16,733 results on '"Lionel P"'
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102. The challenges of using fish cells for cultivated seafood production: Cultivated seafood
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Trace, Angela, Wankell, Miriam, McFarlane, Craig, and Hebbard, Lionel
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- 2024
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103. A Pan-European study of the bacterial plastisphere diversity along river-to-sea continuums
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Philip, Léna, Chapron, Leila, Barbe, Valérie, Burgaud, Gaëtan, Calvès, Isabelle, Paul-Pont, Ika, Thiébeauld, Odon, Sperandio, Brice, Navarro, Lionel, ter Halle, Alexandra, Eyheraguibel, Boris, Ludwig, Wolfgang, Palazot, Maialen, Kedzierski, Mikael, Meistertzheim, Anne-Leila, and Ghiglione, Jean-François
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- 2024
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104. Submicrometre spatiotemporal characterization of the Toxoplasma adhesion strategy for gliding motility
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Vigetti, Luis, Touquet, Bastien, Debarre, Delphine, Rose, Thierry, Bureau, Lionel, Abdallah, Dima, Dubacheva, Galina V., and Tardieux, Isabelle
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- 2024
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105. Functional and structural brain connectivity in disorders of consciousness
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Altmayer, Victor, Sangare, Aude, Calligaris, Charlotte, Puybasset, Louis, Perlbarg, Vincent, Naccache, Lionel, Sitt, Jacobo Diego, and Rohaut, Benjamin
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- 2024
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106. Lessons to Learn from Multimodal Neuromonitoring of Brain Death with Electrophysiological Markers of Cortical and Subcortical Loss of Functions
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Ghibaudo, Valentin, Bado, Jules, Garcia, Samuel, Berthiller, Julien, Rithzenthaler, Thomas, Gobert, Florent, Bapteste, Lionel, Carrillon, Romain, Bodonian, Carole, Dailler, Frédéric, Haegelen, Claire, Dumot, Chloé, Rheims, Sylvain, Berhouma, Moncef, and Balança, Baptiste
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- 2024
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107. Disease severity prognostication in primary sclerosing cholangitis: a validation of the Anali scores and comparison with the potential functional stricture
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Poetter-Lang, Sarah, Ba-Ssalamah, Ahmed, Messner, Alina, Bastati, Nina, Ambros, Raphael, Kristic, Antonia, Kittinger, Jakob, Pochepnia, Svitlana, Ba-Ssalamah, Sami A., Hodge, Jacqueline. C., Halilbasic, Emina, Venkatesh, Sudhakar K., Kartalis, Nikolaos, Ringe, Kristina, Arrivé, Lionel, and Trauner, Michael
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- 2024
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108. Transgelin 2 guards T cell lipid metabolism and antitumour function
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Hwang, Sung-Min, Awasthi, Deepika, Jeong, Jieun, Sandoval, Tito A., Chae, Chang-Suk, Ramos, Yusibeska, Tan, Chen, Marin Falco, Matías, Salvagno, Camilla, Emmanuelli, Alexander, McBain, Ian T., Mishra, Bikash, Ivashkiv, Lionel B., Zamarin, Dmitriy, Cantillo, Evelyn, Chapman-Davis, Eloise, Holcomb, Kevin, Morales, Diana K., Yu, Xiaoqing, Rodriguez, Paulo C., Conejo-Garcia, Jose R., Kaczocha, Martin, Vähärautio, Anna, Song, Minkyung, and Cubillos-Ruiz, Juan R.
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- 2024
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109. Removal of Al3+Fe2+Mn2+, Al3+Fe2+Mn2+, and Al3+Fe2+Mn2+ from quarry water by electrocoagulation process: nature of electrodes, electrodes arrangement, and electrical conductivity influence
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Domergue, Lionel, Hauchard, Didier, and Fourcade, Florence
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- 2024
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110. Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study
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Rabian, Florence, Chevret, Sylvie, Gruson, Bérengère, Thépot, Sylvain, Walter-Petrich, Anouk, Braun, Thorsten, Vey, Norbert, Torregrosa-Diaz, José Miguel, Peterlin, Pierre, Toma, Andrea, D’Aveni, Maud, Delaunay, Jacques, Legros, Laurence, Droin, Nathalie, Chermat, Fatiha, Lusina, Daniel, Adès, Lionel, Sapena, Rosa, Solary, Eric, Fenaux, Pierre, and Itzykson, Raphael
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- 2024
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111. CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia
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Dinakaran, Sajeth, Qutaina, Sima, Zhao, Haitian, Tang, Yuefeng, Wang, Zhimin, Ruiz, Santiago, Nomura-Kitabayashi, Aya, Metz, Christine N., Arthur, Helen M., Meadows, Stryder M., Blanc, Lionel, Faughnan, Marie E., and Marambaud, Philippe
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- 2024
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112. Environmental impact of intravenous versus oral administration materials for acetaminophen and ketoprofen in a French university hospital: an eco-audit study using a life cycle analysis
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Bouvet, Lionel, Juif-Clément, Manon, Bréant, Valentine, Zieleskiewicz, Laurent, Lê, Minh-Quyen, and Cottinet, Pierre-Jean
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- 2024
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113. A New TGF-β Mimetic, XEP™-716 Miniprotein™, Exhibiting Regenerative Properties Objectivized by Instrumental Evaluation
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Chajra, Hanane, Saguet, Thibaut, Granger, Corinne, Breton, Lionel, Pinto, Pedro Contreiras, Machicoane, Mickael, and Le Doussal, Jean Marc
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- 2024
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114. The effect of humeral tray thickness on glenohumeral loads in a reverse shoulder ‘smart’ implant
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Caubère, Alexandre, Rutigliano, Stella, Bourdon, Samuel, Erickson, John, Morelli, Moreno, Parsons, Moby, Neyton, Lionel, and Gauci, Marc-Olivier
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- 2024
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115. Linezolid in enterococcal urinary tract infection: a multicentre study
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Malinowski, Léa, Zayet, Souheil, Chiaruzzi, Myriam, Lefevre, Benjamin, Baronnet, Guillaume, Blot, Mathieu, Klopfenstein, Timothée, Piroth, Lionel, Chirouze, Catherine, Sotto, Albert, and Bouiller, Kevin
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- 2024
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116. Prox-Regular Integro-Differential Sweeping Process
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Gaouir, Sarra, Haddad, Tahar, and Thibault, Lionel
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- 2024
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117. Comparison of scales for the evaluation of aneurysmal subarachnoid haemorrhage: a retrospective cohort study
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Couret, David, Boussen, Salah, Cardoso, Dan, Alonzo, Audrey, Madec, Sylvain, Reyre, Anthony, Brunel, Hervé, Girard, Nadine, Graillon, Thomas, Dufour, Henry, Bruder, Nicolas, Boucekine, Mohamed, Meilhac, Olivier, Simeone, Pierre, and Velly, Lionel
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- 2024
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118. Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate
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Nakano, Felipe Kenji, Åkesson, Anna, de Boer, Jasper, Dedja, Klest, D’hondt, Robbe, Haredasht, Fateme Nateghi, Björk, Jonas, Courbebaisse, Marie, Couzi, Lionel, Ebert, Natalie, Eriksen, Björn O., Dalton, R. Neil, Derain-Dubourg, Laurence, Gaillard, Francois, Garrouste, Cyril, Grubb, Anders, Jacquemont, Lola, Hansson, Magnus, Kamar, Nassim, Legendre, Christophe, Littmann, Karin, Mariat, Christophe, Melsom, Toralf, Rostaing, Lionel, Rule, Andrew D., Schaeffner, Elke, Sundin, Per-Ola, Bökenkamp, Arend, Berg, Ulla, Åsling-Monemi, Kajsa, Selistre, Luciano, Larsson, Anders, Nyman, Ulf, Lanot, Antoine, Pottel, Hans, Delanaye, Pierre, and Vens, Celine
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- 2024
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119. Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning
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Sayegh, Fares J. P., Mouledous, Lionel, Macri, Catherine, Pi Macedo, Juliana, Lejards, Camille, Rampon, Claire, Verret, Laure, and Dahan, Lionel
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- 2024
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120. A Proposal for Combining Project Based Learning and Lean Six Sigma to Teach Robotic Process Automation Development and Enhance Systems Integration
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Money, William H. and Mew, Lionel Q.
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This paper proposes a Project-based team instruction methodology with open-ended projects to teach students critical analysis, design and implementation steps of developing Robotic Process Automation (RPA) for information systems. The use of project-based learning is appropriate for teaching RPA analysis and design with lean Six Sigma tools because of its experimental approach and documentation of logical steps needed to learn how to implement RPA successfully. The approach systematically documents work currently performed and defines future actions of the process while ensuring significant benefits are achieved with the RPA enhanced process. This methodology is important because the application of RPA is not commonly taught in Management Information System (MIS) programs. MIS students may not understand the significance of combined methodology, RPA tool, and usefulness of RPA until they enter the workforce where RPA is rapidly becoming available and easier to implement. The lecture sessions and exercises are valuable because it is easy to communicate the value of RPA in terms of time, quality, volume of transactions, etc. using Lean Six Sigma analytic approaches. The exercises involve hands on activities to make this learning experience interesting for students to readily associate the theoretical process improvement agreement and visualize the practical value of RPA enhanced projects. The paper discusses the need for process changes (and new development approaches) in organization to match the properties and functions within enterprise systems and ERPs that has led to criticism of the enterprise systems. This criticism is attributable to the ERPs' many subfunctions and operations that have limited adaptability and reduced functional and operational flexibility. The RPAs require limited prior knowledge of ERPs or their sub-processes for the improvements that are made in the performance of the organization. Thus, students do not have to "learn" how these enterprise or ERP systems operate to make changes or task improvements. This paper presents a project-based methodology and design approach focusing on development of RPAs that help students learning how to make the improvements using the RPS tools. The students learn that projects can deliver significant and tangible benefits to organizations while engaging students in key activities of the analysis, design and development process from a low code-no code perspective.
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- 2023
121. The Socface Project: Large-Scale Collection, Processing, and Analysis of a Century of French Censuses
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Boillet, Mélodie, Tarride, Solène, Blanco, Manon, Rigal, Valentin, Schneider, Yoann, Abadie, Bastien, Kesztenbaum, Lionel, and Kermorvant, Christopher
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Computer Science - Computer Vision and Pattern Recognition - Abstract
This paper presents a complete processing workflow for extracting information from French census lists from 1836 to 1936. These lists contain information about individuals living in France and their households. We aim at extracting all the information contained in these tables using automatic handwritten table recognition. At the end of the Socface project, in which our work is taking place, the extracted information will be redistributed to the departmental archives, and the nominative lists will be freely available to the public, allowing anyone to browse hundreds of millions of records. The extracted data will be used by demographers to analyze social change over time, significantly improving our understanding of French economic and social structures. For this project, we developed a complete processing workflow: large-scale data collection from French departmental archives, collaborative annotation of documents, training of handwritten table text and structure recognition models, and mass processing of millions of images. We present the tools we have developed to easily collect and process millions of pages. We also show that it is possible to process such a wide variety of tables with a single table recognition model that uses the image of the entire page to recognize information about individuals, categorize them and automatically group them into households. The entire process has been successfully used to process the documents of a departmental archive, representing more than 450,000 images.
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- 2024
122. Tightening I/O Lower Bounds through the Hourglass Dependency Pattern
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Eyraud-Dubois, Lionel, Iooss, Guillaume, Langou, Julien, and Rastello, Fabrice
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Computer Science - Computational Complexity ,Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
When designing an algorithm, one cares about arithmetic/computational complexity, but data movement (I/O) complexity plays an increasingly important role that highly impacts performance and energy consumption. For a given algorithm and a given I/O model, scheduling strategies such as loop tiling can reduce the required I/O down to a limit, called the I/O complexity, inherent to the algorithm itself. The objective of I/O complexity analysis is to compute, for a given program, its minimal I/O requirement among all valid schedules. We consider a sequential execution model with two memories, an infinite one, and a small one of size S on which the computations retrieve and produce data. The I/O is the number of reads and writes between the two memories. We identify a common "hourglass pattern" in the dependency graphs of several common linear algebra kernels. Using the properties of this pattern, we mathematically prove tighter lower bounds on their I/O complexity, which improves the previous state-of-the-art bound by a parametric ratio. This proof was integrated inside the IOLB automatic lower bound derivation tool.
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- 2024
123. Life Cycle Assessment of the Athena X-ray Integral Field Unit
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Barret, Didier, Albouys, Vincent, Knödlseder, Jürgen, Loizillon, Xavier, D'Andrea, Matteo, Ardellier, Florence, Bandler, Simon, Dieleman, Pieter, Duband, Lionel, Dubbeldam, Luc, Macculi, Claudio, Medinaceli, Eduardo, Pajot, Francois, Prêle, Damien, Ravera, Laurent, Thibert, Tanguy, Trallero, Isabel Vera, and Webb, Natalie
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The X-ray Integral Field Unit (X-IFU) is the high-resolution X-ray spectrometer to fly on board the Athena Space Observatory of the European Space Agency (ESA). It is being developed by an international Consortium led by France, involving twelve ESA member states, plus the United States. It is a cryogenic instrument, involving state of the art technology, such as micro-calorimeters, to be read out by low noise electronics. As the instrument was undergoing its system requirement review (in 2022), a life cycle assessment (LCA) was performed to estimate the environmental impacts associated with the development of the sub-systems that were under the responsibility of the X-IFU Consortium. The assessment included the supply, manufacturing and testing of sub systems, as well as involved logistics and manpower. We find that the most significant environmental impacts arise from testing activities, which is related to energy consumption in clean rooms, office work, which is related to energy consumption in office buildings, and instrument manufacturing, which is related to the use of mineral and metal resources. Furthermore, business travels is another area of concern, despite the policy to reduced flying adopted by the Consortium. As the instrument is now being redesigned to fit within the new boundaries set by ESA, the LCA will be updated, with a focus on the hot spots identified in the first iteration. The new configuration, consolidated in 2023, is significantly different from the previously studied version and is marked by an increase of the perimeter of responsibility for the Consortium. This will need to be folded in the updated LCA, keeping the ambition to reduce the environmental footprint of X-IFU, while complying with its stringent requirements in terms of performance and risk management., Comment: 28 pages, 7 figures, accepted for publication in Experimental Astronomy
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- 2024
124. EnzChemRED, a rich enzyme chemistry relation extraction dataset
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Lai, Po-Ting, Coudert, Elisabeth, Aimo, Lucila, Axelsen, Kristian, Breuza, Lionel, de Castro, Edouard, Feuermann, Marc, Morgat, Anne, Pourcel, Lucille, Pedruzzi, Ivo, Poux, Sylvain, Redaschi, Nicole, Rivoire, Catherine, Sveshnikova, Anastasia, Wei, Chih-Hsuan, Leaman, Robert, Luo, Ling, Lu, Zhiyong, and Bridge, Alan
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Computer Science - Computation and Language - Abstract
Expert curation is essential to capture knowledge of enzyme functions from the scientific literature in FAIR open knowledgebases but cannot keep pace with the rate of new discoveries and new publications. In this work we present EnzChemRED, for Enzyme Chemistry Relation Extraction Dataset, a new training and benchmarking dataset to support the development of Natural Language Processing (NLP) methods such as (large) language models that can assist enzyme curation. EnzChemRED consists of 1,210 expert curated PubMed abstracts in which enzymes and the chemical reactions they catalyze are annotated using identifiers from the UniProt Knowledgebase (UniProtKB) and the ontology of Chemical Entities of Biological Interest (ChEBI). We show that fine-tuning pre-trained language models with EnzChemRED can significantly boost their ability to identify mentions of proteins and chemicals in text (Named Entity Recognition, or NER) and to extract the chemical conversions in which they participate (Relation Extraction, or RE), with average F1 score of 86.30% for NER, 86.66% for RE for chemical conversion pairs, and 83.79% for RE for chemical conversion pairs and linked enzymes. We combine the best performing methods after fine-tuning using EnzChemRED to create an end-to-end pipeline for knowledge extraction from text and apply this to abstracts at PubMed scale to create a draft map of enzyme functions in literature to guide curation efforts in UniProtKB and the reaction knowledgebase Rhea. The EnzChemRED corpus is freely available at https://ftp.expasy.org/databases/rhea/nlp/.
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- 2024
125. A Gaussian model of fluctuating membrane and its scattering properties
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Gommes, Cedric J., Dubey, Purushottam S., Stadler, Andreas M., Wu, Baohu, Czakkel, Orsolya, Porcar, Lionel, Jaksch, Sebastian, Frielinghaus, Henrich, and Holderer, Olaf
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Physics - Chemical Physics ,Condensed Matter - Soft Condensed Matter - Abstract
A mathematical model is developed, to jointly analyze elastic and inelastic scattering data of fluctuating membranes within a single theoretical framework. The model builds on a non-homogeneously clipped time-dependent Gaussian random field. This specific approach provides one with general analytical expressions for the intermediate scattering function, for any number of sublayers in the membrane and arbitrary contrasts. The model is illustrated with the analysis of small-angle x-ray and neutron scattering as well as with neutron spin-echo data measured on unilamellar vesicles prepared from phospholipids extracted from porcine brain tissues. The parameters fitted on the entire dataset are the lengths of the chain and head of the molecules that make up the membrane, the amplitude and lateral sizes of the bending deformations, the thickness fluctuation, and a single parameter characterizing the dynamics.
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- 2024
126. SleepVST: Sleep Staging from Near-Infrared Video Signals using Pre-Trained Transformers
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Carter, Jonathan F., Jorge, João, Gibson, Oliver, and Tarassenko, Lionel
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Human-Computer Interaction ,Quantitative Biology - Neurons and Cognition - Abstract
Advances in camera-based physiological monitoring have enabled the robust, non-contact measurement of respiration and the cardiac pulse, which are known to be indicative of the sleep stage. This has led to research into camera-based sleep monitoring as a promising alternative to "gold-standard" polysomnography, which is cumbersome, expensive to administer, and hence unsuitable for longer-term clinical studies. In this paper, we introduce SleepVST, a transformer model which enables state-of-the-art performance in camera-based sleep stage classification (sleep staging). After pre-training on contact sensor data, SleepVST outperforms existing methods for cardio-respiratory sleep staging on the SHHS and MESA datasets, achieving total Cohen's kappa scores of 0.75 and 0.77 respectively. We then show that SleepVST can be successfully transferred to cardio-respiratory waveforms extracted from video, enabling fully contact-free sleep staging. Using a video dataset of 50 nights, we achieve a total accuracy of 78.8\% and a Cohen's $\kappa$ of 0.71 in four-class video-based sleep staging, setting a new state-of-the-art in the domain., Comment: CVPR 2024 Highlight Paper
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- 2024
127. Automatic Coral Detection with YOLO: A Deep Learning Approach for Efficient and Accurate Coral Reef Monitoring
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Younes, Ouassine, Jihad, Zahir, Noël, Conruyt, Mohsen, Kayal, Philippe, A. Martin, Eric, Chenin, Lionel, Bigot, and Regine, Vignes Lebbe
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
Coral reefs are vital ecosystems that are under increasing threat due to local human impacts and climate change. Efficient and accurate monitoring of coral reefs is crucial for their conservation and management. In this paper, we present an automatic coral detection system utilizing the You Only Look Once (YOLO) deep learning model, which is specifically tailored for underwater imagery analysis. To train and evaluate our system, we employ a dataset consisting of 400 original underwater images. We increased the number of annotated images to 580 through image manipulation using data augmentation techniques, which can improve the model's performance by providing more diverse examples for training. The dataset is carefully collected from underwater videos that capture various coral reef environments, species, and lighting conditions. Our system leverages the YOLOv5 algorithm's real-time object detection capabilities, enabling efficient and accurate coral detection. We used YOLOv5 to extract discriminating features from the annotated dataset, enabling the system to generalize, including previously unseen underwater images. The successful implementation of the automatic coral detection system with YOLOv5 on our original image dataset highlights the potential of advanced computer vision techniques for coral reef research and conservation. Further research will focus on refining the algorithm to handle challenging underwater image conditions, and expanding the dataset to incorporate a wider range of coral species and spatio-temporal variations.
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- 2024
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128. Do language models plan ahead for future tokens?
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Wu, Wilson, Morris, John X., and Levine, Lionel
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Computer Science - Machine Learning ,Computer Science - Computation and Language - Abstract
Do transformers "think ahead" during inference at a given position? It is known transformers prepare information in the hidden states of the forward pass at time step $t$ that is then used in future forward passes $t+\tau$. We posit two explanations for this phenomenon: pre-caching, in which off-diagonal gradient terms present during training result in the model computing features at $t$ irrelevant to the present inference task but useful for the future, and breadcrumbs, in which features most relevant to time step $t$ are already the same as those that would most benefit inference at time $t+\tau$. We test these hypotheses by training language models without propagating gradients to past timesteps, a scheme we formalize as myopic training. In a constructed synthetic data setting, we find clear evidence for pre-caching. In the autoregressive language modeling setting, our experiments are more suggestive of the breadcrumbs hypothesis, though pre-caching increases with model scale., Comment: 24 pages, 11 figures. Camera-ready for COLM 2024
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- 2024
129. Towards Reverse-Engineering the Brain: Brain-Derived Neuromorphic Computing Approach with Photonic, Electronic, and Ionic Dynamicity in 3D integrated circuits
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Yoo, S. J. Ben, El-Srouji, Luis, Datta, Suman, Yu, Shimeng, Incorvia, Jean Anne, Salleo, Alberto, Sorger, Volker, Hu, Juejun, Kimerling, Lionel C, Bouchard, Kristofer, Geng, Joy, Chaudhuri, Rishidev, Ranganath, Charan, and O'Reilly, Randall
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Computer Science - Emerging Technologies ,Computer Science - Neural and Evolutionary Computing ,Physics - Optics - Abstract
The human brain has immense learning capabilities at extreme energy efficiencies and scale that no artificial system has been able to match. For decades, reverse engineering the brain has been one of the top priorities of science and technology research. Despite numerous efforts, conventional electronics-based methods have failed to match the scalability, energy efficiency, and self-supervised learning capabilities of the human brain. On the other hand, very recent progress in the development of new generations of photonic and electronic memristive materials, device technologies, and 3D electronic-photonic integrated circuits (3D EPIC ) promise to realize new brain-derived neuromorphic systems with comparable connectivity, density, energy-efficiency, and scalability. When combined with bio-realistic learning algorithms and architectures, it may be possible to realize an 'artificial brain' prototype with general self-learning capabilities. This paper argues the possibility of reverse-engineering the brain through architecting a prototype of a brain-derived neuromorphic computing system consisting of artificial electronic, ionic, photonic materials, devices, and circuits with dynamicity resembling the bio-plausible molecular, neuro/synaptic, neuro-circuit, and multi-structural hierarchical macro-circuits of the brain based on well-tested computational models. We further argue the importance of bio-plausible local learning algorithms applicable to the neuromorphic computing system that capture the flexible and adaptive unsupervised and self-supervised learning mechanisms central to human intelligence. Most importantly, we emphasize that the unique capabilities in brain-derived neuromorphic computing prototype systems will enable us to understand links between specific neuronal and network-level properties with system-level functioning and behavior., Comment: 15 pages, 12 figures
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- 2024
130. On AdS$_4$ deformations of celestial symmetries
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Bittleston, Roland, Bogna, Giuseppe, Heuveline, Simon, Kmec, Adam, Mason, Lionel, and Skinner, David
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics - Abstract
Celestial holography has led to the discovery of new symmetry algebras arising from the study of collinear limits of perturbative gravity amplitudes in flat space. We explain from the twistor perspective how a non-vanishing cosmological constant $\Lambda$ naturally modifies the celestial chiral algebra. The cosmological constant deforms the Poisson bracket on twistor space, so the corresponding deformed algebra of Hamiltonians under the new bracket is automatically consistent. This algebra is equivalent to that recently found by Taylor and Zhu. We find a number of variations of the deformed algebra. We give the Noether charges arising from the expression of this algebra as a symmetry of the twistor action for self-dual gravity with cosmological constant., Comment: 13 pages
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- 2024
131. Gaia23ckh: Symbiotic outburst of the assumed Mira variable V390 Sco
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Merc, Jaroslav, Velez, Peter, Charbonnel, Stéphane, Garde, Olivier, Dû, Pascal Le, Mulato, Lionel, Petit, Thomas, and Skowron, Jan
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The poorly studied variable star V390 Sco, previously classified as a Mira pulsator, was detected in a brightening event by the ESA Gaia satellite in September 2023. This work presents an analysis of available archival multifrequency photometric data of this target, along with our spectroscopic observations. Our findings lead to the conclusion that V390 Sco is a new symbiotic star identified by Gaia, currently undergoing a classical symbiotic outburst. Additionally, we uncovered three prior outbursts of this system through archival photometry. The outbursts recur approximately every 2330 - 2400 days, and we hypothesize the periastron passage in an eccentric orbit may trigger them, similarly to the case of BX Mon, DD Mic, or MWC 560. A detailed investigation into the nature of the donor star suggested that V390 Sco is an S-type symbiotic star, likely hosting a less evolved, semiregularly pulsating giant donor, but not a Mira variable., Comment: 9 pages, 9 figures, 1 table; accepted in Astronomische Nachrichten
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- 2024
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132. Zero123-6D: Zero-shot Novel View Synthesis for RGB Category-level 6D Pose Estimation
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Di Felice, Francesco, Remus, Alberto, Gasperini, Stefano, Busam, Benjamin, Ott, Lionel, Tombari, Federico, Siegwart, Roland, and Avizzano, Carlo Alberto
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Estimating the pose of objects through vision is essential to make robotic platforms interact with the environment. Yet, it presents many challenges, often related to the lack of flexibility and generalizability of state-of-the-art solutions. Diffusion models are a cutting-edge neural architecture transforming 2D and 3D computer vision, outlining remarkable performances in zero-shot novel-view synthesis. Such a use case is particularly intriguing for reconstructing 3D objects. However, localizing objects in unstructured environments is rather unexplored. To this end, this work presents Zero123-6D, the first work to demonstrate the utility of Diffusion Model-based novel-view-synthesizers in enhancing RGB 6D pose estimation at category-level, by integrating them with feature extraction techniques. Novel View Synthesis allows to obtain a coarse pose that is refined through an online optimization method introduced in this work to deal with intra-category geometric differences. In such a way, the outlined method shows reduction in data requirements, removal of the necessity of depth information in zero-shot category-level 6D pose estimation task, and increased performance, quantitatively demonstrated through experiments on the CO3D dataset., Comment: 6 pages, 2 reference pages, 4 figures
- Published
- 2024
133. Theoretical Study on Optoelectronic properties of Layered In2O3 and Ga2O3
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Lionel, Chrislene, Das, Shubham, Banik, Diparnab, and Koley, S.
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Condensed Matter - Materials Science - Abstract
Composite oxides have been indeed proved to be valuable materials in optoelectronic applications. The combination of indium oxide and gallium oxide and other materials can lead to enhanced optical and electronic properties, making them suitable for a variety of optoelectronic devices. Meticulous analysis of the various optical properties helped to draw conclusions about the heterostructure of Indium and Gallium oxide and its use as a suitable semiconducting material in the medium bandgap range. The density of states and the band structure have been obtained from the density functional theory calculations. Real frequency phonon density of states supports dynamical stability of the crystal structure. A favorable energy band gap is achieved in the visible region of the spectrum, indicating that this mixed oxide is well suited for optoelectronic devices such as LEDs and solar cells.
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- 2024
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134. Performance of graphene Hall effect sensors: role of bias current, disorder and Fermi velocity
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Petit, Lionel, Fournier, Tom, Ballon, Géraldine, Robert, Cédric, Lagarde, Delphine, Puech, Pascal, Blon, Thomas, and Lassagne, Benjamin
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Applied Physics - Abstract
Graphene Hall effect magnetic field sensors hold great promise for the development of ultra-sensitive magnetometers. Their performance is frequently analysed using the two-channel model where electron and hole conductivities are simply added. Unfortunately, this model is unable to capture all the features of the sensor, particularly the bias current dependence of the magnetic field sensitivity. Here we present an advanced model that provides an in-depth understanding of how graphene Hall sensors operate, and demonstrate its ability to quantitatively assess their performance. First, we report the fabrication of sensors with different qualities of graphene, with the best devices achieving magnetic field sensitivities as high as 5000 ohms/T, outperforming the best silicon and narrow-gap semiconductor-based sensors. Then, we examine their performance in detail using the proposed numerical model, which combines Boltzmann formalism, with distinct Fermi levels for electrons and holes, and a new method for the introduction of substrate-induced electron-hole puddles. Importantly, the dependences of magnetic field sensitivity on bias current, disorder, substrate and Hall bar geometry are quantitatively reproduced for the first time. In addition, the model emphasizes that the performance of devices with widths of the order of the charge carrier diffusion length, is significantly affected by the bias current due to the occurrence of large and non-symmetric carrier accumulation and depletion areas near the edges of the Hall bar. The formation of these areas induces a transverse diffusion particle flux capable of counterbalancing the particle flux induced by the Lorentz force when the Hall electric field cancels out in the ambipolar regime. Finally, we discuss how sensor performance can be enhanced by Fermi velocity engineering, paving the way for future ultra-sensitive graphene Hall effect sensors., Comment: 29 pages including supplemental material, 12 figures in the main text and 7 figures in the supplemental material
- Published
- 2024
135. A preconditioning for the spectral solution of incompressible variable-density flows
- Author
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Reynier, L., Di Pierro, Bastien, Alizard, Frédéric, Cadiou, Anne, Penven, Lionel Le, and Buffat, Marc
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Physics - Fluid Dynamics ,Mathematics - Numerical Analysis - Abstract
In the present study, the efficiency of preconditioners for solving linear systems associated with the discretized variable-density incompressible Navier-Stokes equations with semiimplicit second-order accuracy in time and spectral accuracy in space is investigated. The method, in which the inverse operator for the constant-density flow system acts as preconditioner, is implemented for three iterative solvers: the General Minimal Residual, the Conjugate Gradient and the Richardson Minimal Residual. We discuss the method, first, in the context of the one-dimensional flow case where a top-hat like profile for the density is used. Numerical evidence shows that the convergence is significantly improved due to the notable decrease in the condition number of the operators. Most importantly, we then validate the robustness and convergence properties of the method on two more realistic problems: the two-dimensional Rayleigh-Taylor instability problem and the three-dimensional variable-density swirling jet.
- Published
- 2024
- Full Text
- View/download PDF
136. On the mutual exclusiveness of time and position in quantum physics and the corresponding uncertainty relation for free falling particles
- Author
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Beau, Mathieu and Martellini, Lionel
- Subjects
Quantum Physics ,General Relativity and Quantum Cosmology ,Mathematical Physics - Abstract
The uncertainty principle is one of the characteristic properties of quantum theory, where it signals the incompatibility of two types of measurements. In this paper, we argue that measurements of time-of-arrival $T_x$ at position $x$ and position $X_t$ at time $t$ are mutually exclusive for a quantum system, each providing complementary information about the state of that system. For a quantum particle of mass $m$ falling in a uniform gravitational field $g$, we show that the corresponding uncertainty relation can be expressed as $\Delta T_x \Delta X_t \geq \frac{\hbar}{2mg}$. This uncertainty relationship can be taken as evidence of the presence of a form of epistemic incompatibility in the sense that preparing the initial state of the system so as to decrease the measured position uncertainty will lead to an increase in the measured time-of-arrival uncertainty. These findings can be empirically tested in the context of ongoing or forthcoming experiments on measurements of time-of-arrival for free-falling quantum particles., Comment: 7 pages, 2 figures, 2 pages supplementary material
- Published
- 2024
137. Strategic Bidding in Knapsack Auctions
- Author
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Khezr, Peyman, Mohan, Vijay, and Page, Lionel
- Subjects
Computer Science - Computer Science and Game Theory ,Economics - Theoretical Economics - Abstract
This paper examines knapsack auctions as a method to solve the knapsack problem with incomplete information, where object values are private and sizes are public. We analyze three auction types-uniform price (UP), discriminatory price (DP), and generalized second price (GSP)-to determine efficient resource allocation in these settings. Using a Greedy algorithm for allocating objects, we analyze bidding behavior, revenue and efficiency of these three auctions using theory, lab experiments, and AI-enriched simulations. Our results suggest that the uniform-price auction has the highest level of truthful bidding and efficiency while the discriminatory price and the generalized second-price auctions are superior in terms of revenue generation. This study not only deepens the understanding of auction-based approaches to NP-hard problems but also provides practical insights for market design.
- Published
- 2024
138. Exploitation of the nonresonant background of Multiplex-Coherent anti-Stokes Raman Scattering for label-free discrimination of proteins
- Author
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Nafa, Malik, Mansuryan, Tigran, Couderc, Vincent, Tonello, Alessandro, Rechignat, Lionel, Fabert, Marc, Magnol, Laetitia, Blanquet, Véronique, Baraige, Fabienne, Carrion, Claire, Duclère, Jean-René, and Lefort, Claire
- Subjects
Physics - Medical Physics ,Physics - Optics - Abstract
We propose a novel approach using Multiplex-Coherent Anti-Stokes Raman Scattering (M-CARS) for la-bel-free discriminations in biomedical tissues. The strategy is based on the evaluation of the contrast be-tween resonant and nonresonant contributions in a M-CARS hyperspectral dataset, and tested to identify and differentiate thin actin filaments from thick myosin filaments in muscle tissue without any labeling. First step consists in ensuring knowledge of the spatial regions containing thick myosin filaments thanks to its endogenous second harmonic signal, deducing expected location for thin actin filaments between myosin filaments. The ratio of resonant and nonresonant contributions for each pixel of the hyperspectral image allows then to discriminate actin from myosin filaments, whose localization is in accordance with the SHG probing. This qualitative imaging represents a proof of principle for highlighting and discriminat-ing purposes in biological microscopy, thanks to the difference in the nonlinear properties of the related proteins. This paves the way for considering label-free imaging through a competition between two third-order nonlinear signatures., Comment: 12 pages, 5 figures
- Published
- 2024
139. The expansion of half-integral polytopes
- Author
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Cardinal, Jean and Pournin, Lionel
- Subjects
Mathematics - Combinatorics ,Computer Science - Computational Geometry ,Computer Science - Discrete Mathematics ,Mathematics - Metric Geometry - Abstract
The expansion of a polytope is an important parameter for the analysis of the random walks on its graph. A conjecture of Mihai and Vazirani states that all $0/1$-polytopes have expansion at least 1. We show that the generalization to half-integral polytopes does not hold by constructing $d$-dimensional half-integral polytopes whose expansion decreases exponentially fast with $d$. We also prove that the expansion of half-integral zonotopes is uniformly bounded away from $0$. As an intermediate result, we show that half-integral zonotopes are always graphical., Comment: 18 pages, 1 figure
- Published
- 2024
140. Getting into the Flow: Towards Better Type Error Messages for Constraint-Based Type Inference
- Author
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Bhanuka, Ishan, Parreaux, Lionel, Binder, David, and Brachthäuser, Jonathan Immanuel
- Subjects
Computer Science - Programming Languages ,Computer Science - Human-Computer Interaction - Abstract
Creating good type error messages for constraint-based type inference systems is difficult. Typical type error messages reflect implementation details of the underlying constraint-solving algorithms rather than the specific factors leading to type mismatches. We propose using subtyping constraints that capture data flow to classify and explain type errors. Our algorithm explains type errors as faulty data flows, which programmers are already used to reasoning about, and illustrates these data flows as sequences of relevant program locations. We show that our ideas and algorithm are not limited to languages with subtyping, as they can be readily integrated with Hindley-Milner type inference. In addition to these core contributions, we present the results of a user study to evaluate the quality of our messages compared to other implementations. While the quantitative evaluation does not show that flow-based messages improve the localization or understanding of the causes of type errors, the qualitative evaluation suggests a real need and demand for flow-based messages., Comment: Technical report version
- Published
- 2024
- Full Text
- View/download PDF
141. Shaping Human-AI Collaboration: Varied Scaffolding Levels in Co-writing with Language Models
- Author
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Dhillon, Paramveer S., Molaei, Somayeh, Li, Jiaqi, Golub, Maximilian, Zheng, Shaochun, and Robert, Lionel P.
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Computation and Language - Abstract
Advances in language modeling have paved the way for novel human-AI co-writing experiences. This paper explores how varying levels of scaffolding from large language models (LLMs) shape the co-writing process. Employing a within-subjects field experiment with a Latin square design, we asked participants (N=131) to respond to argumentative writing prompts under three randomly sequenced conditions: no AI assistance (control), next-sentence suggestions (low scaffolding), and next-paragraph suggestions (high scaffolding). Our findings reveal a U-shaped impact of scaffolding on writing quality and productivity (words/time). While low scaffolding did not significantly improve writing quality or productivity, high scaffolding led to significant improvements, especially benefiting non-regular writers and less tech-savvy users. No significant cognitive burden was observed while using the scaffolded writing tools, but a moderate decrease in text ownership and satisfaction was noted. Our results have broad implications for the design of AI-powered writing tools, including the need for personalized scaffolding mechanisms., Comment: Appearing at CHI 2024 (Honolulu, HI)
- Published
- 2024
142. AIM: Automated Input Set Minimization for Metamorphic Security Testing
- Author
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Chaleshtari, Nazanin Bayati, Marquer, Yoann, Pastore, Fabrizio, and Briand, Lionel C.
- Subjects
Computer Science - Cryptography and Security ,Computer Science - Software Engineering - Abstract
Although the security testing of Web systems can be automated by generating crafted inputs, solutions to automate the test oracle, i.e., vulnerability detection, remain difficult to apply in practice. Specifically, though previous work has demonstrated the potential of metamorphic testing, security failures can be determined by metamorphic relations that turn valid inputs into malicious inputs, metamorphic relations are typically executed on a large set of inputs, which is time-consuming and thus makes metamorphic testing impractical. We propose AIM, an approach that automatically selects inputs to reduce testing costs while preserving vulnerability detection capabilities. AIM includes a clustering-based black-box approach, to identify similar inputs based on their security properties. It also relies on a novel genetic algorithm to efficiently select diverse inputs while minimizing their total cost. Further, it contains a problem-reduction component to reduce the search space and speed up the minimization process. We evaluated the effectiveness of AIM on two well-known Web systems, Jenkins and Joomla, with documented vulnerabilities. We compared AIM's results with four baselines involving standard search approaches. Overall, AIM reduced metamorphic testing time by 84% for Jenkins and 82% for Joomla, while preserving the same level of vulnerability detection. Furthermore, AIM significantly outperformed all the considered baselines regarding vulnerability coverage.
- Published
- 2024
- Full Text
- View/download PDF
143. A Simple Modeling for Gas Release During Annealing of Irradiated Nuclear Fuel
- Author
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Losfeld, Jimmy, Desgranges, Lionel, Pontillon, Yves, and Baldinozzi, Gianguido
- Subjects
Condensed Matter - Materials Science - Abstract
We have developed a gas flow model in the spent nuclear fuel during the annealing. It postulates that the gas release during an isothermal plateau at 1200{\textdegree}C corresponds to the equilibrium between overpressure gas reservoirs in the fuel sample connected to the free surface at atmospheric pressure.
- Published
- 2024
144. Grounding Language about Belief in a Bayesian Theory-of-Mind
- Author
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Ying, Lance, Zhi-Xuan, Tan, Wong, Lionel, Mansinghka, Vikash, and Tenenbaum, Joshua
- Subjects
Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
Despite the fact that beliefs are mental states that cannot be directly observed, humans talk about each others' beliefs on a regular basis, often using rich compositional language to describe what others think and know. What explains this capacity to interpret the hidden epistemic content of other minds? In this paper, we take a step towards an answer by grounding the semantics of belief statements in a Bayesian theory-of-mind: By modeling how humans jointly infer coherent sets of goals, beliefs, and plans that explain an agent's actions, then evaluating statements about the agent's beliefs against these inferences via epistemic logic, our framework provides a conceptual role semantics for belief, explaining the gradedness and compositionality of human belief attributions, as well as their intimate connection with goals and plans. We evaluate this framework by studying how humans attribute goals and beliefs while watching an agent solve a doors-and-keys gridworld puzzle that requires instrumental reasoning about hidden objects. In contrast to pure logical deduction, non-mentalizing baselines, and mentalizing that ignores the role of instrumental plans, our model provides a much better fit to human goal and belief attributions, demonstrating the importance of theory-of-mind for a semantics of belief., Comment: Published at CogSci 2024
- Published
- 2024
145. nuance: Efficient detection of planets transiting active stars
- Author
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Garcia, Lionel, Foreman-Mackey, Daniel, Murray, Catriona A., Aigrain, Suzanne, Feliz, Dax L., and Pozuelos, Francisco J.
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The detection of planetary transits in the light curves of active stars, featuring correlated noise in the form of stellar variability, remains a challenge. Depending on the noise characteristics, we show that the traditional technique that consists of detrending a light curve before searching for transits alters their signal-to-noise ratio, and hinders our capability to discover exoplanets transiting rapidly-rotating active stars. We present nuance, an algorithm to search for transits in light curves while simultaneously accounting for the presence of correlated noise, such as stellar variability and instrumental signals. We assess the performance of nuance on simulated light curves as well as on the TESS light curves of 438 rapidly-rotating M dwarfs. For each dataset, we compare our method to 5 commonly-used detrending techniques followed by a search with the Box-Least-Square algorithm. Overall, we demonstrate that nuance is the most performant method in 93% of cases, leading to both the highest number of true positives and the lowest number of false positive detections. Although simultaneously searching for transits while modeling correlated noise is expected to be computationally expensive, we make our algorithm tractable and available as the JAX-powered Python package nuance, allowing its use on distributed environments and GPU devices. Finally, we explore the prospects offered by the nuance formalism, and its use to advance our knowledge of planetary systems around active stars, both using space-based surveys and sparse ground-based observations.
- Published
- 2024
146. QuantAgent: Seeking Holy Grail in Trading by Self-Improving Large Language Model
- Author
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Wang, Saizhuo, Yuan, Hang, Ni, Lionel M., and Guo, Jian
- Subjects
Computer Science - Artificial Intelligence ,Quantitative Finance - Computational Finance - Abstract
Autonomous agents based on Large Language Models (LLMs) that devise plans and tackle real-world challenges have gained prominence.However, tailoring these agents for specialized domains like quantitative investment remains a formidable task. The core challenge involves efficiently building and integrating a domain-specific knowledge base for the agent's learning process. This paper introduces a principled framework to address this challenge, comprising a two-layer loop.In the inner loop, the agent refines its responses by drawing from its knowledge base, while in the outer loop, these responses are tested in real-world scenarios to automatically enhance the knowledge base with new insights.We demonstrate that our approach enables the agent to progressively approximate optimal behavior with provable efficiency.Furthermore, we instantiate this framework through an autonomous agent for mining trading signals named QuantAgent. Empirical results showcase QuantAgent's capability in uncovering viable financial signals and enhancing the accuracy of financial forecasts.
- Published
- 2024
147. A roadmap for the atmospheric characterization of terrestrial exoplanets with JWST
- Author
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de Wit, Julien, Doyon, Rene, Rackham, Benjamin V, Lim, Olivia, Ducrot, Elsa, Kreidberg, Laura, Benneke, Bjoern, Ribas, Ignasi, Berardo, David, Niraula, Prajwal, Iyer, Aishwarya, Shapiro, Alexander, Kostogryz, Nadiia, Witzke, Veronika, Gillon, Michael, Agol, Eric, Meadows, Victoria, Burgasser, Adam J, Owen, James E, Fortney, Jonathan J, Selsis, Franck, Bello-Arufe, Aaron, de Beurs, Zoe, Bolmont, Emeline, Cowan, Nicolas, Dong, Chuanfei, Drake, Jeremy J, Garcia, Lionel, Greene, Thomas, Haworth, Thomas, Hu, Renyu, Kane, Stephen R, Kervella, Pierre, Koll, Daniel, Krissansen-Totton, Joshua, Lagage, Pierre-Olivier, Lichtenberg, Tim, Lustig-Yaeger, Jacob, Lingam, Manasvi, Turbet, Martin, Seager, Sara, Barkaoui, Khalid, Bell, Taylor J, Burdanov, Artem, Cadieux, Charles, Charnay, Benjamin, Cloutier, Ryan, Cook, Neil J, Correia, Alexandre CM, Dang, Lisa, Daylan, Tansu, Delrez, Laetitia, Edwards, Billy, Fauchez, Thomas J, Flagg, Laura, Fraschetti, Federico, Haqq-Misra, Jacob, Huang, Ziyu, Iro, Nicolas, Jayawardhana, Ray, Jehin, Emmanuel, Jin, Meng, Kite, Edwin, Kitzmann, Daniel, Kral, Quentin, Lafreniere, David, Libert, Anne-Sophie, Liu, Beibei, Mohanty, Subhanjoy, Morris, Brett M, Murray, Catriona A, Piaulet, Caroline, Pozuelos, Francisco J, Radica, Michael, Ranjan, Sukrit, Rathcke, Alexander, Roy, Pierre-Alexis, Schwieterman, Edward W, Turner, Jake D, Triaud, Amaury, and Way, Michael J
- Subjects
Astronomical Sciences ,Physical Sciences ,Astronomical sciences ,Particle and high energy physics ,Space sciences - Published
- 2024
148. Risk Prediction for Clonal Cytopenia: Multicenter Real-World Evidence.
- Author
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Xie, Zhuoer, Komrokji, Rami S, Al-Ali, Najla, Regelson, Alexandra, Geyer, Susan, Patel, Anand A, Saygin, Caner, Zeidan, Amer M, Bewersdorf, Jan Philipp, Mendez, Lourdes M, Kishtagari, Ashwin, Zeidner, Joshua F, Coombs, Catherine C, Madanat, Yazan F, Chung, Stephen S, Badar, Talha, Foran, James M, Desai, Pinkal, Tsai, Charlton, Griffiths, Elizabeth A, Al Malki, Monzr M, Amanam, Idoroenyi, Lai, Catherine, Deeg, H Joachim, Ades, Lionel, Arana-Yi, Cecilia, Osman, Afaf Eg, Dinner, Shira Naomi, Abaza, Yasmin, Taylor, Justin, Chandhok, Namrata S, Soong, Deborah, Brunner, Andrew M, Carraway, Hetty E, Singh, Abhay, Elena, Chiara, Ferrari, Jacqueline, Galli, Anna, Pozzi, Sara, Padron, Eric, Patnaik, Mrinal M, Malcovati, Luca, Savona, Michael R, and Al-Kali, Aref
- Subjects
Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Immunology ,Biochemistry and cell biology ,Cardiovascular medicine and haematology ,Paediatrics - Abstract
Clonal cytopenia of undetermined significance (CCUS) represents a distinct disease entity characterized by myeloid-related somatic mutations with a variant allele fraction of ≥2% in individuals with unexplained cytopenia(s) but without a myeloid neoplasm (MN). Notably, CCUS carries a risk of progressing to MN, particularly in cases featuring high-risk mutations. Understanding CCUS requires dedicated studies to elucidate its risk factors and natural history. Our analysis of 357 CCUS patients investigated the interplay between clonality, cytopenia, and prognosis. Multivariate analysis identified 3 key adverse prognostic factors: the presence of splicing mutation(s) (score = 2 points), platelet count
- Published
- 2024
149. Primary Atriopathy in Mitral Valve Prolapse: Echocardiographic Evidence and Clinical Implications.
- Author
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Tastet, Lionel, Lim, Lisa, Bibby, Dwight, Hu, Gene, Cristin, Luca, Rich, Amy, Jhawar, Rohit, Fang, Qizhi, Arya, Farzin, and Delling, Francesca
- Subjects
atrial fibrillation ,cardiovascular diseases ,echocardiography ,mitral valve prolapse ,Humans ,Mitral Valve Prolapse ,Female ,Male ,Aged ,Middle Aged ,Atrial Function ,Left ,Atrial Remodeling ,Heart Atria ,Atrial Fibrillation ,Risk Factors ,Severity of Illness Index ,Retrospective Studies ,Mitral Valve ,Echocardiography ,Mitral Valve Insufficiency ,Predictive Value of Tests - Abstract
BACKGROUND: Prominent multi-scallop systolic leaflet displacement toward the left atrium (atrialization) is typically observed in bileaflet mitral valve prolapse (MVP) with mitral annular disjunction. We hypothesized that mitral leaflet atrialization is associated with an underlying left atrial (LA) myopathy characterized by progressive structural and functional abnormalities, irrespective of mitral regurgitation (MR) severity. METHODS: We identified 334 consecutive patients with MVP, no prior atrial fibrillation, and comprehensive clinical and echocardiographic data. LA function was assessed by LA reservoir strain, LA function index, and LA emptying fraction. We also classified the stage of LA remodeling based on LA enlargement and LA reservoir strain (stage 1: no remodeling; stage 2: mild remodeling; stage 3: moderate remodeling; and stage 4: severe remodeling). The primary end point was the composite risk of sudden arrhythmic death, heart failure hospitalization, or the new onset of atrial fibrillation. RESULTS: Bileaflet MVP with no or mild MR had a lower LA reservoir strain (P=0.04) and LA function index (P
- Published
- 2024
150. Medical Students' Views on What Professionalism Means: An Ubuntu Perspective
- Author
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Mantoa Mokhachane, Lionel Green-Thompson, Ann George, Tasha Wyatt, and Ayelet Kuper
- Abstract
Medical training has become a global phenomenon, and the Physician's Charter (PC), as a missionary document, is key to training those outside the Global North. Undergraduate and postgraduate students in the medical profession are sometimes trained in contexts foreign to their social and ontological backgrounds. This might lead to confusion and blunders, creating an impression of what might look and feel unprofessional to those unfamiliar with the local context. Understanding the cultural backgrounds of the trainees is crucial, and the reverse is also as important. It is essential for clinicians and trainees to understand the cultural backgrounds of their patients to avoid miscommunication. In this phenomenological study, we recruited participants in 2020 who were in their first to fourth year of study of medical training during the #FeesMustFall protests. We used data from this extensive study looking at students' experiences during their training amidst protest and social upheavals in a South African tertiary institution. For this paper, we examined what professionalism means to the student participants using an African Ubuntu lens. Ubuntu and the Collective Finger theory were used to investigate what professionalism means to participants. The Ubuntu philosophy was compared to the PC. In the findings, the clinical space is hierarchical, silencing and the opposite of what Ubuntu means. In comparison to the PC, respect is overarching while compassion and responsibility are the most comparable to the Charter. This study adds an African voice to the professionalism discourse while showing African elements that could be aligned to the PC to challenge the current global discourses.
- Published
- 2024
- Full Text
- View/download PDF
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