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102. Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center

Author

Pace Andrea, Mansueto Giovanni, Lanzetta Gaetano, Russillo Michelangelo, Moscetti Luca, Telera Stefano, Bria Emilio, Mirri Alessandra, Metro Giulio, Felici Alessandra, Fabi Alessandra, Maschio Marta, Vidiri Antonello, Sperduti Isabella, Cognetti Francesco, and Carapella Carmine M

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To evaluate the therapeutic strategies commonly employed in the clinic for the management of brain metastases (BMs) and to correlate disease outcome with type of treatment and therapeutic resources available at the treating center. Methods Four Cancer centres participated to the survey. Data were collected through a questionnaire filled in by one physician for each centre. Results Clinical data regarding 290 cancer patients with BMs from solid tumors were collected. Median age was 59 and 59% of patients had ≤ 3 brain metastases. A local approach (surgery and stereotactic radiosurgery) was adopted in 31% of patients. The local approach demonstrated to be superior in terms of survival compared to the regional/systemic approach (whole brain radiotherapy and chemotherapy, p = Conclusions In clinical practice, local strategies should be integrated in the management of brain metastases. Proper selection of patients who are candidate to local treatments is of crucial importance.

Published
2011
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103. Mental pain and pain-proneness in patients with migraine: results from the PAINMIG cohort-study

Author

Cosci, Fiammetta, Svicher, Andrea, Mansueto, Giovanni, Benemei, Silvia, Chiarugi, Alberto, De Cesaris, Francesco, Guidi, Jenny, and Zipfel, Stephan

Abstract

AbstractBackgroundPain has been qualified under four categories: nociception, perception of pain, suffering, and pain behaviors. Most of the literature on migraine has devoted attention to the first two. The aim of the present cohort study was to investigate patients with migraine enrolled at a tertiary care unit to study suffering and mental pain and identify potential risk factors for migraine.MethodsAn observational cross-sectional study was carried out on patients with chronic migraine (CM) and episodic migraine (EM), and healthy subjects (HS). The three groups were matched for age and sex. A comprehensive assessment of migraine disability, pain, psychiatric disorders, psychosomatic syndromes, depressive and anxious symptoms, euthymia, psychosocial variables, mental pain, and pain-proneness (PP) was performed.ResultsThree hundred subjects were enrolled (100 CM, 100 EM, and 100 HS). Based on the multiple regression analyses, those presenting PP (social impairment: odds ratio [OR] = 3.59, 95% confidence interval [CI] = 1.14-11.29; depressive symptoms: OR = 3.82, 95% CI = 1.74-8.41) were more likely to be CM than HS. Those with higher levels of PP (social impairment: OR = 4.04, 95% CI = 1.60-10.22; depressive symptoms: OR = 2.02, 95% CI = 1.26-3.24) were more likely to be EM than HS. Those presenting higher levels of mental pain were more likely to be CM than EM (OR = 1.45, 95% CI = 1.02-2.07).ConclusionMigraine is an unpleasant sensory and emotional experience associated with psychosocial manifestations that might contribute to the level of suffering of the individuals. Mental pain resulted to be the variable that most differentiated patients with CM from EM.

Published
2021
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106. Corrigendum: Natural History of Non-Small-Cell Lung Cancer with Bone Metastases

Author

Santini, Daniele, Barni, Sandro, Intagliata, Salvatore, Falcone, Alfredo, Ferraù, Francesco, Galetta, Domenico, Moscetti, Luca, La Verde, Nicla, Ibrahim, Toni, Petrelli, Fausto, Vasile, Enrico, Ginocchi, Laura, Ottaviani, Davide, Longo, Flavia, Ortega, Cinzia, Russo, Antonio, Badalamenti, Giuseppe, Collovà, Elena, Lanzetta, Gaetano, Mansueto, Giovanni, Adamo, Vincenzo, De Marinis, Filippo, Satolli, Maria Antonietta, Cantile, Flavia, Mancuso, Andrea, Tanca, Francesca Maria, Addeo, Raffaele, Russano, Marco, Sterpi, Michelle, Pantano, Francesco, Vincenzi, Bruno, and Tonini, Giuseppe

Subjects
Adult, Aged, 80 and over, Male, Lung Neoplasms, Bone Neoplasms, Middle Aged, Corrigenda, Article, Young Adult, Carcinoma, Non-Small-Cell Lung, Disease Progression, Humans, Female, Aged
Abstract

We conducted a large, multicenter, retrospective survey aimed to explore the impact of tumor bone involvement in Non-Small Cell Lung Cancer.Data on clinical-pathology, skeletal outcomes and bone-directed therapies for 661 deceased patients with evidence of bone metastasis were collected and statistically analyzed. Bone metastases were evident at diagnosis in 57.5% of patients. In the remaining cases median time to bone metastases appearance was 9 months. Biphosphonates were administered in 59.6% of patients. Skeletal-related events were experienced by 57.7% of patients; the most common was the need for radiotherapy. Median time to first skeletal-related event was 6 months. Median survival after bone metastases diagnosis was 9.5 months and after the first skeletal-related event was 7 months. We created a score based on four factors used to predict the overall survival from the diagnosis of bone metastases: age >65 years, non-adenocarcinoma histology, ECOG Performance Status >2, concomitant presence of visceral metastases at the bone metastases diagnosis. The presence of more than two of these factors is associated with a worse prognosis.This study demonstrates that patients affected by Non-Small Cell Lung Cancer with bone metastases represent a heterogeneous population in terms of risk of skeletal events and survival.

Published
2016

108. The Role of Anxiety Sensitivity and Expectancy Manipulation on Panic-Like Response to the 35% CO2 Challenge in Healthy Subjects.

Author

Cosci, Fiammetta, Bertoli, Giuly, Mansueto, Giovanni, Asiaghi, Martina, Schruers, Koen, and Nardi, Antonio E.

Subjects
ANXIETY sensitivity, SYSTOLIC blood pressure, HYPERTENSION, BLOOD pressure, PANIC attacks, AGORAPHOBIA
Abstract

Background: The 35% CO2 challenge is a well-established method triggering panic attacks under laboratory-controlled conditions. There is an ongoing debate whether single or the joined effects of the instructional set and anxiety sensitivity (AS) can alter the outcome of the challenge. Objectives: The present study investigated the effects of instruction manipulation and AS on panic-like response to the 35% CO2 challenge. Methods: Eighty healthy subjects, with high or low levels of AS, were randomized into 4 groups based on standard/manipulated instructional sets as well as 35% CO2 mixture/room air inhalation. Subjects filled in the Visual Analogue Scale of Anxiety (VAAS), the Visual Analogue Scale of Fear (VAS-F), the VAS of Discomfort (VAS-D), and the Panic Symptom List (PSL). Blood pressure and heart rate were measured at pre- and posttest. Results: Hierarchical multiple regression analyses showed greater psychological responses at VAAS, VAS-F, VAS-D, and PSL and higher systolic blood pressure under 35% CO2 challenge if compared to room air inhalation while instructional set and AS did not influence the response. Conclusions: The present study confirms that neither instructional test nor AS alter the outcome of the 35% CO2 challenge. [ABSTRACT FROM AUTHOR]

Published
2019
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109. Metacognitive beliefs and childhood adversities: an overview of the literature.

Author

Mansueto, Giovanni, Caselli, Gabriele, Ruggiero, Giovanni Maria, and Sassaroli, Sandra

Subjects
*CHILD abuse, *COGNITIVE testing, *EMOTIONS, *HEALTH attitudes, *MEDLINE, *ONLINE information services, *SYSTEMATIC reviews, *ADVERSE childhood experiences
Abstract

Within the Self-Regulatory Executive Function theory, emerging data suggest that unhelpful metacognitive beliefs might be associated with exposure to early adversities, however the evidence is still sparse and inconclusive. This study aimed to conduct an overview of the literature to evaluate if exposure to childhood adversities might be associated with the presence of unhelpful metacognitive beliefs. A comprehensive research was conducted on PubMed, Science Direct, Google Scholar from inception to May 2017. The search terms used were: 'childhood adversity/childhood abuse/childhood neglect/childhood loss event' AND 'metacognition/metacognitive beliefs'. A manual search of reference lists was run. Five studies were identified: three on psychiatric patients, two on the general population. Findings suggest that: (a) exposure to childhood abuse or childhood neglect might be associated with unhelpful metacognitive beliefs in adulthood; (b) early adversities are more frequently associated with negative beliefs, than other metacognitive beliefs; (c) metacognitive beliefs seem to mediate the association between childhood adversities and, repetitive thinking and negative affect. In conclusion, metacognitive beliefs might be involved in the association between early adversities and negative emotions. Interventions able to identify and reduce metacognitive beliefs associated to childhood adversities could be considered for treating the emotional consequences of childhood adversities. [ABSTRACT FROM AUTHOR]

Published
2019
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110. Correction: Corrigendum: Natural History of Non-Small-Cell Lung Cancer with Bone Metastases

Author

Santini, Daniele, primary, Barni, Sandro, additional, Intagliata, Salvatore, additional, Falcone, Alfredo, additional, Ferraù, Francesco, additional, Galetta, Domenico, additional, Moscetti, Luca, additional, La Verde, Nicla, additional, Ibrahim, Toni, additional, Petrelli, Fausto, additional, Vasile, Enrico, additional, Ginocchi, Laura, additional, Ottaviani, Davide, additional, Longo, Flavia, additional, Ortega, Cinzia, additional, Russo, Antonio, additional, Badalamenti, Giuseppe, additional, Collovà, Elena, additional, Lanzetta, Gaetano, additional, Mansueto, Giovanni, additional, Adamo, Vincenzo, additional, De Marinis, Filippo, additional, Satolli, Maria Antonietta, additional, Cantile, Flavia, additional, Mancuso, Andrea, additional, Tanca, Francesca Maria, additional, Addeo, Raffaele, additional, Russano, Marco, additional, Sterpi, Michelle, additional, Pantano, Francesco, additional, Vincenzi, Bruno, additional, and Tonini, Giuseppe, additional

Published
2016
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111. Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer

Author

Veccia, Antonello, primary, Caffo, Orazio, additional, De Giorgi, Ugo, additional, Di Lorenzo, Giuseppe, additional, Ortega, Cinzia, additional, Scognamiglio, Florinda, additional, Aieta, Michele, additional, Facchini, Gaetano, additional, Mansueto, Giovanni, additional, Mattioli, Rodolfo, additional, Procopio, Giuseppe, additional, Zagonel, Vittorina, additional, D'Angelo, Alessandro, additional, Spizzo, Gilbert, additional, Bortolus, Roberto, additional, Donini, Maddalena, additional, Lo Re, Giovanni, additional, Massari, Francesco, additional, Vicario, Giovanni, additional, Zucali, Paolo A, additional, Alesini, Daniele, additional, Bonetti, Andrea, additional, Mucciarini, Claudia, additional, Nicodemo, Maurizio, additional, Berruti, Alfredo, additional, Fratino, Lucia, additional, Lodde, Michele, additional, Messina, Caterina, additional, Perin, Alessandra, additional, Santini, Daniele, additional, Sava, Teodoro, additional, Tucci, Marcello, additional, Basso, Umberto, additional, Maines, Francesca, additional, Burgio, Luca S, additional, and Galligioni, Enzo, additional

Published
2016
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113. Natural History of Non-Small-Cell Lung Cancer with Bone Metastases

Author

Santini, Daniele, primary, Barni, Sandro, additional, Intagliata, Salvatore, additional, Falcone, Alfredo, additional, Ferraù, Francesco, additional, Galetta, Domenico, additional, Moscetti, Luca, additional, La Verde, Nicla, additional, Ibrahim, Toni, additional, Petrelli, Fausto, additional, Vasile, Enrico, additional, Ginocchi, Laura, additional, Ottaviani, Davide, additional, Longo, Flavia, additional, Ortega, Cinzia, additional, Russo, Antonio, additional, Badalamenti, Giuseppe, additional, Collovà, Elena, additional, Lanzetta, Gaetano, additional, Mansueto, Giovanni, additional, Adamo, Vincenzo, additional, De Marinis, Filippo, additional, Satolli, Maria Antonietta, additional, Cantile, Flavia, additional, Mancuso, Andrea, additional, Tanca, Francesca Maria, additional, Addeo, Raffaele, additional, Russano, Marco, additional, Sterpi, Michelle, additional, Pantano, Francesco, additional, Vincenzi, Bruno, additional, and Tonini, Giuseppe, additional

Published
2015
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114. The DSM-5 effect: psychological characteristics of new patients affected by Binge Eating Disorder following the criteria of the DSM-5 in a sample of severe obese patients

Author

Vinai, Piergiuseppe, primary, Da Ros, Annalisa, additional, Cardetti, Silvia, additional, Casey, Halpern, additional, Studt, Stacia, additional, Gentile, Nicola, additional, Tagliabue, Anna, additional, Vinai, Luisa, additional, Vinai, Paolo, additional, Bruno, Cecilia, additional, Mansueto, Giovanni, additional, Palmieri, Sara, additional, and Speciale, Maurizio, additional

Published
2015
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115. Cabazitaxel after Docetaxel in patients with metastatic, castration-resistant, prostate cancer (mCRPC): A prospective, observational study about toxicity profile and quality of life.

Author

Mansueto, Giovanni, primary, De Tursi, Michele, additional, Ratta, Raffaele, additional, Fabbri, Maria Agnese, additional, Quadrini, Silvia, additional, Salesi, Nello, additional, Rozzi, Antonio, additional, Sperduti, Isabella, additional, Ciancola, Fabrizio, additional, and Gamucci, Teresa, additional

Published
2015
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117. [Erlotinib in the treatment of NSCLC: current and novel prospects from the ASCO 2006]

Author

Flavia, Longo and Mansueto, Giovanni

Subjects
Clinical Trials as Topic, Evidence-Based Medicine, Lung Neoplasms, Smoking, Antineoplastic Agents, Adenocarcinoma, Survival Analysis, Erlotinib Hydrochloride, Sex Factors, Asian People, Carcinoma, Non-Small-Cell Lung, Quinazolines, Humans, Protein Kinase Inhibitors
Published
2006

119. Natural history of malignant bone disease in non-small cell lung cancer: Preliminary results of a multicenter bone metastasis survey.

Author

Santini, Daniele, primary, Intagliata, Salvatore, additional, Ibrahim, Toni, additional, Ferraù, Francesco, additional, Barni, Sandro, additional, Moscetti, Luca I., additional, Mansueto, Giovanni, additional, Comito, Francesca, additional, Pantano, Francesco, additional, Longo, Flavia, additional, Russo, Antonio, additional, Satolli, MAntonietta, additional, Adamo, Vincenzo, additional, La Verde, Nicla Maria, additional, Badalamenti, Giuseppe, additional, Ottaviani, Davide, additional, Ferzi, Antonella, additional, Addeo, Raffaele, additional, Vasile, Enrico, additional, and Tonini, Giuseppe, additional

Published
2013
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120. Temozolomide (TMZ) maintenance in patients with primary brain cancer treated with postoperative TMZ plus radiotherapy (RT): A retrospective analysis.

Author

Moscetti, Luca, primary, Fabbri, Maria Agnese, additional, Sperduti, Isabella, additional, Mansueto, Giovanni, additional, Fariello, Anna Maria, additional, Gamucci, Teresa, additional, Battista, Michle, additional, Loffreda, Massimiliano, additional, Pompei, Luciano, additional, and Ruggeri, Enzo, additional

Published
2012
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121. The predictive value of clinical variables in patients affected with non-small-cell lung cancer (NSCLC) treated with pemetrexed (PEM) plus platinum-based regimen: A retrospective analysis.

Author

Fabbri, Maria Agnese, primary, Moscetti, Luca, additional, Nelli, Fabrizio, additional, Gamucci, Teresa, additional, Mansueto, Giovanni, additional, Narducci, Filomena, additional, Quadrini, Silvia, additional, Sperduti, Isabella, additional, Passaro, Antonio, additional, Campenni, Giuseppe, additional, Cortesi, Enrico, additional, Martelli, Olga, additional, Bianchetti, Sara, additional, Angelini, Francesco, additional, Pellegrino, Arianna, additional, Pavese, Ida, additional, Signorelli, Carlo, additional, and Ruggeri, Enzo Maria, additional

Published
2012
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124. Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center

Author

Fabi, Alessandra, primary, Felici, Alessandra, additional, Metro, Giulio, additional, Mirri, Alessandra, additional, Bria, Emilio, additional, Telera, Stefano, additional, Moscetti, Luca, additional, Russillo, Michelangelo, additional, Lanzetta, Gaetano, additional, Mansueto, Giovanni, additional, Pace, Andrea, additional, Maschio, Marta, additional, Vidiri, Antonello, additional, Sperduti, Isabella, additional, Cognetti, Francesco, additional, and Carapella, Carmine M, additional

Published
2011
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125. Palonosetron plus 3-day aprepitant and dexamethasone to prevent nausea and vomiting in patients receiving highly emetogenic chemotherapy

Author

Longo, Flavia, primary, Mansueto, Giovanni, additional, Lapadula, Vittoria, additional, De Sanctis, Rita, additional, Quadrini, Silvia, additional, Grande, Roberta, additional, Gori, Bruno, additional, Altavilla, Amelia, additional, D’Antoni, I., additional, Del Signore, Ester, additional, Stumbo, Luciano, additional, De Luca, Cristina, additional, Cimadon, Barbara, additional, Cortesi, Enrico, additional, Gamucci, Teresa, additional, and Di Seri, Marisa, additional

Published
2010
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134. The Combination of the Selective Cyclooxygenase-2 Inhibitor Celecoxib with Weekly Paclitaxel Is a Safe and Active Second-Line Therapy for Non-Small Cell Lung Cancer

Author

Gasparini, Giampietro, primary, Meo, Sabrina, additional, Cornelia, Giuseppe, additional, Stani, Simonetta Chiara, additional, Mariani, Luigi, additional, Gamucci, Teresa, additional, Avallone, Antonio, additional, Vullo, Salvatore Lo, additional, Mansueto, Giovanni, additional, Bonginelli, Paola, additional, Gattuso, Domenico, additional, and Gion, Massimo, additional

Published
2005
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148. Second line treatment of antiangiogenic therapy with celecoxib and weekly paclitaxel for advanced non-small cell lung cancer (NSCLC)

Author

Stani, Simonetta Chiara, primary, Sarmiento, Roberta, additional, Mansueto, Giovanni, additional, Bonginelli, Paola, additional, Comella, Giovanni, additional, Ferrau, Francesco, additional, Magnani, Elena, additional, Carillio, Guido, additional, Sciacca, Venerina, additional, and Gasparini, Giampietro, additional

Published
2003
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