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The clinicopathologic characteristics of malignant lymphomas vary according to geography. The aim of this study was to determine the relative frequency of cutaneous lymphomas and to examine the clinical relevance of the WHO classification in Korean cases of cutaneous lymphoma. The Korean Dermatopathology Research Group conducted a clinicopathologic review of a nationwide collection of 80 cutaneous lymphomas, diagnosed at 23 institutes over a recent 3-year period. The clinical records, haematoxylineosin-stained slides and immunohistochemical stains from 80 patients with malignant lymphomas of the skin were reviewed. In our study, the most frequent cutaneous lymphoma was mycosis fungoides. Compared with Western countries, Korea had higher rates of NK/T cell lymphoma and subcutaneous panniculitis-like T-cell lymphoma and a much lower rate of B-cell lymphoma. The occurrence rates for various subtypes of malignant lymphoma in Korea are distinct from those in Western countries. The EORTC classification is not fully appropriate in dealing with Korean cases of cutaneous lymphoma, because NK/T cell lymphoma is not included in the EORTC classification for cutaneous lymphoma.

Posterior polar cataracts are relatively uncommon yet they pose a significant challenge to the cataract surgeon. Cataract surgery in these cases is frequently accompanied by a high incidence of posterior capsule rupture (PCR). Posterior polar cataracts are associated with remnants of the hyaloid system or the tunica vasculosa lentis.1 These cataracts may also occur without any relation to hyaloid remnants and appear as circular or rosette shaped opacities; they are hereditary and usually transmitted as a dominant trait. The gene for this has been mapped to chromosome 16q22.2 See Table 1 and Figure 1. View this table: Table 1 Classification of posterior polar cataracts Figure 1 (A) One spot polar cataract. (B) Onion polar cataract. (C) Polar cataract with hole in posterior capsule. (D) Polar cataract with nuclear sclerosis. The incidence of posterior polar cataracts in our centre is approximately 5 per 1000. …

Disseminated microsporidiosis is diagnosed uncommonly in patients not infected with human immunodeficiency virus (HIV). We present a case of disseminated microsporidiosis in a renal transplant recipient who was seronegative for HIV. Chromotrope-based stains were positive for microsporidia in urine, stools, sputum, and conjunctival scrapings. Electron microscopy, immunofluorescence, polymerase chain reaction, and cultures of renal tissue identified the organism as Encephalitozoon cuniculi. The patient was treated with oral albendazole and topical fumagillin with clinical improvement. In addition, she underwent a transplant nephrectomy and immunosuppressive therapy was withdrawn. Follow-up samples were negative for microsporidia. However, the patient developed central nervous system manifestations and died. An autopsy brain tissue specimen demonstrated E. cuniculi by immunofluorescent staining. Disseminated microsporidiosis must be considered in the differential diagnosis of multiorgan involvement in renal allograft recipients.

While GdBa2Cu3O7 − δ (GdBCO) coated conductors (CCs) have been proposed for superconducting applications, they have not been used in devices with persistent current mode (PCM) operation because of a lack of joining techniques. A superconducting joint of CCs, formed via melting diffusion and oxygenation annealing, offers no electrical resistance between the CCs, thus establishing a superconducting closed loop for PCM operation. Because superconductivity degrades with oxygen out-diffusion during melting diffusion, oxygenation annealing allows oxygen diffusion into the GdBCO lattices. As effective oxygenation annealing requires oxygen pathways in the joint, low solubility and diffusivity of oxygen in the buffer and CC substrate hinder full superconductivity recovery. Here we show a laser-drilling technique to produce microholes as conduits on the surfaces of GdBCO CCs' to promote oxygen in-diffusion, which resulted in reduced superconductivity recovery time. Superconductivity was fully recovered after laser drilling, melting diffusion at 850 °C for 1 min, and oxygenation annealing at 500 °C for 350 h.

Variations in practice patterns are markers for the quality of patient care in general medicine, but little is known about variation in care delivered to cancer patients. This study's purpose was to describe chemotherapy use, variations in chemotherapy delivery, and the incidence of complications in community practice settings.Data describing adjuvant chemotherapy for patients with early-stage breast carcinoma (ESBC) were collected from an ongoing Oncology Practice Pattern Study at 13 large managed care, academic, and community practices (1111 patients). Data collection included information about diagnoses and adjuvant chemotherapy treatments, laboratory results, supportive care, complications, and treatment modifications.The median patient age was 50 years, and most patients had zero to three positive lymph nodes. Chemotherapy regimens consisting of cyclophosphamide, methotrexate, and 5-fluororacil (CMF) and of doxorubicin and cyclophosphamide (AC) accounted for 76% of the adjuvant therapies used. Overall, 30% of patients had delivered average relative dose intensities/= 85% of the referenced targets. Delivered summation dose intensities (SDIs) frequently were well below targeted SDIs. Neutropenia-related dose modifications occurred for 27.6% of patients and recurred with a 60.7% rate. AC was the regimen delivered with a dose intensity closest to the referenced target. However, patients who were treated with AC regimens and with regimens consisting of cyclophosphamide, doxorubicin, and 5-fluorouracil had significantly higher rates of chemotherapy-related complications compared with patients who were treated with CMF regimens in the most recent treatment years.Adjuvant chemotherapy for patients with ESBC frequently is not administered as referenced in off-protocol community settings. Variation in the delivered SDI raises concerns about potential treatment outcomes and warrants strategies to identify patients who are at risk for complications early in therapy.

Records from 653 patients treated between 1991 and 1998 in the Oncology Practice Patterns Study (OPPS) were analyzed to determine contemporary chemotherapy delivery patterns in patients with intermediate-grade non-Hodgkin's lymphoma (NHL). Of the 653 patient records reviewed, 90 (14%) omitted an anthracycline or mitoxantrone (Novantrone) from primary therapy. Among patients receiving CHOP (cyclophosphamide [Cytoxan, Neosar], doxorubicin HCl, vincristine [Oncovin], prednisone) or CNOP (cyclophosphamide, mitoxantrone, vincristine, prednisone), 134 (27%) of 492 received an average relative dose intensity of less than 80% of the literature-referenced dose, due either to an inadequate planned or delivered dose. Of 181 advanced-stage patients with responsive disease, 28 (15%) failed to receive at least six treatment cycles. Overall, 283 (43%) of 653 patients potentially received suboptimal chemotherapy due either to choice of regimen or chemotherapy delivered. Patient ageor = 65 years and cardiac comorbidity appeared to have the greatest influence on a physician's decision regarding chemotherapy administration. Among the 492 patients who received CHOP or CNOP, 235 (48%) experienced a delay or reduction in chemotherapy dose (usually neutropenia-related), 100 (20%) developed mucositis, and 116 (24%) were hospitalized for febrile neutropenia. Growth factor was administered to 261 patients (53%), and its primary prophylactic use was associated with a significant reduction in the incidence of hospitalizations for febrile neutropenia in all patient subgroups receiving appropriate chemotherapeutic dose intensity (P = .02). This assessment of chemotherapy delivery to patients with intermediate-grade NHL showed significant variation from current standards. Further analysis of factors influencing chemotherapy delivery might improve therapeutic outcomes.

One of the pathophysiological features of Alzheimer's disease is astrocytosis around senile plaques. Reactive astrocytes may produce proinflammatory mediators, nitric oxide, and subsequent reactive oxygen intermediates such as peroxynitrites. In the present study, we investigated the possible role of the C-terminal fragment of amyloid precursor protein (CT-APP), which is another constituent of amyloid senile plaque and an abnormal product of APP metabolism, as an inducer of astrocytosis. We report that 100 nM recombinant C-terminal 105 amino acid fragment (CT105) of APP induced astrocytosis morphologically and immunologically. CT105 exposure resulted in activation of mitogen-activated protein kinase (MAPK) pathways as well as transcription factor NF-kappaB. Pretreatment with PD098059 and/or SB203580 decreased nitric oxide (NO) production and nuclear factor-kappa B (NF-kappaB) activation. But inhibitors of NF-kappaB activation did not affect MAPKs activation whereas they abolished NO production and attenuated astrocytosis. Furthermore, conditioned media derived from CT105-treated astrocytes enhanced neurotoxicity and pretreatment with NO and peroxynitrite scavengers attenuated its toxicity. These suggest that CT-APP may participate in Alzheimer's pathogenesis through MAPKs- and NF-kappaB-dependent astrocytosis and iNOS induction.

Renal angiomyolipoma is a benign tumor histologically characterized by proliferation of spindle cells, epithelioid cells, and adipocytic cells in concert with many thick-walled blood vessels. To add further diagnostic confusion, an epithelioid cell-predominant variant of renal angiomyolipoma has recently been described. HMB-45 immunoreactivity correlates with ultrastructural striated organelles that closely resemble premelanosomes, although no evidence of melanogenesis has been documented in this tumor.To further characterize the immunophenotypic and ultrastructural profile of renal angiomyolipoma based on phenotypic cell type (epithelioid, spindle, and adipocytic cell).Formalin-fixed, paraffin-embedded tissues from 27 renal angiomyolipomas and 8 renal cell carcinomas were immunostained with monoclonal antibodies to the melanoma-associated antigens HMB-45, HMB-50, NKI/C3 (CD63), and tyrosinase; the smooth muscle-related antigens calponin and muscle-specific actin (HHF-35); S100; and cytokeratin (CK). All renal angiomyolipomas were also immunostained with a polyclonal antibody to renin. Ultrastructural examination was performed on 9 selected cases.All renal angiomyolipomas stained positive for HMB-45, HMB-50, NKI/C3, muscle-specific actin (HHF-35), and calponin. Overall, HMB-45, HMB-50, and NKI/C3 preferentially stained the epithelioid cells. Tyrosinase staining was present in 50% of the renal angiomyolipomas with adequate tissue for staining (12 of 24 cases); positive staining and intensity paralleled HMB-45, HMB-50, and NKI/C3. Muscle-specific actin (HHF-35) and calponin preferentially stained the spindle cells. The adipocytic cells stained positive for both melanoma-associated antigens and smooth muscle antigens. Epithelioid cells, spindle cells, and adipocytic cells were CK, S100, and renin negative. Ultrastructural findings paralleled immunohistochemical staining patterns. Premelanosome-like organelles and electron dense granules were more readily detected in the epithelioid cells within the tumor, whereas ultrastructural characteristics of smooth muscle cells were more easily found in the spindle cells. All renal cell carcinomas stained positive for CK, NKI/C3 staining was variable, and all were negative for HMB-45, HMB-50, smooth muscle actin (HHF-35), and calponin.In renal angiomyolipoma, the epithelioid and spindle cells have preferential staining patterns for melanoma-associated antigens versus smooth muscle antigens, respectively. Positivity in renal angiomyolipoma for HMB-50, NKI/C3, and tyrosinase, in addition to HMB-45, provides evidence for the presence of different melanoma-associated gene products. Immunophenotypic overlap of the 3 histologically distinct renal angiomyolipoma cell populations suggests a common cell line, supporting a unitarian concept for renal angiomyolipoma. Ultrastructural characteristics of the 3 renal angiomyolipoma cell phenotypes parallel the immunophenotype, giving further support to a common cell line. Our study lends further credence to the perivascular epithelioid cell concept as proposed by Bonetti and colleagues.

Diltiazem hydrochloride is a widely used calcium channel blocking agent. While a few cases of diltiazem-associated photosensitivity have been reported, no cases of photodistributed hyperpigmentation are known.Four cases of photodistributed hyperpigmentation associated with the long-acting formulation of diltiazem hydrochloride (Cardizem CD) are presented. All patients were African American women, with a mean age of 62 years. The mean duration of diltiazem administration prior to the development of hyperpigmentation was 8 months. The hyperpigmentation was slate-gray and reticulated. Phototesting during diltiazem therapy revealed a decreased minimal erythema dose to UV-A in 1 patient. Histopathologic examination showed lichenoid dermatitis with prominent pigmentary incontinence. Electron microscopic examination of the tissue revealed multiple melanosome complexes. Discontinuation of diltiazem therapy resulted in the gradual resolution of the hyperpigmentation.Long-term administration of diltiazem may be associated with characteristic reticulated, slate-gray hyperpigmentation on sun-exposed areas. Discontinuation of the therapy results in resolution of the eruption.

We have designed and fabricated a photocathode test-stand in order to develop the polarized electron source in Korea. The test-stand consists of a photocathode gun, a light source, a cylindrical condenser and a mini-Mott chamber. We report the status of the test-stand and the future plan for the development of a polarized electron source.

The molecular pathogenesis of malignant appendageal tumors is poorly understood. Immunohistochemical staining, polymerase chain reaction (PCR)-based loss of heterozygosity (LOH) and sequencing analyses were performed in a mixed group of 21 sweat gland carcinomas. LOH was mostly confined to the chromosome arm 17p. None of the remaining 17 tumors showed LOH at any loci. Nuclear accumulation of p53 protein was observed in 3 tumors, all of which also showed LOH of 17p. One eccrine gland adenocarcinoma showed allelic loss of 17p and a Cys 176 Arg mutation in the p53 gene. The other three tumors that showed LOH of 17p, however, had wild-type p53 genes. A clear transition from benign eccrine poroma to porocarcinoma that was associated with p53 protein stabilization and allelic loss was observed in one tumor. One eccrine porocarcinoma/undifferentiated adnexal carcinoma showed prominent microsatellite instability, probably reflecting an underlying defect in DNA mismatch repair. Overexpression of erbB-2 was observed in three tumors. The low frequencies of LOH and p53 alterations in sweat gland carcinomas contrasted with the multiple genetic defects normally observed in cutaneous squamous cell carcinomas, and may be partly explained by the relative protection of cutaneous appendages from ultraviolet light and other environmental mutagens.

The recently proposed discrete scale invariance and its associated log-periodicity are an elaboration of the concept of scale invariance in which the system is scale invariant only under powers of specific values of the magnification factor. We report on the discovery of a novel mechanism for such log-periodicity relying solely on the manipulation of data. This ``synthetic'' scenario for log-periodicity relies on two steps: (1) the fact that approximately logarithmic sampling in time corresponds to uniform sampling in the logarithm of time; and (2) a low-pass-filtering step, as occurs in constructing cumulative functions, in maximum likelihood estimations, and in de-trending, reddens the noise and, in a finite sample, creates a maximum in the spectrum leading to a most probable frequency in the logarithm of time. We explore in detail this mechanism and present extensive numerical simulations. We use this insight to analyze the 27 best aftershock sequences studied by Kisslinger and Jones [1991] to search for traces of genuine log-periodic corrections to Omori's law, which states that the earthquake rate decays approximately as the inverse of the time since the last main shock. The observed log-periodicity is shown to almost entirely result from the ``synthetic scenario'' owing to the data analysis. From a statistical point of view, resolving the issue of the possible existence of log-periodicity in aftershocks will be very difficult as Omori's law describes a point process with a uniform sampling in the logarithm of the time. By construction, strong log-periodic fluctuations are thus created by this logarithmic sampling., LaTeX, JGR preprint with AGU++ v16.b and AGUTeX 5.0, use packages graphicx, psfrag and latexsym, 41 eps figures, 26 pages. In press J. Geophys. Res

Churg Strauss granuloma (cutaneous extravascular necrotizing granuloma) is a distinct entity which is associated with systemic immunoreactive or autoimmune diseases in a majority of cases. Typically, Churg Strauss granuloma presents as symmetrical papules or nodules on the extremities. There are two histological patterns: the classic pattern reveals palisading granuloma with central degenerated collagen, interspersed polymorphonuclear leukocytes, and leukocytoclastic debris; the focal basophilic necrosis pattern does not show palisading granuloma. We report two cases of Churg Strauss granuloma with different histopathological patterns.

To help understand the pathogenesis of herpes family virus ocular infection among patients positive for HIV, the authors compared the rates of detection of herpes family virus DNA from the conjunctiva of patients who are positive and negative for human immunodeficiency virus (HIV) using the polymerase chain reaction (PCR).Cross-sectional study.The conjunctival scrapings of 30 patients positive for HIV and 30 patients negative for HIV were examined.PCR was used to assay for the presence of herpes simplex virus type 1 (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) DNA (n = 240 samples).The rate of detection of virus DNA in the two groups, controlling for age, gender, and race, was measured.HSV and VZV DNA were not detected in any of the HIV-positive or HIV-negative samples. CMV DNA was detected in 20% (6 of 30) of patients positive for HIV and was undetected in control subjects negative for HIV (P = 0.01). EBV DNA was detected in 40% (12 of 30) of patients positive for HIV and in 47% (14 of 30) of control subjects negative for HIV (P = 0.58).There was no difference in the frequency of detection of HSV, VZV, or EBV DNA from the conjunctiva of patients positive or negative for HIV. Only CMV DNA was detected at a significantly higher rate in the conjunctiva of patients positive for HIV compared with control subjects negative for HIV. These different rates of peripheral virus shedding may be one possible explanation for the different rates of clinical infection among the herpes family viruses among patients positive for HIV.

We report the case of a 31-year-old woman with a rare presentation of syringoma resembling confluent and reticulated papillomatosis of Gougerot-Carteaud. The lesions have been unresponsive to treatment with topical steroids and retinoic acid.

Abundant granular eosinophilic cytoplasm is a common feature of renal oncocytoma, chromophobe renal cell carcinoma, eosinophilic variant of papillary renal cell carcinoma, and the granular variant of clear cell renal cell carcinoma (RCC). Each of these entities has a unique architectural pattern and a distinctive molecular or cytogenetic profile. The chief reason for their distinction from one another is the difference in their biologic behavior. Careful and thorough light microscopic examination distinguishes most cases based on individual characteristic architectural and cytomorphologic features. However, precise characterization may be difficult in some cases because of overlapping morphologic features. We evaluated the antimitochondrial antibody 113-1 in an attempt to ascertain differences in immunostaining patterns in 57 cases of granular renal tumors, including 20 renal oncocytomas, 15 chromophobe RCCs, 13 granular variants of clear cell RCC, and nine eosinophilic variants of papillary RCC. Distinctive, and nearly exclusive, staining patterns were observed among the groups, with chromophobe RCC showing peripheral accentuation of coarse cytoplasmic granules (15 of 15), renal oncocytoma with diffuse and fine granularity (20 of 20), and granular variant of clear cell RCC with irregular cytoplasmic distribution of coarse granules (11 of 13). Staining was most intense in the eosinophilic variant of papillary RCC and was generally coarsely granular and diffuse. Staining patterns also differed in clear cell areas within chromophobe RCC and the granular variant of clear cell RCC. Although clear cells in the former group showed granular staining with peripheral accentuation, most of the clear cells in the latter lacked any staining. We conclude that, in addition to distinct cytoarchitectural features, immunostaining patterns with antimitochondrial antibody 113-1 appear to be a useful discriminatory adjunct in the complex differential diagnosis of granular renal cell tumors.

The objective of this study was to determine whether a low dose of ACTH (0.2 microg/kg) improves the sensitivity of ACTH testing in detecting hypothalamic-pituitary-adrenal (HPA) axis abnormalities in survivors of childhood brain and skull-based tumors. Twenty-two children who had undergone treatment for brain or skull-based tumors were enrolled in a prospective study to extensively evaluate the HPA axis. Five tests of the adrenal axis were evaluated in each patient, including determination of basal serum cortisol, a standard ACTH test (250-microg i.v. bolus), a low dose ACTH test (0.2 microg/kg i.v. bolus), an insulin tolerance test, and a single dose metyrapone test. Cortisol responses to both ACTH tests were nearly identical. Two patients (9%) failed the low dose ACTH test, whereas three (14%) failed the standard ACTH test; five of the children (23%) failed the insulin tolerance test, and five (23%) had abnormal responses to metyrapone. One child who initially passed the metyrapone test failed the test 19 months later after becoming symptomatic. All children with abnormal metyrapone test results had low levels of basal cortisol secretion. In this study, the low dose ACTH test did not improve the sensitivity of ACTH testing for evaluation of the HPA axis. We conclude that a single morning basal cortisol level is a good screen for testing the HPA axis in children. We recommend confirming HPA axis dysfunction with the single dose metyrapone test, although this test also has limitations.

본 연구에서는 방사선생물 분야에서는 사용하는 세슘-137 조사기에 대한 기준 흡수선량을 측정하고 시료의 방사선량 평가에 활용하기 위하여 유리선량계를 교정하였다. 세슘-137 감마선에 대하여 IAEA TRS-277 프로토콜을 적용하여 정밀하게 물흡수선량을 결정하였다. 기준 흡수선량 측정에는 PTW-TM300013 전리함과 PTW-TM41023 물팬텀을 사용하였으며, 유리선량계는 DoseAce사의 GD-302M 모델을 사용하였다. 교정된 유리선량계의 불확도(1 SD)는 약 2.7%로 평가되며, 본 결과는 연구용 시료의 방사선량 측정에 이용될 예정이다. 【In this research, the glass dosimeter was calibrated to measure the standard absorbed dose of the Cs-137 irradiator and absorbed dose in a biological sample. Absorbed dose in water for Cs-137 gamma ray was determined by the IAEA TRS-277 protocol. The PTW-TM30013 ion chamber and the PTW-TM41023 water phantom were utilized for measuring absorbed dose and the value was compared with the reading from DoseAce GD-302M glass dosimeter from Asahi Techno Glass Corporation for its calibration. The uncertainty of measurement ( $1{\sigma}$ ) of the calibrated glass dosimeter was 2.7% and this result would be applied to improve the accuracy in measurement of absorbed dose in a biological sample.】

Agonist-stimulated phospholipid turnover can generate diacylglycerol (DAG), an intracellular second messenger that activates protein kinase C (PKC). DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. In vascular smooth muscle, agonist-stimulated DAG accumulation is biphasic; PIP2 hydrolysis produces a transient increase in DAG, which is followed by a sustained phase of DAG accumulation from PC degradation. Metabolism of DAG attenuates PKC activation and thus results in signal termination. The metabolic fates for DAG include 1) ATP-dependent phosphorylation to form phosphatidic acid (DAG kinase), 2) hydrolysis to release fatty acids and glycerol (DAG and monoacylglycerol lipases), 3) synthesis of triacylglycerol (DAG acyltransferase), and 4) synthesis of PC (choline phosphotransferase). Hydrolysis through the lipase pathway is the predominant metabolic fate of DAG in vascular smooth muscle. Activation of PKC in vascular smooth muscle modulates agonist-stimulated phospholipid turnover, produces an increase in contractile force, and regulates cell growth and proliferation. Further research is required to investigate cross talk between signal transduction mechanisms involving lipid second messengers. In addition, spatial considerations such as nuclear PKC activation and the influence of diradylglycerol generation on the duration of PKC activation are important issues.

Vertical seismic profile (VSP) experiments were conducted during 1986–1987 at the Bekes-2 well site, where the well penetrated 2161 m of Mesozoic carbonate rocks beneath basin fill (TD = 5500 m). For these experiments a vertical-component, wall-locking geophone was used. Energy was generated by an explosive source for one near-offset and two far-offset VSP experiments, and by a Vibroseis source for a walk-away VSP experiment. These sets of VSP data were analyzed in conjunction with a seismic reflection profile recorded on the ground surface.

e16639 Background: Few reports have focused on global changes in cancer care. The objective of this study is to assess changes in first line therapy of NS NSCLC following publication of phase 3 dat...

The regulatory effects of diacylglycerol (DAG) second messengers will be terminated by metabolism. A long-chain DAG, 1-palmitoyl-2-[1-14C]oleoyl-sn-glycerol (2-[14C]POG), was metabolized by cultured A10 smooth muscle cells after permeabilization by preincubation with 340 U/ml alpha-toxin from Staphylococcus aureus. In contrast to results with the cell-permeable DAG analogue, dioctanoyl-glycerol ([3H]diC8), no appreciable 2-[14C]POG degradation could be detected in control A10 cells not treated with alpha-toxin. With permeabilized A10 cells, 2-[14C]POG was mainly converted into lipolytic products of a lipase pathway, monoacylglycerol (MG) and fatty acid (FA); very little radioactivity was incorporated into triacylglycerol (TG) or phospholipid (PL) via reactions catalyzed by either DAG acyltransferase, cholinephosphotransferase, or DAG kinase. Similar results were obtained in experiments with 1-stearoyl-2-[1-14C]arachidonoyl-sn-glycerol. The conversion of 2-[14C]POG into PL and TG was not enhanced by the addition of 1 mM ATP-MgCl2, 1 mM CDP-choline, or 1 mM oleoyl-CoA to the alpha-toxin-treated A10 cells. The formation of FA and MG by permeabilized A10 cells was inhibited by DAG lipase inhibitors, U-57,908 (50 microM) and tetrahydrolipstatin (1-25 nM). The predominant contribution of the lipase pathway to the metabolism of a long-chain DAG, 2-[14C]POG, by alpha-toxin-treated A10 cells is similar to results for the degradation of [3H]diC8 by intact A10 cells.

The safety of liposuction surgery begins with appropriate preoperative evaluation and patient selection. Operative considerations include the type of anesthesia used, the volume of fat aspirated, and the liposuction technique utilized. Results from a recent survey revealed that liposuction surgery can be extremely safe when done under local anesthesia with conservative fat removal.

As animating objects is becoming very popular in many applications, there is an increasing need to directly manipulate objects when generating an animation sequence. While manipulating objects, it will be indispensable to compare the difference in motion of the objects so that the validity of motion can be investigated. Motion comparison provides the basis to realize an object-oriented computer animation system with a reliable function to control the movement of objects. This paper presents an algorithm for motion comparison in a 4D environment, based on the construction of a motion-specific object coordinate system for each object.

Lee M-W, Muramatsu T, Uekusa T, Lee J-H, Shimono M. Heat stress induces alkaline phosphatase activity and heatshock protein 25 expression in cultured pulp cells. InternationalEndodontic Journal, 41, 158–162, 2008. Aim To investigate the responses of cultured rat pulpcells to heat stress.Methodology Pulp cells were obtained from ratincisors and cultured at 37 C. The cells were culturedat 42 C for 30 min and then cultured at 37 C again.Morphology, alkaline phosphatase (ALP) activity andexpression of heat shock protein 25 (HSP25) wereinvestigated at 0, 1, 3, 5, 7, 10 and 14 days followingstimulation. As a control, the cells were maintained at37 C.Results Although there were few cells of apoptosisimmediately after heat stress, there were mitotic cellsfrom day 1 after heat stress. ALP activity in the heatstress group significantly increased at days 7 and 14compared with the control group (about 1.7-fold,P < 0.01, Friedman test). HSP25 expression increasedin both groups, with HSP25 in the heat stress groupbeing expressed earlier than in the control group, andnuclear localization of HSP25 was observed at days 0and 1 in heat-stressed cells.Conclusion These results suggest that heat stressnot only induces HSP25 but also enhances ALP activityin pulp cells.Keywords: alkaline phosphatase activity, dentalpulp, heat shock protein 25, heat stress.

7005 Background: Temsirolimus (CCI-779), an ester of sirolimus, is an inhibitor of mTOR, shown to inhibit tumor cell proliferation in non-clinical models. Standard chemotherapy typically results in...

Expressions for the average channel capacity of a multiuser diversity system combined with transmit diversity at each link are presented under the assumption of independent Rayleigh fading. The analysis results exactly agree with the simulation results and definitely show the impact of transmit diversity on multiuser diversity.

We report the observation of electron cyclotron resonance (CR) in n-type CdSe with an average carrier density below the metal-insulator transition (N d1/3a * = 0.08). A plasma-shifted electron cyclotron resonance (SCR) is also observed. The number of carriers participating in cyclotron resonance, which is more than 4 orders less than N d − N a, increases rapidly with magnetic field, in agreement with a previous calculation based on Poisson distribution of donors. This supports the picture of metallic donor clusters within doped semiconductors due to random distribution of impurities. The simultaneous appearance of both CR and SCR is interpreted in terms of the breakdown of the Maxwell Garnett theory for random-donor semiconductors.

Far infrared magneto transmission measurements on n-type GaAs doped near the metal-insulator transition show evidence for the impurity ls-2p ± optical transition in both the insulating and the metallic states and no cyclotron resonance at low temperatures. The ls-2p ± absorption line-shape varies smoothly through the magnetic field induced metal-insulator transition.

Particle displacements from incident plane waves at the wall of a fluid‐filled borehole are formulated by applying the seismic reciprocity theorem to far‐field displacement fields. Such displacement fields are due to point forces acting on a fluid‐filled borehole under the assumption of long wavelengths. The displacement fields are analyzed to examine the effect of the borehole on seismic wave propagation, particularly for vertical seismic profiling (VSP) measurements. When the shortest wavelength of interest is approximately 25 times longer than the borehole’s diameter, the scattered displacements are proportional to the first power of incident frequency and borehole diameter. The maximum scattered energy occurs when an incident P‐wave propagates perpendicular to the borehole. Borehole effects on VSP measurements, such as waveform distortion, amplitude variation, and time delay, have been analyzed using the concept of a transfer function. When the shortest wavelength of interest is about 40 times longer than the borehole’s diameter, borehole effects on VSP measurements using a wall‐locking geophone are negligible.

An equilibrium isotope effect has been studied as a continuous function of the potential field acting on the atom undergoing isotopic exchange. This has been accomplished through a study of the liquid vapor isotope fractionation factors for both, 36Ar/40Ar and 80Kr/84Kr in a series of binary mixtures which span the range between the pure components at 117.5 °K. The 36Ar/40Ar fractionation factor increases (linearly) from (lnα)2.49×10−3 in pure liquid argon to 2.91×10−3 in an infinitely dilute solution in liquid krypton. Conversely, the 80Kr/84Kr fractionation factor decreases (linearly) from (lnα)0.98×10−3 in pure liquid krypton to 0.64×10−3 in an infinetely dilute solution in pure liquid argon. The mean force constants 〈∇2U〉c on both argon and krypton atoms in the mixtures are derived from the respective isotope fractionation factors. It is shown that the mean force constant on argon atoms in infinitely dilute solution in krypton is equal, within experimental error, to the mean force constant on krypton ...

Information of cryostat use and reliability was collected from 130 members of the American College of Mohs Micrographic Surgery and Cutaneous Oncology. The Damon IEC International cryostat was utilized by 38% of the survey participants, followed by the Reichert Histostat (18%) and the LabTek/TissueTek (13%). Data were also collected on methods of frozen-section embedding and technical training.

The structures of boron hydrides, B2H6, B1H10, B5H9, B5H11, B6H10, and B10H1, are interpreted as resonance hybrids of valence bond structures that only contain two—center two electron bonds. Graph—theore— tical techniques are used to count the large number of structures incor— porated in the hybrids. Calculated bond orders and charges are compared with the results of LCAO—MO—SCF calculations and with three—center valence bond models. The heats of atomization can be correlated with a 4 term linear equation based on the numbers of neighboring boron atom pairs, terminal BH bonds, bridging BH bonds, and estimates of resonance energies. Resonance energies comprise 1 1 to 29% of the atomization energies for these boron hydrides.