101. Oral contraceptives alone and with spironolactone increase sCD40 ligand in PCOS patients
- Author
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Oktay Bilgir, Ayse Gul Kebapcilar, Yasar Yildiz, Arif Yuksel, Ahmet Alacacioglu, Cüneyt Eftal Taner, Ismail Sari, Didem Kozaci, and Levent Kebapcilar
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Spironolactone ,Ethinyl Estradiol ,chemistry.chemical_compound ,Young Adult ,Pharmacotherapy ,Internal medicine ,Ethinylestradiol ,medicine ,Humans ,Soluble cd40l ,CD40 Antigens ,Cyproterone Acetate ,Mineralocorticoid Receptor Antagonists ,business.industry ,Obstetrics and Gynecology ,Cyproterone acetate ,General Medicine ,Ligand (biochemistry) ,Polycystic ovary ,stomatognathic diseases ,Contraceptives, Oral, Combined ,Clinical research ,Endocrinology ,chemistry ,Drug Therapy, Combination ,Female ,business ,medicine.drug ,Polycystic Ovary Syndrome - Abstract
The present study was designed to determine the effect of oral contraceptives (OCP) and OCP plus spironolactone (Sp) on plasma soluble CD40L levels in polycystic ovary syndrome (PCOS) patients.Fifty-six women with PCOS were randomized into two treatment protocols: ethinylestradiol + cyproterone acetate (2 mg, EE/CA; n = 28), and EE/CA with spironolactone (Sp; n = 28). Plasma sCD40L levels were measured before and after a 3-month treatment.Before the initiation of treatment, the sCD40L levels were not significantly different between the groups [EE/CA (1.33 ng/mL) vs. EE/CA + Sp (1.23 ng/mL); P0.05]. In the post-treatment period, sCD40L concentrations were increased compared with pre-treatment values in the EE/CA and EE/CA + Sp groups (1.33 vs. 2.70 ng/mL, P = 0.011; and 1.23 vs. 2.41 ng/mL, P = 0.017; respectively).Increased plasma concentrations of sCD40L are associated with OCP and OCP + Sp treatment regimens in PCOS patients.
- Published
- 2009