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3,763 results on '"Leenhardt, A."'

104. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome

Author

Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez Corcia, M. Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J.M., Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G., Hochstadt, Aviram, Wijeyeratne, Yanushi D., Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G., Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F., Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R., Wilde, Arthur A.M., Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, and Belhassen, Bernard

Published
2019
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106. Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia

Author

Lieve, Krystien V.V., Verhagen, Judith M.A., Wei, Jinhong, Bos, J. Martijn, van der Werf, Christian, Rosés i Noguer, Ferran, Mancini, Grazia M.S., Guo, Wenting, Wang, Ruiwu, van den Heuvel, Freek, Frohn-Mulder, Ingrid M.E., Shimizu, Wataru, Nogami, Akihiko, Horigome, Hitoshi, Roberts, Jason D., Leenhardt, Antoine, Crijns, Harry J.G., Blank, Andreas C., Aiba, Takeshi, Wiesfeld, Ans C.P., Blom, Nico A., Sumitomo, Naokata, Till, Jan, Ackerman, Michael J., Chen, S.R. Wayne, van de Laar, Ingrid M.B.H., and Wilde, Arthur A.M.

Published
2019
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107. NIFT-P: Are they indolent tumors? Results of a multi-institutional study

Author

Chereau, Nathalie, Greilsamer, Tristan, Mirallié, Eric, Sadowski, Samira M., Pusztaszeri, Marc, Triponez, Frederic, Baud, Grégory, Pattou, Francois, Christou, Niki, Mathonnet, Muriel, Brunaud, Laurent, Santucci, Nicolas, Goudet, Pierre, Guérin, Carole, Sebag, Frédéric, Donatini, Gianluca, Kraimps, Jean-Louis, Tissier, Frédérique, Lussey-Lepoutre, Charlotte, Leenhardt, Laurence, and Menegaux, Fabrice

Published
2019
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108. A neural network algorithm for detection of GI angiectasia during small-bowel capsule endoscopy

Author

Sacher-Huvelin, Sylvie, Mesli, Farida, Leandri, Chloé, Nion-Larmurier, Isabelle, Lecleire, Stéphane, Gerard, Romain, Duburque, Clotilde, Vanbiervliet, Geoffroy, Amiot, Xavier, Philippe Le Mouel, Jean, Delvaux, Michel, Jacob, Pierre, Simon-Shane, Camille, Romain, Olivier, Leenhardt, Romain, Vasseur, Pauline, Li, Cynthia, Saurin, Jean Christophe, Rahmi, Gabriel, Cholet, Franck, Becq, Aymeric, Marteau, Philippe, Histace, Aymeric, and Dray, Xavier

Published
2019
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111. Characteristics of specialists treating hypothyroid patients: the “THESIS” collaborative

Author

Žarković, Miloš, primary, Attanasio, Roberto, additional, Nagy, Endre V., additional, Negro, Roberto, additional, Papini, Enrico, additional, Perros, Petros, additional, Cohen, Chagit Adler, additional, Akarsu, Ersin, additional, Alevizaki, Maria, additional, Ayvaz, Göksun, additional, Bednarczuk, Tomasz, additional, Berta, Eszter, additional, Bodor, Miklos, additional, Borissova, Anna Maria, additional, Boyanov, Mihail, additional, Buffet, Camille, additional, Burlacu, Maria-Cristina, additional, Ćirić, Jasmina, additional, Díez, Juan J., additional, Dobnig, Harald, additional, Fadeyev, Valentin, additional, Field, Benjamin C. T., additional, Fliers, Eric, additional, Frølich, Jacob Stampe, additional, Führer, Dagmar, additional, Galofré, Juan Carlos, additional, Hakala, Tommi, additional, Jiskra, Jan, additional, Kopp, Peter, additional, Krebs, Michael, additional, Kršek, Michal, additional, Kužma, Martin, additional, Lantz, Mikael, additional, Lazúrová, Ivica, additional, Leenhardt, Laurence, additional, Luchytskiy, Vitaliy, additional, McGowan, Anne, additional, Melo, Miguel, additional, Metso, Saara, additional, Moran, Carla, additional, Morgunova, Tatyana, additional, Mykola, Tronko, additional, Beleslin, Biljana Nedeljković, additional, Niculescu, Dan Alexandru, additional, Perić, Božidar, additional, Planck, Tereza, additional, Poiana, Catalina, additional, Puga, Francisca Marques, additional, Robenshtok, Eyal, additional, Rosselet, Patrick, additional, Ruchala, Marek, additional, Riis, Kamilla Ryom, additional, Shepelkevich, Alla, additional, Unuane, David, additional, Vardarli, Irfan, additional, Visser, W. Edward, additional, Vrionidou, Andromachi, additional, Younes, Younes R., additional, Yurenya, Elena, additional, and Hegedüs, Laszlo, additional

Published
2023
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112. Type 3 long QT syndrome: is the effectiveness of treatment with beta-blockers population-specific?

Author

Hermida, Alexis, primary, Gourraud, Jean-Baptiste, additional, Denjoy, Isabelle, additional, Fressart, Véronique, additional, Kyndt, Florence, additional, Maltret, Alice, additional, Khraiche, Diala, additional, Klug, Didier, additional, Mabo, Philippe, additional, Sacher, Frédéric, additional, Maury, Philippe, additional, Winum, Pierre, additional, Defaye, Pascal, additional, Clerici, Gael, additional, Babuty, Dominique, additional, Elbez, Yedid, additional, Morgat, Charles, additional, Surget, Elodie, additional, Messali, Anne, additional, De Jode, Patrick, additional, Clédel, Aurélien, additional, Minois, Damien, additional, Maison-Blanche, Pierre, additional, Bloch, Adrien, additional, Leenhardt, Antoine, additional, Probst, Vincent, additional, and Extramiana, Fabrice, additional

Published
2023
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118. Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy: A Delphi Consensus Statement of the International CApsule endoscopy REsearch (I-CARE) Group

Author

Luca Elli, Beatrice Marinoni, Reena Sidhu, Christian Bojarski, Federica Branchi, Gian Eugenio Tontini, Stefania Chetcuti Zammit, Sherine Khater, Rami Eliakim, Emanuele Rondonotti, Jean Cristhophe Saurin, Mauro Bruno, Juliane Buchkremer, Sergio Cadoni, Flaminia Cavallaro, Xavier Dray, Pierre Ellul, Ignacio Fernandez Urien, Martin Keuchel, Uri Kopylov, Anastasios Koulaouzidis, Romain Leenhardt, Peter Baltes, Hanneke Beaumont, Clelia Marmo, Deirdre McNamara, Alessandro Mussetto, Artur Nemeth, Enrique Perez Cuadrado Robles, Guillame Perrod, Gabriel Rahmi, Maria Elena Riccioni, Alexander Robertson, Cristiano Spada, Ervin Toth, Konstantinos Triantafyllou, Gabriele Wurm Johansson, and Alessandro Rimondi

Subjects
small bowel atrophy, video-capsule enteroscopy, consensus, Medicine (General), R5-920
Abstract

(1) Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; (2) Methods: The Delphi technique was employed to reach agreement among a panel of SBCE experts. The nomenclature and definitions of SBCE lesions suggesting the presence of atrophy were decided in a core group of 10 experts. Four images of each lesion were chosen from a large SBCE database and agreement on the correspondence between the picture and the definition was evaluated using the Delphi method in a broadened group of 36 experts. All images corresponded to histologically proven mucosal atrophy; (3) Results: Four types of atrophic lesions were identified: mosaicism, scalloping, folds reduction, and granular mucosa. The core group succeeded in reaching agreement on the nomenclature and the descriptions of these items. Consensus in matching the agreed definitions for the proposed set of images was met for mosaicism (88.9% in the first round), scalloping (97.2% in the first round), and folds reduction (94.4% in the first round), but granular mucosa failed to achieve consensus (75.0% in the third round); (4) Conclusions: Consensus among SBCE experts on atrophic lesions was met for the first time. Mosaicism, scalloping, and folds reduction are the most reliable signs, while the description of granular mucosa remains uncertain.

Published
2022
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120. Differential Effect of Targeted Temperature Management Between 32 °C and 36 °C Following Cardiac Arrest According to Initial Severity of Illness

Author

Jean Baptiste Lascarrou, Florence Dumas, Wulfran Bougouin, Stephane Legriel, Nadia Aissaoui, Nicolas Deye, Frankie Beganton, Lionel Lamhaut, Daniel Jost, Antoine Vieillard-Baron, Graham Nichol, Eloi Marijon, Xavier Jouven, Alain Cariou, F. Adnet, J.M. Agostinucci, N. Aissaoui-Balanant, V. Algalarrondo, F. Alla, C. Alonso, W. Amara, D. Annane, C. Antoine, P. Aubry, E. Azoulay, F. Beganton, C. Billon, W. Bougouin, J. Boutet, C. Bruel, P. Bruneval, A. Cariou, P. Carli, E. Casalino, C. Cerf, A. Chaib, B. Cholley, Y. Cohen, A. Combes, J.M. Coulaud, D. Da Silva, V. Das, A. Demoule, I. Denjoy, N. Deye, J.L. Diehl, S. Dinanian, L. Domanski, D. Dreyfuss, J.L. Dubois-Rande, F. Dumas, J. Duranteau, J.P. Empana, F. Extramiana, J.Y. Fagon, M. Fartoukh, F. Fieux, E. Gandjbakhch, G. Geri, B. Guidet, F. Halimi, P. Henry, P. Jabre, L. Joseph, D. Jost, X. Jouven, N. Karam, J. Lacotte, K. Lahlou-Laforet, L. Lamhaut, A. Lanceleur, O. Langeron, T. Lavergne, E. Lecarpentier, A. Leenhardt, N. Lellouche, V. Lemiale, F. Lemoine, F. Linval, T. Loeb, B. Ludes, C.E. Luyt, N. Mansencal, N. Mansouri, E. Marijon, E. Maury, V. Maxime, B. Megarbane, A. Mekontso-Dessap, H. Mentec, J.P. Mira, X. Monnet, K. Narayanan, N. Ngoyi, M.C. Perier, O. Piot, P. Plaisance, B. Plaud, I. Plu, J.H. Raphalen, M. Raux, F. Revaux, J.D. Ricard, C. Richard, B. Riou, F. Roussin, F. Santoli, F. Schortgen, T. Sharshar, G. Sideris, C. Spaulding, J.L. Teboul, J.F. Timsit, J.P. Tourtier, P. Tuppin, C. Ursat, O. Varenne, A. Vieillard-Baron, S. Voicu, K. Wahbi, and V. Waldmann

Subjects
Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Published
2023
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124. Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Author

Barc, Julien, Tadros, Rafik, Glinge, Charlotte, Chiang, David Y., Jouni, Mariam, Simonet, Floriane, Jurgens, Sean J., Baudic, Manon, Nicastro, Michele, Potet, Franck, Offerhaus, Joost A., Walsh, Roddy, Choi, Seung Hoan, Verkerk, Arie O., Mizusawa, Yuka, Anys, Soraya, Minois, Damien, Arnaud, Marine, Duchateau, Josselin, Wijeyeratne, Yanushi D., Muir, Alison, Papadakis, Michael, Castelletti, Silvia, Torchio, Margherita, Ortuño, Cristina Gil, Lacunza, Javier, Giachino, Daniela F., Cerrato, Natascia, Martins, Raphaël P., Campuzano, Oscar, Van Dooren, Sonia, Thollet, Aurélie, Kyndt, Florence, Mazzanti, Andrea, Clémenty, Nicolas, Bisson, Arnaud, Corveleyn, Anniek, Stallmeyer, Birgit, Dittmann, Sven, Saenen, Johan, Noël, Antoine, Honarbakhsh, Shohreh, Rudic, Boris, Marzak, Halim, Rowe, Matthew K., Federspiel, Claire, Le Page, Sophie, Placide, Leslie, Milhem, Antoine, Barajas-Martinez, Hector, Beckmann, Britt-Maria, Krapels, Ingrid P., Steinfurt, Johannes, Winkel, Bo Gregers, Jabbari, Reza, Shoemaker, Moore B., Boukens, Bas J., Škorić-Milosavljević, Doris, Bikker, Hennie, Manevy, Federico, Lichtner, Peter, Ribasés, Marta, Meitinger, Thomas, Müller-Nurasyid, Martina, Veldink, Jan H., van den Berg, Leonard H., Van Damme, Philip, Cusi, Daniele, Lanzani, Chiara, Rigade, Sidwell, Charpentier, Eric, Baron, Estelle, Bonnaud, Stéphanie, Lecointe, Simon, Donnart, Audrey, Le Marec, Hervé, Chatel, Stéphanie, Karakachoff, Matilde, Bézieau, Stéphane, London, Barry, Tfelt-Hansen, Jacob, Roden, Dan, Odening, Katja E., Cerrone, Marina, Chinitz, Larry A., Volders, Paul G., van de Berg, Maarten P., Laurent, Gabriel, Faivre, Laurence, Antzelevitch, Charles, Kääb, Stefan, Arnaout, Alain Al, Dupuis, Jean-Marc, Pasquie, Jean-Luc, Billon, Olivier, Roberts, Jason D., Jesel, Laurence, Borggrefe, Martin, Lambiase, Pier D., Mansourati, Jacques, Loeys, Bart, Leenhardt, Antoine, Guicheney, Pascale, Maury, Philippe, Schulze-Bahr, Eric, Robyns, Tomas, Breckpot, Jeroen, Babuty, Dominique, Priori, Silvia G., Napolitano, Carlo, de Asmundis, Carlo, Brugada, Pedro, Brugada, Ramon, Arbelo, Elena, Brugada, Josep, Mabo, Philippe, Behar, Nathalie, Giustetto, Carla, Molina, Maria Sabater, Gimeno, Juan R., Hasdemir, Can, Schwartz, Peter J., Crotti, Lia, McKeown, Pascal P., Sharma, Sanjay, Behr, Elijah R., Haissaguerre, Michel, Sacher, Frédéric, Rooryck, Caroline, Tan, Hanno L., Remme, Carol A., Postema, Pieter G., Delmar, Mario, Ellinor, Patrick T., Lubitz, Steven A., Gourraud, Jean-Baptiste, Tanck, Michael W., George, Jr., Alfred L., MacRae, Calum A., Burridge, Paul W., Dina, Christian, Probst, Vincent, Wilde, Arthur A., Schott, Jean-Jacques, Redon, Richard, and Bezzina, Connie R.

Published
2022
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125. Should We Perform an Immediate Coronary Angiogram in All Patients After Cardiac Arrest?: Insights From a Large French Registry

Author

Adnet, F., Agostinucci, J.M., Aissaoui-Balanant, N., Albuisson, J., Algalarrondo, V., Alla, F., Annane, D., Antoine, C., Aubry, P., Azoulay, E., Beganton, F., Benhamou, D., Bougouin, W., Bruel, C., Cariou, A., Carli, P., Cerf, C., Chaib, A., Chastre, J., Cohen, Y., Combes, A., Cornaglia, C., Da Silva, D., Das, V., Demoule, A., Deye, N., Dhonneur, G., Diehl, J.L., Dinanian, S., Domanski, L., Dreyfuss, D., Duboc, D., Dubois-Rande, J.L., Dubourg, O., Duchateau, F.X., Dumas, F., Empana, J.P., Extramiana, F., Fagon, J.Y., Fartoukh, M., Fenioux, C., Fieux, F., Fraisse, F., Gabbas, M., Gandjbakhch, E., Guidet, B., Henry, P., Hidden Lucet, F., Jabre, P., Jacob, L., Joseph, L., Jost, D., Journois, D., Jouven, X., Karam, N., Kassim, H., Lahlou-Laforet, K., Lamhaut, L., Lanceleur, A., Langeron, O., Lanoe, V., Lecarpentier, E., Leenhardt, A., Lellouche, N., Lemiale, V., Linval, F., Loeb, T., Ludes, B., Maltret, A., Mansouri, N., Mantz, J., Marijon, E., Marty, J., Maury, E., Maxime, V., Mekontso-Dessaps, A., Mira, J.P., Monnet, X., Perier, M.C., Piot, O., Pirraccchio, R., Plu, I., Raux, M., Revaux, F., Ricard, J.D., Richard, C., Riou, B., Roussin, F., Santoli, F., Schortgen, F., Sharshar, T., Sideris, G., Spaulding, C., Teboul, J.L., Timsit, J.F., Tourtier, J.P., Tuppin, P., Ursat, C., Varenne, O., Vieillard-Baron, A., Voicu, S., Wahbi, K., Bougouin, Wulfran, Dumas, Florence, Karam, Nicole, Maupain, Carole, Marijon, Eloi, Lamhaut, Lionel, Jost, Daniel, Geri, Guillaume, Beganton, Frankie, Varenne, Olivier, Spaulding, Christian, Jouven, Xavier, and Cariou, Alain

Published
2018
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126. Development and Validation of Analytical Methods for Radiochemical Purity of 177Lu-PSMA-1

Author

Pauline Orhon, Marie-Dominique Desruet, Marie Piquemal, Nicolas De Leiris, Loïc Djaileb, Jean-Philippe Vuillez, Pierrick Bedouch, and Julien Leenhardt

Subjects
radioligand therapy, prostate cancer, radiochemical purity, 177Lu-PSMA-1, validation of analytical methods, high-performance liquid chromatography (HPLC), Medicine, Pharmacy and materia medica, RS1-441
Abstract

Prostate Specific Membrane Antigen (PSMA) is a highly relevant target in nuclear medicine due to its overexpression in prostate cancer. The 68Ga/177Lu-PSMA-1 combination is a theranostic agent for the detection and treatment of tumors overexpressing the PSMA target. Specifically, 177Lu-PSMA-1 is used in the treatment of castration-resistant prostate cancer that is ineffective or intolerant to the latest generation of chemotherapy and/or hormone therapy. This radiopharmaceutical is manufactured in a radiopharmaceutical synthesizing unit and must pass a quality control where the radiochemical purity (RCP) is assessed prior to release of the batch. RCP evaluation is performed by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC). Since there is no monograph for 177Lu-PSMA-1 in the European Pharmacopoeia, we validate the analytical methods according to the EANM recommendations adapted from ICH Q2. Specificity, linearity, accuracy, precision, intermediate precision, limit of quantification (LOQ) and robustness were described for HPLC and TLC in this study. The results obtained demonstrated the robustness and reliability of the HPLC and TLC analytical methods for the evaluation of the RCP of 177Lu-PSMA-1.

Published
2022
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127. Pharmacokinetic Variability Drives Palbociclib-Induced Neutropenia in Metastatic Breast Cancer Patients: Drug–Drug Interactions Are the Usual Suspects

Author

Fanny Leenhardt, Frédéric Fiteni, Ludovic Gauthier, Marie Alexandre, Séverine Guiu, Nelly Firmin, Stéphane Pouderoux, Marie Viala, Gerald Lossaint, Chloé Gautier, Caroline Mollevi, Matthieu Gracia, Celine Gongora, Litaty Mbatchi, Alexandre Evrard, and William Jacot

Subjects
clinical trial, oncology breast cancer, therapeutic drug monitoring, drug–drug interaction, Pharmacy and materia medica, RS1-441
Abstract

Palbociclib is a good candidate for therapeutic drug monitoring (TDM) due to its narrow therapeutic range and frequency of toxicities, particularly high-grade neutropenia. In this prospective, bicentric clinical trial, we evaluated the palbociclib exposure–toxicity relationship and determined the relevant sources of palbociclib pharmacokinetic variability, including drug–drug interactions (DDI). We followed 58 patients (mean age: 62.9 years) for 1 year. The geometric median of palbociclib plasma trough concentration (Ctrough) was 74.1 ng/mL. Neutropenia occurred in 70.7% of patients (high grade in 67.2% of patients). High-grade neutropenia occurrence during the first two palbociclib cycles was higher in patients with lower neutrophil count at initiation (p = 0.002). Palbociclib plasma Ctrough was correlated with high-grade neutropenia occurrence during the first two cycles (p = 0.024, OR 5.51). Co-treatment with agents that may interfere with palbociclib PK significantly influenced palbociclib Ctrough (p < 0.05). CYP3A4/P-glycoprotein inhibitors increased by 25% palbociclib Ctrough (p = 0.035), while antacids reduced it by 20% (p = 0.036). However, DDI did not have any significant effect on high-grade neutropenia occurrence (p > 0.05). This study confirms the major role of TDM to manage palbociclib safe use from the first week of treatment, particularly the significant incidence of hematological toxicity. Moreover, this first dedicated prospective study confirmed the importance of characterizing co-treatments to limit the DDI risk with oral-targeted therapies.

Published
2022
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130. Efficacy and safety of combination targeted therapies in immune-mediated inflammatory disease: the COMBIO study

Author

Lucas Guillo, Benoit Flachaire, Jérôme Avouac, Catherine Dong, Maria Nachury, Guillaume Bouguen, Anthony Buisson, Ludovic Caillo, Mathurin Fumery, Cyrielle Gilletta, Xavier Hébuterne, Pierre Lafforgue, David Laharie, Emmanuel Mahé, Hubert Marotte, Stéphane Nancey, Sébastien Ottaviani, Jean-Hugues Salmon, Guillaume Savoye, Mélanie Serrero, Mathieu Uzzan, Manuelle Viguier, Christophe Richez, Laurent Peyrin-Biroulet, Philipe Seksik, Thao Pham, Philippe Ah-Soune, Nadia Arab, Laurent Beaugerie, Loïs Bolko, Joelle Bonnet, Yoram Bouhnik, Anne Bourrier, Franck Brazier, Franck Carbonnel, Maeva Charkaoui, Isabelle Charlot-Lambrecht, Antoine Chupin, Alice Combier, Marion Couderc, Fabienne Coury-Lucas, Ariadne Desjeux, Nicolas Duveau, Anne Grasland, Jean-Charles Grimaud, Xavier Guennoc, Cécilia Landman, Isabelle Nion-Larmurier, Catherien Leberre, Romain Leenhardt, Aude Le Goffic, Henri Montaudie, Jacques Morel, Thierry Passeron, Jeanne-Marie Perotin Collard, Elodie Poisnel, Vincent Pradel, Martin Soubrier, Harry Sokol, Eric Toussirot, Caroline Trang, My-Linh Trans Minh, Sophie Trijau, Frank Verhoeven, Stéphanie Viennot, Daniel Wendling, Hôpital Nord [CHU - APHM], Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Nice (CHU Nice), Institut du Mouvement et de l’appareil Locomoteur [Hôpital Sainte-Marguerite - APHM] (IML), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )-Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Centre Hospitalier Victor Dupouy, Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Universitaire de Reims (CHU Reims), Vieillissement, Fragilité (VIEFRA - EA 3797), Université de Reims Champagne-Ardenne (URCA), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Beaujon [AP-HP], Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 (IRMAIC), Hôpital universitaire Robert Debré [Reims], Immunology from Concept and Experiments to Translation (ImmunoConcept), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Service de Rhumatologie [CHU Pellegrin], Groupe hospitalier Pellegrin, Centre National de Référence des Maladies Auto-Immunes Systémiques Rares de l'Est et du Sud-Ouest (RESO), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hôpital Charles Nicolle [Rouen]-CHU Rouen

Subjects
Adult, Cohort Studies, Immunomodulating Agents, Crohn Disease, Immune-mediated inflammatory diseases, Hepatology, Gastroenterology, Humans, Tumor Necrosis Factor Inhibitors, Ustekinumab, Molecular targeted therapy, Combination therapy, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; BACKGROUND: Use of a combination of targeted therapies (COMBIO) in patients with refractory/overlapping immune-mediated inflammatory diseases (IMIDs) has increased, but reported data remain scarce. We aimed to assess effectiveness and safety of COMBIO in patients with IMIDs. METHODS: We conducted a French ambispective multicenter cohort study from September 2020 to May 2021, including adults' patients with 1 or 2 IMIDs and treated at least 3-month with COMBIO. RESULTS: Overall, 143 patients were included. The most common IMIDs were Crohn's disease (63.6%), axial spondyloarthritis (37.7%), and ulcerative colitis (14%). Half of patients had only one IMID, of which 60% were Crohn's disease. Mean duration of COMBIO was 274.5±59.3 weeks, and COMBIO persistence at 104 weeks was estimated at 64.1%. The most frequent COMBIOs combined anti-TNF agents with vedolizumab (30%) or ustekinumab (28.7%). Overall, 50% of patients achieved significant and 27% mild-to-moderate improvement in patient-reported outcomes. Extended duration of COMBIO (aOR=1.09; 95% CI: 1.03-1.14; p=0.002) and diagnoses of two IMIDs (aOR=3.46; 95%CI: 1.29-9.26; p=0.013) were associated with significant improvement in patient-reported outcomes. Incidence of serious infection during COMBIO was 4.51 per 100 person-years (95% CI 2.20-8.27) and 5 COMBIOs were discontinued due to adverse events. CONCLUSIONS: COMBIO can be effective and safe in patients with refractory/overlapping IMIDs.

Published
2023
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131. Crossing the Dripline to 11N Using Elastic Resonance Scattering

Author

Markenroth, K., Axelsson, L., Baxter, S., Borge, M. J. G., Donzaud, C., Fayans, S., Fynbo, H. O. U., Goldberg, V. Z., Grevy, S., Guillemaud-Mueller, D., Jonson, B., Kallman, K. -M., Leenhardt, S., Lewitowicz, M., Lonnroth, T., Manngard, P., Martel, I., Mueller, A. C., Mukha, I., Nilsson, T., Nyman, G., Orr, N. A., Riisager, K., Rogachev, G. V., Saint-Laurent, M. -G., Serikov, I. N., Shul'gina, N. B., Sorlin, O., Steiner, M., Tengblad, O., Thoennessen, M., Tryggestad, E., Trzaska, W. H., Wenander, F., Winfield, J. S., and Wolski, R.

Subjects
Nuclear Experiment
Abstract

The level structure of the unbound nucleus 11N has been studied by 10C+p elastic resonance scattering in inverse geometry with the LISE3 spectrometer at GANIL, using a 10C beam with an energy of 9.0 MeV/u. An additional measurement was done at the A1200 spectrometer at MSU. The excitation function above the 10C+p threshold has been determined up to 5 MeV. A potential-model analysis revealed three resonance states at energies 1.27 (+0.18-0.05) MeV (Gamma=1.44 +-0.2 MeV), 2.01(+0.15-0.05) MeV, (Gamma=0.84 +-$0.2 MeV) and 3.75(+-0.05) MeV, (Gamma=0.60 +-0.05 MeV) with the spin-parity assignments I(pi) =1/2+, 1/2- and 5/2+, respectively. Hence, 11N is shown to have a ground state parity inversion completely analogous to its mirror partner, 11Be. A narrow resonance in the excitation function at 4.33 (+-0.05) MeV was also observed and assigned spin-parity 3/2-., Comment: 14 pages, 9 figures, twocolumn Accepted for publication in PRC

Published
2000
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134. The Halo of 14Be

Author

Labiche, M., Orr, N. A., Marques, F. M., Angelique, J. C., Axelsson, L., Benoit, B., Bergmann, U. C., Borge, M. J. G., Catford, W. N., Chappell, S. P. G., Clarke, N. M., Costa, G., Curtis, N., D'Arrigo, A., Brennand, E. de Goes, Dorvaux, O., Fazio, G., Freer, M., Fulton, B. R., Giardina, G., Grevy, S., Guillemaud-Mueller, D., Hanappe, F., Jones, B. Heusch K. L., Jonson, B., Brun, C. Le, Leenhardt, S., Lewitowicz, M., Lopez, M. J., Markenroth, K., Mueller, A. C., Nilsson, T., Ninane, A., Nyman, G., de Oliveira, F., Piqueras, I., Riisager, K., Laurent, M. G. Saint, Sarazin, F., Singer, S. M., Sorlin, O., and Stuttge, L.

Subjects
Nuclear Experiment
Abstract

The two-neutron halo nucleus 14Be has been investigated in a kinematically complete measurement of the fragments (12Be and neutrons) produced in dissociation at 35 MeV/nucleon on C and Pb targets. Two-neutron removal cross-sections, neutron angular distributions and invariant mass spectra characteristic of a halo were observed and the electromagnetic (EMD) contributions deduced. Comparison with three-body model predictions indicate that the halo wavefunction contains a large 2s1/2^2 admixture. The EMD invariant mass spectrum exhibited a relatively narrow structure near threshold (Edecay=1.8+/-0.1 MeV, Gamma = 0.8+/-0.4 MeV) consistent with a soft-dipole excitation., Comment: 17 pages, 3 figures

Published
2000

135. Tissue Infiltrating LTi—Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis

Author

Audrey Mohr, Christophe Trésallet, Natacha Monot, Adeline Bauvois, Delphine Abiven, Muhammad Atif, Laetitia Claër, Rajneesh Malhotra, Gaëll Mayer, Robert Balderas, Outi Vaarala, Gabrielle Deniziaut, Isabelle Brocheriou, Camille Buffet, Laurence Leenhardt, Guy Gorochov, and Makoto Miyara

Subjects
thyroid autoimmune disease, regulatory T cells, follicular helper T cells, lymphoid tissue–inducer-like cells, Hashimoto's thyroiditis, Graves' disease, Immunologic diseases. Allergy, RC581-607
Abstract

Background: Hashimoto's thyroiditis (HT) and Graves' disease (GD) are autoimmune thyroid disorders (AITDs). These conditions have been associated to abnormalities in circulating regulatory T cells (Tregs). We postulated that immune perturbations could be more pronounced at the thyroid tissue level.Methods: The phenotype of PBMCs and immune cells infiltrating thyroid tissue from 19 patients with HT, 21 patients with GD, and 30 controls has been analyzed by flow cytometry.Results: We report that blood and thyroid Treg cell subsets are similarly represented in all AITDs patients and controls. Increased Lymphoid tissue inducer (LTi)-like ILC3 and CXCR5+ PD-1hi CD4+ T follicular helper cells (Tfh) tissue-infiltrating cells, together with the prevalence of tertiary lymphoid structures (TLS) and germinal centers (GCs) represented a typical immune signature in all HT and 60% of GD patients. In the remaining group of GD patients, the absence of the aforementioned abnormalities was associated with a higher prevalence of ophthalmopathy.Conclusion: Tissue infiltrating Lymphoid Tissue inducer—like group 3 Innate Lymphoid cells and T follicular helper cells are increased in most thyroid autoimmune disease.

Published
2020
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136. CAD-CAP: a 25,000-image database serving the development of artificial intelligence for capsule endoscopy

Author

Romain Leenhardt, Cynthia Li, Jean-Philippe Le Mouel, Gabriel Rahmi, Jean Christophe Saurin, Franck Cholet, Arnaud Boureille, Xavier Amiot, Michel Delvaux, Clotilde Duburque, Chloé Leandri, Romain Gérard, Stéphane Lecleire, Farida Mesli, Isabelle Nion-Larmurier, Olivier Romain, Sylvie Sacher-Huvelin, Camille Simon-Shane, Geoffroy Vanbiervliet, Philippe Marteau, Aymeric Histace, and Xavier Dray

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and study aims Capsule endoscopy (CE) is the preferred method for small bowel (SB) exploration. With a mean number of 50,000 SB frames per video, SBCE reading is time-consuming and tedious (30 to 60 minutes per video). We describe a large, multicenter database named CAD-CAP (Computer-Assisted Diagnosis for CAPsule Endoscopy, CAD-CAP). This database aims to serve the development of CAD tools for CE reading. Materials and methods Twelve French endoscopy centers were involved. All available third-generation SB-CE videos (Pillcam, Medtronic) were retrospectively selected from these centers and deidentified. Any pathological frame was extracted and included in the database. Manual segmentation of findings within these frames was performed by two pre-med students trained and supervised by an expert reader. All frames were then classified by type and clinical relevance by a panel of three expert readers. An automated extraction process was also developed to create a dataset of normal, proofread, control images from normal, complete, SB-CE videos. Results Four-thousand-one-hundred-and-seventy-four SB-CE were included. Of them, 1,480 videos (35 %) containing at least one pathological finding were selected. Findings from 5,184 frames (with their short video sequences) were extracted and delimited: 718 frames with fresh blood, 3,097 frames with vascular lesions, and 1,369 frames with inflammatory and ulcerative lesions. Twenty-thousand normal frames were extracted from 206 SB-CE normal videos. CAD-CAP has already been used for development of automated tools for angiectasia detection and also for two international challenges on medical computerized analysis.

Published
2020
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138. High prevalence of ventricular repolarization abnormalities in people carrying TGFβR2 mutations

Author

F. Extramiana, O. Milleron, S. Elbitar, A. Uccellini, M. Langeois, M. Spentchian, G. Delorme, F. Arnoult, I. Denjoy, C. Bouleti, V. Fressart, F. Iserin, P. Maison-Blanche, M. Abifadel, A. Leenhardt, C. Boileau, and G. Jondeau

Subjects
Medicine, Science
Abstract

Abstract Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissection. The ECGs of the 2 Sudden Cardiac Deaths revealed profound ventricular repolarization abnormalities with a sinusoidal T-U morphology associated with normal left ventricular ejection fraction. These data strongly suggest sudden cardiac arrhythmic deaths and prompted us to systematically study the repolarization pattern in the patients with TGFβR2 mutations. ECG findings from 58 mutation carriers patients (TGFβR2 group) were compared with those of 46 non-affected first degree relatives (control group). TGFβR2 mutation was associated with ventricular repolarization abnormalities in 47% of patients (p

Published
2018
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143. Dysfunction of the Salivary and Lacrimal Glands After Radioiodine Therapy for Thyroid Cancer: Results of the START Study After 6-Months of Follow-Up

Author

Baudin, Clémence, primary, Bressand, Alice, additional, Buffet, Camille, additional, Menegaux, Fabrice, additional, Soret, Marine, additional, Lê, Anh Thu, additional, Cardon, Thomas, additional, Broggio, David, additional, Bassinet, Céline, additional, Huet, Christelle, additional, Armengol, Gemma, additional, Richardson, David B., additional, Leenhardt, Laurence, additional, Bernier, Marie-Odile, additional, and Lussey-Lepoutre, Charlotte, additional

Published
2023
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144. On the Use of Hydrological Models and Satellite Data to Study the Water Budget of River Basins Affected by Human Activities: Examples from the Garonne Basin of France

Author

Martin, Eric, Gascoin, Simon, Grusson, Youen, Murgue, Clément, Bardeau, Mélanie, Anctil, François, Ferrant, Sylvain, Lardy, Romain, Le Moigne, Patrick, Leenhardt, Delphine, Rivalland, Vincent, Pérez, José-Miguel Sánchez, Sauvage, Sabine, Therond, Olivier, Cazenave, A., editor, Champollion, N., editor, Benveniste, J., editor, and Chen, J., editor

Published
2016
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149. Radioactive iodine therapy, molecular imaging and serum biomarkers for differentiated thyroid cancer: 2017 guidelines of the French Societies of Nuclear Medicine, Endocrinology, Pathology, Biology, Endocrine Surgery and Head and Neck Surgery

Author

Zerdoud, Slimane, Giraudet, Anne-Laure, Leboulleux, Sophie, Leenhardt, Laurence, Bardet, Stéphane, Clerc, Jérôme, Toubert, Marie-Elisabeth, Al Ghuzlan, Abir, Lamy, Pierre-Jean, Bournaud, Claire, Keller, Isabelle, Sebag, Frédéric, Garrel, Renaud, Mirallié, Eric, Groussin, Lionel, Hindié, Elif, and Taïeb, David

Published
2017
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