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101. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

Author

Greenbaum, Adam, Hsu, Yen-Michael S., Day, Ryan B., Schuettpelz, Laura G., Christopher, Matthew J., Borgerding, Joshua N., Nagasawa, Takashi, and Link, Daniel C.

Subjects
Physiological aspects, Research, Chemokines -- Physiological aspects, Genetic code -- Research, Hematopoietic stem cells -- Physiological aspects, Medical research, Ligands (Biochemistry) -- Physiological aspects, Ligand binding (Biochemistry) -- Physiological aspects, Medicine, Experimental
Abstract

CXCL12 has a crucial role in maintaining HSC function, including retention in the bone marrow (8,12-14), quiescence (15,16) and repopulating activity (16). To test the hypothesis that CXCL12 production by [...], Haematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation and trafficking. Endosteal osteoblasts (1,2) and perivascular stromal cells including endothelial cells (3), CXCL12-abundant reticular cells (4,5), leptin-receptor-positive stromal cells (6), and nestin-green fluorescent protein (GFP)-positive mesenchymal progenitors (7) have all been implicated in HSC maintenance. However, it is unclear whether specific haematopoietic progenitor cell (HPC) subsets reside in distinct niches defined by the surrounding stromal cells and the regulatory molecules they produce. CXCL12 (chemokine (C-X-C motif) ligand 12) regulates both HSCs and lymphoid progenitors and is expressed by all of these stromal cell populations (7-11). Here we selectively deleted Cxcl12 from candidate niche stromal cell populations and characterized the effect on HPCs. Deletion of Cxcl12 from mineralizing osteoblasts has no effect on HSCs or lymphoid progenitors. Deletion of Cxcl12 from osterixexpressing stromal cells, which include CXCL12-abundant reticular cells and osteoblasts, results in constitutive HPC mobilization and a loss of B-lymphoid progenitors, but HSC function is normal. Cxcl12 deletion from endothelial cells results in a modest loss of long-term repopulating activity. Strikingly, deletion of Cxcl12 from nestin-negative mesenchymal progenitors using Prx1-cre (Prx1 also known as Prrx1) is associated with a marked loss of HSCs, longterm repopulating activity, HSC quiescence and common lymphoid progenitors. These data suggest that osterix-expressing stromal cells comprise a distinct niche that supports B-lymphoid progenitors and retains HPCs in the bone marrow, and that expression of CXCL12 from stromal cells in the perivascular region, including endothelial cells and mesenchymal progenitors, supports HSCs.

Published
2013

104. Analysis of the Proteomes of Primary, De Novo Acute Myeloid Leukemia Cells from Adults

Author

Kramer, Michael H, primary, Zhang, Qiang, additional, Sprung, Robert W., additional, Erdmann-Gilmore, Petra, additional, George, Daniel R, additional, Helton, Nichole M, additional, Heath, Sharon E, additional, Payton, Jacqueline E., additional, Westervelt, Peter, additional, Miller, Christopher A, additional, Walter, Matthew J., additional, Link, Daniel C., additional, DiPersio, John F., additional, Townsend, R Reid, additional, and Ley, Timothy J, additional

Published
2021
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105. Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression

Author

Ferraro, Francesca, primary, Miller, Christopher A, additional, Christensen, Keegan A, additional, Helton, Nichole M, additional, O'Laughlin, Michelle, additional, Fulton, Robert, additional, Kohlschmidt, Jessica, additional, Eisfeld, Ann-Kathrin, additional, Clara, Bloomfield, additional, Ramakrishnan, Sai Mukund, additional, Wartman, Lukas D, additional, Welch, John, additional, Christopher, Matthew, additional, Heath, Sharon E, additional, Westervelt, Peter, additional, Baty, Jack D, additional, Payton, Jacqueline E., additional, Retting, Michael, additional, Link, Daniel C., additional, Walter, Matthew J., additional, DiPersio, John F., additional, Day, Ryan, additional, Uy, Geoffrey L., additional, Schuelke, Matthew, additional, Spencer, David H, additional, and Ley, Timothy J, additional

Published
2021
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112. Immunosuppression and Outcomes in Acute Myeloid Leukemia

Author

Ferraro, Francesca, primary, Miller, Christopher, additional, Christensen, Keegan, additional, Helton, Nichole M., additional, O'Laughlin, Margareth, additional, Fronick, Catrina C, additional, Fulton, Robert S, additional, Kohlschmidt, Jessica, additional, Eisfeld, Ann-Kathrin, additional, Bloomfield, Clara D, additional, Ramakrishnan, Sai M, additional, Day, Ryan B, additional, Wartman, Lukas D, additional, Uy, Geoffrey L, additional, Welch, John S, additional, Christopher, Matthew J, additional, Heath, Sharon E, additional, Baty, Jack D, additional, Schuelke, Matthew J, additional, Payton, Jacqueline E, additional, Spencer, David H, additional, Rettig, Michael P, additional, Link, Daniel C, additional, Walter, Matthew J, additional, Peter, Westervelt, additional, DiPersio, John F, additional, and Ley, Timothy J, additional

Published
2021
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114. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Author

Ding, Li, Ley, Timothy J., Larson, David E., Miller, Christopher A., Koboldt, Daniel C., Welch, John S., Ritchey, Julie K., Young, Margaret A., Lamprecht, Tamara, McLellan, Michael D., McMichael, Joshua F., Wallis, John W., Lu, Charles, Shen, Dong, Harris, Christopher C., Dooling, David J., Fulton, Robert S., Fulton, Lucinda L., Chen, Ken, Schmidt, Heather, Kalicki-Veizer, Joelle, Magrini, Vincent J., Cook, Lisa, McGrath, Sean D., Vickery, Tammi L., Wendl, Michael C., Heath, Sharon, Watson, Mark A., Link, Daniel C., Tomasson, Michael H., Shannon, William D., Payton, Jacqueline E., Kulkarni, Shashikant, Westervelt, Peter, Walter, Matthew J., Graubert, Timothy A., Mardis, Elaine R., Wilson, Richard K., and DiPersio, John F.

Subjects
Genetic aspects, Abnormalities, Health aspects, DNA sequencing -- Health aspects, Clonal selection (Immunology) -- Abnormalities, Acute myelocytic leukemia -- Genetic aspects, Nucleotide sequencing -- Health aspects, Clonal selection theory -- Abnormalities
Abstract

To investigate the genetic changes associated with AML relapse, and to determine whether clonal evolution contributes to relapse, we performed whole-genome sequencing of primary tumour-relapse pairs and matched skin samples [...], Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal evolution at the cytogenetic level (1,2). To determine the mutational spectrum associated with relapse, we sequenced the primary tumour and relapse genomes from eight AML patients, and validated hundreds of somatic mutations using deep sequencing; this allowed us to define clonality and clonal evolution patterns precisely at relapse. In addition to discovering novel, recurrently mutated genes (for example, WAC, SMC3, DIS3, DDX41 and DAXX) in AML, we also found two major clonal evolution patterns during AML relapse: (1) the founding clone in the primary tumour gained mutations and evolved into the relapse clone, or (2) a subclone of the founding clone survived initial therapy, gained additional mutations and expanded at relapse. In all cases, chemotherapy failed to eradicate the founding clone. The comparison of relapse-specific versus primary tumour mutations in all eight cases revealed an increase in transversions, probably due to DNA damage caused by cytotoxic chemotherapy. These data demonstrate that AML relapse is associated with the addition of new mutations and clonal evolution, which is shaped, in part, by the chemotherapy that the patients receive to establish and maintain remissions.

Published
2012
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116. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

Author

Tomasson, Michael H., Xiang, Zhifu, Walgren, Richard, Zhao, Yu, Kasai, Yumi, Miner, Tracie, Ries, Rhonda E., Lubman, Olga, Fremont, Daved H., McLellan, Michael D., Payton, Jacqueline E., Westervelt, Peter, DiPersio, John F., Link, Daniel C., Walter, Matthew J., Graubert, Timothy A., Watson, Mark, Baty, Jack, Heath, Sharon, Shannon, William D., Nagarajan, Rakesh, Bloomfield, Clara D., Mardis, Elaine R., Wilson, Richard K., and Ley, Timothy J.

Published
2008
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117. DNMT3A mutations in acute myeloid leukemia

Author

Ley, Timothy J., Li Ding, Walter, Matthew J., McLellan, Michael D., Lamprecht, Tamara, Larson, David E., Kandoth, Cyriac, Payton, Jacqueline E., Baty, Jack, Welch, John, Harris, Christopher C., Lichti, Cheryl F., Townsend, R. Reid, Fulton, Robert S., Dooling, David J., Koboldt, Daniel C., Schmidt, Heather, Qunyuan Zhang, Osborne, John R., Ling Lin, O'aughlin, Michelle, McMichael, Joshua F., Delehaunty, Kim D., McGrath, Sean D., Fulton, Lucinda A., Magrini, Vincent J., Vickery, Tammi L., Hundal, Jasreet, Cook, Lisa L., Conyers, Joshua J., Swift, Gary W., Reed, Jerry P., Alldredge, Patricia A., Wylie, Todd, Walker, Jason, Kalicki, Joelle, Watson, Mark A., Heath, Sharon, Shannon, William D., Varghese, Nobish, Nagarajan, Rakesh, Westervelt, Peter, Tomasson, Michael H., Link, Daniel C., Graubert, Timothy A., DiPersio, John F., Mardis, Elaine R., and Wilson, Richard K.

Subjects
Amino acids -- Chemical properties, Amino acids -- Health aspects, Nucleotide sequencing -- Usage
Abstract

A study was conducted to evaluate whether DNMT3A is recurrently mutated in acute myeloid leukemia samples and whether DNMT3A mutations are associated with poor survival rates. Results indicated that sNMT3A mutations are highly recurrent in such patients and are independently associated with poor outcomes.

Published
2010

118. CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

Author

Eash, Kyle J., Greenbaum, Adam M., Gopalan, Priya K., and Link, Daniel C.

Subjects
Physiological aspects, Research, Genetic aspects, Health aspects, Natural immunity -- Health aspects -- Research -- Physiological aspects, Chemokines -- Health aspects -- Genetic aspects -- Research -- Physiological aspects, Neutrophils -- Physiological aspects -- Research -- Health aspects
Abstract

Introduction Neutrophils are an essential component of the innate immune response and a major contributor to inflammation. Accordingly, the number of neutrophils in the blood is tightly regulated. Neutrophil homeostasis [...], Neutrophils are a major component of the innate immune response. Their homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal for neutrophils in the bone marrow through activation of its receptor, CXCR4. Attenuation of CXCR4 signaling leads to entry of neutrophils into the circulation through unknown mechanisms. We investigated the role of CXCR2-binding [ELR.sup.+] chemokines in neutrophil trafficking using mouse mixed bone marrow chimeras reconstituted with [Cxcr2.sup.[-/-]] and WT cells. In this context, neutrophils lacking CXCR2 were preferentially retained in the bone marrow, a phenotype resembling the congenital disorder myelokathexis, which is characterized by chronic neutropenia. Additionally, transient disruption of CXCR4 failed to mobilize [Cxcr2.sup.[-/-]] neutrophils. However, neutrophils lacking both CXCR2 and CXCR4 displayed constitutive mobilization, showing that CXCR4 plays a dominant role in neutrophil trafficking. With regard to CXCR2 ligands, bone marrow endothelial cells and osteoblasts constitutively expressed the [ELR.sup.+] chemokines CXCL1 and CXCL2, and CXCL2 expression was induced in endothelial cells during G-CSF-induced neutrophil mobilization. Collectively, these data suggest that CXCR2 signaling is a second chemokine axis that interacts antagonistically with CXCR4 to regulate neutrophil release from the bone marrow.

Published
2010
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120. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

Author

Payton, Jacqueline E., Grieselhuber, Nicole R., Chang, Li-Wei, Murakami, Mark, Geiss, Gary K., Link, Daniel C., Nagarajan, Rakesh, Watson, Mark A., and Ley, Timothy J.

Subjects
Physiological aspects, Measurement, Research, Genetic aspects, Gene expression -- Research -- Measurement -- Physiological aspects -- Genetic aspects, Messenger RNA -- Measurement -- Physiological aspects -- Research -- Genetic aspects, Acute myelocytic leukemia -- Genetic aspects -- Research
Abstract

Introduction Here we describe what is, to our knowledge, the first use of a high-throughput digital system to assay the expression of a large number of genes in primary clinical [...], Acute promyelocytic leukemia (APL) is characterized by the t(15;17) chromosomal translocation, which results in fusion of the retinoic acid receptor α (RARA) gene to another gene, most commonly promyelocytic leukemia (PML). The resulting fusion protein, PML-RARA, initiates APL, which is a subtype (M3) of acute myeloid leukemia (AML). In this report, we identify a gene expression signature that is specific to M3 samples; it was not found in other AML subtypes and did not simply represent the normal gene expression pattern of primary promyelocytes. To validate this signature for a large number of genes, we tested a recently developed high throughput digital technology (NanoString nCounter). Nearly all of the genes tested demonstrated highly significant concordance with our microarray data (P < 0.05). The validated gene signature reliably identified M3 samples in 2 other AML datasets, and the validated genes were substantially enriched in our mouse model of APL, but not in a cell line that inducibly expressed PML-RARA. These results demonstrate that nCounter is a highly reproducible, customizable system for mRNA quantification using limited amounts of clinical material, which provides a valuable tool for biomarker measurement in low-abundance patient samples.

Published
2009

121. Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia

Author

Petti, Allegra A., primary, Khan, Saad M., additional, Xu, Ziheng, additional, Helton, Nichole, additional, Fronick, Catrina C., additional, Fulton, Robert, additional, Ramakrishnan, Sai M., additional, Nonavinkere Srivatsan, Sridhar, additional, Heath, Sharon E., additional, Westervelt, Peter, additional, Payton, Jacqueline E., additional, Walter, Matthew J., additional, Link, Daniel C., additional, DiPersio, John, additional, Miller, Christopher, additional, and Ley, Timothy J., additional

Published
2021
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122. Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, additional, Nonavinkere Srivatsan, Sridhar, additional, Ahmed, Tanzir, additional, Chen, Yuhao, additional, Lemacon, Delphine S., additional, Li, Ying, additional, Yang, Zheng, additional, Wadugu, Brian A., additional, Warner, Wayne A., additional, Pruett-Miller, Shondra M., additional, Obeng, Esther A., additional, Link, Daniel C., additional, He, Dalin, additional, Xiao, Fei, additional, Wang, Xiaowei, additional, Bailis, Julie M., additional, Walter, Matthew J., additional, and You, Zhongsheng, additional

Published
2021
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123. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Author

Ley, Timothy J., Mardis, Elaine R., Ding, Li, Fulton, Bob, McLellan, Michael D., Chen, Ken, Dooling, David, Dunford-Shore, Brian H., McGrath, Sean, Hickenbotham, Matthew, Cook, Lisa, Abbott, Rachel, Larson, David E., Koboldt, Dan C., Pohl, Craig, Smith, Scott, Hawkins, Amy, Abbott, Scott, Locke, Devin, Hillier, LaDeana W., Miner, Tracie, Fulton, Lucinda, Magrini, Vincent, Wylie, Todd, Glasscock, Jarret, Conyers, Joshua, Sander, Nathan, Shi, Xiaoqi, Osborne, John R., Minx, Patrick, Gordon, David, Chinwalla, Asif, Zhao, Yu, Ries, Rhonda E., Payton, Jacqueline E., Westervelt, Peter, Tomasson, Michael H., Watson, Mark, Baty, Jack, Ivanovich, Jennifer, Heath, Sharon, Shannon, William D., Nagarajan, Rakesh, Walter, Matthew J., Link, Daniel C., Graubert, Timothy A., DiPersio, John F., and Wilson, Richard K.

Subjects
Care and treatment, Genetic aspects, Health aspects, DNA sequencing -- Health aspects -- Genetic aspects, Leukemia -- Care and treatment -- Genetic aspects, Nucleotide sequencing -- Health aspects -- Genetic aspects
Abstract

Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about 13,000 adults in the United States each year. The treatment of this disease has changed little in the [...]

Published
2008

124. Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5

Author

Liu, Fulu, Kunter, Ghada, Krem, Maxwell M., Eades, William C., Cain, Jennifer A., Tomasson, Michael H., Hennighausen, Lothar, and Link, Daniel C.

Subjects
Complications and side effects, Research, Genetic aspects, Health aspects, Gene mutation -- Complications and side effects -- Research -- Health aspects -- Genetic aspects, Stem cells -- Health aspects -- Genetic aspects -- Research, Gene expression -- Research -- Genetic aspects -- Health aspects, Gene mutations -- Complications and side effects -- Research -- Health aspects -- Genetic aspects
Abstract

Introduction There is accumulating evidence suggesting that most leukemia is initiated by rare cancer stem cells, referred to as leukemic stem cells (LSCs). LSCs are functionally defined as cells able [...], A fundamental property of leukemic stem cells is clonal dominance of the bone marrow microenvironment. Truncation mutations of CSF3R, which encodes the G-CSF receptor (G-CSFR), are implicated in leukemic progression in patients with severe congenital neutropenia. Here we show that expression of a truncated mutant Csf3r in mice confers a strong clonal advantage at the HSC level that is dependent upon exogenous G-CSF. G-CSF--induced proliferation, phosphorylation of Stat5, and transcription of Stat5 target genes were increased in HSCs isolated from mice expressing the mutant Csf3r. Conversely, the proliferative advantage conferred by the mutant Csf3r was abrogated in myeloid progenitors lacking both Stat5A and Stat5B, and HSC function was reduced in mice expressing a truncated mutant Csf3r engineered to have impaired Stat5 activation. These data indicate that in mice, inappropriate Stat5 activation plays a key role in establishing clonal dominance by stem cells expressing mutant Csf3r.

Published
2008

126. Impact of PARP Inhibitor and Platinum Therapy on Clonal Hematopoiesis

Author

Baeten, Jeremy T., Chan, Irenaeus C.C., Moukarzel, Lea, Carter, Amber C., Patel, Minal, Stopsack, Konrad H., Pharoah, Paul, Brenton, James, Li, Bob T, Abida, Wassim, Schram, Alison M., Cadoo, Karen, Weigelt, Britta, Cruchaga, Carlos, Scher, Howard, Levine, Ross L, Papaemmanuil, Elli, Link, Daniel C., and Bolton, Kelly L.

Published
2023
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131. Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

Author

Link, Daniel C., Kunter, Ghada, Kasai, Yumi, Zhao, Yu, Miner, Tracie, McLellan, Michael D., Ries, Rhonda E., Kapur, Deepak, Nagarajan, Rakesh, Dale, David C., Bolyard, Audrey Anna, Boxer, Laurence A., Welte, Karl, Zeidler, Cornelia, Donadieu, Jean, Bellanné-Chantelot, Christine, Vardiman, James W., Caligiuri, Michael A., Bloomfield, Clara D., DiPersio, John F., Tomasson, Michael H., Graubert, Timothy A., Westervelt, Peter, Watson, Mark, Shannon, William, Baty, Jack, Mardis, Elaine R., Wilson, Richard K., and Ley, Timothy J.

Published
2007
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136. Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

Author

Cheruiyot, Abigael, primary, Li, Shan, additional, Srivatsan, Sridhar Nonavinkere, additional, Ahmed, Tanzir, additional, Chen, Yuhao, additional, Lemacon, Delphine Sangotokun, additional, Li, Ying, additional, Yang, Zheng, additional, Wadugu, Brian A., additional, Warner, Wayne, additional, Pruett-Miller, Shondra M., additional, Obeng, Esther A., additional, Link, Daniel C., additional, He, Dalin, additional, Xiao, Fei, additional, Wang, Xiaowei, additional, Bailis, Julie M., additional, Walter, Matthew J., additional, and You, Zhongsheng, additional

Published
2021
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137. Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers

Author

Duncavage, Eric J., primary, Schroeder, Molly C., additional, O’Laughlin, Michele, additional, Wilson, Roxanne, additional, MacMillan, Sandra, additional, Bohannon, Andrew, additional, Kruchowski, Scott, additional, Garza, John, additional, Du, Feiyu, additional, Hughes, Andrew E.O., additional, Robinson, Josh, additional, Hughes, Emma, additional, Heath, Sharon E., additional, Baty, Jack D., additional, Neidich, Julie, additional, Christopher, Matthew J., additional, Jacoby, Meagan A., additional, Uy, Geoffrey L., additional, Fulton, Robert S., additional, Miller, Christopher A., additional, Payton, Jacqueline E., additional, Link, Daniel C., additional, Walter, Matthew J., additional, Westervelt, Peter, additional, DiPersio, John F., additional, Ley, Timothy J., additional, and Spencer, David H., additional

Published
2021
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138. Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

Author

Wilson, Elisabeth R., primary, Helton, Nichole M., additional, Heath, Sharon E., additional, Fulton, Robert S., additional, Payton, Jacqueline E., additional, Welch, John S., additional, Walter, Matthew J., additional, Westervelt, Peter, additional, DiPersio, John F., additional, Link, Daniel C., additional, Miller, Christopher A., additional, Ley, Timothy J., additional, and Spencer, David H., additional

Published
2021
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147. Spondyloepiphyseal Dysplasia

Author

Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional

Published
2009
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148. Stress-induced Tachycardia

Author

Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional

Published
2009
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149. Sarcoidosis (Lung)

Author

Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional

Published
2009
Full Text
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150. Stress and Cardiovascular Risk

Author

Leung, Alexander K. C., primary, Kao, Cham Pion, additional, Wong, Andrew L., additional, Leung, Alexander K. C., additional, Kolter, Thomas, additional, Schepers, Ute, additional, Sandhoff, Konrad, additional, Myers, Bennett, additional, Herrmann, David N., additional, Mahajan, Vikram K., additional, Sharma, Nand Lal, additional, Kashyap, Surender, additional, Scott, C. Ronald, additional, Gall, Natalie, additional, Welt, Katrin, additional, Scharffetter-Kochanek, Karin, additional, Harries, Matthew, additional, Fischer, Tobias, additional, Paus, Ralf, additional, Boerkoel, Cornelius F., additional, Elizondo, Leah I., additional, Lücke, Thomas, additional, Nöthen, Markus M., additional, Rietschel, Marcella, additional, Lang, Undine E., additional, Nicole, Sophie, additional, Fontaine, Bertrand, additional, Robson, William Lane M., additional, Krieg, Thomas, additional, Weihrauch, Julia, additional, Jimenez, Sergio A., additional, Cate, Hugo Ten, additional, Zusman, Itshak, additional, Gurevich, Pavel, additional, Ben-Hur, Herzl, additional, Keller, Jutta, additional, Litzman, Jiri, additional, Zhao, Yaofeng, additional, Hammarstöm, Lennart, additional, Bergomi, Margherita, additional, Malagoli, Carlotta, additional, Vinceti, Marco, additional, Dupont, Marie-Estelle, additional, Guilbaud, Olivier, additional, Gröne, Hermann-Josef, additional, Popovic, Zoran V., additional, Mancini, Mario, additional, Davidovici, Batya B., additional, Marcos, Batsheva, additional, Orion, Edith, additional, Wolf, Ronni, additional, Vincent, Jean-Louis, additional, Feuerstein, Giora Z., additional, Keith, James C., additional, Ruffolo, Robert R., additional, Sunderkötter, Cord, additional, Naki, M. Murat, additional, Tekcan, Cevahir, additional, Rawls, Amy S., additional, Link, Daniel C., additional, Reitzenstein, Carolina, additional, Kopitz, Jürgen, additional, Cantz, Michael, additional, Uhl, Johannes, additional, Schnog, John-John B., additional, Gerdes, Victor E. A., additional, Schütte, Bärbel, additional, Arbes, Samuel J., additional, Zeldin, Darryl C., additional, Baumer, Alessandra, additional, Zenner, Hans-Peter, additional, Harvey, Brandy J., additional, Lee, Jyh-Yeuan, additional, Urbatsch, Ina L., additional, Rémi, Jan, additional, Noachtar, Soheyl, additional, Elsea, Sarah H., additional, Girirajan, Santhosh, additional, Toh, Chee-Keong, additional, Schüle, Rebecca, additional, Schöls, Ludger, additional, Borregaard, Niels, additional, Cowland, Jack B., additional, Mitchell, Laura E., additional, Etheredge, Analee J., additional, Hill, Denise S., additional, Finnell, Richard H., additional, Schiller, Meinhard, additional, Nashan, Dorothee, additional, Reuter, Stefan, additional, Geneviève, David, additional, Cormier-Daire, Valérie, additional, Gécz, Jozef, additional, Savarirayan, Ravi, additional, Loir, Yves Le, additional, Gautier, Michel, additional, Rozet, Jean-Michel, additional, Kaplan, Josseline, additional, Lukasiuk, Katarzyna, additional, Pitkänen, Asla, additional, Haas, Stephan, additional, Siegmund, Sören, additional, Singer, Manfred V., additional, Dancygier, Henryk, additional, Oette, Mark, additional, Andrés, Vicente, additional, Wessely, Rainer, additional, Merke, Deborah P., additional, Ellis Hon, Kam-Lun, additional, Engel, Jutta, additional, Meinck, Hans-Michael, additional, Ludwig, Amei, additional, Hengel, Hartmut, additional, Wang, Xinkang, additional, Gerber, Ivor L., additional, Sibley, Eric, additional, Takatsu, Akihiro, additional, Bondy, Brigitta, additional, Markovich, Daniel, additional, Huang, Ting-Ting, additional, Epstein, Charles J., additional, and Prange, Hilmar, additional

Published
2009
Full Text
View/download PDF

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