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A 2.9 V intrinsic safe aqueous LiNi0.5Mn1.5O4/Mo6S8 full cell delivers 80 W h kg−1 energy density with capacity decay of 0.075% per cycle (5 C). After the electrolyte pH value adjustment, almost full capacity of LiNi0.5Mn1.5O4 (125 mA h kg−1) is achieved, and 126 W h kg−1 energy density is provided for LiNi0.5Mn1.5O4/Mo6S8 cell, representing one of the highest voltage and energy density among all the aqueous batteries. [ABSTRACT FROM AUTHOR]

Cu-Sn binary particles were generated via spray pyrolysis from metal salt precursors with ethylene glycol as the co-solvent and reducing agent. The morphology, crystallinity, and elemental distribution of particles were tunable by changing the reaction temperature, residence time, and quench gas flow rate. Hollow porous particles were fabricated with a higher Sn concentration on the particle surface when the furnace set point was 500°C, while solid particles with a lower surface Sn concentration were generated when the furnace set point was 1000°C. Particles with spherical morphologies were obtained at long residence time conditions (4.5 s). Cu-Sn binary particles with irregular structures (e.g., pores on the particle surface, fragmented spherical particles, and lamellar fragments) were formed at short residence time conditions (0.92 s). A possible spray pyrolysis mechanism was proposed that incorporates chemical reaction steps and structural progression. By this mechanism, the metal salts are believed to sequentially undergo hydrolysis to metal hydroxides, decomposition to metal oxides, reduction to metals, and finally diffusion of Sn into the Cu matrix to generate the Cu-Sn solid solution. Copyright © 2017 American Association for Aerosol Research [ABSTRACT FROM PUBLISHER]

The wide applications of rechargeable batteries require state‐of‐the‐art batteries that are sustainable (abundant resource), tolerant to high‐temperature operations, and excellent in delivering high capacity and long‐term cycling life. Due to the scarcity and uneven distribution of lithium, it is urgent to develop alternative rechargeable batteries. Herein, an organic compound, azobenzene‐4,4′‐dicarboxylic acid potassium salts (ADAPTS) is developed, with an azo group as the redox center for high performance potassium‐ion batteries (KIBs). The extended π‐conjugated structure in ADAPTS and surface reactions between ADAPTS and K‐ions enable the stable charge/discharge of K‐ion batteries even at high temperatures up to 60 °C. When operated at 50 °C, ADAPTS anode delivers a reversible capacity of 109 mAh g−1 at 1C for 400 cycles. A reversible capacity of 77 mAh g−1 is retained at 2C for 1000 cycles. At 60 °C, the ADAPTS‐based KIBs deliver a high capacity of 113 mAh g−1 with 81% capacity retention at 2C after 80 cycles. The exceptional electrochemical performance demonstrates that ADAPTS is a promising electrode material for high‐temperature KIBs. An organic anode based on an azo group as the redox center is designed and synthesized for high temperature potassium‐ion batteries. The surface reaction‐controlled mechanism between the azo compound and K‐ions enables superior electrochemical performance of K‐ion batteries with an operating temperature up to 60 °C. [ABSTRACT FROM AUTHOR]

Hybridizing Pd-based electrocatalysts with Ni-based species has been recognized as an effective pathway to enhance the catalytic performance for the methanol oxidation reaction (MOR). However, doping Ni-based species with heterogeneous valences into Pd nanocrystals still remains challenging, although heterogeneous valence Ni species may result in improved properties of Pd from different aspects. Herein, a facile one-pot synthetic method is reported to simultaneously introduce alloyed Ni 0 into Pd lattices and couple hydroxy Ni 2+ species with a Pd surface, generating 1D porous PdNi alloy nanochains@Ni(OH) 2 nanosheet hybrids (PdNi NCs@Ni(OH) 2 NSs). Borane- tert -butylamine (C 4 H 14 BN) plays the key role in realizing the formation of Ni-based species with heterogeneous valence. On one hand, it works as a reducing agent to facilitate the doping of alloyed Ni 0 into the lattice of Pd nanochains. On the other hand, it raises the solution pH value and converts the remaining [Ni(CN) 4 ] 2- into Ni(OH) 2 nanosheets. Each component of the PdNi NCs@Ni(OH) 2 NSs plays an important role: Pd serves as the active site, alloyed Ni 0 modifies the electronic structure of Pd, and Ni(OH) 2 provides abundant OH ads species to strengthen the anti-poisoning capability, thus greatly enhancing the activity, CO-tolerance, and durability for the MOR.

Introduction: Reactive oxygen species (ROS)-mediated therapies have typically been considered as noninvasive tumor treatments owing to their high selectivity and efficiency. However, the harsh tumor microenvironment severely impairs their efficiency. Methods: Herein, the biodegradable Cu-doped zeolitic imidazolate framework-8 (ZIF-8) was synthesized for loading photosensitizer Chlorin e6 (Ce6) and CaO 2 nanoparticles, followed by surface decoration by hyaluronic acid (HA), obtaining HA/CaO 2 -Ce6@Cu-ZIF nano platform. Results and Discussion: Once HA/CaO 2 -Ce6@Cu-ZIF targets tumor sites, the degradation of Ce6 and CaO 2 release from the HA/CaO 2 -Ce6@Cu-ZIF in response to the acid environment, while the Cu 2+ active sites on Cu-ZIF are exposed. The released CaO 2 decompose to generate hydrogen peroxide (H 2 O 2 ) and oxygen (O 2 ), which alleviate the insufficiency of intracellular H 2 O 2 and hypoxia in tumor microenvironment (TME), effectively enhancing the production of hydroxyl radical (•OH) and singlet oxygen ( 1 O 2 ) in Cu 2+ -mediated chemodynamic therapy (CDT) and Ce6-induced photodynamic therapy (PDT), respectively. Importantly, Ca 2+ originating from CaO 2 could further enhance oxidative stress and result in mitochondrial dysfunction induced by Ca 2+ overloading. Conclusion: Thus, the H 2 O 2 /O 2 self-supplying and Ca 2+ overloading ZIF-based nanoplatform for cascade-amplified CDT/PDT synergistic strategy is promising for highly efficient anticancer therapy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Liang, Cai, Tang, Su, Xie, Li and Liang.)

Plumbagin (PL) pharmacologically plays the anti-proliferative effects in cancer cells, including effective suppression of colorectal cancer (CRC). However, the exact molecular mechanism of PL to treat CRC remains unclear. Using available SwissTargetPrediction and SuperPred databases, the anti-cancer biotargets of PL were identified, and the CRC-diseased targets were obtained through a DisGeNET database. The biological processes, and signaling pathways of PL to treat CRC were identified and visualized. Further, clinical and cell culture data were used to validate some bioinformatic findings. As shown in bioinformatics findings, 64 predictive biotargets of PL to treat CRC were collected, and 7 most important biotargets of tumor protein p53 (TP53), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), mitogen-activated protein kinase 1 (MAPK1), E1A-associated protein p300 (EP300), poly (ADP-ribose) polymerase 1 (PARP1), nuclear factor kappa p65 protein (RELA), Bcl-2 like protein 1 (BCL2L1) were identified respectively. In addition, top 20 functional biological processes, signaling pathways of PL to treat CRC were screened and prioritized. In human study, CRC samples showed elevated expressions of neoplastic MAPK1, PARP1 mRNAs and reduced EP300 mRNA level. In cell culture study, PL-treated CRC cells resulted in down-regulated MAPK1, PARP1 mRNA expressions and up-regulation of EP300 mRNA level, characterized with suppressed cell proliferation. Taken together, the therapeutic biotargets and molecular mechanisms of PL to treat CRC were screened and identified by using a systematic pharmacology analysis, and some bioinformatic findings were validated in clinical and cell line experiments. Potentially, these hub biotargets may be the biomarkers for CRC detection and treatment., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Objective: To observe change of iliac artery SMC collagen fiber after balloon injury in tanshinone II A treatment group., Methods: Thirty male pure breed New Zealand white rabbits were underwent experimental balloon injury in left iliac artery. Then the rabbits were assigned into treatment group (n = 15) and control group (n = 15). Tanshinone II A sulfonic acid natrium was injected intravenously in treatment group. Saline was venously injected in control group. The balloon injured arteries were harvested in the 7th, 14th, and 28th days after surgery., Results: Analysis of Collagen fibers staining found that a weak positive staining was shown at the 7th day post-operation in both groups,while a strong positive result was seen at the 14th day in control group. Positive results were even shown at the 14th day in treatment group,but less strong than that of the control. At the 28th day post-operation, collagen fiber staining become weak in treatment group, but increased in the control. Difference between both group in the 28th day post-operation was significant (P = 0.017). Time-dependence tendency of collagen fiber changing was statistically significant (P = 0.005)., Conclusion: Tanshinone II A suppress stack of extracellular matrix after balloon injury so as to prevent restenosis.