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42,391 results on '"Lee, W."'

101. Towards Data Driven Dynamical System Discovery for Condition Monitoring a Reciprocating Compressor Example

Author

Smith, Ann, Lee, W. T., Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Zhang, Hao, editor, Feng, Guojin, editor, Wang, Hongjun, editor, Gu, Fengshou, editor, and Sinha, Jyoti K., editor

Published
2023
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103. Leveraging the COVID-19 pandemic as a natural experiment to assess changes in antibiotic use and antibiotic-resistant E. coli carriage in semi-rural Ecuador

Author

Heather K. Amato, Fernanda Loayza, Liseth Salinas, Diana Paredes, Daniela García, Soledad Sarzosa, Carlos Saraiva-Garcia, Timothy J. Johnson, Amy J. Pickering, Lee W. Riley, Gabriel Trueba, and Jay P. Graham

Subjects
Medicine, Science
Abstract

Abstract The coronavirus 2019 (COVID-19) pandemic has had significant impacts on health systems, population dynamics, public health awareness, and antibiotic stewardship, which could affect antibiotic resistant bacteria (ARB) emergence and transmission. In this study, we aimed to compare knowledge, attitudes, and practices (KAP) of antibiotic use and ARB carriage in Ecuadorian communities before versus after the COVID-19 pandemic began. We leveraged data collected for a repeated measures observational study of third-generation cephalosporin-resistant E. coli (3GCR-EC) carriage among children in semi-rural communities in Quito, Ecuador between July 2018 and September 2021. We included 241 households that participated in surveys and child stool sample collection in 2019, before the pandemic, and in 2021, after the pandemic began. We estimated adjusted Prevalence Ratios (aPR) and 95% Confidence Intervals (CI) using logistic and Poisson regression models. Child antibiotic use in the last 3 months declined from 17% pre-pandemic to 5% in 2021 (aPR: 0.30; 95% CI 0.15, 0.61) and 3GCR-EC carriage among children declined from 40 to 23% (aPR: 0.48; 95% CI 0.32, 0.73). Multi-drug resistance declined from 86 to 70% (aPR: 0.32; 95% CI 0.13; 0.79), the average number of antibiotic resistance genes (ARGs) per 3GCR-EC isolate declined from 9.9 to 7.8 (aPR of 0.79; 95% CI 0.65, 0.96), and the diversity of ARGs was lower in 2021. In the context of Ecuador, where COVID-19 prevention and control measures were strictly enforced after its major cities experienced some of the world’s the highest mortality rates from SARS-CoV-2 infections, antibiotic use and ARB carriage declined in semi-rural communities of Quito from 2019 to 2021.

Published
2023
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108. HAWC observations of the acceleration of very-high-energy cosmic rays in the Cygnus Cocoon

Author

Abeysekara, A. U., Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velazquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Blandford, R., Brisbois, C., Caballero-Mora, K. S., Capistran, T., Carraminana, A., Casanova, S., Cotti, U., de Leon, S. Coutino, De la Fuente, E., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Durocher, M., Diaz-Velez, J. C., Ellsworth, R. W., Engel, K., Espinoza, C., Fan, K. L., Fang, K., Fleischhack, H., Fraija, N., Galvan-Gamez, A., Garcia, D., Garcıa-Gonzalez, J. A., Garfias, F., Giacinti, G., Gonzalez, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hinton, J., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Huntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kieda, D., Lara, A., Lee, W. H., Vargas, H. Leon, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Martinez, O., Martinez-Castellanos, I., Martinez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Soto, J. A. Morales, Moreno, E., Mostafa, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Peisker, A., Araujo, Y. Perez, Perez-Perez, E. G., Ren, Z., Rho, C. D., Rosa-Gonzalez, D., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandova, A., Schneider, M., Schoorlemmer, H., Serna, F., Smith, A. J., Springer, R. W., Surajbali, P., Tollefson, K., Torres, I., Torres-Escobedo, R., Urena-Mena, F., Weisgarber, T., Werner, F., Willox, E., Zepeda, A., Zhou, H., on, C. De Le, and Alvarez, J. D.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Cosmic rays with energies up to a few PeV are known to be accelerated within the Milky Way. Traditionally, it has been presumed that supernova remnants were the main source of very-high-energy cosmic rays but theoretically it is difficult to get protons to PeV energies and observationally there simply is no evidence to support the remnants as sources of hadrons with energies above a few tens of TeV. One possible source of protons with those energies is the Galactic Center region. Here we report observations of 1-100 TeV gamma rays coming from the 'Cygnus Cocoon', which is a superbubble surrounding a region of OB2 massive star formation. These gamma rays are likely produced by 10-1000 TeV freshly accelerated CRs originating from the enclosed star forming region Cygnus OB2. Hitherto it was not known that such regions could accelerate particles to these energies. The measured flux is likely originated by hadronic interactions. The spectral shape and the emission profile of the Cocoon changes from GeV to TeV energies, which reveals the transport of cosmic particles and historical activity in the superbubble.

Published
2021
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109. Heading errors in all-optical alkali-vapor magnetometers in geomagnetic fields

Author

Lee, W., Lucivero, V. G., Romalis, M. V., Limes, M. E., Foley, E. L., and Kornack, T. W.

Subjects
Physics - Atomic Physics, Quantum Physics
Abstract

Alkali-metal atomic magnetometers suffer from heading errors in geomagnetic fields as the measured magnetic field depends on the orientation of the sensor with respect to the field. In addition to the nonlinear Zeeman splitting, the difference between Zeeman resonances in the two hyperfine ground states can also generate heading errors depending on initial spin polarization. We examine heading errors in an all-optical scalar magnetometer that uses free precession of polarized $^{87}\text{Rb}$ atoms by varying the direction and magnitude of the magnetic field at different spin polarization regimes. In the high polarization limit where the lower hyperfine ground state $F = 1$ is almost depopulated, we show that heading errors can be corrected with an analytical expression, reducing the errors by two orders of magnitude in Earth's field. We also verify the linearity of the measured Zeeman precession frequency with the magnetic field. With lower spin polarization, we find that the splitting of the Zeeman resonances for the two hyperfine states causes beating in the precession signals and nonlinearity of the measured precession frequency with the magnetic field. We correct for the frequency shifts by using the unique probe geometry where two orthogonal probe beams measure opposite relative phases between the two hyperfine states during the spin precession.

Published
2021
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110. HAWC Search for High-Mass Microquasars

Author

HAWC Collaboration, Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velazquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistran, T., Carraminana, A., Casanova, S., Cotti, U., Cotzomi, J., De la Fuente, E., de Leon, C., Hernandez, R. Diaz, Diaz-Velez, J. C., Dingus, B. L., Durocher, M., DuVernois, M. A., Ellsworth, R. W., Espinoza, C., Fan, K. L., Fang, K., Fraija, N., Galvan-Gamez, A., Garcia-Gonzalez, J. A., Garfias, F., Gonzalez, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Huntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kieda, D., Lara, A., Lee, J., Lee, W. H., Vargas, H. Leon, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Martinez, O., Martinez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafa, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Peisker, A., Araujo, Y. Perez, Rho, C. D., Roh, Y. J., Rosa-Gonzalez, D., Greus, F. Salesa, Sandoval, A., Schneider, M., Serna-Franco, J., Smith, A. J., Springer, R. W., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Urena-Mena, F., Villasenor, L., Watson, I. J., Weisgarber, T., Willox, E., and Zhou, H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Microquasars with high-mass companion stars are promising very-high-energy (VHE; 0.1-100 TeV) gamma-ray emitters, but their behaviors above 10 TeV are poorly known. Using the High Altitude Water Cherenkov (HAWC) observatory, we search for excess gamma-ray emission coincident with the positions of known high-mass microquasars (HMMQs). No significant emission is observed for LS 5039, Cygnus X-1, Cygnus X-3, and SS 433 with 1,523 days of HAWC data. We set the most stringent limit above 10 TeV obtained to date on each individual source. Under the assumption that HMMQs produce gamma rays via a common mechanism, we have performed source-stacking searches, considering two different scenarios: I) gamma-ray luminosity is a fraction $\epsilon_\gamma$ of the microquasar jet luminosity, and II) very-high-energy gamma rays are produced by relativistic electrons up-scattering the radiation field of the companion star in a magnetic field $B$. We obtain $\epsilon_\gamma < 5.4\times 10^{-6}$ for scenario I, which tightly constrains models that suggest observable high-energy neutrino emission by HMMQs. In the case of scenario II, the non-detection of VHE gamma rays yields a strong magnetic field, which challenges synchrotron radiation as the dominant mechanism of the microquasar emission between 10 keV and 10 MeV., Comment: Accepted for publication in ApJL

Published
2021
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111. Probing the Sea of Cosmic Rays by Measuring Gamma-Ray Emission from Passive Giant Molecular Clouds with HAWC

Author

Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Durocher, M., Díaz-Vélez, J. C., Ellsworth, R. W., Engel, K., Espinoza, C., Fan, K. L., Alonso, M. Fernández, Fraija, N., Galván-Gámez, A., Garcia, D., González, J. A. García-González F. Garfias M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Joshi, V., Kieda, D., Lara, A., Lee, W. H., Lee, J., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Martinez, O., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Omodei, N., Peisker, A., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E., Greus, F. Salesa, Sandoval, A., Schneider, M., Serna-Franco, J., Smith, A. J., Springer, R. W., Surajbali, P., Tanner, M., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Villaseñor, L., Weisgarber, T., Willox, E., Zhou, H., and de León, C.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The study of high-energy gamma rays from passive Giant Molecular Clouds (GMCs) in our Galaxy is an indirect way to characterize and probe the paradigm of the "sea" of cosmic rays in distant parts of the Galaxy. By using data from the High Altitude Water Cherenkov (HAWC) observatory, we measure the gamma-ray flux above 1 TeV of a set of these clouds to test the paradigm. We selected high-galactic latitude clouds that are in HAWC's field-of-view and which are within 1~kpc distance from the Sun. We find no significant excess emission in the cloud regions, nor when we perform a stacked log-likelihood analysis of GMCs. Using a Bayesian approach, we calculate 95\% credible intervals upper limits of the gamma-ray flux and estimate limits on the cosmic-ray energy density of these regions. These are the first limits to constrain gamma-ray emission in the multi-TeV energy range ($>$1 TeV) using passive high-galactic latitude GMCs. Assuming that the main gamma-ray production mechanism is due to proton-proton interaction, the upper limits are consistent with a cosmic-ray flux and energy density similar to that measured at Earth., Comment: 6 figures, 6 tables

Published
2021
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112. Evidence that Ultra-High-Energy Gamma Rays are a Universal Feature Near Powerful Pulsars

Author

HAWC Collaboration, Albert, A., Alfaro, R., Alvarez, C., Álvarez, J. D., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Durocher, M., Díaz-Vélez, J. C., Ellsworth, R. W., Engel, K., Espinoza, C., Fan, K. L., Alonso, M. Fernández, Fraija, N., Galván-Gámez, A., García-González, J. A., Garfias, F., Giacinti, G., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kieda, D., Lara, A., Lee, W. H., Lee, J., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Marandon, V., Martinez, O., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Peisker, A., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Roh, Y. J., Rosa-González, D., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Schoorlemmer, H., Serna-Franco, J., Smith, A. J., Springer, R. W., Surajbali, P., Tanner, M., Tollefson, K., Torres, I., Torres-Escobedo, R., Turner, R., Ureña-Mena, F., Villaseñor, L., Weisgarber, T., Willox, E., and Zhou, H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The highest-energy known gamma-ray sources are all located within 0.5 degrees of extremely powerful pulsars. This raises the question of whether ultra-high-energy (UHE; $>$ 56 TeV) gamma-ray emission is a universal feature expected near pulsars with a high spin-down power. Using four years of data from the High Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory, we present a joint-likelihood analysis of ten extremely powerful pulsars to search for UHE gamma-ray emission correlated with these locations. We report a significant detection ($>$ 3$\sigma$), indicating that UHE gamma-ray emission is a generic feature of powerful pulsars. We discuss the emission mechanisms of the gamma rays and the implications of this result. The individual environment that each pulsar is found in appears to play a role in the amount of emission., Comment: accepted by ApJL

Published
2021
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113. Spectrum and Morphology of the Very-High-Energy Source HAWC J2019+368

Author

HAWC Collaboration, Albert, A., Alfaro, R., Alvarez, C., Arteaga-Velàzquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., Brisbois, C., Caballero-Mora, K. S., Capistràn, T., Carramiñana, A., Casanova, S., Cotzomi, J., de León, S. Coutinõ, De la Fuente, E., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Durocher, M., Engel, K., Espinoza, C., Fraija, N., Garcia, D., García-González, J. A., Giacinti, G., González, M. M., Goodman, J. A., Harding, J. P., Hinton, J., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Huentemeyer, P., Jardin-Blicq, A., Joshi, V., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., López-Coto, R., Malone, K., Martinez, O., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Peisker, A., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-Gonzàlez, D., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Schoorlemmer, H., Serna-Franco, J., Smith, A. J., Springer, R. W., Surajbali, P., Tollefson, K., Torres, I., Turner, R., Urenã-Mena, F., Weisgarber, T., Willox, E., Zhou, H., and de León, C.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The MGRO J2019+37 region is one of the brightest sources in the sky at TeV energies. It was detected in the 2 year HAWC catalog as 2HWC J2019+367 and here we present a detailed study of this region using data from HAWC. This analysis resolves the region into two sources: HAWC J2019+368 and HAWC J2016+371. We associate HAWC J2016+371 with the evolved supernova remnant CTB 87, although its low significance in this analysis prevents a detailed study at this time. An investigation of the morphology (including possible energy dependent morphology) and spectrum for HAWC J2019+368 is the focus of this work. We associate HAWC J2019+368 with PSR J2021+3651 and its X-ray pulsar wind nebula, the Dragonfly nebula. Modeling the spectrum measured by HAWC and Suzaku reveals a $\sim$7 kyr pulsar and nebula system producing the observed emission at X-ray and ${\gamma}$-ray energies., Comment: Submitted to ApJ: 13 pages, 10 figures

Published
2021

114. Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men

Author

Martin, Ting, Romero, Tahmineh, Nickols, Nicholas G, Rettig, Matthew B, Garraway, Isla P, Roach, Mack, Michalski, Jeff M, Pisansky, Thomas M, Lee, W Robert, Jones, Christopher U, Rosenthal, Seth A, Wang, Chenyang, Hartman, Holly, Nguyen, Paul L, Feng, Felix Y, Boutros, Paul C, Saigal, Christopher, Chamie, Karim, Jackson, William C, Morgan, Todd M, Mehra, Rohit, Salami, Simpa S, Vince, Randy, Schaeffer, Edward M, Mahal, Brandon A, Dess, Robert T, Steinberg, Michael L, Elashoff, David, Sandler, Howard M, Spratt, Daniel E, and Kishan, Amar U

Subjects
Clinical Trials and Supportive Activities, Cancer, Prostate Cancer, Urologic Diseases, Clinical Research, Good Health and Well Being, Black People, Humans, Male, Prostatic Neoplasms, Randomized Controlled Trials as Topic, Treatment Outcome, White People
Abstract

ImportanceBlack men have a 2-fold increased risk of dying from prostate cancer compared with White men. However, race-specific differences in response to initial treatment remain unknown.ObjectiveTo compare overall and treatment-specific outcomes of Black and White men with localized prostate cancer receiving definitive radiotherapy (RT).Data sourcesA systematic search was performed of relevant published randomized clinical trials conducted by the NRG Oncology/Radiation Therapy Oncology Group between January 1, 1990, and December 31, 2010. This meta-analysis was performed from July 1, 2019, to July 1, 2021.Study selectionRandomized clinical trials of definitive RT for patients with localized prostate cancer comprising a substantial number of Black men (self-identified race) enrolled that reported on treatment-specific and overall outcomes.Data extraction and synthesisIndividual patient data were obtained from 7 NRG Oncology/Radiation Therapy Oncology Group randomized clinical trials evaluating definitive RT with or without short- or long-term androgen deprivation therapy. Unadjusted Fine-Gray competing risk models, with death as a competing risk, were developed to evaluate the cumulative incidences of end points. Cox proportional hazards models were used to evaluate differences in all-cause mortality and the composite outcome of distant metastasis (DM) or death. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed.Main outcomes and measuresSubdistribution hazard ratios (sHRs) of biochemical recurrence (BCR), DM, and prostate cancer-specific mortality (PCSM).ResultsA total of 8814 patients (1630 [18.5%] Black and 7184 [81.5%] White) were included; mean (SD) age was 69.1 (6.8) years. Median follow-up was 10.6 (IQR, 8.0-17.8) years for surviving patients. At enrollment, Black men were more likely to have high-risk disease features. However, even without adjustment, Black men were less likely to experience BCR (sHR, 0.88; 95% CI, 0.58-0.91), DM (sHR, 0.72; 95% CI, 0.58-0.91), or PCSM (sHR, 0.72; 95% CI, 0.54-0.97). No significant differences in all-cause mortality were identified (HR, 0.99; 95% CI, 0.92-1.07). Upon adjustment, Black race remained significantly associated with improved BCR (adjusted sHR, 0.79; 95% CI, 0.72-0.88; P

Published
2021

115. Extracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors

Author

Tonna, Joseph E., Boonstra, Philip S., MacLaren, Graeme, Paden, Matthew, Brodie, Daniel, Anders, Marc, Hoskote, Aparna, Ramanathan, Kollengode, Hyslop, Rob, Fanning, Jeffrey J., Rycus, Peter, Stead, Christine, Barrett, Nicholas A., Mueller, Thomas, Gómez, Rene D., Malhotra Kapoor, Poonam, Fraser, John F., Bartlett, Robert H., Alexander, Peta M.A., Barbaro, Ryan P., Abbasi, Adeel, Said Abdalmohsen, Ahmad, Abdelbary, Akram M., Abecasis, Francisco, Abel, Peter, Abu-Omar, Yasir, Adams, Douglas R, Manuel Africano, Juan, Aganga, Devon, Agati, Salvatore, Agerstrand, Cara, Aguillon, Mario V., Akers, Crystal S., Akhtarekhavari, Julia, Alazzam, Mohammad Izzat Salah, Albert, Martin, Alberti, Angela, Al-Fares, Abdulrahman A., Alfoudri, Huda, Allaert, Silvie, Allbert, Keesha N., Allen, Christopher T., Lescano Alva, Miguel Ángel, Alwardt, Cory M., Amigoni, Angela, Anandamurthy, Balaram, Anastasiadis, Kyriakos, Anders, Nicholas R., Anderson, Scott A., Anderson, Patricia L., Andrijević, Ana, Annoni, Alice, Anselmi, Michael, Anstey, James R., Antonini, Marta V., Antonitsis, Polychronis, Stein Araujo, Tays, Arcalas, Rhodney, Areinamo, Igor, Martin Arias, Anibal, Armijo-Garcia, Veronica, Aronsky, Vladimir, Arora, Lovkesh, Arora, Madhur, Leigh Aspenleiter, Marit, Atik, Fernando A., AugustGeorg Auzinger, Erin Colleen, Azzam, Ismail, Bacchetta, Matthew, Bak, Erica I., Balcells, Joan, Sánchez Ballesteros, Jesús, Banjac, Igor S., Barbaria, Jacqueline M., Barrigoto, Cleide L., Bass, Stephanie D., Batranović, Uroš, Bauer, Matthew H., Fernando Bautista, Diego, Beck, Robert M., Giraldo Bejarano, Estefania, Belohlavek, Jan, Bembea, Melania M., Benes, Jan, Benharash, Peyman, Benish, Lynne A., Bennett, Suzanne, Bento, Luís F.N., Bermudez, Christian A., Bertini, Pietro, Best, Derek, Bharat, Ankit, Bhutta, Omar J., Bizzell, Samantha J., Blakeman, Stephanie A., Blanco-Schweizer, Pablo, Blanton, Jessica K., Blood, Peggy S., Bohlmann, Allison S., Kyle Bohman, John, Bombino, Michela, Kathleen Bonadonna, Desiree, Bond, Ashley, Borgmann, Kristina M., Bourgoin, Pierre, Boville, Brian M., Boza, Raquel, Brady, Heather L., Brady, Alison, Braunlich, Jessica M., Bridges, Brian C., Brinkley, Karen K., Brookshire, Robert S., Brozzi Nicole Brueggemann, Nicolas A., Buckley, Dwight P., Jr., Buckley, Klayton, Budhani, Irfan B., Bukamal, Nazar, Burgos, Lucrecia M, Burša, Filip, Busby, Landon K., Buscher, Hergen, Butler, Menoly, Butt, Warwick W., Byrnes, Jonathan W., Calaritis, Christos, Caldwell, Lisa R., Calligaro, Gregory L., Campbell, Patrick T., Camporota, Luigi, Fernando Caneo, Luiz, Jovo Carapic, Vladimir, Carrasco-Carrasco, Cristina, Ivan Carrizo, Nestor, Carrow, Heidi, Carton, Edmund G., Casabella, Christian, Gomez Casal, Vanesa, Casey, Francis L., III, Castillo, Andres, Castleberry, Anthony W., Alexandros Cavayas, Yiorgos, Cerqua, Karey, Ming Chan, Kai Man ChanWai, Brian Chapman, Jason, Brahma Chari, Hari, Cheifetz, Omair ChaudharyIra M., Chen, Robin H.S, Chen, Weiting, Cheung, Eva W., Cheung, Anson, Chico, Juan I., Chiletti, Roberto, Jin Cho, Hwa, Cholette, Jill M., Christensen, Steffen, Chui, Betty S., Circelli, Alessandro, Clement, Katherine C., Cleuziou, Julie, Clouse, Brian, Cole, Gwendolen, Coles, Garrett M., Collins, Monika F., Collins, Monika F., Connelly, James, Conrad, Steven A., Cook, Marlene, Copeland, Hannah, Copus, Scott C., Cox, Charles S., Jr, Craig, Lynne K., Crain, Natasha, Cremonese, Ricardo V., Criswell, Emily A., Cross, Lisa M., Crowley, Moira A., Crowley, Jerome C., Cruz, Leonora, Cypel, Marcelo, Czarnik, Tomasz, Czuczwa, Miroslaw E., Sica da Rocha, Taís, Daddow, Samuel, Dali, Dante C., Dalton, Heidi J., Daly, Kathleen J.R., Damuth, Emily, Daniel, Dennis A., Daniel IV, John M., Daniel, Josiane M., Danis, Max D., Danko, Melissa E., Rodrigues Dantas, Joao Alberto, Daoust, Isabelle, Dauwe, Dieter F., Davidson, Mark, Davis, Joel C., Davis, Mitchell, D’Cunha, Jonathan, de Arruda Bravim, Bruno, de BoodeKim T. De La Cruz, Willem P., Gray DeAngelis, Kathryn, Debeuckelaere, Gerdy, Deitemyer, Matthew A., DellaVolpe, Jeffrey, Deneau, Jamie L., DeNino, Walter F., Denmark, Christopher G., Denney, Derek, DeValeria, Patrick A., Dewulf, Petra, Di Nardo, Matteo, DiBardino, Daniel J., DiMartino, Joseph, Dimopoulos, Stavros, Domico, Michele B., Dominy, Meaghan E., Donker, Dirk W., Dresbach, Till, Droogh, Joep M., Dunlap, Tiffany W., Dupon, Allsion, Durham, Lucian A., III, Durward, Andrew, Dvorak, Anna, Dyett, John F., Dziedzina, Carol L., Eaken, Carmen L., Eaton, Jonathan S., Eberle, Christopher J., Edwards, Linda, Efseviou, Christakis, Eigner, Juliann M., Ahmed Elhamrawi, Hazem, Elhazmi, Alyaa M., Elizondo, Tammy, Ellersick, Beverly L., Emling, Jonathan A., Ernst, Andreas, Pablo Escalante, Juan, Espinoza, Otoniel, Evey, Lee W., Fan, Eddy, Fang, Gary, Faulkner, Gail M., Fauman, Karen R, Ferguson, Niall, Ferreira, Benigno, Fiane, Arnt E., Andrade Fierro, Dario, Martha Filippi, María, Findeisen, Michael C., Finlay, Katie, Finlayson, Gordon, Fischer, Gwenyth A., Fischer, Courtney D., Fischer, William J., III, Fisher, Caleb M., Fitriasari, Reni, Fitzgerald, Jillian, Fix, Melissa K., Fleming, Sarah B., Flynn, Brigid C., Forst, Beth A., Fortuna, Philip P., Foti, Giuseppe, Fox, Matthew P., Franco, Thais O., David Freeland, C., Fried, Justin A., Friedman, Matthew L., Furlanetto, Beatriz, Fux, Thomas, Gaião, Sérgio, Gale, Michael J., Garcia, Joann Kathleen G., Garcia-Montilla, Romel, Gardner, Eric R., Garg, Meena, Garrison, Lawrence L., Gavrilovic, Srdjan M., Gawda, Ryszard, Geer, Laura W., Gelandt, Elton A., Gelvin, Michael G., Genovese, Bradley M., George, Jeffrey A., George, Timothy J, George, Sangley, Ghimire, Anup, Giani, Marco, Gill, Baljit S., Glikes, Erin, Golecki, Michael, Gongora, Enrique, Govener, Sara, Graf, Amanda, Grasselli, Giacomo, Gray, Brian W., Greenlee, Joseph A., III, Gregoric, Igor D., Gregory, Melinda, Grins, Edgars, Volker Groesdonk, Heinrich, Group, Kimberly F., Guarracino, Fabio, Joy Guidi-Solloway, Alexandra, Gunn, Tyler M., Guru, Pramod K, Haddle, John C., Haft, Jonathan W., Haisz, Emma, Hall, Julie L., Hall, Cameron, Hamaguchi, Jun, Hammond, Terese C., Han, Peggy K., Hardison, Daphne C., Harischandra, Dickwelle T., Hart, Shaun M., Harting, Matthew T., Hartley, Louise, Harvey, Chris J., Hasan, Zubair, Fawzy Hassan, Ibrahim, Hastings, Jennifer R., Hatcher, Renee’, Hatton, Kevin W., Haught, Christopher K., Awori Hayanga, Jeremiah, Peter Haydon, Timothy, Healy, Aaron H., Heard, Micheal L., Heather, Beth M., Hendrix, Rik H.J., Hennig, Felix, Hermens, Greet HermansJeannine A.J., Hernandez, Deborah A., Hernandez-Montfort, Jaime, Herrera, Guillermo, Hickman, Keri, Hittel, Ashley, Hobbs, Crystal, Hoffman, Jordan R.H., Hollinger, Laura E., Homishak, Michael, Horigoshi, Nelson K., Hoshino, Kota, Huang, Shu-Chien, Huenges, Katharina, Hussey, Alexander D., Hyslop, Robert W., Ihle, Rayan E., Ingemansson, Ola, Ivulich, Daniel, Jackson, Amanda L., Garcia Jacques, Rogelio, Jain, Harsh, Jakobs, Sharon M., Jan, Robert, Janowiak, Lisa M., Jara, Claire B., Jarden, Angela M., Jarzembowski, Jamie L., Jaudon, Andrew, Kishore Jayanthi, Venkata Krishna, Jennings, Joseph A., Jeong, Inseok, Meza Jiménez, Rafael, Jimenez-Rodriguez, Gian M., Joachim, Sabrina, Joelsons, Daniel, Johnson, Caroline A., Johnson, Andrea L., Jones, Jeffry H., Joseph, Mark, Joseph, Sunimol, Joshi, Raja, Joyce, Christopher J., Seung Jung, Jae, Carone Junior, José, Kallas, Harry J., KamerkarPilje Kang, Asavari, Kar, Biswajit, Karapanagiotidis, Georgios T., Kattan, Javier, Kaufman, David A., Kawauchi, Akira, Keene, Sarah D., Keller, Norma M., Keller, Roberta, Kelley, Emily W., Kelley, Kellie, Kelly-Geyer, Janet F., Kenderessy, Peter, Kenny, Laura E., Keshavjee, Shaf, Kessel, D., Kessler, Heather, Keuler, Suzanne, Khicha, Sanjay, Wan Kim, Do, Kim, Richard Y., Maxwell Kime, Aaron, Kincade, Robert C., Kipfmueller, Florian, Kirk, Douglas A., Klein, Liviu, Knapp, Randall S., Knapp, Randall S., Kneyber, Martin C.J., Knowles, Andrea L., Koch, Jillian M., Koepke, Stephanie, Kogelmann, Klaus M., Elzo Kraemer, Carlos, Krauklis, Amanda, Krumroy, Samantha L., Kumar, Madhan, Kumar, Arun, Kumpf, Matthias E, Kyle, Kimberly, Laffin, Anna, Kees Lagrand, Wim, Lahiji, Parshawn A., Keung Lai, Peter Chi, Ka Lai, Cally Ho, Danielle Laird, Amanda, Landsberg, Michelle LaMarreDavid M., Lanmueller, Pia, Oude Lansink-Hartgring, Annemieke, Beth Larson, Sharon, Laufenberg, De’Ann M., Lavana, Jayshree, Layne, Tracie L., John Lazar, Michael, Ledoux, Matthew R., Lee, Raymond C., Leek, Thomas M., Lequier, Laurance, Lesbekov, Timur, Leslie, Robert, Anne Leung, Kit Hung, Lillie, Jon, Phang Lim, Yeong, Lim, Sang-Hyun, Lin, Ling, Lindsey, Thomas, Ho Ling, Steven Kin, Lingle, Kaitlyn J., Lipes, Jed, Liu, Songqiao, Llevadias, Judit, Lomas, Erin A., Longenecker, Robert D., Lorusso, Roberto, Ann Low, Tracy, Steven Lubinsky, Anthony, Lucas, Matthias LubnowMark T., Lucchini, Alberto, Luze, Lisa E., Lynch, William R., Manoj, M.C., Maas, Jacinta J., MacNamara, Vanessa, Madden, Jesse L., Maimone, Justin, Malhotra, Rajiv, Malone, Matthew P., Mangukia, Chirantan, Manzur-Sandoval, Daniel, Maráczi, Veronika, Marinaro, Jonathan L., Marinucci, Christina R., Marshall, Tammy, Martin, Mark, Marwali, Eva M., Maslach-Hubbard, Anna, Matijašević, Jovan, Mattke, Adrian, Mattucci, Joseph, Maul, Timothy M., Maybauer, Marc O., Mayette, Michael, Mayville, Joni R., McAllister, Catherine, McBride, Martha W., Scott McCaul, David, McClelland, Samantha L.S., Gregory McCloskey, Colin, McGregor, Randy, McKamie, Wesley A., McKee, Andrew D., McMahon, Chelsea M., McMullin, Kaye, McNicol, Jane, McNulty, John P., McRae, Thomas, Meade, Maureen E., Meersseman, Philippe, Mekeirele, Michael, Ito Mendes, Elisa, Menon, Anuradha P., Meyer, Jason P., Meyers, Jourdan E., Meyns, Bart, Mignone, John L., Miller, Brittany D., Miller, Malcolm G.A., Miller, Deborah, Mintak, Renee, Minter, Sarah M., Reis Miranda, Dinis, Mirza, Farrukh, Mishkin, Joseph D., Modelewski, Paul, Mohan, Rajeev C., Hui Mok, Yee, Money, Dustin, Monteagudo, Julie, Moores, Russell R., Jr., Moran, Patrick, Morelock, Shawn, Moreno, Marsha R., Blanco Morillo, Juan, Morrison, Tracy, Morton, John M., Morton, Brenda, Moscatelli, Andrea, Mosier, Jarrod M., Muellenbach, Ralf M., Mueller, Andreas, Mueller, Dale, Musca, Steven C., Nagpal, Dave, Najaf, Tasnim, Narasimhan, Mangala, Nater, Melissa, Natividad, Zynthia, Nedeljkov, Djordje, Nelson, Bryan D., Newman, Sally F., Newton, Debra E., Neyman, Jonathan L., George Ng, Wing Yiu, Nicholson, Meghan C., Nicolaas, Christine, Nix, Charlie, Nkwantabisa, Raymond, Nolan, Shirley, Norese, Mariano, Norton, Bridget M., Norton, Bridget M., O’Brien, Serena G., O’Callaghan, Maura, Oishi, Peter, O’Leary, Tony D., Olia, Salim E., O’Meara, Carlisle, Oppel, Emily E., Arias Ortiz, Julian, Oza, Pranay L., Ozment, Caroline P., Pacific, Marjorie, Pálizas, Fernando, Palmer, David, Paoletti, Luca, Pardo, Diego H., Paredes, Pablo, Patel, Thomas PasgaardMrunal G., Patel, Sandeep M., Patel, Vijay S., Patel, Brijesh V., PatelDrisya Paul, Sameer, Pawale, Amit A., Pearson, Nicole M., Renee Pearson, Crystal, Peek, Giles J., Pellecchia, Crescens M., Pellegrino, Vincent, Peperstraete, Harlinde, Perkins, Rebecca L., Perkins, Brandon, Peterec, Steven, Peterman, Claire, Phillips, Cooper W., Piekutowski, Richard R., Pilan, María L., Luisa Pilan, Maria, Mark Pincus, Jason, Pino, Melissa, Plambeck, Robert W., Plisco, Michael S., Plumley, Donald A., Plunkett, Mark D., Poffo, Robinson, Poh, Pei-Fen, Polito, Angelo, Pollema, Travis L, Pozzi, Matteo, Pozzi, Matteo, Pranikoff, Thomas, Prekker, Matthew E., Prossen, Erik F., Puligandla, Pramod S., Puslecki, Mateusz, Raheel Qureshi, Muhammad, Emilia Rabanal, Lily, Abdulhamid Rabie, Ahmed, Rackley, Craig R., Radovancevic, Rajko, Raes, Matthias, Allen Raff, Lauren Desiree, Rahban, Youssef, Raimer, Patricia L., Rajbanshi, Bijoy G., Ramanan, Raj, Rambaud, Jerome, Ramírez-Arce, Jorge A., Simões Ramos, Ana Carolina, Rao, Suresh G., Rector, Raymond, Redfors, Bengt, Regmi, Ashim, Alejandro Rey, Jose, Miguel Ribeiro, Joao, Richards, Chelsea E, Joan Richardson, C., Riddle, Christy C., Riera, Jordi, Ripardo, Marina, Rivas, Fernando M., Roan, Ronald M., Robertson, Elizabeth, Robinson, Megan, Röder, Daniel, Rodrigus, Inez E.R., Paul Roeleveld, Peter, Romano, Jennifer C., Rona, Roberto, Ann Rosenberg, Carol, Rosenow, Felix, Rowe, Robert J., Rower, Katy E., Rudolph, Kristina L., Fernando Rueda, Luis, Ruf, Bettina, Russell, Hyde M., Russell, Nichole, Ryan, Kathleen, Saberi, Asif A., Said, Ahmed S., Sailor, Caitlin, Sakal, Angela, Lujan Salas, Gisela, Salazar, Leonardo, Saleem, Kashif, Samoukovic, Gordan, Sanchez, Pablo G., Marie Santiago, Lian, Sargin, Murat, Miguel Sassine, Assad, Satou, Nancy L., Saunders, Paul C., Schachinger, Scott, Schaible, Thomas, Schellongowski, Peter, Schlager, Gerald W., Schmid, Christof, Schmitt, Joachim, Schnell, LeeAndra, Schnur, Janos, Schroeder, Lukas, Schubach, Scott, Schuetz, Michael T., Schwartz, Gary S., Schwarz, Patricia, Scriven, Nicole M., Seabrook, Ruth B., Seefeldt, Cassandra, Seelhammer, Troy G., Segura-Matute, Susana, Sen, Ayan, Adrian Seoane, Leonardo, Shaffer, Jamie, Shafi, Bilal M., Shambley, Shannon, Shankar, Shyam, Shapland, Amanda, Sharng, Yih, Shavelle, David, Sheldrake, Jayne, Mohan Shetty, Rajesh, Shiber, Joseph R., Shimzu, Naoki, Lou Short, Billie, Sichting, Kay A., Sidehamer, Keith E., Siebenaler, Teka, Silvestry, Scott C., Sinclair, Jennifer T, Sinclair, Andrew, Singh, Aalok R., Singh, Gurmeet, Skinner, Sean C., Smart, Alexandra, Smith, Reanna M., Smith, Adam, Smith, Karen, Sommer-Candelario, Sherri, Song, Seunghwan, Sorensen, Gro, Sousa, Eduardo, Sower, Christopher T., Spadea, Nicholas V, Spangle, April, Speicher, David G., Spieth, Peter M., Srivastava, Ankur, Srivastava, Neeraj, Stahl, Mark, Stallkamp, Eric D., Jr, Stanley, Vanessa J., Starr, Joanne P., Staudinger, Thomas, Stevens, Berkeley E., Stevens, Kimberly, Stocker, Christian, Strickland, Richard, Suarez, Erik E., Kumar Subramanian, Rakesh, Sudakevych, Serhii, Summerall, Charlene, Sundararajan, Santosh, Susupaus, Attapoom, Suzuki, Hiroyuki, Sweberg, Todd, Sydzyik, Troy, Anh Ta, Tuan, Tagliari, Luciana, Tanaka, Hiroyuki, Tanski, Christopher T., Tasset, Mark, Taylor, Donna M., Teman, Nicholas R., Ramesh Thangaraj, Paul, Thiagarajan, Ravi R., Thiruchelvam, Timothy, Thomas, James A., Thomas, Owain D., Thompson, Shaun L., Thomson, David A., Thukaram, Roopa, Todd, Mark L., Toeg, Hadi, Torres, Silvio F., Trautner, Simon, Trombino, Terry, Tuazon, Divina M., Tuel, Julie, Tukacs, Monika, Turner, April N., Tyree, Melissa M., Uchiyama, Prashant Vaijyanath, Makoto, van den Brule, Judith M.D., van Dyck, Marlice A., van Gijlswijk, Mascha, Van Meurs, Krisa P., VanDyck, Tyler J., Vardi, Amir, Vega, Alejandra, Ventetuolo, Corey E., Vera, Magdalena, Vercaemst, Leen, Vets, Philippe, Viamonte, Heather, Vidlund, Mårten, Vitali, Sally H., Vlaa, Alexander P.J., Vuylsteke, Alain, Loon Wan, Kah, Watkins, Reuben, Watson, Pia, Weast, Travis A., Weaver, Karen E., Welkovics, Norbert, Wellner, Heidi L., Wells, Jason C., Welter, Karen, Westpheling, Amber G., Whalen, Lesta D.S., Whebell, Stephen, Wiersema, Ubbo, Wiisanen, Matthew E., Eugene Wilcox, Bradley, Wille, Keith, Jan Will, Ellyne, Wilson, Brock J., Win, April M., Winearls, James R., Wise, Linda J., Witter, Tobias, Ruby Wong, Hoi Mei, Worku, Berhane, Wright, Tina M, Wu, James K., Yalon, Larissa A., Yantosh, Garrett, Yaranov, Dmitry M., Yee, Pat, Yi, Cassia, Yost, Christian C., Young, John, Younger, Katrina, Zaborowski, Steven, Zachmann, Brenda, Zainab, Asma, Zanai, Rosanna, Zhao, Ju, Zhou, Chengbin, and Zinger, Marcia

Published
2024
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117. Evidence of 200 TeV photons from HAWC J1825-134

Author

Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., De la Fuente, E., Hernandez, R. Diaz, Dingus, B. L., DuVernois, M. A., Durocher, M., Díaz-Vélez, J. C., Engel, K., Espinoza, C., Fang, K., Fleischhack, H., Fraija, N., Galván-Gámez, A., Garcia, D., García-González, J. A., Garfias, F., Giacinti, G., González, M. M., Goodman, J. A., Harding, J. P., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kunde, G. J., Lara, A., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Marandon, V., Martinez, O., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Omodei, N., Peisker, A., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Serna, F., Springer, R. W., Tollefson, K., Torres, I., Torres-Escobedo, R., Ureña-Mena, F., Villaseñor, L., Willox, E., Zhou, H., and de León, C.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Earth is bombarded by ultra-relativistic particles, known as cosmic rays (CRs). CRs with energies up to a few PeV (=10$^{15}$ eV), the knee in the particle spectrum, are believed to have a Galactic origin. One or more factories of PeV CRs, or PeVatrons, must thus be active within our Galaxy. The direct detection of PeV protons from their sources is not possible since they are deflected in the Galactic magnetic fields. Hundred TeV $\gamma$-rays from decaying $\pi^0$, produced when PeV CRs collide with the ambient gas, can provide the decisive evidence of proton acceleration up to the knee. Here we report the discovery by the High Altitude Water Cherenkov (HAWC) observatory of the $\gamma$-ray source, HAWC~J1825-134, whose energy spectrum extends well beyond 200 TeV without a break or cutoff. The source is found to be coincident with a giant molecular cloud. The ambient gas density is as high as 700 protons/cm$^3$. While the nature of this extreme accelerator remains unclear, CRs accelerated to energies of several PeV colliding with the ambient gas likely produce the observed radiation., Comment: Accepted for publication in ApJL

Published
2020
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118. Comparison of $pp$ and $p \bar{p}$ differential elastic cross sections and observation of the exchange of a colorless $C$-odd gluonic compound

Author

Abazov, V. M., Abbott, B., Acharya, B. S., Adams, M., Adams, T., Agnew, J. P., Alexeev, G. D., Alkhazov, G., Alton, A., Alves, G. A., Antchev, G., Askew, A., Aspell, P., Jesus, A. C. S. Assis, Atanassov, I., Atkins, S., Augsten, K., Aushev, V., Aushev, Y., Avati, V., Avila, C., Badaud, F., Baechler, J., Bagby, L., Barrera, C. Baldenegro, Baldin, B., Bandurin, D. V., Banerjee, S., Barberis, E., Baringer, P., Barreto, J., Bartlett, J. F., Bassler, U., Bazterra, V., Bean, A., Begalli, M., Bellantoni, L., Berardi, V., Beri, S. B., Bernardi, G., Bernhard, R., Berretti, M., Bertram, I., Besanccon, M., Beuselinck, R., Bhat, P. C., Bhatia, S., Bhatnagar, V., Blazey, G., Blessing, S., Bloom, K., Boehnlein, A., Boline, D., Boos, E. E., Borchsh, V., Borissov, G., Borysova, M., Bossini, E., Bottigli, U., Bozzo, M., Brandt, A., Brandt, O., Brochmann, M., Brock, R., Bross, A., Brown, D., Bu, X. B., Buehler, M., Buescher, V., Bunichev, V., Burdin, S., Burkhardt, H., Buszello, C. P., Cafagna, F. S., Camacho-P'erez, E., Carvahlo, W., Casey, B. C. K., Castilla-Valdez, H., Catanesi, M. G., Caughron, S., Chakrabarti, S., Chan, K. M., Chandra, A., Chapon, E., Chen, G., Cho, S. W., Choi, S., Choudhary, B., Cihangir, S., Claes, D., Clutter, J., Cooke, M., Cooper, W. E., Corcoran, M., Couderc, F., Cousinou, M. -C., Csan'ad, M., Cs"orgHo, T., Cuth, J., Cutts, D., Das, A., Davies, G., Deile, M., de Jong, S. J., De La Cruz-Burelo, E., De Leonardis, F., D'eliot, F., Demina, R., Denisov, D., Denisov, S. P., Desai, S., Deterre, C., DeVaughan, K., Diehl, H. T., Diesburg, M., Ding, P. F., Dominguez, A., Doubek, M., Drutskoy, A., Druzhkin, D., Dubey, A., Dudko, L. V., Duperrin, A., Dutt, S., Eads, M., Edmunds, D., Eggert, K., Ellison, J., Elvira, V. D., Enari, Y., Eremin, V., Evans, H., Evdokimov, A., Evdokimov, V. N., Faur'e, A., Feng, L., Ferbel, T., Ferro, F., Fiedler, F., Fiergolski, A., Filthaut, F., Fisher, W., Fisk, H. E., Forthomme, L., Fortner, M., Fox, H., Franc, J., Fuess, S., Garbincius, P. H., Garcia, F., Garcia-Bellido, A., Garc'ia-Gonz'alez, J. A., Gavrilov, V., Geng, W., Georgiev, V., Gerber, C. E., Gershtein, Y., Giani, S., Ginther, G., Gogota, O., Golovanov, G., Grannis, P. D., Greder, S., Greenlee, H., Grenier, G., Gris, Ph., Grivaz, J. -F., Grohsjean, A., Gr"unendahl, S., Gr"unewald, M. W., Grzanka, L., Guillemin, T., Gutierrez, G., Gutierrez, P., Haley, J., Hammerbauer, J., Han, L., Harder, K., Harel, A., Hauptman, J. M., Hays, J., Head, T., Hebbeker, T., Hedin, D., Hegab, H., Heinson, A. P., Heintz, U., Hensel, C., La Cruz, I. Heredia-De, Herner, K., Hesketh, G., Hildreth, M. D., Hirosky, R., Hoang, T., Hobbs, J. D., Hoeneisen, B., Hogan, J., Hohlfeld, M., Holzbauer, J. L., Howley, I., Hubacek, Z., Hynek, V., Iashvili, I., Ilchenko, Y., Illingworth, R., Isidori, T., Ito, A. S., Ivanchenko, V., Jabeen, S., Jaffr'e, M., Janda, M., Jayasinghe, A., Jeong, M. S., Jesik, R., Jiang, P., Johns, K., Johnson, E., Johnson, M., Jonckheere, A., Jonsson, P., Joshi, J., Jung, A. W., Juste, A., Kajfasz, E., Karev, A., Karmanov, D., Kavspar, J., Katsanos, I., Kaur, M., Kaynak, B., Kehoe, R., Kermiche, S., Khalatyan, N., Khanov, A., Kharchilava, A., Kharzheev, Y. N., Kiselevich, I., Kohli, J. M., Kopal, J., Kozelov, A. V., Kraus, J., Kumar, A., Kundr'at, V., Kupco, A., Kurvca, T., Kuzmin, V. A., Lami, S., Lammers, S., Latino, G., Lebrun, P., Lee, H. S., Lee, S. W., Lee, W. M., Le, X., Lellouch, J., Li, D., Li, H., Li, L., Li, Q. Z., Lim, J. K., Lincoln, D., Lindsey, C., Linhart, R., Linnemann, J., Lipaev, V. V., Lipton, R., Liu, H., Liu, Y., Lobodenko, A., Lokajicek, M., Lokaj'ivcek, M. V., de Sa, R. Lopes, Losurdo, L., Rodr'iguez, F. Lucas, Luna-Garcia, R., Lyon, A. L., Maciel, A. K. A., Macr'i, M., Madar, R., na-Villalba, R. Maga, Malawski, M., Malbouisson, H. B., Malik, S., Malyshev, V. L., Mansour, J., Mart'inez-Ortega, J., McCarthy, R., McGivern, C. L., Meijer, M. M., Melnitchouk, A., Menezes, D., Mercadante, P. G., Merkin, M., Meyer, A., Meyer, J., Miconi, F., Minafra, N., Minutoli, S., Molina, J., Mondal, N. K., Da Motta, H., Mulhearn, M., Mundim, L., Naaranoja, T., Nagy, E., Narain, M., Nayyar, R., Neal, H. A., Negret, J. P., Nemes, F., Neustroev, P., Nguyen, H. T., Niewiadomski, H., Nov'ak, T., Nunnemann, T., Oguri, V., Oliveri, E., Oljemark, F., Orduna, J., Oriunno, M., Osman, N., "Osterberg, K., Pal, A., Palazzi, P., Parashar, N., Parihar, V., Park, S. K., Partridge, R., Parua, N., Pasechnik, R., Passaro, V., Patwa, A., Penning, B., Perfilov, M., Peroutka, Z., Peters, Y., Petridis, K., Petrillo, G., P'etroff, P., Pleier, M. -A., Podstavkov, V. M., Popov, A. V., Da Silva, W. L. Prado, Prewitt, M., Price, D., Proch'azka, J., Prokopenko, N., Qian, J., Quadt, A., Quinn, B., Quinto, M., Raben, T. G., Radermacher, E., Rangel, M., Radicioni, E., Ratoff, P. N., Ravotti, F., Razumov, I., Ripp-Baudot, I., Rizatdinova, F., Robutti, E., Rodrigues, R. F., Rominsky, M., Ross, A., Royon, C., Rubinov, P., Ruchti, R., Ruggiero, G., Saarikko, H., Sajot, G., Samoylenko, V. D., S'anchez-Hern'andez, A., Sanders, M. P., Santoro, A., Santos, A. S., Savage, G., Savitskyi, M., Sawyer, L., Scanlon, T., Schamberger, R. D., Scheglov, Y., Schellman, H., Schott, M., Schwanenberger, C., Schwienhorst, R., Scribano, A., Sekaric, J., Severini, H., Shabalina, E., Shary, V., Shaw, S., Shchukin, A. A., Shkola, O., Simak, V., Siroky, J., Skubic, P., Slattery, P., Smajek, J., Snoeys, W., Snow, G. R., Snow, J., Snyder, S., S"oldner-Rembold, S., Sonnenschein, L., Soustruznik, K., Stark, J., Stefaniuk, N., Stefanovitch, R., Ster, A., Stoyanova, D. A., Strauss, M., Suter, L., Svoisky, P., Szanyi, I., Sziklai, J., Taylor, C., Tcherniaev, E., Titov, M., Tokmenin, V. V., Tsai, Y. -T., Tsybychev, D., Tuchming, B., Tully, C., Turini, N., Urban, O., Uvarov, L., Uvarov, S., Uzunyan, S., Vacek, V., Van Kooten, R., van Leeuwen, W. M., Varelas, N., Varnes, E. W., Vasilyev, I. A., Vavroch, O., Verkheev, A. Y., Vertogradov, L. S., Verzocchi, M., Vesterinen, M., Vilanova, D., Vokac, P., Wahl, H. D., Wang, C., Wang, M. H. L. S., Warchol, J., Watts, G., Wayne, M., Weichert, J., Welti, J., Welty-Rieger, L., Williams, J., Williams, M. R. J., Wilson, G. W., Wobisch, M., Wood, D. R., Wyatt, T. R., Xie, Y., Yamada, R., Yang, S., Yasuda, T., Yatsunenko, Y. A., Ye, W., Ye, Z., Yin, H., Yip, K., Youn, S. W., Yu, J. M., Zennamo, J., Zhao, T. G., Zhou, B., Zhu, J., Zich, J., Zielinski, K., Zielinski, M., Zieminska, D., and Zivkovic, L.

Subjects
High Energy Physics - Experiment
Abstract

We describe an analysis comparing the $p\bar{p}$ elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in $pp$ collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model-independent approach. The TOTEM cross sections extrapolated to a center-of-mass energy of $\sqrt{s} =$ 1.96 TeV are compared with the D0 measurement in the region of the diffractive minimum and the second maximum of the $pp$ cross section. The two data sets disagree at the 3.4$\sigma$ level and thus provide evidence for the $t$-channel exchange of a colorless, $C$-odd gluonic compound, also known as the odderon. We combine these results with a TOTEM analysis of the same $C$-odd exchange based on the total cross section and the ratio of the real to imaginary parts of the forward elastic scattering amplitude in $pp$ scattering. The combined significance of these results is larger than 5$\sigma$ and is interpreted as the first observation of the exchange of a colorless, $C$-odd gluonic compound., Comment: D0 and TOTEM Collaborations

Published
2020
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119. Orbital and Spin Character of Doped Carriers in Infinite-Layer Nickelates

Author

Rossi, M., Lu, H., Nag, A., Li, D., Osada, M., Lee, K., Wang, B. Y., Agrestini, S., Garcia-Fernandez, M., Chuang, Y. -D., Shen, Z. X., Hwang, H. Y., Moritz, B., Zhou, Ke-Jin, Devereaux, T. P., and Lee, W. S.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

The recent discovery of superconductivity in Nd$_{1-x}$Sr$_{x}$NiO$_2$ has drawn significant attention in the field. A key open question regards the evolution of the electronic structure with respect to hole doping. Here, we exploit x-ray absorption spectroscopy (XAS) and resonant inelastic x-ray scattering (RIXS) to probe the doping dependent electronic structure of the NiO$_2$ planes. Upon doping, a higher energy feature in Ni $L_3$ edge XAS develops in addition to the main absorption peak. By comparing our data to atomic multiplet calculations including $D_{4h}$ crystal field, the doping induced feature is consistent with a $d^8$ spin singlet state, in which doped holes reside in the $d_{x^2-y^2}$ orbitals, similar to doped single band Hubbard models. This is further supported by orbital excitations observed in RIXS spectra, which soften upon doping, corroborating with Fermi level shift associated with increasing holes in the $d_{x^2-y^2}$ orbital., Comment: 6 pages, 4 figures. Supplemental material included

Published
2020
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120. Continuing the Role of the Citizen Scientist: Larval & Pupal Collections for National Mosquito Distribution Surveys

Author

Tsecouras, Julie, Walton, William, Schimerlik, Roselyn, and Cohnstaedt, Lee W.

Abstract

New introductions to invasive mosquitoes, Aedes aegypti and Aedes albopictus, increase the risk for vector-borne diseases such as dengue, chikungunya, and Zika in the United States. Tracking these new introductions is more important than ever. This lesson plan focuses on the collection of mosquito larvae and pupae before the onset of summer with a focus on insect development. Students will observe the immature mosquitoes grow and metamorphose into adults. Novel aspects include collecting larvae and pupae around the home/school, observing the mosquito life cycle by safely rearing them from immature stages (larvae and pupae) to adults, and learning important background information on mosquito biology and pathogens that mosquitoes can transmit. The lesson describes new tools to use with the Invasive Mosquito Project, an international citizen science-based mosquito surveillance program exploring mosquitoes and the pathogens they may transmit to interested community members (including students and teachers) and their companion animals. This project is a stand-alone or follow-up lesson plan to the mosquito egg collection lesson used prior to the onset of winter (see Cohnstaedt et al., 2016). Students are able to participate in a hands-on tutorial to build a sealed emergence chamber to safely raise mosquitoes. Long-term data sets can also be used by teachers and students for further classroom discussions on the risks of mosquito- borne illnesses nationwide. This lesson further focuses on how individuals must play an active role in protecting their communities and pets from illness and increasing awareness of the dangerous pathogens mosquitoes can transmit and the importance of mosquito management. Materials from this lesson plan (available at http://www. citizenscience.us) can be adapted for each classroom but are best suited for middle school to high school classes, as well as Advanced Placement classes.

Published
2022
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124. Genome screening, reporting, and genetic counseling for healthy populations

Author

Casalino, Selina, Frangione, Erika, Chung, Monica, MacDonald, Georgia, Chowdhary, Sunakshi, Mighton, Chloe, Faghfoury, Hanna, Bombard, Yvonne, Strug, Lisa, Pugh, Trevor J., Simpson, Jared, Arnoldo, Saranya, Aujla, Navneet, Bearss, Erin, Binnie, Alexandra, Borgundvaag, Bjug, Chertkow, Howard, Clausen, Marc, Dagher, Marc, Devine, Luke, Di Iorio, David, Friedman, Steven Marc, Fung, Chun Yiu Jordan, Gingras, Anne-Claude, Goneau, Lee W., Kaushik, Deepanjali, Khan, Zeeshan, Lapadula, Elisa, Lu, Tiffany, Mazzulli, Tony, McGeer, Allison, McLeod, Shelley L., Morgan, Gregory, Richardson, David, Singh, Harpreet, Stern, Seth, Taher, Ahmed, Wong, Iris, Zarei, Natasha, Greenfeld, Elena, Hao, Limin, Lebo, Matthew, Lane, William, Noor, Abdul, Taher, Jennifer, and Lerner-Ellis, Jordan

Published
2023
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127. Three dimensional collective charge excitations in electron-doped cuprate superconductors

Author

Hepting, M., Chaix, L., Huang, E. W., Fumagalli, R., Peng, Y. Y., Moritz, B., Kummer, K., Brookes, N. B., Lee, W. C., Hashimoto, M., Sarkar, T., He, J. F., Rotundu, C. R., Lee, Y. S., Greene, R. L., Braicovich, L., Ghiringhelli, G., Shen, Z. X., Devereaux, T. P., and Lee, W. S.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

High temperature cuprate superconductors consist of stacked CuO2 planes, with primarily two dimensional electronic band structures and magnetic excitations, while superconducting coherence is three dimensional. This dichotomy highlights the importance of out-of-plane charge dynamics, believed to be incoherent in the normal state, yet lacking a comprehensive characterization in energy-momentum space. Here, we use resonant inelastic x-ray scattering (RIXS) with polarization analysis to uncover the pure charge character of a recently discovered collective mode in electron-doped cuprates. This mode disperses along both the in- and, importantly, out-of-plane directions, revealing its three dimensional nature. The periodicity of the out-of-plane dispersion corresponds to the CuO2 plane distance rather than the crystallographic c-axis lattice constant, suggesting that the interplane Coulomb interaction drives the coherent out-of-plane charge dynamics. The observed properties are hallmarks of the long-sought acoustic plasmon, predicted for layered systems and argued to play a substantial role in mediating high temperature superconductivity., Comment: This is the version of first submission. The revised manuscript according to peer reviews is now accepted by Nature and will be published online on 31st Oct., 2018

Published
2018
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128. Femtotesla direct magnetic gradiometer using a single multipass cell

Author

Lucivero, V. G., Lee, W., Dural, N., and Romalis, M. V.

Subjects
Physics - Atomic Physics, Physics - Instrumentation and Detectors, Quantum Physics
Abstract

We describe a direct gradiometer using optical pumping with opposite circular polarization in two $^{87}$Rb atomic ensembles within a single multipass cell. A far-detuned probe laser undergoes a near-zero paramagnetic Faraday rotation due to the intrinsic subtraction of two contributions exceeding 3.5 rad from the highly-polarized ensembles. We develop analysis methods for the direct gradiometer signal and measure a gradiometer sensitivity of $10.1$ fT/cm$\sqrt{\mathrm{Hz}}$. We also demonstrate that our multipass design, in addition to increasing the optical depth, provides a fundamental advantage due to the significantly reduced effect of atomic diffusion on the spin noise time-correlation, in excellent agreement with theoretical estimate., Comment: 5 pages, 4 figures

Published
2020
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129. A survey of active galaxies at TeV photon energies with the HAWC gamma-ray observatory

Author

Albert, A., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., Dingus, B. L., DuVernois, M. A., Durocher, M., Díaz-Vélez, J. C., Engel, K., Espinoza, C., Fan, K. L., Alonso, M. Fernández, Fleischhack, H., Fraija, N., Galván-Gámez, A., García, D., García-González, J. A., Garfias, F., González, M. M., Goodman, J. A., Harding, J. P., Hernández, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kieda, D., Lara, A., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Martínez, O., Martinez-Castellanos, I., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Peisker, A., Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Schoorlemmer, H., Smith, A. J., Springer, R. W., Tollefson, K., Torres, I., Torres-Escobedo, R., Ureña-Mena, F., Villaseñor, L., Weisgarber, T., Willox, E., Zepeda, A., Zhou, H., and de León, C.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The High Altitude Water Cherenkov Gamma-Ray Observatory (HAWC) continuously detects TeV photons and particles within its large field-of-view, accumulating every day a deeper exposure of two thirds of the sky. We analyzed 1523~days of HAWC live data acquired over four and a half years, in a follow-up analysis of {138} nearby ($z<0.3$) active galactic nuclei from the {\em Fermi} 3FHL catalog culminating within $40^\circ$ of the zenith at Sierra Negra, the HAWC site. This search for persistent TeV emission used a maximum-likelihood analysis assuming intrinsic power-law spectra attenuated by pair production of gamma-ray photons with the extragalactic background light. HAWC clearly detects persistent emission from Mkn~421 and Mkn~501, the two brightest blazars in the TeV sky, at 65$\sigma$ and 17$\sigma$ level, respectively. {Weaker evidence for long-term emission is found for three other known very-high energy emitters:} the radiogalaxy M87 and the BL Lac objects VER~J0521+211 and 1ES~1215+303, the later two at $z\sim 0.1$. We find evidence for collective emission from the set of 30 previously reported very high-energy sources that excludes Mkn~421 and Mkn~501 with a random probability $\sim 10^{-5}$. Upper limits are presented for the sample under the power-law assumption and in the predefined (0.5-2.0), (2.0-8.0) and (8.0-32.0) TeV energy intervals., Comment: The HAWC survey of Fermi 3FHL AGNs: 30 pages, 13 figures. Submitted to the Astrophysical Journal

Published
2020
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130. Semimetal to semiconductor transition in $\text{Bi}/\text{TiO}_{2}$ core/shell nanowires

Author

Kockert, M., Mitdank, R., Moon, H., Kim, J., Mogilatenko, A., Moosavi, S. H., Kroener, M., Woias, P., Lee, W., and Fischer, S. F.

Subjects
Physics - Applied Physics
Abstract

We demonstrate the full thermoelectric and structural characterization of individual bismuth-based (Bi-based) core/shell nanowires. The influence of strain on the temperature dependence of the electrical conductivity, the absolute Seebeck coefficient and the thermal conductivity of bismuth/titanium dioxide ($\text{Bi}/\text{TiO}_{2}$) nanowires with different diameters is investigated and compared to bismuth (Bi) and bismuth/tellurium (Bi/Te) nanowires and bismuth bulk. Scattering at surfaces, crystal defects and interfaces between the core and the shell reduces the electrical conductivity to less than $5\,\%$ and the thermal conductivity to less than $25\,\%$ to $50\,\%$ of the bulk value at room temperature. On behalf of a compressive strain, $\text{Bi}/\text{TiO}_{2}$ core/shell nanowires show a decreasing electrical conductivity with decreasing temperature opposed to that of Bi and Bi/Te nanowires. We find that the compressive strain induced by the $\text{TiO}_{2}$ shell can lead to a band opening of bismuth increasing the absolute Seebeck coefficient by $10\,\%$ to $30\,\%$ compared to bulk at room temperature. In the semiconducting state, the activation energy is determined to $\left|41.3\pm0.2\right|\,\text{meV}$. We show that if the strain exceeds the elastic limit the semimetallic state is recovered due to the lattice relaxation.

Published
2020

131. 3HWC: The Third HAWC Catalog of Very-High-Energy Gamma-ray Sources

Author

Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., de León, S. Coutiño, De la Fuente, E., Hernandez, R. Diaz, Diaz-Cruz, L., Dingus, B. L., DuVernois, M. A., Durocher, M., Díaz-Vélez, J. C., Ellsworth, R. W., Engel, K., Espinoza, C., Fan, K. L., Fang, K., Alonso, M. Fernández, Fleischhack, H., Fraija, N., Galván-Gámez, A., Garcia, D., García-González, J. A., Garfias, F., Giacinti, G., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hinton, J., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kieda, D., Lara, A., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., López-Coto, R., Malone, K., Marandon, V., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Olivera-Nieto, L., Omodei, N., Peisker, A., Araujo, Y. Pérez, Pérez-Pérez, E. G., Ren, Z., Rho, C. D., Rivière, C., Rosa-González, D., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Schoorlemmer, H., Serna, F., Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Tabachnick, E., Tollefson, K., Torres, I., Torres-Escobedo, R., Ukwatta, T. N., Ureña-Mena, F., Weisgarber, T., Werner, F., Willox, E., Zepeda, A., Zhou, H., de León, C., and Álvarez, J. D.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We present a new catalog of TeV gamma-ray sources using 1523 days of data from the High Altitude Water Cherenkov (HAWC) observatory. The catalog represents the most sensitive survey of the Northern gamma-ray sky at energies above several TeV, with three times the exposure compared to the previous HAWC catalog, 2HWC. We report 65 sources detected at $\geq$ 5 sigma significance, along with the positions and spectral fits for each source. The catalog contains eight sources that have no counterpart in the 2HWC catalog, but are within $1^\circ$ of previously detected TeV emitters, and twenty sources that are more than $1^\circ$ away from any previously detected TeV source. Of these twenty new sources, fourteen have a potential counterpart in the fourth \textit{Fermi} Large Area Telescope catalog of gamma-ray sources. We also explore potential associations of 3HWC sources with pulsars in the ATNF pulsar catalog and supernova remnants in the Galactic supernova remnant catalog., Comment: 20 pages, 11 figures. Matches the version published in The Astrophysical Journal. See accompanying data release at https://data.hawc-observatory.org/datasets/3hwc-survey/index.php

Published
2020
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132. A search for optical and near-infrared counterparts of the compact binary merger GW190814

Author

Thakur, A. L., Dichiara, S., Troja, E., Chase, E. A., Sanchez-Ramirez, R., Piro, L., Fryer, C. L., Butler, N. R., Watson, A. M., Wollaeger, R. T., Ambrosi, E., González, J. Becerra, Becerra, R. L., Bruni, G., Cenko, S. B., Cusumano, G., D'Aì, Antonino, Durbak, J., Fontes, C. J., Gatkine, P., Hungerford, A. L., Korobkin, O., Kutyrev, A. S., Lee, W. H., Lotti, S., Minervini, G., Novara, G., La Parola, V., Pereyra, M., Ricci, R., Tiengo, A., and Veilleux, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on our observing campaign of the compact binary merger GW190814, detected by the Advanced LIGO and Advanced Virgo detectors on August 14th, 2019. This signal has the best localisation of any observed gravitational wave (GW) source, with a 90% probability area of 18.5 deg$^2$, and an estimated distance of ~ 240 Mpc. We obtained wide-field observations with the Deca-Degree Optical Transient Imager (DDOTI) covering 88% of the probability area down to a limiting magnitude of $w$ = 19.9 AB. Nearby galaxies within the high probability region were targeted with the Lowell Discovery Telescope (LDT), whereas promising candidate counterparts were characterized through multi-colour photometry with the Reionization and Transients InfraRed (RATIR) and spectroscopy with the Gran Telescopio de Canarias (GTC). We use our optical and near-infrared limits in conjunction with the upper limits obtained by the community to constrain the possible electromagnetic counterparts associated with the merger. A gamma-ray burst seen along its jet's axis is disfavoured by the multi-wavelength dataset, whereas the presence of a burst seen at larger viewing angles is not well constrained. Although our observations are not sensitive to a kilonova similar to AT2017gfo, we can rule out high-mass (> 0.1 M$_{\odot}$) fast-moving (mean velocity >= 0.3c) wind ejecta for a possible kilonova associated with this merger., Comment: 17 pages, 11 figures, 5 tables; updated acknowledgement section. Accepted for publication in MNRAS (10 September 2020)

Published
2020
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133. Spectroscopic Evidence for Charge Order Melting via Quantum Fluctuations in a Cuprate

Author

Lee, W. S., Zhou, K. J., Hepting, M., Li, J., Nag, A., Walters, A. C., Garcia-Fernandez, M., Robarts, H., Hashimoto, M., Lu, H., Nosarzewski, B., Song, D., Eisaki, H., Shen, Z. X., Moritz, B., Zaanen, J., and Devereaux, T. P.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

Copper-oxide high TC superconductors possess a number of exotic orders co-existing with or proximal to superconductivity, whose quantum fluctuations may account for the unusual behaviors of the normal state, even affecting superconductivity. Yet, spectroscopic evidence about such quantum fluctuations remains elusive. Here, we reveal spectroscopic fingerprints for such fluctuations associated with a charge order (CO) in nearly optimally-doped Bi2Sr2CaCu2O8+d, using resonant inelastic x-ray scattering (RIXS). In the superconducting state, while the quasi-elastic CO signal decreases with temperature, the interplay between CO fluctuations and bond-stretching phonons in the form of a Fano-like interference paradoxically increases, incompatible with expectations for competing orders. Invoking general principles, we argue that this behavior reflects the properties of a dissipative system near an order-disorder quantum critical point, where the dissipation varies with the opening of the pseudogap and superconducting gap at low temperatures, leading to the proliferation of quantum critical fluctuations which melt CO., Comment: 24 pages, Supplementary Information included. This is the original submitted manuscript

Published
2020
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134. HAWC J2227+610 and its association with G106.3+2.7, a new potential Galactic PeVatron

Author

Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., Diaz-Cruz, L., Dingus, B. L., DuVernois, M. A., Díaz-Vélez, J. C., Ellsworth, R. W., Engel, K., Espinoza, C., Fan, K. L., Fang, K., Alonso, M. Fernández, Fleischhack, H., Fraija, N., Galván-Gámez, A., Garcia, D., García-González, J. A., Garfias, F., Giacinti, G., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hinton, J., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., Malone, K., Marinelli, S. S., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Omodei, N., Peisker, A., Araujo, Y. Pérez, Pérez-Pérez, E. G., Rho, C. D., Rosa-González, D., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Schoorlemmer, H., Franco, J. Serna, Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Tabachnick, E., Tanner, M., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Ureña-Mena, F., Villaseñor, L., Weisgarber, T., Zepeda, A., Zhou, H., de León, C., and Álvarez, J. D.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present the detection of VHE gamma-ray emission above 100 TeV from HAWC J2227+610 with the HAWC observatory. Combining our observations with previously published results by VERITAS, we interpret the gamma-ray emission from HAWC J2227+610 as emission from protons with a lower limit in their cutoff energy of 800 TeV. The most likely source of the protons is the associated supernova remnant G106.3+2.7, making it a good candidate for a Galactic PeVatron. However, a purely leptonic origin of the observed emission cannot be excluded at this time., Comment: Accepted for publication by ApJL

Published
2020
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135. Constraints on the Emission of Gamma Rays from M31 with HAWC

Author

HAWC Collaboration, Albert, A., Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Dichiara, S., Dingus, B. L., DuVernois, M. A., Engel, K., Espinoza, C., Fleischhack, H., Fraija, N., Galván-Gámez, A., García-Aguilar, D., García-González, J. A., Garfias, F., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Jardin-Blicq, A., Joshi, V., Kieda, D., Lee, W. H., Vargas, H. León, Longinotti, A. L., Luis-Raya, G., Malone, K., Marinelli, S. S., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Noriega-Papaqui, R., Peisker, A., Pérez-Pérez, E. G., Ren, Z., Rho, C. D., Rosa-González, D., Rosenberg, M., Rubenzahl, R., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Tabachnick, E., Tibolla, O., Tollefson, K., Torres, I., Villaseñor, L., Wood, J., Yapici, T., Zepeda, A., and Zhou, H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Cosmic rays, along with stellar radiation and magnetic fields, are known to make up a significant fraction of the energy density of galaxies such as the Milky Way. When cosmic rays interact in the interstellar medium, they produce gamma-ray emission which provides an important indication of how the cosmic rays propagate. Gamma rays from the Andromeda Galaxy (M31), located 785 kpc away, provide a unique opportunity to study cosmic-ray acceleration and diffusion in a galaxy with a structure and evolution very similar to the Milky Way. Using 33 months of data from the High Altitude Water Cherenkov Observatory, we search for TeV gamma rays from the galactic plane of M31. We also investigate past and present evidence of galactic activity in M31 by searching for Fermi Bubble-like structures above and below the galactic nucleus. No significant gamma-ray emission is observed, so we use the null result to compute upper limits on the energy density of cosmic rays $>10$ TeV in M31. The computed upper limits are approximately ten times higher than expected from the extrapolation of the Fermi LAT results., Comment: Accepted for publication in ApJ

Published
2020
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136. Portable magnetometry for detection of biomagnetism in ambient environments

Author

Limes, M. E., Foley, E. L., Kornack, T. W., Caliga, S., McBride, S., Braun, A., Lee, W., Lucivero, V. G., and Romalis, M. V.

Subjects
Physics - Medical Physics, Physics - Atomic Physics, Physics - Instrumentation and Detectors
Abstract

We present a method of optical magnetometry with parts-per-billion resolution that is able to detect biomagnetic signals generated from the human brain and heart in Earth's ambient environment. Our magnetically silent sensors measure the total magnetic field by detecting the free-precession frequency of highly spin-polarized alkali metal vapor. A first-order gradiometer is formed from two magnetometers that are separated by a 3 cm baseline. Our gradiometer operates from a laptop consuming 5 W over a USB port, enabled by state-of-the-art micro-fabricated alkali vapor cells, advanced thermal insulation, custom electronics, and laser packages within the sensor head. The gradiometer obtains a sensitivity of 16 fT/cm/Hz$^{1/2}$ outdoors, which we use to detect neuronal electrical currents and magnetic cardiography signals. Recording of neuronal magnetic fields is one of a few available methods for non-invasive functional brain imaging that usually requires extensive magnetic shielding and other infractructure. This work demonstrates the possibility of a dense array of portable biomagnetic sensors that are deployable in a variety of natural environments.

Published
2020
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137. Risk factors for extended-spectrum beta-lactamase (ESBL)-producing E. coli carriage among children in a food animal-producing region of Ecuador: A repeated measures observational study.

Author

Heather K Amato, Fernanda Loayza, Liseth Salinas, Diana Paredes, Daniela Garcia, Soledad Sarzosa, Carlos Saraiva-Garcia, Timothy J Johnson, Amy J Pickering, Lee W Riley, Gabriel Trueba, and Jay P Graham

Subjects
Medicine
Abstract

BackgroundThe spread of antibiotic-resistant bacteria may be driven by human-animal-environment interactions, especially in regions with limited restrictions on antibiotic use, widespread food animal production, and free-roaming domestic animals. In this study, we aimed to identify risk factors related to commercial food animal production, small-scale or "backyard" food animal production, domestic animal ownership, and practices related to animal handling, waste disposal, and antibiotic use in Ecuadorian communities.Methods and findingsWe conducted a repeated measures study from 2018 to 2021 in 7 semirural parishes of Quito, Ecuador to identify determinants of third-generation cephalosporin-resistant E. coli (3GCR-EC) and extended-spectrum beta-lactamase E. coli (ESBL-EC) in children. We collected 1,699 fecal samples from 600 children and 1,871 domestic animal fecal samples from 376 of the same households at up to 5 time points per household over the 3-year study period. We used multivariable log-binomial regression models to estimate relative risks (RR) of 3GCR-EC and ESBL-EC carriage, adjusting for child sex and age, caregiver education, household wealth, and recent child antibiotic use. Risk factors for 3GCR-EC included living within 5 km of more than 5 commercial food animal operations (RR: 1.26; 95% confidence interval (CI): 1.10, 1.45; p-value: 0.001), household pig ownership (RR: 1.23; 95% CI: 1.02, 1.48; p-value: 0.030) and child pet contact (RR: 1.23; 95% CI: 1.09, 1.39; p-value: 0.001). Risk factors for ESBL-EC were dog ownership (RR: 1.35; 95% CI: 1.00, 1.83; p-value: 0.053), child pet contact (RR: 1.54; 95% CI: 1.10, 2.16; p-value: 0.012), and placing animal feces on household land/crops (RR: 1.63; 95% CI: 1.09, 2.46; p-value: 0.019). The primary limitations of this study are the use of proxy and self-reported exposure measures and the use of a single beta-lactamase drug (ceftazidime with clavulanic acid) in combination disk diffusion tests for ESBL confirmation, potentially underestimating phenotypic ESBL production among cephalosporin-resistant E. coli isolates. To improve ESBL determination, it is recommended to use 2 combination disk diffusion tests (ceftazidime with clavulanic acid and cefotaxime with clavulanic acid) for ESBL confirmatory testing. Future studies should also characterize transmission pathways by assessing antibiotic resistance in commercial food animals and environmental reservoirs.ConclusionsIn this study, we observed an increase in enteric colonization of antibiotic-resistant bacteria among children with exposures to domestic animals and their waste in the household environment and children living in areas with a higher density of commercial food animal production operations.

Published
2023
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139. Preserving orbital order in a layered manganite by ultrafast hybridized band excitation

Author

Shen, L., Mack, S., Dakovski, G., Coslovich, G., Krupin, O., Hoffmann, M., Huang, S-W., Chuang, Y-D., Johnson, J. A., Lieu, S., Zohar, S., Ford, C., Kozina, M., Schlotter, W., Minitti, M. P., Fujioka, J., Moore, R., Lee, W-S., Hussain, Z., Tokura, Y., Littlewood, P., and Turner, J. J.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

In the mixed-valence manganites, a near-infrared laser typically melts the orbital and spin order simultaneously, corresponding to the photoinduced $d^{1}d^{0}$ $\xrightarrow{}$ $d^{0}d^{1}$ excitations in the Mott-Hubbard bands of manganese. Here, we use ultrafast methods -- both femtosecond resonant x-ray diffraction and optical reflectivity -- to demonstrate that the orbital response in the layered manganite Nd$_{1-x}$Sr$_{1+x}$MnO$_{4}$ ($\it{x}$ = 2/3) does not follow this scheme. At the photoexcitation saturation fluence, the orbital order is only diminished by a few percent in the transient state. Instead of the typical $d^{1}d^{0}$ $\xrightarrow{}$ $d^{0}d^{1}$ transition, a near-infrared pump in this compound promotes a fundamentally distinct mechanism of charge transfer, the $d^{0}$ $ \xrightarrow{}$ $d^{1}L$, where $\it{L}$ denotes a hole in the oxygen band. This novel finding may pave a new avenue for selectively manipulating specific types of order in complex materials of this class.

Published
2019
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140. A new experiment to test parity symmetry in cold chiral molecules using vibrational spectroscopy

Author

Cournol, A, Manceau, M., Pierens, M., Lecordier, L, Tran, D, Santagata, R., Argence, B., Goncharov, A, Lopez, O., Abgrall, M., Coq, Y. Le, Targat, R. Le, Martinez, H Alvarez, Lee, W, Xu, D, Pottie, P-E, Hendricks, R, Wall, T, Bieniewska, J, Sauer, B, Tarbutt, M., Amy-Klein, A., Tokunaga, S., and Darquié, B.

Subjects
Physics - Atomic Physics, Physics - Chemical Physics
Abstract

We present a brief review of our progress towards measuring parity violation in heavy-metal chiral complexes using mid-infrared Ramsey interferometry. We discuss our progress addressing the main challenges, including the development of buffer-gas sources of slow, cold polyatomic molecules, and the frequency-stabilisation of quantum cascade lasers calibrated using primary frequency standards. We report investigations on achiral test species of which promising chiral derivatives have been synthesized.

Published
2019
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141. Constraints on Lorentz invariance violation from HAWC observations of gamma rays above 100 TeV

Author

HAWC Collaboration, Albert, A., Alfaro, R., Alvarez, C., Camacho, J. R. Angeles, Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., de León, S. Coutiño, De la Fuente, E., de León, C., Dingus, B. L., DuVernois, M. A., Díaz-Vélez, J. C., Ellsworth, R. W., Engel, K., Espinoza, C., Fleischhack, H., Fraija, N., Galván-Gámez, A., Garcia, D., García-González, J. A., Garfias, F., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Joshi, V., Lara, A., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., López-Coto, R., Malone, K., Marinelli, S. S., Martinez-Castellanos, I., Martínez-Castro, J., Martínez-Huerta, H., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Omodei, N., Peisker, A., Pérez-Pérez, E. G., Rho, C. D., Rivière, C., Rosa-González, D., Rosenberg, M., Ruiz-Velasco, E., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Schoorlemmer, H., Sinnis, G., Smith, A. J., Springer, R. W., Surajbali, P., Tabachnick, E., Tanner, M., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Weisgarber, T., Yodh, G., Zepeda, A., and Zhou, H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Due to the high energies and long distances to the sources, astrophysical observations provide a unique opportunity to test possible signatures of Lorentz invariance violation (LIV). Superluminal LIV enables the decay of photons at high energy. The High Altitude Water Cherenkov (HAWC) Observatory is among the most sensitive gamma-ray instruments currently operating above 10 TeV. HAWC finds evidence of 100 TeV photon emission from at least four astrophysical sources. These observations exclude, for the strongest of the limits set, the LIV energy scale to $2.2\times10^{31}$ eV, over 1800 times the Planck energy and an improvement of 1 to 2 orders of magnitude over previous limits., Comment: Accepted for publication in Physical Review Letters

Published
2019
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142. Constraining the Local Burst Rate Density of Primordial Black Holes with HAWC

Author

Albert, A., Alfaro, R., Alvarez, C., Arteaga-Velázquez, J. C., Arunbabu, K. P., Rojas, D. Avila, Solares, H. A. Ayala, Baghmanyan, V., Belmont-Moreno, E., BenZvi, S. Y., Brisbois, C., Caballero-Mora, K. S., Capistrán, T., Carramiñana, A., Casanova, S., Cotti, U., Cotzomi, J., De la Fuente, E., de León, C., Dingus, B. L., DuVernois, M. A., Díaz-Vélez, J. C., Ellsworth, R. W., Engel, K. L., Espinoza, C., Fleischhack, H., Fraija, N., Galván-Gámez, A., García-González, J. A., Garfias, F., González, M. M., Goodman, J. A., Harding, J. P., Hernandez, S., Hona, B., Huang, D., Hueyotl-Zahuantitla, F., Hüntemeyer, P., Iriarte, A., Joshi, V., Lara, A., Lee, W. H., Vargas, H. León, Linnemann, J. T., Longinotti, A. L., Luis-Raya, G., Lundeen, J., López-Coto, R., Malone, K., Marinelli, S. S., Martinez, O., Martinez-Castellanos, I., Martínez-Castro, J., Martínez-Huerta, H., Matthews, J. A., Miranda-Romagnoli, P., Morales-Soto, J. A., Moreno, E., Mostafá, M., Nayerhoda, A., Nellen, L., Newbold, M., Nisa, M. U., Noriega-Papaqui, R., Peisker, A., Pérez-Pérez, E. G., Rho, C. D., Rivière, C., Rosa-González, D., Rosenberg, M., Salazar, H., Greus, F. Salesa, Sandoval, A., Schneider, M., Sinnis, G., Smith, A. J., Springer, R. W., Tabachnick, E., Tanner, M., Tibolla, O., Tollefson, K., Torres, I., Torres-Escobedo, R., Weisgarber, T., Wood, J., Zepeda, A., and Zhou, H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

Primordial Black Holes (PBHs) may have been created by density fluctuations in the early Universe and could be as massive as $> 10^9$ solar masses or as small as the Planck mass. It has been postulated that a black hole has a temperature inversely-proportional to its mass and will thermally emit all species of fundamental particles via Hawking Radiation. PBHs with initial masses of $\sim 5 \times 10^{14}$ g (approximately one gigaton) should be expiring today with bursts of high-energy gamma radiation in the GeV--TeV energy range. The High Altitude Water Cherenkov (HAWC) Observatory is sensitive to gamma rays with energies of $\sim$300 GeV to past 100 TeV, which corresponds to the high end of the PBH burst spectrum. With its large instantaneous field-of-view of $\sim 2$ sr and a duty cycle over 95%, the HAWC Observatory is well suited to perform an all-sky search for PBH bursts. We conducted a search using 959 days of HAWC data and exclude the local PBH burst rate density above $3400~\mathrm{pc^{-3}~yr^{-1}}$ at 99% confidence, the strongest limit on the local PBH burst rate density from any existing electromagnetic measurement., Comment: Corresponding authors: K.L. Engel & A. Peisker. 13 pages, 5 figures

Published
2019
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144. The Pacific water flow branches in the eastern Chukchi Sea

Author

Pickart, Robert S., Lin, Peigen, Bahr, Frank, McRaven, Leah T., Huang, Jie, Pacini, Astrid, Arrigo, Kevin R., Ashjian, Carin J., Berchok, Catherine, Baumgartner, Mark F., Cho, Kyoung-Ho, Cooper, Lee W., Danielson, Seth L., Dasher, Douglas, Fuiwara, Amane, Gann, Jeanette, Grebmeier, Jacqueline M., He, Jianfeng, Hirawake, Toru, Itoh, Motoyo, Juranek, Lauren, Kikuchi, Takashi, Moore, G.W.K., Napp, Jeff, John Nelson, R., Nishino, Shigeto, Statscewich, Hank, Stabeno, Phyllis, Stafford, Kathleen M., Ueno, Hiromichi, Vagle, Svein, Weingartner, Thomas J., Williams, Bill, and Zimmermann, Sarah

Published
2023
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150. Prostate Radiotherapy With Adjuvant Androgen Deprivation Therapy (ADT) Improves Metastasis-Free Survival Compared to Neoadjuvant ADT: An Individual Patient Meta-Analysis.

Author

Spratt, Daniel E, Malone, Shawn, Roy, Soumyajit, Grimes, Scott, Eapen, Libni, Morgan, Scott C, Malone, Julia, Craig, Julia, Dess, Robert T, Jackson, William C, Hartman, Holly E, Kishan, Amar U, Mehra, Rohit, Kaffenberger, Samuel, Morgan, Todd M, Reichert, Zachery R, Alumkal, Joshi J, Michalski, Jeff, Lee, W Robert, Pisansky, Thomas M, Feng, Felix Y, Shipley, William, Sandler, Howard M, Schipper, Mathew J, Roach, Mack, Sun, Yilun, and Lawton, Colleen AF

Subjects
Clinical Research, Aging, Urologic Diseases, Prostate Cancer, Cancer, Clinical Trials and Supportive Activities, Good Health and Well Being, Androgen Antagonists, Clinical Trials, Phase III as Topic, Humans, Male, Neoadjuvant Therapy, Neoplasm Metastasis, Prostatic Neoplasms, Randomized Controlled Trials as Topic, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeThere remains a lack of clarity regarding the influence of sequencing of androgen deprivation therapy (ADT) and radiotherapy (RT) on outcomes in prostate cancer (PCa). Herein, we evaluate the optimal sequencing of ADT with prostate-directed RT in localized PCa.MethodsMEDLINE (1966-2018), Embase (1982-2018), ClinicalTrials.gov, and conference proceedings (1990-2018) were searched to identify randomized trials evaluating the sequencing, but not duration, of ADT with RT. Two randomized phase III trials were identified, and individual patient data were obtained: Ottawa 0101 and NRG Oncology's Radiation Therapy Oncology Group 9413. Ottawa 0101 randomly assigned patients to neoadjuvant or concurrent versus concurrent or adjuvant short-term ADT. Radiation Therapy Oncology Group 9413, a 2 × 2 factorial trial, included a random assignment of neoadjuvant or concurrent versus adjuvant short-term ADT. The neoadjuvant or concurrent ADT arms of both trials were combined into the neoadjuvant group, and the arms receiving adjuvant ADT were combined into the adjuvant group. The primary end point of this meta-analysis was progression-free survival (PFS).ResultsThe median follow-up was 14.9 years. Overall, 1,065 patients were included (531 neoadjuvant and 534 adjuvant). PFS was significantly improved in the adjuvant group (15-year PFS, 29% v 36%, hazard ratio [HR], 1.25 [95% CI, 1.07 to 1.47], P = .01). Biochemical failure (subdistribution HR [sHR], 1.37 [95% CI, 1.12 to 1.68], P = .002), distant metastasis (sHR, 1.40 [95% CI, 1.00 to 1.95], P = .04), and metastasis-free survival (HR, 1.17 [95% CI, 1.00 to 1.37], P = .050) were all significantly improved in the adjuvant group. There were no differences in late grade ≥ 3 gastrointestinal (2% v 3%, P = .33) or genitourinary toxicity (5% v 5%, P = .76) between groups.ConclusionThe sequencing of ADT with prostate-directed RT has significant association with long-term PFS and MFS in localized PCa. Our findings favor use of an adjuvant over a neoadjuvant approach, without any increase in long-term toxicity.

Published
2021

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