227 results on '"M. van der Velde"'
Search Results
102. Medium corrections to the first order optical potential for low-energy pion-4He scattering
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J. De Kam, F.M.M. van Geffen, and M. van der Velde
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Physics ,Elastic scattering ,Nuclear and High Energy Physics ,symbols.namesake ,Effective mass (solid-state physics) ,Pion ,Pauli exclusion principle ,Scattering ,Isospin ,Quantum electrodynamics ,symbols ,Residual ,Optical potential - Abstract
We study the Pauli-principle corrections for low energy π-4He elastic scattering. In our approach we take into account explicitly the spin and isospin dependence of the Pauli-principle effect. Furthermore we discuss the combined effect of the Pauli-principle correction and the nuclear binding. Contrary to the Pauli principle we treat the binding corrections in an approximate way, using an effective mass for the residual nucleus. In our calculations we use the first-order optical potential of Celenza, Liu and Shakin. The Pauli-principle correction is found to have a considerable effect on the differential cross section. Our results indicate that the Pauli-principle corrections are largely compensated by the nuclear binding.
- Published
- 1980
103. Gel electrophoresis of human tears reveals various forms of tear lactoferrin
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A Kuizenga, M. Van Der Velde, N.J. van Haeringen, and Aize Kijlstra
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Glycosylation ,Hot Temperature ,Sodium ,Immunoblotting ,chemistry.chemical_element ,Lactoglobulins ,Iron Chelating Agents ,Chromatography, Affinity ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Animals ,Humans ,Disulfides ,Polyacrylamide gel electrophoresis ,Gel electrophoresis ,Chromatography ,biology ,Chemistry ,Lactoferrin ,Binding protein ,Temperature ,Antibodies, Monoclonal ,Carbohydrate ,Sensory Systems ,Molecular Weight ,Ophthalmology ,Milk ,Tears ,biology.protein ,Electrophoresis, Polyacrylamide Gel - Abstract
Lactoferrin is a metal binding protein, which is present in high concentrations in human tears. Little is known concerning the exact molecular shape of lactoferrin in tears. Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting experiments showed that this protein is present in multiple forms in tear fluid. SDS-PAGE analysis of human tears under non reducing conditions and pretreatment of tears in sample buffer at room temperature revealed lactoferrin in a major form of 60 kD, a minor form of 64 kD and a third form of 52 kD. Pretreatment of tears at elevated temperatures prior to sample application resulted in the loss of this third form. Disruption of intrachain disulfide bridges prior to SDS-PAGE analysis resulted in a shift in the apparent molecular weight of lactoferrin to 78 kD and 83 kD for the major and minor form, respectively. Chromatography of human tears on ConA-Sepharose as well as enzymatic deglycosylation showed that the difference in molecular weight of the major and minor lactoferrin form was not due to a variation in the carbohydrate side chains. The presence of the minor form could also not be ascribed to iron saturation. Instead we found that addition of iron ions to human tears resulted in a shift of tear lactoferrin to a lower molecular weight species of about 52 kD, coinciding with the third lactoferrin form mentioned above and a small protein band of approximately 57 kD, representing the iron saturated minor lactoferrin form. Similar findings were observed using purified milk lactoferrin. Increasing the temperature prior to sample application or disruption of disulfide bridges dissociated the iron-lactoferrin complex.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1989
104. The nucleon-antinucleon interaction and resonances
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J.C.H. van Doremalen, Yu.A. Simonov, and M. van der Velde
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Physics ,Coupling ,Nuclear and High Energy Physics ,Annihilation ,Basis (linear algebra) ,Scattering ,Quantum mechanics ,Bound state ,Nuclear cross section ,Atomic physics ,Nucleon ,Charge exchange - Abstract
On the basis of a multichannel N / D formulation using the non-static Bryan and Phillips OBEP we give a detailed account of the resonances and bound states in the nucleon-antinucleon system. The theory contains two state-independent parameters: the strength of the coupling and the real over imaginary part of the annihilation interaction. We determine the exact positions of the poles by simultaneously fitting the total cross sections for elastic, charge exchange and annihilation scattering with these two parameters. The resonances we find have large widths and no resonance structure is seen in the cross sections. This suggests that the recently found N N resonances are not of a quasinuclear origin.
- Published
- 1980
105. Are there resonances in the πd system near the ΔN threshold?
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M. van der Velde and Yu.A. Simonov
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Physics ,Nuclear and High Energy Physics ,Partial width ,Amplitude ,Quantum electrodynamics ,Resonance ,Limit (mathematics) ,Atomic physics - Abstract
The comparison of forward and backward Argand diagrams (instead of partial wave Argand diagrams) provides a simple and powerful criterion to distinguish between true resonances and pseudoresonances. When applied to the elastic πd amplitude, it produces definite evidence for a pseudoresonance near the ΔN threshold and an upper limit for the partial width of a possible dibaryon resonance.
- Published
- 1978
106. Relativistic effects in deuteron alignment in πD scattering
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H. J. Boersma and M van der Velde
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Nuclear physics ,Physics ,Nuclear and High Energy Physics ,Deuterium ,Scattering ,Nuclear Theory ,General Physics and Astronomy ,Atomic physics ,Nuclear Experiment ,Relativistic quantum chemistry ,Vertex (geometry) - Abstract
The spin dependence of the total cross section for pion-deuteron scattering is calculated. Relativistic effects are introduced by the P waves of the deuteron vertex. The results indicate that these P waves play an important role even at low energies.
- Published
- 1978
107. Comment on the invalidity of the Brayshaw mechanism to generate peaks in three-hadron systems
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M. van der Velde, M.I. Polykarpov, and Faculty of Science
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Physics ,Many-body problem ,Scattering amplitude ,Theoretical physics ,Classical mechanics ,Unitarity ,Phase space ,Diagram ,Elementary particle ,Observable ,Gravitational singularity - Abstract
The recently proposed mechanism by Brayshaw is studied quantitatively. The already well-known subenergy singularities of the triangle diagram are indeed present. However, the proper unitarization of this diagram leads (in general) to no observable effects in cross sections, suggesting that no dynamical mechanism for producing three-body resonances can be associated with these singularities.
- Published
- 1980
108. Detecting indoor CO exposure by measuring CO in exhaled breath
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H. C. M. van der Velde, Arnoud P. Verhoeff, Erik Lebret, Bert Brunekreef, and Jan S.M. Boleij
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Adult ,Adolescent ,Luchtkwaliteit ,Air Quality ,Heating ,Expired air ,chemistry.chemical_compound ,Humans ,Cooking ,Child ,Household Articles ,Carbon monoxide ,Indoor pollution ,Aged ,Air Pollutants ,Smoking ,Public Health, Environmental and Occupational Health ,Vakgroep Gezondheidsleer ,Environmental Exposure ,Middle Aged ,Carboxy hemoglobin ,Environmental and Occupational Health Group ,Water heater ,Biological monitoring ,chemistry ,Breath Tests ,Carboxyhemoglobin ,Environmental chemistry ,behavior and behavior mechanisms ,Co exposure - Abstract
CO levels in exhaled breath were measured in 29 residents of flats, equipped with a flueless geiser (an instantaneous gas-fired water heater). The flats were selected because they had a geiser with a CO concentration of more than 250 parts per million in its flue gases. Small, but in some cases statistically significant increases in CO levels in exhaled breath were found in both smokers and non smokers, and after periods of cooking and dishwashing when the geisers had been used. Calculated COHb levels remained well below 2.5% for non smokers, but were generally higher for smokers.
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- 1983
109. Vegetatie en beheer van wegbermen in Groningen
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M. van der Velde and M. van der Velde
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- 1986
110. Broedpoging Buidelmees (Remiz pendulinus) in Groningen?
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P.D. Cnossen, M. van der Velde, P.D. Cnossen, and M. van der Velde
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Op 25 mei 1981 werd op een terrein nabij de stad Groningen een tweetal Buidelmezen waargenomen. Een daarvan was regelmatig actief in en op een aan een wilgetak hangend nest. Enkele weken later waren zowel de Buidelmezen als ook het nest verdwenen. Aangenomen moet worden dat de dieren niet tot broeden zijn gekomen.
- Published
- 1982
111. Self-healing dyes for super-resolution fluorescence microscopy.
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Jasper H M van der Velde, Jochem H Smit, Elke Hebisch, Michiel Punter, and Thorben Cordes
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- *
DYES & dyeing , *FLUORESCENCE microscopy , *FLUOROPHORES - Abstract
In recent years, optical microscopy techniques have emerged that allow optical imaging at unprecedented resolution beyond the diffraction limit. These techniques exploit photostabilizing buffers to enable photoswitching and/or the enhancement of fluorophore brightness and stability. A major drawback with the use of photostabilizing buffers, however, is that they cannot be used in live cell imaging. In this paper, we tested the performance of self-healing organic fluorophores, which undergo intramolecular photostabilization, in super-resolution microscopy examining both targeted (stimulated emission depletion (STED) microscopy) and stochastic readout (stochastic optical reconstruction microscopy (STORM)). The overall goal of the study was to identify dyes and conditions that lead to improved spatial and temporal resolution of both techniques without the need for mixtures of photostabilizing agents in the imaging buffer. As a result of previously shown superior performance, we identified an ATTO647N-photostabilizer conjugate as a potential candidate for STED microscopy. We have here characterized the photostability and resulting performance of this nitrophenylalanine (NPA) conjugate of ATTO647N on oligonucleotides in STED microscopy. We found that the superior photophysical performance resulted in optimal STED imaging and demonstrated that single-molecule fluorescent transients of individual fluorophores can be obtained with both the excitation- and STED-laser. In similar experiments, we also tested a nitrophenylacetic acid conjugate of STAR635P, another frequently used dye in STED microscopy, and present a characterization of its photophysical properties. Finally, we performed an analysis of the photoswitching kinetics of self-healing Cy5 dyes (containing trolox, cyclooctatetraene and NPA-based stabilizers) in the presence of Tris(2-carboxyethyl)phosphine and cysteamine, which are typically used in STORM microscopy. In line with previous work, we found that intramolecular photostabilization strongly influences photoswitching kinetics and requires careful attention when designing STORM-experiments. In summary, this contribution explores the possibilities and limitations of self-healing dyes in super-resolution microscopy of differing modalities. [ABSTRACT FROM AUTHOR]
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- 2019
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112. Erratum to: ‘Ventilator-associated Pneumonia caused by commensal oropharyngeal a retrospective Analysis of a prospectively collected Database’
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Johannes B. J. Scholte, Johan I. M. van der Velde, Catharina F. M. Linssen, Helke A. van Dessel, Dennis C. J. J. Bergmans, Paul H. M. Savelkoul, Paul M. H. J. Roekaerts, and Walther N. K. A. van Mook
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Pulmonary and Respiratory Medicine - Full Text
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113. From repository to eternity: from Delft repository to DARE - the developments of OAI in The Netherlands
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J. De Leeuwe and M. Van der Velde
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Metadata ,Engineering ,Digital preservation ,National library ,business.industry ,media_common.quotation_subject ,Technical university ,Library science ,Library and Information Sciences ,business ,Eternity ,media_common - Abstract
To meet the growing demand for accessibility of scientific output, a national-level co-operation has been established in The Netherlands to implement local repositories, known as Digital Academic REpositories (DARE). The repository content will be included in the e-Depot of the National Library of The Netherlands (KB) and therefore in their digital preservation strategies, guaranteeing the accessibility for future generations. This article presents the perspectives of both the Library of the Technical University (TU) of Delft repository and the KB on technical issues concerning harvesting metadata and establishing the infrastructure for a national digital preservation programme supported at the local level.
114. Implementation of a care-pathway at the emergency department for older people presenting with nonspecific complaints; a protocol for a multicenter parallel cohort study.
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M G A M van der Velde, M A C Jansen, M A C de Jongh, M N T Kremers, and H R Haak
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Medicine ,Science - Abstract
BackgroundOlder adults frequently attend the Emergency Department (ED) with poorly defined symptoms, often called nonspecific complaints (NSC). NSC such as 'weakness' and 'not feeling well', often lead to an extensive differential diagnosis. Patients with NSC experience a prolonged length of stay at the ED and are prone to adverse outcomes. Currently, a care pathway for patients with NSC does not exist. A special structured care pathway for patients with NSC was designed to improve the efficiency and quality of care at the ED.MethodA multicenter parallel cohort study, organized in different hospitals in the Noord-Brabant area, the Netherlands, in which general practitioners (GP), elderly care physicians (ECP), Emergency Physicians (EP), geriatricians and internists will collaborate. Patients ≥ 70 years presenting with NSC and in need of ED admission as indicated by their own GP or ECP are eligible for inclusion. Before implementation each hospital will retrospectively include their own control-group. After implementation, patients will prospectively be included. The care-pathway exists of risk stratification by the APOP-screener, in-depth history taking, i.e. limited comprehensive geriatric assessment (CGA) and a standard set of diagnostics, and a dedicated ED-nurse (if possible) present to ensure the care-pathway is followed. The primary outcome is length of stay at the ED (LOS-ED) and perceived quality of care. Secondary outcomes are hospital length of stay, revisits, readmissions and mortality at 30- and 90-day follow-up.DiscussionThis study proposes a structured care pathway for older patients presenting at the ED with NSCs and considering effectiveness and perceived quality this may improve acute care for these patients.Trial registrationDutch Trial register, number NL8960.
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- 2023
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115. Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study
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Coen D A Stehouwer, Kristiaan Wouters, Jeroen H P M van der Velde, Jos P H Reulen, Werner Mess, Casper G Schalkwijk, and Nicolaas C Schaper
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Introduction Distal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methods This cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.Results After adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.Conclusions The associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN.
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- 2021
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116. A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
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Jasper H. M. van der Velde, Jens Oelerich, Jingyi Huang, Jochem H. Smit, Atieh Aminian Jazi, Silvia Galiani, Kirill Kolmakov, Giorgos Gouridis, Christian Eggeling, Andreas Herrmann, Gerard Roelfes, and Thorben Cordes
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Science - Abstract
Synthetic organic fluorophores are powerful tools for bioimaging, but frequently display shortened observation times and signal fluctuations. Here, the authors report a general method to covalently label a biomolecule with a fluorophore and photostabilizer, reducing unwanted photophysical effects by intramolecular quenching of reactive fluorophore states.
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- 2016
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117. Correction: Author Correction: A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
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Jasper H. M. van der Velde, Jens Oelerich, Jingyi Huang, Jochem H. Smit, Atieh Aminian Jazi, Silvia Galiani, Kirill Kolmakov, Giorgos Gouridis, Christian Eggeling, Andreas Herrmann, Gerard Roelfes, and Thorben Cordes
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Science - Abstract
Nature Communications 7: Article number: 10144 (2016); Published 11 January 2016, Updated 24 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘This work was also financed by an ERC starting grant ‘SM-IMPORT’ (No. 638536 to T.C.)’. This has been corrected in both the PDF and HTML versions of the Article.
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- 2018
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118. Correction: Corrigendum: A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
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Jasper H. M. van der Velde, Jens Oelerich, Jingyi Huang, Jochem H. Smit, Atieh Aminian Jazi, Silvia Galiani, Kirill Kolmakov, Giorgos Gouridis, Christian Eggeling, Andreas Herrmann, Gerard Roelfes, and Thorben Cordes
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Science - Abstract
Nature Communications 7: Article number: 10144 (2016); Published: 11 January 2016; Updated: 16 November 2017 This Article contains an error in Fig. 4. Figure 4b shows the structure of the rhodamine dye Alexa488, not the Alexa555 used in this work. The structure of Alexa555 is not known.
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- 2017
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119. Quantifying the impact of an abrupt reduction in mineral nitrogen fertilization on crop yield in the European Union.
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Pacifico F, Ronchetti G, Dentener F, van der Velde M, van den Berg M, and Lugato E
- Abstract
Contemporary crop production in Europe relies on nitrogen (N) fertilization. Fertilizer prices soared in 2021-2022, and remained at historical high levels in 2023. These high prices invoked an immediate concern on the possible consequences for Europe's food production. In this study, we use a biogeochemical model framework to estimate the impact of reducing mineral N fertilization on crop yields in the European Union (EU). First, crop yields simulated with the biogeochemical DayCent model are evaluated against subnational yield data averaged for 2015-2018 reported by Eurostat and National Statistical Institutes in the EU for soft wheat, barley, grain maize and rapeseed. Then, we simulate three different scenarios where mineral N fertilization across the EU is abruptly reduced by respectively 5, 15 and 25 %, and compare yields to the projected baseline for contemporary conditions (2019-2022). The model evaluation gives r
2 values ranging from 0.28 (rapeseed) to 0.61 (soft wheat) and root mean square errors (RMSE) ranging from 0.6 (rapeseed) to 1.95 t ha-1 (maize). The model shows a reduction in yield per crop at the EU level up to 2.1, 6.4 and 11.2 % with the 5, 15 and 25 % reduction scenario, respectively. Different crops show different percentage reduction in yield following a reduction in mineral N fertilization, showing a legacy effect over the years and depending on the availability of organic fertilizer. The strongest relative yield reduction occurs for soft wheat for all three scenarios. Even with 25 % drop in mineral N fertilization, maize yield in the Netherlands, Belgium and Denmark is not significantly reduced, because of the high N surplus and large share of organic fertilization in these countries. This process-based modelling study provides spatially explicit, high resolution information on the response of crop yields to N fertilizer input reductions, helping policy-makers in decision-making on food security and environmentally-friendly food systems., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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120. European Union crop map 2022: Earth observation's 10-meter dive into Europe's crop tapestry.
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Ghassemi B, Izquierdo-Verdiguier E, Verhegghen A, Yordanov M, Lemoine G, Moreno Martínez Á, De Marchi D, van der Velde M, Vuolo F, and d'Andrimont R
- Abstract
To provide the information needed for a detailed monitoring of crop types across the European Union (EU), we present an advanced 10-metre resolution map for the EU and Ukraine with 19 crop types for 2022, updating the 2018 version. Using Earth Observation (EO) and in-situ data from Eurostat's Land Use and Coverage Area Frame Survey (LUCAS) 2022, the methodology included 134,684 LUCAS Copernicus polygons, Sentinel-1 and Sentinel-2 satellite imagery, land surface temperature and a digital elevation model. Based on this data, two classification layers were developed using a Random Forest machine learning approach: a primary map and a gap-filling map to address cloud-covered gaps. The combined maps, covering 27 EU countries, show an overall accuracy of 79.3% for seven major land cover classes and 70.6% for all 19 crop types. The trained model was used to derive the 2022 map for Ukraine, demonstrating its robustness even in regions without labelled samples for model training., (© 2024. The Author(s).)
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- 2024
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121. Evidence library of meta-analytical literature assessing the sustainability of agriculture - a dataset.
- Author
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Schievano A, Pérez-Soba M, Bosco S, Montero-Castaño A, Catarino R, Chen M, Tamburini G, Landoni B, Mantegazza O, Guerrero I, Bielza M, Assouline M, Koeble R, Dentener F, Van der Velde M, Rega C, Furlan A, Paracchini ML, Weiss F, Angileri V, Terres JM, and Makowski D
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- Meta-Analysis as Topic, Conservation of Natural Resources, Agriculture
- Abstract
In the last two decades, an exponentially growing number of meta-analyses (MAs) synthesize thousands of peer-reviewed studies on the environmental impacts of farming practices (FPs). This paper describes the iMAP-FP evidence library, a comprehensive dataset on the effects of 34 categories of FPs (such as agronomic practices, cropping and livestock systems, land management options and mitigation techniques) on 34 impacts including climate mitigation, soil health, environmental pollution, water use, nutrients cycling, biodiversity, and agricultural productivity. Through systematic screening, 570 MAs published since 2000 were selected and categorized according to the type of FP. We assessed their impacts, the geographic regions covered, and their quality. We extracted 3,811 effects and their statistical significance associated with sustainable FPs (intervention) compared to a control (typically conventional agriculture) across 223 different intervention-control pairs. Our dataset is accompanied with an online free-access library, which includes a catalogue of synthetic reports summarizing the available evidence on each evaluated FP., (© 2024. European Union.)
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- 2024
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122. Barriers and Facilitators to the Implementation of Digital Health Services for People With Musculoskeletal Conditions in the Primary Health Care Setting: Systematic Review.
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van Tilburg ML, Spin I, Pisters MF, Staal JB, Ostelo RW, van der Velde M, Veenhof C, and Kloek CJ
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- Humans, Telemedicine organization & administration, Musculoskeletal Diseases therapy, Primary Health Care organization & administration, Digital Health organization & administration
- Abstract
Background: In recent years, the effectiveness and cost-effectiveness of digital health services for people with musculoskeletal conditions have increasingly been studied and show potential. Despite the potential of digital health services, their use in primary care is lagging. A thorough implementation is needed, including the development of implementation strategies that potentially improve the use of digital health services in primary care. The first step in designing implementation strategies that fit the local context is to gain insight into determinants that influence implementation for patients and health care professionals. Until now, no systematic overview has existed of barriers and facilitators influencing the implementation of digital health services for people with musculoskeletal conditions in the primary health care setting., Objective: This systematic literature review aims to identify barriers and facilitators to the implementation of digital health services for people with musculoskeletal conditions in the primary health care setting., Methods: PubMed, Embase, and CINAHL were searched for eligible qualitative and mixed methods studies up to March 2024. Methodological quality of the qualitative component of the included studies was assessed with the Mixed Methods Appraisal Tool. A framework synthesis of barriers and facilitators to implementation was conducted using the Consolidated Framework for Implementation Research (CFIR). All identified CFIR constructs were given a reliability rating (high, medium, or low) to assess the consistency of reporting across each construct., Results: Overall, 35 studies were included in the qualitative synthesis. Methodological quality was high in 34 studies and medium in 1 study. Barriers (-) of and facilitators (+) to implementation were identified in all 5 CFIR domains: "digital health characteristics" (ie, commercial neutral [+], privacy and safety [-], specificity [+], and good usability [+]), "outer setting" (ie, acceptance by stakeholders [+], lack of health care guidelines [-], and external financial incentives [-]), "inner setting" (ie, change of treatment routines [+ and -], information incongruence (-), and support from colleagues [+]), "characteristics of the healthcare professionals" (ie, health care professionals' acceptance [+ and -] and job satisfaction [+ and -]), and the "implementation process" (involvement [+] and justification and delegation [-]). All identified constructs and subconstructs of the CFIR had a high reliability rating. Some identified determinants that influence implementation may be facilitators in certain cases, whereas in others, they may be barriers., Conclusions: Barriers and facilitators were identified across all 5 CFIR domains, suggesting that the implementation process can be complex and requires implementation strategies across all CFIR domains. Stakeholders, including digital health intervention developers, health care professionals, health care organizations, health policy makers, health care funders, and researchers, can consider the identified barriers and facilitators to design tailored implementation strategies after prioritization has been carried out in their local context., (©Mark Leendert van Tilburg, Ivar Spin, Martijn F Pisters, J Bart Staal, Raymond WJG Ostelo, Miriam van der Velde, Cindy Veenhof, Corelien JJ Kloek. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 27.08.2024.)
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- 2024
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123. Defining a competency framework for health and social professionals to promote healthy aging throughout the lifespan: an international Delphi study.
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Rodríguez-Monforte M, Fernández-Jané C, Bracha M, Bartoszewska A, Kozakiewicz M, Leclerc M, Nimani E, Soanvaara P, Jarvinen S, Van Sherpenseel M, van der Velde M, Alves-Lopes A, Handgraaf M, Grüneberg C, and Carrillo-Alvarez E
- Abstract
The promotion of healthy aging has become a priority in most parts of the world and should be promoted at all ages. However, the baseline training of health and social professionals is currently not adequately tailored to these challenges. This paper reports the results of a Delphi study conducted to reach expert agreement about health and social professionals' competencies to promote healthy aging throughout the lifespan within the SIENHA project. Materials and methods: This study was developed following the CREDES standards. The initial version of the competence framework was based on the results of a scoping review and following the CanMEDS model. The expert panel consisted of a purposive sample of twenty-two experts in healthy aging with diverse academic and clinical backgrounds, fields and years of expertise from seven European countries. Agreement was reached after three rounds. The final framework consisted of a set of 18 key competencies and 80 enabling competencies distributed across six domains. The SIENHA competence framework for healthy aging may help students and educators enrich their learning and the academic content of their subjects and/or programs and incentivize innovation., (© 2024. The Author(s).)
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- 2024
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124. Professional competences to promote healthy ageing across the lifespan: a scoping review.
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Carrillo-Alvarez E, Rodríguez-Monforte M, Fernández-Jané C, Solà-Madurell M, Kozakiewicz M, Głowacka M, Leclère M, Nimani E, Hoxha A, Hirvonen A, Järvinen S, van der Velde M, van Scherpenseel M, Lopes AA, Santos H, Guimarães I, Handgraaf M, and Grüneberg C
- Abstract
As societies age, the development of resources and strategies that foster healthy ageing from the beginning of life become increasingly important. Social and healthcare professionals are key agents in this process; therefore, their training needs to be in agreement with societal needs. We performed a scoping review on professional competences for social and health workers to adequately promote healthy ageing throughout life, using the framework described by Arksey and O'Malley and the Joanna Briggs Institute Guidelines. A stakeholder consultation was held in each of the participating countries, in which 79 experts took part. Results show that current literature has been excessively focused on the older age and that more attention on how to work with younger population groups is needed. Likewise, not all disciplines have equally reflected on their role before this challenge and interprofessional approaches, despite showing promise, have not been sufficiently described. Based on our results, health and social professionals working to promote healthy ageing across the lifespan will need sound competences regarding person-centred communication, professional communication, technology applications, physiological and pathophysiological aspects of ageing, social and environmental aspects, cultural diversity, programs and policies, ethics, general and basic skills, context and self-management-related skills, health promotion and disease prevention skills, educational and research skills, leadership skills, technological skills and clinical reasoning. Further research should contribute to establishing which competences are more relevant to each discipline and at what level they should be taught, as well as how they can be best implemented to effectively transform health and social care systems., (© 2023. The Author(s).)
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- 2023
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125. Crop Identification Using Deep Learning on LUCAS Crop Cover Photos.
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Yordanov M, d'Andrimont R, Martinez-Sanchez L, Lemoine G, Fasbender D, and van der Velde M
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Massive and high-quality in situ data are essential for Earth-observation-based agricultural monitoring. However, field surveying requires considerable organizational effort and money. Using computer vision to recognize crop types on geo-tagged photos could be a game changer allowing for the provision of timely and accurate crop-specific information. This study presents the first use of the largest multi-year set of labelled close-up in situ photos systematically collected across the European Union from the Land Use Cover Area frame Survey (LUCAS). Benefiting from this unique in situ dataset, this study aims to benchmark and test computer vision models to recognize major crops on close-up photos statistically distributed spatially and through time between 2006 and 2018 in a practical agricultural policy relevant context. The methodology makes use of crop calendars from various sources to ascertain the mature stage of the crop, of an extensive paradigm for the hyper-parameterization of MobileNet from random parameter initialization, and of various techniques from information theory in order to carry out more accurate post-processing filtering on results. The work has produced a dataset of 169,460 images of mature crops for the 12 classes, out of which 15,876 were manually selected as representing a clean sample without any foreign objects or unfavorable conditions. The best-performing model achieved a macro F1 (M-F1) of 0.75 on an imbalanced test dataset of 8642 photos. Using metrics from information theory, namely the equivalence reference probability, resulted in an increase of 6%. The most unfavorable conditions for taking such images, across all crop classes, were found to be too early or late in the season. The proposed methodology shows the possibility of using minimal auxiliary data outside the images themselves in order to achieve an M-F1 of 0.82 for labelling between 12 major European crops.
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- 2023
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126. What moves patients to participate in prehabilitation before major surgery? A mixed methods systematic review.
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van der Velde M, van der Leeden M, Geleijn E, Veenhof C, and Valkenet K
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- Adult, Humans, Qualitative Research, Social Support, Health Personnel, Preoperative Exercise
- Abstract
Background: Prehabilitation offers patients the opportunity to actively participate in their perioperative care by preparing themselves for their upcoming surgery. Experiencing barriers may lead to non-participation, which can result in a reduced functional capacity, delayed post-operative recovery and higher healthcare costs. Insight in the barriers and facilitators to participation in prehabilitation can inform further development and implementation of prehabilitation. The aim of this review was to identify patient-experienced barriers and facilitators for participation in prehabilitation., Methods: For this mixed methods systematic review, articles were searched in PubMed, EMBASE and CINAHL. Articles were eligible for inclusion if they contained data on patient-reported barriers and facilitators to participation in prehabilitation in adults undergoing major surgery. Following database search, and title and abstract screening, full text articles were screened for eligibility and quality was assessed using the Mixed Method Appraisal Tool. Relevant data from the included studies were extracted, coded and categorized into themes, using an inductive approach. Based on these themes, the Capability, Opportunity, Motivation, Behaviour (COM-B) model was chosen to classify the identified themes., Results: Three quantitative, 14 qualitative and 6 mixed methods studies, published between 2007 and 2022, were included in this review. A multitude of factors were identified across the different COM-B components. Barriers included lack of knowledge of the benefits of prehabilitation and not prioritizing prehabilitation over other commitments (psychological capability), physical symptoms and comorbidities (physical capability), lack of time and limited financial capacity (physical opportunity), lack of social support (social opportunity), anxiety and stress (automatic motivation) and previous experiences and feeling too fit for prehabilitation (reflective motivation). Facilitators included knowledge of the benefits of prehabilitation (psychological capability), having access to resources (physical opportunity), social support and encouragement by a health care professional (social support), feeling a sense of control (automatic motivation) and beliefs in own abilities (reflective motivation)., Conclusions: A large number of barriers and facilitators, influencing participation in prehabilitation, were found across all six COM-B components. To reach all patients and to tailor prehabilitation to the patient's needs and preferences, it is important to take into account patients' capability, opportunity and motivation., Trial Registration: Registered in PROSPERO (CRD42021250273) on May 18th, 2021., (© 2023. The Author(s).)
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- 2023
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127. The extreme 2016 wheat yield failure in France.
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Nóia Júnior RS, Deswarte JC, Cohan JP, Martre P, van der Velde M, Lecerf R, Webber H, Ewert F, Ruane AC, Slafer GA, and Asseng S
- Subjects
- France, Soil, Triticum physiology, Edible Grain
- Abstract
France suffered, in 2016, the most extreme wheat yield decline in recent history, with some districts losing 55% yield. To attribute causes, we combined the largest coherent detailed wheat field experimental dataset with statistical and crop model techniques, climate information, and yield physiology. The 2016 yield was composed of up to 40% fewer grains that were up to 30% lighter than expected across eight research stations in France. The flowering stage was affected by prolonged cloud cover and heavy rainfall when 31% of the loss in grain yield was incurred from reduced solar radiation and 19% from floret damage. Grain filling was also affected as 26% of grain yield loss was caused by soil anoxia, 11% by fungal foliar diseases, and 10% by ear blight. Compounding climate effects caused the extreme yield decline. The likelihood of these compound factors recurring under future climate change is estimated to change with a higher frequency of extremely low wheat yields., (© 2023 The Authors. Global Change Biology published by John Wiley & Sons Ltd.)
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- 2023
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128. The effect of garden use on quality of life and behavioral and psychological symptoms of dementia in people living with dementia in nursing homes: a systematic review.
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van der Velde-van Buuringen M, Hendriks-van der Sar R, Verbeek H, Achterberg WP, and Caljouw MAA
- Abstract
Objectives: Considering the importance of going outside in a natural environment for people in general, and people living with dementia in particular, we want to unravel the aspects by which garden use affects quality of life (QoL) and behavioral and psychological symptoms of dementia (BPSD) in people living with dementia in nursing homes., Design: Systematic review., Setting and Participants: People living with dementia in nursing homes., Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eight electronic bibliographic databases were searched (May 2022). Quantitative, qualitative and mixed-methods studies describing the effect of garden use on QoL, BPSD, or other outcomes related to QoL or BPSD in people living with dementia in nursing homes were included. The methodological quality of individual studies was assessed with the Mixed Methods Appraisal Tool (MMAT) and a narrative synthesis of the results was performed., Results: After screening title and abstract ( N = 498), and full-text assessment ( N = 67), 19 publications were included. These described 17 studies and three types of interventions: (1) interventions regarding the evaluation of effects of specifically designed nursing home gardens, (2) participation of the people living with dementia in outside activities, and (3) other interventions, for example, garden visits and different seasons., Conclusions and Implications: Overall, first studies appear to suggest positive effects of garden use on QoL, BPSD, or other outcomes related to QoL or BPSD (stress, sleep, and mood) in people living with dementia in nursing homes. However, consensus regarding measurements and key outcomes, taking into account the physical, social, and organizational aspects when designing the garden use intervention, is necessary for the reliable evaluation of these interventions., Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=283267, identifier: CRD42021283267., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Velde-van Buuringen, Hendriks-van der Sar, Verbeek, Achterberg and Caljouw.)
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- 2023
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129. The development of the Dutch "National model integrated care for childhood overweight and obesity".
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Halberstadt J, Koetsier LW, Sijben M, Stroo J, van der Velde M, van Mil EGAH, and Seidell JC
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- Child, Humans, Overweight therapy, Overweight psychology, Quality of Life, Pediatric Obesity therapy, Pediatric Obesity psychology, Delivery of Health Care, Integrated
- Abstract
Background: Childhood obesity is a chronic disease with negative physical and psychosocial health consequences. To manage childhood overweight and obesity, integrated care as part of an integrated approach is needed. To realise implementation of this integrated care, practical guidance for policy and practice is needed. The aim of this study is to describe the development of a Dutch national model of integrated care for childhood overweight and obesity and accompanying materials for policy and practice., Methods: The development of the national model was led by a university-based team in collaboration with eight selected Dutch municipalities who were responsible for the local realisation of the integrated care and with frequent input from other stakeholders. Learning communities were organised to exchange knowledge, experiences and tools between the participating municipalities., Results: The developed national model describes the vision, process, partners and finance of the integrated care. It sets out a structure that provides a basis for local integrated care that should facilitate support and care for children with overweight or obesity and their families. The accompanying materials are divided into materials for policymakers to support local realisation of the integrated care and materials for healthcare professionals to support them in delivering the needed support and care., Conclusions: The developed national model and accompanying materials can contribute to improvement of support and care for children with overweight or obesity and their families, and thereby help improve the health, quality of life and societal participation of these children. Further implementation of the evidence- and practice-based integrated care while evaluating on the way is needed., (© 2023. The Author(s).)
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- 2023
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130. Scoping literature review and focus groups with healthcare professionals on psychosocial and lifestyle assessments for childhood obesity care.
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Koetsier LW, van den Eynde E, van Mil EGAH, van der Velde M, de Vries R, Baan CA, Seidell JC, and Halberstadt J
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- Humans, Child, Focus Groups, Risk Assessment, Life Style, Delivery of Health Care, Pediatric Obesity
- Abstract
Background: Childhood obesity is a complex disease resulting from the interaction of multiple factors. The effective management of childhood obesity requires assessing the psychosocial and lifestyle factors that may play a role in the development and maintenance of obesity. This study centers on available scientific literature on psychosocial and lifestyle assessments for childhood obesity, and experiences and views of healthcare professionals with regard to assessing psychosocial and lifestyle factors within Dutch integrated care., Methods: Two methods were used. First, a scoping review (in PubMed, Embase, PsycInfo, IBSS, Scopus and Web of Science) was performed by systematically searching for scientific literature on psychosocial and lifestyle assessments for childhood obesity. Data were analysed by extracting data in Microsoft Excel. Second, focus group discussions were held with healthcare professionals from a variety of disciplines and domains to explore their experiences and views about assessing psychosocial and lifestyle factors within Dutch integrated care. Data were analysed using template analysis, complemented with open coding in MAXQDA., Results: The results provide an overview of relevant psychosocial and lifestyle factors that should be assessed and were classified as child, family, parental and lifestyle (e.g. nutrition, physical activity and sleep factors) and structured into psychological and social aspects. Insights into how to assess psychosocial and lifestyle factors were identified as well, including talking about psychosocial factors, lifestyle and weight; the professional-patient relationship; and attitudes of healthcare professionals., Conclusions: This study provides an overview of psychosocial and lifestyle factors that should be identified within the context of childhood obesity care, as they may contribute to the development and maintenance of obesity. The results highlight the importance of both what is assessed and how it is assessed. The results of this study can be used to develop practical tools for facilitating healthcare professionals in conducting a psychosocial and lifestyle assessment., (© 2023. The Author(s).)
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- 2023
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131. Prior Knowledge Norms for Naming Country Outlines: An Open Stimulus Set.
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Wilschut T, van der Velde M, Sense F, and van Rijn H
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Paired-associate stimuli are an important tool in learning and memory research. In cognitive psychology, many studies use materials of which the learners are expected to have little to no prior knowledge. Despite their theoretical usefulness, conclusions from these studies are difficult to generalize to real-world learning contexts, where learners can be expected to have varying degrees of prior knowledge. Here, we present an ecologically valid stimulus set with 112 country outline-name pairs, and report response times and prior knowledge for these items in 285 largely Western European participants. Prior knowledge per item ranged from very high (94.4%) to zero (0.3%), thereby allowing researchers to select materials of which participants can be expected to have any given amount of prior knowledge. As such, this database provides a useful tool for research on real-world learning. The database can be accessed at: https://osf.io/q25rd/., Competing Interests: There are no competing interests to declare., (Copyright: © 2023 The Author(s).)
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- 2023
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132. Gut microbiota of homing pigeons shows summer-winter variation under constant diet indicating a substantial effect of temperature.
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Dietz MW, Matson KD, Versteegh MA, van der Velde M, Parmentier HK, Arts JAJ, Salles JF, and Tieleman BI
- Abstract
Background: Gut microbiotas play a pivotal role in host physiology and behaviour, and may affect host life-history traits such as seasonal variation in host phenotypic state. Generally, seasonal gut microbiota variation is attributed to seasonal diet variation. However, seasonal temperature and day length variation may also drive gut microbiota variation. We investigated summer-winter differences in the gut bacterial community (GBC) in 14 homing pigeons living outdoors under a constant diet by collecting cloacal swabs in both seasons during two years. Because temperature effects may be mediated by host metabolism, we determined basal metabolic rate (BMR) and body mass. Immune competence is influenced by day length and has a close relationship with the GBC, and it may thus be a link between day length and gut microbiota. Therefore, we measured seven innate immune indices. We expected the GBC to show summer-winter differences and to correlate with metabolism and immune indices., Results: BMR, body mass, and two immune indices varied seasonally, other host factors did not. The GBC showed differences between seasons and sexes, and correlated with metabolism and immune indices. The most abundant genus (Lachnoclostridium 12, 12%) and associated higher taxa, were more abundant in winter, though not significantly at the phylum level, Firmicutes. Bacteroidetes were more abundant in summer. The Firmicutes:Bacteroidetes ratio tended to be higher in winter. The KEGG ortholog functions for fatty acid biosynthesis and linoleic acid metabolism (PICRUSt2) had increased abundances in winter., Conclusions: The GBC of homing pigeons varied seasonally, even under a constant diet. The correlations between immune indices and the GBC did not involve consistently specific immune indices and included only one of the two immune indices that showed seasonal differences, suggesting that immune competence may be an unlikely link between day length and the GBC. The correlations between the GBC and metabolism indices, the higher Firmicutes:Bacteroidetes ratio in winter, and the resemblance of the summer-winter differences in the GBC with the general temperature effects on the GBC in the literature, suggest that temperature partly drove the summer-winter differences in the GBC in homing pigeons., (© 2022. The Author(s).)
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- 2022
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133. Telomere heritability and parental age at conception effects in a wild avian population.
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Sparks AM, Spurgin LG, van der Velde M, Fairfield EA, Komdeur J, Burke T, Richardson DS, and Dugdale HL
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- Animals, Female, Humans, Cross-Sectional Studies, Telomere genetics, Parents, Fertilization, Passeriformes genetics
- Abstract
Individual variation in telomere length is predictive of health and mortality risk across a range of species. However, the relative influence of environmental and genetic variation on individual telomere length in wild populations remains poorly understood. Heritability of telomere length has primarily been calculated using parent-offspring regression which can be confounded by shared environments. To control for confounding variables, quantitative genetic "animal models" can be used, but few studies have applied animal models in wild populations. Furthermore, parental age at conception may also influence offspring telomere length, but most studies have been cross-sectional. We investigated within- and between-parental age at conception effects and heritability of telomere length in the Seychelles warbler using measures from birds caught over 20 years and a multigenerational pedigree. We found a weak negative within-paternal age at conception effect (as fathers aged, their offspring had shorter telomeres) and a weak positive between-maternal age at conception effect (females that survived to older ages had offspring with longer telomeres). Animal models provided evidence that heritability and evolvability of telomere length were low in this population, and that variation in telomere length was not driven by early-life effects of hatch period or parental identities. Quantitative polymerase chain reaction plate had a large influence on telomere length variation and not accounting for it in the models would have underestimated heritability. Our study illustrates the need to include and account for technical variation in order to accurately estimate heritability, as well as other environmental effects, on telomere length in natural populations., (© 2021 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.)
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- 2022
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134. Capturing Dynamic Performance in a Cognitive Model: Estimating ACT-R Memory Parameters With the Linear Ballistic Accumulator.
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van der Velde M, Sense F, Borst JP, van Maanen L, and van Rijn H
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- Humans, Models, Theoretical, Cognition physiology
- Abstract
The parameters governing our behavior are in constant flux. Accurately capturing these dynamics in cognitive models poses a challenge to modelers. Here, we demonstrate a mapping of ACT-R's declarative memory onto the linear ballistic accumulator (LBA), a mathematical model describing a competition between evidence accumulation processes. We show that this mapping provides a method for inferring individual ACT-R parameters without requiring the modeler to build and fit an entire ACT-R model. Existing parameter estimation methods for the LBA can be used, instead of the computationally expensive parameter sweeps that are traditionally done. We conduct a parameter recovery study to confirm that the LBA can recover ACT-R parameters from simulated data. Then, as a proof of concept, we use the LBA to estimate ACT-R parameters from an empirical dataset. The resulting parameter estimates provide a cognitively meaningful explanation for observed differences in behavior over time and between individuals. In addition, we find that the mapping between ACT-R and LBA lends a more concrete interpretation to ACT-R's latency factor parameter, namely as a measure of response caution. This work contributes to a growing movement towards integrating formal modeling approaches in cognitive science., (© 2022 The Authors. Topics in Cognitive Science published by Wiley Periodicals LLC on behalf of Cognitive Science Society.)
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- 2022
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135. The microbial environment modulates non-genetic maternal effects on egg immunity.
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van Veelen HPJ, Salles JF, Matson KD, van Doorn GS, van der Velde M, and Tieleman BI
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Background: In a diverse microbial world immune function of animals is essential. Diverse microbial environments may contribute to extensive variation in immunological phenotypes of vertebrates, among and within species and individuals. As maternal effects benefit offspring development and survival, whether females use cues about their microbial environment to prime offspring immune function is unclear. To provide microbial environmental context to maternal effects, we asked if the bacterial diversity of the living environment of female zebra finches Taeniopygia guttata shapes maternal effects on egg immune function. We manipulated environmental bacterial diversity of birds and tested if females increased immunological investment in eggs in an environment with high bacterial diversity (untreated soil) versus low (gamma-sterilized soil). We quantified lysozyme and ovotransferrin in egg albumen and IgY in egg yolk and in female blood, and we used 16S rRNA gene sequencing to profile maternal cloacal and eggshell microbiotas., Results: We found a maternal effect on egg IgY concentration that reflected environmental microbial diversity: females who experienced high diversity deposited more IgY in their eggs, but only if maternal plasma IgY levels were relatively high. We found no effects on lysozyme and ovotransferrin concentrations in albumen. Moreover, we uncovered that variation in egg immune traits could be significantly attributed to differences among females: for IgY concentration in yolk repeatability R = 0.80; for lysozyme concentration in albumen R = 0.27. Furthermore, a partial least squares path model (PLS-PM) linking immune parameters of females and eggs, which included maternal and eggshell microbiota structures and female body condition, recapitulated the treatment-dependent yolk IgY response. The PLS-PM additionally suggested that the microbiota and physical condition of females contributed to shaping maternal effects on egg immune function, and that (non-specific) innate egg immunity was prioritized in the environment with low bacterial diversity., Conclusions: The microbial environment of birds can shape maternal effects on egg immune function. Since immunological priming of eggs benefits offspring, we highlight that non-genetic maternal effects on yolk IgY levels based on cues from the parental microbial environment may prove important for offspring to thrive in the microbial environment that they are expected to face., (© 2022. The Author(s).)
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- 2022
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136. Benefits of Adaptive Learning Transfer From Typing-Based Learning to Speech-Based Learning.
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Wilschut T, Sense F, van der Velde M, Fountas Z, Maaß SC, and van Rijn H
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Memorising vocabulary is an important aspect of formal foreign-language learning. Advances in cognitive psychology have led to the development of adaptive learning systems that make vocabulary learning more efficient. One way these computer-based systems optimize learning is by measuring learning performance in real time to create optimal repetition schedules for individual learners. While such adaptive learning systems have been successfully applied to word learning using keyboard-based input, they have thus far seen little application in word learning where spoken instead of typed input is used. Here we present a framework for speech-based word learning using an adaptive model that was developed for and tested with typing-based word learning. We show that typing- and speech-based learning result in similar behavioral patterns that can be used to reliably estimate individual memory processes. We extend earlier findings demonstrating that a response-time based adaptive learning approach outperforms an accuracy-based, Leitner flashcard approach in learning efficiency (demonstrated by higher average accuracy and lower response times after a learning session). In short, we show that adaptive learning benefits transfer from typing-based learning, to speech based learning. Our work provides a basis for the development of language learning applications that use real-time pronunciation assessment software to score the accuracy of the learner's pronunciations. We discuss the implications for our approach for the development of educationally relevant, adaptive speech-based learning applications., Competing Interests: Author ZF was employed by Emotech Ltd. An earlier version of the adaptive learning system discussed in this manuscript is licensed to SlimStampen B.V., a University of Groningen supported spin-off directed by HvR. No commercial or financial interests have influenced the setup, analysis, or reporting of this study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Wilschut, Sense, van der Velde, Fountas, Maaß and van Rijn.)
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- 2021
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137. Height Versus Body Surface Area to Normalize Cardiovascular Measurements in Children Using the Pediatric Heart Network Echocardiographic Z-Score Database.
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Mahgerefteh J, Lai W, Colan S, Trachtenberg F, Gongwer R, Stylianou M, Bhat AH, Goldberg D, McCrindle B, Frommelt P, Sachdeva R, Shuplock JM, Spurney C, Troung D, Cnota JF, Camarda JA, Levine J, Pignatelli R, Altmann K, van der Velde M, Thankavel PP, Chowdhury S, Srivastava S, Johnson TR, and Lopez L
- Subjects
- Adolescent, Cardiovascular Diseases diagnostic imaging, Child, Child, Preschool, Databases, Factual, Echocardiography, Female, Heart diagnostic imaging, Humans, Male, Pediatric Obesity epidemiology, Pediatrics, Reference Values, Body Height, Body Surface Area, Cardiovascular Diseases diagnosis, Heart anatomy & histology
- Abstract
Normalizing cardiovascular measurements for body size allows for comparison among children of different ages and for distinguishing pathologic changes from normal physiologic growth. Because of growing interest to use height for normalization, the aim of this study was to develop height-based normalization models and compare them to body surface area (BSA)-based normalization for aortic and left ventricular (LV) measurements. The study population consisted of healthy, non-obese children between 2 and 18 years of age enrolled in the Pediatric Heart Network Echo Z-Score Project. The echocardiographic study parameters included proximal aortic diameters at 3 locations, LV end-diastolic volume, and LV mass. Using the statistical methodology described in the original project, Z-scores based on height and BSA were determined for the study parameters and tested for any clinically significant relationships with age, sex, race, ethnicity, and body mass index (BMI). Normalization models based on height versus BSA were compared among underweight, normal weight, and overweight (but not obese) children in the study population. Z-scores based on height and BSA were calculated for the 5 study parameters and revealed no clinically significant relationships with age, sex, race, and ethnicity. Normalization based on height resulted in lower Z-scores in the underweight group compared to the overweight group, whereas normalization based on BSA resulted in higher Z-scores in the underweight group compared to the overweight group. In other words, increasing BMI had an opposite effect on height-based Z-scores compared to BSA-based Z-scores. Allometric normalization based on height and BSA for aortic and LV sizes is feasible. However, height-based normalization results in higher cardiovascular Z-scores in heavier children, and BSA-based normalization results in higher cardiovascular Z-scores in lighter children. Further studies are needed to assess the performance of these approaches in obese children with or without cardiac disease., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2021
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138. Daily garden use and quality of life in persons with advanced dementia living in a nursing home: A feasibility study.
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van der Velde-van Buuringen M, Achterberg WP, and Caljouw MAA
- Subjects
- Feasibility Studies, Gardens, Humans, Nursing Homes, Dementia, Quality of Life
- Abstract
Aim: To evaluate the process of daily going outside in a nursing home garden and explore the effect of garden use on quality of life and neuropsychiatric symptoms in persons with dementia., Design: A feasibility study with quantitative and qualitative approaches., Methods: Twenty residents with a diagnosis of moderate-to-severe dementia participated. The intervention consisted of at least 30 min of garden use, whereby any activity outside is possible as long as it is person-centred and fitting within usual daily nursing home practice. Interviews were held with caregivers, and questionnaires were sent to other disciplines involved. Quality of life (QUALIDEM) and neuropsychiatric symptoms (NPI-NH) were collected at baseline, intervention and postintervention., Results: Caregivers experienced and observed benefits of going outside for themselves, in residents and relatives. Incorporating daily garden use does not imply an additional task, but rather rearranging priorities and doing the usual activities outside a part of the time., (© 2020 The Authors. Nursing Open published by John Wiley & Sons Ltd.)
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- 2021
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139. A European Research Agenda for Geriatric Emergency Medicine: a modified Delphi study.
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Mooijaart SP, Nickel CH, Conroy SP, Lucke JA, van Tol LS, Olthof M, Blomaard LC, Buurman BM, Dundar ZD, de Groot B, Gasperini B, Heeren P, Karamercan MA, McNamara R, Mitchell A, van Oppen JD, Martin Sanchez FJ, Schoon Y, Singler K, Spode R, Skúldóttir S, Thorrsteindottir T, van der Velde M, and Wallace J
- Subjects
- Aged, Delphi Technique, Emergency Service, Hospital, Europe, Humans, Emergency Medicine, Health Priorities
- Abstract
Purpose: Geriatric Emergency Medicine (GEM) focuses on delivering optimal care to (sub)acutely ill older people. This involves a multidisciplinary approach throughout the whole healthcare chain. However, the underpinning evidence base is weak and it is unclear which research questions have the highest priority. The aim of this study was to provide an inventory and prioritisation of research questions among GEM professionals throughout Europe., Methods: A two-stage modified Delphi approach was used. In stage 1, an online survey was administered to various professionals working in GEM both in the Emergency Department (ED) and other healthcare settings throughout Europe to make an inventory of potential research questions. In the processing phase, research questions were screened, categorised, and validated by an expert panel. Subsequently, in stage 2, remaining research questions were ranked based on relevance using a second online survey administered to the same target population, to identify the top 10 prioritised research questions., Results: In response to the first survey, 145 respondents submitted 233 potential research questions. A total of 61 research questions were included in the second stage, which was completed by 176 respondents. The question with the highest priority was: Is implementation of elements of CGA (comprehensive geriatric assessment), such as screening for frailty and geriatric interventions, effective in improving outcomes for older patients in the ED?, Conclusion: This study presents a top 10 of high-priority research questions for a European Research Agenda for Geriatric Emergency Medicine. The list of research questions may serve as guidance for researchers, policymakers and funding bodies in prioritising future research projects.
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- 2021
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140. Usability and Preliminary Effectiveness of a Preoperative mHealth App for People Undergoing Major Surgery: Pilot Randomized Controlled Trial.
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van der Velde M, Valkenet K, Geleijn E, Kruisselbrink M, Marsman M, Janssen LM, Ruurda JP, van der Peet DL, Aarden JJ, Veenhof C, and van der Leeden M
- Subjects
- Aged, Female, Humans, Middle Aged, Netherlands, Patient Reported Outcome Measures, Pilot Projects, Preoperative Care, Preoperative Period, Mobile Applications, Muscle Stretching Exercises, Preoperative Exercise, Telemedicine
- Abstract
Background: Major surgery is associated with negative postoperative outcomes such as complications and delayed or poor recovery. Multimodal prehabilitation can help to reduce the negative effects of major surgery. Offering prehabilitation by means of mobile health (mHealth) could be an effective new approach., Objective: The objectives of this pilot study were to (1) evaluate the usability of the Be Prepared mHealth app prototype for people undergoing major surgery, (2) explore whether the app was capable of bringing about a change in risk behaviors, and (3) estimate a preliminary effect of the app on functional recovery after major surgery., Methods: A mixed-methods pilot randomized controlled trial was conducted in two Dutch academic hospitals. In total, 86 people undergoing major surgery participated. Participants in the intervention group received access to the Be Prepared app, a smartphone app using behavior change techniques to address risk behavior prior to surgery. Both groups received care as usual. Usability (System Usability Scale), change in risk behaviors 3 days prior to surgery, and functional recovery 30 days after discharge from hospital (Patient-Reported Outcomes Measurement Information System physical functioning 8-item short form) were assessed using online questionnaires. Quantitative data were analyzed using descriptive statistics, chi-square tests, and multivariable linear regression. Semistructured interviews about the usability of the app were conducted with 12 participants in the intervention group. Thematic analysis was used to analyze qualitative data., Results: Seventy-nine people-40 in the intervention group and 39 in the control group-were available for further analysis. Participants had a median age of 61 (interquartile range 51.0-68.0) years. The System Usability Scale showed that patients considered the Be Prepared app to have acceptable usability (mean 68.2 [SD 18.4]). Interviews supported the usability of the app. The major point of improvement identified was further personalization of the app. Compared with the control group, the intervention group showed an increase in self-reported physical activity and muscle strengthening activities prior to surgery. Also, 2 of 2 frequent alcohol users in the intervention group versus 1 of 9 in the control group drank less alcohol in the run-up to surgery. No difference was found in change of smoking cessation. Between-group analysis showed no meaningful differences in functional recovery after correction for baseline values (β=-2.4 [95% CI -5.9 to 1.1])., Conclusions: The Be Prepared app prototype shows potential in terms of usability and changing risk behavior prior to major surgery. No preliminary effect of the app on functional recovery was found. Points of improvement have been identified with which the app and future research can be optimized., Trial Registration: Netherlands Trial Registry NL8623; https://www.trialregister.nl/trial/8623., (©Miriam van der Velde, Karin Valkenet, Edwin Geleijn, Marjoke Kruisselbrink, Marije Marsman, Liedewij MJ Janssen, Jelle P Ruurda, Donald L van der Peet, Jesse J Aarden, Cindy Veenhof, Marike van der Leeden. Originally published in JMIR mHealth and uHealth (http://mhealth.jmir.org), 07.01.2021.)
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- 2021
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141. Evaluating quality in acute care using patient reported outcome measures: a scoping review.
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Mols EM, van der Velde M, Nanayakkara P, Haak HR, and Kremers M
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- Critical Care, Humans, Psychometrics, Surveys and Questionnaires, Checklist, Patient Reported Outcome Measures
- Abstract
The aim of this scoping review is to identify patient reported outcome measures (PROMs) in acute care settings, assess their psychometric properties and provide recommendations for their use in daily practice. We performed a search in the PubMed database to identify publications concerning PROMs in an acute care setting. The COSMIN checklist was used to assess the psychometric properties of the reported PROMs. We found 1407 publications and included 14 articles, describing 15 measures. Most publications provided limited information on psychometric properties. Three generic PROMs were deemed of adequate quality for use in acute care. We recommend future development and evaluation of PROMs focussing on acute care to further evaluate and improve the quality of acute care.
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- 2021
142. Verifiable soil organic carbon modelling to facilitate regional reporting of cropland carbon change: A test case in the Czech Republic.
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Balkovič J, Madaras M, Skalský R, Folberth C, Smatanová M, Schmid E, van der Velde M, Kraxner F, and Obersteiner M
- Subjects
- Agriculture, Crops, Agricultural, Czech Republic, Europe, Carbon analysis, Soil
- Abstract
Regional monitoring, reporting and verification of soil organic carbon change occurring in managed cropland are indispensable to support carbon-related policies. Rapidly evolving gridded agronomic models can facilitate these efforts throughout Europe. However, their performance in modelling soil carbon dynamics at regional scale is yet unexplored. Importantly, as such models are often driven by large-scale inputs, they need to be benchmarked against field experiments. We elucidate the level of detail that needs to be incorporated in gridded models to robustly estimate regional soil carbon dynamics in managed cropland, testing the approach for regions in the Czech Republic. We first calibrated the biogeochemical Environmental Policy Integrated Climate (EPIC) model against long-term experiments. Subsequently, we examined the EPIC model within a top-down gridded modelling framework constructed for European agricultural soils from Europe-wide datasets and regional land-use statistics. We explored the top-down, as opposed to a bottom-up, modelling approach for reporting agronomically relevant and verifiable soil carbon dynamics. In comparison with a no-input baseline, the regional EPIC model suggested soil carbon changes (~0.1-0.5 Mg C ha
-1 y-1 ) consistent with empirical-based studies for all studied agricultural practices. However, inaccurate soil information, crop management inputs, or inappropriate model calibration may undermine regional modelling of cropland management effect on carbon since each of the three components carry uncertainty (~0.5-1.5 Mg C ha-1 y-1 ) that is substantially larger than the actual effect of agricultural practices relative to the no-input baseline. Besides, inaccurate soil data obtained from the background datasets biased the simulated carbon trends compared to observations, thus hampering the model's verifiability at the locations of field experiments. Encouragingly, the top-down agricultural management derived from regional land-use statistics proved suitable for the estimation of soil carbon dynamics consistently with actual field practices. Despite sensitivity to biophysical parameters, we found a robust scalability of the soil organic carbon routine for various climatic regions and soil types represented in the Czech experiments. The model performed better than the tier 1 methodology of the Intergovernmental Panel on Climate Change, which indicates a great potential for improved carbon change modelling over larger political regions., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2020
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143. Harmonised LUCAS in-situ land cover and use database for field surveys from 2006 to 2018 in the European Union.
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d'Andrimont R, Yordanov M, Martinez-Sanchez L, Eiselt B, Palmieri A, Dominici P, Gallego J, Reuter HI, Joebges C, Lemoine G, and van der Velde M
- Abstract
Accurately characterizing land surface changes with Earth Observation requires geo-located ground truth. In the European Union (EU), a tri-annual surveyed sample of land cover and land use has been collected since 2006 under the Land Use/Cover Area frame Survey (LUCAS). A total of 1351293 observations at 651780 unique locations for 106 variables along with 5.4 million photos were collected during five LUCAS surveys. Until now, these data have never been harmonised into one database, limiting full exploitation of the information. This paper describes the LUCAS point sampling/surveying methodology, including collection of standard variables such as land cover, environmental parameters, and full resolution landscape and point photos, and then describes the harmonisation process. The resulting harmonised database is the most comprehensive in-situ dataset on land cover and use in the EU. The database is valuable for geo-spatial and statistical analysis of land use and land cover change. Furthermore, its potential to provide multi-temporal in-situ data will be enhanced by recent computational advances such as deep learning.
- Published
- 2020
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144. Microbial environment shapes immune function and cloacal microbiota dynamics in zebra finches Taeniopygia guttata.
- Author
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van Veelen HPJ, Falcão Salles J, Matson KD, van der Velde M, and Tieleman BI
- Abstract
Background: The relevance of the host microbiota to host ecology and evolution is well acknowledged. However, the effect of the microbial environment on host immune function and host microbiota dynamics is understudied in terrestrial vertebrates. Using a novel experimental approach centered on the manipulation of the microbial environment of zebra finches Taeniopygia guttata, we carried out a study to investigate effects of the host's microbial environment on: 1) constitutive immune function, 2) the resilience of the host cloacal microbiota; and 3) the degree to which immune function and host microbiota covary in microbial environments that differ in diversity., Results: We explored immune indices (hemagglutination, hemolysis, IgY levels and haptoglobin concentration) and host-associated microbiota (diversity and composition) in birds exposed to two experimental microbial environments differing in microbial diversity. According to our expectations, exposure to experimental microbial environments led to differences related to specific antibodies: IgY levels were elevated in the high diversity treatment, whereas we found no effects for the other immune indices. Furthermore, according to predictions, we found significantly increased richness of dominant OTUs for cloacal microbiota of birds of the high diversity compared with the low diversity group. In addition, cloacal microbiota of individual females approached their baseline state sooner in the low diversity environment than females in the high diversity environment. This result supported a direct phenotypically plastic response of host microbiota, and suggests that its resilience depends on environmental microbial diversity. Finally, immune indices and cloacal microbiota composition tend to covary within treatment groups, while at the same time, individuals exhibited consistent differences of immune indices and microbiota characteristics., Conclusion: We show that microbes in the surroundings of terrestrial vertebrates can influence immune function and host-associated microbiota dynamics over relatively short time scales. We suggest that covariation between immune indices and cloacal microbiota, in addition to large and consistent differences among individuals, provides potential for evolutionary adaptation. Ultimately, our study highlights that linking environmental and host microbiotas may help unravelling immunological variation within and potentially among species, and together these efforts will advance the integration of microbial ecology and ecological immunology.
- Published
- 2020
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145. Detecting flowering phenology in oil seed rape parcels with Sentinel-1 and -2 time series.
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d'Andrimont R, Taymans M, Lemoine G, Ceglar A, Yordanov M, and van der Velde M
- Abstract
A novel methodology is proposed to robustly map oil seed rape (OSR) flowering phenology from time series generated from the Copernicus Sentinel-1 (S1) and Sentinel-2 (S2) sensors. The time series are averaged at parcel level, initially for a set of 229 reference parcels for which multiple phenological observations on OSR flowering have been collected from April 21 to May 19, 2018. The set of OSR parcels is extended to a regional sample of 32,355 OSR parcels derived from a regional S2 classification. The study area comprises the northern Brandenburg and Mecklenburg-Vorpommern (N) and the southern Bavaria (S) regions in Germany. A method was developed to automatically compute peak flowering at parcel level from the S2 time signature of the Normalized Difference Yellow Index (NDYI) and from the local minimum in S1 VV polarized backscattering coefficients. Peak flowering was determined at a temporal accuracy of 1 to 4 days. A systematic flowering delay of 1 day was observed in the S1 detection compared to S2. Peak flowering differed by 12 days between the N and S. Considerable local variation was observed in the N-S parcel-level flowering gradient. Additional in-situ phenology observations at 70 Deutscher Wetterdienst (DWD) stations confirm the spatial and temporal consistency between S1 and S2 signatures and flowering phenology across both regions. Conditions during flowering strongly determine OSR yield, therefore, the capacity to continuously characterize spatially the timing of key flowering dates across large areas is key. To illustrate this, expected flowering dates were simulated assuming a single OSR variety with a 425 growing degree days (GDD) requirement to reach flowering. This GDD requirement was calculated based on parcel-level peak flowering dates and temperatures accumulated from 25-km gridded meteorological data. The correlation between simulated and S2 observed peak flowering dates still equaled 0.84 and 0.54 for the N and S respectively. These Sentinel-based parcel-level flowering parameters can be combined with weather data to support in-season predictions of OSR yield, area, and production. Our approach identified the unique temporal signatures of S1 and S2 associated with OSR flowering and can now be applied to monitor OSR phenology for parcels across the globe., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2020 The Authors.)
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- 2020
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146. Prenatal Transfer of Gut Bacteria in Rock Pigeon.
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Dietz MW, Salles JF, Hsu BY, Dijkstra C, Groothuis TGG, van der Velde M, Verkuil YI, and Tieleman BI
- Abstract
Vertebrates evolved in concert with bacteria and have developed essential mutualistic relationships. Gut bacteria are vital for the postnatal development of most organs and the immune and metabolic systems and may likewise play a role during prenatal development. Prenatal transfer of gut bacteria is shown in four mammalian species, including humans. For the 92% of the vertebrates that are oviparous, prenatal transfer is debated, but it has been demonstrated in domestic chicken. We hypothesize that also non-domestic birds can prenatally transmit gut bacteria. We investigated this in medium-sized Rock pigeon ( Columba livia ), ensuring neonates producing fair-sized first faeces. The first faeces of 21 neonate rock pigeons hatched in an incubator, contained a microbiome (bacterial community) the composition of which resembled the cloacal microbiome of females sampled from the same population ( N = 5) as indicated by multiple shared phyla, orders, families, and genera. Neonates and females shared 16.1% of the total number of OTUs present (2881), and neonates shared 45.5% of their core microbiome with females. In contrast, the five females shared only 0.3% of the 1030 female OTUs present. These findings suggest that prenatal gut bacterial transfer may occur in birds. Our results support the hypothesis that gut bacteria may be important for prenatal development and present a heritability pathway of gut bacteria in vertebrates.
- Published
- 2019
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147. Environmental footprint family to address local to planetary sustainability and deliver on the SDGs.
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Vanham D, Leip A, Galli A, Kastner T, Bruckner M, Uwizeye A, van Dijk K, Ercin E, Dalin C, Brandão M, Bastianoni S, Fang K, Leach A, Chapagain A, Van der Velde M, Sala S, Pant R, Mancini L, Monforti-Ferrario F, Carmona-Garcia G, Marques A, Weiss F, and Hoekstra AY
- Abstract
The number of publications on environmental footprint indicators has been growing rapidly, but with limited efforts to integrate different footprints into a coherent framework. Such integration is important for comprehensive understanding of environmental issues, policy formulation and assessment of trade-offs between different environmental concerns. Here, we systematize published footprint studies and define a family of footprints that can be used for the assessment of environmental sustainability. We identify overlaps between different footprints and analyse how they relate to the nine planetary boundaries and visualize the crucial information they provide for local and planetary sustainability. In addition, we assess how the footprint family delivers on measuring progress towards Sustainable Development Goals (SDGs), considering its ability to quantify environmental pressures along the supply chain and relating them to the water-energy-food-ecosystem (WEFE) nexus and ecosystem services. We argue that the footprint family is a flexible framework where particular members can be included or excluded according to the context or area of concern. Our paper is based upon a recent workshop bringing together global leading experts on existing environmental footprint indicators., (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
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148. Global relative species loss due to first-generation biofuel production for the transport sector.
- Author
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Elshout PMF, van Zelm R, van der Velde M, Steinmann Z, and Huijbregts MAJ
- Abstract
The global demand for biofuels in the transport sector may lead to significant biodiversity impacts via multiple human pressures. Biodiversity assessments of biofuels, however, seldom simultaneously address several impact pathways, which can lead to biased comparisons with fossil fuels. The goal of the present study was to quantify the direct influence of habitat loss, water consumption and greenhouse gas (GHG) emissions on potential global species richness loss due to the current production of first-generation biodiesel from soybean and rapeseed and bioethanol from sugarcane and corn. We found that the global relative species loss due to biofuel production exceeded that of fossil petrol and diesel production in more than 90% of the locations considered. Habitat loss was the dominating stressor with Chinese corn, Brazilian soybean and Brazilian sugarcane having a particularly large biodiversity impact. Spatial variation within countries was high, with 90th percentiles differing by a factor of 9 to 22 between locations. We conclude that displacing fossil fuels with first-generation biofuels will likely negatively affect global biodiversity, no matter which feedstock is used or where it is produced. Environmental policy may therefore focus on the introduction of other renewable options in the transport sector.
- Published
- 2019
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149. Global wheat production with 1.5 and 2.0°C above pre-industrial warming.
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Liu B, Martre P, Ewert F, Porter JR, Challinor AJ, Müller C, Ruane AC, Waha K, Thorburn PJ, Aggarwal PK, Ahmed M, Balkovič J, Basso B, Biernath C, Bindi M, Cammarano D, De Sanctis G, Dumont B, Espadafor M, Eyshi Rezaei E, Ferrise R, Garcia-Vila M, Gayler S, Gao Y, Horan H, Hoogenboom G, Izaurralde RC, Jones CD, Kassie BT, Kersebaum KC, Klein C, Koehler AK, Maiorano A, Minoli S, Montesino San Martin M, Naresh Kumar S, Nendel C, O'Leary GJ, Palosuo T, Priesack E, Ripoche D, Rötter RP, Semenov MA, Stöckle C, Streck T, Supit I, Tao F, Van der Velde M, Wallach D, Wang E, Webber H, Wolf J, Xiao L, Zhang Z, Zhao Z, Zhu Y, and Asseng S
- Abstract
Efforts to limit global warming to below 2°C in relation to the pre-industrial level are under way, in accordance with the 2015 Paris Agreement. However, most impact research on agriculture to date has focused on impacts of warming >2°C on mean crop yields, and many previous studies did not focus sufficiently on extreme events and yield interannual variability. Here, with the latest climate scenarios from the Half a degree Additional warming, Prognosis and Projected Impacts (HAPPI) project, we evaluated the impacts of the 2015 Paris Agreement range of global warming (1.5 and 2.0°C warming above the pre-industrial period) on global wheat production and local yield variability. A multi-crop and multi-climate model ensemble over a global network of sites developed by the Agricultural Model Intercomparison and Improvement Project (AgMIP) for Wheat was used to represent major rainfed and irrigated wheat cropping systems. Results show that projected global wheat production will change by -2.3% to 7.0% under the 1.5°C scenario and -2.4% to 10.5% under the 2.0°C scenario, compared to a baseline of 1980-2010, when considering changes in local temperature, rainfall, and global atmospheric CO
2 concentration, but no changes in management or wheat cultivars. The projected impact on wheat production varies spatially; a larger increase is projected for temperate high rainfall regions than for moderate hot low rainfall and irrigated regions. Grain yields in warmer regions are more likely to be reduced than in cooler regions. Despite mostly positive impacts on global average grain yields, the frequency of extremely low yields (bottom 5 percentile of baseline distribution) and yield inter-annual variability will increase under both warming scenarios for some of the hot growing locations, including locations from the second largest global wheat producer-India, which supplies more than 14% of global wheat. The projected global impact of warming <2°C on wheat production is therefore not evenly distributed and will affect regional food security across the globe as well as food prices and trade., (© 2018 John Wiley & Sons Ltd.)- Published
- 2019
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150. Climate change impact and adaptation for wheat protein.
- Author
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Asseng S, Martre P, Maiorano A, Rötter RP, O'Leary GJ, Fitzgerald GJ, Girousse C, Motzo R, Giunta F, Babar MA, Reynolds MP, Kheir AMS, Thorburn PJ, Waha K, Ruane AC, Aggarwal PK, Ahmed M, Balkovič J, Basso B, Biernath C, Bindi M, Cammarano D, Challinor AJ, De Sanctis G, Dumont B, Eyshi Rezaei E, Fereres E, Ferrise R, Garcia-Vila M, Gayler S, Gao Y, Horan H, Hoogenboom G, Izaurralde RC, Jabloun M, Jones CD, Kassie BT, Kersebaum KC, Klein C, Koehler AK, Liu B, Minoli S, Montesino San Martin M, Müller C, Naresh Kumar S, Nendel C, Olesen JE, Palosuo T, Porter JR, Priesack E, Ripoche D, Semenov MA, Stöckle C, Stratonovitch P, Streck T, Supit I, Tao F, Van der Velde M, Wallach D, Wang E, Webber H, Wolf J, Xiao L, Zhang Z, Zhao Z, Zhu Y, and Ewert F
- Subjects
- Carbon Dioxide metabolism, Droughts, Food Quality, Models, Theoretical, Nitrogen metabolism, Temperature, Adaptation, Physiological, Climate Change, Grain Proteins analysis, Triticum chemistry, Triticum physiology
- Abstract
Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32-multi-model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO
2 concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Grain and protein yields are expected to be lower and more variable in most low-rainfall regions, with nitrogen availability limiting growth stimulus from elevated CO2 . Introducing genotypes adapted to warmer temperatures (and also considering changes in CO2 and rainfall) could boost global wheat yield by 7% and protein yield by 2%, but grain protein concentration would be reduced by -1.1 percentage points, representing a relative change of -8.6%. Climate change adaptations that benefit grain yield are not always positive for grain quality, putting additional pressure on global wheat production., (© 2018 John Wiley & Sons Ltd.)- Published
- 2019
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