101. HLA gene and haplotype frequencies in spina bifida. Population and family studies.
- Author
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De Bruyere M, Kulakowski S, Malchaire J, Delire M, and Sokal G
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Alleles, Gene Frequency, HLA Antigens analysis, Spina Bifida Occulta genetics
- Abstract
The search for HLA association in spina bifida is particularly interesting since this condition can be associated with the effects of the T locus in mice. Gene and haplotype frequencies in 32 unrelated patients suffering from spina bifida were studied. Gene frequency of HLA-B5 and haplotype frequency of A2, B5 were increased without reaching signification levels. Fourteen families were examined clinically and radiologically. A high frequency of spina bifida occulta and other vertebral abnormalities was found without evidence of linkage with HLA haplotypes.
- Published
- 1977
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