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10,222 results on '"Liang, W."'

103. Development of a serum-based miRNA signature for early detection of pancreatic cancer: a multicenter cohort study

Author

Huang, Jing, primary, Gao, Ge, additional, Liu, Jianzhou, additional, Ge, Yang, additional, Cui, Hongtu, additional, Zheng, Ren, additional, Wang, Jialin, additional, Wang, Si, additional, Go, Vay Liang (W), additional, Hu, Shen, additional, Liu, Yefu, additional, Yang, Minwei, additional, Sun, Yongwei, additional, Shang, Dong, additional, Tian, Yantao, additional, Zhang, Zhigang, additional, Xiang, Zhongyuan, additional, Guo, Junchao, additional, Wang, Hongyang, additional, and Xiao, Gary Guishan, additional

Published
2023
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107. Linear scaling calculation of maximally-localized Wannier functions with atomic basis set

Author

Xiang, H. J., Li, Zhenyu, Liang, W. Z., Yang, Jinlong, Hou, J. G., and Zhu, Qingshi

Subjects
Condensed Matter - Materials Science
Abstract

We have developed a linear scaling algorithm for calculating maximally-localized Wannier functions (MLWFs) using atomic orbital basis. An O(N) ground state calculation is carried out to get the density matrix (DM). Through a projection of the DM onto atomic orbitals and a subsequent O(N) orthogonalization, we obtain initial orthogonal localized orbitals. These orbitals can be maximally localized in linear scaling by simple Jacobi sweeps. Our O(N) method is validated by applying it to water molecule and wurtzite ZnO. The linear scaling behavior of the new method is demonstrated by computing the MLWFs of boron nitride nanotubes., Comment: J. Chem. Phys. in press (2006)

Published
2006
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108. Metabolic Regulation in Mitochondria and Drug Resistance

Author

Pan, Yue, Cao, Min, Liu, Jianzhou, Yang, Qing, Miao, Xiaoyu, Go, Vay Liang W., Lee, Paul W. N., Xiao, Gary Guishan, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, REZAEI, NIMA, Series editor, Sun, Hongzhi, editor, and Wang, Xiangdong, editor

Published
2017
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109. Spin unrestricted linear scaling electronic structure theory and its application to magnetic carbon doped BN nanotubes

Author

Xiang, H. J., Liang, W. Z., Yang, Jinlong, Hou, J. G., and Zhu, Qingshi

Subjects
Condensed Matter - Materials Science
Abstract

We present an extension of density matrix based linear scaling electronic structure theory to incorporate spin degrees of freedom. When the spin multiplicity of the system can be predetermined, the generalization of the existing linear scaling methods to spin unrestricted cases is straightforward. However, without calculations it is hard to determine the spin multiplicity of some complex systems, such as, many magnetic nanostuctures, some inorganic or bioinorganic molecules. Here we give a general prescription to obtain the spin-unrestricted ground state of open shell systems. Our methods are implemented into the linear scaling trace-correcting density matrix purification algorithm. The numerical atomic orbital basis, rather than the commonly adopted Gaussian basis functions is used. The test systems include O2 molecule, and magnetic carbon doped BN(5,5) and BN(7,6) nanotubes. Using the newly developed method, we find the magnetic moments in carbon doped BN nanotubes couple antiferromagnetically with each other. Our results suggest that the linear scaling spin-unrestricted trace-correcting purification method is very powerful to treat large magnetic systems., Comment: 9 pages 4 figures, to appear in The Journal of Chemical Physics

Published
2005
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110. Breakdown of the Wiedemann-Franz law in strongly-coupled electron-phonon system, application to the cuprates

Author

Lee, K. K., Alexandrov, A. S., and Liang, W. Y.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

With the superconducting cuprates in mind, a set of unitary transformations was used to decouple electrons and phonons in the strong-coupling limit. While phonons remain almost unrenormalised, electrons are transformed into itinerent singlet and triplet bipolarons and thermally excited polarons. The triplet/singlet exchange energy and the binding energy of the bipolarons are thought to account for the spin and charge pseudogaps in the cuprates, respectively. We calculated the Hall Lorenz number of the system to show that the Wiedemann-Franz law breaks down due to the interference of the polaron and bipolaron contributions to heat flow. The model provides a quantitative fit to magnetotransport data in the cuprates. Furthermore we are able to extract the phonon component of the thermal conductivity with the use of experimental data and the model. Our results further validate the use of a charged Bose gas model to describe normal and superconducting properties of unconventional superconductors., Comment: 9 pages, 6 figures. Submitted to Physical Review B

Published
2003
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111. Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population

Author

Lê, Kim-Anne, Li, Yan, Xu, Xiaojing, Yang, Wanting, Liu, Tingting, Zhao, Xiaoning, Tang, Yongming Gorge, Cai, Dehong, Go, Vay Liang W, Pandol, Stephen, and Hui, Hongxiang

Subjects
Microbiology, Biological Sciences, Biomedical and Clinical Sciences, Nutrition, Diabetes, Digestive Diseases, Obesity, Clinical Research, Prevention, Metabolic and endocrine, microbiota, microflora, metabolic diseases, gut, Physiology, Medical Physiology, Psychology, Biochemistry and cell biology, Medical physiology
Abstract

BackgroundThe connection between gut microbiota and metabolism and its role in the pathogenesis of diabetes are increasingly recognized. The objective of this study was to quantitatively measure Bifidobacterium and Lactobacillus species, members of commensal bacteria found in human gut, in type 2 diabetic patients (T2D) patients from Southern China.MethodsFifty patients with T2D and thirty control individuals of similar body mass index (BMI) were recruited from Southern China. T2D and control subjects were confirmed with both oral glucose tolerance test (OGTT) and HbA(1c) measurements. Bifidobacterium and Lactobacillus species in feces were measured by real-time quantitative PCR. Data were analyzed with STATA 11.0 statistical software.ResultsIn comparison to control subjects T2D patients had significantly more total Lactobacillus (+18%), L. bugaricus (+13%), L. rhamnosum (+37%) and L. acidophilus (+48%) (P < 0.05). In contrast, T2D patients had less amounts of total Bifidobacteria (-7%) and B. adolescentis (-12%) (P < 0.05). Cluster analysis showed that gut microbiota pattern of T2D patients is characterized by greater numbers of L. rhamnosus and L. acidophillus, together with lesser numbers of B. adolescentis (P < 0.05).ConclusionThe gut microflora in T2D patients is characterized by greater numbers of Lactobacillus and lesser numbers of Bifidobacterium species.

Published
2013

112. Absence of gross inhomogeneity in HTS cuprates

Author

Loram, J. W., Tallon, J. L., and Liang, W. Y.

Subjects
Condensed Matter - Superconductivity
Abstract

Recent scanning tunnelling microscopy (STM) studies on Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ (Bi-2212) revealed the presence of severe inhomogeneity with length scale $L_0 \approx \xi_0$, the coherence length. Other studies have been interpreted in terms of mesoscale or nanoscale phase segregation. Here we analyze heat capacity and NMR data on Bi-2212 and (Y,Ca)Ba$_2$Cu$_3$O$_{7-\delta}$ and find no evidence for phase segregation or gross inhomogeneity. For Bi-2212 the coherence scale $L_0$ increases with doping from 5 to 17$\xi_0$ and the hole density inhomogeneity decreases from 0.028 to 0.005 holes/Cu. We conclude that STM measurements considerably overstate the inhomogeneity in bulk Bi-2212., Comment: 4 pages, 5 figures, submitted to Phys. Rev. Letters

Published
2002
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113. Lorenz number in high Tc superconductors: evidence for bipolarons

Author

Lee, K. K., Alexandrov, A. S., and Liang, W. Y.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

Strong electron-phonon interaction in cuprates has gathered support over the last decade in a number of experiments. While phonons remain almost unrenormalised, electrons are transformed into itinerent bipolarons and thermally excited polarons when the electron-phonon interaction is strong. We calculate the Lorenz number of the system to show that the Wiedemann-Franz law breaks down because of the interference of polaron and bipolaron contributions in the heat flow. The model fits numerically the experimental Hall Lorenz number, which provides a direct evidence for bipolarons in the cuprates., Comment: 4 page, 1 figure

Published
2002
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114. Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population.

Author

Lê, Kim-Anne, Li, Yan, Xu, Xiaojing, Yang, Wanting, Liu, Tingting, Zhao, Xiaoning, Tang, Yongming Gorge, Cai, Dehong, Go, Vay Liang W, Pandol, Stephen, and Hui, Hongxiang

Subjects
gut, metabolic diseases, microbiota, microflora, Physiology, Medical Physiology, Psychology
Abstract

BackgroundThe connection between gut microbiota and metabolism and its role in the pathogenesis of diabetes are increasingly recognized. The objective of this study was to quantitatively measure Bifidobacterium and Lactobacillus species, members of commensal bacteria found in human gut, in type 2 diabetic patients (T2D) patients from Southern China.MethodsFifty patients with T2D and thirty control individuals of similar body mass index (BMI) were recruited from Southern China. T2D and control subjects were confirmed with both oral glucose tolerance test (OGTT) and HbA(1c) measurements. Bifidobacterium and Lactobacillus species in feces were measured by real-time quantitative PCR. Data were analyzed with STATA 11.0 statistical software.ResultsIn comparison to control subjects T2D patients had significantly more total Lactobacillus (+18%), L. bugaricus (+13%), L. rhamnosum (+37%) and L. acidophilus (+48%) (P < 0.05). In contrast, T2D patients had less amounts of total Bifidobacteria (-7%) and B. adolescentis (-12%) (P < 0.05). Cluster analysis showed that gut microbiota pattern of T2D patients is characterized by greater numbers of L. rhamnosus and L. acidophillus, together with lesser numbers of B. adolescentis (P < 0.05).ConclusionThe gut microflora in T2D patients is characterized by greater numbers of Lactobacillus and lesser numbers of Bifidobacterium species.

Published
2012

116. Membrane proteomic analysis of pancreatic cancer cells

Author

Liu, Xiaojun, Zhang, Min, Go, Vay Liang W, and Hu, Shen

Abstract

Abstract Background Pancreatic cancer is one of the most aggressive human tumors due to its high potential of local invasion and metastasis. The aim of this study was to characterize the membrane proteomes of pancreatic ductal adenocarcinoma (PDAC) cells of primary and metastatic origins, and to identify potential target proteins related to metastasis of pancreatic cancer. Methods Membrane/membrane-associated proteins were isolated from AsPC-1 and BxPC-3 cells and identified with a proteomic approach based on SDS-PAGE, in-gel tryptic digestion and liquid chromatography with tandem mass spectrometry (LC-MS/MS). X! Tandem was used for database searching against the SwissProt human protein database. Results We identified 221 & 208 proteins from AsPC-1 and BxPC-3 cells, respectively, most of which are membrane or membrane-associated proteins. A hundred and nine proteins were found in both cell lines while the others were present in either AsPC-1 or BxPC-3 cells. Differentially expressed proteins between two cell lines include modulators of cell adhesion, cell motility or tumor invasion as well as metabolic enzymes involved in glycolysis, tricarboxylic acid cycle, or nucleotide/lipid metabolism. Conclusion Membrane proteomes of AsPC-1 (metastatic) and BxPC-3 (primary) cells are remarkably different. The differentially expressed membrane proteins may serve as potential targets for diagnostic and therapeutic interventions.

Published
2010

124. Tracing erosion patterns in South Tibet: Balancing sediment supply to the Yarlung Tsangpo from the Himalaya versus Lhasa Block

Author

Liang, W, Garzanti, E, Hu, X, Resentini, A, Vezzoli, G, Yao, W, Liang W., Garzanti E., Hu X., Resentini A., Vezzoli G., Yao W., Liang, W, Garzanti, E, Hu, X, Resentini, A, Vezzoli, G, Yao, W, Liang W., Garzanti E., Hu X., Resentini A., Vezzoli G., and Yao W.

Abstract

The Yarlung Tsangpo, draining the Himalayan-Tibetan orogen along the Indus-Yarlung suture zone, receives detritus from the deformed remnants of both Indian margin to the south and Asian margin to the north. High resolution petrographic, heavy-mineral and geochemical datasets, combined with published geochronological data, allow us to monitor compositional changes, estimate erosion rates and investigate lithologic, climatic and anthropic controls on sediment fluxes along this large sediment-routing system entirely developed within high mountain areas. Sediment generated from the Lhasa Block along the southern margin of Asia is characterized by abundant feldspar and volcanic rock fragments, amphibole-dominated transparent heavy mineral suite and high concentrations of K, Rb, Be, Th and Pb. Himalayan-derived sand, instead, is characterized by sedimentary to low-rank metasedimentary rock fragments, poor transparent heavy mineral suite dominated by durable recycled (zircon, tourmaline) or metamorphic minerals (chloritoid, garnet) and high Ca concentration. Sand from the ophiolitic suture is distinguished by serpentinite grains and mafic volcanic or metavolcanic detritus, transparent heavy mineral suite including olivine, Cr-spinel, enstatite and clinopyroxene, and high Mg, Cr, Ni and low rare earth elements. Himalayan detritus is prominent in Yarlung Tsangpo upper reaches, whereas detritus from the Lhasa Block becomes progressively predominant in the middle and lower reaches. Provenance budgets based on integrated petrographic, heavy-mineral and geochemical datasets indicate that ca. 83% of the detritus is supplied by the Lhasa Block and the rest mostly from the Himalaya (ca. 12%) and subordinately from the ophiolitic suture (5%). A low average erosion rate of ca. 0.06 mm/a was estimated for the Yarlung Tsangpo catchment upstream of the Namche Barwa syntaxis, which resulted from dry climate, relatively mild average relief and sediment storage in wide valley tracts o

Published
2022

132. Active Perception for Visual-Language Navigation

Author

Wang, H, Wang, W, Liang, W, Hoi, SCH, Shen, J, Gool, LV, Wang, H, Wang, W, Liang, W, Hoi, SCH, Shen, J, and Gool, LV

Abstract

Visual-language navigation (VLN) is the task of entailing an agent to carry out navigational instructions inside photo-realistic environments. One of the key challenges in VLN is how to conduct robust navigation by mitigating the uncertainty caused by ambiguous instructions and insufficient observation of the environment. Agents trained by current approaches typically suffer from this and would consequently struggle to take navigation actions at every step. In contrast, when humans face such a challenge, we can still maintain robust navigation by actively exploring the surroundings to gather more information and thus make a more confident navigation decision. This work draws inspiration from human navigation behavior and endows an agent with an active perception ability for more intelligent navigation. To achieve this, we propose an end-to-end framework for learning an exploration policy that decides (i) when and where to explore, (ii) what information is worth gathering during exploration, and (iii) how to adjust the navigation decision after the exploration. In this way, the agent is able to turn its past experiences as well as new explored knowledge to contexts for more confident navigation decision making. In addition, an external memory is used to explicitly store the visited visual environments and thus allows the agent to adopt a late action-taking strategy to avoid duplicate exploration and navigation movements. Our experimental results on two standard benchmark datasets show promising exploration strategies emerged from training, which leads to significant boost in navigation performance.

Published
2023

134. Tissue‐specific genotype–phenotype correlations among USH2A‐related disorders in the RUSH2A study

Author

Hufnagel, R.B., Liang, W., Duncan, J.L., Brewer, C.C., Audo, I., Ayala, A.R., Branham, K., Cheetham, J.K., Daiger, S.P., Durham, T.A., Guan, B., Heon, E, Hoyng, C.B., Iannaccone, A., Kay, C.N., Michaelides, M., Pennesi, M.E., Singh, M.S., and Ullah, E.

Subjects
Extracellular Matrix Proteins, genetic structures, Mutation, otorhinolaryngologic diseases, Genetics, Humans, Usher Syndromes, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], eye diseases, Genetic Association Studies, Retinitis Pigmentosa, Article, Genetics (clinical)
Abstract

Contains fulltext : 251572.pdf (Publisher’s version ) (Closed access) We assessed genotype-phenotype correlations among the visual, auditory, and olfactory phenotypes of 127 participants with Usher syndrome (USH2) (n =80) or nonsyndromic autosomal recessive retinitis pigmentosa (ARRP) (n = 47) due to USH2A variants, using clinical data and molecular diagnostics from the Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) study. USH2A truncating alleles were associated with USH2 and had a dose-dependent effect on hearing loss severity with no effect on visual loss severity within the USH2 subgroup. A group of missense alleles in an interfibronectin domain appeared to be hypomorphic in ARRP. These alleles were associated with later age of onset, larger visual field area, better sensitivity thresholds, and better electroretinographic responses. No effect of genotype on the severity of olfactory deficits was observed. This study unveils a unique, tissue-specific USH2A allelic hierarchy with important prognostic implications for patient counseling and treatment trial endpoints. These findings may inform clinical care or research approaches in others with allelic disorders or pleiotropic phenotypes.

Published
2022

140. Acupuncture and Chinese herbal medicine for menopausal mood disorder: a randomized controlled trial.

Author

Wang, J., Liao, Y., You, Y., Liang, W., Wan, L., Yang, H., Liu, J., Li, Y., Wang, X., and Nie, G.

Subjects
HERBAL medicine, CHINESE medicine, RANDOMIZED controlled trials, AFFECTIVE disorders, ACUPUNCTURE
Abstract

Copyright of Climacteric is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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148. LBA8 Nivolumab (NIVO) + chemotherapy (chemo) vs chemo in patients (pts) with EGFR-mutated metastatic non-small cell lung cancer (mNSCLC) with disease progression after EGFR tyrosine kinase inhibitors (TKIs) in CheckMate 722

Author

Mok, T.S.K., primary, Nakagawa, K., additional, Park, K., additional, Ohe, Y., additional, Girard, N., additional, Kim, H.R., additional, Wu, Y-L., additional, Gainor, J., additional, Lee, S-H., additional, Chiu, C-H., additional, Sang-We, K., additional, Cheng-Ta, Y., additional, Liang, W., additional, Wu, L., additional, Lin, M-C., additional, Samol, J., additional, Zhang, X., additional, Sylvester, J., additional, Li, S., additional, and Yang, J.C-H., additional

Published
2022
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149. Temporary variation of shallow groundwater level derived from cultural noise interferometry in southern Longitudinal Valley, Taiwan

Author

Liang, W. and Lee, J.

Abstract

We have computed the cross-correlation functions (CCF) of the cultural noise to measure the temporal variation in seismic velocity for each station pair among the local Chihshang array in Taiwan, which was deployed in 2013-2020. A significant seasonal variation of asymmetric CCFs in the frequency band of 2-8 Hz, which is supposed to be the cultural noise, has been identified in this study. We further extract the velocity change (δv/v) by using the stretching method with the largest value up to 12% and found that the δv/v highly correlates with the nearby shallow groundwater level (GWL) fluctuation that usually occurs from September to November after rain season every year. On the other hand, the temporal variation of δv/v can only be observed for coda CCF with frequency higher than 3 Hz, which indicates that the source depth is within 30 m in the near surface layer based on its corresponding sensitivity kernel. The station pairs along the eastern side of Longitudinal Valley present smaller amplitude of δv/v, which may reflect a reduced GWL fluctuation in this region. Even though there is a clear 1-month lag between the rainfall and the GWL, there is no phase delay between the time series of the observed δv/v and the GWL. Our results suggest that we are capable of quantitatively monitoring the transient groundwater storage by a analyzing the cultural noise cross correlation functions in the Chihshang area, where is covered with a thick gravel bed in the southern Longitudinal Valley., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023
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150. Programmable metamaterials

Author

Rui Y. Wu, Liang W. Wu, Shi He, Shuo Liu, and Tie J. Cui

Abstract

As a major approach for controlling electromagnetic (EM) waves, metamaterials have experienced an abundant and rapid development in the 21st century. They have provided flexible and powerful techniques for controlling EM waves and brought many unique applications that are difficult to realise with natural materials. With increasing demands on dynamic controls of the EM waves, many innovations have been conducted in both three-dimensional metamaterials and two-dimensional metasurfaces, in which the meta-atom has been gradually evolved from passive to active. In 2014, coding and digital mechanisms were initially introduced to the metamaterials, further advancing the appearance of digitally programmable metamaterials. The programmable metamaterials have shown great potentials in not only real-time manipulations of the EM waves, but also direct information processing on the EM wave level. In this article, we present an in-depth review of the programmable EM metamaterials and metasurfaces, focusing on the programmable features including theoretical concepts, implementing methods and applications in EM controls. We first give a short retrospect of traditional metamaterials and metasurfaces, followed by the concepts and detailed discussions of digital coding and field-programmable metamaterials. Then, we introduce space-domain, time-domain and space–time-domain programmable metamaterials and metasurfaces, mainly focusing on their theories, functionalities, experimental implementations, and system-level applications. Finally, we conclude the current advances of the programmable metamaterials and metasurfaces, and give a prospect for the future developments.

Published
2023

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