Search

O presente artigo tem o objetivo de investigar se o constitucionalismo tem sido utilizado abusivamente para encobrir decisões do Supremo Tribunal Federal com motivações ideológicas ou que favorecem determinados atores políticos, o que se denomina de fulanização de julgamentos. Para atingir seu escopo, a pesquisa se desenvolve com base em uma linha crítico-metodológica e a partir de uma metodologia de investigação histórico-jurídica, a partir do marco teórico do constitucionalismo abusivo, com base em casos julgados pela Corte no período de 2013 a 2018. Ao final, conclui-se que, em diversas situações, o direito constitucional foi utilizado pelo Supremo Tribunal Federal apenas para justificar ou dar aparência de legitimidade a decisões, que, em verdade, possuem natureza eminentemente política, bem como que a fulanização de julgamentos pode minar a própria razão democrática da atuação judicial em matéria de política e corroer a expectativa de que a Corte Constitucional brasileira seja a guardiã da ordem constitucional, do Estado de Direito e da democracia.

Este estudo tem por objetivo analisar, à luz da Pedagogia Histórico-crítica (PHC), a Educação Ambiental (EA) no Currículo de Referência de Mato Grosso do Sul (CRMS). De modo mais específico, investigamos onde e como ela se insere, principalmente sua relação com os conteúdos curriculares. Tendo como referencial teórico e metodológico o Materialismo Histórico e Dialético desenvolvemos um estudo exploratório cuja busca de informações foi realizada no citado currículo. As análises foram realizadas por meio de uma “categoria síntese”, a relação conteúdo-forma, com a qual foi possível partir empiricamente para, a partir das abstrações, compreender criticamente a EA no CRMS. Entre os resultados, entendemos que a dissociação entre conteúdo-forma encontrada no currículo implica a possibilidade de incompreensão, por alunos e professores, da crise socioambiental enquanto síntese de múltiplas determinações que têm origem no modo capitalista de produção. Em virtude disso, abre-se espaço para uma compreensão da EA enquanto Educação para o Desenvolvimento Sustentável (EDS), expressão da ideologia neoliberal, do ambientalismo de resultados, do pragmatismo contemporâneo e do ecologismo de mercado.

Nesta pesquisa, foram investigados trabalhos publicados no ENPEC e no ENEBIO relacionados ao ensino de evolução biológica e formação de professores. Identificaram-se 21 trabalhos sobre a temática, que foram analisados por meio da Análise de Conteúdo. Oito categorias temáticas constituíram o foco dos estudos relacionados à evolução biológica: a) concepções conceituais; b) dificuldades no ensino; c) estratégias didáticas; d) possibilidades no ensino; e) cursos de formação; f) epistemologia; g) evolucionismo e religião; e h) importância da evolução biológica. Com isso, percebe-se que as dificuldades e os equívocos relacionados aos conceitos evolutivos são frequentes, e que a formação está diretamente relacionada a esses desafios, pela fragmentação do conteúdo e escassez nas discussões sobre natureza da ciência e crenças religiosas.

O estudo teve como objetivo conhecer as experiências de mães e médicos em relação ao comunicado do diagnóstico da síndrome de Down (SD). Trata-se de uma pesquisa exploratória e transversal, com delineamento qualitativo. Participaram 9 mães e 7 médicos. Foram realizadas 16 entrevistas semiestruturadas individuais. Os dados foram transcritos e submetidos à análise de conteúdo temática. Constatou-se que, para mães e médicos, é uma experiência complexa e difícil, permeada por sentimentos ambivalentes. Nas mães, predominam a tristeza, medo e angústia. A maioria delas sentiram-se insatisfeitas na maneira como receberam o diagnóstico, isso foi atribuído por elas e pelos médicos à falta de preparo durante a formação profissional. Conclui-se que algumas sugestões podem nortear a comunicação do diagnóstico, no intuito de favorecer a elaboração do mesmo, a saber: respeitar o tempo para a mãe observar e conhecer o bebê antes de receber o diagnóstico, comunicar a mãe com sensibilidade e empatia, preferencialmente na presença do outro genitor e de um psicólogo, procurar dar ênfase aos aspectos positivos da saúde do bebê.

Introduction: Non-melanoma tumors frequently affect the lower palpebral region and constitute a challenge for reconstructing the surgical wound without causing functional or aesthetic changes. Primary closure is generally impossible, and flaps are preferred over grafts as they generate less eyelid retraction. This article aims to describe a new surgical reconstruction technique. Method: A modified McGregor flap technique is described for correcting a surgical defect greater than 50% of the anterior lamella of a recurrent basal cell carcinoma lesion in the lower eyelid. Results: The patient was evaluated on the 7th, 14th, 21st, and 45th postoperative days. She presented a good functional and aesthetic response to the technique used. Conclusion: Using the double transposition flap, we demonstrate a new technique for closing defects larger than two-thirds in the lower eyelid.

RESUMO Diversos pesquisadores têm buscado compreender o que leva os indivíduos a cumprir as Políticas de Segurança da Informação - PSIs instituídas pelas organizações. Uma dessas correntes defende que a cultura representa um importante fator, destacando-se a presença de estudos envolvendo cultura organizacional em detrimento da cultura nacional. Dadas as especificidades culturais do país, estudar a relação entre seus aspectos culturais e o cumprimento das PSIs pode trazer insights sobre a gestão da segurança da informação nas organizações brasileiras. Assim, objetivou-se neste estudo analisar como a cultura de segurança da informação influencia os indivíduos no cumprimento das políticas de segurança da informação e na diminuição da ocorrência de falhas de segurança associadas ao “jeitinho brasileiro”. O estudo caracteriza-se como uma pesquisa survey aplicada a 196 funcionários de diferentes organizações brasileiras. Os resultados indicaram que a consciência de segurança da informação influencia positivamente o comportamento planejado dos indivíduos e negativamente o “jeitinho”, sendo que ambos influenciam o cumprimento das normas de segurança da informação estabelecidas pela organização. Identificou-se, ainda, uma forte relação entre o cumprimento das normas e a diminuição de falhas de segurança associadas ao “jeitinho brasileiro”.

Abstract The food enzyme catalase (hydrogen‐peroxide:hydrogen‐peroxide oxidoreductase; EC 1.11.1.6) is produced with the non‐genetically modified Aspergillus tubingensis strain AE‐CN by Amano Enzyme Inc. The absence of viable cells of the production organism in the food enzyme was not demonstrated. The food enzyme is intended to be used in five food manufacturing processes: production of baked products, processing of egg and egg products, production of fruit and vegetable products other than juices, production of cheese and production of fish roes. The dietary exposure to the food enzyme total organic solids (TOS) was estimated to be up to 0.325 mg TOS/kg body weight (bw) per day in European populations. The results of the in vitro genotoxicity studies indicated the presence of a clastogenic agent in the food enzyme which could not be dismissed due to limitations in the in vivo studies. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 323 mg TOS/kg bw per day, the highest dose tested. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and one match was found. The Panel considered that the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. Because of the results of the genotoxicity studies, and as the absence of viable cells from the production strain was not demonstrated, the Panel was unable to establish the safety of the food enzyme.

Abstract The food enzyme α‐l‐rhamnosidase (α‐l‐rhamnoside rhamnohydrolase; EC 3.2.1.40) is produced with the non‐genetically modified Penicillium adametzii strain AE‐HP by Amano Enzymes Inc. The food enzyme is considered free from viable cells of the production organism. It is intended to be used in the processing of fruits and vegetables for the production of juices and other fruit products. The dietary exposure to the food enzyme‐TOS was estimated to be up to 0.022 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 300 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated dietary exposure, results in a margin of exposure of at least 13,636. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

Abstract The food enzyme glucan 1,4‐α‐maltohydrolase (4‐α‐D‐glucan α‐maltohydrolase EC 3.2.1.133) is produced with the genetically modified Bacillus subtilis strain AR‐513 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in four food manufacturing processes: processing of cereals and other grains for the production of baked products, other cereal‐based products and glucose syrups and other starch hydrolysates; processing of plant‐ and fungal‐derived products for the production of plant‐based analogues of milk and milk products. Since residual amounts of total organic solids (TOS) are removed in the production of glucose syrups and other starch hydrolysates, dietary exposure was not calculated for this process. For the remaining three food processes, exposure to the food enzyme‐TOS was estimated to be up to 0.2 μg TOS/kg body weight per day in European populations. As the production strain of B. subtilis strain AR‐513 meets the requirements for the qualified presumption of safety (QPS) approach and no issue of concern arose from the production process, no toxicological data were required. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and five matches with respiratory allergens and one with a mosquito allergen were found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme did not give rise to safety concerns, under the intended conditions of use.

Abstract The food enzyme endo‐polygalacturonase ((1→4)‐α‐D‐galacturonan glycanohydrolase (endo‐cleaving); EC 3.2.1.15)) is produced with the non‐genetically modified Aspergillus tubingensis strain MUCL 55013 by Soufflet Biotechnologies. The food enzyme is free from viable cells of the production organism. It is intended to be used in 10 food manufacturing processes: processing of fruits and vegetables for the production of juices, other fruit and vegetable products, wine, distilled spirits from wine, alcoholic beverages other than grape wine; processing of plant‐derived products for the production of refined and unrefined sugar, edible oils from plants, green coffee beans by demucilation, coffee extracts and tea and other herbal and fruit infusions. Since residual amounts of total organic solids (TOS) are removed in three processes, dietary exposure was calculated only for the remaining seven food manufacturing processes. Exposure was estimated to be up to 7.834 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 2,097 mg TOS/kg bw per day, the highest dose tested, resulting in a margin of exposure of at least 268. A search for the similarity of the amino acid sequence of the food enzyme to known allergens found 14 matches, one of which was to a food allergen. The Panel considered that the risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded, in particular for individuals sensitised to papaya, but that the risk will not exceed that of consumption of papaya. In addition, oral allergy reactions cannot be excluded in pollen‐sensitised individuals. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

Este estudo objetiva compreender a concepção de educação inclusiva e a forma como as políticas educacionais são interpretadas e traduzidas pelos atores políticos profissionais responsáveis pela Educação Especial (PREEs) das Coordenadorias Regionais de Educação (CREs) que atuam em diferentes contextos na Rede Estadual de Ensino de Santa Catarina (REE/SC) na garantia do direito à educação estudantes com Deficiência Intelectual (DI). Os dados construídos derivam do recorte de um questionário aberto aplicado aos PREEs das 36 CREs e entrevista realizada com uma parte desses profissionais. Os dados foram analisados com base na Teoria da Atuação Política e articulados com os documentos políticos que orientam a perspectiva de educação inclusiva em SC. Os resultados apontam que a REE/SC fez grandes avanços no que se refere aos documentos orientadores e serviços disponibilizados garantindo o acesso à escola. No entanto, destacam a insuficiência e fragilidade na formação inicial e continuada dos atores políticos envolvidos no processo. Consideram ainda que a atuação das políticas educacionais não estão garantindo efetivamente o direito à educação aos estudantes com DI gerando ainda processos de exclusão dentro da escola com as barreiras impostas.

Este trabalho objetivou identificar conceitos fundamentais no ensino de Ecologia para os anos finais do ensino fundamental, a fim de contribuir para a reflexão sobre a construção de um currículo que tenha como foco a socialização dos saberes científicos, preconizado pela pedagogia histórico-crítica. Foram realizadas entrevistas semi-estruturadas com especialistas da área de estudo da Ecologia e análise da Base Nacional Comum Curricular. Como resultados temos que “interações ecológicas” e “conservação” são conceitos em comum nas duas fontes pesquisadas e em um processo de depuração dos conceitos indicados, entende-se “interações ecológicas” um conceito fundamental dentro do ensino da Ecologia e “conservação” uma consequência do processo de ensino e aprendizagem dos demais conceitos da Ecologia.

Este trabalho apresenta um estado do conhecimento sobre a atuação da coordenação pedagógica na educação básica, como metodologia, optou-se por desenvolver um Estado do Conhecimento, que se caracteriza como um tipo de pesquisa bibliográfica, que averigua e analisa as pesquisas de uma determinada área do conhecimento, com intuito de estabelecer o seu estado corrente (MOROSINI; KOHLS-SANTOS; BITTENCOURT, 2021).“Coordenação Pedagógica and educação básica” e “coordenação pedagógica and desenvolvimento profissional”, na base de dados BDTD – Biblioteca Brasileira Digital de Teses e Dissertações, com um recorte temporal de 2015 a 2022, foram encontrados 177 dissertações, após a análise inicial foram elencadas 8 para uma análise mais detalhada. Assim, permitirá saber o que vem sendo pesquisado a respeito da temática atuação da coordenação pedagógica na educação básica. Os resultados afirmam: a coordenação pedagógica precisa definir seu espaço papel/lugar na gestão escolar, pois encontra-se sobrecarregada. Através da análise qualitativa destes trabalhos conclui-se, é emergente construir novas formas de pensar e fazer a atuação da coordenação pedagógica. Palavras-chave: Gestão Democrática. Gestão Escolar. Coordenação Pedagógica.

O objetivo deste estudo é relatar a experiência resultante do projeto de extensão Rówaihu’úTé, com técnicos de enfermagem que atuam na atenção à saúde indígena no estado de Mato Grosso. O projeto de extensão Rówaihu’úTé foi desenvolvido na Universidade Federal de Mato Grosso (UFMT), Campus Universitário do Araguaia, entre março e dezembro de 2018, com participação de 80 técnicos de enfermagem indígenas e não-indígenas, divididos em 4 grupos. Cada grupo participou de 40 horas-aula de formação, abordando os temas: saúde da mulher, saúde da criança, primeiros socorros, suporte básico de vida, Leishmaniose, princípios da Assistência de Enfermagem, ética, bioética e biossegurança. Os temas do curso foram abordados numa perspectiva metodológica participativa, problematizadora e reflexiva, reconhecendo as iniciativas, experiências profissionais e de vida dos participantes. Esta experiência de educação permanente, além de capacitar os técnicos de enfermagem que prestam assistência à saúde Xavante, também capacitou indiretamente os educadores, ao qualificar suas práticas formativas no contexto intercultural, aprimorar habilidades que favoreçam a comunicação e permitam conhecer a realidade dos povos indígenas e, ainda, o desenvolvimento de estratégias de ensino e de atenção à saúde culturalmente referenciadas. Palavras-chave: Educação em enfermagem; Povos indígenas; Saúde de Populações Indígenas Rówaihu’úté - Qualification of nursing technicians working in indigenous territory Abstract: The objective of this study is to report the experience resulting from the Rówaihu’úTé extension project with nursing technicians who work in indigenous health care in the state of Mato Grosso. The project Rówaihu'úTé, developed at the Federal University of Mato Grosso, University Campus of Araguaia, between March and December 2018, with the participation of 80 indigenous and non-indigenous nursing technicians, divided into four groups. Each group participated in 40 hours of training classes, addressing the themes: women's health, children's health, first aid, basic life support, Leishmaniasis, Nursing Care principles, ethics, bioethics, and biosafety. The course themes were addressed from a participatory, problematizing, and reflective methodological perspective, recognizing the initiatives and professional and life experiences of the participants. This permanent education experience, in addition to training the nursing technicians who provide Xavante health care, also indirectly trained the educators by qualifying their training practices in the intercultural context and improving skills that favor communication and allow them to know the reality of indigenous peoples and, yet, the development of culturally referenced teaching and health care strategies. Keywords: Nursing education; Indigenous people; Health of Indigenous Populations

Abstract Objective This study aimed to evaluate whether the use of desensitizing dentifrices containing obliterating agents can affect bond strength of eroded/abraded dentin. Methodology A total of 100 dentin samples were obtained from human molars. The teeth were cut into 3 mm-thickness discs and allocated in five groups (n=20), according to the toothpaste used: WoF – abrasion with fluoride-free toothpaste (Cocoricó); Arg – toothpaste containing arginine (Colgate Sensitive Pro-Relief); Nov – calcium sodium phosphosilicate toothpaste (Sensodyne Repair and Protect); SnF – fluoride-containing toothpaste (AmF/SnCl2/SnF2 – Elmex Erosion); and Control (no erosive/abrasive process). The erosive/abrasive cycle consisted of immersion in citric acid (1%, pH 2.6, 5 min, 4×/day) and abrasion (2×/day, 120–20 sec abrasion, 100 sec immersion) with each toothpaste. During intervals, samples were immersed in artificial saliva. This cycle was performed for five days. Two resin cylinders (2 mm in diameter) were constructed on each sample for the shear bond strength test using a universal adhesive system. The self-etch and etch-and-rinse (Scotchbond Universal) strategies were employed, each in half of the total sample (n=10). Bond strength (MPa) was measured in a shear test and failure modes were assessed with a stereomicroscope. Statistical analysis was performed using the two-way analysis of variance (ANOVA) and Tukey tests (p

Penelitian ini bertujuan untuk menunjukkan bahwa Alkitab merupakan ingatan kanonik. Berbeda dengan Michael Welker yang telah menunjukkan bahwa Perjamuan Kudus dalam Perjanjian Baru merupakan ingatan kanonik, tulisan ini menunjukkan bahwa seluruh Alkitab yaitu Perjanjian Lama dan Perjanjian Baru merupakan ingatan kanonik yang terus dikomunikasikan oleh umat di segala zaman dan tempat. dengan objek ingatan perjanjian sehingga umat Tuhan di segala zaman dan tempat mengomunikasikan ingatan perjanjian dalam komunitasnya. Dengan melakukan studi pustaka untuk menemukan kaitan antara teologi dengan ingatan budaya, maka tulisan ini membahas pemikiran Michael Welker dan Jan Assmann. Penelitian ini menemukan bahwa Alkitab merupakan ingatan budaya yang mendapat tambahan nilai iman sehingga menjadi ingatan kanonik. Selain Alkitab, ingatan kanonik juga ditemukan dalam sistem kepercayaan masyarakat tradisional. Perbedaan Alkitab dengan sistem kepercayaan masyarakat tradisional bukan berada dalam ingatan kanonik tetapi dalam obyek perjanjian di Alkitab. Tulisan ini menemukan bahwa Gereja sebagai komunitas penerima perjanjian, memiliki ingatan perjanjian sebagai ingatan khusus yang hanya dikomunikasikan dan dimiliki oleh umat Tuhan.

The effectiveness of network intrusion detection systems, predominantly based on machine learning, is highly influenced by the dataset they are trained on. Ensuring an accurate reflection of the multifaceted nature of benign and malicious traffic in these datasets is paramount for creating IDS models capable of recognizing and responding to a wide array of intrusion patterns. However, existing datasets often fall short, lacking the necessary diversity and alignment with the contemporary network environment, thereby limiting the effectiveness of intrusion detection. This paper introduces TII-SSRC-23, a novel and comprehensive dataset designed to overcome these challenges. Comprising a diverse range of traffic types and subtypes, our dataset is a robust and versatile tool for the research community. Additionally, we conduct a feature importance analysis, providing vital insights into critical features for intrusion detection tasks. Through extensive experimentation, we also establish firm baselines for supervised and unsupervised intrusion detection methodologies using our dataset, further contributing to the advancement and adaptability of IDS models in the rapidly changing landscape of network security. Our dataset is available at https://kaggle.com/datasets/daniaherzalla/tii-ssrc-23.

Resenha do Livro: PAULA, João Antônio de. Capítulos de história do pensamento econômico do Brasil. Prefácio: Maria Alice Rosa Ribeiro. São Paulo: Hucitec: ABPHE, 2021.

Model predictive control (MPC) is a powerful and widely used technique to address the control challenges in power converters as the grid interface for renewable energy systems. This technique combines closed-loop control with error and control effort minimization; however, its design is challenging, and we know little about how the controller parameters affect the closed-loop performance of grid-connected voltage source converters. In this study, we applied an MPC direct power control with modulation for a grid-connected power converter with an inductive filter. For the controller design, we proposed an initial set based on the power converter’s nominal setup. Then, we define the range of settings to guarantee stability by analyzing the closed-loop poles of the system. The fine-tuning to improve the performance can be identified visually using the performance maps built from simulations of the control system, simultaneously sweeping the time horizons of the predictive model and the weight factors of the cost function. Experimental results on a low-power bench demonstrate the excellent performance of the designed controller, following and even outperforming the classical proportional-integral (PI) controller and other advanced control techniques.

Introduction and objective: The Bronchiectasis Health Questionnaire (BHQ) is a simple, repeatable, and self-reporting health status questionnaire for bronchiectasis. This study aims to cross-culturally adapt the BHQ into Brazilian Portuguese and evaluate its measurement properties. Methods: The participants answered the Saint George...s Respiratory Questionnaire (SGRQ) and the modified Medical Research Council (mMRC) scale for dyspnea. The Brazilian-Portuguese version of the Bronchiectasis Health Questionnaire (BHQ-Brazil) was used at baseline (test) and after 14 days (retest). The psychometric analyses included internal consistency, test-retest reliability, and construct validity: factorial validity, convergent validity, and discriminative validity, agreement, and ceiling and floor effects. Results: The BHQ-Brazil demonstrated adequate internal consistency (Cronbach...s alpha...=...0.92) and substantial reliability (intraclass correlation coefficient...=...0.86; 95%CI: 0.79...0.90). The exploratory factorial analysis was considered suitable. All items presented a factorial load >0.40. The convergent validity of the BHQ-Brazil with mMRC was moderate (r...=......0.53, p...

ABSTRACT The use of support devices may facilitate the perception of pelvic floor muscle (PFM) contraction, which is difficult to be performed. Therefore, this study aimed to compare the perception of PFM contraction in the sitting position during the use of two different support devices on women with PFM dysfunction. This is a cross-sectional study performed with 37 women with stress or mixed urinary incontinence (UI). All women performed three free PFM contractions sitting on a chair, followed by three contractions using each support device (sand pads and a cylindrical foam, which provide sciatic and perineal support, respectively). Women scored the perception of PFM contraction from 1 to 5, as well as the perception of facilitation of contraction (higher grades show better results) and discomfort (higher grades show more discomfort) when compared with free contraction. The cylindrical foam presented similar results to sand pads for the perception of PFM contraction (2.84±1.61 vs. 3.19±1.43; p=0.34) and facilitation of contraction (3.38±1.34 vs. 3.19±1.54; p=0.61), as well as for their discomfort (1.83±1.23 vs. 1.5±1.16; p=0.20). Of all women, 57% preferred sand pads. Thus, both sand pads (sciatic support) and the cylindrical foam (perineal support) improved the perception of PFM contraction and facilitation of contraction in the sitting position of women with PFM dysfunction when compared with sitting with no device. The two devices presented no difference between them.

Background: In 2007, skin cancers were third most common malignancies in Indonesia. However, profile of cutaneous tumors in our institution has not been studied. Purpose: To evaluate profile of cutaneous tumors in Dermatology and Venerology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya, Indonesia. Methods: This is a descriptive retrospective study. Inclusion criteria was new cutaneous tumor patients. Exclusion criteria was incomplete data. Medical record and photograph database from 2019-2020 were assessed for demography, clinical features, histopathological examination and final diagnosis. Results: There were 379 (5,5%) cutaneous tumors among 6896 new patients at Dermatology and Venereology Outpatient Clinic. Overall, there were more female patients (53.7%) and age group of 0-45 years old (70.4%). Cutaneous tumors more commonly presented as papular (50.4%), multiple (56.5%), nonpigmented (58.3%), asymptomatic lesions (62.5%), with time from onset 0-24 months (66.2%) and location on head and face (61.2%). Benign cutaneous tumors showed similar findings. Malignant cutaneous tumors showed differences including predominantly male sex, age above 45 years old, nodular, solitary, pigmented and easily bleeding lesions. Malignant tumors were less common (6.9%). Most common malignant tumor was BCC. Most common benign and overall cutaneous tumor was seborrheic keratosis. Conclusion: Cutaneous tumors presented across gender and ages, showing heterogenous clinical manifestations. Malignant and benign cutaneous tumors showed similarity on time from onset and location of lesions. However, differences were seen in demographic profiles and majority of clinical features. BCC was the most common malignant cutaneous tumors, while seborrheic keratosis was the most common benign and overall cutaneous tumors.

Abstract Background Diabetes Mellitus (DM) affects a third of patients with symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI). DM is a well-known risk factor for cardiac surgery, but its prognostic impact in TAVI patients remains controversial. This study aimed to evaluate outcomes in diabetic patients undergoing TAVI. Methods This multicentre registry includes data of > 12,000 patients undergoing transfemoral TAVI. We assessed baseline patient characteristics and clinical outcomes in patients with DM and without DM. Clinical outcomes were defined by the second valve academic research consortium. Propensity score matching was applied to minimize potential confounding. Results Of the 11,440 patients included, 31% (n = 3550) had DM and 69% (n = 7890) did not have DM. Diabetic patients were younger but had an overall worse cardiovascular risk profile than non-diabetic patients. All-cause mortality rates were comparable at 30 days (4.5% vs. 4.9%, RR 0.9, 95%CI 0.8–1.1, p = 0.43) and at one year (17.5% vs. 17.4%, RR 1.0, 95%CI 0.9–1.1, p = 0.86) in the unmatched population. Propensity score matching obtained 3281 patient-pairs. Also in the matched population, mortality rates were comparable at 30 days (4.7% vs. 4.3%, RR 1.1, 95%CI 0.9–1.4, p = 0.38) and one year (17.3% vs. 16.2%, RR 1.1, 95%CI 0.9–1.2, p = 0.37). Other clinical outcomes including stroke, major bleeding, myocardial infarction and permanent pacemaker implantation, were comparable between patients with DM and without DM. Insulin treated diabetics (n = 314) showed a trend to higher mortality compared with non-insulin treated diabetics (n = 701, Hazard Ratio 1.5, 95%CI 0.9–2.3, p = 0.08). EuroSCORE II was the most accurate risk score and underestimated 30-day mortality with an observed-expected ratio of 1.15 in DM patients, STS-PROM overestimated actual mortality with a ratio of 0.77 and Logistic EuroSCORE with 0.35. Conclusion DM was not associated with mortality during the first year after TAVI. DM patients undergoing TAVI had low rates of mortality and other adverse clinical outcomes, comparable to non-DM TAVI patients. Our results underscore the safety of TAVI treatment in DM patients. Trial registration The study is registered at clinicaltrials.gov (NCT03588247).

Este artigo apresenta os resultados do primeiro estudo realizado no âmbito do projeto de pesquisa em desenvolvimento no curso de Doutorado em Educação, no PPGE/Faed/Udesc, que objetiva “Compreender pela perspectiva de mulheres com deficiência, como são representados os princípios da ética do cuidado no enfrentamento ao capacitismo no Ensino Superior”. Como aporte teórico pautou-se nos Estudos Emancipatórios da Deficiência que contemplam, em toda a sua amplitude, os princípios anticapacitistas, partindo do princípio de investigar COM as mulheres com deficiência, não SOBRE elas. Este estudo de cunho qualitativo, caracterizou-se como uma revisão integrativa da literatura e objetivou analisar as produções científicas que tenham, como foco de pesquisa, as mulheres com deficiência nas Instituições de Ensino Superior, no período de 2016 a 2020. Utilizou-secomo base de dados, o Portal da Capes, a Revista de Educação Especial/UFSM e a Plataforma Google Acadêmico e, definiu-se,após aplicação dos critérios de inclusão, o total de 10 produções analisadas. Os resultados obtidos revelaram: a) baixa produção científica e de artigos sobre o grupo foco deste estudo; b) predominância do “capacitismo” na produção científica, ainda que não valorizado na maioria dos artigos analisados; e c) presença da interseccionalidade como epistemologia de base em algumas produções. Esses achados atestam o desafio político e ético envolvido nas pesquisas sobre e com as mulheres com deficiência nas Instituições de Ensino Superior e a necessidade de mobilizar e articular uma rede de pesquisadores para convergir esforços em favor desse grupo oprimido de forma sobreposta, tanto pelo gênero quanto pela deficiência.

ABSTRACT Objective To assess the predictive value of preoperative serum laboratory test results for identifying choledocholithiasis and reduce the use of cholangioresonance and its inherent costs. Methods Patients aged 21-69 years who underwent preoperative cholangioresonance examination at our institute were included. Patients with a history of fluctuating jaundice or biliary pancreatitis, bile duct dilatation on ultrasonography, and elevated levels of canalicular enzymes (alkaline phosphatase >100U/L and gamma-glutamyl transferase >50U/L) underwent cholangioresonance-guided surgery. Cases of choledocholithiasis confirmed by cholangioresonance were compared with those without choledocholithiasis. Serum laboratory data were evaluated and the diagnostic capabilities of these examinations were analyzed. Results A total of 104 patients were included. For detecting choledocholithiasis using alkaline phosphatase, the cut-off point was 78U/L, sensitivity was 97.6% (95%CI: 87.4-99.9), and specificity was 72.6% (95%CI: 59.8-83.1). In the binary logistic regression analysis, age (OR= 0.92; 95%CI: 0.86-0.98) and alkaline phosphatase level (OR= 1.02; 95%CI: 1.01-1.05) were selected for the final model. Conclusion Serum alkaline phosphatase levels may aid preoperative diagnosis of asymptomatic choledocholithiasis. After a global clinical assessment of the patient, serum laboratory findings may contribute to a reduction in cholangioresonance-related heathcare costs.

BackgroundPrevious research has suggested that most adults improve their asthma control after a short-term behavioral intervention program to increase physical activity in daily life (PADL). However, the characteristics of individuals who respond and do not respond to this intervention and the medium-term response remain unknown. ObjectiveThis study aims to (1) identify the characteristics of adult responders and nonresponders with asthma to a behavioral intervention to increase physical activity and (2) evaluate the functional and clinical benefits in the medium term. MethodsThis prospective pragmatic study will include adults with moderate to severe asthma who enroll in a behavioral intervention. All individuals will receive an educational program and an 8-week intervention to increase PADL (1 time/wk; up to 90 min/session). The educational program will be conducted in a class setting through group discussions and video presentations. Behavioral interventions will be based on the transtheoretical model using counseling, incentives, and individual feedback aiming to increase participation in physical activity. Motivational interviewing and guidelines for overcoming barriers will be used to stimulate individuals to reach their goals. Pre- and postintervention assessments will include the following: PADL (triaxial accelerometry), body composition (octopolar bioimpedance), barriers to PADL (questionnaire), clinical asthma control (Asthma Control Questionnaire), quality of life (Asthma Quality of Life Questionnaire), anxiety and depression levels (Hospital Anxiety and Depression Scale), and exacerbations. “Responders” to the intervention will be defined as those who demonstrate an increase in the number of daily steps (≥2500). ResultsIn December 2021, the clinical trial registration was approved. Recruitment and data collection for the trial is ongoing, and the results of this study are likely to be published in late 2024. ConclusionsThe intervention will likely promote different effects according to the clinical characteristics of the individuals, including asthma control, age, anxiety and depression levels, obesity, and several comorbidities. Identifying individuals who respond or do not respond to behavioral interventions to increase PADL will help clinicians prescribe specific interventions to adults with asthma. Trial RegistrationClinicalTrials.gov NCT05159076; https://clinicaltrials.gov/ct2/show/NCT05159076 International Registered Report Identifier (IRRID)DERR1-10.2196/49032

Abstract The food enzyme endo‐1,4‐β‐xylanase (4‐β‐d‐xylan xylanohydrolase, EC 3.2.1.8) is produced with the non‐genetically modified microorganism Aspergillus tubingensis strain LYX by DSM Food Specialties B.V. The food enzyme was considered free from viable cells of the production organism. It is intended to be used in baking processes and cereal‐based processes. Dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.106 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 227 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 2,142. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

Abstract The food enzyme glucan‐1,4‐α‐maltohydrolase (4‐α‐d‐glucan α‐maltohydrolase; EC 3.2.1.133) is produced with the genetically modified Bacillus subtilis strain AR‐453 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in baking processes. Dietary exposure was estimated to be up to 0.262 mg TOS/kg body weight per day in European populations. As the production strain of B. subtilis strain AR‐453 qualifies for the qualified presumption of safety (QPS) approach to safety assessment and no issue of concern arose from the production process, no toxicological data were required. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and six matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

Abstract The food enzyme ribonuclease P (EC 3.1.26.5) is produced with the non‐genetically modified Penicillium citrinum strain AE‐RP‐4 by Amano Enzyme Inc. It is intended to be used in yeast processing only for the production of yeast extract. Dietary exposure to the food enzyme total organic solids (TOS) was estimated to be up to 0.153 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise safety concerns. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level (NOAEL) of 134.7 mg TOS/kg bw per day, which when compared with the estimated dietary exposure, resulted in a margin of exposure of at least 880. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

Abstract The food enzyme with the declared activities endo‐polygalacturonase ((1–4)‐α‐D‐galacturonan glycanohydrolase; EC 3.2.1.15) and pectin lyase ((1–4)‐6‐O‐methyl‐α‐D‐galacturonan lyase; EC 4.2.2.10) is produced with the non‐genetically modified Aspergillus tubingensis strain NZYM‐PE by Novozymes A/S. It is intended to be used in four food manufacturing processes: fruit and vegetable processing for juice production, fruit and vegetable processing for products other than juices, refined olive oil production and wine and wine vinegar production. Since residual amounts of total organic solids (TOS) are removed during production, dietary exposure was not calculated for refined olive oil production. For the remaining three food processes, it was estimated to be up to 0.132 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level (NOAEL) of 1,430 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, resulted in a margin of exposure above 10,833. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and 13 matches were found, including one food allergen (papaya). The Panel considered that, under the intended conditions of use, the risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded, in particular for individuals sensitised to papaya, but that the risk will not exceed that of consumption of papaya. In addition, oral allergy reactions cannot be excluded in pollen‐sensitised individuals. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer type in children and accounts for 80% of pediatric leukemias. Novel targets are necessary to improve survival rates for refractory and relapsed disease. There is accumulating evidence that Toll-like Receptor (TLR) signaling may be associated with outcomes in cancer however little has been described in leukemias. Objective: Analyze the expression and contribution of TLRs to the development of childhood ALL. Method: To evaluate the effect of specific TLR2, TLR3, and TLR4 agonists on the viability and proliferation of childhood ALL cell lines and to analyzed the mRNA expression of these types of TLR in bone marrow blast cells at diagnosis (D0) and induction (D35) in pediatric ALL patients. Results: Treatment with TLR agonists reduced the cell viability of Jurkat and Sup-B15 cell lines. Cell cycle distribution in Jurkat was altered, reducing polyploid cells and increasing sub-G1 phase. Conclusion: It was observed that the cell viability of the cell lines responded with different sensitivities to the agonists. The polyploidy associated with tumor malignancy was reduced, in addition to the increase in the sub-G1 phase indicating an increase in apoptosis. There were differences in TLR expression at D35 between groups at risk of the disease. Patients with high expression of TLR2 and low expression of TLR4 on D35 demonstrated a worse prognosis.

O presente artigo tem como objetivo analisar criticamente as políticas e práticas que visam assegurar o direito à educação no contexto angolano agora (durante a pandemia da Covid-19) e depois (nova normalidade) em correlação com os impactos do antigo normal. Desse modo, a pesquisa é metodologicamente qualitativa do tipo documental, com alcance exploratório-descritivo, fazendo análise de documentos oficias e pesquisas nacionais e internacionais sobre todos os indicadores considerados nesse estudo. Os resultados evidenciam que, para além dos avanços conseguidos no capítulo do direito à educação para todos, o país enfrenta sérias dificuldades em estendê-lo para todos, dificuldades que ficaram muito patentes durante a pandemia da Covid-19, incluindo sua privação por conta da precariedade e sucateamento da educação em tempos normais.

Este artigo faz parte da pesquisa do Mestrado Profissional do PPGE/UFSM. O estudo objetivou: (i) promover Círculos Dialógicos Investigativo-Formativos em uma EMEF, na perspectiva de processos auto(trans)formativos à Educação Infantil no Projeto Político-Pedagógico; (ii) elaborar, no decorrer dos Círculos, Elementos Orientadores para a [re]significação do PPP. Trata-se de uma pesquisa de abordagem qualitativa (MINAYO, 2009) e análise documental. Realizou-se os Círculos Dialógicos (HENZ, 2015) e a hermenêutica filosófica (HERMANN, 2002) para interpretação dialógica. O referencial teórico está embasado nos marcos legais, em (IMBERNÓN, 2011), (FREIRE, 2021) entre outros. Como resultado foram criados os Elementos a partir da dialogicidade das coautoras: objetivos da EI; concepção de EI, criança, infância, inclusão e proposta pedagógica; organização dos tempos e espaços; avaliação e formação em contexto. Constatou-se que por meio dos Círculos Dialógicos ocorreu a auto(trans)formação docente.

O processo de construção do Brasil, a partir do colonialismo, com a escravização dos povos africanos e indígenas, gerou inúmeras marcas de exclusão nestes grupos, assim como o próprio racismo e suas múltiplas formas de manifestações. Por isso, consideramos necessário investigar como o tema é compreendido nas mais diversas áreas, incluindo no Ensino de Ciências. Dessa maneira, neste estudo verificamos as percepções de docentes da área sobre as relações étnico-raciais e as implicações das Políticas Públicas no Ensino Superior a partir de discussões realizadas no episódio online acerca da ‘Racialidade, ensino e pesquisa’, do canal Educação em Ciências UFSM. A pesquisa é de natureza qualitativa e o método de análise utilizado foi a Análise Textual Discursiva. Do processo emergiram duas categorias: a) Inclusão e pertencimento: suas múltiplas interfaces; e, b) Enfrentamento ao racismo: implicações oriundas das desvantagens historicamente acumuladas. De modo geral, a partir da análise constatamos que a percepção dos docentes é favorável ao desenvolvimento das Políticas Públicas no Ensino Superior, pois concordam que contribuem para maior inclusão da população negra, assim como auxiliam no enfrentamento ao racismo e às desigualdades raciais.

O estesíoneuroblastoma (neuroblastoma olfatório) é um tumor raro do epitélio olfatório. Seu curso clínico habitual é caracterizado por crescimento lento e pela tendência a recidivar localmente. Neste relato é apresentado um caso de estesíoneuroblastoma em uma adolescente de 13 anos de idade, cujas características principais foram o sítio incomum de localização do tumor primário em nasofaringe, seu curso clínico rapidamente progressivo e dificuldade diagnostica. Nosso objetivo é chamar atenção para a existência desta neoplasia incomum e discutir seus aspectos mais relevantes, baseados em ampla revisão da literatura.

This study investigates the influence of geographical barriers and the challenges and advantages presented by information and communication technologies on digital governance within the judicial branch in the Brazilian Amazon region. The primary objective is to provide diagnoses and recommendations that can inform the construction of research for the development of policies aimed at enhancing access to judicial services by riverside populations. The methodology initially employed was a comprehensive literature review on digital governance within the judiciary and access to justice for vulnerable groups in a geographical context. Subsequently, a qualitative study was conducted, employing participant observation in the riverside communities of Itapéua and Boca do Una, situated along the Jaurucu River within the Porto de Moz District in the state of Pará. The insights garnered from respondent perceptions and participant observations were synthesized to formulate five key dimensions for digital governance and access to justice within Amazonian communities: (1) one’s experience with justice, (2) access to information, (3) geographical barriers, (4) user-friendliness of technology, and (5) resources and infrastructure supporting technology use. The study concludes that there are compelling indications that tailored digital governance and technology utilization by the judiciary, adapted to regional nuances, can significantly contribute to streamlining access to judicial services.