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611 results on '"Li, Chunfu"'

101. Related and Unrelated Donor Transplantation for β Thalassemia Major: Results of an International Survey

Author

Li, Chunfu, primary, Mathews, Vikram, additional, George, Biju, additional, Kim, Soyoung, additional, Hebert, Kyle, additional, Jiang, Hua, additional, Li, Changgang, additional, Zhu, Yiping, additional, Keesler, Daniel A, additional, Agarwal, Rajni, additional, Boelens, Jaap Jan, additional, Dvorak, Christopher C., additional, Auletta, Jeffery, additional, Goyal, Rakesh Kumar, additional, Hanna, Rabi, additional, Kasow, Kimberly A., additional, Margolis, David, additional, Shenoy, Shalini, additional, Walters, Mark C., additional, and Eapen, Mary, additional

Published
2018
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107. Clonorchis sinensisinfection induces pathological changes in feline bile duct epithelium and alters biliary microbiota composition

Author

Li, Feng, Zhang, Yanli, Li, Chunfu, Li, Fenqi, Gan, Baojiang, Yu, Hong, Li, Jian, Feng, Xinyu, Hu, Wei, Li, Feng, Zhang, Yanli, Li, Chunfu, Li, Fenqi, Gan, Baojiang, Yu, Hong, Li, Jian, Feng, Xinyu, and Hu, Wei

Abstract

Background: Clonorchis sinensisis a zoonotic liver fluke that inhabits the bile ducts of the human liver for prolonged periods, leading to cholangiocarcinoma. Recent research indicates associations between altered biliary microbiota and bile duct disorders. However, the impacts of C. sinensisinfection on bile duct epithelium and subsequent effects on biliary microbiota remain unknown. Methods:Feline bile duct samples were collected from both uninfected and C. sinensis-infected cats. Histopathological examination was performed to assess epithelial changes, fibrosis, mucin and cell proliferation using hematoxylin-eosin staining and immunohistochemistry. Additionally, biliary microbiota composition was analyzed through 16S rRNA gene sequencing. Statistical analyses were conducted to compare the microbial diversity and relative abundance between infected and uninfected samples. Results:Histopathological analysis of infected feline bile ducts revealed prominent epithelial hyperplasia characterized by increased cell proliferation. Moreover, periductal fibrosis and collagen fibrosis were observed in infected samples compared to uninfected controls. Biliary microbial richness decreased with disease progression compared to uninfected controls. Streptococcusabundance positively correlated with disease severity, dominating communities in cancer samples. Predictive functional analysis suggested that C. sinensismay promote bile duct lesions by increasing microbial genes for carbohydrate metabolism, replication, and repair. Conclusions:This study provides comprehensive insights into the pathological effects of C. sinensisinfection on feline bile duct epithelium and its influence on biliary microbiota composition. These novel findings provide insight into C. sinensispathogenesis and could inform therapeutic development against human clonorchiasis. Further research is warranted to elucidate the underlying mechanisms driving these changes and their implications for host-parasite interactions.

Published
2024
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108. Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis

Author

Minghui Liu, Qi Shan, Wang Pu, Li Chunfu, and Wang Changhong

Subjects
0301 basic medicine, nonalcoholic fatty liver disease, Candidate gene, differentially expressed genes, Bioinformatics analysis, Down-Regulation, Receptors, Cell Surface, Bioinformatics, Collagen Type I, 03 medical and health sciences, Amyloid beta-Protein Precursor, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, Medicine, Humans, Disease process, beta Catenin, business.industry, Gene ontology, Gene Expression Profiling, Computational Biology, Nuclear Proteins, hub genes, General Medicine, Clinical Trial/Experimental Study, functional enrichment analysis, medicine.disease, Pathophysiology, Up-Regulation, Gene expression profiling, Collagen Type I, alpha 1 Chain, 030104 developmental biology, Gene Ontology, Etiology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, protein–protein interaction network, business, Carrier Proteins, Biomarkers, Research Article
Abstract

Supplemental Digital Content is available in the text, Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver condition worldwide. However, its etiology and fundamental pathophysiology for the disease process are poorly understood. In this study, we thus used bioinformatics to identify candidate genes potentially causative of severe NAFLD. Methods: Gene expression profile data GSE49541 were downloaded from the Gene Expression Omnibus database. Tissues samples from 32 severe and 40 mild NAFLD patients were evaluated to identify differentially expressed genes (DEGs) between the 2 groups, followed by analyses of Gene Ontology (GO) functions and Kyoto Encyclopedia of Genes and Genomes pathways. Then, a weighted protein–protein interaction (PPI) network was constructed, and subnetworks and candidate genes were screened. Moreover, the GSE48452 data (14 normal liver tissue samples and 18 nonalcoholic steatohepatitis samples) were used to verify the results obtained from the above analyses. Results: A total of 100 upregulated genes and 24 downregulated ones were identified in severe NAFLD. Functional enrichment and pathway analyses showed that these DEGs were mainly associated with cell adhesion, inflammatory response, and chemokine activity. The top 5 subnetworks were selected based on the PPI network. A total of 5 hub genes, including ubiquilin 4 (UBQLN4), amyloid-beta precursor protein (APP), sex hormone–binding globulin (SHBG), cadherin-associated protein beta 1 (CTNNB1) and collagen type I alpha 1 (COL1A1), were considered to be candidate genes for NAFLD. In addition, the verification data confirmed the status of COL1A1, SHBG, and APP as candidate genes. Conclusion: UBQLN4, APP, CTNNB1, SHBG, and COL1A1 might be involved in the development of NAFLD, and are proposed as the potential markers for predicting the development of this condition.

Published
2017

112. Transplant Outcomes in Beta-Thalassemia Major Patients Receiving Combined Granulocyte Colony-Stimulating Factor-Primed Bone Marrow and Cord Blood Graft Compared to Granulocyte Colony-Stimulating Factor-Primed Bone Marrow Alone

Author

Wen, Jianyun, primary, Haque, Qareen, additional, Pei, Fuyu, additional, Chen, Libai, additional, Ruan, Yongsheng, additional, Liu, Xuan , additional, He, Yuelin, additional, Feng, Xiaoqin, additional, Li, Chunfu, additional, and Wu, Xuedong, additional

Published
2018
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115. High Ferritin Before Transplant Increases Cytopenia Post-transplant in HLA Mismatched Hematopoietic Stem Cell Transplantation in β-Thalassemia Major

Author

Li Chunfu, Su Qingxia, Wu Xuedong, He Yuelin, Pei Fuyu, Peng Zhiyong, Liao Jianyun, Bai Jing, Liu Hua-ying, Wen Jianyun, Feng Xiaoqin, Zhou Xiaohui, Chen Libai, and Issa Moussa Mardo

Subjects
medicine.medical_specialty, Cytopenia, Univariate analysis, biology, business.industry, viruses, Thalassemia, medicine.medical_treatment, General Medicine, Human leukocyte antigen, Hematopoietic stem cell transplantation, medicine.disease, Gastroenterology, Virus, Ferritin, medicine.anatomical_structure, Internal medicine, White blood cell, medicine, biology.protein, business
Abstract

The objective is to find out the causes of Cytopenia post-engraftment (CPE) in hematopoietic stem cell transplantation (HSCT) for patients with β-thalassemia major (β-TM). For this, 61 consecutive β-TM patients underwent 7/8 HLA matched HSCT from January 1, 2009 to June 30, 2015 were retrospectively analyzed. Thirty-eight patients suffered from CPE and the remainder (n=23) associated without CPE. The effect of pre-transplant ferritin (PTF) and recipient and donor age on CPE were analyzed in the two groups. The CPE was defined as white blood cell counts less than 3.0×109/L for four weeks or longer without infection of cytomegalovirus, human parvovirus B19 virus and Epstein-Barr virus. As result, in univariate analysis, PTF level was a high-risk factor for CPE and significant higher in CPE group than no-CPE group (3927.9 ± 1314.9 vs 2291.0 ± 994.4 ng/ml, p=0.000). The result was also proved by multi-factor binary regression analysis (p=0.001). The optimal value of PTF level by R language (R 2.15.2) is 2500ng/ml, which is cutoff value in the two groups. The current study showed high PTF level was a high-risk factor of CPE for β-TM patients underwent 7/8 HLA-matched HSCT. PTF should be reduced below 2500ng/L if the 7/8 matched HSCT must be done.

Published
2018

119. Fludarabine- and low-dose cyclophosphamide-based conditioning regimens provided favorable survival and engraftment for unmanipulated hematopoietic cell transplantation from unrelated donors and matched siblings in patients with Fanconi anemia: results from the CBMTR

Author

Xu, Lanping, Lu, Yue, Chen, Jing, Sun, Shuwen, Hu, Shaoyan, Wang, Shunqing, Wu, Xuedong, Sun, Yuan, Wan, Dingming, Xu, Yajing, Jiang, Hui, Li, Chunfu, Lan, Mei, Jiang, Erlie, Li, Fei, Liu, Sixi, Tang, Yongmin, Lin, Fan, Lu, Peihua, Luo, Chengjuan, and Huang, Xiaojun

Published
2022
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133. A Novel Protocol Improves Engraftment in Tαβ +Cell Depleted Haplo-HSCT for Patients with Thalassemia Major

Author

Liao, Jianyun, Bu, Chaoke, He, Lan, He, Yuelin, He, Jujian, Chen, Dan, Lyu, Bo, Zhang, Weiwei, Tang, Haoran, Liu, Xinrui, and Li, Chunfu

Abstract

Background:Hematopoietic stem cell transplantation (HSCT) remains a proven curative approach for patients with thalassemia major (TM) over long-term practice. However, achieving successful engraftment and managing graft-versus-host disease (GVHD) continue to pose significant challenges. While low incidence of GVHD has been observed in Tαβ +cell-depleted HSCT (TDH) from haploidentical donors, graft failure (GF) remains a considerable concern, particularly in patients with TM. To enhance the engraftment in TM-TDH, we conducted this prospective/retrospective single-center clinical study.

Published
2023
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134. An UNB pattern

Author

Jin Yanhua, Wei Min, Cao Yong, Li Chunfu, Chen Jie, Chen Huawei, and Hu Lili

Subjects
Amplitude, Computer science, Electronic engineering, Codec, NASA Deep Space Network
Abstract

An UNB pattern of increasing sampling frequency is proposed. M-ary amplitude and M-ary VMSK (MVMSK) CoDec of UNB communication are presented to illustrate the UNB pattern. The UNB pattern can be used for deep space TT&C communication to improve its performance.

Published
2013

137. Successful engraftment determined by the quality rather than quantity of the haematopoietic graft: a lesson from co-transplantation of unrelated cord blood and mobilized haploidentical peripheral blood in monozygotic twins

Author

Liao, Jianyun, primary, Sylla, Goundo, additional, He, Yuelin, additional, Leung, Wing, additional, Liu, Xiaoting, additional, Chen, Jiaqi, additional, Peng, Zhiyong, additional, Pei, Fuyu, additional, Li, Na, additional, Ren, Yuqiong, additional, Feng, Xiaoqin, additional, Wu, Xuedong, additional, and Li, Chunfu, additional

Published
2016
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