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109. Earlier diagnosis of peripheral neuropathy in primary care: A call to action.

Author

Gad, Hoda, Kalra, Sanjay, Pinzon, Rizaldy, Gracia, Rey‐an Nino, Yotsombut, Kitiyot, Coetzee, Ankia, Nafach, Jalal, Lim, Lee‐Ling, Fletcher, Pablo E., Lim, Vivien, and Malik, Rayaz A.

Subjects
PERIPHERAL neuropathy diagnosis, PRIMARY health care, QUESTIONNAIRES, EARLY diagnosis, RESOURCE-limited settings
Abstract

Peripheral neuropathy (PN) often remains undiagnosed (~80%). Earlier diagnosis of PN may reduce morbidity and enable earlier risk factor reduction to limit disease progression. Diabetic peripheral neuropathy (DPN) is the most common PN and the 10 g monofilament is endorsed as an inexpensive and easily performed test for DPN. However, it only detects patients with advanced neuropathy at high risk of foot ulceration. There are many validated questionnaires to diagnose PN, but they can be time‐consuming and have complex scoring systems. Primary care physicians (PCPs) have busy clinics and lack access to a readily available screening method to diagnose PN. They would prefer a short, simple, and accurate tool to screen for PN. Involving the patient in the screening process would not only reduce the time a physician requires to make a diagnosis but would also empower the patient. Following an expert meeting of diabetologists and neurologists from the Middle East, South East Asia and Latin America, a consensus was formulated to help improve the diagnosis of PN in primary care using a simple tool for patients to screen themselves for PN followed by a consultation with the physician to confirm the diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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111. Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria

Author

Freeman, Roy, Gewandter, Jennifer S., Faber, Catharina G., Gibbons, Christopher, Haroutounian, Simon, Lauria, Giuseppe, Levine, Todd, Malik, Rayaz A., Singleton, J. Robinson, Smith, A. Gordon, Bell, Josh, Dworkin, Robert H., Feldman, Eva, Herrmann, David N., Hoke, Ahmet, Kolb, Noah, Mansikka, Heikki, Oaklander, Anne Louise, Peltier, Amanda, Polydefkis, Michael, Ritt, Elissa, Russell, James W., Sainati, Stephen, Steiner, Deborah, Treister, Roi, and Üçeyler, Nurcan

Published
2020
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117. Corneal confocal microscopy for identification of diabetic sensorimotor polyneuropathy: a pooled multinational consortium study

Author

Perkins, Bruce A., Lovblom, Leif E., Bril, Vera, Scarr, Daniel, Ostrovski, Ilia, Orszag, Andrej, Edwards, Katie, Pritchard, Nicola, Russell, Anthony, Dehghani, Cirous, Pacaud, Danièle, Romanchuk, Kenneth, Mah, Jean K., Jeziorska, Maria, Marshall, Andrew, Shtein, Roni M., Pop-Busui, Rodica, Lentz, Stephen I., Boulton, Andrew J. M., Tavakoli, Mitra, Efron, Nathan, and Malik, Rayaz A.

Published
2018
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119. Blood-Based Proteomic Profiling Identifies Potential Biomarker Candidates and Pathogenic Pathways in Dementia

Author

Ehtewish, Hanan, primary, Mesleh, Areej, additional, Ponirakis, Georgios, additional, De la Fuente, Alberto, additional, Parray, Aijaz, additional, Bensmail, Ilham, additional, Abdesselem, Houari, additional, Ramadan, Marwan, additional, Khan, Shafi, additional, Chandran, Mani, additional, Ayadathil, Raheem, additional, Elsotouhy, Ahmed, additional, Own, Ahmed, additional, Al Hamad, Hanadi, additional, Abdelalim, Essam M., additional, Decock, Julie, additional, Alajez, Nehad M., additional, Albagha, Omar, additional, Thornalley, Paul J., additional, Arredouani, Abdelilah, additional, Malik, Rayaz A., additional, and El-Agnaf, Omar M. A., additional

Published
2023
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122. TRPA1 rare variants in chronic neuropathic and nociplastic pain patients

Author

Marchi, Margherita, primary, Salvi, Erika, additional, Andelic, Mirna, additional, Mehmeti, Elkadia, additional, D'Amato, Ilaria, additional, Cazzato, Daniele, additional, Chiappori, Federica, additional, Lombardi, Raffaella, additional, Cartelli, Daniele, additional, Devigili, Grazia, additional, Dalla Bella, Eleonora, additional, Gerrits, Monique, additional, Almomani, Rowida, additional, Malik, Rayaz A., additional, Ślęczkowska, Milena, additional, Mazzeo, Anna, additional, Gentile, Luca, additional, Dib-Hajj, Sulayman, additional, Waxman, Stephen G., additional, Faber, Catharina G., additional, Vecchio, Eleonora, additional, de Tommaso, Marina, additional, and Lauria, Giuseppe, additional

Published
2023
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123. Prevalence of Diabetes and Cardiovascular Risk in the Middle East and Africa: Primary Results of the PACT-MEA Study

Author

Verma, Subodh, primary, Alamuddin, Naji, additional, Alawadi, Fatheya, additional, Alkandari, Hessa, additional, Almahmeed, Wael, additional, Assaad-Khalil, Samir H., additional, Haddad, Jihad, additional, Husemoen, Lise Lotte N., additional, Lombard, Landman, additional, Malik, Rayaz A., additional, Mashaki Ceyhan, Emel, additional, Sabbour, Hani, additional, Tombak, Gamze, additional, Yadav, Gourav, additional, and Salek, Sam, additional

Published
2023
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131. Laser-Induced Graphene-Based Smart Insole to Measure Plantar Temperature

Author

Khandakar, Amith, Faisal, Md. Ahasan Atick, Chowdhury, Muhammad E. H., Reaz, Mamun Bin Ibne, Ali, Sawal Hamid Md, Razak, Mohd Ibrahim bin Shapiai Abd., Bakar, Ahmad Ashrif A., Mahmud, Sakib, and Malik, Rayaz A.

Abstract

Diabetic foot ulceration (DFU) could potentially be avoided by continuously monitoring plantar (foot sole) temperature at home to alert the onset of tissue breakdown. Systems, which can measure plantar temperature in real-time, have limited availability and are relatively expensive. We report on the synthesis, design, characterization, and implementation of a laser-induced graphene (LIG) based smart insole capable of measuring plantar temperature and pressure continuously and generating and storing the plantar temperature maps. Our proposed solution is lightweight, cheaper, and comparable in sensitivity, Limit of Detection, Range of Detection, Response Time, and Recovery time to other available solutions. This is the first study to utilize LIG in insoles to generate temperature maps that effectively identify patients with severe DSPN and those at high risk of DFU.

Published
2024
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135. Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation.

Author

Oh, Jiwon, Airas, Laura, Harrison, Daniel, Järvinen, Elina, Livingston, Terrie, Lanker, Stefan, Malik, Rayaz A., Okuda, Darin T., Villoslada, Pablo, and de Vries, Helga E.

Subjects
MULTIPLE sclerosis, POSITRON emission tomography, PATHOLOGY, MAGNETIC resonance imaging, BRAIN imaging
Abstract

Key unmet needs in multiple sclerosis (MS) include detection of early pathology, disability worsening independent of relapses, and accurate monitoring of treatment response. Collaborative approaches to address these unmet needs have been driven in part by industry–academic networks and initiatives such as the Grant for Multiple Sclerosis Innovation (GMSI) and Multiple Sclerosis Leadership and Innovation Network (MS-LINK™) programs. We review the application of recent advances, supported by the GMSI and MS-LINK™ programs, in neuroimaging technology to quantify pathology related to central pathology and disease worsening, and potential for their translation into clinical practice/trials. GMSI-supported advances in neuroimaging methods and biomarkers include developments in magnetic resonance imaging, positron emission tomography, ocular imaging, and machine learning. However, longitudinal studies are required to facilitate translation of these measures to the clinic and to justify their inclusion as endpoints in clinical trials of new therapeutics for MS. Novel neuroimaging measures and other biomarkers, combined with artificial intelligence, may enable accurate prediction and monitoring of MS worsening in the clinic, and may also be used as endpoints in clinical trials of new therapies for MS targeting relapseindependent disease pathology [ABSTRACT FROM AUTHOR]

Published
2023
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136. Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia.

Author

Ehtewish, Hanan, Mesleh, Areej, Ponirakis, Georgios, Lennard, Katie, Al Hamad, Hanadi, Chandran, Mani, Parray, Aijaz, Abdesselem, Houari, Wijten, Patrick, Decock, Julie, Alajez, Nehad M., Ramadan, Marwan, Khan, Shafi, Ayadathil, Raheem, Own, Ahmed, Elsotouhy, Ahmed, Albagha, Omar, Arredouani, Abdelilah, Blackburn, Jonathan M., and Malik, Rayaz A.

Subjects
MILD cognitive impairment, AUTOANTIBODIES, AUTOIMMUNE diseases, DEMENTIA, LONG-term potentiation, NEUROLOGICAL disorders
Abstract

Background: Dementia is a debilitating neurological disease affecting millions of people worldwide. The exact mechanisms underlying the initiation and progression of the disease remain to be fully defined. There is an increasing body of evidence for the role of immune dysregulation in the pathogenesis of dementia, where blood-borne autoimmune antibodies have been studied as potential markers associated with pathological mechanisms of dementia. Methods: This study included plasma from 50 cognitively normal individuals, 55 subjects with MCI (mild cognitive impairment), and 22 subjects with dementia. Autoantibody profiling for more than 1,600 antigens was performed using a high throughput microarray platform to identify differentially expressed autoantibodies in MCI and dementia. Results: The differential expression analysis identified 33 significantly altered autoantibodies in the plasma of patients with dementia compared to cognitively normal subjects, and 38 significantly altered autoantibodies in the plasma of patients with dementia compared to subjects with MCI. And 20 proteins had significantly altered autoantibody responses in MCI compared to cognitively normal individuals. Five autoantibodies were commonly dysregulated in both dementia and MCI, including anti-CAMK2A, CKS1B, ETS2, MAP4, and NUDT2. Plasma levels of anti-ODF3, E6, S100P, and ARHGDIG correlated negatively with the cognitive performance scores (MoCA) (r 2 –0.56 to −0.42, value of p <  0.001). Additionally, several proteins targeted by autoantibodies dysregulated in dementia were significantly enriched in the neurotrophin signaling pathway, axon guidance, cholinergic synapse, long-term potentiation, apoptosis, glycolysis and gluconeogenesis. Conclusion: We have shown multiple dysregulated autoantibodies in the plasma of subjects with MCI and dementia. The corresponding proteins for these autoantibodies are involved in neurodegenerative pathways, suggesting a potential impact of autoimmunity on the etiology of dementia and the possible benefit for future therapeutic approaches. Further investigations are warranted to validate our findings. [ABSTRACT FROM AUTHOR]

Published
2023
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137. Microvascular complications of obesity and diabetes—Role of bariatric surgery.

Author

Bashir, Bilal, Iqbal, Zohaib, Adam, Safwaan, Ferdousi, Maryam, Chick, William, Hussein, Heleen A., Syed, Akheel A., Le Roux, Carel W., Cohen, Ricardo V., Malik, Rayaz A., and Soran, Handrean

Subjects
GASTRIC bypass, BARIATRIC surgery, DIABETES complications, OBESITY complications, TYPE 2 diabetes, SURGICAL complications
Abstract

Summary: Bariatric surgery in people with obesity can lead to long‐term remission of type 2 diabetes mellitus (T2DM) and a reduction in the incidence of macrovascular complications. The impact of bariatric surgery on microvascular complications is less clear. In this narrative review, we sought to evaluate the effect of bariatric surgery on microvascular complications in patients with and without diabetes. The risk of developing microvascular complications is increased in people with obesity, and this is amplified in those with T2DM. The impact of metabolic surgery on microvascular complications is limited to a subgroup analysis of studies or statistical modeling to predict the glycemia‐independent effect of bariatric surgery. While bariatric surgery halts the progression of retinopathy in those with minimal retinopathy, it may worsen in those with advanced retinopathy. Bariatric surgery improves proteinuria and major renal outcomes, regardless of the severity of renal impairment. Bariatric surgery in patients with obesity with or without diabetes is associated with an improvement in neuropathic symptoms and regeneration of small nerve fibers. In conclusion, bariatric surgery is associated with an improvement in microvascular complications. Further studies are needed to elucidate the underlying mechanisms for the favorable effect of bariatric surgery on microvascular outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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138. A randomized clinical trial of glenohumeral joint steroid injection versus suprascapular nerve block in patients with frozen shoulder: a protocol for the Therapeutic Injections For Frozen Shoulder (TIFFS) study

Author

Jump, Christopher M., primary, Mati, Wael, additional, Maley, Alex, additional, Taylor, Rebecca, additional, Gratrix, Karen, additional, Blundell, Clare, additional, Lane, Suzanne, additional, Solanki, Nilesh, additional, Khan, Maqsood, additional, Choudhry, Muhammad, additional, Shetty, Vishwanath, additional, Malik, Rayaz A., additional, and Charalambous, Charalambos P., additional

Published
2023
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140. A cross‐sectional study of the prevalence and clinical management of atherosclerotic cardiovascular diseases in patients with type 2 diabetes across the Middle East and Africa ( PACT‐MEA ): Study design and rationale

Author

Verma, Subodh, primary, Sabbour, Hani, additional, Alamuddin, Naji, additional, Alawadi, Fatheya, additional, Alkandari, Hessa, additional, Almahmeed, Wael, additional, Assaad‐Khalil, Samir H., additional, Haddad, Jihad, additional, Lombard, Landman, additional, Malik, Rayaz A., additional, Mashaki Ceyhan, Emel, additional, Prasad, Preethy, additional, Tombak, Gamze, additional, and Salek, Sam, additional

Published
2023
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141. PREVALENCE OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASES IN PATIENTS WITH TYPE 2 DIABETES ACROSS MIDDLE EAST AND AFRICA: PRIMARY RESULTS OF THE PACT-MEA STUDY

Author

Verma, Subodh, primary, Alamuddin, Naji, additional, Alawadi, Fatheya, additional, Alkandari, Hessa, additional, Almahmeed, Wael A., additional, Assaad-Khalil, Samir, additional, Haddad, Jihad, additional, Husemoen, Lise Lotte Nystrup, additional, Lombard, Landman, additional, Malik, Rayaz Ahmed, additional, Ceyhan, Emel Mashaki, additional, Sabbour, Hani, additional, Yadav, Gourav, additional, and Verma, Subodh, additional

Published
2023
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142. Corneal nerve loss predicts dementia in patients with mild cognitive impairment

Author

Ponirakis, Georgios, primary, Al Hamad, Hanadi, additional, Omar, Dunya A. M., additional, Petropoulos, Ioannis N., additional, Khan, Adnan, additional, Gad, Hoda, additional, Chandran, Mani, additional, Gadelseed, Masharig, additional, Elsotouhy, Ahmed, additional, Ramadan, Marwan, additional, Gawhale, Priya V., additional, Elorrabi, Marwa, additional, Tosino, Rhia, additional, Mahfoud, Ziyad R., additional, Khan, Shafi, additional, Manikoth, Pravija, additional, Abdelrahim, Yasmin H. M., additional, Refaee, Mahmoud A., additional, Thodi, Noushad, additional, Own, Ahmed, additional, Shuaib, Ashfaq, additional, and Malik, Rayaz A., additional

Published
2023
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143. Diagnostic Accuracy of Perception Threshold Tracking in the Detection of Small Fiber Damage in Type 1 Diabetes

Author

Røikjer, Johan, primary, Croosu, Suganthiya Santhiapillai, additional, Sejergaard, Benn Falch, additional, Hansen, Tine Maria, additional, Frøkjær, Jens Brøndum, additional, Søndergaard, Chris Bath, additional, Petropoulos, Ioannis N., additional, Malik, Rayaz A., additional, Nielsen, Esben, additional, Mørch, Carsten Dahl, additional, and Ejskjaer, Niels, additional

Published
2023
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145. A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument

Author

Haque, Fahmida, primary, Reaz, Mamun B. I., additional, Chowdhury, Muhammad E. H., additional, Shapiai, Mohd Ibrahim bin, additional, Malik, Rayaz A., additional, Alhatou, Mohammed, additional, Kobashi, Syoji, additional, Ara, Iffat, additional, Ali, Sawal H. M., additional, Bakar, Ahmad A. A., additional, and Bhuiyan, Mohammad Arif Sobhan, additional

Published
2023
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146. Corneal Confocal Microscopy Based Deep Learning Algorithms Demonstrate Excellent Diagnostic Accuracy in Identifying Patients with Dementia, Multiple Sclerosis and Parkinson's Disease

Author

Meng, Yanda, primary, Anson, Matthew, additional, Preston, Frank, additional, Burgess, Jamie, additional, Ferdousi, Maryam, additional, Silverdale, Monty, additional, Kobylecki, Christopher, additional, Hway Lim, Sze, additional, Petropoulos, Ioannis N., additional, Ponirakis, Georgios, additional, Gad, Hoda, additional, Khan, Adnan, additional, Kamran, Saadat, additional, Akhtar, Naveed, additional, Shuaib, Ashfaq, additional, Al Hamad, Hanadi, additional, Chandran, Mani, additional, Malik, Rayaz A., additional, Zheng, Yalin, additional, and Alam, Uazman, additional

Published
2023
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148. DSPNet: A Self-ONN Model for Robust DSPN Diagnosis from Temperature Maps

Author

Khandakar, Amith, primary, Chowdhury, Muhammad E. H., additional, Reaz, Mamun Bin Ibne, additional, Kiranyaz, Serkan, additional, Hasan, Md Anwarul, additional, Rahman, Tawsifur, additional, Ali, Sawal Hamid Md, additional, Razak, Mohd Ibrahim bin Shapiai Abd, additional, Bakar, Ahmad Ashrif A., additional, Podder, Kanchon Kanti, additional, Chowdhury, Moajjem Hossain, additional, Faisal, Md Ahasan Atick, additional, and Malik, Rayaz A., additional

Published
2023
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150. Vascular Risk Factor Reduction is Associated with Corneal Nerve Regeneration in Patients with TIA and Ischemic Stroke

Author

Khan, Adnan, primary, Akhtar, Naveed, additional, Faisal Wadiwala, Muhammad, additional, Al Qurashi, Albandary, additional, Al Khawaja, Fatima, additional, Gad, Hoda, additional, Ponirakis, Georgios, additional, Petropoulos, Ioannis N., additional, Mahfoud, Ziyad, additional, Saqqur, Maher, additional, Shuaib, Ashfaq, additional, and Malik, Rayaz A., additional

Published
2023
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