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1,235 results on '"Lupo, Philip J"'

101. Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children’s Oncology Group

Author

Martin-Giacalone, Bailey A, primary, Richard, Melissa A, additional, Scheurer, Michael E, additional, Khan, Javed, additional, Sok, Pagna, additional, Shetty, Priya B, additional, Chanock, Stephen J, additional, Li, Shengchao Alfred, additional, Yeager, Meredith, additional, Marquez-Do, Deborah A, additional, Barkauskas, Donald A, additional, Hall, David, additional, McEvoy, Matthew T, additional, Brown, Austin L, additional, Sabo, Aniko, additional, Scheet, Paul, additional, Huff, Chad D, additional, Skapek, Stephen X, additional, Hawkins, Douglas S, additional, Venkatramani, Rajkumar, additional, Mirabello, Lisa, additional, and Lupo, Philip J, additional

Published
2023
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102. Prevalence and descriptive epidemiology of Turner syndrome in the United States, 2000–2017: A report from the National Birth Defects Prevention Network

Author

Martin‐Giacalone, Bailey A., primary, Lin, Angela E., additional, Rasmussen, Sonja A., additional, Kirby, Russell S., additional, Nestoridi, Eirini, additional, Liberman, Rebecca F., additional, Agopian, A. J., additional, Carey, John C., additional, Cragan, Janet D., additional, Forestieri, Nina, additional, Leedom, Vinita, additional, Boyce, Aubree, additional, Nembhard, Wendy N., additional, Piccardi, Monika, additional, Sandidge, Theresa, additional, Shan, Xiaoyi, additional, Shumate, Charles J., additional, Stallings, Erin B., additional, Stevenson, Roger, additional, and Lupo, Philip J., additional

Published
2023
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104. Patterns of co-occurring birth defects among infants with hypospadias

Author

Ludorf, Katherine L., Benjamin, Renata H., Navarro Sanchez, Maria Luisa, McLean, Scott D., Northrup, Hope, Mitchell, Laura E., Langlois, Peter H., Canfield, Mark A., Scheuerle, Angela E., Scott, Daryl A., Schaaf, Christian P., Ray, Joseph W., Oluwafemi, Omobola, Chen, Han, Swartz, Michael D., Lupo, Philip J., and Agopian, A.J.

Published
2021
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106. Associations between birth defects with neural crest cell origins and pediatric embryonal tumors.

Author

Wong, Eugene C., Lupo, Philip J., Desrosiers, Tania A., Nichols, Hazel B., Smith, Susan M., Poole, Charles, Canfield, Mark, Shumate, Charles, Chambers, Tiffany M., Schraw, Jeremy M., Nembhard, Wendy N., Yazdy, Mahsa M., Nestoridi, Eirini, Janitz, Amanda E., and Olshan, Andrew F.

Subjects
*NEURAL crest, *HUMAN abnormalities, *TUMORS in children, *CONGENITAL heart disease, *HIRSCHSPRUNG'S disease
Abstract

Background: There are few assessments evaluating associations between birth defects with neural crest cell developmental origins (BDNCOs) and embryonal tumors, which are characterized by undifferentiated cells having a molecular profile similar to neural crest cells. The effect of BDNCOs on embryonal tumors was estimated to explore potential shared etiologic pathways and genetic origins. Methods: With the use of a multistate, registry‐linkage cohort study, BDNCO–embryonal tumor associations were evaluated by generating hazard ratios (HRs) and 95% confidence intervals (CIs) with Cox regression models. BDNCOs consisted of ear, face, and neck defects, Hirschsprung disease, and a selection of congenital heart defects. Embryonal tumors included neuroblastoma, nephroblastoma, and hepatoblastoma. Potential HR modification (HRM) was investigated by infant sex, maternal race/ethnicity, maternal age, and maternal education. Results: The risk of embryonal tumors among those with BDNCOs was 0.09% (co‐occurring n = 105) compared to 0.03% (95% CI, 0.03%–0.04%) among those without a birth defect. Children with BDNCOs were 4.2 times (95% CI, 3.5–5.1 times) as likely to be diagnosed with an embryonal tumor compared to children born without a birth defect. BDNCOs were strongly associated with hepatoblastoma (HR, 16.1; 95% CI, 11.3–22.9), and the HRs for neuroblastoma (3.1; 95% CI, 2.3–4.2) and nephroblastoma (2.9; 95% CI, 1.9–4.4) were elevated. There was no notable HRM by the aforementioned factors. Conclusions: Children with BDNCOs are more likely to develop embryonal tumors compared to children without a birth defect. Disruptions of shared developmental pathways may contribute to both phenotypes, which could inform future genomic assessments and cancer surveillance strategies of these conditions. Associations between nonchromosomal birth defects of neural crest cell developmental origins and pediatric embryonal tumors were investigated based on potential shared developmental pathways. With the use of data from a multistate, registry‐linkage cohort study, children born with these birth defects were found to be more likely (hazard ratio, 4.2; 95% CI, 3.5–5.1) to be diagnosed with the selected embryonal tumors than children without a birth defect, especially hepatoblastoma (hazard ratio, 16.1; 95% CI, 11.3–22.9). [ABSTRACT FROM AUTHOR]

Published
2023
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107. Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.

Author

Schraw, Jeremy M., Sok, Pagna, Desrosiers, Tania A., Janitz, Amanda E., Langlois, Peter H., Canfield, Mark A., Frazier, A. Lindsay, Plon, Sharon E., Lupo, Philip J., and Poynter, Jenny N.

Subjects
GERM cell tumors, CONGENITAL disorders, HUMAN abnormalities, KLINEFELTER'S syndrome, CONGENITAL heart disease, DOWN syndrome
Abstract

Background: Studies have reported increased rates of birth defects among children with germ cell tumors (GCTs). However, few studies have evaluated associations by sex, type of defect, or tumor characteristics. Methods: Birth defect–GCT associations were evaluated among pediatric patients (N = 552) with GCTs enrolled in the Germ Cell Tumor Epidemiology Study and population‐based controls (N = 6380) without cancer from the Genetic Overlap Between Anomalies and Cancer in Kids Study. The odds ratio (OR) and 95% confidence interval (CI) of GCTs according to birth defects status were estimated by using unconditional logistic regression. All defects were considered collectively and by genetic and chromosomal syndromes and nonsyndromic defects. Stratification was by sex, tumor histology (yolk sac tumor, teratoma, germinoma, and mixed/other), and location (gonadal, extragonadal, and intracranial). Results: Birth defects and syndromic defects were more common among GCT cases than controls (6.9% vs. 4.0% and 2.7% vs. 0.2%, respectively; both p <.001). In multivariable models, GCT risk was increased among children with birth defects (OR, 1.7; 95% CI, 1.3–2.4) and syndromic defects (OR, 10.4; 95% CI, 4.9–22.1). When stratified by tumor characteristics, birth defects were associated with yolk sac tumors (OR, 2.7; 95% CI, 1.3–5.0) and mixed/other histologies (OR, 2.1; 95% CI, 1.2–3.5) and both gonadal tumors (OR, 1.7; 95% CI, 1.0–2.7) and extragonadal tumors (OR, 3.8; 95% CI, 2.1–6.5). Nonsyndromic defects specifically were not associated with GCTs. In sex‐stratified analyses, associations were observed among males but not females. Conclusions: These data suggest that males with syndromic birth defects are at an increased risk of pediatric GCTs, whereas males with nonsyndromic defects and females are not at an increased risk. Plain Language Summary: We investigated whether birth defects (such as congenital heart disease or Down syndrome) are linked to childhood germ cell tumors (GCTs), cancers that mainly develop in the ovaries or testes.We studied different types of birth defects (defects that were caused by chromosome changes such as Down syndrome or Klinefelter syndrome and defects that were not) and different types of GCTs.Only chromosome changes such as Down syndrome or Klinefelter syndrome were linked to GCTs.Our study suggests that most children with birth defects are not at an increased risk of GCTs because most birth defects are not caused by chromosome changes. We investigated whether birth defects (like congenital heart disease or Down syndrome) are linked to childhood germ cell tumors (GCTs), cancers that mainly develop in the ovaries or testes. We studied different types of birth defects (defects that were caused by chromosome changes like Down syndrome or Klinefelter syndrome, and defects that were not) and different types of GCTs. Only chromosome changes like Down syndrome or Klinefelter syndrome were linked to GCTs. Our study suggests that most children with birth defects are not at increased risk of germ cell tumors, because most birth defects are not caused by chromosome changes. [ABSTRACT FROM AUTHOR]

Published
2023
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112. The Risks of Birth Defects and Childhood Cancer With Conception by Assisted Reproductive Technology

Author

Luke, Barbara, primary, Brown, Morton B., additional, Wantman, Ethan, additional, Schymura, Maria J., additional, Browne, Marilyn L., additional, Fisher, Sarah C., additional, Forestieri, Nina E., additional, Rao, Chandrika, additional, Nichols, Hazel B., additional, Yazdy, Mahsa M., additional, Gershman, Susan T., additional, Sacha, Caitlin R., additional, Williams, Melanie, additional, Ethen, Mary K., additional, Canfield, Mark A., additional, Doody, Kevin J., additional, Eisenberg, Michael L., additional, Baker, Valerie L., additional, Williams, Carrie, additional, Sutcliffe, Alastair G., additional, Richard, Melissa A., additional, and Lupo, Philip J., additional

Published
2023
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113. Ethnic‐specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high‐dose methotrexate

Author

Harris, Rachel D., primary, Bernhardt, Melanie Brooke, additional, Zobeck, Mark C., additional, Taylor, Olga A., additional, Gramatges, Maria Monica, additional, Schafer, Eric S., additional, Lupo, Philip J., additional, Rabin, Karen R., additional, Scheurer, Michael E., additional, and Brown, Austin L., additional

Published
2023
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115. Patterns of co‐occurring birth defects in children with anotia and microtia

Author

Schraw, Jeremy M., primary, Benjamin, Renata H., additional, Shumate, Charles J., additional, Canfield, Mark A., additional, Scott, Daryl A., additional, McLean, Scott D., additional, Northrup, Hope, additional, Scheuerle, Angela E., additional, Schaaf, Christian P., additional, Ray, Joseph W., additional, Chen, Han, additional, Agopian, A. J., additional, and Lupo, Philip J., additional

Published
2022
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116. Germline Genetic and Treatment-Related Risk Factors for Diabetes Mellitus in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study and St Jude Lifetime Cohorts

Author

Richard, Melissa A., primary, Mostoufi-Moab, Sogol, additional, Rathore, Nisha, additional, Baedke, Jessica, additional, Brown, Austin L., additional, Chanock, Stephen J., additional, Friedman, Danielle N., additional, Gramatges, M. Monica, additional, Howell, Rebecca M., additional, Kamdar, Kala Y., additional, Leisenring, Wendy M., additional, Meacham, Lillian R., additional, Morton, Lindsay M., additional, Oeffinger, Kevin, additional, Robison, Leslie L., additional, Sapkota, Yadav, additional, Sklar, Charles A., additional, Armstrong, Gregory T., additional, Bhatia, Smita, additional, and Lupo, Philip J., additional

Published
2022
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121. Differential newborn DNA methylation among individuals with complex congenital heart defects and childhood lymphoma

Author

Richard, Melissa A., primary, Yang, Wei, additional, Sok, Pagna, additional, Li, Ming, additional, Carmichael, Suzan L., additional, von Behren, Julie, additional, Reynolds, Peggy, additional, Fisher, Paul G., additional, Collins, R. Thomas, additional, Hobbs, Charlotte A., additional, Luke, Barbara, additional, Shaw, Gary M., additional, and Lupo, Philip J., additional

Published
2022
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122. The risks of birth defects and childhood cancer with conception by assisted reproductive technology

Author

Luke, Barbara, primary, Brown, Morton B, additional, Wantman, Ethan, additional, Schymura, Maria J, additional, Browne, Marilyn L, additional, Fisher, Sarah C, additional, Forestieri, Nina E, additional, Rao, Chandrika, additional, Nichols, Hazel B, additional, Yazdy, Mahsa M, additional, Gershman, Susan T, additional, Sacha, Caitlin R, additional, Williams, Melanie, additional, Ethen, Mary K, additional, Canfield, Mark A, additional, Doody, Kevin J, additional, Eisenberg, Michael L, additional, Baker, Valerie L, additional, Williams, Carrie, additional, Sutcliffe, Alastair G, additional, Richard, Melissa A, additional, and Lupo, Philip J, additional

Published
2022
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124. Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe

Author

Hettmer, Simone, primary, Linardic, Corinne M., additional, Kelsey, Anna, additional, Rudzinski, Erin R., additional, Vokuhl, Christian, additional, Selfe, Joanna, additional, Ruhen, Olivia, additional, Shern, Jack F., additional, Khan, Javed, additional, Kovach, Alexander R., additional, Lupo, Philip J., additional, Gatz, Susanne A., additional, Schäfer, Beat W., additional, Volchenboum, Samuel, additional, Minard-Colin, Véronique, additional, Koscielniak, Ewa, additional, Hawkins, Douglas S., additional, Bisogno, Gianni, additional, Sparber-Sauer, Monika, additional, Venkatramani, Rajkumar, additional, Merks, Johannes H.M., additional, and Shipley, Janet, additional

Published
2022
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125. Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

Author

Chakraborty, Rikhia, Hampton, Oliver A., Shen, Xiaoyun, Simko, Stephen J., Shih, Albert, Abhyankar, Harshal, Lim, Karen Phaik Har, Covington, Kyle R., Trevino, Lisa, Dewal, Ninad, Muzny, Donna M., Doddapaneni, Harshavardhan, Hu, Jianhong, Wang, Linghua, Lupo, Philip J., Hicks, M. John, Bonilla, Diana L., Dwyer, Karen C., Berres, Marie-Luise, Poulikakos, Poulikos I., Merad, Miriam, McClain, Kenneth L., Wheeler, David A., Allen, Carl E., and Parsons, D. Williams

Published
2014
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139. The Epidemiology of Biliary Atresia: Exploring the Role of Developmental Factors on Birth Prevalence

Author

Cavallo, Laurel, primary, Kovar, Erin M., additional, Aqul, Amal, additional, McLoughlin, Lucille, additional, Mittal, Naveen K., additional, Rodriguez-Baez, Norberto, additional, Shneider, Benjamin L., additional, Zwiener, Robert J., additional, Chambers, Tiffany M., additional, Langlois, Peter H., additional, Canfield, Mark A., additional, Agopian, A.J., additional, Lupo, Philip J., additional, and Harpavat, Sanjiv, additional

Published
2022
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140. Abstract 3636: Ethnic disparities in methotrexate neurotoxicity during pediatric acute lymphoblastic leukemia therapy: A report from the Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium

Author

Brown, Austin L., primary, Harris, Rachel D., additional, Taylor, Olga A., additional, Bernhardt, Melanie B., additional, Bernini, Juan C., additional, Erana, Rodrigo A., additional, Griffin, Timothy, additional, Heym, Kenneth, additional, Huynh, Van T., additional, Ludwig, Kathleen, additional, Meoded, Avner, additional, Pruitt, Sandi L., additional, Lupo, Philip J., additional, Rabin, Karen R., additional, and Scheurer, Michael E., additional

Published
2022
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141. Abstract 2002: A genome-wide association study identifies novel sepsis risk loci in children with Down syndrome-associated acute lymphoblastic leukemia: A report from the Children’s Oncology Group

Author

Richard, Melissa A., primary, Devidas, Meenakshi, additional, Yang, Wenjian, additional, Woodhouse, John P., additional, Rodriguez, Vilmarie, additional, Hitzler, Johann K., additional, Schore, Reuven J., additional, Angiolillo, Anne L., additional, Burke, Michael J., additional, Salzer, Wanda L., additional, Raetz, Elizabeth A., additional, Loh, Mignon L., additional, Hunger, Stephen P., additional, Yang, Jun J., additional, Lupo, Philip J., additional, and Rabin, Karen R., additional

Published
2022
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145. Abstract 3633: Disparities in relapse among a large multi-ethnic population of children diagnosed with acute lymphoblastic leukemia (ALL): A report from the Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium

Author

Sok, Pagna, primary, Brown, Austin L., additional, Taylor, Olga A., additional, Bernhardt, M. Brooke, additional, Bernini, Juan C., additional, Erana, Rodrigo A., additional, Griffin, Timothy, additional, Heym, Kenneth, additional, Huynh, Van T., additional, Klesse, Laura, additional, Ludwig, Kathleen, additional, Pruitt, Sandi L., additional, Rabin, Karen R., additional, Scheurer, Michael E., additional, and Lupo, Philip J., additional

Published
2022
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147. Abstract 683: Identification of common germline variants associated with pediatric rhabdomyosarcoma survival: A report from the Children's Oncology Group (COG)

Author

Martin-Giacalone, Bailey A., primary, Scheurer, Michael E., additional, Khan, Javed, additional, Chanock, Stephen J., additional, Li, Shengchao Alfred, additional, Yeager, Meredith, additional, Marquez-Do, Deborah A., additional, Barkauskas, Donald A., additional, Hall, David, additional, McEvoy, Matthew T., additional, Richard, Melissa A., additional, Sok, Pagna, additional, Brown, Austin L., additional, Sabo, Aniko, additional, Skapek, Stephen X., additional, Hawkins, Douglas S., additional, Venkatramani, Rajkumar, additional, Mirabello, Lisa, additional, and Lupo, Philip J., additional

Published
2022
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