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1,372 results on '"Luberto A."'

103. Humanoids at Work: The WALK-MAN Robot in a Postearthquake Scenario.

Author

Francesca Negrello, Alessandro Settimi, Danilo Caporale, Gianluca Lentini, Mattia Poggiani, Dimitrios Kanoulas, Luca Muratore, Emanuele Luberto, Gaspare Santaera, Luca Ciarleglio, Leonardo Ermini, Lucia Pallottino, Darwin G. Caldwell, Nikolaos G. Tsagarakis, Antonio Bicchi, Manolo Garabini, and Manuel G. Catalano

Published
2018
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104. A Novel Lactobacillus brevis Fermented with a Vegetable Substrate (AL0035) Counteracts TNBS-Induced Colitis by Modulating the Gut Microbiota Composition and Intestinal Barrier.

Author

Vesci, Loredana, Tundo, Grazia, Soldi, Sara, Galletti, Serena, Stoppoloni, Daniela, Bernardini, Roberta, Modolea, Anamaria Bianca, Luberto, Laura, Marra, Emanuele, Giorgi, Fabrizio, and Marini, Stefano

Abstract

Crohn's and ulcerative colitis are common conditions associated with inflammatory bowel disease as well as intestinal flora and epithelial barrier dysfunction. A novel fermented Lactobacillus brevis (AL0035) herein assayed in a trinitro benzene sulfonic acid (TNBS)-induced colitis mice model after oral administration significantly counteracted the body weight loss and improves the disease activity index and histological injury scores. AL0035 significantly decreased the mRNA and protein expression of different pro-inflammatory cytokines (TNFalpha, IL-1beta, IL-6, IL-12, IFN-gamma) and enhanced the expression of IL-10. In addition, the probiotic promoted the expression of tight junction proteins, such as ZO-1, keeping the intestinal mucosal barrier function to attenuate colitis symptoms in mice. Markers of inflammation cascade such as myeloperoxidase (MPO) and PPAR-gamma measured in the colon were also modified by AL0035 treatment. AL0035 was also able to reduce different lymphocyte markers' infiltration in the colon (GATA-3, T-Bet, NK1.1) and monocyte chemoattractant protein-1 (MCP-1/CCL2), a key chemokine involved in the migration and infiltration of monocytes/macrophages in the immunological surveillance of tissues and inflammation. In colonic microbiota profile analysis through 16S rRNA sequencing, AL0035 increased the microbial diversity depleted by TNBS administration and the relative abundance of the Lactobacillaceae and Lachnospiraceae families, whereas it decreased the abundance of Proteobacteria. Altogether, these data indicated that AL0035 could lower the severity of colitis induced by TNBS by regulating inflammatory cytokines, increasing the expression of tight junction proteins and modulating intestinal microbiota, thus preventing tissue damage induced by colitis. [ABSTRACT FROM AUTHOR]

Published
2024
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105. Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein.

Author

D'Acunto, Emanuela, Muzi, Alessia, Marchese, Silvia, Donnici, Lorena, Chiarini, Valerio, Bucci, Federica, Pavoni, Emiliano, Ferrara, Fabiana Fosca, Cappelletti, Manuela, Arriga, Roberto, Serrao, Silvia Maria, Peluzzi, Valentina, Principato, Eugenia, Compagnone, Mirco, Pinto, Eleonora, Luberto, Laura, Stoppoloni, Daniela, Lahm, Armin, Groß, Rüdiger, and Seidel, Alina

Subjects
MONOCLONAL antibodies, SARS-CoV-2 Omicron variant, SARS-CoV-2, RECOMBINANT proteins, IMMUNOGLOBULINS, HUMORAL immunity
Abstract

The COVID-19 pandemic, once a global crisis, is now largely under control, a testament to the extraordinary global efforts involving vaccination and public health measures. However, the relentless evolution of SARS-CoV-2, leading to the emergence of new variants, continues to underscore the importance of remaining vigilant and adaptable. Monoclonal antibodies (mAbs) have stood out as a powerful and immediate therapeutic response to COVID-19. Despite the success of mAbs, the evolution of SARS-CoV-2 continues to pose challenges and the available antibodies are no longer effective. New variants require the ongoing development of effective antibodies. In the present study, we describe the generation and characterization of neutralizing mAbs against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein by combining plasmid DNA and recombinant protein vaccination. By integrating genetic immunization for rapid antibody production and the potent immune stimulation enabled by protein vaccination, we produced a rich pool of antibodies, each with unique binding and neutralizing specificities, tested with the ELISA, BLI and FACS assays and the pseudovirus assay, respectively. Here, we present a panel of mAbs effective against the SARS-CoV-2 variants up to Omicron BA.1 and BA.5, with the flexibility to target emerging variants. This approach ensures the preparedness principle is in place to address SARS-CoV-2 actual and future infections. [ABSTRACT FROM AUTHOR]

Published
2024
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106. Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S]

Author

Justin M. Snider, Ashley J. Snider, Lina M. Obeid, Chiara Luberto, and Yusuf A. Hannun

Subjects
flux, 17CdhSph, d17dhSph, 17 carbon dihydrosphingosine, Biochemistry, QD415-436
Abstract

Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), Sph 1-phosphate, and Cer 1-phosphate. The interconversion of these metabolites is controlled by a cohort of at least 40 enzymes, many of which respond to endogenous or exogenous stimuli. Typical probing of the sphingolipid pathway relies on sphingolipid mass levels or determination of the activity of individual enzymes. Either approach is unable to provide a complete analysis of flux through sphingolipid metabolism, which, given the interconnectivity of the sphingolipid pathway, is critical information to identify nodes of regulation. Here, we present a one-step in situ assay that comprehensively probes the flux through de novo sphingolipid synthesis, post serine palmitoyltransferase, by monitoring the incorporation and metabolism of the 17 carbon dihydrosphingosine precursor with LC/MS. Pulse labeling and analysis of precursor metabolism identified sequential well-defined phases of sphingolipid synthesis, corresponding to the activity of different enzymes in the pathway, further confirmed by the use of specific inhibitors and modulators of sphingolipid metabolism. This work establishes precursor pulse labeling as a practical tool for comprehensively studying metabolic flux through de novo sphingolipid synthesis and complex sphingolipid generation.

Published
2018
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107. Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality

Author

Snider, Justin M., You, Jeehyun Karen, Wang, Xia, Snider, Ashley J., Hallmark, Brian, Zec, Manja M., Seeds, Michael C., Sergeant, Susan, Johnstone, Laurel, Wang, Qiuming, Sprissler, Ryan, Carr, Tara F., Lutrick, Karen, Parthasarathy, Sairam, Bime, Christian, Zhang, Hao Helen, Luberto, Chiara, Kew, Richard R., Hannun, Yusuf A., Guerra, Stefano, McCall, Charles E., Yao, Guang, Del Poeta, Maurizio, and Chilton, Floyd H.

Subjects
Mitochondria -- Physiological aspects -- Health aspects, Phospholipases -- Physiological aspects -- Health aspects, Health care industry
Abstract

There is an urgent need to identify the cellular and molecular mechanisms responsible for severe COVID-19 that results in death. We initially performed both untargeted and targeted lipidomics as well as focused biochemical analyses of 127 plasma samples and found elevated metabolites associated with secreted phospholipase A2 ([sPLA.sub.2]) activity and mitochondrial dysfunction in patients with severe COVID-19. Deceased COVID-19 patients had higher levels of circulating, catalytically active [sPLA.sub.2] group IIA ([sPLA.sub.2]-IIA), with a median value that was 9.6-fold higher than that for patients with mild disease and 5.0-fold higher than the median value for survivors of severe COVID-19. Elevated [sPLA.sub.2]-IIA levels paralleled several indices of COVID-19 disease severity (e.g., kidney dysfunction, hypoxia, multiple organ dysfunction). A decision tree generated by machine learning identified [sPLA.sub.2]-IIA levels as a central node in the stratification of patients who died from COVID-19. Random forest analysis and least absolute shrinkage and selection operator-based (LASSO-based) regression analysis additionally identified [sPLA.sub.2]-IIA and blood urea nitrogen (BUN) as the key variables among 80 clinical indices in predicting COVID-19 mortality. The combined PLA-BUN index performed significantly better than did either one alone. An independent cohort (n = 154) confirmed higher plasma [sPLA.sub.2]-IIA levels in deceased patients compared with levels in plasma from patients with severe or mild COVID-19, with the PLA-BUN index-based decision tree satisfactorily stratifying patients with mild, severe, or fatal COVID-19. With clinically tested inhibitors available, this study identifies [sPLA.sub.2]-IIA as a therapeutic target to reduce COVID-19 mortality., Introduction Host resistance and disease tolerance are essential to mounting a successful defense against infections such as SARS-CoV-2. Up to 80% of individuals infected with SARS-CoV-2 are asymptomatic or develop [...]

Published
2021
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108. Sphingolipids in Hematopoiesis: Exploring Their Role in Lineage Commitment

Author

Yasharah Raza, Huda Salman, and Chiara Luberto

Subjects
sphingolipids, hematopoiesis, ceramide, sphingosine-1-phosphate, hematopoietic stem cells, erythrocytes, Cytology, QH573-671
Abstract

Sphingolipids, associated enzymes, and the sphingolipid pathway are implicated in complex, multifaceted roles impacting several cell functions, such as cellular homeostasis, apoptosis, cell differentiation, and more through intrinsic and autocrine/paracrine mechanisms. Given this broad range of functions, it comes as no surprise that a large body of evidence points to important functions of sphingolipids in hematopoiesis. As the understanding of the processes that regulate hematopoiesis and of the specific characteristics that define each type of hematopoietic cells is being continuously refined, the understanding of the roles of sphingolipid metabolism in hematopoietic lineage commitment is also evolving. Recent findings indicate that sphingolipid alterations can modulate lineage commitment from stem cells all the way to megakaryocytic, erythroid, myeloid, and lymphoid cells. For instance, recent evidence points to the ability of de novo sphingolipids to regulate the stemness of hematopoietic stem cells while a substantial body of literature implicates various sphingolipids in specialized terminal differentiation, such as thrombopoiesis. This review provides a comprehensive discussion focused on the mechanisms that link sphingolipids to the commitment of hematopoietic cells to the different lineages, also highlighting yet to be resolved questions.

Published
2021
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111. World Congress Integrative Medicine & Health 2017: Part one

Author

Benno Brinkhaus, Torkel Falkenberg, Aviad Haramati, Stefan N. Willich, Josephine P. Briggs, Merlin Willcox, Klaus Linde, Töres Theorell, Lisa M. Wong, Jeffrey Dusek, Darong Wu, David Eisenberg, Bettina Berger, Kathi Kemper, Beate Stock-Schröer, Hedda Sützl-Klein, Rosaria Ferreri, Gary Kaplan, Harald Matthes, Gabriele Rotter, Elad Schiff, Zahi Arnon, Eckhard Hahn, Christina M. Luberto, David Martin, Silke Schwarz, Diethard Tauschel, Andrew Flower, Harsha Gramminger, Hedwig H. Gupta, S. N. Gupta, Annette Kerckhoff, Christian S. Kessler, Andreas Michalsen, Eun S. Kim, Eun H. Jang, Rana Kim, Sae B. Jan, Martin Mittwede, Wiebke Mohme, Eran Ben-Arye, Massimo Bonucci, Bashar Saad, Thomas Breitkreuz, Elio Rossi, Rejin Kebudi, Michel Daher, Samaher Razaq, Nahla Gafer, Omar Nimri, Mohamed Hablas, Gunver Sophia Kienle, Noah Samuels, Michael Silbermann, Lena Bandelin, Anna-Lena Lang, Eva Wartner, Christoph Holtermann, Maxwell Binstock, Robert Riebau, Edin Mujkanovic, Holger Cramer, Romy Lauche, Andres Michalsen, Lesley Ward, Dominik Irnich, Wolfram Stör, Geoffrey Burnstock, Hans-Georg Schaible, Thomas Ots, Jost Langhorst, Tobias Sundberg, Catherina Amarell, Melanie Anheyer, Marion Eckert, Mercedes Ogal, Annette Schönauer, Birgit Reisenberger, Bernhard Brand, Dennis Anheyer, Gustav Dobos, Matthias Kroez, Aldo Ammendola, Jun J. Mao, Claudia Witt, Yufei Yang, Miriam Oritz, Markus Horneber, Petra Voiß, Alexandra von Rosenstiel, Catharina Amarell, Friedemann Schad, Marc Schläppi, Matthias Kröz, Arndt Büssing, Gil Bar-Sela, David Avshalomov, Samuel Attias, Sian Cotton, Miek Jong, Mats Jong, Christian Scheffer, Friedrich Edelhäuser, Abdullah AlBedah, Myeong Soo Lee, Mohamed Khalil, Keiko Ogawa, Yoshiharu Motoo, Junsuke Arimitsu, Masao Ogawa, Genki Shimizu, Rainer Stange, Karin Kraft, Kenny Kuchta, Kenji Watanabe, D Bonin, Harald Gruber, Sabine Koch, Urs Pohlmann, Christine Caldwell, Barbara Krantz, Ria Kortum, Lily Martin, Lisa S. Wieland, Ben Kligler, Susan Gould-Fogerite, Yuqing Zhang, John J. Riva, Michael Lumpkin, Emily Ratner, Liu Ping, Pei Jian, Gesa-Meyer Hamme, Xiaosong Mao, Han Chouping, Sven Schröder, Josef Hummelsberger, Michael Wullinger, Marc Brodzky, Christoff Zalpour, Julia Langley, Wendy Weber, Lanay M. Mudd, Peter Wayne, Clauda Witt, Wolfgang Weidenhammer, Vinjar Fønnebø, Heather Boon, Amie Steel, Andrea Bugarcic, Melisa Rangitakatu, Jon Adams, David Sibbritt, Jon Wardle, Matthew Leach, Janet Schloss, Helene Dieze, Nadine Ijaz, Michael Heinrich, George Lewith, Bertrand Graz, Daniela Adam, Linus Grabenhenrich, Miriam Ortiz, Sylvia Binting, Thomas Reinhold, Susanne Andermo, Johanna Hök Nordberg, Maria Arman, Manoj Bhasin, Xueyi Fan, Towia Libermann, Gregory Fricchione, John Denninger, Herbert Benson, David D. Martin, Inge Boers, Arine Vlieger, Michael Teut, Alexander Ullmann, Fabian Lotz, Stephanie Roll, Claudia Canella, Michael Mikolasek, Matthias Rostock, Jörg Beyer, Matthias Guckenberger, Josef Jenewein, Esther Linka, Claudia Six, Sarah Stoll, Roger Stupp, Claudia M. Witt, Elisabeth Chuang, Melissa D. McKee, Petra Klose, Silke Lange, Vincent C. H. Chung, Hoi L. C. Wong, Xin Y. Wu, Grace Y. G. Wen, Robin S. T. Ho, Jessica Y. L. Ching, Justin C. Y. Wu, Amanda Coakley, Jane Flanagan, Christine Annese, Joanne Empoliti, Zishan Gao, Xugang Liu, Shuguang Yu, Xianzhong Yan, Fanrong Liang, Christoph D. Hohmann, Nico Steckhan, Thomas Ostermann, Arion Paetow, Evelyn Hoff, Xiao-Yang Hu, Ruo-Han Wu, Martin Logue, Clara Blonde, Lily Y. Lai, Beth Stuart, Yu-Tong Fei, Michael Moore, Jian-Ping Liu, Michael Jeitler, Hannah Zillgen, Manuel Högl, Barbara Stöckigt, Georg Seifert, Christian Kessler, Talat Khadivzadeh, Maryam Hassanzadeh Bashtian, Shapour Badiee Aval, Habibollah Esmaily, Jihye Kim, Keun H. Kim, Carina Klocke, Stefanie Joos, Abdulrahman Koshak, Li Wie, Emad Koshak, Siraj Wali, Omer Alamoudi, Abdulrahman Demerdash, Majdy Qutub, Peter Pushparaj, Sigrid Kruse, Isabell Fischer, Nadine Tremel, Joseph Rosenecker, Brenda Leung, Wendy Takeda, Ning Liang, Xue Feng, Jian-ping Liu, Hui-juan Cao, Nina Shinday, Lisa Philpotts, Elyse Park, Gregory L. Fricchione, Gloria Yeh, Niki Munk, Arash Zakeresfahani, Trevor R. Foote, Rick Ralston, Karen Boulanger, Dominik Özbe, Elmar Gräßel, Katharina Luttenberger, Anna Pendergrass, Daniel Pach, Judit Bellmann-Strobl, Yinhui Chang, Laura Pasura, Bin Liu, Sven F. Jäger, Ronny Loerch, Li Jin, Katja Icke, Xuemin Shi, Friedemann Paul, Michaela Rütz, Andreas Lynen, Meike Schömitz, Maik Vahle, Nir Salomon, Alon Lang, Adi Lahat, Uri Kopylov, Shomron Ben-Horin, Ofir Har-Noi, Benjamin Avidan, Rami Elyakim, Dorit Gamus, Siew NG, Jessica Chang, Justin Wu, John Kaimiklotis, Dania Schumann, Ludovica Buttó, Dirk Haller, Caroline Smith, Sheryl de Lacey, Michael Chapman, Julie Ratcliffe, Neil Johnson, Jane Lyttleton, Clare Boothroyd, Paul Fahey, Bram Tjaden, Marja van Vliet, Herman van Wietmarschen, Wilfried Tröger, Pia Vuolanto, Paulina Aarva, Minna Sorsa, Kaija Helin, Claudia Wenzel, Iris Zoderer, Patricia Pammer, Patrick Simon, Gerhard Tucek, Kathrin Wode, Roger Henriksson, Lena Sharp, Anna Stoltenberg, Yang Xiao-ying, Li-qiong Wang, Jin-gen Li, Ying Wang, Lynda Balneaves, Rielle Capler, Chiara Bocci, Marta Guffi, Marina Paolini, Ilaria Meaglia, Patrizia Porcu, Giovanni B. Ivaldi, Simona Dragan, Petru Bucuras, Ana M. Pah, Marius Badalica-Petrescu, Florina Buleu, Gheorghe Hogea-Stoichescu, Ruxandra Christodorescu, Lan Kao, Yumin Cho, Nadja Klafke, Cornelia Mahler, Cornelia von Hagens, Lorenz Uhlmann, Martina Bentner, Andreas Schneeweiss, Andreas Mueller, Joachim Szecsenyi, Isabella Neri, Katharina Schnabel, Margit Cree, Ralf Suhr, Sonia Baccetti, Fabio Firenzuoli, Maria V. Monechi, Mariella Di Stefano, Gianni Amunni, Wendy Wong, Bingzhong Chen, Hakima Amri, Lucy Kotlyanskaya, Belinda Anderson, Roni Evans, Paul Marantz, Ryan Bradley, Cathryn Booth-LaForce, Heather Zwickey, Benjamin Kligler, Audrey Brooks, Mary J. Kreitzer, Patricia Lebensohn, Elisabeth Goldblatt, Neus Esmel-Esmel, Maria Jiménez-Herrera, Alexandra Jocham, Pascal O. Berberat, Antonius Schneider, Morgana Masetti, Henriette Murakozy, Marja Van Vliet, Rita Agdal, Fatemeh Atarzadeh, Amir M. Jaladat, Leila Hoseini, Fatemeh Amini, Chen Bai, Tiegang Liu, Zian Zheng, Yuxiang Wan, Jingnan Xu, Xuan Wang, He Yu, Xiaohong Gu, Babak Daneshfard, Majid Nimrouzi, Vahid Tafazoli, Seyed M. Emami Alorizi, Seyed A. Saghebi, Mohammad R. Fattahi, Alireza Salehi, Hossein Rezaeizadeh, Mohammad M. Zarshenas, Kealoha Fox, John Hughes, Nenad Kostanjsek, Stéphane Espinosa, Peter Fisher, Abdul Latif, Donald Lefeber, William Paske, Ali Ö. Öztürk, Gizemnur Öztürk, Wim Tissing, Marianne Naafs, Martine Busch, Mohammad R. Sanaye, Kilian Dräger, Brent Leininger, Kate Shafto, Jenny Breen, Ana P. Simões-Wüst, Carolina Moltó-Puigmartí, Martien van Dongen, Pieter Dagnelie, Carel Thijs, Shelley White, Solveig Wiesener, Anita Salamonsen, Trine Stub, Sergio Abanades, Mar Blanco, Laia Masllorens, Roser Sala, Shafekah Al-Ahnoumy, Dongwoon Han, Luzhu He, Ha Yun Kim, Da In Choi, Terje Alræk, Agnete Kristoffersen, Christel von Sceidt, Stig Bruset, Frauke Musial, Felix J. Saha, Heidemarie Haller, Hoda Azizi, Nayereh Khadem, Malihe Hassanzadeh, Nazanin Estiri, Hamideh Azizi, Fatemeh Tavassoli, Marzieh Lotfalizadeh, Reza Zabihi, Mahmoud Mohammadzadeh Shabestari, Reza Paeizi, Masoumeh Alvandi Azari, Hamidreza Bahrami-Taghanaki, Erik Baars, Anja De Bruin, Anne Ponstein, Sergio Segantini, Maria Valeria Monechi, Fabio Voller, Jürgen Barth, Alexandra Kern, Sebastian Lüthi, Anja Zieger, Fabius Otto, Ariel Beccia, Corina Dunlap, Brendan Courneene, Paula Bedregal, Alvaro Passi, Alfredo Rodríguez, Mayling Chang, Soledad Gutiérrez, Florian Beissner, Christine Preibisch, Annemarie Schweizer-Arau, Roxana Popovici, Karin Meissner, Sylvie Beljanski, Laura Belland, Laura Rivera-Reyes, Ula Hwang, Dominik Sethe, Dörte Hilgard, Peter Heusser, Felicity Bishop, Miznah Al-Abbadey, Katherine Bradbury, Dawn Carnes, Borislav Dimitrov, Carol Fawkes, Jo Foster, Hugh MacPherson, Lisa Roberts, Lucy Yardley, Michelle Holmes, Paul Little, Cyrus Cooper, Patrizia Bogani, Valentina Maggini, Eugenia Gallo, Elisangela Miceli, Sauro Biffi, Alessio Mengoni, Renato Fani, Nadine Brands-Guendling, Peter W. Guendling, Gert Bronfort, Mitch Haas, Craig Schulz, Xiangwei Bu, J. Wang, T. Fang, Z. Shen, Y. He, X. Zhang, Zhengju Zhang, Dali Wang, Fengxian Meng, Klaus Baumann, Eckhard Frick, Christoph Jacobs, Ralph-Achim Grünther, Désirée Lötzke, Sonny Jung, Daniela R. Recchia, Sibylle Robens, Josephin Stankewitz, Mika Jeitler, Chunhoo Cheon, Bo H. Jang, Seong G. Ko, Ching W. Huang, Yui Sasaki, Youme Ko, Anna Cheshire, Damien Ridge, David Peters, Maria Panagioti, Chantal Simon, Hyun J. Cho, Soo J. Choi, Young S. Jung, Hyea B Im, Kieran Cooley, Laura Tummon-Simmons, Rachel Wasson, Kristen Kraemer, Richard Sears, Carly Hueber, Gwendolyn Derk, JR Lill, Ruopeng An, Lois Steinberg, Lourdes Diaz Rodriguez, Francisca García-de la Fuente, Miguel De la Vega, Keyla Vargas-Román, Jonatan Fernández-Ruiz, Irene Cantarero-Villanueva, Francisca García-De la Fuente, Fanny Jiménez-Guerrero, Noelia Galiano-Castillo, Gualberto Diaz-Saez, José I. Torres-Jimenez, Olga Garcia-Gomez, Luis Hortal-Muñoz, Camino Diaz-Diez, Demijon Dicen, Helene Diezel, Jane Frawley, Alex Broom, Fei Dong, Xueyan Ma, Liyi Yan, Liqun Wu, Jiaju Ma, Jianhua Zhen, Julie Dubois, Pierre-Yves Rodondi, Sophia Schwartze, Barbara Trapp, and Dirk Cysarz

Subjects
Other systems of medicine, RZ201-999
Published
2017
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122. Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

Author

Rottoli, Matteo, Gori, Alice, Pellino, Gianluca, Flacco, Maria Elena, Martellucci, Cecilia, Spinelli, Antonino, Poggioli, Gilberto, Romano, Angela, Belvedere, Angela, Lanci Lanci, Antonio, Parlanti, Daniele, Vago, Gabriele, Pezzuto, Paola, Canavese, Anna, Dajti, Gerti, Cardelli, Stefano, Catalioto, Caterina, Russo, Iris S, Violante, Tommaso, Morezzi, Daniele, Maurino, Ludovica, Filippone, Eleonora, Cuicchi, Dajana, Bernante, Paolo, Jovine, Elio, Lombardi, Raffaele, Masetti, Michele, Cipressi, Chiara, Offi, Maria F, Larotonda, Cristina, Puglisi, Silvana B, Barbosa, Augusto, Vaiana, Roberto, Bianchi, Paolo M, Tonti, Carlo, Codignola, Claudio, Zorcolo, Luigi, Restivo, Angelo, Deidda, Simona, Marchetti, Marcello E, Ippolito, Luca, Spolverato, Gaya, Pucciarelli, Salvatore, Marchegiani, Francesco, Ghio, Giacomo, Zagolin, Gaya, Glavas, Dajana, Tomassi, Monica, Rosati, Riccardo, Elmore, Ugo, Gozzini, Lorenzo, Calef, Riccardo, Puccetti, Francesco, Cossu, Andrea, Vignali, Andrea, Morino, Mario, Allaix, Marco E, Cannata, Gaspare, Lombardi, Erica, Ammirati, Carlo A, Piceni, Chiara, Buccianti, Piero, Balestri, Riccardo, Puccini, Marco, Pezzati, Daniele, d'Ischia, Roberto, Asta, Vito F, Sargenti, Benedetta, Taddei, Giacomo, Bonari, Federica, Boni, Giulia, Ferrero, Alessandro, Mineccia, Michela, Gonella, Federica, Palisi, Marco, Danese, Francesco, Cherubini, Valeria, Perotti, Serena, Carvello, Michele, Carbone, Fabio, Luberto, Antonio, Calafiore, Eleonora, De Lucia, Francesca, Sacchi, Matteo, Sasia, Diego, Giuffrida, Maria C, Ballauri, Edoardo, Cardile, Mathieu, Armentano, Serena, Beltrami, Elsa, Preve, Gabriele, Vercellone, Barbara, Mozzon, Marta, Folliero, Cristina, Lirusso, Chiara, Vecchiato, Massimo, Ziccarelli, Antonio, Gattesco, Davide, Moretti, Luisa, Crestale, Sara, Banchini, Filippo, Capelli, Patrizio, Romboli, Andrea, Palmieri, Gerardo, Conti, Luigi, Rizzi, Nicholas, Bonfili, Deborah, de Manzini, Nicolò, Germani, Paola, Osenda, Edoardo, Cortinovis, Sara, Giunta, Carlotta, Fracon, Stefano, Abdallah, Hussein, Bogoni, Selene, Portolani, Nazario, Nascimbeni, Riccardo, Molfino, Sarah, Tiberio, Guido A M, Garosio, Ilenia, Lamperti, Giulia, Rigosa, Diego, Ercolani, Giorgio, Solaini, Leonardo, Cavaliere, Davide, Avanzolini, Andrea, D'Acapito, Fabrizio, Chiarella, Leonardo L, Di Pietrantonio, Daniela, Annunziata, Domenico, Piccolo, Roberta, Sorrentino, Mario, Pansini, Mauro, Cojutti, Alessandro, Graziano, Michele, Callegari, Francesco, Balzarotti, Laura, Dameno, Vitale R, Cattaneo, Antonio, Santolamazza, Giuliano, Altieri, Caterina, Magarini, Riccardo, Pietrabissa, Andrea, Dominioni, Tommaso, Pugliese, Luigi, Peri, Andrea, Botti, Marta, Salvetti, Francesco, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Messina, Valentina, D'Abrosca, Vera, Cianci, Pasquale, Tumolo, Rocco, Gattulli, Domenico, Restini, Enrico, Minafra, Marina, Sederino, Maria G, Bottalico, Bernardino, Pilati, Pierluigi, Franzato, Boris, Mattara, Genny, De Simoni, Ottavia, Barina, Andrea, Tonello, Marco, Muratore, Andrea, Calabrò, Marcello, Federico Pipitone, Nicoletta S, Cuzzola, Bruno, Herranz van Nood, Elena, Passuello, Nicola, Frasson, Alvise, Mammano, Enzo, Faccio, Luca, Vittadello, Fabrizio, Bressan, Alice, Sarzo, Giacomo, Tamini, Nicolò, Oldani, Massimo, Cigagna, Luca, Carissimi, Francesca, De Carlo, Giulia, Baccalini, Edoardo, Nespoli, Luca, Giordano, Alessio, Cantafio, Stefano, Grifoni, Lucrezia, Matani, Davide, Livi, Serena, Delogu, Daniele, Scognamillo, Fabrizio, Marrosu, Antonio, Guerrini, Luca, Ugolini, Giampaolo, Ghignone, Federico, Frascaroli, Giacomo, Albertini, Nicola, Zattoni, Davide, Taffurelli, Giovanni, Montroni, Isacco, Colombo, Francesco, Danelli, Piergiorgio, Bondurri, Andrea, Maffioli, Anna, Bonomi, Alessandro, Pezzoli, Isabella, Cammarata, Francesco, Goletti, Orlando, Molteni, Mattia, Assisi, Alberto, Quartierini, Giorgio, Da Lio, Corrado, Verdi, Daunia, Mondi, Isabella, Peluso, Claudia, Macchi, Lorenzo, Tanzanu, Marta, Zanzi, Federico, Pellegrini, Sara, Andreuccetti, Jacopo, D'Alessio, Rossella, Pignata, Giusto, De Capua, Michele, Canfora, Ilaria, Ottaviani, Luca, Lepiane, Pasquale, Balla, Andrea, De Carlo, Antonio, Saraceno, Federica, Scaramuzzo, Rosa, Guida, Anna, Aguzzi, Daniele, Bellora, Paolo, Gentilli, Sergio, Monni, Manuela, Nikaj, Herald, Cillara, Nicola, Cannavera, Alessandro, Deserra, Antonello, Margiani, Carla, Cabula, Roberta, Dettori, Manuela, Gramignano, Giulia, Lezoche, Giovanni, Ortenzi, Monica, Orlandoni, Elena S, Curzi, Federica, Vitali, Francesca, Capomagi, Perla, Palmieri, Miriam, Giuffrida, Mario, Del Rio, Paolo, Bonati, Elena, Loderer, Tommaso, Cozzani, Federico, Rossini, Matteo, Agnesi, Stefano, Capolupo, Gabriella T, Caricato, Marco, Carannante, Filippo, Mascianà, Gianluca, Marrelli, Martina, Miacci, Valentina, Lauricella, Sara, Tonini, Valeria, Cervellera, Maurizio, Pisconti, Salvatore, Lozito, Concetta, Shahu, Juliana, Mongelli, Claudia, Morelli, Giulia, Sartarelli, Lodovico, Sica, Giuseppe S, Siragusa, Leandro, Bagaglini, Giulia, Sensi, Bruno, Guida, Andrea M, Franceschilli, Marzia, Vinci, Danilo, Taddei, Antonio, Risaliti, Matteo, Bartolini, Ilenia, Ringressi, Maria N, Tirloni, Luca, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Gobbi, Pietro, Opocher, Enrico, Mariani, Nicolò M, Pisani Ceretti, Andrea, Giovenzana, Marco, Giuliani, Beatrice, Sironi, Martina, Grossi, Ugo, Zanus, Giacomo, Aniello Santoro, Giulio, Brizzolari, Marco, De Leo, Eugenio, Novello, Simone, Aquilino, Krizia, Milardi, Francesco, Olmi, Stefano, Uccelli, Matteo, Bonaldi, Marta, Cesana, Giovanni C, Bindi, Marco, Galleano, Raffaele, Langone, Antonio, Botto, Massimiliano, Franceschi, Angelo, Gambino, Elena, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Ciulla, Salvatore L, Terrosu, Giovanni, Calandra, Sergio, Scarpa, Edoardo, Cherchi, Vittorio, Calini, Giacomo, Martinuzzo, Lisa, Clocchiatti, Lucrezia, Muschitiello, Davide, Romanzi, Andrea, Vignati, Barbara, Vannelli, Alberto, Scolaro, Roberta, Milanesi, Maria, Rossi, Fabrizio, Canonico, Giuseppe, Anastasi, Alessandro, Nelli, Tommaso, Barlettai, Marco, Fratarcangeli, Riccardo, Di Martino, Carmela, Damigella, Andrea, Adinolfi, Elvira, Birindelli, Arianna, Taglietti, Lucio, Dester, Sara E, Fleres, Francesco, Cucinotta, Eugenio, Viscosi, Francesca, Biondo Santino, Antonio, Badessi, Giorgio, Catarsini, Nivia, Mazzeo, Carmelo, Rega, Daniela, Delrio, Paolo, Cervone, Carmela, Aversano, Alessia, De Franciscis, Silvia, Di Marzo, Massimiliano, Marra, Bruno, Pace, Ugo, Amato, Antonio, Batistotti, Paola, Mina, Elisa, Serventi, Alberto, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Brachini, Gioia, Cirillo, Bruno, Fiori, Enrico, Crocetti, Daniele, Clementi, Ilaria, Martines, Gennaro, Picciariello, Arcangelo, Tomasicchio, Giovanni, Dibra, Rigers, Trigiante, Giuseppe, Rinaldi, Marcella, Lantone, Giuliano, Porcu, Alberto, Perra, Teresa, Scanu, Antonio M, Feo, Claudio F, Fancellu, Alessandro, Cossu, Maria L, Ginesu, Giorgio C, Patriti, Alberto, Coletta, Diego, Petrelli, Filippo, Greco, Paola A, Spadoni, Claudia, Cassiani, Giovanna, Bianchini, Federica, Arganini, Marco, Bianchini, Matteo, Perotti, Bruno, Palmeri, Matteo, Scabini, Stefano, Deiana, Selene, Carganico, Giacomo, Pertile, Davide, Soriero, Domenico, Fioravanti, Emanuela, Sperotto, Beatrice, Nardo, Bruno, Paglione, Daniele, Crocco, Veronica, Doni, Marco, Osso, Mariasara, Perri, Roberto, Sampietro, Gianluca M, Corbellini, Carlo, Lorusso, Leonardo, Manzo, Carlo A, Cigognini, Maria, Baldi, Caterina, Palomba, Giuseppe, Aprea, Giovanni, Capuano, Marianna, Basile, Raffaele, Tutino, Roberta, Massani, Marco, Marinelli, Laura, Canitano, Nicola, Pilia, Tiziana, Podda, Mauro, Pisanu, Adolfo, Murzi, Valentina, Incani, Silvia, Frongia, Federica, Esposito, Giuseppe, Luglio, Gaetano, Tropeano, Francesca P, Pagano, Gianluca, Spina, Eduardo, De Simone, Giuseppe, Cricrì, Michele, Catena, Fausto, Vallicelli, Carlo, Zanini, Nicola, Ronconi, Diana, Favi, Francesco, Mazzucchelli, Carlo, Convertini, Girolamo, Vincenti, Leonardo, Andriola, Valeria, Bizzoca, Cinzia, Feo, Carlo V, Fabbri, Nicolò, Fazzin, Marta, Pesce, Antonio, Gennari, Silvia, Torchiaro, Marco, Severi, Silvia, Frontali, Alice, Bracchetti, Greta, Granieri, Stefano, Cotsoglou, Christian, Carlini, Massimo, Lisi, Giorgio, Spoletini, Domenico, Mastrangeli, Maria R, Campanelli, Michela, Manigrasso, Michele, Milone, Marco, De Palma, Giovanni D, Vertaldi, Sara, Chini, Alessia, Maione, Francesco, Marello, Alessandra, Selvaggi, Francesco, Sciaudone, Guido, Selvaggi, Lucio, Menegon Tasselli, Francesco, Fuschillo, Giacomo, Oddis, Lidia, Grande, Simona, Grande, Michele, Ascanelli, Simona, Chimisso, Laura, Aisoni, Filippo, Rossin, Eleonora, Pepe, Francesco, Marchetti, Francesco, Picardi, Biagio, Rossi, Stefano, Rossi Del Monte, Simone, Picarelli, Matteo, Muttillo, Irnerio A, Ratto, Carlo, Marra, Angelo A, Parello, Angelo, Litta, Francesco, Campennì, Paola, De Simone, Veronica, Pata, Francesco, Riboni, Cristiana, Rausa, Emanuele, Celentano, Valerio, Institut Català de la Salut, [Rottoli M, Gori A, Pellino G] Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy. Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy. [Pellino G] Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Flacco ME, Martellucci C] Department of Environmental and Preventive Sciences, University of Ferrara, Ferrara, Italy. [Spinelli A] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. Colorectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy, Vall d'Hebron Barcelona Hospital Campus, Rottoli, Matteo, Gori, Alice, Pellino, Gianluca, Flacco, Maria Elena, Martellucci, Cecilia, Spinelli, Antonino, Poggioli, Gilberto, Romano, Angela, Belvedere, Angela, Lanci Lanci, Antonio, Parlanti, Daniele, Vago, Gabriele, Pezzuto, Paola, Canavese, Anna, Dajti, Gerti, Cardelli, Stefano, Catalioto, Caterina, Russo, Iris S, Violante, Tommaso, Morezzi, Daniele, Maurino, Ludovica, Filippone, Eleonora, Cuicchi, Dajana, Bernante, Paolo, Jovine, Elio, Lombardi, Raffaele, Masetti, Michele, Cipressi, Chiara, Offi, Maria F, Larotonda, Cristina, Puglisi, Silvana B, Barbosa, Augusto, Vaiana, Roberto, Bianchi, Paolo M, Tonti, Carlo, Codignola, Claudio, Zorcolo, Luigi, Restivo, Angelo, Deidda, Simona, Marchetti, Marcello E, Ippolito, Luca, Spolverato, Gaya, Pucciarelli, Salvatore, Marchegiani, Francesco, Ghio, Giacomo, Zagolin, Gaya, Glavas, Dajana, Tomassi, Monica, Rosati, Riccardo, Elmore, Ugo, Gozzini, Lorenzo, Calef, Riccardo, Puccetti, Francesco, Cossu, Andrea, Vignali, Andrea, Morino, Mario, Allaix, Marco E, Cannata, Gaspare, Lombardi, Erica, Ammirati, Carlo A, Piceni, Chiara, Buccianti, Piero, Balestri, Riccardo, Puccini, Marco, Pezzati, Daniele, d'Ischia, Roberto, Asta, Vito F, Sargenti, Benedetta, Taddei, Giacomo, Bonari, Federica, Boni, Giulia, Ferrero, Alessandro, Mineccia, Michela, Gonella, Federica, Palisi, Marco, Danese, Francesco, Cherubini, Valeria, Perotti, Serena, Carvello, Michele, Carbone, Fabio, Luberto, Antonio, Calafiore, Eleonora, De Lucia, Francesca, Sacchi, Matteo, Sasia, Diego, Giuffrida, Maria C, Ballauri, Edoardo, Cardile, Mathieu, Armentano, Serena, Beltrami, Elsa, Preve, Gabriele, Vercellone, Barbara, Mozzon, Marta, Folliero, Cristina, Lirusso, Chiara, Vecchiato, Massimo, Ziccarelli, Antonio, Gattesco, Davide, Moretti, Luisa, Crestale, Sara, Banchini, Filippo, Capelli, Patrizio, Romboli, Andrea, Palmieri, Gerardo, Conti, Luigi, Rizzi, Nichola, Bonfili, Deborah, de Manzini, Nicolò, Germani, Paola, Osenda, Edoardo, Cortinovis, Sara, Giunta, Carlotta, Fracon, Stefano, Abdallah, Hussein, Bogoni, Selene, Portolani, Nazario, Nascimbeni, Riccardo, Molfino, Sarah, Tiberio, Guido A M, Garosio, Ilenia, Lamperti, Giulia, Rigosa, Diego, Ercolani, Giorgio, Solaini, Leonardo, Cavaliere, Davide, Avanzolini, Andrea, D'Acapito, Fabrizio, Chiarella, Leonardo L, Di Pietrantonio, Daniela, Annunziata, Domenico, Piccolo, Roberta, Sorrentino, Mario, Pansini, Mauro, Cojutti, Alessandro, Graziano, Michele, Callegari, Francesco, Balzarotti, Laura, Dameno, Vitale R, Cattaneo, Antonio, Santolamazza, Giuliano, Altieri, Caterina, Magarini, Riccardo, Pietrabissa, Andrea, Dominioni, Tommaso, Pugliese, Luigi, Peri, Andrea, Botti, Marta, Salvetti, Francesco, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Messina, Valentina, D'Abrosca, Vera, Cianci, Pasquale, Tumolo, Rocco, Gattulli, Domenico, Restini, Enrico, Minafra, Marina, Sederino, Maria G, Bottalico, Bernardino, Pilati, Pierluigi, Franzato, Bori, Mattara, Genny, De Simoni, Ottavia, Barina, Andrea, Tonello, Marco, Muratore, Andrea, Calabrò, Marcello, Federico Pipitone, Nicoletta S, Cuzzola, Bruno, Herranz van Nood, Elena, Passuello, Nicola, Frasson, Alvise, Mammano, Enzo, Faccio, Luca, Vittadello, Fabrizio, Bressan, Alice, Sarzo, Giacomo, Tamini, Nicolò, Oldani, Massimo, Cigagna, Luca, Carissimi, Francesca, De Carlo, Giulia, Baccalini, Edoardo, Nespoli, Luca, Giordano, Alessio, Cantafio, Stefano, Grifoni, Lucrezia, Matani, Davide, Livi, Serena, Delogu, Daniele, Scognamillo, Fabrizio, Marrosu, Antonio, Guerrini, Luca, Ugolini, Giampaolo, Ghignone, Federico, Frascaroli, Giacomo, Albertini, Nicola, Zattoni, Davide, Taffurelli, Giovanni, Montroni, Isacco, Colombo, Francesco, Danelli, Piergiorgio, Bondurri, Andrea, Maffioli, Anna, Bonomi, Alessandro, Pezzoli, Isabella, Cammarata, Francesco, Goletti, Orlando, Molteni, Mattia, Assisi, Alberto, Quartierini, Giorgio, Da Lio, Corrado, Verdi, Daunia, Mondi, Isabella, Peluso, Claudia, Macchi, Lorenzo, Tanzanu, Marta, Zanzi, Federico, Pellegrini, Sara, Andreuccetti, Jacopo, D'Alessio, Rossella, Pignata, Giusto, De Capua, Michele, Canfora, Ilaria, Ottaviani, Luca, Lepiane, Pasquale, Balla, Andrea, De Carlo, Antonio, Saraceno, Federica, Scaramuzzo, Rosa, Guida, Anna, Aguzzi, Daniele, Bellora, Paolo, Gentilli, Sergio, Monni, Manuela, Nikaj, Herald, Cillara, Nicola, Cannavera, Alessandro, Deserra, Antonello, Margiani, Carla, Cabula, Roberta, Dettori, Manuela, Gramignano, Giulia, Lezoche, Giovanni, Ortenzi, Monica, Orlandoni, Elena S, Curzi, Federica, Vitali, Francesca, Capomagi, Perla, Palmieri, Miriam, Giuffrida, Mario, Del Rio, Paolo, Bonati, Elena, Loderer, Tommaso, Cozzani, Federico, Rossini, Matteo, Agnesi, Stefano, Capolupo, Gabriella T, Caricato, Marco, Carannante, Filippo, Mascianà, Gianluca, Marrelli, Martina, Miacci, Valentina, Lauricella, Sara, Tonini, Valeria, Cervellera, Maurizio, Pisconti, Salvatore, Lozito, Concetta, Shahu, Juliana, Mongelli, Claudia, Morelli, Giulia, Sartarelli, Lodovico, Sica, Giuseppe S, Siragusa, Leandro, Bagaglini, Giulia, Sensi, Bruno, Guida, Andrea M, Franceschilli, Marzia, Vinci, Danilo, Taddei, Antonio, Risaliti, Matteo, Bartolini, Ilenia, Ringressi, Maria N, Tirloni, Luca, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Gobbi, Pietro, Opocher, Enrico, Mariani, Nicolò M, Pisani Ceretti, Andrea, Giovenzana, Marco, Giuliani, Beatrice, Sironi, Martina, Grossi, Ugo, Zanus, Giacomo, Aniello Santoro, Giulio, Brizzolari, Marco, De Leo, Eugenio, Novello, Simone, Aquilino, Krizia, Milardi, Francesco, Olmi, Stefano, Uccelli, Matteo, Bonaldi, Marta, Cesana, Giovanni C, Bindi, Marco, Galleano, Raffaele, Langone, Antonio, Botto, Massimiliano, Franceschi, Angelo, Gambino, Elena, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Ciulla, Salvatore L, Terrosu, Giovanni, Calandra, Sergio, Scarpa, Edoardo, Cherchi, Vittorio, Calini, Giacomo, Martinuzzo, Lisa, Clocchiatti, Lucrezia, Muschitiello, Davide, Romanzi, Andrea, Vignati, Barbara, Vannelli, Alberto, Scolaro, Roberta, Milanesi, Maria, Rossi, Fabrizio, Canonico, Giuseppe, Anastasi, Alessandro, Nelli, Tommaso, Barlettai, Marco, Fratarcangeli, Riccardo, Di Martino, Carmela, Damigella, Andrea, Adinolfi, Elvira, Birindelli, Arianna, Taglietti, Lucio, Dester, Sara E, Fleres, Francesco, Cucinotta, Eugenio, Viscosi, Francesca, Biondo Santino, Antonio, Badessi, Giorgio, Catarsini, Nivia, Mazzeo, Carmelo, Rega, Daniela, Delrio, Paolo, Cervone, Carmela, Aversano, Alessia, De Franciscis, Silvia, Di Marzo, Massimiliano, Marra, Bruno, Pace, Ugo, Amato, Antonio, Batistotti, Paola, Mina, Elisa, Serventi, Alberto, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Brachini, Gioia, Cirillo, Bruno, Fiori, Enrico, Crocetti, Daniele, Clementi, Ilaria, Martines, Gennaro, Picciariello, Arcangelo, Tomasicchio, Giovanni, Dibra, Riger, Trigiante, Giuseppe, Rinaldi, Marcella, Lantone, Giuliano, Porcu, Alberto, Perra, Teresa, Scanu, Antonio M, Feo, Claudio F, Fancellu, Alessandro, Cossu, Maria L, Ginesu, Giorgio C, Patriti, Alberto, Coletta, Diego, Petrelli, Filippo, Greco, Paola A, Spadoni, Claudia, Cassiani, Giovanna, Bianchini, Federica, Arganini, Marco, Bianchini, Matteo, Perotti, Bruno, Palmeri, Matteo, Scabini, Stefano, Deiana, Selene, Carganico, Giacomo, Pertile, Davide, Soriero, Domenico, Fioravanti, Emanuela, Sperotto, Beatrice, Nardo, Bruno, Paglione, Daniele, Crocco, Veronica, Doni, Marco, Osso, Mariasara, Perri, Roberto, Sampietro, Gianluca M, Corbellini, Carlo, Lorusso, Leonardo, Manzo, Carlo A, Cigognini, Maria, Baldi, Caterina, Palomba, Giuseppe, Aprea, Giovanni, Capuano, Marianna, Basile, Raffaele, Tutino, Roberta, Massani, Marco, Marinelli, Laura, Canitano, Nicola, Pilia, Tiziana, Podda, Mauro, Pisanu, Adolfo, Murzi, Valentina, Incani, Silvia, Frongia, Federica, Esposito, Giuseppe, Luglio, Gaetano, Tropeano, Francesca P, Pagano, Gianluca, Spina, Eduardo, De Simone, Giuseppe, Cricrì, Michele, Catena, Fausto, Vallicelli, Carlo, Zanini, Nicola, Ronconi, Diana, Favi, Francesco, Mazzucchelli, Carlo, Convertini, Girolamo, Vincenti, Leonardo, Andriola, Valeria, Bizzoca, Cinzia, Feo, Carlo V, Fabbri, Nicolò, Fazzin, Marta, Pesce, Antonio, Gennari, Silvia, Torchiaro, Marco, Severi, Silvia, Frontali, Alice, Bracchetti, Greta, Granieri, Stefano, Cotsoglou, Christian, Carlini, Massimo, Lisi, Giorgio, Spoletini, Domenico, Mastrangeli, Maria R, Campanelli, Michela, Manigrasso, Michele, Milone, Marco, De Palma, Giovanni D, Vertaldi, Sara, Chini, Alessia, Maione, Francesco, Marello, Alessandra, Selvaggi, Francesco, Sciaudone, Guido, Selvaggi, Lucio, Menegon Tasselli, Francesco, Fuschillo, Giacomo, Oddis, Lidia, Grande, Simona, Grande, Michele, Ascanelli, Simona, Chimisso, Laura, Aisoni, Filippo, Rossin, Eleonora, Pepe, Francesco, Marchetti, Francesco, Picardi, Biagio, Rossi, Stefano, Rossi Del Monte, Simone, Picarelli, Matteo, Muttillo, Irnerio A, Ratto, Carlo, Marra, Angelo A, Parello, Angelo, Litta, Francesco, Campennì, Paola, De Simone, Veronica, Pata, Francesco, Riboni, Cristiana, Rausa, Emanuele, and Celentano, Valerio

Subjects
Adult, Male, Settore MED/18 - CHIRURGIA GENERALE, Otros calificadores::/diagnóstico [Otros calificadores], Hospitals, Community, colorectal cancer, Community, advanced stage, COVID-19 (Malaltia), Cohort Studies, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [DISEASES], Retrospective Studie, Other subheadings::/diagnosis [Other subheadings], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Humans, Pandemics, Aged, Retrospective Studies, Pandemic, SARS-CoV-2, COVID-19, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], General Medicine, neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales [ENFERMEDADES], Hospitals, Recte - Càncer - Diagnòstic, Settore MED/18, Italy, Còlon - Càncer - Diagnòstic, Cohort Studie, Colorectal Neoplasms, Human
Abstract

ImportanceDelays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis.ObjectiveTo evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer.Design, Setting, and ParticipantsThis retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery.ExposuresAny type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections.Main Outcomes and MeasuresThe primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable.ResultsA total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95% CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95% CI, 1.15-1.53; P P = .03).Conclusions and RelevanceThis cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients.

Published
2022

126. Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy

Author

Luberto, Ferdinando, Ferrante, Daniela, Silvestri, Stefano, Angelini, Alessia, Cuccaro, Francesco, Nannavecchia, Anna Maria, Oddone, Enrico, Vicentini, Massimo, Barone-Adesi, Francesco, Cena, Tiziana, Mirabelli, Dario, Mangone, Lucia, Roncaglia, Francesca, Sala, Orietta, Menegozzo, Simona, Pirastu, Roberta, Azzolina, Danila, Tunesi, Sara, Chellini, Elisabetta, Miligi, Lucia, Perticaroli, Patrizia, Pettinari, Aldo, Bressan, Vittoria, Merler, Enzo, Girardi, Paolo, Bisceglia, Lucia, Marinaccio, Alessandro, Massari, Stefania, Magnani, Corrado, and the working group

Published
2019
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128. Dietary Choline and Betaine Intake and Risk of Colorectal Cancer in an Iranian Population

Author

Seyyedsalehi, Monireh Sadat, primary, Rossi, Marta, additional, Hadji, Maryam, additional, Rashidian, Hamideh, additional, Marzban, Maryam, additional, Parpinel, Maria, additional, Fiori, Federica, additional, Naghibzadeh-Tahami, Ahmad, additional, Hannun, Yusuf A., additional, Luberto, Chiara, additional, Zendehdel, Kazem, additional, and Boffetta, Paolo, additional

Published
2023
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129. Supplementary Data from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

Xie, Stephanie Z., primary, Kaufmann, Kerstin B., primary, Wang, Weijia, primary, Chan-Seng-Yue, Michelle, primary, Gan, Olga I., primary, Laurenti, Elisa, primary, Garcia-Prat, Laura, primary, Takayanagi, Shin-ichiro, primary, Ng, Stanley W.K., primary, Xu, ChangJiang, primary, Zeng, Andy G.X., primary, Jin, Liqing, primary, McLeod, Jessica, primary, Wagenblast, Elvin, primary, Mitchell, Amanda, primary, Kennedy, James A., primary, Liu, Qiang, primary, Boutzen, Héléna, primary, Kleinau, Melissa, primary, Jargstorf, Joseph, primary, Holmes, Gareth, primary, Zhang, Yang, primary, Voisin, Veronique, primary, Bader, Gary D., primary, Wang, Jean C.Y., primary, Hannun, Yusuf A., primary, Luberto, Chiara, primary, Schroeder, Timm, primary, Minden, Mark D., primary, and Dick, John E., primary

Published
2023
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130. Data from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

Xie, Stephanie Z., primary, Kaufmann, Kerstin B., primary, Wang, Weijia, primary, Chan-Seng-Yue, Michelle, primary, Gan, Olga I., primary, Laurenti, Elisa, primary, Garcia-Prat, Laura, primary, Takayanagi, Shin-ichiro, primary, Ng, Stanley W.K., primary, Xu, ChangJiang, primary, Zeng, Andy G.X., primary, Jin, Liqing, primary, McLeod, Jessica, primary, Wagenblast, Elvin, primary, Mitchell, Amanda, primary, Kennedy, James A., primary, Liu, Qiang, primary, Boutzen, Héléna, primary, Kleinau, Melissa, primary, Jargstorf, Joseph, primary, Holmes, Gareth, primary, Zhang, Yang, primary, Voisin, Veronique, primary, Bader, Gary D., primary, Wang, Jean C.Y., primary, Hannun, Yusuf A., primary, Luberto, Chiara, primary, Schroeder, Timm, primary, Minden, Mark D., primary, and Dick, John E., primary

Published
2023
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131. Supplementary Tables from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

Xie, Stephanie Z., primary, Kaufmann, Kerstin B., primary, Wang, Weijia, primary, Chan-Seng-Yue, Michelle, primary, Gan, Olga I., primary, Laurenti, Elisa, primary, Garcia-Prat, Laura, primary, Takayanagi, Shin-ichiro, primary, Ng, Stanley W.K., primary, Xu, ChangJiang, primary, Zeng, Andy G.X., primary, Jin, Liqing, primary, McLeod, Jessica, primary, Wagenblast, Elvin, primary, Mitchell, Amanda, primary, Kennedy, James A., primary, Liu, Qiang, primary, Boutzen, Héléna, primary, Kleinau, Melissa, primary, Jargstorf, Joseph, primary, Holmes, Gareth, primary, Zhang, Yang, primary, Voisin, Veronique, primary, Bader, Gary D., primary, Wang, Jean C.Y., primary, Hannun, Yusuf A., primary, Luberto, Chiara, primary, Schroeder, Timm, primary, Minden, Mark D., primary, and Dick, John E., primary

Published
2023
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132. Supplementary figures merged from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

Xie, Stephanie Z., primary, Kaufmann, Kerstin B., primary, Wang, Weijia, primary, Chan-Seng-Yue, Michelle, primary, Gan, Olga I., primary, Laurenti, Elisa, primary, Garcia-Prat, Laura, primary, Takayanagi, Shin-ichiro, primary, Ng, Stanley W.K., primary, Xu, ChangJiang, primary, Zeng, Andy G.X., primary, Jin, Liqing, primary, McLeod, Jessica, primary, Wagenblast, Elvin, primary, Mitchell, Amanda, primary, Kennedy, James A., primary, Liu, Qiang, primary, Boutzen, Héléna, primary, Kleinau, Melissa, primary, Jargstorf, Joseph, primary, Holmes, Gareth, primary, Zhang, Yang, primary, Voisin, Veronique, primary, Bader, Gary D., primary, Wang, Jean C.Y., primary, Hannun, Yusuf A., primary, Luberto, Chiara, primary, Schroeder, Timm, primary, Minden, Mark D., primary, and Dick, John E., primary

Published
2023
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138. Supplementary Tables from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, and Stephanie Z. Xie

Abstract

Supplementary tables 1 to 14

Published
2023
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139. Supplementary Data from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, and Stephanie Z. Xie

Abstract

Supplemental Movie

Published
2023
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140. Supplementary figures merged from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, and Stephanie Z. Xie

Abstract

Figure S1 to S10

Published
2023
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141. Data from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation

Author

John E. Dick, Mark D. Minden, Timm Schroeder, Chiara Luberto, Yusuf A. Hannun, Jean C.Y. Wang, Gary D. Bader, Veronique Voisin, Yang Zhang, Gareth Holmes, Joseph Jargstorf, Melissa Kleinau, Héléna Boutzen, Qiang Liu, James A. Kennedy, Amanda Mitchell, Elvin Wagenblast, Jessica McLeod, Liqing Jin, Andy G.X. Zeng, ChangJiang Xu, Stanley W.K. Ng, Shin-ichiro Takayanagi, Laura Garcia-Prat, Elisa Laurenti, Olga I. Gan, Michelle Chan-Seng-Yue, Weijia Wang, Kerstin B. Kaufmann, and Stephanie Z. Xie

Abstract

Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis driven from leukemia stem cells (LSC) that share some hematopoietic stem cell (HSC) programs including responsiveness to inflammatory signaling. Although inflammation dysregulates mature myeloid cells and influences stemness programs and lineage determination in HSCs by activating stress myelopoiesis, such roles in LSCs are poorly understood. Here, we show that S1PR3, a receptor for the bioactive lipid sphingosine-1-phosphate, is a central regulator that drives myeloid differentiation and activates inflammatory programs in both HSCs and LSCs. S1PR3-mediated inflammatory signatures varied in a continuum from primitive to mature myeloid states across cohorts of patients with AML, each with distinct phenotypic and clinical properties. S1PR3 was high in LSCs and blasts of mature myeloid samples with linkages to chemosensitivity, whereas S1PR3 activation in primitive samples promoted LSC differentiation leading to eradication. Our studies open new avenues for therapeutic target identification specific for each AML subset.Significance:S1PR3 is a novel regulator of myeloid fate in normal hematopoiesis that is heterogeneously expressed in AML. S1PR3 marks a subset of less primitive AML cases with a distinct inflammatory signature and therefore has clinical implications as both a therapeutic target and a biomarker to distinguish primitive from mature AML.See related commentary by Yang et al., p. 3.This article is highlighted in the In This Issue feature, p. 1

Published
2023
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145. Sphingolipid metabolic flow controls phosphoinositide turnover at the trans‐Golgi network

Author

Capasso, Serena, Sticco, Lucia, Rizzo, Riccardo, Pirozzi, Marinella, Russo, Domenico, Dathan, Nina A, Campelo, Felix, van Galen, Josse, Hölttä‐Vuori, Maarit, Turacchio, Gabriele, Hausser, Angelika, Malhotra, Vivek, Riezman, Isabelle, Riezman, Howard, Ikonen, Elina, Luberto, Chiara, Parashuraman, Seetharaman, Luini, Alberto, and D'Angelo, Giovanni

Published
2017
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148. Erratum for Mor et al., 'Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids'

Author

Visesato Mor, Antonella Rella, Amir M. Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B. Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J. Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B. Desai, Nathan P. Wiederhold, Annette W. Fothergill, William R. Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L. Rodrigues, Chiara Luberto, Leonardo Nimrichter, and Maurizio Del Poeta

Subjects
Microbiology, QR1-502
Published
2018
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149. Characteristics and Experiences of Parents of Children with Learning and Attention Disabilities and Autism Spectrum Disorder: A Mixed Methods Study

Author

Emma Chad-Friedman, Karen A. Kuhlthau, Rachel A. Millstein, Giselle K. Perez, Christina M. Luberto, Lara Traeger, Jacqueline Proszynski, and Elyse Park

Subjects
Social Psychology, mental disorders, behavioral disciplines and activities, Social Sciences (miscellaneous)
Abstract

Parents of children with learning and attention disorders (LAD) and autism spectrum disorder (ASD) experience chronic parenting stress due to the challenges in raising a child with special needs. We used a mixed methods design to examine characteristics and experiences of stress and coping among parents of children with LAD and ASD. We conducted 20 semi-structured focus group interviews with parents of children with LAD ( n = 11) and ASD ( n = 9) and administered a battery of self-report measures of stress and coping to parents of LAD ( n = 53) and ASD ( n = 51) enrolled in a pilot trial. Qualitative findings showed that parents of children with LAD and ASD largely experienced similar sources of stress, but with different intensities due to their children's different difficulties. Quantitative findings reflected high levels of distress among parents of children with LAD and ASD, with parents of children with ASD demonstrating higher distress and poorer overall sleep quality. Stressors experienced by parents of children with ASD arose from more overt challenges associated with having a child with more visible challenges. Parents of children with LAD experienced more subtle challenges of having a child who is less overtly impaired. Findings will aid in the development of targeted stress management interventions.

Published
2021
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150. Internalized stigma among cancer patients enrolled in a smoking cessation trial: The role of cancer type and associations with psychological distress

Author

Jamie S. Ostroff, Elyse R. Park, Julia Rabin, Erica T. Warner, Giselle K. Perez, and Christina M. Luberto

Subjects
medicine.medical_specialty, Social stigma, business.industry, medicine.medical_treatment, Social Stigma, Head and neck cancer, Psycho-oncology, Stigma (botany), Cancer, Experimental and Cognitive Psychology, Disease, Psychological Distress, medicine.disease, Article, Psychiatry and Mental health, Cross-Sectional Studies, Oncology, Head and Neck Neoplasms, Internal medicine, Humans, Medicine, Smoking cessation, Smoking Cessation, business, Depression (differential diagnoses)
Abstract

PURPOSE: Cancer patients who smoke may experience significant stigma due both to their disease, and negative attitudes and beliefs regarding smoking. We investigated whether internalized stigma differed between currently smoking cancer patients diagnosed with lung or head and neck cancers, other smoking related cancers, and non smoking-related cancers, and whether internalized stigma was associated with psychological distress. METHODS: This cross-sectional analysis used baseline data on 293 participants enrolled in a multi-site randomized smoking cessation intervention trial of patients with recently diagnosed cancer. Internalized stigma was assessed using five Internalized Shame items from the Social Impact of Disease Scale. Smoking-related cancers included lung, head and neck, esophageal, bladder, kidney, liver, pancreatic, colorectal, anal, small intestinal, gastric, and cervical. We used multivariable linear regression to examine whether mean internalized stigma levels differed between individuals with lung and head and neck cancers, other smoking-related cancers, and non smoking-related cancers, adjusting for potential confounders. We further examined the association of internalized stigma with depression, anxiety, and perceived stress, overall and among cancer type groups. RESULTS: Thirty-nine percent of participants were diagnosed with lung or head and neck cancer, 21% with another smoking-related cancer, and 40% with a non smoking-related cancer. In multivariable-adjusted models, participants with lung or head and neck cancers (11.6, 95% confidence intervals (CI) = 10.8-12.2; p < 0.0001) or other smoking-related cancers (10.7, 95% CI = 9.8-11.7; p = 0.03) had higher mean internalized stigma scores compared to those non-smoking-related cancers (9.3, 95% CI = 8.6-10.0). We observed similar positive associations between internalized stigma and depressive symptoms, anxiety, and perceived stress among participants with smoking-related and non smoking-related cancers. CONCLUSIONS: Among smokers, those with smoking-related cancers experienced the highest levels of internalized stigma, and greater internalized stigma was associated with greater psychological distress across cancer types. Providers should assess patients for internalized and other forms of stigma, refer patients for appropriate psychosocial support services, and address stigma in smoking cessation programs.

Published
2021
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