348 results on '"Maleki H"'
Search Results
102. Production of Heart Valves from Glassy Polymeric Carbon
- Author
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Jenkins, G. M., primary, Ila, D., additional, and Maleki, H., additional
- Published
- 1995
- Full Text
- View/download PDF
103. A Carbon Drug Delivery System for Lithium
- Author
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Maleki, H., primary, Ila, D., additional, Zimmerman, R. L., additional, Jenkins, G. M., additional, and Poker, D., additional
- Published
- 1995
- Full Text
- View/download PDF
104. Process Dependence of Orientation of Ribbon-Like Aromatic Molecules in Glassy Carbon
- Author
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Maleki, H., primary, Ila, D., additional, Holland, L. R., additional, Zimmerman, R. L., additional, and Jenkins, G. M., additional
- Published
- 1994
- Full Text
- View/download PDF
105. Pattern of Medical Ethics Curriculum with Islamic Approach.
- Author
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Khaghanizade, M., Maleki, H., Abbasi, M., and Abbaspour, A.
- Subjects
MEDICAL ethics ,ISLAMIC ethics ,MEDICAL publishing ,MEDICAL literature reviews ,CRITICISM ,CONTENT analysis ,CURRICULUM planning - Abstract
Aims Extensive research has been done to promote the medical ethics curriculum and several useful reviews and criticism have been published in this regard. However, no curriculum which is proportionate to our country's cultural and religious characteristics has been designed yet. So, the aim of this study was to design an appropriate and comprehensive pattern for medical ethics curriculum relying on Islam's ethics and value principles. Methods In this qualitative study, qualitative content analysis was used to examine the status of medical ethics education in Iran. Data was obtained using individual structured interview with 14 medical ethics authorities. In order to explain the elements and structure of the medical ethics curriculum in the international experiences, systematic review was used and 18 articles from the valid databases were analyzed. Using the library research, the evidence available in the reliable Islamic texts was gathered. Results The designed pattern had a combinative approach toward the medical ethics curriculum elements. The most significant and the first level of the present pattern were Islamic basics and principles and in the higher level were the principles derived from these basics and essentials. Islamic principles and essentials directed the purposes of the present pattern and turned out to be like a filter to prevent the entrance of the elements inconsistent with Islamic values into the medical ethics curriculum. Conclusion It is possible to achieve the ethical education and learning of skills and qualifications of medical ethics in light of medical ethics curriculum principles and essentials with an Islamic approach and considering the elements of the formal curriculum and implicit curriculum according to the goals of this pattern. [ABSTRACT FROM AUTHOR]
- Published
- 2013
106. A novel honey-based nanofibrous scaffold for wound dressing application.
- Author
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Maleki, H., Gharehaghaji, A. A., and Dijkstra, P. J.
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POLYVINYL alcohol ,HONEY ,ELECTROSPINNING ,FIBROUS composites ,NANOFIBERS ,ANTI-inflammatory agents ,ANTIBIOTICS ,DRUG delivery systems ,MIXTURES - Abstract
In this study, nanofiber meshes were produced from aqueous mixtures of poly(vinyl alcohol) (PVA) and honey via electrospinning. The Electrospinning process was performed at different PVAs to honey ratios (100/0, 90/10, 80/20, 70/30, and 60/40). Dexamethasone sodium phosphate was selected as an anti-inflammatory drug and incorporated in the electrospinning solutions. Its release behavior was determined. Uniform and smooth nanofibers were formed, independent of the honey content. In case honey content increased up to 40%, some spindle-like beads on the fibers were observed. The diameter of electrospun fibers decreased as the ratio of honey increased. The release characteristics of the model drug from both the PVA and PVA/honey (80/20) nanofibrous mats were studied and statistical analysis was performed. All electrospun fibers exhibited a large initial burst release at a short time after incubation. The release profile was similar for both PVA and PVA/honey (80/20) drug-loaded nanofibers. This study shows that an anti-inflammatory drug can be released during the initial stages and honey can be used as a natural antibiotic to improve the wound dressing efficiency and increase the healing rate. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci, 2013 [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
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107. Role of self-evaluation in educational and learning process of students.
- Author
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Zareei, H., Maleki, H., and Sabzi Pour, A.
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SELF-evaluation ,STUDENTS ,LEARNING ,CLASSROOMS ,SCHOOL failure ,ACADEMIC achievement ,EDUCATIONAL objectives ,PERFORMANCE evaluation - Abstract
Introduction: Classroom should be an opportunity of repeating the action for learner, because learners pursue his/her unknowing and undoubtedly, in this way will face with successes and failures but the most important issue is that learners understand the value of knowing what he/she doesn't know. In this case, students compensate their failures and learn how to evaluate and improve their performance. The goal of this study was to analyze the role of self-evaluation in the process of education and learning. Conclusion: Increasing the learners' participation through their interference in actions is the transcendence of education and challenging the present situation and make changes due to innovation and creating learning opportunities is the transcendence of evaluation. Using self-evaluation in a continuous and dynamic way and preparing the grounds for learners to achieve it, could be an effective step towards achieving the goals of education and training and the establishment of this method in schools needs public will for development of this concept in all of education processes. It is necessary to provide a schedule for self-evaluation in order to harmonize different fields of education and so to unify the acts and establishing the self-evaluation system. [ABSTRACT FROM AUTHOR]
- Published
- 2012
108. Role of higher education in lifelong learning.
- Author
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Mohammadi Mehr, M., Maleki, H., Abbas Pour, A., and Khoshdel, A. R.
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HIGHER education ,CONTINUING education ,EDUCATIONAL planning ,TEACHER-student communication ,DEVELOPED countries - Abstract
Introduction: Extensive socio-economic and technological changes have shown a potent effect on educational systems in industrial countries. Concepts and statements such as the Information Society, the Knowledge-Based Economy and the Learning Society has now become prominent characteristics in the main path of political-educational and governmental issues and the importance of learning is vastly distinguishable in each stage of human development. Universities and higher education institutes are nowadays considered as the key places of developing the lifelong learning. The purpose of this review article was to evaluate the lifelong learning and the role of high education in its development. Conclusion: Lifelong learning can be proposed to high education institutes as a set of guidelines instead of an excess topic. Institutes have to develop organized awareness, analyze internal relationships among their different organizational levels and comprehend the manner of these factors' dependence on cognitive and emotional interactions of learning in order to create and develop lifelong learning in high education. Lifelong learning follows the general aims such as generalization of education regarding both quality and quantity and is the expresser of the genuine learning principle in obligatory education and the facilitator of advancement from education to work. National certainty is needed in society and high education institutes for this purpose and this attitude should become a belief and reality in individuals' minds all over the society. [ABSTRACT FROM AUTHOR]
- Published
- 2011
109. NRA of hydrogen in glassy polymeric carbon.
- Author
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Zimmerman, R. L., Ila, D., Jenkins, G. M., Hirvonen, J. K., and Maleki, H.
- Published
- 1997
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110. Evaluating Reliability of System Sequence Diagram Using Fuzzy Petri Net.
- Author
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Nematzadeh, H., Deris, Safaai Bin, Maleki, H., and Nematzadeh, Z.
- Published
- 2009
111. Fuzzy confidence interval for fuzzy process capability index.
- Author
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Parchami, A., Mashinchi, M., and Maleki, H. R.
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FUZZY sets ,INDEXES ,ESTIMATION theory ,CONFIDENCE intervals ,FUZZY numbers - Abstract
Process capability indices are used to determine whether a production process is capable of producing items within specification tolerance. In practice these indices are estimated using sample data, often with quite small sample sizes. Thus, it is of interest to obtain confidence limits for capability index given a sample estimate. Most of the traditional methods for assessing the capability of manufacturing processes are dealing with crisp quality. In this paper we obtain 100(1 - α)% fuzzy confidence interval for &Ctilde;_p fuzzy process capability index, where instead of precise quality we have two membership functions for specification limits. We present several interpretations for introduced fuzzy confidence interval. Some numerical examples are given to clarify the method. [ABSTRACT FROM AUTHOR]
- Published
- 2006
112. Leptin and its association with polycystic ovary syndrome:a twin study.
- Author
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Jahanfar, S., Maleki, H., Mosavi, A.-R., and Jahanfar, M.
- Subjects
- *
LEPTIN , *POLYCYSTIC ovary syndrome , *INSULIN resistance , *HYPERANDROGENISM , *ENDOCRINE gynecology , *OBESITY - Abstract
Polycystic ovary syndrome (PCOS) is a common endocrinopathy with symptoms such as obesity, insulin resistance and hyperandrogenemia. PCOS might be the result of a genetic disorder. Genetic discrepancy in the production of leptin, a product of the obesity gene, may lead to various endocrinopathies such as PCOS. The objective of this study was first, to ascertain the incidence of PCOS, using the gold standard; second, to ascertain the genetic property of leptin; and third, to evaluate the association between leptin concentration and PCOS. A total of 154 Tehran-resident female-female twins were studied. They included 48 pairs of monozygotic (MZ) and 29 pairs of dyzygotic (DZ) twins, aged 15-45 years. Clinical, ultrasound and biochemical findings were used to diagnose PCOS. The incidence of PCOS using biochemical and clinical features was 16.2%. The correlation coefficient between serum leptin levels of MZ twins was higher than that of the DZ twins. The serum level of leptin was similar between subjects with or without PCOS, irrespective of their zygosity. It was concluded that the incidence of PCOS is high among twins, and that leptin is likely to be genetically determined, although the effect of environmental factors cannot be denied. This study did not find any association between the diagnosis of PCOS and leptin level. However, the link between the two may lie with other entities such as eating disorders and/or obesity. [ABSTRACT FROM AUTHOR]
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- 2004
- Full Text
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113. High thermal conductivity negative electrode material for lithium-ion batteries
- Author
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Maleki, H., Selman, J. R., Dinwiddie, R. B., and Wang, H.
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- 2001
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114. Lipid Profile in Women with Polycystic Ovary Syndrome
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Amini Leila, Sadeghi Mohammad Reza, Oskuie Fatemeh, Kamali Koorosh, and Maleki Haleh
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Apolipoprotein A-1 ,Apolipoprotein B Dyslipidemias ,Lipids ,Polycystic Ovary Syndrome ,Medicine - Abstract
Objective: Polycystic ovary syndrome (PCOS) is a disorder of hyperandrogenemia and chronic anovulation, which affects 5-10% of all women. It has been reported that women with PCOS often have serum lipid level elevation. This study compares serum lipid levels in women with and without PCOS. Materials and Methods: Lipid profile [total cholesterol (TC), apolipoprotein A-I, apolipoprotein B, high-density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG), and lipoprotein a] in this comparative cross-sectional study were compared between 33 women with and 44 women without PCOS. All biochemical tests were done using fasting blood samples which were frozen in −80 °C since the previous study. Other data were collected from Iranian twin bank. Data were analyzed with SPSS. P < 0.05 considered as significant level. Results: There was no significant difference between two groups in terms of age, age of menarche and body mass index (BMI). Serum levels of TC, apolipoprotein B, apolipoprotein A-1, HDL, LDL, TG, and lipoprotein did not show any difference between two groups. TG in PCOS women with BMI >25 was significantly higher in comparison with non-PCOS. Conclusion: The present study does not support the notion that PCOS affects serum lipid levels except in the term of TG in PCOS women with BMI > 25. It is suggested to repeat this study within PCOS patients who are insulin resistance.
- Published
- 2014
115. Influence of Cr, Ni, and Zn on the properties of pure clinker phases - Part II. C3A and C4AF
- Author
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Stephan, D., Maleki, H., Knofel, D., Eber, B., and Hardtl, R.
- Published
- 1999
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116. Thermal modeling and design considerations of lithium-ion batteries
- Author
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Hallaj, S. Al, Maleki, H., Hong, J.S., and Selman, J.R.
- Published
- 1999
- Full Text
- View/download PDF
117. Twenty-two cases of autotransfusion.
- Author
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Maleki, H., Bordbar, A., and Fateh, N.
- Published
- 1975
- Full Text
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118. Curriculum designing of Military Emergency Medicine course in a military university
- Author
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Rahmani, R., Mehrvarz, Sh, Zare Ei, E., Abbas Abbaspour, Maleki, H., and Ebrahimnia, M.
119. Collection, evaluation and classification of iranian confectionary sunflower (Helianthus annuus L.) populations using multivaraite statistical techniques
- Author
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Kholghi, M., Bernousi, I., R. Darvishzadeh, Pirzad, A., and Maleki, H. H.
- Subjects
Cluster analysis, confectionary sunflower, genetic variability, principal component analysis - Abstract
Characterization of confectionary sunflower germplasm resources is critical to their efficient collection and management as well as for breeding programs. Thirty six (36) confectionary sunflower populations originating from different regions of Northwest Iran were characterized using 15 agro-morphological traits. Among the studied traits, high coefficients of variation were observed for harvest index (48.36), seed yield (42.07) and petiole length (41.63). Cluster analysis using Ward's method classified the 36 populations into four groups. A large number of genotypes was placed in cluster III (16 genotypes) followed by cluster I (13), cluster IV (4) and cluster II (3). Clusters I, III and VI include genotypes from different sources indicating no association between clustering pattern and eco-geographical distribution of genotypes. The maximum inter-cluster distance of 9.03 was observed between clusters II and VI indicating the possibility of high heterosis if individuals from these two clusters are cross-bred. Principal component analysis resulted in the first four components with Eigen value greater than one accounting for 78% of the total variation. The results of PCA were closely in line with those of cluster analysis. These results can now be used by breeders to develop high yielding sunflower hybrids.Key words: Cluster analysis, confectionary sunflower, genetic variability, principal component analysis.
120. Subclinical eating disorder, polycystic ovary syndrome - Is there any connection between these two conditions through leptin - A twin study
- Author
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Jahanfar Sh, Maleki H, and Amir Mosavi
- Subjects
Adult ,Leptin ,Twins, Monozygotic ,Iran ,Risk Assessment ,Feeding and Eating Disorders ,Reference Values ,Risk Factors ,Surveys and Questionnaires ,Twins, Dizygotic ,Humans ,Female ,Bulimia Nervosa ,Polycystic Ovary Syndrome - Abstract
The genetic property of subclinical eating behaviour (SEB) and the link between SEB and polycystic ovary syndrome (PCOS) has been studied before but the role of leptin within this connection has never been investigated. The objective of this study was 1). to study the genetic property of SEB. 2). To find a link between leptin, SEB and PCOS. One hundred and fifty four (77 pairs) female-female Iranian twins including 96 MZ individuals (48 pairs) and 58 DZ individuals (29 pairs) participated in the study. Clinical, biochemical and ultrasound tools were used to diagnose polycystic ovary syndrome. BITE questionnaire was filled out for subjects. Eight percent of subjects were diagnosed for subclinical eating disorder. No significant difference was found between intraclass correlation of MZ and DZ (z = 0.57, P = 0.569). Serum leptin level correlated significantly with bulimia score (P0.007). The mean (+/-SD) value for bulimia score was found to be higher among PCOS(positive) subjects (3.27 +/- 5.51) in comparison with PCOS(negative) subjects (2.06 +/- 4.48) (P0.001). The genetic property of subclinical eating disorder was not confirmed as shared environment might have played a major role in likeliness of DZ twins as well as MZ. Leptin is linked with both subclinical eating disorder and PCOS.
121. Correlation and sequential path analysis of some agronomic traits in tobacco (Nicotiana tabaccum L.) to improve dry leaf yield
- Author
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Maleki, H. H., Ghasem Karimzadeh, Darvishzadeh, R., and Sarrafi, A.
122. Evaluation of Iranian native apple (Malus X domestica Borkh) germplasm using biochemical and morphological characteristics
- Author
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Farrokhi, J., Darvishzadeh, R., Hatami Maleki, H., and Lotfali Naseri
123. Optimized nanoemulsion synthesis of mono-dispersed Fe3O4 magnetic nanoparticles for biomedical applications and cytotoxicity studies
- Author
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Maleki, H., Abdolreza Simchi, Imani, M., and Mahmoudi, M.
124. Military medicine's role in the armed forces and the need to develop specialized education programs in Iran military medicine
- Author
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Rahmani, R., Shaban Mehrvarz, Zareei Zavaraki, E., Abbaspour, A., and Maleki, H.
125. Evaluation of genetic diversity among Iranian apple (Malus domestica Borkh.) cultivars and landraces using simple sequence repeat markers
- Author
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Farrokhi, J., R. Darvishzadeh, Naseri, L., Mohseni Azar, M., and Hatami Maleki, H.
126. Diallel analysis of yield and It’s related traits in sunflower (Helianthus annuus L.) under well-watered and water-stressed conditions
- Author
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Kholghi, M., Maleki, H. H., and R. Darvishzadeh
- Subjects
sunflower ,Griffing diallel analysis ,general combining ability ,specific combining ability - Abstract
Drought stress is one of the factors which influence sunflower production. Hence, breeding for tolerance to drought stress has become a major focus. In this paper, combining ability, gene action and genetic analysis of several characteristics were studied for five sunflower inbred lines and their ten hybrids (fifteen genotypes). The materials were evaluated in two separate experiments using a Randomized Complete Block Design (RCBD) with three replications in well-watered and waterstressed states and in field condition. Data were analyzed by Griffing’s diallel analysis model 1 (fixed effects) and method 2 (parents and crosses). Combined analysis of experiments revealed significant differences among genotypes for all studied traits. Combining ability analysis revealed that in well-watered conditions, general and specific combining abilities (GCA and SCA) effects were significant for all studied traits except for the leaf number. In water-stressed condition, GCA and SCA effects were significant for all studied traits except for the head and stem diameter. The Griffing diallel analysis showed that the genotype LR4 could be considered as the best combiner with the highest GCA effect for seed yield per plant, number of filled seed, stem diameter and head diameter in the sunflower breeding programs. In both water treatment conditions the cross ‘RHA266xLR4’ showed the highest positive SCA effects and the highest mean value for seed yield per plant.
127. The synthesis of 2,6,7,11-tetraphenylisobenzofuran[b]cyclobutadiene: A new stable antiaromatic compound
- Author
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Firouzabadi, H., primary and Maleki, H., additional
- Published
- 1978
- Full Text
- View/download PDF
128. Importance of monitoring for deep two-seam longwall layouts.
- Author
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Fleck, K., Semborski, C., Christensen, I., and Maleki, H.
- Subjects
LONGWALL mining ,COAL mining ,GATE roads (Mining) ,MINE haulage ,DRILLING & boring - Abstract
The article reports on the implementation of a geologic program for stability improvement and support for deep longwall gateroads at Energy West Mining Co.'s (EWMC) Deer Creek Mine operations in Huntington, Utah. The program involves in-mine and surface exploration drilling, rock mechanics testing, and measurements of structural and depositional condition changes. It notes that the appropriate equipment to wear during the operation is dictated by administrative controls or rules.
- Published
- 2012
129. MULTIOBJECTIVE GEOMETRIC PROGRAMMING WITH FUZZY PARAMETERS.
- Author
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Maleki, H. R. and Mashinchi, M.
- Abstract
Generally, an engineering design problem has multiple objective functions. Some of these problems can be formulated as multiobjective geometric programming models. On the other hand,often in the real world, coefficients of the objective functions are not known precisely. Coefficients may be interpreted as fuzzy numbers, which lead to a multiobjective geometric programming with fuzzy parameters. In this paper, we solve the multiobjective geometric programming problem with fuzzy parameters by applying a linear ranking function. The linear ranking function is used to compare fuzzy numbers. Finally, a numerical example is given. [ABSTRACT FROM AUTHOR]
- Published
- 2007
130. Prediction of long-term closure and stability of underground workings in the waste isolation pilot plant
- Author
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Maleki, H. and Chaturvedi, L.
- Published
- 1997
131. Mine stability evaluation of panel 1 during waste emplacement operations at WIPP
- Author
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Maleki, H [Maleki Technologies Inc., Spokane, WA (United States)]
- Published
- 1998
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132. Temperature dependent fluorescence from Gd 2O 2S:Tb induced by 45 MeV proton irradiation
- Author
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Hollerman, W.A., Jenkins, G.M., Fisher, J.H., Holland, L.R., Williams, E.K., Maleki, H., and Foster, C.C.
- Published
- 1995
- Full Text
- View/download PDF
133. Recent advances with erythrocytes as therapeutics carriers.
- Author
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Hadi Barhaghtalab R, Tanimowo Aiyelabegan H, Maleki H, Mirzavi F, Gholizadeh Navashenaq J, Abdi F, Ghaffari F, and Vakili-Ghartavol R
- Abstract
Erythrocytes have gained popularity as a natural option for in vivo drug delivery due to their advantages, which include lengthy circulation times, biocompatibility, and biodegradability. Consequently, the drug's pharmacokinetics and pharmacodynamics in red blood cells can be considerably up the dosage. Here, we provide an overview of the erythrocyte membrane's structure and discuss the characteristics of erythrocytes that influence their suitability as carrier systems. We also cover current developments in the erythrocyte-based nanocarrier, which could be used for both active and passive targeting of disease tissues, particularly those of the reticuloendothelial system (RES) and cancer tissues. We also go over the most recent discoveries about the in vivo and in vitro uses of erythrocytes for medicinal and diagnostic purposes. Moreover, the clinical relevance of erythrocytes is discussed in order to improve comprehension and enable the potential use of erythrocyte carriers in the management of various disorders., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
134. Accelerating healing of infected wounds with G. glabra extract and curcumin Co-loaded electrospun nanofibrous dressing.
- Author
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Doostan M, Maleki H, Khoshnevisan K, Baharifar H, Doostan M, and Bahrami S
- Subjects
- Animals, Glycyrrhiza chemistry, Wound Infection drug therapy, Wound Infection microbiology, Male, Antioxidants pharmacology, Antioxidants chemistry, Mice, Rats, Curcumin pharmacology, Curcumin chemistry, Curcumin administration & dosage, Wound Healing drug effects, Nanofibers chemistry, Plant Extracts chemistry, Plant Extracts pharmacology, Plant Extracts administration & dosage, Bandages, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents administration & dosage, Chitosan chemistry, Polyvinyl Alcohol chemistry, Escherichia coli drug effects
- Abstract
This study aimed to construct a nanofibrous wound dressing composed of polyvinyl alcohol (PVA) and chitosan (CS) containing curcumin and Glycyrrhiza glabra root extract to inhibit infection and accelerate wound healing. Loading 10 wt% of G. glabra extract-curcumin (50:50) by electrospinng technique resulted in the formation of nanofibers (NFs) with diameter distribution 303 ± 38 and had a uniform and defect-free morphology. FTIR analysis confirmed the loading of the components without adverse interactions. Also, the results showed extremely high porosity, extraordinary liquid absorption capacity, and complete wettability. In addition, G. glabra extract-curcumin showed significant antioxidant activity and their release profile from NFs was continuous and sustained. Also, the prepared NF could inhibit the growth of both Gram-positive Saureus and Gram-negative E. coli strains. Wound healing evaluation in the infected animal model showed that the NFs caused full wound closure and accelerated skin regeneration. The studies on inhibiting the bacteria growth at the wound site also revealed complete inhibitory effects. Moreover, histopathology studies confirmed the complete regeneration of skin layers, formation of collagen fibers, and angiogenesis. Finally, PVA/CS NFs containing G. glabra extract-curcumin as a multifunctional bioactive wound dressing presented a promising approach for promoting the healing of infected wounds., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
135. Optimizing Gaussian process regression (GPR) hyperparameters with three metaheuristic algorithms for viscosity prediction of suspensions containing microencapsulated PCMs.
- Author
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Hai T, Basem A, Alizadeh A, Sharma K, Jasim DJ, Rajab H, Ahmed M, Kassim M, Singh NSS, and Maleki H
- Abstract
Suspensions containing microencapsulated phase change materials (MPCMs) play a crucial role in thermal energy storage (TES) systems and have applications in building materials, textiles, and cooling systems. This study focuses on accurately predicting the dynamic viscosity, a critical thermophysical property, of suspensions containing MPCMs and MXene particles using Gaussian process regression (GPR). Twelve hyperparameters (HPs) of GPR are analyzed separately and classified into three groups based on their importance. Three metaheuristic algorithms, namely genetic algorithm (GA), particle swarm optimization (PSO), and marine predators algorithm (MPA), are employed to optimize HPs. Optimizing the four most significant hyperparameters (covariance function, basis function, standardization, and sigma) within the first group using any of the three metaheuristic algorithms resulted in excellent outcomes. All algorithms achieved a reasonable R-value (0.9983), demonstrating their effectiveness in this context. The second group explored the impact of including additional, moderate-significant HPs, such as the fit method, predict method and optimizer. While the resulting models showed some improvement over the first group, the PSO-based model within this group exhibited the most noteworthy enhancement, achieving a higher R-value (0.99834). Finally, the third group was analyzed to examine the potential interactions between all twelve HPs. This comprehensive approach, employing the GA, yielded an optimized GPR model with the highest level of target compliance, reflected by an impressive R-value of 0.999224. The developed models are a cost-effective and efficient solution to reduce laboratory costs for various systems, from TES to thermal management., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
136. Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.
- Author
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Zorrón M, Cabrera AL, Sharma R, Radhakrishnan J, Abbaszadeh S, Shahbazi MA, Tafreshi OA, Karamikamkar S, and Maleki H
- Subjects
- Humans, Animals, Drug Delivery Systems methods, Hydrogels chemistry, Bone Regeneration drug effects, Nanostructures chemistry, Nanostructures therapeutic use
- Abstract
This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D-material integrated hydrogels, with a focus on their performance in bone-related applications. Various synthesis methods and types of 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, and MXene are discussed, along with strategies for their incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical properties, high surface area, strong near-infrared (NIR) photon absorption and controlled release capabilities, making them suitable for a range of regeneration and therapeutic applications. In cancer therapy, 2D-material-based hydrogels show promise for photothermal and photodynamic therapies, and drug delivery (chemotherapy). The photothermal properties of these materials enable selective tumor ablation upon NIR irradiation, while their high drug-loading capacity facilitates targeted and controlled release of chemotherapeutic agents. Additionally, 2D-materials -infused hydrogels exhibit potent antibacterial activity, making them effective against multidrug-resistant infections and disruption of biofilm generated on implant surface. Moreover, their synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, and immunotherapy to enhance therapeutic outcomes. In bio-imaging, these materials serve as versatile contrast agents and imaging probes, enabling their real-time monitoring during tumor imaging. Furthermore, in bone regeneration, most 2D-materials incorporated hydrogels promote osteogenesis and tissue regeneration, offering potential solutions for bone defects repair. Overall, the integration of 2D materials into hydrogels presents a promising platform for developing multifunctional theragenerative biomaterials., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
137. Enhanced healing of burn wounds by multifunctional alginate-chitosan hydrogel enclosing silymarin and zinc oxide nanoparticles.
- Author
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Valadi M, Doostan M, Khoshnevisan K, Doostan M, and Maleki H
- Abstract
Multifunctional wound dressings have been applied for burn injuries to avoid complications and promote tissue regeneration. In the present study, we fabricated a natural alginate-chitosan hydrogel comprising silymarin and green-synthesized zinc oxide nanoparticles (ZnO NPs). Then, the physicochemical attributes of ZnO NPs and loaded hydrogels were analyzed. Afterward, wound healing efficacy was evaluated in a rat model of full-thickness dermal burn wounds. The findings indicated that ZnO NPs were synthesized via reduction with phytochemicals from Elettaria cardamomum seeds extract. The microscopic images exhibited fairly spherical ZnO NPs (35-45 nm), and elemental analysis verified the relevant composition. The hydrogel, containing silymarin and biosynthesized ZnO NPs, displayed a uniform appearance, smooth surfaces, and a porous structure. Moreover, infrared spectroscopy identified functional groups, confirming the successful loading without adverse interactions. The obtained hydrogel exhibited great water absorption, high porosity, sustainable degradation for several days, and enhanced antioxidant capability of the combined loaded component. In vivo studies revealed faster and superior wound healing, achieving nearly complete closure by day 21. Histopathology confirmed improved cell growth, tissue regeneration, collagen deposition, and neovascularization. It is believed that this multifunctional hydrogel-based wound dressing can be applied for effective burn wound treatment., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests., (Copyright © 2024 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
138. An evaluation of fungal contamination and its relationship with PM levels in public transportation systems.
- Author
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Baboli Z, Hayati R, Mosavion K, Goudarzi M, Sadeghi-Nejad B, Ghanbari F, Maleki H, Yazdani M, Hayat Davoudi G, and Goudarzi G
- Subjects
- Air Pollution, Indoor analysis, Transportation, Iran, Environmental Monitoring methods, Air Pollutants analysis, Fungi isolation & purification, Air Microbiology, Particulate Matter analysis
- Abstract
Transmission of fungi in the air and its impact on health are regarded as important public health issues. Bioaerosols play an important role in causing or exacerbating infectious diseases, acute toxic effects, allergies, and cardiopulmonary symptoms. As many people use the public transportation system daily, it is necessary to determine the type and manner of dispersal and abundance of airborne fungi in public transport places. Three public transportation systems including a bus station, a train station, and an airport in Ahvaz city (Iran) were examined. At each of these stations, the air samples were taken from inside and outside the hall stations, and in-vehicle. A bio-stage Anderson sampler was used by suctioning air and passing it over a Petri dish containing culture medium Sabouraud Dextrose Agar (SDA). Relative humidity (RH, %), temperature (T,
◦ C), and mass concentration of particulate matter (PM1 , PM2.5 , and PM10, μg/m3 ) at the sampling points were measured. The highest concentration of airborne fungi was observed in the airport. The concentration of fungi in the ambient air was higher than that in the indoor air of halls and in-vehicle. In all sampling points, the ambient predominant airborne fungi were Cladosporium and Alternaria, while the indoor predominant airborne fungi were Cladosporium, Aspergillus, and Penicillium. The indoor to outdoor ratio showed that the fungi were of an external origin. Due to the influence of the ambient air on indoor air, it is recommended to use proper ventilation and enhance the hygiene level of vehicles in public transportation systems to reduce exposure to environmentally pathogenic bioaerosols., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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139. Multiphasic investigations imply transfer of orange-/red-pigmented strains of the bean pathogen Curtobacterium flaccumfaciens pv. flaccumfaciens to a new species as C. aurantiacum sp. nov., elevation of the poinsettia pathogen C. flaccumfaciens pv. poinsettiae to the species level as C. Poinsettiae sp. nov., and synonymy of C. albidum with C. citreum.
- Author
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Osdaghi E, Taghavi SM, Hamidizade M, Kariminejhad M, Fazliarab A, Hajian Maleki H, Baeyen S, Taghouti G, Jacques MA, Van Vaerenbergh J, and Portier P
- Subjects
- Iran, Euphorbia microbiology, Sequence Analysis, DNA, Bacterial Typing Techniques, Fabaceae microbiology, Phenotype, Actinomycetaceae classification, Actinomycetaceae genetics, Actinomycetaceae isolation & purification, United States, Plant Diseases microbiology, Phylogeny, RNA, Ribosomal, 16S genetics, DNA, Bacterial genetics
- Abstract
Curtobacterium flaccumfaciens (Microbacteriaceae), a plant-pathogenic coryneform species includes five pathovars with valid names and a number of proposed - but unvalidated - new members. In this study, phenotypic features and DNA similarity indexes were investigated among all C. flaccumfaciens members. Results showed that the C. flaccumfaciens pv. poinsettiae strains causing bacterial canker of Euphorbia pulcherrima in the USA as well as the orange-/red-pigmented strains of C. flaccumfaciens pv. flaccumfaciens pathogenic on dry beans in Iran are too distinct from each other and from the type strain of the species to be considered members of C. flaccumfaciens. Hence, the latter two groups were elevated at the species level as C. poinsettiae sp. nov. (ATCC 9682
T = CFBP 2403T = ICMP 2566T = LMG 3715T = NCPPB 854T as type strain), and C. aurantiacum sp. nov. (50RT = CFBP 8819T = ICMP 22071T as type strain). Within the emended species C. flaccumfaciens comb. nov., yellow-pigmented strains causing bacterial wilt of dry beans and those causing bacterial canker of Euphorbia pulcherrima in Europe were retained as C. flaccumfaciens pv. flaccumfaciens and C. flaccumfaciens pv. poinsettiae, respectively; while taxonomic position of the sugar beet pathogen C. flaccumfaciens pv. beticola ATCC BAA144PT was confirmed. The newly described onion pathogen C. allii was also reclassified as C. flaccumfaciens pv. allii with the pathotype strain LMG 32517PT . Furthermore, C. flaccumfaciens pv. basellae causing bacterial leaf spot of malabar spinach (Basella rubra) was transferred to C. citreum pv. basellae with ATCC BAA143PT as pathotype., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier GmbH. All rights reserved.)- Published
- 2024
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140. Encapsulation of propolis extracted with methylal in the chitosan nanoparticles and its antibacterial and cell cytotoxicity studies.
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Vaseghi A, Parchin RA, Chamanie KR, Herb M, Maleki H, and Sadeghizadeh M
- Subjects
- Escherichia coli, Staphylococcus aureus, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Solvents, Ethanol, Flavonoids, Propolis pharmacology, Chitosan chemistry, Nanoparticles chemistry, Methyl Ethers
- Abstract
In this study we develop novel type of antibacterial chitosan-propolis NPs to improve theantimicrobial activity against various pathogens. To this aim, we primarily extracted propolis with methylal and ethanol as green solvents and its encapsulation with chitosan NPs. The developed propolis loaded chitosan NPs indicated antimicrobial and anti-biofilm properties against various gram positive and negative. FTIR revealed the successful encapsulation of the propolis extract with Ethanol (PE) and Methylal (PM) into the chitosan nano career matrix. HPLC and GC-MASS also confirmed the presence of flavonoids and phenols compounds of propolis extracted with both solvents. In addition, we confirmed the total phenolic and flavonoid compounds in propolis by calorimetric method of Folin-Ciocalteu and aluminum trichloride complex formation assays, respectively. PE-CH and PM-CH were optimized regarding physicochemical properties such as particle size, zeta potential, and poly dispersity index (PDI) index. DLS and SEM micrographs confirmed a spherical morphology in a range of 360-420 nm with Z potential values of 30-48 mV and PDI of 0.105-0.166 for PE-CH and PM-CH, respectively. The encapsulation efficiency was evaluated using colorimetric analysis, with median values ranging from 90 to 92%. The MIC values within the range of 2 to 230 µg/ml and MBC values between 3 to 346 μg/ml against both gram-positive and negative bacteria. While both PE and PM showed a significant reduction in the number of E. coli, S. aureus, and S. epidermidis, the use of PE-CH and PM-CH led to a statistically significant and greater reduction in number of E. coli, S. aureus, and S. epidermidis strains on the biofilm, pre-formed biofilm and planktonic phases. Besides, the DPPH assay showed significant antioxidant activity for these NPs within the range of 36 to 92%. MTT assay for MHFB-1, HFF, L929, MDF, and MCF-7 cells exhibited statistically significant differences in each other that show the IC50 between 60-160 µg/ml for normal cells and 20 for cancer cells. Finally the present study indicated that both PM and PM-CH greater than PE and PE-CH in which contain high flavonoid and phenolic contents with a high antioxidation potential antioxidant properties, which could be beneficial for cell proliferation and antibiotic and anticancer applications., (© 2024. The Author(s).)
- Published
- 2024
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141. Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties.
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Abie N, Ünlü C, Pinho AR, Gomes MC, Remmler T, Herb M, Grumme D, Tabesh E, Shahbazi MA, Mathur S, Mano JF, and Maleki H
- Abstract
Biomaterial-mediated bone tissue engineering (BTE) offers an alternative, interesting approach for the restoration of damaged bone tissues in postsurgery osteosarcoma treatment. This study focused on synthesizing innovative composite inks, integrating self-assembled silk fibroin (SF), tannic acids (TA), and electrospun bioactive glass nanofibers 70SiO
2 -25CaO-5P2 O5 (BGNF). By synergistically combining the unique characteristics of these three components through self-assembly and microextrusion-based three-dimensional (3D) printing, our goal was to produce durable and versatile aerogel-based 3D composite scaffolds. These scaffolds were designed to exhibit hierarchical porosity along with antibacterial, antiosteosarcoma, and bone regeneration properties. Taking inspiration from mussel foot protein attachment chemistry involving the coordination of dihydroxyphenylalanine (DOPA) amino acids with ferric ions (Fe3+ ), we synthesized a tris-complex catecholate-iron self-assembled composite gel. This gel formation occurred through the coordination of oxidized SF (SFO) with TA and polydopamine-modified BGNF (BGNF-PDA). The dynamic nature of the coordination ligand-metal bonds within the self-assembled SFO matrix provided excellent shear-thinning properties, allowing the SFO-TA-BGNF complex gel to be extruded through a nozzle, facilitating 3D printing into scaffolds with outstanding shape fidelity. Moreover, the developed composite aerogels exhibited multifaceted features, including NIR-triggered photothermal antibacterial and in vitro photothermal antiosteosarcoma properties. In vitro studies showcased their excellent biocompatibility and osteogenic features as seeded cells successfully differentiated into osteoblasts, promoting bone regeneration in 21 days. Through comprehensive characterizations and biological validations, our antibacterial scaffold demonstrated promise as an exceptional platform for concurrent bone regeneration and bone cancer therapy, setting the stage for their potential clinical application.- Published
- 2024
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142. Diatom-inspired silicification process for development of green flexible silica composite aerogels.
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Tan V, Berg F, and Maleki H
- Abstract
In this study, we have developed novel biomimetic silica composite aerogels and cryogels for the first time, drawing inspiration from the natural diatom's silicification process. Our biomimetic approach involved the modification of tyrosinase-mediated oxidized silk fibroin (SFO) surfaces with polyethyleneimine (PEI). This modification introduced ample amine groups onto the SF polymer, which catalyzed the silicification of the SFO-PEI gel surface with silicic acid. This process emulates the catalytic function of long-chain polyamines and silaffin proteins found in diatoms, resulting in a silica network structure on the primary SFO-PEI network gel's surface. The SFO-PEI gel matrix played a dual role in this process: (1) It provided numerous amine functional groups that directly catalyzed the silicification of silicic acid on the porous structure's exterior surface, without encapsulating the created silica network in the gel. (2) It served as a flexible mechanical support facilitating the creation of the silica network. As a result, the final ceramic composite exhibits a mechanically flexible nature (e.g., cyclic compressibility up to 80% strain), distinguishing it from conventional composite aerogels. By mimicking the diatom's silicification process, we were able to simplify the development of silica-polymer composite aerogels. It eliminates the need for surfactants, multi-step procedures involving solvent exchange, and gel washing. Instead, the reaction occurs under mild conditions, streamlining the composite aerogels fabrication process., (© 2024. The Author(s).)
- Published
- 2024
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143. Demographic and biological factors in interrelationships between physical, cognitive, psychological, and social frailty in community-dwelling older adults: Data from the Birjand Longitudinal Aging Study (BLAS).
- Author
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Chehrehgosha M, Sharifi A, Meftah AM, Maleki H, Sajjadi-Jazi SM, Baharifar H, Khoshnevisan K, and Sharifi F
- Subjects
- Aged, Humans, Middle Aged, Independent Living, Frail Elderly, Biological Factors, Cohort Studies, Cross-Sectional Studies, Aging, Geriatric Assessment, Cognition, Frailty diagnosis
- Abstract
Complex interrelationships may exist among different types of frailty. This study aimed to evaluate the demographic and biological factors that influence the different types of frailty in community-dwelling older adults in Iran through a cross-sectional analysis of data obtained from the Birjand Longitudinal Aging Study. This study is an ongoing cohort study of people aged 60 years and over and employed a multistage stratified cluster random sampling. Anthropometric measures were obtained by nurses. The "Fried frailty phenotype" was defined as physical frailty. Cognitive frailty was assessed using the Mini-Mental State Examination. Social frailty was evaluated by some questions, and psychological frailty was assessed using a patient health questionnaire. Blood samples were taken after overnight fasting. All statistical analyses were performed using Stata12 (Texas, USA) and Python. Some type of frailty had been experienced by 62.27 % of the older adults. Cognitive frailty was the dominant type of frailty (55.69 %). Based on multivariate regression analysis, age, sex, education, and marital status were the influencing factors in all types of frailty. Network analysis revealed that physical, cognitive, psychological, and social frailty had synergistic effects on each other, and age and sex had dominant interactions with frailty types. Cognitive frailty was dominant compared with other types of frailty, indicating the need to detect cognitive frailty at the earliest stage and to implement an appropriate program to manage cognitive frailty in older adults., Competing Interests: Declaration of competing interest The authors declare that they have no competing interest., (Copyright © 2023. Published by Elsevier B.V.)
- Published
- 2024
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144. Zingiber officinale and thymus vulgaris extracts co-loaded polyvinyl alcohol and chitosan electrospun nanofibers for tackling infection and wound healing promotion.
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Maleki H, Doostan M, Khoshnevisan K, Baharifar H, Maleki SA, and Fatahi MA
- Abstract
Infections are severe complications associated with chronic wounds and tardy healing that should be timely treated to achieve rapid and proper tissue repair. To hinder such difficulties, a nanofibrous mat composed of polyvinyl alcohol and chitosan (PVA/CS) was developed by electrospinning method, containing thyme ( Thymus vulgaris ) and ginger ( Zingiber officinale ) extracts. The mat containing 10 wt% of the extracts (at the ratio of 50:50) exposed the nanofibers (NFs) with the nanoscale diameter (average 382 ± 60 nm), smooth surface, and defect-free morphology. Likewise, the relevant analyses of the loaded mat displayed high wettability, porosity, and liquid absorption capacity without any adverse interaction. The obtained mat also provided a high antioxidant activity, and its release profile was continuous and sustained for nearly 72 h. Besides, it inhibited the growth of both Gram-positive S. aureus and Gram-negative E. coli strains. Furthermore, the proposed mat significantly accelerated cutaneous wound healing in bacterial-infected rats by preventing bacteria growth at the wound site. At last, histopathology analysis confirmed the ample regeneration of skin structures, forming collagen fibers and appendages. Overall, the proposed mat containing ginger-thyme extracts provides multiple therapeutic capabilities with promising solutions for inhibiting wound infection and accelerating the healing process., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests., (© 2023 The Authors.)
- Published
- 2023
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145. Molecular evidence depicts genetic divergence among Agropyron elongatum and A. cristatum accessions from gene pool of Iran.
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Hatami Maleki H, Mohammadi R, Firouzkuhi F, Darvishzadeh R, and Zeinalzadeh-Tabrizi H
- Subjects
- Gene Pool, Iran, Bayes Theorem, Poaceae, Soil, Agropyron genetics
- Abstract
The genus Agropyron has an important role in soil protection and forage production in rangelands. The investigation utilized 37 ISSR primers, resulting in the detection of 956 loci within the A. elongatum genome and 705 loci within the A. cristatum genome. The findings revealed a high level of polymorphism, with 97% of loci in A. elongatum and 84% of loci in A. cristatum exhibiting variability. Notably, the primer (AC)8GCT emerged as a promising candidate for evaluating genetic diversity due to its ability to amplify numerous loci in both species. Using both the UPGMA algorithm and Bayesian analysis, the examined Agropyron accessions were categorized into two subgroups based on their respective species. The Q values associated with these subgroups suggested that certain accessions, namely "G16," "G19," "G20," "G21," "G22," "G23," "G24," and "G25," displayed potential admixture genomes. An analysis of molecular variance (AMOVA) underscored the significance of within-species variability, which accounted for 69% of the overall diversity, compared to between-species variability at 31%. Various genetic diversity parameters, including Na, Ne, I, He, and the number of private loci, were found to be higher in A. elongatum when compared to A. cristatum. Furthermore, Jaccard similarity coefficients ranged from 0.33 to 0.66 in A. cristatum and from 0.25 to 0.7 in A. elongatum, indicating the extent of genetic relatedness among these species. Intriguingly, the study identified two and three heterotic groups in A. cristatum and A. elongatum, respectively, which could be harnessed in the development of synthetic varieties to exploit heterosis. The results also indicated that a small proportion of ISSR loci pairs (5.2% in A. elongatum and 0.5% in A. cristatum) exhibited significant levels of linkage disequilibrium (LD) (P≤0.05), suggesting the potential utility of LD-based association mapping in Agropyron species. In conclusion, this research sheds light on the genetic diversity of Agropyron species and provides valuable insights into their potential applications in soil protection and forage production, as well as the prospects for enhancing genetic variability and heterosis in these species., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Hatami Maleki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2023
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146. Identification of the chemical profile and evaluation of the antimicrobial effect of Eryngium billardieri Delar essential oil component against bacterial species of agricultural and food interest.
- Author
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Hajian-Maleki H and Shams-Bakhsh M
- Abstract
Studies on the antibacterial activity of the essential oil of E. billardieri are limited. In this study, we identified this herb as a natural complex effective against several bacteria by employing disk diffusion and broth microdilution susceptibility methods. Primary estimation of the antimicrobial effect of this herbal compound by disk diffusion method showed that the oil could inhibit the growth of the tested bacteria by the appearance of haloes between 8.25 and 21.25 mm. In the next step, the oil was found to be active against all 24 tested Gram-negative and Gram-positive bacteria in the broth media, at minimum inhibitory concentrations ranging from 0.67 to 34.17 g L
-1 . Furthermore, Enterococcus faecalis and Curtobacterium flaccumfaciens pv. flaccumfaciens were the most sensitive food and plant pathogenic bacteria, respectively. Gas chromatography-mass spectrometry analysis was conducted to assign the ingredients present in the oil; 34 different components representing 95.71% of the total oil were identified, with n-hexadecanoic acid being the dominant component, followed by 2-Pentadecanone, 6,10,14-trimethyl, 1H-Indene, 1-ethylideneoctahydro-, and Cinnamyl tiglate. These findings demonstrate, for the first time, a broad spectrum of the antibacterial capacity of E. billardieri . Based on these observations, the oil could be applied as a natural preservative with the potential for designing novel products. Its bioactive agents can also be isolated for further use in the food and agricultural industries., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Hajian-Maleki and Shams-bakhsh.)- Published
- 2023
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147. Sigmoid volvulus secondary to undescended testicle: Report of first case in the literatures.
- Author
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Ahmadinejad M, Mammohammadi A, Hajialigol A, Tajik A, Maleki H, Pak H, and Zebarjadi Bagherpour J
- Abstract
Sigmoid volvulus accounts for 20%-50% of colonic obstructions in Eastern countries. This occurs mostly in patients with a lack of mobility and a history of chronic constipation. There are some very known complications of a undescended intra-abdominal testicle such as cancer, ischemia, and infertility; But the rotation of the colon around the spermatic cord of one UDT is a very rare phenomenon that there is no similar report. A 67-year-old man came to the emergency department with a complaint of abdominal pain and obstipation. On examination, patient was febrile ( T : 38.5) and had mild general tenderness. According to the appearance of coffee beans in the X-ray, the diagnosis of sigmoid volvulus was made. In the requested tests, leukocytosis was observed. Rectosigmoidoscopy was unsuccessful. The patient underwent laparotomy. After manual untwisting, a tubular structure at the base of the meso-sigmoid was noticed. With further exploration, the testis was observed intra-abdominally. Orchidectomy and sigmoidectomy were performed by Hartmann's method. Sigmoid volvulus is one of the common cases that surgeons frequently encounter. The case scenarios are often the same, and from experience, most cases result from a long meso and an elongated sigmoid secondary to prolonged constipation. Therefore, it is clear that a scrotal examination would not be part of the routine examination of a patient with sigmoid volvulus. In this article, by reporting a very rare etiology for a very common pathology, we tried to point out the importance of head-to-toe examination in all patients., Competing Interests: All authors confirm that there is no conflict of interest., (© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
- Published
- 2023
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148. MXene-Integrated Silk Fibroin-Based Self-Assembly-Driven 3D-Printed Theragenerative Scaffolds for Remotely Photothermal Anti-Osteosarcoma Ablation and Bone Regeneration.
- Author
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Pektas HK, Demidov Y, Ahvan A, Abie N, Georgieva VS, Chen S, Farè S, Brachvogel B, Mathur S, and Maleki H
- Abstract
Aiming to address the bone regeneration and cancer therapy functionalities in one single material, in this study, we developed a dual-functional theragenerative three-dimensional (3D) aerogel-based composite scaffold from hybridization of photo-cross-linked silk fibroin (SF) biopolymer with MXene (Ti
3 C2 ) two-dimensional (2D) nanosheets. To fabricate the scaffold, we first develop a dual-cross-linked SF-based aerogel scaffold through 3D printing and photo-cross-linking of the self-assembly-driven methacrylate-modified SF (SF-MA) gel with controlled pore size, macroscopic geometry, and mechanical stability. In the next step, to endow a remotely controlled photothermal antiosteosarcoma ablation function to fabricated aerogel scaffold, MXene 2D nanosheets with strong near-infrared (NIR) photon absorption properties were integrated into the 3D-printed scaffolds. While 3D-printed MXene-modified dual-cross-linked SF composite scaffolds can mediate the in vitro growth and proliferation of preosteoblastic cell lines, they also endow a strong photothermal effect upon remote irradiation with NIR laser but also significantly stimulate bone mineral deposition on the scaffold surface. Additionally, besides the local release of the anticancer model drug, the generated heat (45-53 °C) mediated the photothermal ablation of cancer cells. The developed aerogel-based composites and chosen therapeutic techniques are thought to render a significant breakthrough in biomaterials' future clinical applications., Competing Interests: The authors declare no competing financial interest., (© 2023 The Authors. Published by American Chemical Society.)- Published
- 2023
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149. Clavibacter lycopersici sp. nov.: a peach-colored actinobacterium isolated from symptomless tomato plant.
- Author
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Osdaghi E, Taghavi SM, Hamidizade M, Fazliarab A, Hajian Maleki H, Li X, Jacques MA, and Portier P
- Subjects
- Bacterial Typing Techniques, Base Composition, Clavibacter, DNA, Bacterial genetics, Fatty Acids chemistry, Phylogeny, RNA, Ribosomal, 16S genetics, Sequence Analysis, DNA, Actinobacteria, Solanum lycopersicum
- Abstract
In 2015, Gram-positive peach-coloured actinobacterial strains were isolated from symptomless tomato phyllosphere in Iran. Biochemical and physiological characteristics, as well as 16S rRNA phylogeny showed that the strains belong to Clavibacter sp., while they were non-pathogenic on the host of isolation, and morphologically distinct from the tomato pathogen C. michiganensis and other plant-associated bacteria. Multilocus sequence analysis of five housekeeping genes showed that the two peach-coloured strains CFBP 8615
T (Tom532T ) and CFBP 8616 (Tom495) were phylogenetically distinct from all validly described Clavibacter species. Whole genome sequence-based indices, i.e. average nucleotide identity (orthoANI) and digital DNA-DNA hybridization (dDDH), showed that the two peach-colored strains share nearly 100 % orthoANI value with one another, while they differ from all validly described Clavibacter species with the orthoANI/dDDH values <93 % and <50 %, respectively. Thus, based on both phenotypic features and orthoANI/dDDH indices the peach-coloured strains could belong to a new species within Clavibacter . In this study, we provide a formal species description for the peach-coloured tomato-associated Clavibacter strains. Clavibacter lycopersici sp. nov. is proposed for the new species with Tom532T = CFBP 8615T = ICMP 22100T as type strain.- Published
- 2023
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150. A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches Using Electrospinning and Electrospray.
- Author
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Azimi B, Ricci C, Macchi T, Günday C, Munafò S, Maleki H, Pratesi F, Tempesti V, Cristallini C, Bruschini L, Lazzeri A, Danti S, and Günday-Türeli N
- Abstract
The delivery of drugs through the skin barrier at a predetermined rate is the aim of transdermal drug delivery systems (TDDSs). However, so far, TDDS has not fully attained its potential as an alternative to hypodermic injections and oral delivery. In this study, we presented a proof of concept of a dual drug-loaded patch made of nanoparticles (NPs) and ultrafine fibers fabricated by using one equipment, i.e., the electrospinning apparatus. Such NP/fiber systems can be useful to release drugs locally through the skin and the tympanic membrane. Briefly, dexamethasone (DEX)-loaded poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBHV) fiber meshes were decorated with rhodamine (RHO)-loaded poly(lactic- co -glycolic acid) (PLGA) NPs, with RHO representing as a second drug model. By properly tuning the working parameters of electrospinning, DEX-loaded PHBHV fibers (i.e., by electrospinning mode) and RHO-loaded PLGA NPs (i.e., by electrospray mode) were successfully prepared and straightforwardly assembled to form a TDDS patch, which was characterized via Fourier transform infrared spectroscopy and dynamometry. The patch was then tested in vitro using human dermal fibroblasts (HDFs). The incorporation of DEX significantly reduced the fiber mesh stiffness. In vitro tests showed that HDFs were viable for 8 days in contact with drug-loaded samples, and significant signs of cytotoxicity were not highlighted. Finally, thanks to a beaded structure of the fibers, a controlled release of DEX from the electrospun patch was obtained over 4 weeks, which may accomplish the therapeutic objective of a local, sustained and prolonged anti-inflammatory action of a TDDS, as is requested in chronic inflammatory conditions, and other pathological conditions, such as in sudden sensorineural hearing loss treatment.
- Published
- 2023
- Full Text
- View/download PDF
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