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102. The benefit and risk of stereotactic radiosurgery for prolactinomas: an international multicenter cohort study

Author

Hung, Yi-Chieh, primary, Lee, Cheng-Chia, additional, Yang, Huai-che, additional, Mohammed, Nasser, additional, Kearns, Kathryn N., additional, Nabeel, Ahmed M., additional, Abdel Karim, Khaled, additional, Emad Eldin, Reem M., additional, El-Shehaby, Amr M. N., additional, Reda, Wael A., additional, Tawadros, Sameh R., additional, Liscak, Roman, additional, Jezkova, Jana, additional, Lunsford, L. Dade, additional, Kano, Hideyuki, additional, Sisterson, Nathaniel D., additional, Martínez Álvarez, Roberto, additional, Martínez Moreno, Nuria E., additional, Kondziolka, Douglas, additional, Golfinos, John G., additional, Grills, Inga, additional, Thompson, Andrew, additional, Borghei-Razavi, Hamid, additional, Maiti, Tanmoy Kumar, additional, Barnett, Gene H., additional, McInerney, James, additional, Zacharia, Brad E., additional, Xu, Zhiyuan, additional, and Sheehan, Jason P., additional

Published
2020
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103. Gamma Knife radiosurgery for the treatment of Nelson’s syndrome: a multicenter, international study

Author

Cordeiro, Diogo, primary, Xu, Zhiyuan, additional, Li, Chelsea E., additional, Iorio-Morin, Christian, additional, Mathieu, David, additional, Sisterson, Nathaniel D., additional, Kano, Hideyuki, additional, Attuati, Luca, additional, Picozzi, Piero, additional, Sheehan, Kimball A., additional, Lee, Cheng-chia, additional, Liscak, Roman, additional, Jezkova, Jana, additional, Lunsford, L. Dade, additional, and Sheehan, Jason, additional

Published
2020
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104. Effect of Anatomic Segment Involvement on Stereotactic Radiosurgery for Facial Nerve Schwannomas: An International Multicenter Cohort Study

Author

Mehta, Gautam U, primary, Lekovic, Gregory P, additional, Slattery, William H, additional, Brackmann, Derald E, additional, Long, Hao, additional, Kano, Hideyuki, additional, Kondziolka, Douglas, additional, Mureb, Monica, additional, Bernstein, Kenneth, additional, Langlois, Anne-Marie, additional, Mathieu, David, additional, Nabeel, Ahmed M, additional, Reda, Wael A, additional, Tawadros, Sameh R, additional, Abdelkarim, Khaled, additional, El-Shehaby, Amr M N, additional, Emad, Reem M, additional, Mohammed, Nasser, additional, Urgosik, Dusan, additional, Liscak, Roman, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Montazeripouragha, Amanallah, additional, Kaufmann, Anthony M, additional, Joshi, Krishna C, additional, Barnett, Gene H, additional, Trifiletti, Daniel M, additional, Lunsford, L Dade, additional, and Sheehan, Jason P, additional

Published
2020
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105. Whole Sella vs Targeted Stereotactic Radiosurgery for Acromegaly

Author

Taylor, Davis G, primary, Janssen, Andrew, additional, Ding, Dale, additional, Xu, Zhiyuan, additional, Mehta, Gautam U, additional, Liscak, Roman, additional, Kano, Hideyuki, additional, Kosak, Mikulas, additional, Martinez-Moreno, Nuria, additional, Hobbs, Landon, additional, Chen, Ching-Jen, additional, Grills, Inga S, additional, Mathieu, David, additional, Lunsford, L Dade, additional, Vance, Mary Lee, additional, and Sheehan, Jason P, additional

Published
2020
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106. Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study

Author

Hung, Yi-Chieh, primary, Lee, Cheng-Chia, additional, Yang, Huai-che, additional, Mohammed, Nasser, additional, Kearns, Kathryn N., additional, Sun, Shi-Bin, additional, Mathieu, David, additional, Touchette, Charles J., additional, Atik, Ahmet F., additional, Grills, Inga S., additional, Squires, Bryan, additional, Ding, Dale, additional, Williams, Brian J., additional, Yusuf, Mehran B., additional, Woo, Shiao Y., additional, Liscak, Roman, additional, Hanuska, Jaromir, additional, Shiao, Jay C., additional, Kondziolka, Douglas, additional, Lunsford, L. Dade, additional, Xu, Zhiyuan, additional, and Sheehan, Jason P., additional

Published
2020
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107. Dose response and architecture in volume staged radiosurgery for large arteriovenous malformations: A multi-institutional study

Author

Seymour, Zachary A., primary, Chan, Jason W., additional, Sneed, Penny K., additional, Kano, Hideyuki, additional, Lehocky, Craig A., additional, Jacobs, Rachel C., additional, Ye, Hong, additional, Chytka, Tomas, additional, Liscak, Roman, additional, Lee, Cheng-Chia, additional, Yang, Huai-che, additional, Ding, Dale, additional, Sheehan, Jason, additional, Feliciano, Caleb E., additional, Rodriguez-Mercado, Rafael, additional, Chiang, Veronica L., additional, Hess, Judith A., additional, Sommaruga, Samuel, additional, McShane, Brendan, additional, Lee, John, additional, Vasas, Lucas T., additional, Kaufmann, Anthony M., additional, Grills, Inga, additional, and McDermott, Michael W., additional

Published
2020
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108. international multicenter matched cohort analysis of incidental meningioma progression during active surveillance or after stereotactic radiosurgery: the IMPASSE study.

Author

Sheehan, Jason, Pikis, Stylianos, Islim, Abdurrahman I, Chen, Ching-Jen, Bunevicius, Adomas, Peker, Selcuk, Samanci, Yavuz, Nabeel, Ahmed M, Reda, Wael A, Tawadros, Sameh R, El-Shehaby, Amr M N, Abdelkarim, Khaled, Emad, Reem M, Delabar, Violaine, Mathieu, David, Lee, Cheng-Chia, Yang, Huai-Che, Liscak, Roman, Hanuska, Jaromir, and Alvarez, Roberto Martinez

Published
2022
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109. Stereotactic radiosurgery with versus without prior Onyx embolization for brain arteriovenous malformations.

Author

Ching-Jen Chen, Ding, Dale, Cheng-Chia Lee, Kearns, Kathryn N., Pomeraniec, I. Jonathan, Cifarelli, Christopher P., Arsanious, David E., Liscak, Roman, Hanuska, Jaromir, Williams, Brian J., Yusuf, Mehran B., Woo, Shiao Y., Ironside, Natasha, Burke, Rebecca M., Warnick, Ronald E., Trifiletti, Daniel M., Mathieu, David, Mureb, Monica, Benjamin, Carolina, and Kondziolka, Douglas

Published
2021
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112. Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF)

Author

Cifarelli, Christopher P, primary, Vargo, John A, additional, Fang, Wei, additional, Liscak, Roman, additional, Guseynova, Khumar, additional, Warnick, Ronald E, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Borghei-Razavi, Hamid, additional, Maiti, Tonmoy, additional, Siddiqui, Zaid A, additional, Yuan, Justin C, additional, Grills, Inga S, additional, Mathieu, David, additional, Touchette, Charles J, additional, Cordeiro, Diogo, additional, Chiang, Veronica, additional, Hess, Judith, additional, Tien, Christopher J, additional, Faramand, Andrew, additional, Kano, Hideyuki, additional, Barnett, Gene H, additional, Sheehan, Jason P, additional, and Lunsford, L Dade, additional

Published
2019
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113. Repeat Stereotactic Radiosurgery for Progressive or Recurrent Vestibular Schwannomas

Author

Iorio-Morin, Christian, primary, Liscak, Roman, additional, Vladyka, Vilibald, additional, Kano, Hideyuki, additional, Jacobs, Rachel C, additional, Lunsford, Dade L, additional, Cohen-Inbar, Or, additional, Sheehan, Jason, additional, Emad, Reem, additional, Karim, Khalid Abdel, additional, El-Shehaby, Amr, additional, Reda, Wael A, additional, Lee, Cheng-Chia, additional, Pai, Fu-Yuan, additional, Wolf, Amparo, additional, Kondziolka, Douglas, additional, Grills, Inga, additional, Lee, Kuei C, additional, and Mathieu, David, additional

Published
2019
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114. Hypopituitarism after Gamma Knife radiosurgery for pituitary adenomas: a multicenter, international study

Author

Cordeiro, Diogo, primary, Xu, Zhiyuan, additional, Mehta, Gautam U., additional, Ding, Dale, additional, Vance, Mary Lee, additional, Kano, Hideyuki, additional, Sisterson, Nathaniel, additional, Yang, Huai-che, additional, Kondziolka, Douglas, additional, Lunsford, L. Dade, additional, Mathieu, David, additional, Barnett, Gene H., additional, Chiang, Veronica, additional, Lee, John, additional, Sneed, Penny, additional, Su, Yan-Hua, additional, Lee, Cheng-chia, additional, Krsek, Michal, additional, Liscak, Roman, additional, Nabeel, Ahmed M., additional, El-Shehaby, Amr, additional, Abdel Karim, Khaled, additional, Reda, Wael A., additional, Martinez-Moreno, Nuria, additional, Martinez-Alvarez, Roberto, additional, Blas, Kevin, additional, Grills, Inga, additional, Lee, Kuei C., additional, Kosak, Mikulas, additional, Cifarelli, Christopher P., additional, Katsevman, Gennadiy A., additional, and Sheehan, Jason P., additional

Published
2019
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115. Upfront Gamma Knife radiosurgery for Cushing’s disease and acromegaly: a multicenter, international study

Author

Gupta, Amitabh, primary, Xu, Zhiyuan, additional, Kano, Hideyuki, additional, Sisterson, Nathaniel, additional, Su, Yan-Hua, additional, Krsek, Michal, additional, Nabeel, Ahmed M., additional, El-Shehaby, Amr, additional, Karim, Khaled A., additional, Martínez-Moreno, Nuria, additional, Mathieu, David, additional, McShane, Brendan J., additional, Martínez-Álvarez, Roberto, additional, Reda, Wael A., additional, Liscak, Roman, additional, Lee, Cheng-Chia, additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2019
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117. Stereotactic radiosurgery for central neurocytomas: an international multicenter retrospective cohort study.

Author

Yi-Chieh Hung, Cheng-Chia Lee, Huai-che Yang, Mohammed, Nasser, Kearns, Kathryn N., Shi-Bin Sun, Mathieu, David, Touchette, Charles J., Atik, Ahmet F., Grills, Inga S., Squires, Bryan, Ding, Dale, Williams, Brian J., Yusuf, Mehran B., Woo, Shiao Y., Liscak, Roman, Hanuska, Jaromir, Shiao, Jay C., Kondziolka, Douglas, and Lunsford, L. Dade

Published
2021
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119. Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF).

Author

Cifarelli, Christopher P, Vargo, John A, Fang, Wei, Liscak, Roman, Guseynova, Khumar, Warnick, Ronald E, Lee, Cheng-chia, Yang, Huai-che, Borghei-Razavi, Hamid, Maiti, Tonmoy, Siddiqui, Zaid A, Yuan, Justin C, Grills, Inga S, Mathieu, David, Touchette, Charles J, Cordeiro, Diogo, Chiang, Veronica, Hess, Judith, Tien, Christopher J, and Faramand, Andrew

Published
2020
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120. The benefit and risk of stereotactic radiosurgery for prolactinomas: an international multicenter cohort study.

Author

Yi-Chieh Hung, Cheng-Chia Lee, Huai-che Yang, Mohammed, Nasser, Kearns, Kathryn N., Nabeel, Ahmed M., Karim, Khaled Abdel, Emad Eldin, Reem M., El-Shehaby, Amr M. N., Reda, Wael A., Tawadros, Sameh R., Liscak, Roman, Jezkova, Jana, Lunsford, L. Dade, Hideyuki Kano, Sisterson, Nathaniel D., Martinez Alvarez, Roberto, Martinez Moreno, Nuria E., Kondziolka, Douglas, and Golfinos, John G.

Published
2020
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121. Stereotactic radiosurgery for jugular foramen schwannomas: an international multicenter study

Author

Kano, Hideyuki, primary, Meola, Antonio, additional, Yang, Huai-che, additional, Guo, Wan-Yuo, additional, Martínez-Alvarez, Roberto, additional, Martínez-Moreno, Nuria, additional, Urgosik, Dusan, additional, Liscak, Roman, additional, Cohen-Inbar, Or, additional, Sheehan, Jason, additional, Lee, John Y. K., additional, Abbassy, Mahmoud, additional, Barnett, Gene H., additional, Mathieu, David, additional, Kondziolka, Douglas, additional, and Lunsford, L. Dade, additional

Published
2018
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122. 307 Stereotactic Radiosurgery for Pediatric Intracranial Ependymomas

Author

Kano, Hideyuki, primary, Su, Yan-Hua, additional, Wu, Hsiu-Mei, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Cohen-Inbar, Or, additional, Sheehan, Jason P, additional, Meola, Antonio, additional, Sharma, Mayur, additional, Barnett, Gene H, additional, Mathieu, David, additional, Vasas, Lucas T, additional, Kaufmann, Anthony M, additional, Jacobs, Rachel C, additional, and Lunsford, L. Dade, additional

Published
2018
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123. RONC-10. OUTCOMES OF STEREOTACTIC RADIOSURGERY FOR PILOCYTIC ASTROCYTOMA: AN INTERNATIONAL MULTICENTER STUDY

Author

Murphy, Erin S, primary, Sheehan, Jason P, additional, Trifiletti, Daniel M, additional, Mathieu, David, additional, Kano, Hideyuki, additional, Fang, Fang, additional, Lee, John Y K, additional, McShane, Brendan, additional, Lee, Cheng-chia, additional, Yang, Huai-che, additional, Alvarez, Roberto Martinez, additional, Moreno, Nuria Martinez, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Kondziolka, Douglas, additional, Sharma, Mayur, additional, and Barnett, Gene H, additional

Published
2018
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124. Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study

Author

Ding, Dale, primary, Mehta, Gautam U, additional, Patibandla, Mohana Rao, additional, Lee, Cheng-Chia, additional, Liscak, Roman, additional, Kano, Hideyuki, additional, Pai, Fu-Yuan, additional, Kosak, Mikulas, additional, Sisterson, Nathaniel D, additional, Martinez-Alvarez, Roberto, additional, Martinez-Moreno, Nuria, additional, Mathieu, David, additional, Grills, Inga S, additional, Blas, Kevin, additional, Lee, Kuei, additional, Cifarelli, Christopher P, additional, Katsevman, Gennadiy A, additional, Lee, John Y K, additional, McShane, Brendan, additional, Kondziolka, Douglas, additional, Lunsford, L Dade, additional, Vance, Mary Lee, additional, and Sheehan, Jason P, additional

Published
2018
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125. Stereotactic Radiosurgery for Intracranial Ependymomas: An International Multicenter Study

Author

Kano, Hideyuki, primary, Su, Yan-Hua, additional, Wu, Hsiu-Mei, additional, Simonova, Gabriela, additional, Liscak, Roman, additional, Cohen-Inbar, Or, additional, Sheehan, Jason P, additional, Meola, Antonio, additional, Sharma, Mayur, additional, Barnett, Gene H, additional, Mathieu, David, additional, Vasas, Lucas T, additional, Kaufmann, Anthony M, additional, Jacobs, Rachel C, additional, and Lunsford, L Dade, additional

Published
2018
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126. Stereotactic Radiosurgery for Cushing's Disease: Results of an International, Multicenter Study

Author

Mehta, Gautam, additional, Ding, Dale, additional, Patibandla, Mohana, additional, Kano, Hideyuki, additional, Sisterson, Nathaniel, additional, Su, Yan-Hua, additional, Krsek, Michal, additional, Nabeel, Ahmed, additional, El-Shehaby, Amr, additional, Kareem, Khaled, additional, Martinez-Moreno, Nuria, additional, Mathieu, David, additional, McShane, Brendan, additional, Blas, Kevin, additional, Kondziolka, Douglas, additional, Grills, Inga, additional, Lee, John, additional, Martinez-Alvarez, Roberto, additional, Reda, Wael, additional, Liscak, Roman, additional, Lee, Cheng-Chia, additional, Lunsford, L., additional, Vance, Mary, additional, and Sheehan, Jason, additional

Published
2018
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128. Stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: an international multicenter study

Author

Kano, Hideyuki, primary, Urgosik, Dusan, additional, Liscak, Roman, additional, Pollock, Bruce E., additional, Cohen-Inbar, Or, additional, Sheehan, Jason P., additional, Sharma, Mayur, additional, Silva, Danilo, additional, Barnett, Gene H., additional, Mathieu, David, additional, Sisterson, Nathaniel D., additional, and Lunsford, L. Dade, additional

Published
2016
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129. MRI-guided stereotactic amygdalohippocampectomy: a single center experience

Author

Vojtech, Zdenek, Malikova,Hana, Krámská,Lenka, Liscak,Roman, and Vladyka,Vilibald

Subjects
Neuropsychiatric Disease and Treatment
Abstract

Zdenek Vojtěch,1 Hana Malíková,2 Lenka Krámská,3 Roman LišÄák,4 Vilibald Vladyka41Department of Neurology, 2Department of Radiodiagnostics, 3Department of Psychology, 4Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital,Prague, Czech RepublicBackground: This paper presents our experience of stereotactic radiofrequency amygdalohippocampectomy performed for intractable mesial temporal lobe epilepsy.Methods: The article describes the cases of 61 patients who were treated during the period from 2004 to 2010. Mean postoperative follow-up was 5.3 years. Neuropsychological results were obtained for a subset of 31 patients.Results: At their last postsurgical visit, 43 (70.5%) patients were Engel class I, six (9.8%) class II, nine (14.8%) class III, and three (4.9%) class IV. The surgery was complicated by four intracranial hematomas. One of them caused acute hydrocephalus and was treated by shunting and resolved without sequelae, while another caused transitory aphasia. The remaining hematomas were asymptomatic. There were two cases of meningitis which required antibiotic treatment. One patient committed suicide due to postoperative depression. After the procedure, we performed open epilepsy surgery and rethermolesions in three and two patients, respectively (8.2%). Patients showed increases in their mean full scale, verbal, and performance intelligence quotient (IQ) scores of 4, 3, and 4 IQ points, respectively (P

Published
2015

130. Safety and efficacy of repeat radiosurgery for acromegaly: an International Multi-Institutional Study.

Author

Alonso, Clayton E., Bunevicius, Adomas, Trifiletti, Daniel M., Larner, James, Lee, Cheng-Chia, Pai, Fu-Yuan, Liscak, Roman, Kosak, Mikulas, Kano, Hideyuki, Sisterson, Nathaniel D., Mathieu, David, Lunsford, L. Dade, and Sheehan, Jason P.

Abstract

Purpose: Surgical resection is the first line treatment for growth hormone (GH) secreting tumors. Stereotactic radiosurgery (SRS) is recommended for patients who do not achieve endocrine remission after resection. The purpose of this study was to evaluate safety and efficacy of repeat radiosurgery for acromegaly. Methods: Three hundred and ninety-eight patients with acromegaly treated with the Gamma Knife radiosurgery (Elekta AB, Stockholm) were identified from the International Gamma Knife Research Foundation database. Among these, 21 patients underwent repeated SRS with sufficient endocrine follow-up and 18 patients had sufficient imaging follow-up. Tumor control was defined as lack of adenoma progression on imaging. Endocrine remission was defined as a normal IGF-1 concentration while off medical therapy. Results: Median time from initial SRS to repeat SRS was 5.0 years. The median imaging and endocrine follow-up duration after repeat SRS was 3.4 and 3.8 years, respectively. The median initial marginal dose was 17 Gy, and the median repeat marginal dose was 23 Gy. Of the 18 patients with adequate imaging follow up, 15 (83.3%) patients had tumor control and of 21 patients with endocrine follow-up, 9 (42.9%) patients had endocrine remission at last follow-up visit. Four patients (19.0%) developed new deficits after repeat radiosurgery. Of these, 3 patients had neurologic deficits and 1 patient had endocrine deficit. Conclusions: Repeat radiosurgery for persistent acromegaly offers a reasonable benefit to risk profile for this challenging patient cohort. Further studies are needed to identify patients best suited for this type of approach. [ABSTRACT FROM AUTHOR]

Published
2019
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131. Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study.

Author

Ding, Dale, Mehta, Gautam U, Patibandla, Mohana Rao, Lee, Cheng-Chia, Liscak, Roman, Kano, Hideyuki, Pai, Fu-Yuan, Kosak, Mikulas, Sisterson, Nathaniel D, Martinez-Alvarez, Roberto, Martinez-Moreno, Nuria, Mathieu, David, Grills, Inga S, Blas, Kevin, Lee, Kuei, Cifarelli, Christopher P, Katsevman, Gennadiy A, Lee, John Y K, McShane, Brendan, and Kondziolka, Douglas

Published
2019
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133. Gamma Knife Radiosurgery

Author

Liščák, Roman and Liščák, Roman

Subjects
Radiosurgery, Brain--Surgery
Abstract

This publication aims to give comprehensive information on the methods of gamma knife radiosurgery and the results of treatment of the most frequent diagnoses using radiosurgery. A summarization of existing knowledge and results obtained in gamma knife radiosurgery worldwide is based on experience with treatment of more than 13,500 patients over 20 years at Na Homolce Hospital, Prague. Besides detailing the basic data of Leksell gamma knife radiosurgery, this book also provides thorough technical description of former and existing gamma knife models, basic physics principles of gamma knife radiosurgery, calibration and quality assurance as well as standardized treatment procedures. The book is primarily intended for physicians, who, together with the patient decide on the most appropriate methods of treatment for each diagnosis. The publication can be also helpful to medical physicists who are involved in gamma knife radiosurgery and responsible for its calibration and quality assurance. Finally, it is also intended for patients who are looking for, if necessary, more comprehensive information on the radiosurgical treatment method for tumors and other brain disorders.

Published
2013

135. MRI-guided stereotactic amygdalohippocampectomy: a single center experience

Author

Vojtech,Zdenek, Malikova,Hana, Krámská,Lenka, Liscak,Roman, Vladyka,Vilibald, Vojtech,Zdenek, Malikova,Hana, Krámská,Lenka, Liscak,Roman, and Vladyka,Vilibald

Abstract

Zdenek VojtÄ›ch,1 Hana Malíková,2 Lenka Krámská,3 Roman LišÄák,4 Vilibald Vladyka41Department of Neurology, 2Department of Radiodiagnostics, 3Department of Psychology, 4Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech RepublicBackground: This paper presents our experience of stereotactic radiofrequency amygdalohippocampectomy performed for intractable mesial temporal lobe epilepsy.Methods: The article describes the cases of 61 patients who were treated during the period from 2004 to 2010. Mean postoperative follow-up was 5.3 years. Neuropsychological results were obtained for a subset of 31 patients.Results: At their last postsurgical visit, 43 (70.5%) patients were Engel class I, six (9.8%) class II, nine (14.8%) class III, and three (4.9%) class IV. The surgery was complicated by four intracranial hematomas. One of them caused acute hydrocephalus and was treated by shunting and resolved without sequelae, while another caused transitory aphasia. The remaining hematomas were asymptomatic. There were two cases of meningitis which required antibiotic treatment. One patient committed suicide due to postoperative depression. After the procedure, we performed open epilepsy surgery and rethermolesions in three and two patients, respectively (8.2%). Patients showed increases in their mean full scale, verbal, and performance intelligence quotient (IQ) scores of 4, 3, and 4 IQ points, respectively (P<0.05). Five (17.2%), four (13.8%), and four (13.3%) patients improved their full scale, verbal, and performance IQ scores, respectively. No significant changes were found in memory performance, with a mean increase of 1, 3, and 0 memory quotient points in global, verbal, and visual memory, respectively (P<0.05). Global memory improved in three (10.3%) patients, verbal memory in one (3.4%), and one patient (3.3%) showed deterioration in visual memory.

Published
2015

136. Relationship between remnant hippocampus and amygdala and memory outcomes after stereotactic surgery for mesial temporal lobe epilepsy

Author

Malikova,Hana, Kramska,Lenka, Vojtech,Zdenek, Sroubek,Jan, Lukavsky,Jiri, Liscak,Roman, Malikova,Hana, Kramska,Lenka, Vojtech,Zdenek, Sroubek,Jan, Lukavsky,Jiri, and Liscak,Roman

Abstract

Hana Malikova,1,2,* Lenka Kramska,3,* Zdenek Vojtech,4,5 Jan Sroubek,6 Jiri Lukavsky,7 Roman Liscak8 1Department of Radiology, Na Homolce Hospital, 2Institute of Anatomy, Second Medical Faculty, Charles University in Prague, 3Department of Clinical Psychology, Na Homolce Hospital, 4Department of Neurology, Na Homolce Hospital, 5Department of Neurology, 3rd Medical Faculty, Charles University in Prague, 6Department of Neurosurgery, Na Homolce Hospital, 7Institute of Psychology, Academy of Sciences of the Czech Republic, 8Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, Prague, Czech Republic *These authors contributed equally to this work Background and purpose: Mesial temporal structures play an important role in human memory. In mesial temporal lobe epilepsy (MTLE), seizure activity is generated from the same structures. Surgery is the definitive treatment for medically intractable MTLE. In addition to standard temporal lobe microsurgical resection, stereotactic radiofrequency amygdalohippocampectomy (SAHE) is used as an alternative MTLE treatment. While memory impairments after standard epilepsy surgery are well known, it has been shown that memory decline is not a feature of SAHE. The aim of the present study was to correlate the volume of the remnant hippocampus and amygdala in patients treated by SAHE with changes in memory parameters.Materials and methods: Thirty-seven MTLE patients treated by SAHE (ten right, 27 left) were included. Patients underwent magnetic resonance imaging examinations including hippocampal and amygdalar volumetry and neuropsychological evaluation preoperatively and 1 year after surgery.Results: Using Spearman correlation analyses, larger left-sided hippocampal reductions were associated with lower verbal memory performance (ρ=-0.46; P=0.02). On the contrary, improvement of global memory quotient (MQ) was positively correlated with larger right-sided hippocampal reduction (ρ=0.

Published
2015

138. A neurosurgeon’s view: Outcome after RF-ablation for mTLE.

Author

Malikova, Hana and Liscak, Roman

Subjects
*TEMPORAL lobe epilepsy, *ABLATION techniques, *EPILEPSY surgery, *STEREOTAXIC techniques, *OCCIPITAL lobe, *SPASMS, *THERAPEUTICS
Abstract

We reviewed the current RF-ablation technique for mTLE and complications relating to the procedure. RF-ablation of the amygdalohippocampal complex (AHC) is a stereotactic technique, performed under local anesthesia, which achieved long-term seizure-free clinical seizure outcomes in 71% of mTLE patients. Occipital access is used and thermolesions are made from a single trajectory in the long axis of the AHC. RF-ablation has shown a low complication rate and clinical seizure outcomes seem to be comparable with open surgical techniques. [ABSTRACT FROM AUTHOR]

Published
2018
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140. Диференційоване нейрохірургічне лікування артеріо-венозних мальформацій головного мозку, що проявляються епілептичними нападами

Author

Tsymbaliuk, Vitaliy, Liscak, Roman, Tsimeyko, Orest, Yakovenko, Leonid, Kostiuk, Mykhaylo, Kostiuk, Kostyantyn, Orlov, Mikhail, and Moroz, Volodymyr

Subjects
symptomatic epilepsy, cerebral arteriovenous malformation, endovascular embolization, Gamma-knife surgery, симптоматична епілепсія, артеріо-венозні мальформації головного мозку, ендоваскулярна емболізація, операція з використанням гамма-ножа, симптоматическая эпилепсия, артерио-венозные мальформации головного мозга, эндоваскулярная эмболизация, операция с использованием гамма-ножа
Abstract

Introduction. Intracranial hemorrhages and epileptic seizures are the most common clinical manifestations of cerebral arteriovenous malformations (AVM). The study purpose — to assess efficiency of different surgical methods of symptomatic epilepsy in patients with cerebral AVM.Materials and methods. 67 patients with symptomatic epilepsy brain AVM were included in study. Microsurgical resection (MSR) was performed in 22 patients, endovascular embolization (EE) — in 21, radiosurgical gamma-knife (GK) intervention — in 24. Follow-up period — from 6 months to 10 years, mean — 4.2 years.Results. Complete MSR of AVM was performed in all 22 patients. There were postoperative neurological complications in 6 (27.3%) patients. Total EE of AVM was achieved in 2 (9.5%) patients. Postoperative morbidity observed in 4 (19.1) patients. After GK treatment complete obliteration of AVM was achieved in 17 (70.9%) patients, in 5 patients (20.8%) we observed subtotal occlusion of nidus and 2 (20.8%) patients refused from follow-up instrumental exam. Seizures control of was mostly effective after MSR of AVM — in 19 (86.4%) patients and after GK surgery — in 20 (83.3%), after EE such positive results was achieves just in 6 (28.6%) patients.Conclusions. AVM’s complete resection provides effective control of epileptic seizures. Combined treatment using all methods let to achieve the maximum positive effect in complex brain AVM treatment., Вступление. Внутричерепные кровоизлияния и эпилептические припадки являются наиболее частыми клиническими проявлениями артерио-венозных мальформаций (АВМ) головного мозга. Цель исследования - оценка эффективности различных хирургических методов лечения симптоматической эпилепсии у больных с АВМ головного мозга.Материалы и методы. В исследование включены 67 пациентов с симптоматической эпилепсией и АВМ. Микрохирургическая резекция (МХР) АВМ выполнена у 22 больных, эндоваскулярная эмболизация (ЭЭ) — у 21, радиохирургическая гамма-нож операция (ГН) — у 24. Продолжительность наблюдения от 6 мес до 10 лет, в среднем 4,2 года.Результаты. Тотальная МХР узла АВМ осуществлена у всех 22 больных. У 6 (27,3%) больных возникли неврологические осложнения. Тотальное выключение АВМ после ЭЭ достигнуто у 2 (9,5%) больных. Интраоперационные осложнения возникли у 4 (19,1%) больных. После ГН операции тотальная облитерация АВМ была отмечена у 17 (70,9%) больных, у 5 (20,8%) — уменьшение размеров узла АВМ, 2 (20,8%) пациентов отказались от контрольного обследования. Контроль эпилептических припадков был наиболее эффективным после МХР — у 19 (86,4%) больных и после ГН операции — у 20 (83,3%), после ЭЭ такого результата удалось достичь у 6 (28,6%) больных.Выводы. Тотальное выключение АВМ из кровотока обеспечивает эффективный контроль эпилептических припадков. Комбинированное лечение с использованием всех методов позволяет достичь максимального позитивного эффекта при лечении сложных АВМ головного мозга., Вступ. Внутрішньочерепні крововиливи та епілептичні напади є найбільш частими клінічними проявами артеріо-венозних мальформацій (АВМ) головного мозку. Метою роботи є оцінка ефективності різних хірургічних методів лікування симптоматичної епілепсії у хворих з АВМ головного мозку. Матеріали і методи. У дослідження включені 67 хворих на симптоматичну епілепсію з АВМ головного мозку. Мікрохірургічна резекція (МХР) АВМ виконана у 22 хворих, ендоваскулярна емболізація (ЕЕ) — у 21, радіохірургічна гамма-ніж (ГН) операція — у 24. Тривалість спостереження від 6 міс до 10 років, у середньому 4,2 року.Результати. Тотальну МХР вузла АВМ здійснено в усіх 22 хворих. У 6 (27,3%) хворих після операції виникли неврологічні ускладнення. Тотальної облітерації АВМ після ЕЕ досягнуто у 2 (9,5%) хворих. Інтраопераційні ускладнення виникли у 4 (19,1%) хворих. Після операції з використанням ГН тотальна облітерація АВМ відзначена у 17 (70,9%) хворих, у 5 (20,8%) — встановлене зменшення вузла АВМ, 2 (8,3%) хворих відмовилися від контрольного обстеження. Контроль за нападами був найбільш ефективним після МХР АВМ — у 19 (86,4%) хворих та після ГН операції— у 20 (83,3%), після ЕЕ такого ефекту вдалося досягти у 6 (28,6%) хворих. Висновки. Тотальне виключення АВМ з кровотоку забезпечує ефективний контроль за епілептичними нападами. Комбіноване лікування з використанням усіх трьох методів дає можливість досягти максимально позитивного ефекту лікування складних АВМ головного мозку.

Published
2012

147. Centro-lateral Gamma Knife thalamotomy for intractable pain.

Author

Urgosik, Dusan, May, Jaromir, and Liscak, Roman

Subjects
TRIGEMINAL neuralgia, MAGNETIC resonance imaging, FACIAL pain, POSTHERPETIC neuralgia, THALAMIC nuclei, ANALGESIA, NEURALGIA
Abstract

Objective: Ablative procedures in the treatment of intractable pain are experiencing a renaissance despite the frequent overuse of neuromodulation techniques. Here we present the results of centro-lateral thalamotomy (CLT) in the facial and thalamic pain. Methods and patients: Between 2018 and 2021, we performed unilateral CLT in 16 patients but for the short follow-up we present here 9 of them (F:M=7:2; median age 65 years [range 49–79]) suffering from various severe pain syndromes (4 trigeminal deafferenation pain, 2 trigeminal neuropathic pain, 2 postherpetic trigeminal neuralgia, 1thalamic pain), in whom previous treatment had failed. The median follow up period was 24 months (range 6–28 months). The Leksell Stereotactic Frame, GammaPlan Software (Elekta) and T1- and T2-weighted sequences of magnetic resonance imaging acquired at 1.5 T were used for localization of the targeted central lateral posterior thalamus (CLp). The CLp was localized 6–8 mm lateral to the wall of the 3rd ventricle, 1 mm anterior to the posterior commissure and 5-6 mm superior to the intercommissural line. The CLT was performed by Leksell Gamma Knife with an applied dose ranging from 138 to 145 Gy; single shot, 4 mm collimator. In 7 patients, radiofrequency thermolesion (80°C/60s) at the same target was performed before or after gamma knife CLT to improve the pain relief. Decreased pain intensity to less than 50 - 60% of the previous level was considered as the successful treatment. Results: Initial successful results were achieved in 5 (55.5 %) of the patients. The relief has been achieved after a median latency of 4 - 6 months (range 2–12 months). No neurological deficits were observed. Conclusions: Our results suggest that centro-lateral thalamotomy in patients suffering from severe pain syndromes is a relatively successful and safe method that can be used even in severely affected patients. [ABSTRACT FROM AUTHOR]

Published
2022

148. Leksell Gamma Knife hypophysectomy impact on cancer-related intractable pain.

Author

May, Jaromir, Urgosik, Dusan, and Liscak, Roman

Subjects
CANCER pain, ANALGESIA, LARYNGEAL cancer, STEREOTAXIC techniques, RENAL cancer, DIABETES insipidus, RECTAL cancer, BONE metastasis
Abstract

Introduction: Hypophysectomy is a method used in analgesia in patients with painfull bone metastases. The pain relief after this procedure is not pathophysiologically fully understood but the stimulation of hypothalamic non-opioid pain suppression system is prefered theory nowadays. Firstly this procedure was performed by classical transsphenoidal surgical approach or stereotactic thermocoagulation. In only a few studies Leksell gamma knife (LGK) was used for radiosurgical hypophysectomy. This single-centre study aimed to evaluate the effect and safety of the LGK hypophysectomy in a patient with malignant disease suffering from intractable cancer-related pain. Methods: From 1996 to 2019 we enrolled 19 patients (11F), mean age 59,4 years with the diagnosis of disseminated carcinoma included breast cancer (41%), prostate cancer (23%), lung cancer(18%), kidney cancer (6%), laryngeal cancer (6%) and rectal cancer (6%). All patients underwent radiosurgical hypophysectomy on LGK (model C and Perfexion). The prescription dose was 75-100Gy on 50% isodose line, the maximal dose on the optic pathways was 8-12Gy. Results: The effect of radiosurgical hypophysectomy on pain relief was evaluated in nine patients. In the rest 10 patients, the evaluation was not possible due to bad clinical status (Karnofsky < 60%), they did not come for a visit or they died in consequence of the malignant disease before the effect onset which was from 2 to 4 weeks. In all evaluated patients pain relief was achieved (0-60% of pre-procedural pain). The effect of the hypophysectomy was lasting for the rest of their lives (the mean follow-up period was 14 months). In two patients we observed a side effect - hypocortisolism and diabetes insipidus with good response on substitutional therapy. No other adverse events were observed. Conclusion: Our results suggest that the LGK hypophysectomy is permanently effective and safe procedure to reduce a cancer-related intractable pain especially in bone metastases of hormonally active tumours. [ABSTRACT FROM AUTHOR]

Published
2022

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