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103. Supplementary Tables 1-5, Supplementary Figures 1-3 from Transcriptomes of Prostate Cancer with TMPRSS2:ERG and Other ETS Fusions

Author

Stopsack, Konrad H., primary, Su, Xiaofeng A., primary, Vaselkiv, J. Bailey, primary, Graff, Rebecca E., primary, Ebot, Ericka M., primary, Pettersson, Andreas, primary, Lis, Rosina T., primary, Fiorentino, Michelangelo, primary, Loda, Massimo, primary, Penney, Kathryn L., primary, Lotan, Tamara L., primary, and Mucci, Lorelei A., primary

Published
2023
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104. Supplemental Table 1 from Obesity is Associated with Shorter Telomere Length in Prostate Stromal Cells in Men with Aggressive Prostate Cancer

Author

Joshu, Corinne E., primary, Heaphy, Christopher M., primary, Barber, John R., primary, Lu, Jiayun, primary, Zarinshenas, Reza, primary, Davis, Christine, primary, Han, Misop, primary, Lotan, Tamara L., primary, Sfanos, Karen S., primary, De Marzo, Angelo M., primary, Meeker, Alan K., primary, and Platz, Elizabeth A., primary

Published
2023
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106. Supplementary Figure 2 from Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

Author

Tan, Hsueh-Li, primary, Sood, Akshay, primary, Rahimi, Hameed A., primary, Wang, Wenle, primary, Gupta, Nilesh, primary, Hicks, Jessica, primary, Mosier, Stacy, primary, Gocke, Christopher D., primary, Epstein, Jonathan I., primary, Netto, George J., primary, Liu, Wennuan, primary, Isaacs, William B., primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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107. Supplementary Figure S5 from Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer

Author

Guedes, Liana B., primary, Morais, Carlos L., primary, Almutairi, Fawaz, primary, Haffner, Michael C., primary, Zheng, Qizhi, primary, Isaacs, John T., primary, Antonarakis, Emmanuel S., primary, Lu, Changxue, primary, Tsai, Harrison, primary, Luo, Jun, primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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108. Supplementary Figure S4 from Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas

Author

Tsai, Harrison, primary, Morais, Carlos L., primary, Alshalalfa, Mohammed, primary, Tan, Hsueh-Li, primary, Haddad, Zaid, primary, Hicks, Jessica, primary, Gupta, Nilesh, primary, Epstein, Jonathan I., primary, Netto, George J., primary, Isaacs, William B., primary, Luo, Jun, primary, Mehra, Rohit, primary, Vessella, Robert L., primary, Karnes, R. Jeffrey, primary, Schaeffer, Edward M., primary, Davicioni, Elai, primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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109. Data from PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients

Author

Lotan, Tamara L., primary, Gurel, Bora, primary, Sutcliffe, Siobhan, primary, Esopi, David, primary, Liu, Wennuan, primary, Xu, Jianfeng, primary, Hicks, Jessica L., primary, Park, Ben H., primary, Humphreys, Elizabeth, primary, Partin, Alan W., primary, Han, Misop, primary, Netto, George J., primary, Isaacs, William B., primary, and De Marzo, Angelo M., primary

Published
2023
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110. Supplementary Table S2 from Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer

Author

Guedes, Liana B., primary, Almutairi, Fawaz, primary, Haffner, Michael C., primary, Rajoria, Gaurav, primary, Liu, Zach, primary, Klimek, Szczepan, primary, Zoino, Roberto, primary, Yousefi, Kasra, primary, Sharma, Rajni, primary, De Marzo, Angelo M., primary, Netto, George J., primary, Isaacs, William B., primary, Ross, Ashley E., primary, Schaeffer, Edward M., primary, and Lotan, Tamara L., primary

Published
2023
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111. Table S6 from Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer

Author

Allott, Emma H., primary, Ebot, Ericka M., primary, Stopsack, Konrad H., primary, Gonzalez-Feliciano, Amparo G., primary, Markt, Sarah C., primary, Wilson, Kathryn M., primary, Ahearn, Thomas U., primary, Gerke, Travis A., primary, Downer, Mary K., primary, Rider, Jennifer R., primary, Freedland, Stephen J., primary, Lotan, Tamara L., primary, Kantoff, Philip W., primary, Platz, Elizabeth A., primary, Loda, Massimo, primary, Stampfer, Meir J., primary, Giovannucci, Edward, primary, Sweeney, Christopher J., primary, Finn, Stephen P., primary, and Mucci, Lorelei A., primary

Published
2023
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112. 'Supp Fig S1' from Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer

Author

Guedes, Liana B., primary, Almutairi, Fawaz, primary, Haffner, Michael C., primary, Rajoria, Gaurav, primary, Liu, Zach, primary, Klimek, Szczepan, primary, Zoino, Roberto, primary, Yousefi, Kasra, primary, Sharma, Rajni, primary, De Marzo, Angelo M., primary, Netto, George J., primary, Isaacs, William B., primary, Ross, Ashley E., primary, Schaeffer, Edward M., primary, and Lotan, Tamara L., primary

Published
2023
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113. Supplementary tables from Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a de novo low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer

Author

Spratt, Daniel E., primary, Alshalalfa, Mohammed, primary, Fishbane, Nick, primary, Weiner, Adam B., primary, Mehra, Rohit, primary, Mahal, Brandon A., primary, Lehrer, Jonathan, primary, Liu, Yang, primary, Zhao, Shuang G., primary, Speers, Corey, primary, Morgan, Todd M., primary, Dicker, Adam P., primary, Freedland, Stephen J., primary, Karnes, R. Jeffery, primary, Weinmann, Sheila, primary, Davicioni, Elai, primary, Ross, Ashley E., primary, Den, Robert B., primary, Nguyen, Paul L., primary, Feng, Felix Y., primary, Lotan, Tamara L., primary, Chinnaiyan, Arul M., primary, and Schaeffer, Edward M., primary

Published
2023
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114. Supplementary Table 1 from PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients

Author

Lotan, Tamara L., primary, Gurel, Bora, primary, Sutcliffe, Siobhan, primary, Esopi, David, primary, Liu, Wennuan, primary, Xu, Jianfeng, primary, Hicks, Jessica L., primary, Park, Ben H., primary, Humphreys, Elizabeth, primary, Partin, Alan W., primary, Han, Misop, primary, Netto, George J., primary, Isaacs, William B., primary, and De Marzo, Angelo M., primary

Published
2023
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115. Supp Tables from MSH2 Loss in Primary Prostate Cancer

Author

Guedes, Liana B., primary, Antonarakis, Emmanuel S., primary, Schweizer, Michael T., primary, Mirkheshti, Nooshin, primary, Almutairi, Fawaz, primary, Park, Jong Chul, primary, Glavaris, Stephanie, primary, Hicks, Jessica, primary, Eisenberger, Mario A., primary, De Marzo, Angelo M., primary, Epstein, Jonathan I., primary, Isaacs, William B., primary, Eshleman, James R., primary, Pritchard, Colin C., primary, and Lotan, Tamara L., primary

Published
2023
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116. Supp Fig S2 from MSH2 Loss in Primary Prostate Cancer

Author

Guedes, Liana B., primary, Antonarakis, Emmanuel S., primary, Schweizer, Michael T., primary, Mirkheshti, Nooshin, primary, Almutairi, Fawaz, primary, Park, Jong Chul, primary, Glavaris, Stephanie, primary, Hicks, Jessica, primary, Eisenberger, Mario A., primary, De Marzo, Angelo M., primary, Epstein, Jonathan I., primary, Isaacs, William B., primary, Eshleman, James R., primary, Pritchard, Colin C., primary, and Lotan, Tamara L., primary

Published
2023
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117. Supplementary Figure 1 from Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

Author

Tan, Hsueh-Li, primary, Sood, Akshay, primary, Rahimi, Hameed A., primary, Wang, Wenle, primary, Gupta, Nilesh, primary, Hicks, Jessica, primary, Mosier, Stacy, primary, Gocke, Christopher D., primary, Epstein, Jonathan I., primary, Netto, George J., primary, Liu, Wennuan, primary, Isaacs, William B., primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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118. supplemental legend from Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer

Author

Guedes, Liana B., primary, Morais, Carlos L., primary, Almutairi, Fawaz, primary, Haffner, Michael C., primary, Zheng, Qizhi, primary, Isaacs, John T., primary, Antonarakis, Emmanuel S., primary, Lu, Changxue, primary, Tsai, Harrison, primary, Luo, Jun, primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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119. Data from Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas

Author

Tsai, Harrison, primary, Morais, Carlos L., primary, Alshalalfa, Mohammed, primary, Tan, Hsueh-Li, primary, Haddad, Zaid, primary, Hicks, Jessica, primary, Gupta, Nilesh, primary, Epstein, Jonathan I., primary, Netto, George J., primary, Isaacs, William B., primary, Luo, Jun, primary, Mehra, Rohit, primary, Vessella, Robert L., primary, Karnes, R. Jeffrey, primary, Schaeffer, Edward M., primary, Davicioni, Elai, primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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120. Supplementary figures from Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a de novo low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer

Author

Spratt, Daniel E., primary, Alshalalfa, Mohammed, primary, Fishbane, Nick, primary, Weiner, Adam B., primary, Mehra, Rohit, primary, Mahal, Brandon A., primary, Lehrer, Jonathan, primary, Liu, Yang, primary, Zhao, Shuang G., primary, Speers, Corey, primary, Morgan, Todd M., primary, Dicker, Adam P., primary, Freedland, Stephen J., primary, Karnes, R. Jeffery, primary, Weinmann, Sheila, primary, Davicioni, Elai, primary, Ross, Ashley E., primary, Den, Robert B., primary, Nguyen, Paul L., primary, Feng, Felix Y., primary, Lotan, Tamara L., primary, Chinnaiyan, Arul M., primary, and Schaeffer, Edward M., primary

Published
2023
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121. supp Tables from Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy

Author

Karnes, R. Jeffrey, primary, Sharma, Vidit, primary, Choeurng, Voleak, primary, Ashab, Hussam Al-Deen, primary, Erho, Nicholas, primary, Alshalalfa, Mohammed, primary, Trock, Bruce, primary, Ross, Ashley, primary, Yousefi, Kasra, primary, Tsai, Harrison, primary, Zhao, Shuang G., primary, Tosoian, Jeffrey J., primary, Haddad, Zaid, primary, Takhar, Mandeep, primary, Chang, S. Laura, primary, Spratt, Daniel E., primary, Abdollah, Firas, primary, Jenkins, Robert B., primary, Klein, Eric A., primary, Nguyen, Paul L., primary, Dicker, Adam P., primary, Den, Robert B., primary, Davicioni, Elai, primary, Feng, Felix Y., primary, Lotan, Tamara L., primary, and Schaeffer, Edward M., primary

Published
2023
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122. Supplementary Table S1 from Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer

Author

Guedes, Liana B., primary, Morais, Carlos L., primary, Almutairi, Fawaz, primary, Haffner, Michael C., primary, Zheng, Qizhi, primary, Isaacs, John T., primary, Antonarakis, Emmanuel S., primary, Lu, Changxue, primary, Tsai, Harrison, primary, Luo, Jun, primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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123. supplemental figure legend and Materials and Methods from Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas

Author

Tsai, Harrison, primary, Morais, Carlos L., primary, Alshalalfa, Mohammed, primary, Tan, Hsueh-Li, primary, Haddad, Zaid, primary, Hicks, Jessica, primary, Gupta, Nilesh, primary, Epstein, Jonathan I., primary, Netto, George J., primary, Isaacs, William B., primary, Luo, Jun, primary, Mehra, Rohit, primary, Vessella, Robert L., primary, Karnes, R. Jeffrey, primary, Schaeffer, Edward M., primary, Davicioni, Elai, primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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124. Supplementary Table 1 from Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma

Author

Tan, Hsueh-Li, primary, Sood, Akshay, primary, Rahimi, Hameed A., primary, Wang, Wenle, primary, Gupta, Nilesh, primary, Hicks, Jessica, primary, Mosier, Stacy, primary, Gocke, Christopher D., primary, Epstein, Jonathan I., primary, Netto, George J., primary, Liu, Wennuan, primary, Isaacs, William B., primary, De Marzo, Angelo M., primary, and Lotan, Tamara L., primary

Published
2023
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125. Sup Fig 1 from Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy

Author

Karnes, R. Jeffrey, primary, Sharma, Vidit, primary, Choeurng, Voleak, primary, Ashab, Hussam Al-Deen, primary, Erho, Nicholas, primary, Alshalalfa, Mohammed, primary, Trock, Bruce, primary, Ross, Ashley, primary, Yousefi, Kasra, primary, Tsai, Harrison, primary, Zhao, Shuang G., primary, Tosoian, Jeffrey J., primary, Haddad, Zaid, primary, Takhar, Mandeep, primary, Chang, S. Laura, primary, Spratt, Daniel E., primary, Abdollah, Firas, primary, Jenkins, Robert B., primary, Klein, Eric A., primary, Nguyen, Paul L., primary, Dicker, Adam P., primary, Den, Robert B., primary, Davicioni, Elai, primary, Feng, Felix Y., primary, Lotan, Tamara L., primary, and Schaeffer, Edward M., primary

Published
2023
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126. Supplementary Data from Genomic and Clinicopathologic Characterization of ATM-deficient Prostate Cancer

Author

Kaur, Harsimar, primary, Salles, Daniela C., primary, Murali, Sanjana, primary, Hicks, Jessica L., primary, Nguyen, Minh, primary, Pritchard, Colin C., primary, De Marzo, Angelo M., primary, Lanchbury, Jerry S., primary, Trock, Bruce J., primary, Isaacs, William B., primary, Timms, Kirsten M., primary, Antonarakis, Emmanuel S., primary, and Lotan, Tamara L., primary

Published
2023
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127. Sup Fig 2 from Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy

Author

Karnes, R. Jeffrey, primary, Sharma, Vidit, primary, Choeurng, Voleak, primary, Ashab, Hussam Al-Deen, primary, Erho, Nicholas, primary, Alshalalfa, Mohammed, primary, Trock, Bruce, primary, Ross, Ashley, primary, Yousefi, Kasra, primary, Tsai, Harrison, primary, Zhao, Shuang G., primary, Tosoian, Jeffrey J., primary, Haddad, Zaid, primary, Takhar, Mandeep, primary, Chang, S. Laura, primary, Spratt, Daniel E., primary, Abdollah, Firas, primary, Jenkins, Robert B., primary, Klein, Eric A., primary, Nguyen, Paul L., primary, Dicker, Adam P., primary, Den, Robert B., primary, Davicioni, Elai, primary, Feng, Felix Y., primary, Lotan, Tamara L., primary, and Schaeffer, Edward M., primary

Published
2023
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128. Supplementary Data from CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer

Author

Faisal, Farzana A., primary, Murali, Sanjana, primary, Kaur, Harsimar, primary, Vidotto, Thiago, primary, Guedes, Liana B., primary, Salles, Daniela Correia, primary, Kothari, Vishal, primary, Tosoian, Jeffrey J., primary, Han, Sumin, primary, Hovelson, Daniel H., primary, Hu, Kevin, primary, Spratt, Daniel E., primary, Baras, Alexander S., primary, Tomlins, Scott A., primary, Schaeffer, Edward M., primary, and Lotan, Tamara L., primary

Published
2023
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139. Impact of concurrent tumor events on the prostate cancer outcomes of germline BRCA2 mutation carriers

Author

Lozano, Rebeca, primary, Castro, Elena, additional, Lopez-Campos, Fernando, additional, Thorne, Heather, additional, Ramirez-Backhaus, Miguel, additional, Aragon, Isabel M., additional, Cendón-Florez, Ylenia, additional, Gutierrez-Pecharroman, Ana, additional, Salles, Daniela C., additional, Romero-Laorden, Nuria, additional, Lorente, David, additional, González-Peramato, Pilar, additional, Calatrava, Ana, additional, Alonso, Concepción, additional, Anido, Urbano, additional, Arévalo-Lobera, Sara, additional, Balmaña, Judith, additional, Chirivella, Isabel, additional, Juan-Fita, María José, additional, Llort, Gemma, additional, y Cajal, Teresa Ramón, additional, Almagro, Elena, additional, Alameda, Daniel, additional, López-Casas, Pedro P., additional, Herrera, Bernardo, additional, Mateo, Joaquin, additional, Pritchard, Colin C., additional, Antonarakis, Emmanuel S., additional, Lotan, Tamara L., additional, Rubio-Briones, José, additional, Sandhu, Shahneen, additional, and Olmos, David, additional

Published
2023
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141. Use of prostate cancer subtyping by gene expression to predict response to radiation and chemohormonal therapies.

Author

Weiner, Adam B, primary, Liu, Yang, additional, Hakansson, Alexander K., additional, Zhao, Xin, additional, Proudfoot, James Alexander, additional, Zhang, JJ Haijing, additional, Karnes, R. Jeffrey, additional, Den, Robert Benjamin, additional, Kishan, Amar Upadhyaya, additional, Reiter, Robert Evan, additional, Hamid, Anis, additional, Ross, Ashley, additional, Tran, Phuoc T., additional, Chua, Melvin L.K. Lee Kiang, additional, Spratt, Daniel Eidelberg, additional, Attard, Gerhardt, additional, Lotan, Tamara L., additional, Sweeney, Christopher J, additional, Davicioni, Elai, additional, and Schaeffer, Edward M., additional

Published
2023
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142. Immunomodulatory response to neoadjuvant nivolumab in non-metastatic clear cell renal cell carcinoma.

Author

Singla, Nirmish, primary, Nirschl, Thomas, additional, Obradovic, Aleksandar, additional, Shenderov, Eugene, additional, Lombardo, Kara A., additional, Liu, Xiaopu, additional, Pons, Alice, additional, Zarif, Jelani, additional, Rowe, Steven P., additional, Trock, Bruce J., additional, Hammers, Hans J., additional, Bivalacqua, Trinity, additional, Pierorazio, Phillip, additional, Deutsch, Julie S., additional, Lotan, Tamara L., additional, Taube, Janis M., additional, Ged, Yasser, additional, Gorin, Michael A., additional, Allaf, Mohamad E., additional, and Drake, Charles G., additional

Published
2023
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143. Association of self-identified race and genetic ancestry with the immunogenomic landscape of primary prostate cancer

Author

Vidotto, Thiago, primary, Imada, Eddie L., additional, Faisal, Farzana, additional, Murali, Sanjana, additional, Mendes, Adrianna A., additional, Kaur, Harsimar, additional, Zheng, Siqun, additional, Xu, Jianfeng, additional, Schaeffer, Edward M., additional, Isaacs, William B., additional, Sfanos, Karen S., additional, Marchionni, Luigi, additional, and Lotan, Tamara L., additional

Published
2023
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148. mTORCI loss impairs epidermal adhesion via TGF-[beta]/Rho kinase activation

Author

Asrani, Kaushal, Sood, Akshay, Torres, Alba, Georgess, Dan, Phatak, Pornima, Kaur, Harsimar, Dubin, Amber, Conover Talbot Jr., C., Elhelu, Loubna, Ewald, Andrew J., Xiao, Bo, Worley, Paul, and Lotan, Tamara L.

Subjects
Gene expression -- Research, Transforming growth factors -- Research, Health care industry
Abstract

Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in epithelial development has not been studied extensively in vivo. Here, we have used the epidermis as a model system to elucidate the cellular effects and signaling feedback sequelae of mTORC1 loss of function in epithelial tissue. In mice with conditional epidermal loss of the mTORC1 components Rheb or Rptor, mTORC1 loss of function unexpectedly resulted in a profound skin barrier defect with epidermal abrasions, blistering, and early postnatal lethality, due to a thinned epidermis with decreased desmosomal protein expression and incomplete biochemical differentiation. In mice with mTORC1 loss of function, we found that Rho kinase (ROCK) signaling was constitutively activated, resulting in increased cytoskeletal tension and impaired cell-cell adhesion. Inhibition or silencing of ROCK1 was sufficient to rescue keratinocyte adhesion and biochemical differentiation in these mice. mTORC1 loss of function also resulted in marked feedback upregulation of upstream TGF-[beta] signaling, triggering ROCK activity and its downstream effects on desmosomal gene expression. These findings elucidate a role for mTORC1 in the regulation of epithelial barrier formation, cytoskeletal tension, and cell adhesion, underscoring the complexity of signaling feedback following mTORC1 inhibition., Introduction The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in integrating upstream nutrient inputs to regulate cell proliferation, growth, and metabolism (1). mTOR kinase exists in [...]

Published
2017
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149. Transcriptomes of Prostate Cancer with TMPRSS2:ERG and Other ETS Fusions

Author

Stopsack, Konrad H, Su, Xiaofeng A, Vaselkiv, J Bailey, Graff, Rebecca E, Ebot, Ericka M, Pettersson, Andreas, Lis, Rosina T, Fiorentino, Michelangelo, Loda, Massimo, Penney, Kathryn L, Lotan, Tamara L, and Mucci, Lorelei A

Subjects
Oncogene Proteins, Male, Urologic Diseases, Proto-Oncogene Proteins c-ets, Gene Expression Profiling, Prostate Cancer, Serine Endopeptidases, Human Genome, Oncology and Carcinogenesis, Prostatic Neoplasms, Transcriptional Regulator ERG, Clinical Research, Genetics, Humans, 2.1 Biological and endogenous factors, Oncology & Carcinogenesis, Aetiology, Fusion, Transcriptome, Cancer, Developmental Biology
Abstract

The most common somatic event in primary prostate cancer is a fusion between the androgen-related TMPRSS2 gene and the ERG oncogene. Tumors with these fusions, which occur early in carcinogenesis, have a distinctive etiology. A smaller subset of other tumors harbor fusions between TMPRSS2 and members of the ETS transcription factor family other than ERG. To assess the genomic similarity of tumors with non-ERG ETS fusions and those with fusions involving ERG, this study derived a transcriptomic signature of non-ERG ETS fusions and assessed this signature and ERG-related gene expression in 1,050 men with primary prostate cancer from three independent population-based and hospital-based studies. Although non-ERG ETS fusions involving ETV1, ETV4, ETV5, or FLI1 were individually rare, they jointly accounted for one in seven prostate tumors. Genes differentially regulated between non-ERG ETS tumors and tumors without ETS fusions showed similar differential expression when ERG tumors and tumors without ETS fusions were compared (differences explained: R2 = 69-77%), including ETS-related androgen receptor (AR) target genes. Differences appeared to result from similarities among ETS tumors rather than similarities among non-ETS tumors. Gene sets associated with ERG fusions were consistent with gene sets associated with non-ERG ETS fusions, including fatty acid and amino acid metabolism, an observation that was robust across cohorts.ImplicationsConsidering ETS fusions jointly may be useful for etiologic studies on prostate cancer, given that the transcriptome is profoundly impacted by ERG and non-ERG ETS fusions in a largely similar fashion, most notably genes regulating metabolic pathways.

Published
2023

150. Clonal relationships of adjacent Gleason pattern 3 and Gleason pattern 5 lesions in Gleason Scores 3+5=8 and 5+3=8

Author

Bakbak, Hasim, primary, Sayar, Erolcan, additional, Kaur, Harsimar B., additional, Salles, Daniela C., additional, Patel, Radhika A., additional, Hicks, Jessica, additional, Lotan, Tamara L., additional, De Marzo, Angelo M., additional, Gulati, Roman, additional, Epstein, Jonathan I., additional, and Haffner, Michael C., additional

Published
2022
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