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2,032 results on '"Maibach H"'

103. Evidence-Based Management of Hand Eczema

Author

John, S, Johansen, J, Rustemeyer, T, Elsner, P, Maibach, H, Schuttelaar, Marie L.A., Oosterhaven, Jart A.F., Romeijn, Geertruida L.E., Christoffers, Wietske A., Voorberg, Angelique N., John, S, Johansen, J, Rustemeyer, T, Elsner, P, Maibach, H, Schuttelaar, Marie L.A., Oosterhaven, Jart A.F., Romeijn, Geertruida L.E., Christoffers, Wietske A., and Voorberg, Angelique N.

Abstract

Hand eczema is a common skin disease with a wide variation in morphology and a complex etiology based on endogenous and exogenous factors. The diagnosis of hand eczema is based on patient history, exposure assessment, physical examination, and the results of patch testing. Management of hand eczema starts with education of the patient on the etiology of the disease, and the needed changes in behavior regarding skin care and preventive measures, and avoidance of relevant exposure factors. In many cases, medical treatment is needed for successful management of the disease; use of medication can only be successful with proper education and avoidance of relevant exposure.

Published
2019

137. Major Role for TRPV1 and InsP3R in PAR2-Elicited Inflammatory Mediator Production in Differentiated Human Keratinocytes

Author

Misery, Laurent, Brenaut, Emilie, Pierre, Ophélie, Le Garrec, Raphaele, Gouin, Olivier, Lebonvallet, Nicolas, Abasq‐Thomas, Claire, Talagas, Matthieu, Le Gall‐Ianotto, Christelle, Besner‐Morin, Catherine, Fluhr, Joachim, Leven, Cyril, Chéret, Jérémy, Ponce, Leslie, Bertolini, Marta, Paus, Ralf, L’Herondelle, Killian, Fouyet, Sophie, Leschiera, Raphael, Le Gall-Ianotto, Christelle, Philippe, Reginald, Buscaglia, Paul, Mignen, Olivier, Lewis, Richard, Michel, Laurence, Devergne, C., Kerspern, H., Poizeau, F., Eveillard, J.R., Carré, J.L., Weisshaar, E., Evers, A.W.M., Huet, F., Ständer, S., Reich, A., Berardesca, E., Serra‐Baldrich, E., Wallengren, J., Linder, D., Fluhr, J.W., Szepietowski, J.C., Maibach, H., Honari, Golara, Takamori, Kenji, Richters, Renée, Barnetche, T., Roudot, A.‐C., Ficheux, A.‐S., Le Calloch, Ronan, Couturier, Marie‐Anne, Chauveau, Aurélie, Lippert, Eric, Carré, Jean‐Luc, Ianotto, Jean‐Christophe, Bataille, Adeline, Genin, Emmanuelle, L'Herondelle, Killian, Legoux, Nelig, Buhé, Virginie, Sakka, Mehdi, Kerfant, Nathalie, Carré, Jean-Luc, Lefeuvre, Luc, Université de Brest (UBO), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), and Laboratoire sur les interactions Epithéliums Neurones (LIEN)

Subjects
0301 basic medicine, Keratinocytes, ORAI1 Protein, [SDV]Life Sciences [q-bio], Primary Cell Culture, TRPV Cation Channels, Inflammation, Dermatitis, Dermatology, Biochemistry, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], medicine, Humans, Inositol 1,4,5-Trisphosphate Receptors, Receptor, PAR-2, Calcium Signaling, RNA, Small Interfering, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Calcium signaling, Phospholipase C, ORAI1, NF-κB, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Cell Differentiation, Cell Biology, Inositol trisphosphate receptor, Cell biology, 030104 developmental biology, medicine.anatomical_structure, chemistry, Tumor necrosis factor alpha, medicine.symptom, Inflammation Mediators, Keratinocyte, Oligopeptides, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

PAR2 activation in basal keratinocytes stimulates inflammation via the Ca2+-dependent production of mediators such as IL-1β, TNF-α, and TSLP. In this study, we investigated PAR2 calcium signaling and the consequent production of inflammatory mediators in differentiated human primary keratinocytes (DhPKs). Stimulation with the PAR2-activating peptide SLIGKV promoted Ca2+ store depletion in both undifferentiated human primary keratinocytes and DhPKs. SLIGKV-evoked Ca2+ store depletion did not trigger the store-operated Ca2+ entry (i.e., SOCE) through ORAI1 in DhPKs compared with undifferentiated human primary keratinocytes. The inhibition of phospholipase C and the concomitant inhibition of TRPV1 and inositol triphosphate receptor in DhPKs abrogated the SLIGKV-evoked Ca2+ store depletion; NF-κB activity; and the production of inflammatory mediators such as IL-1β, TNF-α, and TSLP. Taken together, these results indicate a key role for both InsP3R and TRPV1 in Ca2+ internal stores in the PAR2-evoked Ca2+ release and consequent skin inflammation in DhPKs. These findings may provide clues to understanding the pathological role of DhPKs in skin disorders in which PAR2 is known to be involved, such as atopic dermatitis, Netherton syndrome, and psoriasis.

Published
2017
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143. Skin absorption through atopic dermatitis skin:a systematic review

Author

Halling-Overgaard, A-S, Kezic, S, Jakasa, I, Engebretsen, K A, Maibach, H, Thyssen, J P, Halling-Overgaard, A-S, Kezic, S, Jakasa, I, Engebretsen, K A, Maibach, H, and Thyssen, J P

Abstract

Patients with atopic dermatitis have skin barrier impairment in both lesional and non-lesional skin. They are typically exposed to emollients daily and topical anti-inflammatory medicaments intermittently, hereby increasing the risk of developing contact allergy and systemic exposed to chemicals ingredients found in these topical preparations. We systematically searched for studies that investigated skin absorption of various penetrants, including medicaments, in atopic dermatitis patients, but also animals with experimentally induced dermatitis. We identified 40 articles, i.e. 11 human studies examining model penetrants, 26 human studies examining atopic dermatitis drugs and 3 animal studies. We conclude that atopic dermatitis patients have nearly two-fold increased skin absorption when compared to healthy controls. There is a need for well-designed epidemiological and dermato-pharmacokinetic studies that examine to what extent atopic dermatitis patients are systemically exposed to chemicals compared to non-atopics. This article is protected by copyright. All rights reserved.

Published
2017

146. Dermatopharmacology

Author

Schaefer, H., Maibach, H., Frosch, P., Orfanos, Constantin E., editor, Stadler, Rudolf, editor, and Gollnick, Harald, editor

Published
1988
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