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Textural and compositional attributes of dolomite and calcite within Lower Cretaceous Peterson Limestone micrite indicate that these phases coprecipitated during stabilization of precursor magnesian calcite in a largely closed diagenetic system. Uniform difference in the isotopic compositions of contained carbonate phases over a range of whole rock compositions reflect equilibrium partitioning of18O and13C between dolomite and calcite. Diagenetic dolomite is enriched in18O by 4.4 o/oo and in13C by 1.8 o/oo relative to co-existing calcite, values which are discemibly different from expected open system mixing trends, and which are in general agreement with high temperature fractionation data extrapolated to sedimentary temperatures as well as with calculated δ18O dolomite-calcite from Holocene dolomites.

Minor element and isotopic compositions of marine bivalve calcite are frequently used as proxy records of seawater temperature and salinity. Although molluscan calcite is secreted at or near oxygen isotope equilibrium, the influence of metabolic activity (i.e., vital effects) on skeletal SrCaratios and δ 13C values is not well known. We present measurements of skeletal chemistry from (a) consecutive samples milled in chronological order from the organism's final year of growth and (b) adjacent samples within three separate growth bands of the marine mussel Mytilus trossulusto investigate chemical disequilibrium effects among different parts of the shell.

Coagulation tests were performed before and after institution of conventional therapy, and after clinical remissions, in 35 nonazotemic patients with nephrotic syndrome. Pretreatment studies revealed elevated levels of plasma fibrinogen, factors V, combined VII and X, and VIII, mild thrombocytosis, and accelerated thromboplastin generation. Several thromboembolic complications occurred in these patients and anticoagulant therapy was given to two of them. The abnormal results of tests tended to normalize with clinical remission. It is concluded that the nephrotic syndrome is often associated with blood hypercoagulability and a risk of thromboembolism, and that this may be enhanced by corticosteroid therapy. When renal vein thrombosis occurs it is probably another manifestation of the hypercoagulable state more often than a de novo cause of nephrotic syndrome. Long-term anticoagulant therapy may have a place in the management of nephrotic patients.

Faunal analog reconstructions suggest that Last Interglacial (MIS 5e) sea surface temperatures were cooler around Bermuda and in the Caribbean than modern climate. Here we describe new and revised clumped isotope measurements of Cittarium picafossil shells supporting previous findings of cooler than modern temperatures in Bermuda during the Last Interglacial. We resolve temperature and δ18Owdifferences between two closely located and apparently coeval sites described in Winkelstern et al. (2017), https://doi.org/10.1002/2016pa003014through reprocessing raw isotopic data with the updated Brand/IUPAC parameters. New subannual‐resolution clumped isotope data reveal large variations in δ18Owout of phase with seasonal temperature changes (i.e., lower δ18Owvalues in winter). Supported by modern δ18Owmeasurements identifying similar processes occurring today, we suggest past variations in coastal δ18Owwere driven by seasonally variable freshwater discharge from a subterranean aquifer beneath the island. Taken together, our results emphasize the importance of δ18Owin controlling carbonate δ18O, and suggest that typical assumptions of constant δ18Owshould be made cautiously in nearshore settings and can contribute to less accurate reconstructions of paleotemperature. Bermudan climate during the Last Interglacial period (MIS 5e) was colder than todaySubannual clumped isotope analyses capture seasonal‐scale changes in temperature and water compositionVariable discharge from an underground aquifer affects oxygen isotopic composition of coastal water during MIS 5e and today Bermudan climate during the Last Interglacial period (MIS 5e) was colder than today Subannual clumped isotope analyses capture seasonal‐scale changes in temperature and water composition Variable discharge from an underground aquifer affects oxygen isotopic composition of coastal water during MIS 5e and today