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107. The Comprehensive Analysis of Efficacy and Safety of CalliSpheres® Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study

Author

Peng, Zhiyi, primary, Cao, Guohong, additional, Hou, Qinming, additional, Li, Ling, additional, Ying, Shihong, additional, Sun, Junhui, additional, Zhou, Guanhui, additional, Zhou, Jian, additional, Zhang, Xin, additional, Ji, Wenbin, additional, Yu, Zhihai, additional, Li, Tiefeng, additional, Zhu, Dedong, additional, Hu, Wenhao, additional, Ji, Jiansong, additional, Du, Haijun, additional, Shi, Changsheng, additional, Guo, Xiaohua, additional, Fang, Jian, additional, Han, Jun, additional, Gu, Wenjiang, additional, Xie, Xiaoxi, additional, Sun, Zhichao, additional, Xu, Huanhai, additional, Wu, Xia, additional, Hu, Tingyang, additional, Huang, Jing, additional, Hu, Hongjie, additional, Zheng, Jiaping, additional, Luo, Jun, additional, Chen, Yutang, additional, Yu, Wenqiang, additional, and Shao, Guoliang, additional

Published
2020
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109. Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres® in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres® Transarterial Chemoembolization in Liver Cancer (CTILC) Study

Author

Sun, Junhui, primary, Zhou, Guanhui, additional, Xie, Xiaoxi, additional, Gu, Wenjiang, additional, Huang, Jing, additional, Zhu, Dedong, additional, Hu, Wenhao, additional, Hou, Qinming, additional, Shi, Changsheng, additional, Li, Tiefeng, additional, Zhang, Xin, additional, Ji, Wenbin, additional, Ying, Shihong, additional, Peng, Zhiyi, additional, Zhou, Jian, additional, Yu, Zhihai, additional, Ji, Jiansong, additional, Du, Haijun, additional, Guo, Xiaohua, additional, Fang, Jian, additional, Han, Jun, additional, Xu, Huanhai, additional, Sun, Zhichao, additional, Yu, Wenqiang, additional, Shao, Guoliang, additional, Wu, Xia, additional, Hu, Hongjie, additional, Li, Ling, additional, Zheng, Jiaping, additional, Luo, Jun, additional, Chen, Yutang, additional, Cao, Guohong, additional, and Hu, Tingyang, additional

Published
2020
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113. Electro-mechanically controlled assembly of reconfigurable 3D mesostructures and electronic devices based on dielectric elastomer platforms

Author

Pang, Wenbo, primary, Cheng, Xu, additional, Zhao, Haojie, additional, Guo, Xiaogang, additional, Ji, Ziyao, additional, Li, Guorui, additional, Liang, Yiming, additional, Xue, Zhaoguo, additional, Song, Honglie, additional, Zhang, Fan, additional, Xu, Zheng, additional, Sang, Lei, additional, Huang, Wen, additional, Li, Tiefeng, additional, and Zhang, Yihui, additional

Published
2019
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114. Slope failure mechanism affected by mining subsidence: a case study of highway slopes in Yangquan, Shanxi Province, China

Author

Han Xudong, Zhang Chao, and Li Tiefeng

Subjects
Slope failure, Mining engineering, Subsidence, China, Geology, Mechanism (sociology)
Abstract

This paper presents details of highway slopes affected by a mining subsidence event that occurred in the Yangquan coal mining area of China in 2016. To ascertain the developmental characteristics of surface deformation, a few methods were applied for investigation and monitoring, such as multiple field investigations, unmanned aerial vehicle measurements, and time-series interferometric synthetic-aperture radar techniques. An accurate numerical simulation was conducted on two slopes for stability analysis and mining subsidence prediction. Results show that the mining subsidence developed from south to north, which was consistent with the mining direction; two subsidence centers were distributed on the ground, and the north one was located in the southeast slope foot of the highway. The influence of the mining subsidence whose subsidence magnitude reached 4 m is obviously different on both sides of the highway. Although the rock and soil structure were damaged seriously, the northwest slope was completely unstable, whereas the southeast slope remained standing. The differences were studied to illuminate that slope instability is not only due to the mechanical properties of rock mass decrease dramatically but also relates to the direction of horizontal traction force, the spatial distribution of the working face, and the effective free surface of the slope. This paper presents a case of mining landslide failure for researchers.

Published
2020

115. GIS-based Analysis of Distribution and Development Characteristics of Landslide Hazards in the Bailong River Basin

Author

LI Tiefeng and Mao Jiarui

Subjects
Hydrology, geography, geography.geographical_feature_category, business.industry, Drainage basin, Distribution (economics), Landslide, business, Geology
Abstract

The Bailong River Basin is one of the most landslide prone areas in China. Based on landslide interpretations from field investigations and high-precision remote sensing images, the influencing factors, distribution rules, and development characteristics of landslides in this region are examined using the powerful spatial analysis capability of the ArcGIS platform. This study identifies the following major influencing factors and provides corresponding conclusions. (1) Fault and tectonic activities: landslides in the study area are distributed mainly in the vicinity of the large and secondary fault zones (< 10 km) and in areas with high peak acceleration and seismic intensity (with a peak motion acceleration of 0.3 g and seismic intensity of a VIII-degree area). (2) Hydrological conditions: the closer to the river (an area of < 200 m), the higher the likelihood of a landslide to occur. Landslide density is highest in areas with substantial short-term rainfall (maximum rainfall amount within 30 min shows the highest correlation with landslides). (3) Topographic parameters of slopes: landslides are distributed mostly on sunny slopes (facing south, southwest, and southeast), gentle slopes (with an incline of approximately 15°–30°), and high mountain areas (with an elevation of approximately 1000–2000 m). (4) Vegetation: areas with low FC coverage (approximately 10%–45%) are prone to landslides, which are distributed mainly in grasslands and cultivated lands. (5) Human engineering activities: densely populated areas (urban areas) and both sides of roads (approximately 0–200 m from a road) are prone to landslides. Overall, landslides are sudden, periodic, synchronous, and occur in groups. The research results have certain reference value for hazard prevention and mitigation in the Bailong River Basin area.

Published
2020

117. Efficacy and safety of CalliSpheres® drug-eluting beads transarterial chemoembolization in patients with secondary liver cancer: a preliminary result from CTILC study

Author

Wu, Xia, primary, Ying, Shihong, additional, Huang, Jing, additional, Shi, Changsheng, additional, Ji, Jiansong, additional, Peng, Zhiyi, additional, Zhou, Guanhui, additional, Sun, Zhichao, additional, Sun, Junhui, additional, Yu, Wenqiang, additional, Hu, Wenhao, additional, Zhang, Xin, additional, Zhou, Jian, additional, Shao, Guoliang, additional, Yu, Zhihai, additional, Hou, Qinming, additional, Gu, Wenjiang, additional, Li, Tiefeng, additional, Xie, Xiaoxi, additional, Cao, Guohong, additional, Du, Haijun, additional, Zhu, Dedong, additional, Xu, Huanhai, additional, Han, Jun, additional, Ji, Wenbin, additional, Fang, Jian, additional, Li, Ling, additional, Zheng, Jiaping, additional, Luo, Jun, additional, Chen, Yutang, additional, Hu, Tingyang, additional, Hu, Hongjie, additional, and Guo, Xiaohua, additional

Published
2019
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119. Agile and Resilient Insect-Scale Robot

Author

Li, Tiefeng, primary, Zou, Zhanan, additional, Mao, Guoyong, additional, Yang, Xuxu, additional, Liang, Yiming, additional, Li, Chi, additional, Qu, Shaoxing, additional, Suo, Zhigang, additional, and Yang, Wei, additional

Published
2019
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122. Untethered soft robotic jellyfish

Author

Cheng, Tingyu, primary, Li, Guori, additional, Liang, Yiming, additional, Zhang, Mingqi, additional, Liu, Bangyuan, additional, Wong, Tuck-Whye, additional, Forman, Jack, additional, Chen, Mianhong, additional, Wang, Guanyun, additional, Tao, Ye, additional, and Li, Tiefeng, additional

Published
2018
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124. The New Design and Verification Based on the Coordinate Rotation Digital Computer

Author

Li Wenhua, Li Tiefeng, and Ma Caiwen

Subjects
Computer science, business.industry, Process (computing), Integrated circuit, Library and Information Sciences, Computer Graphics and Computer-Aided Design, Field (computer science), law.invention, Computational Theory and Mathematics, law, Lookup table, Convergence (routing), Trigonometric functions, Computer vision, Artificial intelligence, Trigonometry, CORDIC, business, Algorithm, Information Systems
Abstract

The Coordinate Rotation Digital Computer (CORDIC) is an effective convergence algorithm that is used to compute many trigonometric functions using shifts and additions. However, it is difficult to be completely implemented in Integrated Circuit (IC) field because the CORDIC has six complex operating modes. Currently the shortcoming of CORDIC in the IC field are the low precision and the long calculation time so that it can’t meet the actual needs. To over this, a new CORDIC algorithm that mainly adopts the iteration and the Looking-up Table (LUT) is introduced in this paper, which not only supports circular, linear and hyperbolic trigonometric function but it also has the interruption and overflowing functions. Most important is that it has higher precision and faster calculation speed than the conventional design. For example, the calculation speed of new CORDIC is up to 120 MHz. Using this frequency, it takes about 40 clock cycles to finish a trigonometric calculation. Moreover, the random verification model is firstly applied in the process of CORDIC design, which may automatically verify the definition domains of all input data and quickly analyze the precision errors of the calculated results. Finally, the precision errors between the expected results and the actual results are fully recorded by the verification model.

Published
2013

125. The Comprehensive Analysis of Efficacy and Safety of CalliSpheres® Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study.

Author

Peng, Zhiyi, Cao, Guohong, Hou, Qinming, Li, Ling, Ying, Shihong, Sun, Junhui, Zhou, Guanhui, Zhou, Jian, Zhang, Xin, Ji, Wenbin, Yu, Zhihai, Li, Tiefeng, Zhu, Dedong, Hu, Wenhao, Ji, Jiansong, Du, Haijun, Shi, Changsheng, Guo, Xiaohua, Fang, Jian, and Han, Jun

Subjects
LIVER cancer, CHEMOEMBOLIZATION, CANCER patients, CHINESE people, COHORT analysis
Abstract

This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of 384 days [95% confidence interval (CI): 375‐393 days]. CR and ORR were both higher in HCC patients compared with primary ICC patients and secondary liver cancer patients, while no difference was discovered in OS. Portal vein invasion was an independent risk factor for CR, while portal vein invasion, previous conventional TACE (cTACE) treatment, and abnormal blood creatinine (BCr) were independent risk factors for ORR. In addition, largest nodule size ≥5.0 cm, abnormal albumin (ALB), and abnormal total bilirubin (TBIL) independently correlated with unfavorable OS. Most liver function indexes were recovered to baseline levels at 1‐3 months after DEB-TACE. Common AEs were pain, fever, vomiting, and nausea; most of them were at mild grade. CalliSpheres® DEB-TACE is efficient and well tolerated in Chinese liver cancer patients. Portal vein invasion, previous cTACE treatment, largest nodule size, abnormal BCr, ALB, and TBIL correlate with worse prognosis independently. [ABSTRACT FROM AUTHOR]

Published
2020
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126. Electro-mechanically controlled assembly of reconfigurable 3D mesostructures and electronic devices based on dielectric elastomer platforms.

Author

Pang, Wenbo, Cheng, Xu, Zhao, Haojie, Guo, Xiaogang, Ji, Ziyao, Li, Guorui, Liang, Yiming, Xue, Zhaoguo, Song, Honglie, Zhang, Fan, Xu, Zheng, Sang, Lei, Huang, Wen, Li, Tiefeng, and Zhang, Yihui

Subjects
DIELECTRIC devices, ELECTRONIC equipment, ELASTOMERS, CAPACITORS
Abstract

The manufacture of 3D mesostructures is receiving rapidly increasing attention, because of the fundamental significance and practical applications across wide-ranging areas. The recently developed approach of buckling-guided assembly allows deterministic formation of complex 3D mesostructures in a broad set of functional materials, with feature sizes spanning nanoscale to centimeter-scale. Previous studies mostly exploited mechanically controlled assembly platforms using elastomer substrates, which limits the capabilities to achieve on-demand local assembly, and to reshape assembled mesostructures into distinct 3D configurations. This work introduces a set of design concepts and assembly strategies to utilize dielectric elastomer actuators as powerful platforms for the electro-mechanically controlled 3D assembly. Capabilities of sequential, local loading with desired strain distributions allow access to precisely tailored 3D mesostructures that can be reshaped into distinct geometries, as demonstrated by experimental and theoretical studies of ∼30 examples. A reconfigurable inductive–capacitive radio-frequency circuit consisting of morphable 3D capacitors serves as an application example. [ABSTRACT FROM AUTHOR]

Published
2020
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127. Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres® in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres® Transarterial Chemoembolization in Liver Cancer (CTILC) Study

Author

Sun, Junhui, Zhou, Guanhui, Xie, Xiaoxi, Gu, Wenjiang, Huang, Jing, Zhu, Dedong, Hu, Wenhao, Hou, Qinming, Shi, Changsheng, Li, Tiefeng, Zhang, Xin, Ji, Wenbin, Ying, Shihong, Peng, Zhiyi, Zhou, Jian, Yu, Zhihai, Ji, Jiansong, Du, Haijun, Guo, Xiaohua, and Fang, Jian

Subjects
CHEMOEMBOLIZATION, HEPATOCELLULAR carcinoma, PORTAL vein, ALANINE aminotransferase, ASPARTATE aminotransferase, LIVER cancer, PORTAL vein diseases
Abstract

The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this prospective study. Treatment response was assessed by modified Response Evaluation Criteria in Solid Tumors (mRECIST), and progression-free survival (PFS) as well as overall survival (OS) were determined. Liver function and adverse events (AEs) were assessed before and after DEB-TACE operation. Complete response (CR), partial response (PR), and objective response rate (ORR) were 22.9%, 60.7%, and 83.6%, respectively. The mean PFS was 362 (95% CI: 34.9‐375) days, the 6-month PFS rate was 89.4 ± 2.1%, while the mean OS was 380 (95% CI: 370‐389) days, and the 6-month OS rate was 94.4 ± 1.7%. Multivariate logistic regression revealed that portal vein invasion (p = 0.011) was an independent predictor of worse clinical response. Portal vein invasion (p = 0.040), previous cTACE treatment (p = 0.030), as well as abnormal serum creatinine level (BCr) (p = 0.017) were independent factors that predicted worse ORR. In terms of survival, higher Barcelona Clinic Liver Cancer (BCLC) stage (p = 0.029) predicted for worse PFS, and abnormal albumin (ALB) (p = 0.011) and total serum bilirubin (TBIL) (p = 0.009) predicted for worse OS. The number of patients with abnormal albumin, total protein (TP), TBIL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were augmented at 1 week posttreatment and were similar at 1‐3 months compared with baseline. The most common AEs were pain, fever, nausea, and vomiting, and no severe AEs were observed in this study. DEB-TACE was effective and tolerable in treating Chinese HCC patients, and portal vein invasion, previous cTACE treatment, abnormal BCr, ALB, and TBIL appear to be important factors that predict worse clinical outcome. [ABSTRACT FROM AUTHOR]

Published
2020
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130. Mapping the Mouse Cell Atlas by Microwell-Seq

Author

Han, Xiaoping, primary, Wang, Renying, additional, Zhou, Yincong, additional, Fei, Lijiang, additional, Sun, Huiyu, additional, Lai, Shujing, additional, Saadatpour, Assieh, additional, Zhou, Ziming, additional, Chen, Haide, additional, Ye, Fang, additional, Huang, Daosheng, additional, Xu, Yang, additional, Huang, Wentao, additional, Jiang, Mengmeng, additional, Jiang, Xinyi, additional, Mao, Jie, additional, Chen, Yao, additional, Lu, Chenyu, additional, Xie, Jin, additional, Fang, Qun, additional, Wang, Yibin, additional, Yue, Rui, additional, Li, Tiefeng, additional, Huang, He, additional, Orkin, Stuart H., additional, Yuan, Guo-Cheng, additional, Chen, Ming, additional, and Guo, Guoji, additional

Published
2018
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132. Soft Artificial Bladder Detrusor

Author

Yang, Xuxu, primary, An, Chengrui, additional, Liu, Shuting, additional, Cheng, Tingyu, additional, Bunpetch, Varitsara, additional, Liu, Yixiao, additional, Dong, Shurong, additional, Li, Shijian, additional, Zou, Xiaohui, additional, Li, Tiefeng, additional, Ouyang, Hongwei, additional, Wu, Zhaohui, additional, and Yang, Wei, additional

Published
2018
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133. Magmatic Gold Mineralization in the Western Qinling Orogenic Belt: Geology and Metallogenesis of the Baguamiao, Liba and Xiaogouli Gold Deposits

Author

Wang Xueming, Feng Jianzhong, Wang Dongbo, Zeng Yishan, and LI Tiefeng

Subjects
Tectonics, Water source, Geochemistry, Geology, Orogeny, Gold mineralization, Quartz, Texture (geology), Zircon
Abstract

The superlarge Baguamiao, large Liba and Xiaogouli gold deposits represent three typical gold deposits different from the Carlin type in the western Qinling Orogenic Belt. Based on Ar-Ar dating of quartz from ores, U-Pb dating of single zircon from granite, tracing of H and O isotopes and studies on the mineralogy and texture of spots and bleached alteration developed in wall rocks, this paper focuses the relations between gold deposits and granite to clarify the origin of gold deposits and the metallogenesis in the tectonic evolution of the Qinling Orogenic Belt. The comprehensive studies show that the age of the granite (148.1-244 Ma) is identical with that of the gold deposits (131.91-232.56 Ma). It is suggested that the granite has close temporal, spatial and genetic relationship with the gold deposits. The granite provides a heat source, water source and considerable amount of ore-forming material. Finally, it is concluded that the orogeny by collision, emplacement of the granite and positioning of the gold deposits represent a successive process. Both the granite and gold deposits resulted from the syn-orogeny and post-orogeny tectonic evolution.

Published
2010

137. Mapping Human Hematopoietic Hierarchy at Single Cell Resolution by Microwell-seq

Author

Lai, Shujing, primary, Xu, Yang, additional, Huang, Wentao, additional, Jiang, Mengmeng, additional, Chen, Haide, additional, Ye, Fang, additional, Wang, Renying, additional, Qiu, Yunfei, additional, Jiang, Xinyi, additional, Huang, Daosheng, additional, Mao, Jie, additional, Li, Yanwei, additional, Lu, Yingru, additional, Xie, Jin, additional, Fang, Qun, additional, Li, Tiefeng, additional, Huang, He, additional, Han, Xiaoping, additional, and Guo, Guoji, additional

Published
2017
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138. Fast-moving soft electronic fish

Author

Li, Tiefeng, primary, Li, Guorui, additional, Liang, Yiming, additional, Cheng, Tingyu, additional, Dai, Jing, additional, Yang, Xuxu, additional, Liu, Bangyuan, additional, Zeng, Zedong, additional, Huang, Zhilong, additional, Luo, Yingwu, additional, Xie, Tao, additional, and Yang, Wei, additional

Published
2017
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144. The Comprehensive Analysis of Efficacy and Safety of CalliSpheres®Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study

Author

Peng, Zhiyi, Cao, Guohong, Hou, Qinming, Li, Ling, Ying, Shihong, Sun, Junhui, Zhou, Guanhui, Zhou, Jian, Zhang, Xin, Ji, Wenbin, Yu, Zhihai, Li, Tiefeng, Zhu, Dedong, Hu, Wenhao, Ji, Jiansong, Du, Haijun, Shi, Changsheng, Guo, Xiaohua, Fang, Jian, Han, Jun, Gu, Wenjiang, Xie, Xiaoxi, Sun, Zhichao, Xu, Huanhai, Wu, Xia, Hu, Tingyang, Huang, Jing, Hu, Hongjie, Zheng, Jiaping, Luo, Jun, Chen, Yutang, Yu, Wenqiang, and Shao, Guoliang

Abstract

This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres®DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of 384 days [95% confidence interval (CI): 375‐393 days]. CR and ORR were both higher in HCC patients compared with primary ICC patients and secondary liver cancer patients, while no difference was discovered in OS. Portal vein invasion was an independent risk factor for CR, while portal vein invasion, previous conventional TACE (cTACE) treatment, and abnormal blood creatinine (BCr) were independent risk factors for ORR. In addition, largest nodule size ≥5.0 cm, abnormal albumin (ALB), and abnormal total bilirubin (TBIL) independently correlated with unfavorable OS. Most liver function indexes were recovered to baseline levels at 1‐3 months after DEB-TACE. Common AEs were pain, fever, vomiting, and nausea; most of them were at mild grade. CalliSpheres®DEB-TACE is efficient and well tolerated in Chinese liver cancer patients. Portal vein invasion, previous cTACE treatment, largest nodule size, abnormal BCr, ALB, and TBIL correlate with worse prognosis independently.

Published
2020
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145. Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres®in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres®Transarterial Chemoembolization in Liver Cancer (CTILC) Study

Author

Sun, Junhui, Zhou, Guanhui, Xie, Xiaoxi, Gu, Wenjiang, Huang, Jing, Zhu, Dedong, Hu, Wenhao, Hou, Qinming, Shi, Changsheng, Li, Tiefeng, Zhang, Xin, Ji, Wenbin, Ying, Shihong, Peng, Zhiyi, Zhou, Jian, Yu, Zhihai, Ji, Jiansong, Du, Haijun, Guo, Xiaohua, Fang, Jian, Han, Jun, Xu, Huanhai, Sun, Zhichao, Yu, Wenqiang, Shao, Guoliang, Wu, Xia, Hu, Hongjie, Li, Ling, Zheng, Jiaping, Luo, Jun, Chen, Yutang, Cao, Guohong, and Hu, Tingyang

Abstract

The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this prospective study. Treatment response was assessed by modified Response Evaluation Criteria in Solid Tumors (mRECIST), and progression-free survival (PFS) as well as overall survival (OS) were determined. Liver function and adverse events (AEs) were assessed before and after DEB-TACE operation. Complete response (CR), partial response (PR), and objective response rate (ORR) were 22.9%, 60.7%, and 83.6%, respectively. The mean PFS was 362 (95% CI: 34.9‐375) days, the 6-month PFS rate was 89.4 ± 2.1%, while the mean OS was 380 (95% CI: 370‐389) days, and the 6-month OS rate was 94.4 ± 1.7%. Multivariate logistic regression revealed that portal vein invasion (p = 0.011) was an independent predictor of worse clinical response. Portal vein invasion (p = 0.040), previous cTACE treatment (p = 0.030), as well as abnormal serum creatinine level (BCr) (p = 0.017) were independent factors that predicted worse ORR. In terms of survival, higher Barcelona Clinic Liver Cancer (BCLC) stage (p = 0.029) predicted for worse PFS, and abnormal albumin (ALB) (p = 0.011) and total serum bilirubin (TBIL) (p = 0.009) predicted for worse OS. The number of patients with abnormal albumin, total protein (TP), TBIL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were augmented at 1 week posttreatment and were similar at 1‐3 months compared with baseline. The most common AEs were pain, fever, nausea, and vomiting, and no severe AEs were observed in this study. DEB-TACE was effective and tolerable in treating Chinese HCC patients, and portal vein invasion, previous cTACE treatment, abnormal BCr, ALB, and TBIL appear to be important factors that predict worse clinical outcome.

Published
2020
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