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949 results on '"Lee, Eun Seong"'

116. Combined Antitumor Therapy Using In Situ Injectable Hydrogels Formulated with Albumin Nanoparticles Containing Indocyanine Green, Chlorin e6, and Perfluorocarbon in Hypoxic Tumors

Author

Lee, Woo Tak, primary, Yoon, Johyun, additional, Kim, Sung Soo, additional, Kim, Hanju, additional, Nguyen, Nguyen Thi, additional, Le, Xuan Thien, additional, Lee, Eun Seong, additional, Oh, Kyung Taek, additional, Choi, Han-Gon, additional, and Youn, Yu Seok, additional

Published
2022
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119. Enhancement of Photoresponse on Narrow-Bandgap Mott Insulator α-RuCl3 via Intercalation

Author

Jo, Min-kyung, primary, Heo, Hoseok, additional, Lee, Jung-Hoon, additional, Choi, Seungwook, additional, Kim, Ansoon, additional, Jeong, Han Beom, additional, Jeong, Hu Young, additional, Yuk, Jong Min, additional, Eom, Daejin, additional, Jahng, Junghoon, additional, Lee, Eun Seong, additional, Jung, In-young, additional, Cho, Seong Rae, additional, Kim, Jeongtae, additional, Cho, Seorin, additional, Kang, Kibum, additional, and Song, Seungwoo, additional

Published
2021
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141. Investigation of a four-wave mixing signal generated in fiber-delivered CARS microscopy

Author

Jun, Chang Su, Kim, Byoung Yoon, Park, Ju Hyun, Lee, Jae Yong, Lee, Eun Seong, and Yeom, Dong-Il

Subjects
Signal processing -- Research, Raman effect -- Research, Microscope and microscopy -- Research, Digital signal processor, Astronomy, Physics
Abstract

We studied the nonlinear signal generated in the fiber at an anti-Stokes wavelength during the delivery of the picosecond (ps) pump and Stokes beams in coherent anti-Stokes Raman scattering (CARS) microscopy. A small non-phase-matched four-wave mixing (FWM) signal was prevalently observed in the fiber at the power level where other nonlinear processes, including self-phase modulation and cross-phase modulation, were well suppressed. We analyzed the features of the FWM signal generation by varying the location of temporal overlap between two input pulses in the fiber to compare this to the CARS signal generated in the sample. Numerical modeling based on the nonlinear SchrSdinger equation was also conducted and clearly explains the results in the experiment. In addition, we experimentally verified the interferometric feature of this FWM signal with the CARS signal by employing a phase-shifting unit, which potentially suggests the use of the FWM signal as a local oscillator for the interferometric CARS system. OCIS codes: 170.3880, 180.3170, 190.4370.

Published
2010

143. Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors

Author

Peppas, Nicholas A., Duncan, Ruth, Wnek, Gary E., Hoffman, Allan S., Gao, Guang Hui, Kim, Sung Wan, Lee, Doo Sung, Hadjiargyrou, Michael, Touitou, Elka, Ainbinder, Denize, Mumper, Russell, Rolland, Alain, Niidome, Takuro, Labhasetwar, Vinod, Liu, Shi, Zhou, Guangyuan, Huang, Yubin, Xie, Zhigang, Jing, Xiabin, Csaba, Noemi, Alonso, Maria Jose, Ali, Omar, Mooney, David J., Lönn, Peter, Dowdy, Steven F., Feng, Si-Shen, Gao, Jinming, Lee, Eun Seong, Na, Kun, Bae, You Han, Zentner, Gaylen M., Kim, Hyesung, Yoo, Hyuk Sang, Nakayama, Masamichi, Okano, Teruo, Liao, Zi-Xian, Chuang, Er-Yuan, Hsiao, Chun-Wen, Sung, Hsing-Wen, Cabral, Horacio, Kataoka, Kazunori, Nair, Praful R., Discher, Dennis, and Mitragotri, Samir

Published
2014
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149. Development of AE147 Peptide-Conjugated Nanocarriers for Targeting uPAR-Overexpressing Cancer Cells

Author

Park,June Yong, Shin,Yuseon, Won,Woong Roeck, Lim,Chaemin, Kim,Jae Chang, Kang,Kioh, Husni,Patihul, Lee,Eun Seong, Youn,Yu Seok, Oh,Kyung Taek, Park,June Yong, Shin,Yuseon, Won,Woong Roeck, Lim,Chaemin, Kim,Jae Chang, Kang,Kioh, Husni,Patihul, Lee,Eun Seong, Youn,Yu Seok, and Oh,Kyung Taek

Abstract

June Yong Park,1,* Yuseon Shin,1,* Woong Roeck Won,1 Chaemin Lim,1,2 Jae Chang Kim,1 Kioh Kang,1 Patihul Husni,1 Eun Seong Lee,3 Yu Seok Youn,4 Kyung Taek Oh1,5 1Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, Dongjak-gu, Seoul, 06974, Republic of Korea; 2Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; 3Division of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, 14662, Republic of Korea; 4School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 16419, Republic of Korea; 5College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 06974, Republic of Korea*These authors contributed equally to this workCorrespondence: Kyung Taek OhCollege of Pharmacy, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul, 06974, Republic of KoreaTel +82-2-824-5617Email kyungoh@cau.ac.krPurpose: An AE147 peptide-conjugated nanocarrier based on PEGylated liposomes was developed in order to target the metastatic tumors overexpressing urokinase-type plasminogen activator receptor (uPAR), which cancer progression via uPA signaling. Therefore, the AE147 peptide-conjugated nanocarrier system may hold the potential for active targeting of metastatic tumors.Methods: The AE147 peptide, an antagonist of uPAR, was conjugated to the PEGylated liposomes for targeting metastatic tumors overexpressing uPAR. Docetaxel (DTX), an anticancer drug, was incorporated into the nanocarriers. The structure of the AE147-conjugated nanocarrier, its physicochemical properties, and in vivo biodistribution were evaluated.Results: The DTX-loaded nanocarrier showed a spherical structure, a high drug-loading capacity, and a high colloidal stability. Drug carrying AE147 conjugates were actively taken up by the uPAR-overexpressing MDA-MB-231 cancer cells. In vivo animal imaging confirmed

Published
2021

150. Cyclic RGD-conjugated Pluronic® blending system for active, targeted drug delivery

Author

Lim, Chaemin, Moon, Junseong, Sim, Taehoon, Hoang, Ngoc Ha, Won, Woong Roeck, Lee, Eun Seong, Youn, Yu Seok, Choi, Han-Gon, Oh, Kyungsoo, and Oh, Kyung Taek

Subjects
active targeting, Mice, Inbred BALB C, Cell Survival, Drug Compounding, Mice, Nude, Antineoplastic Agents, Poloxamer, Integrin alphaVbeta3, blending micellar system, nanomedicine, Peptides, Cyclic, cyclic RGD, Endocytosis, Pluronic L121/F127, Drug Delivery Systems, Cell Line, Tumor, docetaxel, Animals, Humans, Nanoparticles, Female, Micelles, Original Research
Abstract

Background Blending micellar systems of different types of polymers has been proposed as an efficient approach for tailor-made drug formulations. The lamellar structure of hydrophobic polymers may provide a high drug loading capacity, and hydrophilic polymers may provide good colloidal stability. Methods In this study, the anticancer model drug docetaxel was loaded onto a nanosized blending micellar system with two pluronics (L121/F127). To achieve increased antitumor activity, the cyclic arginine-glycine-aspartic acid tripeptide (cRGD) as an active tumor targeting ligand was conjugated to the blending system. Results The docetaxel-loaded Pluronic blending system exhibited a higher drug loading capacity than that of F127 and showed high colloidal stability with a spherical structure. cRGD conjugates demonstrated enhanced drug cellular uptake and anticancer activity against αvβ3 integrin-overexpressing U87MG cancer cells. In vivo animal imaging also revealed that the prepared cRGD-conjugated nanoparticles effectively accumulated at the targeted tumor site through an active and passive targeting strategy. Conclusion Accordingly, the prepared nanosized system shows potential as a tailor-made, active targeting, nanomedicinal platform for anticancer therapy. We believe that this novel nanoplatform will provide insights for advancement of tumor therapy.

Published
2018

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