Aging ,Good Health and Well Being ,Mathematical Sciences ,Medical and Health Sciences ,Epidemiology - Abstract
Dual-outcome intention-to-treat hazard rate analyses have potential to complement single-outcome analyses for the evaluation of treatments or exposures in relation to multivariate time-to-response outcomes. Here we consider pairs formed from important clinical outcomes to obtain further insight into influences of menopausal hormone therapy on chronic disease. As part of the Women's Health Initiative, randomized, placebo-controlled hormone therapy trials of conjugated equine estrogens (CEE) among posthysterectomy participants and of these same estrogens plus medroxyprogesterone acetate (MPA) among participants with an intact uterus were carried out at 40 US clinical centers (1993-2016). These data provide the context for analyses covering the trial intervention periods and a nearly 20-year (median) cumulative duration of follow-up. The rates of multiple outcome pairs were significantly influenced by hormone therapy, especially over cumulative follow-up, providing potential clinical and mechanistic insights. For example, among women randomized to either regimen, hazard ratios for pairs defined by fracture during intervention followed by death from any cause were reduced and hazard ratios for pairs defined by gallbladder disease followed by death were increased, though these findings may primarily reflect single-outcome associations. In comparison, hazard ratios for diabetes followed by death were reduced with CEE but not with CEE + MPA, and those for hypertension followed by death were increased with CEE + MPA but not with CEE.
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- 2020
108. Social Relationships and Risk of Type 2 Diabetes Among Postmenopausal Women.
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Hendryx, Michael, Nicholson, Wanda, Manson, JoAnn E, Kroenke, Candyce H, Lee, Jennifer, Weitlauf, Julie C, Garcia, Lorena, Jonasson, Junmei M, Wactawski-Wende, Jean, and Luo, Juhua
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Aging ,Behavioral and Social Science ,Prevention ,Clinical Research ,Mental Health ,Nutrition ,Diabetes ,Obesity ,Depression ,Metabolic and endocrine ,Aged ,Diabetes Mellitus ,Type 2 ,Female ,Humans ,Interpersonal Relations ,Middle Aged ,Postmenopause ,Proportional Hazards Models ,Prospective Studies ,Risk Factors ,Social Networking ,Social Support ,Stress ,Psychological ,Social relationships ,Women ,Clinical Sciences ,Sociology ,Psychology ,Gerontology - Abstract
ObjectivesWe examined whether social relationship variables (social support, social strain, social network size, and stressful life events) were associated with risk of developing type 2 diabetes among postmenopausal women.Method139,924 postmenopausal women aged 50-79 years without prevalent diabetes at baseline were followed for a mean of 14 years. 19,240 women developed diabetes. Multivariable Cox proportional hazard models tested associations between social relationship variables and diabetes incidence after consideration of demographics, depressive symptoms, and lifestyle behaviors. We also examined moderating effects of obesity and race/ethnicity, and we tested whether social variable associations were mediated by lifestyle or depressive symptoms.ResultsCompared with the lowest quartile, women in the highest social support quartile had lower risk of diabetes after adjusting for demographic factors, health behaviors, and depressive symptoms (hazard ratio [HR] = 0.93, 95% confidence interval [CI] = 0.89-0.97). Social strain (HR = 1.09, 95% CI = 1.04-1.13) and stressful life events (HR = 1.10, 95% CI = 1.05-1.15) were associated with higher diabetes risks. The association between diabetes and social strain was stronger among African American women. Social relationship variables had direct relationships to diabetes, as well as indirect effects partially mediated by lifestyle and depressive symptoms.DiscussionSocial support, social strain, and stressful life events were associated with diabetes risk among postmenopausal women independently of demographic factors and health behaviors. In addition to healthy behaviors such as diet and physical activity, healthy social relationships among older women may be important in the prevention of diabetes.
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- 2020
109. Prospective association of obstructive sleep apnea risk factors with heart failure and its subtypes in postmenopausal women: The Women's Health Initiative.
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Koo, Patrick, Gorsi, Umama, Manson, JoAnn E, Allison, Matthew A, LaMonte, Michael J, Roberts, Mary B, Shadyab, Aladdin, and Eaton, Charles B
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Clinical Research ,Sleep Research ,Prevention ,Cardiovascular ,Lung ,Heart Disease ,Aging ,Female ,Heart Failure ,Humans ,Postmenopause ,Prognosis ,Prospective Studies ,Risk Factors ,Sleep Apnea ,Obstructive ,Stroke Volume ,Women's Health ,obstructive sleep apnea ,postmenopausal women ,HFpEF ,HFrEF ,Clinical Sciences ,Other Medical and Health Sciences ,Psychology ,Neurology & Neurosurgery - Abstract
Study objectivesThe relationship between obstructive sleep apnea (OSA) and heart failure (HF) incidence in postmenopausal women has been understudied, given the limited representation of women in heart failure studies. We investigated the relationship between OSA risk factors and HF and its subtypes in postmenopausal women.MethodsWe performed a prospective analysis on the adjudicated HF outcomes in the Women's Health Initiative from enrollment (1993-1998) to September 30, 2016. HF with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF) were defined as adjudicated acute HF hospitalization with EF ≥ 45% or < 45%, respectively. We employed Cox regression to examine the association between OSA risk factors and symptoms (individually and using a summary risk score) and time to first hospitalized HF.ResultsOf 42,362 women, 2,205 (5.21%) developed all HF, 1,162 (2.74%) women developed HFpEF, and 679 (1.60%) developed HFrEF. Individual OSA risk factors and symptoms, including obesity (hazard ratio = 1.33, 95% confidence interval [CI] 1.20-1.48), snoring (hazard ratio = 1.30, 95% CI 1.16-1.46), and hypertension (HR = 1.45, 95% CI 1.35-1.56), were positively associated with risk of HF and HFpEF, but only hypertension was associated with HFrEF. When examined as a summary risk score compared with those with none of the OSA risk factors, presence of each additional factor was significantly associated with increased risk of hospitalized HF in a dose-response fashion for HFpEF (P trend < .001), but not HFrEF (P trend = .26).ConclusionsOSA risk factors and symptoms were associated with HFpEF, but not HFrEF, among postmenopausal women and are largely dependent on body mass index, snoring, and hypertension.
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- 2020
110. Associations of social, physical, and financial factors with diet quality among older, community-dwelling women.
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Shikany, James M, Manson, JoAnn E, Shadyab, Aladdin H, Garcia, Lorena, Lewis, Cora E, Neuhouser, Marian L, Tinker, Lesley F, Beasley, Jeannette M, Beresford, Shirley AA, Zaslavsky, Oleg, Vitolins, Mara Z, Sealy-Jefferson, Shawnita, and Bae, Sejong
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Nutrition and Dietetics ,Nutrition ,Aging ,Prevention ,Behavioral and Social Science ,2.3 Psychological ,social and economic factors ,Aetiology ,Oral and gastrointestinal ,Aged ,Aged ,80 and over ,Cross-Sectional Studies ,Diet ,Diet ,Healthy ,Eating ,Female ,Humans ,Independent Living ,Diet quality ,Food frequency questionnaire ,Healthy Eating Index ,Older adults ,Women's Health Initiative ,Medical and Health Sciences ,Obstetrics & Reproductive Medicine ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
ObjectiveThis analysis examined whether specific social, physical, and financial factors were associated with diet quality among older, community-dwelling women.MethodsThis cross-sectional analysis was conducted in a subset of 6,094 community-dwelling Women's Health Initiative participants who completed a food frequency questionnaire, administered from 2012 to 2013, and a self-administered supplemental questionnaire, administered approximately 1 year later. The supplemental questionnaire included five questions assessing social, physical, and financial factors related to eating. Diet quality was assessed with the Healthy Eating Index-2010 (HEI-2010; range of 0-100; higher score indicates a higher quality diet). The total HEI-2010 score was calculated by summing individual scores representing the intake of nine adequacy components (beneficial food groups) and three moderation components (food groups to limit). Associations of responses to the five questions on the supplemental questionnaire with HEI-2010 scores were examined with multiple linear regression, adjusting for relevant covariates.ResultsMean ± standard deviation age of participants was 78.8 ± 6.7 years. Reporting eating fewer than two meals per day, having dental or other mouth problems causing problems with eating, and not always being able to shop, cook, or feed oneself were associated with statistically significantly lower HEI-2010 scores, compared with those not reporting these issues, after multivariable adjustment: 5.37, 2.98, and 2.39 lower scores, respectively (all P values
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- 2020
111. Comparison of nonfasting and fasting lipoprotein subfractions and size in 15,397 apparently healthy individuals: An analysis from the VITamin D and OmegA-3 TriaL
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Farukhi, Zareen M, Demler, Olga V, Caulfield, Michael P, Kulkarni, Krishnaji, Wohlgemuth, Jay, Cobble, Michael, Luttmann-Gibson, Heike, Li, Chunying, Nelson, John R, Cook, Nancy R, Buring, Julie E, Krauss, Ronald M, Manson, JoAnn E, and Mora, Samia
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Cardiovascular ,Clinical Research ,Nutrition ,Atherosclerosis ,Prevention ,Aged ,Clinical Trials as Topic ,Cross-Sectional Studies ,Fasting ,Female ,Healthy Volunteers ,Humans ,Lipoproteins ,Male ,Molecular Weight ,Postprandial Period ,Lipoprotein subfractions ,Nonfasting lipids ,Postprandial state ,Triglyceride-rich lipoproteins ,Medical Biochemistry and Metabolomics ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Medical biochemistry and metabolomics - Abstract
BackgroundElevated postprandial triglycerides reflect a proatherogenic milieu, but underlying mechanisms are unclear.ObjectiveWe examined differences between fasting and nonfasting profiles of directly measured lipoprotein size and subfractions to assess if postprandial triglycerides reflected increases in very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and remnants, or small dense lipid depleted LDL (sdLDL) particles.MethodsWe conducted a cross-sectional analysis of 15,397 participants (10,135 fasting; 5262 nonfasting [ .05).ConclusionsDirectly measured particle and cholesterol concentrations of VLDL, not sdLDL, were higher nonfasting and may partly contribute to the proatherogenicity of postprandial hypertriglyceridemia. These differences, although statistically significant, were small and may not fully explain the increased risk of postprandial hypertriglyceridemia.
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- 2020
112. Heart fat and carotid artery atherosclerosis progression in recently menopausal women: impact of menopausal hormone therapy: The KEEPS trial.
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El Khoudary, Samar R, Venugopal, Vidya, Manson, JoAnn E, Brooks, Maria M, Santoro, Nanette, Black, Dennis M, Harman, Mitchell, Naftolin, Frederick, Hodis, Howard N, Brinton, Eliot A, Miller, Virginia M, Taylor, Hugh S, and Budoff, Matthew J
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Myocardium ,Humans ,Carotid Artery Diseases ,Disease Progression ,Estradiol ,Estrogens ,Conjugated (USP) ,Estrogens ,Treatment Outcome ,Estrogen Replacement Therapy ,Administration ,Oral ,Administration ,Cutaneous ,Postmenopause ,Middle Aged ,Female ,Atherosclerosis ,Carotid Intima-Media Thickness ,Estrogen ,Biomedical Imaging ,Contraception/Reproduction ,Cardiovascular ,Clinical Trials and Supportive Activities ,Aging ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Carotid atherosclerosis ,Epicardial fat ,Menopause ,Paracardial fat ,Medical and Health Sciences ,Obstetrics & Reproductive Medicine - Abstract
ObjectiveHeart fat deposition has been linked to atherosclerosis, and both accelerate after menopause. Hormone therapy (HT) may differentially slow heart fat deposition and progression of atherosclerosis, depending on the specific HT agent or its route of administration. Our objective was to evaluate the effects of different HT agents, oral and transdermal, on associations between heart fat accumulation and atherosclerosis progression, measured by carotid intima-media thickness (CIMT), in recently menopausal women from the Kronos Early Estrogen Prevention Study (KEEPS) trial.MethodsKEEPS was a randomized, placebo-controlled trial of the effects of 0.45 mg/d oral conjugated equine estrogens (o-CEE) or 50 mcg/d transdermal 17β-estradiol (t-E2), compared with placebo, on 48 months progression of CIMT. Epicardial adipose tissue (EAT) and paracardial adipose tissue (PAT) volumes were quantified by computed tomography.ResultsIn all, 467 women (mean age [SD] 52.7 [2.5]; 78.2% White; 30% on o-CEE, 30.8% t-E2, 39.2% placebo) with heart fat volumes and CIMT at baseline and 48 months were included. EAT and PAT changes were not associated with CIMT progression; however, the assigned treatment significantly modified the association between PAT (but not EAT) change and CIMT progression. In the o-CEE group, adjusted CIMT progression was 12.66 μm (95% confidence interval [CI] 1.80, 23.52) lower than in t-E2 group (P = 0.02), and 10.09 μm (95% CI 0.79, 19.39) lower than in placebo group (P = 0.03), as per 1-SD increase in PAT.ConclusionCompared with t-E2, o-CEE appears to slow down the adverse effect of increasing PAT on progression of atherosclerosis. Whether this beneficial association is specific to CEE or to the oral route of CEE administration is unclear and should be assessed further.
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- 2020
113. Eating Pattern Response to a Low-Fat Diet Intervention and Cardiovascular Outcomes in Normotensive Women: The Women's Health Initiative.
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Van Horn, Linda, Aragaki, Aaron K, Howard, Barbara V, Allison, Matthew A, Isasi, Carmen R, Manson, JoAnn E, Neuhouser, Marian L, Mossavar-Rahmani, Yasmin, Thomson, Cynthia A, Vitolin, Mara Z, Wallace, Robert B, Prentice, Ross L, and WHI Investigators
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WHI Investigators ,cardiovascular outcomes ,food choices ,low-fat diet ,normotensive women ,self-selected dietary change ,vegetable protein - Abstract
BackgroundWomen without cardiovascular disease (CVD) or hypertension at baseline assigned to intervention in the Women's Health Initiative Dietary Modification (DM) trial experienced 30% lower risk of coronary heart disease (CHD), whereas results in women with hypertension or prior CVD could have been confounded by postrandomization use of statins.ObjectivesIntervention participants reported various self-selected changes to achieve the 20% total fat goals. Reviewed are intervention compared with comparison group HRs for CHD, stroke, and total CVD in relation to specific dietary changes in normotensive participants.MethodsDietary change was assessed by comparing baseline with year 1 FFQ data in women (n = 10,371) without hypertension or CVD at baseline with intake of total fat above the median to minimize biases due to use of the FFQ in trial eligibility screening.ResultsIntervention participants self-reported compensating reduced energy intake from total fat by increasing carbohydrate and protein. Specifically they increased plant protein, with those in the upper quartile (increased total protein by ≥3.3% of energy) having a CHD HR of 0.39 (95% CI: 0.22, 0.71), compared with 0.92 (95% CI: 0.57, 1.48) for those in the lower quartile of change (decreased total protein ≥0.6% of energy), with P-trend of 0.04. CHD HR did not vary significantly with change in percentage energy from carbohydrate, and stroke HR did not vary significantly with any macronutrient changes. Scores reflecting adherence to recommended dietary patterns including the Dietary Approaches to Stop Hypertension Trial and the Healthy Eating Index showed favorable changes in the intervention group.ConclusionsIntervention group total fat reduction replaced with increased carbohydrate and some protein, especially plant-based protein, was related to lower CHD risk in normotensive women without CVD who reported high baseline total fat intake. This trial was registered at clinicaltrials.gov as NCT00000611. Link to the WHI trial protocol: https://www.whi.org/about/SitePages/Dietary%20Trial.aspx.
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- 2020
114. Prediagnostic plasma polyunsaturated fatty acids and the risk of amyotrophic lateral sclerosis.
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O'Reilly, Éilis J, Bjornevik, Kjetil, Furtado, Jeremy D, Kolonel, Laurence N, Le Marchand, Loic, McCullough, Marjorie L, Stevens, Victoria L, Shadyab, Aladdin H, Snetselaar, Linda, Manson, JoAnn E, and Ascherio, Alberto
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Nutrition ,ALS ,Rare Diseases ,Neurodegenerative ,Clinical Research ,Brain Disorders ,Aged ,Amyotrophic Lateral Sclerosis ,Biomarkers ,Fatty Acids ,Unsaturated ,Female ,Humans ,Male ,Middle Aged ,Prodromal Symptoms ,Risk Factors ,Sex Factors ,Clinical Sciences ,Neurosciences ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
ObjectiveTo examine the association between prediagnostic plasma polyunsaturated fatty acids levels (PUFA) and amyotrophic lateral sclerosis (ALS).MethodsWe identified 275 individuals who developed ALS while enrolled in 5 US prospective cohorts, and randomly selected 2 controls, alive at the time of the case diagnosis, matched on cohort, birth year, sex, ethnicity, fasting status, and time of blood draw. We measured PUFA, expressed as percentages of total fatty acids, using gas liquid chromatography and used conditional logistic regression to estimate risk ratios (RR) and 95% confidence intervals (CI) for the association between PUFA and ALS.ResultsThere was no association between total, n-3, and n-6 PUFA, eicosapentaenoic acid, or docosapentaenoic acid levels and ALS. Higher plasma α-linolenic acid (ALA) in men was associated with lower risk of ALS in age- and matching factor-adjusted analyses (top vs bottom quartile: RR = 0.21 [95% CI 0.07, 0.58], p for trend = 0.004). In women, higher plasma arachidonic acid was associated with higher risk (top vs bottom quartile: RR = 1.65 [95% CI 0.99, 2.76], p for trend = 0.052). Multivariable adjustment, including correlated PUFA, did not change the findings for ALA and arachidonic acid. In men and women combined, higher plasma docosahexaenoic acid (DHA) was associated with higher risk of ALS (top vs bottom quartile: RR = 1.56 [95% CI 1.01, 2.41], p for trend = 0.054), but in multivariable models the association was only evident in men.ConclusionsThe majority of individual PUFAs were not associated with ALS. In men, ALA was inversely and DHA was positively related to risk of ALS, while in women arachidonic acid was positively related. These findings warrant confirmation in future studies.
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- 2020
115. The Relation of Optimism to Relative Telomere Length in Older Men and Women.
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Kim, Eric S, Tindle, Hilary A, Kubzansky, Laura D, Liu, Simin, Duncan, Meredith S, Manson, JoAnn E, Springfield, Sparkle, Salmoirago-Blotcher, Elena, Shadyab, Aladdin H, Liu, Buyun, Grodstein, Francine, and De Vivo, Immaculata
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Biomedical and Clinical Sciences ,Clinical Sciences ,Mental Health ,Depression ,Prevention ,Aging ,Generic health relevance ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Cross-Sectional Studies ,Humans ,Leukocytes ,Middle Aged ,Optimism ,Telomere ,optimism ,psychological well-being ,telomere length ,aging ,HRS = Health and Retirement Study ,WHI = Women's Health Initiative ,CV = coefficient of variation ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology - Abstract
ObjectiveMounting evidence suggests that higher optimism is associated with reduced risk of age-related morbidities and premature mortality. However, possible biological mechanisms underlying these associations remain understudied. One hypothesized mechanism is a slower rate of cellular aging, which in turn delays age-related declines in health.MethodsWe used data from two large cohort studies to test the hypothesis that higher optimism is associated with longer leukocyte telomere length. With cross-sectional data from the Health and Retirement Study (HRS; n = 6417; mean age = 70 years) and the Women's Health Initiative (WHI; N = 3582; mean age = 63 years), we used linear regression models to examine the association of optimism with relative telomere length (assessed in leukocytes from saliva [HRS] or plasma [WHI]). Models adjusted for sociodemographics, depression, health status, and health behaviors.ResultsConsidering both optimism and telomere length as continuous variables, we found consistently null associations in both cohorts, regardless of which covariates were included in the models. In models adjusting for demographics, depression, comorbidities, and health behaviors, optimism was not associated with mean relative telomere length (HRS: β = -0.002, 95% confidence interval = -0.014 to 0.011; WHI: β = -0.004, 95% confidence interval = -0.017 to 0.009).ConclusionsFindings do not support mean telomere length as a mechanism that explains observed relations of optimism with reduced risk of chronic disease in older adults. Future research is needed to evaluate other potential biological markers and pathways.
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- 2020
116. Insulin Resistance and Cancer-Specific and All-Cause Mortality in Postmenopausal Women: The Women’s Health Initiative
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Pan, Kathy, Nelson, Rebecca A, Wactawski-Wende, Jean, Lee, Delphine J, Manson, JoAnn E, Aragaki, Aaron K, Mortimer, Joanne E, Phillips, Lawrence S, Rohan, Thomas, Ho, Gloria YF, Saquib, Nazmus, Shadyab, Aladdin H, Nassir, Rami, Rhee, Jinnie J, Hurria, Arti, and Chlebowski, Rowan T
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Prevention ,Aging ,Diabetes ,Nutrition ,Cancer ,Metabolic and endocrine ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Body Mass Index ,Cause of Death ,Female ,Follow-Up Studies ,Humans ,Insulin Resistance ,Middle Aged ,Neoplasms ,Postmenopause ,Proportional Hazards Models ,Public Health Surveillance ,Risk Factors ,United States ,Women's Health ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundInsulin resistance has been proposed as a mediator of the increased cancer incidence and mortality associated with obesity. However, prior studies included limited cancer deaths and had inconsistent findings. Therefore, we evaluated insulin resistance and cancer-specific and all-cause mortality in postmenopausal women participating in the Women's Health Initiative (WHI).MethodsEligible were a subsample of 22 837 WHI participants aged 50-79 years enrolled at 40 US clinical centers from 1993 to 1998 who had baseline fasting glucose and insulin levels. Baseline insulin resistance was measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Cancers were verified by central medical record review and deaths verified by medical record and death certificate review enhanced by National Death Index queries. Cox proportional hazards regression models were used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for cancer-specific and all-cause mortality. All statistical tests were two-sided.ResultsDuring a median of 18.9 years of follow-up, 1820 cancer deaths and 7415 total deaths occurred. Higher HOMA-IR quartile was associated with higher cancer-specific mortality (Q4 vs Q1, HR = 1.26, 95% CI = 1.09 to 1.47; Ptrend = .003) and all-cause mortality (Q4 vs Q1, HR = 1.63, 95% CI = 1.51 to 1.76; Ptrend < .001). A sensitivity analysis for diabetes status did not change findings. Among women with body mass index less than 25 kg/m2, higher HOMA-IR quartile was associated with higher cancer mortality (Fine and Gray, P = .004).ConclusionsHigh insulin resistance, as measured by HOMA-IR, identifies postmenopausal women at higher risk for cancer-specific and all-cause mortality who could potentially benefit from early intervention.
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- 2020
117. Exposure to fine particulate matter and temporal dynamics of episodic memory and depressive symptoms in older women
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Petkus, Andrew J, Younan, Diana, Widaman, Keith, Gatz, Margaret, Manson, JoAnn E, Wang, Xinhui, Serre, Marc, Vizuete, William, Chui, Helena, Espeland, Mark A, Resnick, Susan, and Chen, Jiu-Chiuan
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Acquired Cognitive Impairment ,Neurosciences ,Clinical Research ,Brain Disorders ,Aging ,Depression ,Dementia ,Mental Health ,Behavioral and Social Science ,Mental health ,Neurological ,Aged ,Aged ,80 and over ,Air Pollutants ,Environmental Exposure ,Female ,Humans ,Longitudinal Studies ,Memory ,Episodic ,Particulate Matter ,Particulate matter ,Depressive symptoms ,Episodic memory ,Structural equation modeling ,Environmental Sciences - Abstract
BackgroundEmerging data suggests PM2.5 (particulate matter with aerodynamic diameter
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- 2020
118. Low-fat dietary pattern and global cognitive function: Exploratory analyses of the Women's Health Initiative (WHI) randomized Dietary Modification trial.
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Chlebowski, Rowan T, Rapp, Steve, Aragaki, Aaron K, Pan, Kathy, Neuhouser, Marian L, Snetselaar, Linda G, Manson, JoAnn E, Wactawski-Wende, Jean, Johnson, Karen C, Hayden, Kathleen, Baker, Laura D, Henderson, Victor W, Garcia, Lorena, Qi, Lihong, and Prentice, Ross L
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Cognition ,Dietary modification ,Low-fat dietary pattern ,Randomized clinical trial ,Women's Health Initiative ,Womens Health Initiative - Abstract
Background:Meta-analyses of observational studies associate adherence to several dietary patterns with cognitive health. However, limited evidence from full scale, randomized controlled trials precludes causal inference regarding dietary effects on cognitive function. Methods:The Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, in 48,835 postmenopausal women, included a subset of 1,606 WHI Memory Study (WHIMS) participants >= 65 years old, to assess low-fat dietary pattern influence on global cognitive function, evaluated with annual screening (Modified Mini-Mental State Examinations [3MSE]). Participants were randomized by a computerized, permuted block algorithm, stratified by age group and center, to a dietary intervention (40%) to reduce fat intake to 20% of energy and increase fruit, vegetable and grain intake or usual diet comparison groups (60%). The study outcome was possible cognition impairment (failed cognitive function screening) through the 8.5 year (median) dietary intervention. Those failing screening received a comprehensive, multi-phase cognitive function assessment to classify as: no cognitive impairment, mild cognitive impairment, or probable dementia. Exploratory analyses examined the composite endpoint of death after possible cognitive impairment through 18.7 years (median) follow-up. The WHI trials are registered at ClinicalTrials.gov:NCT00000611. Findings:Among the 1,606 WHIMS participants, the dietary intervention statistically significantly reduced the incidence of possible cognitive impairment (n = 126; hazard ratio [HR] 0.59 95% confidence interval [CI] 0.38-0. 91, P = 0.01) with HR for dietary influence on subsequent mild cognitive impairment of 0.65 (95% CI 0.35-1.19) and HR of 0.63 (95% CI 0.19-2.10) for probable dementia (PD). Through 18.7 years, deaths from all-causes after possible cognitive impairment were non-significantly lower in the dietary intervention group (0.56% vs 0.77%, HR 0.83 95% CI 0.35 to 2.00, P = 0.16). Interpretation:Adoption of a low-fat eating pattern, representing dietary moderation, significantly reduced risk of possible cognitive impairment in postmenopausal women. Funding:Several Institutes of the US National Institutes of Health.
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- 2020
119. Association of Dietary Magnesium Intake with Fatal Coronary Heart Disease and Sudden Cardiac Death
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Li, Jason, Hovey, Kathleen M, Andrews, Christopher A, Quddus, Abdullah, Allison, Matthew A, Van Horn, Linda, Martin, Lisa W, Salmoirago-Blotcher, Elena, Song, Yiqing, Manson, JoAnn E, Albert, Christine M, Lu, Bing, and Eaton, Charles B
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Biomedical and Clinical Sciences ,Epidemiology ,Public Health ,Health Sciences ,Nutrition and Dietetics ,Cardiovascular ,Aging ,Heart Disease - Coronary Heart Disease ,Nutrition ,Clinical Research ,Prevention ,Heart Disease ,Aged ,Cohort Studies ,Coronary Disease ,Death ,Sudden ,Cardiac ,Female ,Humans ,Magnesium ,Middle Aged ,Nutritional Status ,Postmenopause ,Proportional Hazards Models ,Prospective Studies ,Risk Factors ,Risk Reduction Behavior ,Surveys and Questionnaires ,United States ,sudden cardiac death ,magnesium ,coronary heart disease ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Background: Postmenopausal women represent the highest population-based burden of cardiovascular disease, including sudden cardiac death (SCD). Our understanding of the etiology and risk factors contributing to fatal coronary heart disease (CHD) and SCD, particularly among women, is limited. This study examines the association between dietary magnesium intake and fatal CHD and SCD. Materials and Methods: We examined 153,569 postmenopausal women who participated in the Women's Health Initiative recruited between 1993 and 1998. Magnesium intake at baseline was assessed using a validated food frequency questionnaire, adjusting for energy via the residual method. Fatal CHD and SCD were identified over an average follow-up of 10.5 years. Results: For every standard deviation increase in magnesium intake, there was statistically significant risk reduction, after adjustment for confounders, of 7% for fatal CHD (hazard ratio [HR] 0.93, 95% confidence interval [CI] 0.89-0.97), and 18% risk reduction for SCD (HR 0.82, 95% CI 0.58-1.15) the latter of which did not reach statistical significance. In age-adjusted quartile analysis, women with the lowest magnesium intake (189 mg/day) had the greatest risk for fatal CHD (HR 1.54, 95% CI 1.40-1.69) and SCD (HR 1.70, 95% CI 0.94-3.07). This association was attenuated in the fully adjusted model, with HRs of 1.19 (95% CI 1.06-1.34) for CHD and 1.24 (95% CI 0.58-2.65) for SCD for the lowest quartile of magnesium intake. Conclusions: This study provides evidence of a potential inverse association between dietary magnesium and fatal CHD and a trend of magnesium with SCD in postmenopausal women. Future studies should confirm this association and consider clinical trials to test whether magnesium supplementation could reduce fatal CHD in high-risk individuals.
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- 2020
120. Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease.
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Younan, Diana, Petkus, Andrew J, Widaman, Keith F, Wang, Xinhui, Casanova, Ramon, Espeland, Mark A, Gatz, Margaret, Henderson, Victor W, Manson, JoAnn E, Rapp, Stephen R, Sachs, Bonnie C, Serre, Marc L, Gaussoin, Sarah A, Barnard, Ryan, Saldana, Santiago, Vizuete, William, Beavers, Daniel P, Salinas, Joel A, Chui, Helena C, Resnick, Susan M, Shumaker, Sally A, and Chen, Jiu-Chiuan
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Alzheimer’s disease ,air pollution ,episodic memory ,fine particulate matter ,neuroimaging ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Evidence suggests exposure to particulate matter with aerodynamic diameter
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- 2020
121. Cognitive resilience among APOE ε4 carriers in the oldest old
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Hayden, Kathleen M, Gaussoin, Sarah A, Hunter, Jaimie C, Manson, JoAnn E, Sachs, Bonnie C, Shadyab, Aladdin H, Tindle, Hilary A, Mossavar‐Rahmani, Yasmin, Mozhui, Khyobeni, Snively, Beverly M, Rapp, Stephen R, and Resnick, Susan M
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Health Services and Systems ,Health Sciences ,Aging ,Clinical Trials and Supportive Activities ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,Alzheimer's Disease ,Neurodegenerative ,Acquired Cognitive Impairment ,Prevention ,Clinical Research ,Cardiovascular ,Behavioral and Social Science ,Dementia ,Aged ,Aged ,80 and over ,Apolipoprotein E4 ,Cholesterol ,Cognition ,Cognition Disorders ,Female ,Health Status ,Humans ,Logistic Models ,Male ,Middle Aged ,Neuropsychological Tests ,Odds Ratio ,Resilience ,Psychological ,Risk Factors ,APOE epsilon ,cognitive resilience ,mild cognitive impairment ,oldest old ,probable dementia ,APOE ε ,Clinical Sciences ,Psychology ,Cognitive Sciences ,Geriatrics ,Clinical sciences ,Health services and systems ,Clinical and health psychology - Abstract
ObjectivesRelatively few APOE ε4+ carriers survive to old age (age 80+) without cognitive impairment (CI); thus, little is known about distinguishing characteristics of resilient APOE ε4+ carriers. Herein, we describe the sociodemographic characteristics of a large sample of resilient APOE ε4+ women from the Women's Health Initiative Memory Study (WHIMS) and compare them to noncarriers and APOE ε4+ women who developed CI before age 80.MethodsWomen were recruited for clinical trials evaluating postmenopausal hormone therapy and incidence of dementia. During posttrial follow-up, cognitive status was adjudicated annually. Among 5716 women, we compared groups by APOE ε4 status using logistic regression, covarying for treatment, demographics, lifestyle, cardiovascular and physical function, well-being, and self-rated general health.ResultsAmong 557 APOE ε4+ women, those who survived to age 80+ without CI had higher baseline self-rated general health (odds ratio [OR]: 1.02; 95% confidence interval [CI], 1.01-1.04) and cognitive scores (OR: 1.18; 95% CI, 1.12-1.25) than those who did not reach age 80 without CI. Baseline high total cholesterol and low-density lipoprotein (LDL) levels were similar across APOE ε4+ groups but were higher compared with APOE ε4- women. Among women who survived to 80+ without CI, more APOE ε4+ women had a history of high total cholesterol (P = .003) and LDL cholesterol (OR: 1.01; 95% CI, 1.00-1.01). There were no differences in hypertension, diabetes, or other vascular risk factors in APOE ε4+ women compared with noncarriers.ConclusionsResults highlight the importance of baseline cognitive function and general health for late-life cognition among ε4+ women.
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- 2019
122. Rare Genetic Variants Associated With Sudden Cardiac Death in Adults
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Khera, Amit V, Mason-Suares, Heather, Brockman, Deanna, Wang, Minxian, VanDenburgh, Martin J, Senol-Cosar, Ozlem, Patterson, Candace, Newton-Cheh, Christopher, Zekavat, Seyedeh M, Pester, Julie, Chasman, Daniel I, Kabrhel, Christopher, Jensen, Majken K, Manson, JoAnn E, Gaziano, J Michael, Taylor, Kent D, Sotoodehnia, Nona, Post, Wendy S, Rich, Stephen S, Rotter, Jerome I, Lander, Eric S, Rehm, Heidi L, Ng, Kenney, Philippakis, Anthony, Lebo, Matthew, Albert, Christine M, and Kathiresan, Sekar
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Biomedical and Clinical Sciences ,Clinical Sciences ,Prevention ,Genetics ,Clinical Research ,Heart Disease ,Cardiovascular ,4.2 Evaluation of markers and technologies ,Aetiology ,Detection ,screening and diagnosis ,2.4 Surveillance and distribution ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Case-Control Studies ,Death ,Sudden ,Cardiac ,Female ,Genetic Predisposition to Disease ,Humans ,Male ,Middle Aged ,Exome Sequencing ,gene sequencing ,genomic medicine ,sudden cardiac death ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundSudden cardiac death occurs in ∼220,000 U.S. adults annually, the majority of whom have no prior symptoms or cardiovascular diagnosis. Rare pathogenic DNA variants in any of 49 genes can pre-dispose to 4 important causes of sudden cardiac death: cardiomyopathy, coronary artery disease, inherited arrhythmia syndrome, and aortopathy or aortic dissection.ObjectivesThis study assessed the prevalence of rare pathogenic variants in sudden cardiac death cases versus controls, and the prevalence and clinical importance of such mutations in an asymptomatic adult population.MethodsThe authors performed whole-exome sequencing in a case-control cohort of 600 adult-onset sudden cardiac death cases and 600 matched controls from 106,098 participants of 6 prospective cohort studies. Observed DNA sequence variants in any of 49 genes with known association to cardiovascular disease were classified as pathogenic or likely pathogenic by a clinical laboratory geneticist blinded to case status. In an independent population of 4,525 asymptomatic adult participants of a prospective cohort study, the authors performed whole-genome sequencing and determined the prevalence of pathogenic or likely pathogenic variants and prospective association with cardiovascular death.ResultsAmong the 1,200 sudden cardiac death cases and controls, the authors identified 5,178 genetic variants and classified 14 as pathogenic or likely pathogenic. These 14 variants were present in 15 individuals, all of whom had experienced sudden cardiac death-corresponding to a pathogenic variant prevalence of 2.5% in cases and 0% in controls (p
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- 2019
123. Associations of parental ages at childbirth with healthy aging among women
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Shadyab, Aladdin H, Manson, JoAnn E, Li, Wenjun, Gass, Margery, Brunner, Robert L, Naughton, Michelle J, Cannell, Brad, Howard, Barbara V, and LaCroix, Andrea Z
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Aging ,Aetiology ,2.4 Surveillance and distribution ,Reproductive health and childbirth ,Good Health and Well Being ,Adult ,Aged ,Aged ,80 and over ,Cohort Studies ,Female ,Health Status ,Healthy Aging ,Humans ,Male ,Maternal Age ,Parturition ,Paternal Age ,Survival Rate ,Childbirth ,Longevity ,Maternal age ,Paternal age ,Women ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
OBJECTIVE:To examine associations of parental ages at childbirth with healthy survival to age 90 years among older women. STUDY DESIGN:This study included a racially and ethnically diverse sub-cohort of 8,983 postmenopausal women from the larger Women's Health Initiative population, recruited during 1993-1998 and followed for up to 25 years through 2018. MAIN OUTCOME MEASURES:The outcome was categorized as: 1) healthy survival, defined as survival to age 90 without major morbidities (coronary heart disease, stroke, diabetes, cancer, or hip fracture) or mobility disability; 2) usual survival, defined as survival to age 90 without healthy aging (reference category); or 3) death before age 90. Women reported their own and their parents' birth years, and parental ages at childbirth were calculated and categorized as
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- 2019
124. Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women’s Health Initiative Observational Study
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Trabert, Britton, Coburn, Sally B, Falk, Roni T, Manson, JoAnn E, Brinton, Louise A, Gass, Margery L, Kuller, Lewis H, Rohan, Thomas E, Pfeiffer, Ruth M, Qi, Lihong, Stefanick, Marcia L, Wentzensen, Nicolas, Anderson, Garnet L, and Xu, Xia
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Biomedical and Clinical Sciences ,Health Services and Systems ,Health Sciences ,Oncology and Carcinogenesis ,Reproductive Medicine ,Aging ,Cancer ,Rare Diseases ,Estrogen ,Prevention ,Clinical Research ,Ovarian Cancer ,Uterine Cancer ,Aged ,Endometrial Neoplasms ,Estradiol ,Estrogens ,Female ,Hormone Replacement Therapy ,Humans ,Middle Aged ,Ovarian Neoplasms ,Postmenopause ,Risk ,Endogenous estrogens ,Estrogen metabolites ,Ovarian cancer ,Endometrial cancer ,Nested case-control study ,Current hormone therapy users ,Nested case–control study ,Public Health and Health Services ,Epidemiology ,Oncology and carcinogenesis - Abstract
PurposeMenopausal hormone therapy (MHT) use induces alterations in circulating estrogens/estrogen metabolites, which may contribute to the altered risk of reproductive tract cancers among current users. Thus, the current study assessed associations between circulating estrogens/estrogen metabolites and ovarian and endometrial cancer risk among MHT users.MethodsWe conducted a nested case-control study among postmenopausal women using MHT at baseline in the Women's Health Initiative Observational Study (179 ovarian cancers, 396 controls; 230 endometrial cancers, 253 controls). Multivariable logistic regression was utilized to estimate odds ratios and 95% confidence intervals overall and by subtype.ResultsEstrogen/estrogen metabolite levels were not associated with overall or serous ovarian cancer risk, examined separately. However, unconjugated estradiol was positively associated with non-serous ovarian cancer risk [quintile 5 vs. quintile 1: 3.01 (1.17-7.73); p-trend = 0.03; p-het
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- 2019
125. Personality traits and the risk of coronary heart disease or stroke in women with diabetes - an epidemiological study based on the Women's Health Initiative.
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Miao Jonasson, Junmei, Hendryx, Michael, Manson, JoAnn E, Dinh, Paul, Garcia, Lorena, Liu, Simin, and Luo, Juhua
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Obstetrics & Reproductive Medicine ,Medical and Health Sciences - Abstract
OBJECTIVE:We studied the associations between personality traits and the risk of coronary heart disease (CHD) or stroke in women with diabetes. METHODS:From the Women's Health Initiative, 15,029 women aged 50 to 79 years at enrollment and with self-reported treated diabetes at baseline or follow-up, were followed for a mean of 10 years. Personality traits measured from validated scales included hostility, optimism, ambivalence over emotional expressiveness, and negative emotional expressiveness. Multivariable Cox proportional-hazards regression models were used to examine associations between personality traits and the risk of adjudicated CHD (nonfatal myocardial infarction and CHD death) or stroke outcomes. Progressively adjusted regression approach was used in the multivariable models to adjust for demographics, depression, anthropometric variables, and lifestyle factors. RESULTS:A total of 1,118 incident CHD and 710 incident stroke cases were observed. Women in the highest quartile of hostility had 22% (hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.01-1.48) increased risk for CHD compared with women in the lowest quartile of hostility. P values for trend were greater than 0.05. Stratified analysis by prevalent or incident diabetes showed that the highest quartile of hostility had 34% increased risk for CHD (HR 1.34, 95% CI 1.03-1.74) among women with incident diabetes. Other personality traits were not significantly associated with stroke or CHD. CONCLUSIONS:Hostility was associated with incidence of CHD among postmenopausal women with diabetes, especially among incident diabetes. These results provide a basis for targeted prevention programs for women with a high level of hostility and diabetes.
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- 2019
126. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis
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Marchand, Nathalie E., Choi, May Y., Oakes, Emily G., Cook, Nancy R., Stevens, Emma, Gomelskaya, Natalya, Kotler, Gregory, Manson, JoAnn E., Lasky-Su, Jessica, Mora, Samia, Lee, I-Min, Tatituri, Raju, and Costenbader, Karen H.
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- 2023
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127. Rationale and design of an ancillary study evaluating the effects of the cocoa flavanol and/or multivitamin interventions on falls and physical performance outcomes in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS)
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LeBoff, Meryl S., Chou, Sharon H., Ratliff, Kristin A., Cook, Nancy R., Clar, Allison, Holman, Beth, Copeland, Trisha, Smith, Doug C., Rist, Pamela M., Manson, JoAnn E., Sesso, Howard D., and Crandall, Carolyn J.
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- 2023
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128. Red meat consumption and all-cause and cardiovascular mortality: results from the UK Biobank study
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Wang, Mengying, Ma, Hao, Song, Qiying, Zhou, Tao, Hu, Yonghua, Heianza, Yoriko, Manson, JoAnn E., and Qi, Lu
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- 2022
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129. Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk
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Haring, Bernhard, Wissel, Stephanie, and Manson, JoAnn E.
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- 2022
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130. Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes
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Wang, Fenglei, Baden, Megu Y., Guasch-Ferré, Marta, Wittenbecher, Clemens, Li, Jun, Li, Yanping, Wan, Yi, Bhupathiraju, Shilpa N., Tobias, Deirdre K., Clish, Clary B., Mucci, Lorelei A., Eliassen, A. Heather, Costenbader, Karen H., Karlson, Elizabeth W., Ascherio, Alberto, Rimm, Eric B., Manson, JoAnn E., Liang, Liming, and Hu, Frank B.
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- 2022
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131. Breast cancer incidence and mortality by metabolic syndrome and obesity: The Women’s Health Initiative
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Chlebowski, Rowan T., primary, Aragaki, Aaron K., additional, Pan, Kathy, additional, Simon, Michael S., additional, Neuhouser, Marian L., additional, Haque, Reina, additional, Rohan, Thomas E., additional, Wactawski‐Wende, Jean, additional, Orchard, Tonya S., additional, Mortimer, Joanne E., additional, Lane, Dorothy, additional, Kaunitz, Andrew M., additional, Desai, Pinkal, additional, Wild, Robert A., additional, Barac, Ana, additional, and Manson, JoAnn E., additional
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- 2024
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132. Prediction of 24‐Hour Urinary Sodium Excretion Using Machine‐Learning Algorithms
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Hamaya, Rikuta, primary, Wang, Molin, additional, Juraschek, Stephen P., additional, Mukamal, Kenneth J., additional, Manson, JoAnn E., additional, Tobias, Deirdre K., additional, Sun, Qi, additional, Curhan, Gary C., additional, Willett, Walter C., additional, Rimm, Eric B., additional, and Cook, Nancy R., additional
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- 2024
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133. Low macular pigment optical density is associated with manifest primary open-angle glaucoma in older women
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Liu, Yao, primary, Lawler, Thomas, additional, Liu, Zhe, additional, Thuruthumaly, Catherine, additional, Vajaranant, Thasarat, additional, Wallace, Robert, additional, Tinker, Lesley, additional, Nalbandyan, Marine, additional, Mares, Julie, additional, Anderson, Garnet, additional, Prentice, Ross, additional, LaCroix, Andrea, additional, Kooperberg, Charles, additional, Blodi, Barbara, additional, Liu, Yao, additional, Domalpally, Amitha, additional, Engelman, Corinne, additional, Gangnon, Ronald, additional, Sarto, Gloria, additional, Bailey, Steven, additional, LeBlanc (Kaiser-Permanente), Erin, additional, Gehrs, Karen, additional, Robinson, Jennifer, additional, Snodderly, D. Max, additional, Hammond, Randy, additional, Millen, Amy, additional, Wooten, Bill, additional, Johnson, Elizabeth, additional, Jennifer Maykoski, B.S., additional, Lundquist, Ann, additional, Chris Smith, B.S., additional, Wood, Kim, additional, Perry-Raymond, Jennie, additional, Heather Stockman, B.S., additional, Walshire, Jean, additional, Sinkey, Christine, additional, Manson, JoAnn E., additional, Howard, Barbara V., additional, Stefanick, Marcia L., additional, Jackson, Rebecca, additional, Thomson, Cynthia A., additional, Wactawski-Wende, Jean, additional, Limacher, Marian, additional, Kuller, Lewis, additional, Shumaker, Sally, additional, Brunner, Robert, additional, Courtney Blomme, M.S., additional, Hall, Kristen, additional, Pauk, Diane, additional, Mezhibovsky, Esther, additional, Christensen, Krista, additional, Espeland, Mark, additional, Rossouw, Jacques, additional, Ludlam, Shari, additional, McGowan, Joan, additional, Ford, Leslie, additional, and Geller, Nancy, additional
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- 2024
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134. Identifying the relation between food groups and biological ageing: a data-driven approach
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Biemans, Ynte, primary, Bach, Daimy, additional, Behrouzi, Pariya, additional, Horvath, Steve, additional, Kramer, Charlotte S, additional, Liu, Simin, additional, Manson, JoAnn E, additional, Shadyab, Aladdin H, additional, Stewart, James, additional, Whitsel, Eric A, additional, Yang, Bo, additional, de Groot, Lisette, additional, and Grootswagers, Pol, additional
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- 2024
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135. The Women’s Health Initiative Randomized Trials and Clinical Practice
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Manson, JoAnn E., primary, Crandall, Carolyn J., additional, Rossouw, Jacques E., additional, Chlebowski, Rowan T., additional, Anderson, Garnet L., additional, Stefanick, Marcia L., additional, Aragaki, Aaron K., additional, Cauley, Jane A., additional, Wells, Gretchen L., additional, LaCroix, Andrea Z., additional, Thomson, Cynthia A., additional, Neuhouser, Marian L., additional, Van Horn, Linda, additional, Kooperberg, Charles, additional, Howard, Barbara V., additional, Tinker, Lesley F., additional, Wactawski-Wende, Jean, additional, Shumaker, Sally A., additional, and Prentice, Ross L., additional
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- 2024
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136. Advancing menopausal care: the importance of evidence on hormone therapy use and outcomes in women age 65 and older
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Iyer, Tara K., primary and Manson, JoAnn E., additional
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- 2024
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137. Ten-year changes in plasma L-carnitine levels and risk of coronary heart disease
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Heianza, Yoriko, Ma, Wenjie, DiDonato, Joseph A., Sun, Qi, Rimm, Eric B., Hu, Frank B., Rexrode, Kathryn M., Manson, JoAnn E., and Qi, Lu
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- 2022
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138. Breastfeeding duration and subsequent risk of mortality among US women: A prospective cohort study
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Wang, Yi-Xin, Arvizu, Mariel, Rich-Edwards, Janet W., Manson, JoAnn E., Wang, Liang, Missmer, Stacey A., and Chavarro, Jorge E.
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- 2022
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139. Serial 7-Day Electrocardiogram Patch Screening for AF in High-Risk Older Women by the CHARGE-AF Score
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Lin, Jeffrey Y., Larson, Joseph, Schoenberg, Jenny, Sepulveda, Alejandra, Tinker, Lesley, Wheeler, Matthew, Albert, Christine, Manson, JoAnn E., Wells, Gretchen, Martin, Lisa W., Froelicher, Victor, LaMonte, Mike, Kooperberg, Charles, Hlatky, Mark A., Greenland, Philip, Stefanick, Marcia L., and Perez, Marco V.
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- 2022
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140. Birth weight and long-term risk of mortality among US men and women: Results from three prospective cohort studies
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Wang, Yi-Xin, Ding, Ming, Li, Yanping, Wang, Liang, Rich-Edwards, Janet W., Florio, Andrea A., Manson, JoAnn E., and Chavarro, Jorge E.
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- 2022
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141. Vitamin D status, genetic factors, and risks of cardiovascular disease among individuals with type 2 diabetes: a prospective study
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Wan, Zhenzhen, Geng, Tingting, Li, Rui, Chen, Xue, Lu, Qi, Lin, Xiaoyu, Chen, Liangkai, Guo, Yanjun, Liu, Liegang, Shan, Zhilei, Pan, An, Manson, JoAnn E, and Liu, Gang
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- 2022
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142. Association between white matter hyperintensity volume and social functioning limitations among stroke survivors
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Chang, Flora G., Rost, Natalia S., Manson, JoAnn E., Buring, Julie E., and Rist, Pamela M.
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- 2022
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143. Association of neighborhood Walk Score with accelerometer-measured physical activity varies by neighborhood socioeconomic status in older women
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Seguin-Fowler, Rebecca A., LaCroix, Andrea Z., LaMonte, Michael J., Liu, Jingmin, Maddock, Jason E., Rethorst, Chad D., Bird, Chloe E., Stefanick, Marcia L., and Manson, JoAnn E.
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- 2022
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144. Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk from 5 Prospective Cohorts
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Lee, Alice A., Wang, Qiao-Li, Kim, Jihye, Babic, Ana, Zhang, Xuehong, Perez, Kimberly, Ng, Kimmie, Nowak, Jonathan, Rifazzzzzzzzgi, Nader, Sesso, Howard D., Buring, Julie E., Anderson, Garnet L., Wactawski-Wende, Jean, Wallace, Robert, Manson, JoAnn E., Giovannucci, Edward L., Stampfer, Meir J., Kraft, Peter, Fuchs, Charles S., Yuan, Chen, and Wolpin, Brian M.
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- 2023
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145. Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.
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Manson, JoAnn E, Aragaki, Aaron K, Bassuk, Shari S, Chlebowski, Rowan T, Anderson, Garnet L, Rossouw, Jacques E, Howard, Barbara V, Thomson, Cynthia A, Stefanick, Marcia L, Kaunitz, Andrew M, Crandall, Carolyn J, Eaton, Charles B, Henderson, Victor W, Liu, Simin, Luo, Juhua, Rohan, Thomas, Shadyab, Aladdin H, Wells, Gretchen, Wactawski-Wende, Jean, and Prentice, Ross L
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Sciences ,Aging ,Estrogen ,Clinical Trials and Supportive Activities ,Contraception/Reproduction ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Good Health and Well Being ,Age Factors ,Aged ,Breast Neoplasms ,Cause of Death ,Colorectal Neoplasms ,Coronary Disease ,Estrogen Replacement Therapy ,Estrogens ,Conjugated (USP) ,Female ,Follow-Up Studies ,Hip Fractures ,Humans ,Incidence ,Menopause ,Middle Aged ,Ovariectomy ,Pulmonary Embolism ,Stroke ,United States ,WHI Investigators ,Medical and Health Sciences ,General & Internal Medicine ,Clinical sciences - Abstract
BackgroundWhether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown.ObjectiveTo examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups.DesignSubgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT00000611).Setting40 U.S. clinical centers.Participants9939 women aged 50 to 79 years with prior hysterectomy and known oophorectomy status.InterventionConjugated equine estrogens (CEE) (0.625 mg/d) or placebo for a median of 7.2 years.MeasurementsIncidence of coronary heart disease and invasive breast cancer (the trial's 2 primary end points), all-cause mortality, and a "global index" (these end points plus stroke, pulmonary embolism, colorectal cancer, and hip fracture) during the intervention phase and 18-year cumulative follow-up.ResultsThe effects of CEE alone did not differ significantly according to BSO status. However, age modified the effect of CEE in women with prior BSO. During the intervention phase, CEE was significantly associated with a net adverse effect (hazard ratio for global index, 1.42 [95% CI, 1.09 to 1.86]) in older women (aged ≥70 years), but the global index was not elevated in younger women (P trend by age = 0.016). During cumulative follow-up, women aged 50 to 59 years with BSO had a treatment-associated reduction in all-cause mortality (hazard ratio, 0.68 [CI, 0.48 to 0.96]), whereas older women with BSO had no reduction (P trend by age = 0.034). There was no significant association between CEE and outcomes among women with conserved ovaries, regardless of age.LimitationsThe timing of CEE in relation to BSO varied; several comparisons were made without adjustment for multiple testing.ConclusionThe effects of CEE did not differ by BSO status in the overall cohort, but some findings varied by age. Among women with prior BSO, in those aged 70 years or older, CEE led to adverse effects during the treatment period, whereas women randomly assigned to CEE before age 60 seemed to derive mortality benefit over the long term.Primary funding sourceThe WHI program is funded by the National Heart, Lung, and Blood Institute; National Institutes of Health; and U.S. Department of Health and Human Services. Wyeth Ayerst donated the study drugs.
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- 2019
146. Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index
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Chen, Guo-Chong, Arthur, Rhonda, Iyengar, Neil M, Kamensky, Victor, Xue, Xiaonan, Wassertheil-Smoller, Sylvia, Allison, Matthew A, Shadyab, Aladdin H, Wild, Robert A, Sun, Yangbo, Banack, Hailey R, Chai, Jin Choul, Wactawski-Wende, Jean, Manson, JoAnn E, Stefanick, Marcia L, Dannenberg, Andrew J, Rohan, Thomas E, and Qi, Qibin
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Nutrition ,Brain Disorders ,Prevention ,Cardiovascular ,Obesity ,Aging ,Clinical Research ,Heart Disease ,Stroke ,Aged ,Body Fat Distribution ,Body Mass Index ,Cardiovascular Diseases ,Female ,Humans ,Middle Aged ,Postmenopause ,Prospective Studies ,Risk Assessment ,Risk Factors ,Body fat ,Normal-weight obesity ,Metabolically unhealthy normal weight ,Postmenopausal ,Cardiovascular disease ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
AIMS:Central adiposity is associated with increased cardiovascular disease (CVD) risk, even among people with normal body mass index (BMI). We tested the hypothesis that regional body fat deposits (trunk or leg fat) are associated with altered risk of CVD among postmenopausal women with normal BMI. METHODS AND RESULTS:We included 2683 postmenopausal women with normal BMI (18.5 to
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- 2019
147. The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
- Author
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Miller, Virginia M, Naftolin, Fredrick, Asthana, Sanjay, Black, Dennis M, Brinton, Eliot A, Budoff, Matthew J, Cedars, Marcelle I, Dowling, N Maritza, Gleason, Carey E, Hodis, Howard N, Jayachandran, Muthuvel, Kantarci, Kejal, Lobo, Rogerio A, Manson, JoAnn E, Pal, Lubna, Santoro, Nanette F, Taylor, Hugh S, and Harman, S Mitchell
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Aging ,Cardiovascular ,Estrogen ,Clinical Research ,Contraception/Reproduction ,Clinical Trials and Supportive Activities ,Prevention ,Women's Health ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Good Health and Well Being ,Carotid Intima-Media Thickness ,Coronary Artery Disease ,Estrogen Replacement Therapy ,Female ,Humans ,Menopause ,Middle Aged ,Randomized Controlled Trials as Topic ,Cardiovascular disease ,Cognition ,Hormone therapy ,Menopausal symptoms ,Menopause Osteoporosis ,Medical and Health Sciences ,Obstetrics & Reproductive Medicine ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
OBJECTIVE:The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address gaps in understanding the effects of timely menopausal hormone treatments (HT) on cardiovascular health and other effects of menopause after the premature termination of the Women's Health Initiative. METHOD:The KEEPS was a randomized, double-blinded, placebo-controlled trial to test the hypothesis that initiation of HT (oral conjugated equine estrogens [o-CEE] or transdermal 17β-estradiol [t-E2]) in healthy, recently postmenopausal women (n = 727) would slow the progression of atherosclerosis as measured by changes in carotid artery intima-media thickness (CIMT). RESULTS:After 4 years, neither HT affected the rate of increase in CIMT. There was a trend for reduced accumulation of coronary artery calcium with o-CEE. There were no severe adverse effects, including venous thrombosis. Several ancillary studies demonstrated a positive effect on mood with o-CEE, and reduced hot flashes, improved sleep, and maintenance of bone mineral density with both treatments. Sexual function improved with t-E2. There were no significant effects of either treatment on cognition, breast pain, or skin wrinkling. Variants of genes associated with estrogen metabolism influenced the age of menopause and variability in effects of the HT on CIMT. Platelet activation associated with the development of white matter hyperintensities in the brain. CONCLUSIONS:KEEPS and its ancillary studies have supported the value and safety of the use of HT in recently postmenopausal women and provide a perspective for future research to optimize HT and health of postmenopausal women. The KEEPS continuation study continues to pursue these issues.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0.
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- 2019
148. Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial
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Khoudary, Samar R El, Zhao, Qian, Venugopal, Vidya, Manson, JoAnn E, Brooks, Maria M, Santoro, Nanette, Black, Dennis M, Harman, S Mitchell, Cedars, Marcelle I, Hopkins, Paul N, Kearns, Ann E, Miller, Virginia M, Taylor, Hugh S, and Budoff, Matthew J
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Heart Disease ,Prevention ,Clinical Research ,Clinical Trials and Supportive Activities ,Heart Disease - Coronary Heart Disease ,Estrogen ,Cardiovascular ,Aging ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adipose Tissue ,Coronary Artery Disease ,Disease Progression ,Estradiol ,Estrogen Replacement Therapy ,Estrogens ,Estrogens ,Conjugated (USP) ,Female ,Humans ,Middle Aged ,Pericardium ,Vascular Calcification ,coronary artery disease ,epicardial fat ,estrogen ,menopause ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Background Heart fats (epicardial and paracardial adipose tissue [PAT]) are greater after menopause. Endogenous estrogen may regulate these fat depots. We evaluated the differential effects of hormone therapy formulations on heart fat accumulations and their associations with coronary artery calcification (CAC) progression in recently menopausal women from KEEPS (Kronos Early Estrogen Prevention Study). Methods and Results KEEPS was a multicenter, randomized, placebo-controlled trial of the effects of 0.45 mg/d oral conjugated equine estrogens and 50 µg/d transdermal 17β-estradiol, compared with placebo, on 48-month progression of subclinical atherosclerosis among 727 early menopausal women. CAC progression was defined if baseline CAC score was 0 and 48-month CAC score was >0 or if baseline CAC score was >0 and
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- 2019
149. Effects of Hormone Therapy on Heart Fat and Coronary Artery Calcification Progression: Secondary Analysis From the KEEPS Trial.
- Author
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El Khoudary, Samar R, Zhao, Qian, Venugopal, Vidya, Manson, JoAnn E, Brooks, Maria M, Santoro, Nanette, Black, Dennis M, Harman, S Mitchell, Cedars, Marcelle I, Hopkins, Paul N, Kearns, Ann E, Miller, Virginia M, Taylor, Hugh S, and Budoff, Matthew J
- Subjects
Pericardium ,Adipose Tissue ,Humans ,Disease Progression ,Estradiol ,Estrogens ,Conjugated (USP) ,Estrogens ,Estrogen Replacement Therapy ,Middle Aged ,Female ,Coronary Artery Disease ,Vascular Calcification ,coronary artery disease ,epicardial fat ,estrogen ,menopause ,Conjugated ,Cardiorespiratory Medicine and Haematology - Abstract
Background Heart fats (epicardial and paracardial adipose tissue [PAT]) are greater after menopause. Endogenous estrogen may regulate these fat depots. We evaluated the differential effects of hormone therapy formulations on heart fat accumulations and their associations with coronary artery calcification (CAC) progression in recently menopausal women from KEEPS (Kronos Early Estrogen Prevention Study). Methods and Results KEEPS was a multicenter, randomized, placebo-controlled trial of the effects of 0.45 mg/d oral conjugated equine estrogens and 50 µg/d transdermal 17β-estradiol, compared with placebo, on 48-month progression of subclinical atherosclerosis among 727 early menopausal women. CAC progression was defined if baseline CAC score was 0 and 48-month CAC score was >0 or if baseline CAC score was >0 and
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- 2019
150. Plasma Phospholipid Fatty Acids and Coronary Heart Disease Risk: A Matched Case-Control Study within the Women's Health Initiative Observational Study.
- Author
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Liu, Qing, Matthan, Nirupa R, Manson, JoAnn E, Howard, Barbara V, Tinker, Lesley F, Neuhouser, Marian L, Van Horn, Linda V, Rossouw, Jacques E, Allison, Matthew A, Martin, Lisa W, Li, Wenjun, Snetselaar, Linda G, Wang, Lu, Lichtenstein, Alice H, and Eaton, Charles B
- Subjects
Humans ,Coronary Disease ,Phospholipids ,Body Mass Index ,Risk Factors ,Case-Control Studies ,Aged ,Middle Aged ,Female ,Hyperlipidemias ,coronary heart disease ,plasma phospholipid fatty acids ,postmenopausal women ,Food Sciences ,Nutrition and Dietetics - Abstract
Background and aimsThe association of fatty acids with coronary heart disease (CHD) has been examined, mainly through dietary measurements, and has generated inconsistent results due to measurement error. Large observational studies and randomized controlled trials have shown that plasma phospholipid fatty acids (PL-FA), especially those less likely to be endogenously synthesized, are good biomarkers of dietary fatty acids. Thus, PL-FA profiles may better predict CHD risk with less measurement error.MethodsWe performed a matched case-control study of 2428 postmenopausal women nested in the Women's Health Initiative Observational Study. Plasma PL-FA were measured using gas chromatography and expressed as molar percentage (moL %). Multivariable conditional logistic regression was used to calculate odds ratios (95% CIs) for CHD associated with 1 moL % change in PL-FA.ResultsHigher plasma PL long-chain saturated fatty acids (SFA) were associated with increased CHD risk, while higher n-3 polyunsaturated fatty acids (PUFA) were associated with decreased risk. No significant associations were observed for very-long-chain SFA, monounsaturated fatty acids (MUFA), PUFA n-6 or trans fatty acids (TFA). Substituting 1 moL % PUFA n-6 or TFA with an equivalent proportion of PUFA n-3 were associated with lower CHD risk.ConclusionsHigher plasma PL long-chain SFA and lower PUFA n-3 were associated with increased CHD risk. A change in diet by limiting foods that are associated with plasma PL long-chain SFA and TFA while enhancing foods high in PUFA n-3 may be beneficial in CHD among postmenopausal women.
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- 2019
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