Sikolia Wanyonyi, Bellington Vwalika, Peter Waiswa, Muchabayiwa Francis Gidiri, Kateri B. Donahoe, Elsa Jacinto, Andrea B. Pembe, George K. Chilinda, Agnes Binagwaho, Lenka Benova, Stephen Peter Munjanja, and Claudia Hanson
Background High-risk pregnancies, such as twin pregnancies, deserve particular attention as mortality is very high in this group. With a view to inform policy and national guidelines development for the Sustainable Development Goals, we reviewed national training materials, guidelines, and policies underpinning the provision of care in relation to twin pregnancies and assessed care provided to twins in 8 Eastern and Southern African countries: Kenya, Malawi, Mozambique, Rwanda, Tanzania, Uganda, Zambia, and Zimbabwe. Methods and findings We located policies and guidelines by reviewing national repositories and by contacting experts to systematically map country-level maternal and newborn training materials, guidelines, and policies. We extracted recommendations for care for twins spanning ante-, intra-, and postpartum care that typically should be offered during twin pregnancies and childbirth. We compared care provided for mothers of twins to that provided for mothers of singletons during the ante-, intra-, and postpartum period and computed neonatal mortality rates using the most recent Demographic and Health Surveys (DHS) data for each country. There was a paucity of guidance on care specifically for twin or multiple pregnancies: None of the countries provided clear guidance on additional number of antenatal care visits or specific antenatal content, while 7 of the 8 countries recommended twins to be delivered in a comprehensive emergency obstetric and neonatal care facility. These results were mirrored by DHS results of 73,462 live births (of which 1,360 were twin) indicating that twin pregnancies did not receive more frequent or intensified antenatal care. The percentage of twin deliveries in hospitals varied from 25.3% in Mozambique to 63.0% in Kenya, and women with twin deliveries were between 5 and 27 percentage points more likely to deliver in hospitals compared to women with singleton live births; this difference was significant in 5 of the 8 countries (t test p < 0.05). The percentage of twin deliveries by cesarean section varied from 9% in Mozambique to 36% in Rwanda. The newborn mortality rate among twins, adjusted for maternal age and parity, was 4.6 to 7.2 times higher for twins compared to singletons in all 8 countries. Conclusions Despite the limited sample size and the limited number of clinically relevant services evaluated, our study provided evidence that mothers of twins receive insufficient care and that mortality in twin newborns is very high in Eastern and Southern Africa. Most countries have insufficient guidelines for the care of twins. While our data do not allow us to make a causal link between insufficient guidelines and insufficient care, they call for an assessment and reconceptualisation of policies to reduce the unacceptably high mortality in twins in Eastern and Southern Africa., Claudia Hanson and colleagues review national guidance available in Eastern and Southern African countries for the care of twin pregnancies, and use Demographic and Health Survey data from each country to assess current obstetric practices and outcomes for twins., Author summary Why was this study done? Recent publications have shown high mortality in twin pregnancies in low- and middle-income settings. Previous research, limited to a few countries in sub-Saharan Africa, suggested that twin pregnancies receive substandard care. Very little is known about the underlying reasons for substandard care provision, which constrains the development of specific interventions. We sought to assess factors behind substandard care—specifically country policies and guidelines underpinning the provision of care for twins—and the care provided, using the Demographic and Health Surveys data from 8 Eastern and Southern African countries. What did the researchers do and find? We mapped and reviewed national training materials, guidelines, and policies underpinning the provision of care. We also assessed antenatal and childbirth care provided to twins based on nationally representative surveys including 1,360 twin births out of 73,462 live births in Kenya, Malawi, Mozambique, Rwanda, Tanzania, Uganda, Zambia, and Zimbabwe. Three of 5 countries with national emergency obstetric care in-service training materials omitted a specific section for management of twin deliveries, while university-led pre-service trainings included twins consistently. None of the training materials, guidelines, or policies provided clear guidance on an additional number of antenatal visits for twin pregnancies, while 7 of the 8 countries recommended twins be delivered in hospitals providing comprehensive emergency obstetric care. The percentage of twin deliveries in hospitals varied from 25.3% in Mozambique to 63.0% in Kenya, and women with twin deliveries were between 5 and 27 percentage points more likely to deliver in hospitals compared to women with singletons. What do these findings mean? These findings suggest that the lack of specific national training materials, guidelines, and policies may be one reason for the suboptimal care provided to twin pregnancies, although our 2 findings of (i) substandard guidelines and (ii) substandard care cannot be linked formally. The findings call for more attention within national training materials, guidelines, and policies towards this high-risk group within the Sustainable Development Goal programming. Research is needed to investigate whether insufficient diagnosis of twin pregnancies, insufficient clinical guidance, or both critically affect care provision and are important beyond other demand side factors.