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101. Whole Genome Sequencing of SARS-CoV-2 Strains in COVID-19 Patients From Djibouti Shows Novel Mutations and Clades Replacing Over Time

Author

Osman, Ikram Omar, Levasseur, Anthony, Brechard, Ludivine, Abdillahi Hassan, Iman, Salah Abdillahi, Idil, Ali Waberi, Zeinab, Delerce, Jeremy, Bedotto, Marielle, Houhamdi, Linda, Fournier, Pierre-Edouard, Colson, Philippe, Aboubaker, Mohamed Houmed, Raoult, Didier, Devaux, Christian, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, SARS-CoV-2, South African variant, COVID-19, UK variant, General Medicine, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, epidemics, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Medicine, Marseille 4 variant, Djibouti, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Original Research
Abstract

International audience; Since the start of COVID-19 pandemic the Republic of Djibouti, in the horn of Africa, has experienced two epidemic waves of the virus between April and August 2020 and between February and May 2021. By May 2021, COVID-19 had affected 1.18% of the Djiboutian population and caused 152 deaths. Djibouti hosts several foreign military bases which makes it a potential hot-spot for the introduction of different SARS-CoV-2 strains. We genotyped fifty three viruses that have spread during the two epidemic waves. Next, using spike sequencing of twenty-eight strains and whole genome sequencing of thirteen strains, we found that Nexstrain clades 20A and 20B with a typically European D614G substitution in the spike and a frequent P2633L substitution in nsp16 were the dominant viruses during the first epidemic wave, while the clade 20H South African variants spread during the second wave characterized by an increase in the number of severe forms of COVID-19.

Published
2021
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104. Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: is it still a virus?

Author

Aherfi, Sarah, primary, Brahim Belhaouari, Djamal, additional, Pinault, Lucile, additional, Baudoin, Jean-Pierre, additional, Decloquement, Philippe, additional, Abrahao, Jonatas, additional, Colson, Philippe, additional, Levasseur, Anthony, additional, Lamb, David C., additional, Chabriere, Eric, additional, Raoult, Didier, additional, and La Scola, Bernard, additional

Published
2021
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106. Analysis of SARS-CoV-2 variants from 24,181 patients exemplifies the role of globalisation and zoonosis in pandemics

Author

Colson, Philippe, primary, Fournier, Pierre-Edouard, additional, Chaudet, Hervé, additional, Delerce, Jérémy, additional, Giraud-Gatineau, Audrey, additional, Houhamdi, Linda, additional, Andrieu, Claudia, additional, Brechard, Ludivine, additional, Bedotto, Marielle, additional, Prudent, Elsa, additional, Gazin, Céline, additional, Beye, Mamadou, additional, Burel, Emilie, additional, Dudouet, Pierre, additional, Tissot-Dupont, Hervé, additional, Gautret, Philippe, additional, Lagier, Jean-Christophe, additional, Million, Matthieu, additional, Brouqui, Philippe, additional, Parola, Philippe, additional, Drancourt, Michel, additional, Scola, Bernard La, additional, Levasseur, Anthony, additional, and Raoult, Didier, additional

Published
2021
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107. Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage

Author

Colson, Philippe, primary, Levasseur, Anthony, additional, Delerce, Jeremy, additional, Pinault, Lucile, additional, Dudouet, Pierre, additional, Devaux, Christian, additional, Fournier, Pierre-Edouard, additional, La Scola, Bernard, additional, Lagier, Jean-Christophe, additional, and Raoult, Didier, additional

Published
2021
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108. Gut Microbiota in Military International Travelers with Doxycycline Malaria Prophylaxis: Towards the Risk of a Simpson Paradox in the Human Microbiome Field

Author

Javelle, Emilie, primary, Mayet, Aurélie, additional, Million, Matthieu, additional, Levasseur, Anthony, additional, Allodji, Rodrigue S., additional, Marimoutou, Catherine, additional, Lavagna, Chrystel, additional, Desplans, Jérôme, additional, Fournier, Pierre Edouard, additional, Raoult, Didier, additional, and Texier, Gaëtan, additional

Published
2021
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109. Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal

Author

Baron, Sophie Alexandra, primary, Mediannikov, Oleg, additional, Abdallah, Rim, additional, Kuete Yimagou, Edmond, additional, Medkour, Hacène, additional, Dubourg, Gregory, additional, Elamire, Youssouf, additional, Afouda, Pamela, additional, Ngom, Issa Isaac, additional, Angelakis, Emmanouil, additional, Davoust, Bernard, additional, Diatta, Georges, additional, Barciela, Amanda, additional, Hernandez-Aguilar, R. Adriana, additional, Sokhna, Cheikh, additional, Caputo, Aurelia, additional, Levasseur, Anthony, additional, Rolain, Jean-Marc, additional, and Raoult, Didier, additional

Published
2021
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111. Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa: An investigational study

Author

Colson, Philippe, Levasseur, Anthony, Gautret, Philippe, Fenollar, Florence, Thuan Hoang, Van, Delerce, Jeremy, Bitam, Idir, Saile, Rachid, Maaloum, Mossaab, Padane, Abdou, Bedotto, Marielle, Brechard, Ludivine, Bossi, Vincent, Ben Khedher, Mariem, Chaudet, Hervé, Million, Matthieu, Tissot-Dupont, Hervé, Lagier, Jean-Christophe, Mboup, Souleymane, Fournier, Pierre-Edouard, Raoult, Didier, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Ecole Nationale Supérieure en Sciences de L'Aliment et des Industries Agroalimentaire (ENSAIA), Faculty of Sciences Ben M’sik, Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation [Dakar, Sénégal] (IRESSEF), Centre d'épidémiologie et de santé publique des armées [Marseille] (CESPA), Service de Santé des Armées, Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA)

Subjects
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Infectious Diseases, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Public Health, Environmental and Occupational Health, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

112. SARS-CoV-2 European resurgence foretold: interplay of introductions and persistence by leveraging genomic and mobility data

Author

Lemey, Philippe, Ruktanonchai, Nick W., Hong, Samuel, Colizza, Vittoria, Poletto, Chiara, Van den Broeck, Frederik, Gill, Mandev, Ji, Xiang, Levasseur, Anthony, Sadilek, Adam, Lai, Shengjie, Tatem, Andrew, Baele, Guy, Suchard, Marc, and Dellicour, Simon

Subjects
Epidemiology, SARS-CoV-2, international mobility, Virology, COVID-19, Statistical Epidemiology, phylogeography, second wave
Abstract

Following the first wave of SARS-CoV-2 infections in spring 2020, Europe experienced a resurgence of the virus starting late summer that was deadlier and more difficult to contain. Relaxed intervention measures and summer travel have been implicated as drivers of the second wave. Here, we build a phylogeographic model to evaluate how newly introduced lineages, as opposed to the rekindling of persistent lineages, contributed to the COVID-19 resurgence in Europe. We inform this model using genomic, mobility and epidemiological data from 10 West European countries and estimate that in many countries more than 50% of the lineages circulating in late summer resulted from new introductions since June 15th. The success in onwards transmission of these lineages is predicted by SARS-CoV-2 incidence during this period. Relatively early introductions from Spain into the United Kingdom contributed to the successful spread of the 20A.EU1/B.1.177 variant. The pervasive spread of variants that have not been associated with an advantage in transmissibility highlights the threat of novel variants of concern that emerged more recently and have been disseminated by holiday travel. Our findings indicate that more effective and coordinated measures are required to contain spread through cross-border travel. The research leading to these results has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 725422-ReservoirDOCS) and from the European Union's Horizon 2020 project MOOD (grant agreement no. 874850), and the Bill & Melinda Gates Foundation (OPP1094793 and INV-024911). The Artie Network receives funding from the Wellcome Trust through project 206298/Z/17/Z. PL acknowledges support by the Research Foundation - Flanders ('Fonds voor Wetenschappelijk Onderzoek - Vlaanderen', G066215N, G0D5117N and G0B9317N). GB acknowledges support from the 'lnterne Fondsen KU Leuven'/Internal Funds KU Leuven under grant agreement C14/18/094, and the Research Foundation - Flanders ('Fonds voor Wetenschappelijk Onderzoek - Vlaanderen', G0E1420N). MAS acknowledges support from National Institutes of Health grant U19 Al135995 and R01 Al153044. SD is supported by the Fonds National de la Recherche Scienti(lque (FNRS, Belgium). We also gratefully acknowledge support from NVIDIA Corporation with the donation of parallel computing resources used for this research. Submitted version Preprint version

Published
2021

113. Draft Genome Sequence of Comamonas aquatilis Strain LK (= CSUR P6418 = CECT 9772), Isolated from the Planarian Schmidtea mediterranea

Author

Kangale, Luis Johnson, Levasseur, Anthony, Raoult, Didier, Ghigo, Eric, Fournier, Pierre-Edouard, Microbes évolution phylogénie et infections (MEPHI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genome Sequences, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract

Comamonas aquatilis was defined as a new Comamonas species based on its 16S rRNA sequence, but the genome from the type strain SB30-Cr27-3T (= CIP 111491T = CCM 8815T) is not available. We have cultivated from the planarian Schmidtea mediterranea a Comamonas aquatilis strain, LK (= CSUR P6418 = CECT 9772), that exhibits 100% 16S rRNA sequence similarity to strain SB30-Cr27-3T., Comamonas aquatilis was defined as a new Comamonas species based on its 16S rRNA sequence, but the genome from the type strain SB30-Cr27-3T (= CIP 111491T = CCM 8815T) is not available. We have cultivated from the planarian Schmidtea mediterranea a Comamonas aquatilis strain, LK (= CSUR P6418 = CECT 9772), that exhibits 100% 16S rRNA sequence similarity to strain SB30-Cr27-3T. We have sequenced the genome of strain LK and obtained a chromosome of 4,899,818 bp, with a G+C content of 61.75%, assembled into two contigs.

Published
2021

114. Draft Genome Sequence of Vogesella oryzae L3B39 T , Isolated from the Rhizosphere of Saline-Tolerant Pokkali Rice

Author

Kangale, Luis Johnson, Levasseur, Anthony, Anani, Hussein, Raoult, Didier, Ghigo, Eric, Fournier, Pierre-Edouard, Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Microbes évolution phylogénie et infections (MEPHI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, mental disorders, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, food and beverages, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract

International audience; ABSTRACT Here, we report the draft genome sequence of Vogesella oryzae L3B39 T (CSUR Q2602 T = DSM 28780), which is a Vogesella species isolated from the rhizosphere of saline-tolerant pokkali rice. The genome sequence was assembled into 58 contigs for a total size of 3,415,129 bp, with a G+C content of 62.3%.

Published
2021

115. Bacterial infections in humans and nonhuman primates from Africa : expanding the knowledge

Author

Medkour, Hacene, Amona, Inestin, Akiana, Jean, Laidoudi, Younes, Davoust, Bernard, Bitam, Idir, Lafri, Ismail, Levasseur, Anthony, Diatta, Georges, Sokhna, Cheikh, Hernandez-Aguilar, R. Adriana, Barciela, Amanda, Gorsane, Slim, Banga-Mboko, Henri, Didier Raoult, Fenollar, Florence, Mediannikov, Oleg, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire national de santé publique, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Maladies infectieuses persistantes et émergentes en Afrique de l’Ouest [Dakar, Sénégal] (Equipe 3 - VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Jane Goodall Inst Spain & Senegal, Service de Santé des Armées, Université Marien Ngouabi, Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA)

Subjects
Primates, Staphylococcus aureus, SENEGAL, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, CONGO, DJIBOUTI, Hominidae, Original Contribution, Bacterial Infections, infectious diseases, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Africa, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, surveillance, Animals, emergence, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, humans, bacteria, ALGERIE, Phylogeny, Nonhuman primates, 050, 080, 052, 084
Abstract

International audience; The close phylogenetic relationship between humans and other primates creates exceptionally high potential for pathogen exchange. The surveillance of pathogens in primates plays an important role in anticipating possible outbreaks. In this study, we conducted a molecular investigation of pathogenic bacteria in feces from African nonhuman primates (NHPs). We also investigated the pathogens shared by the human population and gorillas living in the same territory in the Republic of Congo. In total, 93% of NHPs (n=176) and 95% (n=38) of humans were found to carry at least one bacterium. Non-pallidum Treponema spp. (including T. succinifaciens, T. berlinense, and several potential new species) were recovered from stools of 70% of great apes, 88% of monkeys, and 79% of humans. Non-tuberculosis Mycobacterium spp. were also common in almost all NHP species as well as in humans. In addition, Acinetobacter spp., members of the primate gut microbiota, were mainly prevalent in human and gorilla. Pathogenic Leptospira spp. were highly present in humans (82%) and gorillas (66%) stool samples in Congo, but were absent in the other NHPs, therefore suggesting a possible gorillas-humans exchange. Particular attention will be necessary for enteropathogenic bacteria detected in humans such as Helicobacter pylori, Salmonella spp. (including S. typhi/paratyphi), Staphyloccocus aureus, and Tropheryma whipplei, some of which were also present in gorillas in the same territory (S. aureus and T. whipplei). This study enhances our knowledge of pathogenic bacteria that threaten African NHPs and humans by using a non-invasive sampling technique. Contact between humans and NHPs results in an exchange of pathogens. Ongoing surveillance, prevention, and treatment strategies alone will limit the spread of these infectious agents.

Published
2021

117. First evidence of human‐to‐dog transmission of SARS‐CoV‐2 B.1.160 variant in France.

Author

Medkour, Hacène, Catheland, Sébastien, Boucraut‐Baralon, Corine, Laidoudi, Younes, Sereme, Youssouf, Pingret, Jean‐Luc, Million, Matthieu, Houhamdi, Linda, Levasseur, Anthony, Cabassu, Julien, and Davoust, Bernard

Subjects
COVID-19, SARS-CoV-2, PETS, DOGS
Abstract

Since the start of the coronavirus disease of 2019 (COVID‐19) pandemic, several episodes of human‐to‐animal severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission have been described in different countries. The role of pets, especially domestic dogs, in the COVID‐19 epidemiology is highly questionable and needs further investigation. In this study, we report a case of COVID‐19 in a French dog living in close contact with its owners who were COVID‐19 patients. The dog presented rhinitis and was sampled 1 week after its owners (a man and a woman) were tested positive for COVID‐19. The nasal swabs for the dog tested remained positive for SARS‐CoV‐2 by reverse transcription quantitative real‐time PCR (RT‐qPCR) 1 month following the first diagnosis. Specific anti‐SARS‐CoV‐2 antibodies were detectable 12 days after the first diagnosis and persisted for at least 5 months as tested using enzyme‐linked immunoassay (ELISA) and automated western blotting. The whole‐genome sequences from the dog and its owners were 99%–100% identical (with the man and the woman's sequences, respectively) and matched the B.1.160 variant of concern (Marseille‐4 variant), the most widespread in France at the time the dog was infected. This study documents the first detection of B.1.160 in pets (a dog) in France, and the first canine genome recovery of the B.1.160 variant of global concern. Moreover, given the enhanced infectivity and transmissibility of the Marseille‐4 variant for humans, this case also highlights the risk that pets may potentially play a significant role in SARS‐CoV‐2 outbreaks and may transmit the infection to humans. We have evidence of human‐to‐dog transmission of the Marseille‐4 variant since the owners were first to be infected. Finally, owners and veterinarians must be vigilent for canine COVID‐19 when dogs are presented with respiratory clinical signs. [ABSTRACT FROM AUTHOR]

Published
2022
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119. A Listeria monocytogenes clone in human breast milk associated with severe acute malnutrition in West Africa: A multicentric case-controlled study

Author

Sarr, Marièma, primary, Tidjani Alou, Maryam, additional, Delerce, Jeremy, additional, Khelaifia, Saber, additional, Diagne, Nafissatou, additional, Diallo, Aldiouma, additional, Bassene, Hubert, additional, Bréchard, Ludivine, additional, Bossi, Vincent, additional, Mbaye, Babacar, additional, Lagier, Jean-Christophe, additional, Levasseur, Anthony, additional, Sokhna, Cheikh, additional, Million, Matthieu, additional, and Raoult, Didier, additional

Published
2021
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121. Marseilleviruses: An Update in 2021

Author

Sahmi-Bounsiar, Dehia, primary, Rolland, Clara, additional, Aherfi, Sarah, additional, Boudjemaa, Hadjer, additional, Levasseur, Anthony, additional, La Scola, Bernard, additional, and Colson, Philippe, additional

Published
2021
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122. Gut Microbiota Influences Plasmodium Falciparum Malaria Susceptibility

Author

Kodio, Aly, primary, Coulibaly, Drissa, additional, Doumbo, Safiatou, additional, Konaté, Salimata, additional, Koné, Abdoulaye Kassoum, additional, Tall, Lamine, additional, Konaté, Ahmed, additional, Guindo, Boureima, additional, L’ollivier, Coralie, additional, Levasseur, Anthony, additional, Bittar, Fadi, additional, Doumbo, Ogobara K., additional, Didier, Raoult, additional, Thera, Mahamadou A., additional, and Ranque, Stéphane, additional

Published
2021
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123. Mink, SARS-CoV-2, and the Human-Animal Interface

Author

Fenollar, Florence, primary, Mediannikov, Oleg, additional, Maurin, Max, additional, Devaux, Christian, additional, Colson, Philippe, additional, Levasseur, Anthony, additional, Fournier, Pierre-Edouard, additional, and Raoult, Didier, additional

Published
2021
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124. Investigation of a COVID-19 outbreak on the Charles de Gaulle aircraft carrier, March to April 2020: a retrospective cohort study.

Author

de Laval, Franck, Chaudet, Hervé, Gorgé, Olivier, Marchi, Joffrey, Lacrosse, Constance, Dia, Aissata, Marbac, Vanessa, Mrenda, Bakridine Mmadi, Texier, Gaëtan, Letois, Flavie, Chapus, Charles, Sarilar, Véronique, Tournier, Jean-Nicolas, Levasseur, Anthony, Cobola, Jacques, Nolent, Flora, Dutasta, Fabien, Janvier, Frédéric, Meynard, Jean-Baptiste, and de Santi, Vincent Pommier

Published
2022
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127. SARS-CoV-2 European resurgence foretold: interplay of introductions and persistence by leveraging genomic and mobility data

Author

Lemey, Philippe, primary, Ruktanonchai, Nick, additional, Hong, Samuel, additional, Colizza, Vittoria, additional, Poletto, Chiara, additional, Broeck, Frederik Van den, additional, Gill, Mandev, additional, Ji, Xiang, additional, Levasseur, Anthony, additional, Sadilek, Adam, additional, Lai, Shengjie, additional, Tatem, Andrew, additional, Baele, Guy, additional, Suchard, Marc, additional, and Dellicour, Simon, additional

Published
2021
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128. Implementation of an in-house real-time reverse transcription-PCR assay for the rapid detection of the SARS-CoV-2 Marseille-4 variant

Author

Bedotto, Marielle, primary, Fournier, Pierre-Edouard, additional, Houhamdi, Linda, additional, Levasseur, Anthony, additional, Delerce, Jeremy, additional, Pinault, Lucile, additional, Padane, Abdou, additional, Chamieh, Amanda, additional, Tissot-Dupont, Hervé, additional, Brouqui, Philippe, additional, Sokhna, Cheikh, additional, Azar, Eid, additional, Saile, Rachid, additional, Mboup, Souleymane, additional, Bitam, Idir, additional, Colson, Philippe, additional, and Raoult, Didier, additional

Published
2021
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129. Investigation of a COVID-19 Outbreak on an Aircraft Carrier: An Epidemic Model Based on Real Data

Author

de Laval, Franck, primary, Chaudet, Hervé, additional, Gorgé, Olivier, additional, Marchi, Joffrey, additional, Lacrosse, Constance, additional, Dia, Aissata, additional, Marbac, Vanessa, additional, Mmadi Mrenda, Bakridine, additional, Texier, Gaëtan, additional, Letois, Flavie, additional, Chapus, Charles, additional, Sarilar, Véronique, additional, Tournier, Jean-Nicolas, additional, Levasseur, Anthony, additional, Cobola, Jacques, additional, Nolent, Flora, additional, Dutasta, Fabien, additional, Janvier, Frédéric, additional, Meynard, Jean-Baptiste, additional, and de Santi, Vincent Pommier, additional

Published
2021
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131. [A health service]

Author

Mediannikov, Oleg, Fenollar, Florence, Davoust, Bernard, Amanzougaghene, Nadia, Lepidi, Hubert, Arzouni, Jean-Pierre, Diatta, Georges, Sokhna, Cheikh, Delerce, Jeremy, Levasseur, Anthony, Raoult, Didier, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
MESH: Community Health Services, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Health Priorities, MESH: Hospitals, General, MESH: State Medicine, Models, Theoretical, Hospitals, General, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, State Medicine, MESH: Health Priorities, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Preventive Health Services, MESH: Preventive Health Services, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Community Health Services, MESH: Models, Theoretical, Mexico, MESH: Mexico, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

134. Construction of engineered bifunctional enzymes and their overproduction in Aspergillus niger for improved enzymatic tools to degrade agricultural by-products

Author

Levasseur, Anthony, Navarro, David, Punt, Peter J., Belaich, Jean-Pierre, Asther, Marcel, and Record, Eric

Subjects
Aspergillus -- Genetic aspects, Enzymes -- Structure, Esterases -- Structure, Biological sciences
Abstract

Two chimeric enzymes, FLX and FLXLC, are constructed and successfully overproduced in Aspergillus niger. The results have shown that the fusion of naturally free cell wall hydrolases and an A. niger-derived carbohydrate-binding module (CBM) onto bifunctional enzymes enables the increase of the synergistic effect on the degradation of complex substrates.

Published
2005

135. Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa

Author

Colson, Philippe, primary, Levasseur, Anthony, additional, Gautret, Philippe, additional, Fenollar, Florence, additional, Hoang, Van Thuan, additional, Delerce, Jeremy, additional, Bitam, Idir, additional, Saile, Rachid, additional, Maaloum, Mossaab, additional, Padane, Abdou, additional, Bedotto, Marielle, additional, Brechard, Ludivine, additional, Bossi, Vincent, additional, Khedher, Mariem Ben, additional, Chaudet, Hervé, additional, Million, Matthieu, additional, Tissot-Dupont, Hervé, additional, Lagier, Jean-Christophe, additional, Mboup, Souleymane, additional, Fournier, Pierre-Edouard, additional, and Raoult, Didier, additional

Published
2020
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138. Enteroviruses from Humans and Great Apes in the Republic of Congo: Recombination within Enterovirus C Serotypes

Author

Amona, Inestin, primary, Medkour, Hacène, additional, Akiana, Jean, additional, Davoust, Bernard, additional, Tall, Mamadou Lamine, additional, Grimaldier, Clio, additional, Gazin, Celine, additional, Zandotti, Christine, additional, Levasseur, Anthony, additional, Scola, Bernard La, additional, Raoult, Didier, additional, Fenollar, Florence, additional, Banga-Mboko, Henri, additional, and Mediannikov, Oleg, additional

Published
2020
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139. Flying Fox Hemolytic Fever, Description of a New Zoonosis Caused by Candidatus Mycoplasma haemohominis

Author

Descloux, Elodie, primary, Mediannikov, Oleg, additional, Gourinat, Ann-Claire, additional, Colot, Julien, additional, Chauvet, Martine, additional, Mermoud, Isabelle, additional, Desoutter, Denise, additional, Cazorla, Cécile, additional, Klement-Frutos, Elise, additional, Antonini, Luca, additional, Levasseur, Anthony, additional, Bossi, Vincent, additional, Davoust, Bernard, additional, Merlet, Audrey, additional, Goujart, Marie-Amélie, additional, Oedin, Malik, additional, Brescia, Fabrice, additional, Laumond, Sylvie, additional, Fournier, Pierre-Edouard, additional, and Raoult, Didier, additional

Published
2020
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141. An Earliest Endosymbiont, Wolbachia massiliensis sp. nov., Strain PL13 from the Bed Bug (Cimex hemipterus), Type Strain of a New Supergroup T

Author

Laidoudi, Younes, primary, Levasseur, Anthony, additional, Medkour, Hacène, additional, Maaloum, Mossaab, additional, Ben Khedher, Mariem, additional, Sambou, Masse, additional, Bassene, Hubert, additional, Davoust, Bernard, additional, Fenollar, Florence, additional, Raoult, Didier, additional, and Mediannikov, Oleg, additional

Published
2020
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143. Culturing Ancient Bacteria Carrying Resistance Genes from Permafrost and Comparative Genomics with Modern Isolates

Author

Afouda, Pamela, primary, Dubourg, Grégory, additional, Levasseur, Anthony, additional, Fournier, Pierre-Edouard, additional, Delerce, Jeremy, additional, Mediannikov, Oleg, additional, Diene, Seydina M., additional, Nahon, Daniel, additional, Bourlès, Didier, additional, Rolain, Jean-Marc, additional, and Raoult, Didier, additional

Published
2020
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144. Fungal Strategies for Lignin Degradation

Author

Sigoillot, Jean-Claude, primary, Berrin, Jean-Guy, additional, Bey, Mathieu, additional, Lesage-Meessen, Laurence, additional, Levasseur, Anthony, additional, Lomascolo, Anne, additional, Record, Eric, additional, and Uzan-Boukhris, Eva, additional

Published
2012
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145. Tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: Is it still a virus?

Author

Aherfi, Sarah, primary, Brahim Belhaouari, Djamal, additional, Pinault, Lucile, additional, Baudoin, Jean-Pierre, additional, Decloquement, Philippe, additional, Abrahao, Jonatas, additional, Colson, Philippe, additional, Levasseur, Anthony, additional, Lamb, David C., additional, Chabriere, Eric, additional, Raoult, Didier, additional, and La Scola, Bernard, additional

Published
2020
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146. Characterisation of the Vaginal Microbiota Using Culturomics and Metagenomics Suggests Transplantation of Gut Microbiota Into the Vagina During Bacterial Vaginosis

Author

Diop, Khoudia, primary, Fall, Ndeye Safietou, additional, Levasseur, Anthony, additional, Diagne, Nafissatou, additional, Bachar, Dipankar, additional, Bretelle, Florence, additional, Sokhna, Cheikh, additional, Lagier, Jean-Christophe, additional, Raoult, Didier, additional, and Fenollar, Florence, additional

Published
2020
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148. Isolation and Molecular Characterization of Enteroviruses from Great Apes and Humans in the Republic of Congo: Recombination within Enterovirus C Serotypes

Author

Amona, Inestin, primary, Medkour, Hacène, additional, Akiana, Jean, additional, Davoust, Bernard, additional, Tall, Mamadou Lamine, additional, Grimaldier, Clio, additional, Gazin, Celine, additional, Zandotti, Christine, additional, Levasseur, Anthony, additional, Scola, Bernard La, additional, Raoult, Didier, additional, Fenollar, Florence, additional, Banga-Mboko, Henri, additional, and Mediannikov, Oleg, additional

Published
2020
Full Text
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