283 results on '"Leduc, G."'
Search Results
102. (730): Effect of odors in the pain perception
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Leduc, G., Bourgault, P., Gagné, M., and Marchand, S.
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- 2007
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103. Spectrochemistry and spectromicroscopy Multiple-energy X-ray holography with atomic resolution
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Gog, T., Eisenhower, R. A., Menk, R. H., Tegze, M., and Leduc, G.
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- 1998
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104. Brain lateralization probed by water diffusion at the atomic to micrometric scale
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Natali, F., Dolce, C., Peters, J., Stelletta, C., Demé, B., Ollivier, J., Leduc, G., Cupane, A., Barbier, E.L., Institut Laue-Langevin (ILL), ILL, Universita degli Studi di Padova, European Synchroton Radiation Facility [Grenoble] (ESRF), Università degli studi di Palermo - University of Palermo, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), ANR-11-INBS-0006,FLI,France Life Imaging(2011), ANR-15-IDEX-0002,UGA,IDEX UGA(2015), Natali F., Dolce C., Peters J., Stelletta C., Deme B., Ollivier J., Leduc G., Cupane A., and Barbier E.L.
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[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,brain ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,lcsh:Medicine ,Facilitated Diffusion ,Article ,Cerebellum ,Scattering, Small Angle ,Animals ,lcsh:Science ,Dominance, Cerebral ,Cerebrum ,Myelin Sheath ,Quantitative Biology::Neurons and Cognition ,neutron scattering ,lcsh:R ,Water ,water diffusion ,Molecular biophysics ,Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin) ,neutron scattering, diffusion nuclear magnetic resonance, water dynamics ,Neutron Diffraction ,Diffusion Magnetic Resonance Imaging ,lcsh:Q ,Cattle ,Astrophysics::Earth and Planetary Astrophysics ,Biological physics - Abstract
International audience; Combined neutron scattering and diffusion nuclear magnetic resonance experiments have been used to reveal significant interregional asymmetries (lateralization) in bovine brain hemispheres in terms of myelin arrangement and water dynamics at micron to atomic scales. Thicker myelin sheaths were found in the left hemisphere using neutron diffraction. 4.7 T dMRI and quasi-elastic neutron experiments highlighted significant differences in the properties of water dynamics in the two hemispheres. The results were interpreted in terms of hemisphere-dependent cellular composition (number of neurons, cell distribution, etc.) as well as specificity of neurological functions (such as preferential networking).
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105. First in vivo results in intravenous coronary angiography at the ESRF beamline.
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Elleaume, H., Esteve, F., Bertrand, B., Charvet, A. M., Le Bas, J. F., Leduc, G., Suortl, P., Brochard, T., Fiedler, S., Renier, M., and Nemoz, C.
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- 1999
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106. Screening programs for hypertension *
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Genest, J., Kuchel, O., Leduc, G., Granger, P., Boucher, R., Rojo-Ortega, J. M., and Nowaczynski, W.
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Adult ,Hypertension, Renal ,Adolescent ,Blood Pressure ,Middle Aged ,Medical Practice ,Cardiovascular Diseases ,Pregnancy ,Hypertension ,Renin ,Humans ,Mass Screening ,Education, Medical, Continuing ,Female ,Health Facilities ,Health Education ,Antihypertensive Agents ,Aged - Abstract
MAJOR SCREENING PROGRAMS FOR HYPERTENSION ARE NECESSARY FOR THE FOLLOWING REASONS: (a) the 12 to 15% prevalence of hypertension in the North American population; (b) the high proportion of hypertensive patients who are inadequately treated or whose disease is not even recognized; (c) the fact that in too many medical centres hypertension is poorly investigated or considered an insignificant finding; (d) the demonstration by many groups, especially the Framingham study, of hypertension as the major factor in the occurrence of severe cardiovascular disease; and (e) the achievement of a marked decrease in severe cardiovascular complications following adequate treatment. But such screening programs are of little value if unaccompanied by a major educational effort directed not only to the public but also to the medical profession, and a parallel increase in the funding of biomedical research into the basic physiopathological mechanisms of hypertension.
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- 1974
107. Le Problème de l'aide aux pays sous-développés Institut supérieur de Commerce Saint-Ignace d'Anvers
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Leduc, G.
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- 1954
108. Electronic screens in children's bedrooms and adiposity, physical activity and sleep: Do the number and type of electronic devices matter?
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Chaput, J. -P, Leduc, G., Boyer, C., Bélanger, P., Allana LeBlanc, Borghese, M. M., and Tremblay, M. S.
109. The toxicity of various mining flotation reagents to rainbow trout (Salmo gairdneri)☆
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WEBB, M, primary, RUBER, H, additional, and LEDUC, G, additional
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- 1976
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110. The influence of season and exercise on the lethal toxicity of cyanide to rainbow trout (Salmo gairdneri)
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McGeachy, Sandi M., primary and Leduc, G�rard, additional
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- 1988
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111. Chronic cyanide poisoning of rainbow trout and its effects on growth, respiration, and liver histopathology
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Dixon, D. George, primary and Leduc, G�rard, additional
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- 1981
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112. Inhibition of spermatogenesis in rainbow trout during chronic cyanide poisoning
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Ruby, Sylvia M., primary, Dixon, D. George, additional, and Leduc, G�rard, additional
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- 1979
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113. Le scandale du développement
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Zarka, Claude, primary, Austruy, Jacques, additional, Leduc, G., additional, Lebret, L.-J., additional, and Caire, Guy, additional
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- 1966
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114. Une observation de polyarthrite sévère en rapport avec une infection par Yersinia enterocolitica
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Bregeon, par C., primary, Renier, J.C., additional, Fonty, P., additional, Leduc, G., additional, and Mollaret, H.H., additional
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- 1973
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115. Le transfert social, fondement du progrès économique?
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Courault, Bruno, primary, Auctores, Varii, additional, and Leduc, G., additional
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- 1971
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116. Peripheral Assimilation of Fructose in Man.
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Van Itallie, T. B., primary, Morgan, M. C., additional, Cathcart, R. T., additional, Leduc, G. G., additional, and Dotti, L. B., additional
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- 1953
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117. First in vivoresults in intravenous coronary angiography at the ESRF beamline
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Elleaume, H., Esteve, F., Bertrand, B., Charvet, A.M., Le Bas, J.F., Leduc, G., Suortl, P., Brochard, T., Fiedler, S., Renier, M., and Nemoz, C.
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- 1999
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118. Cycle-based TCP-friendly algorithm
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Ait-Hellal, O., primary, Yamamoto, L., additional, and Leduc, G., additional
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119. Mobility Predictions Influence on QoS in Wireless Networks: A Study on a Call Admission Algorithm
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Francois, J., primary and Leduc, G., additional
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120. Adaptive applications over active networks: case study on layered multicast
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Yamamoto, L., primary and Leduc, G., additional
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121. Decentralized local backup LSP calculation with efficient bandwidth sharing
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Melon, L., primary, Blanchy, F., additional, and Leduc, G., additional
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122. Routing in a MPLS network featuring preemption mechanisms
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Blanchy, F., primary, Melon, L., additional, and Leduc, G., additional
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123. Multiple Description Coding versus Transport Layer FEC for Resilient Video Transmission
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Soldani, C., primary, Leduc, G., additional, Verdicchio, F., additional, and Munteanu, A., additional
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124. Improving wear time compliance with a 24-hour waist-worn accelerometer protocol in the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE)
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Tudor Locke, C., Barreira, T. V., Schuna, J. M., Mire, E. F., Chaput, J. P., Fogelholm, M., Hu, G., Kuriyan, R., Kurpad, A., Lambert, E. V., Maher, C., Maia, J., Matsudo, V., Olds, T., Onywera, V., Sarmiento, O. L., Standage, M., Tremblay, M. S., Zhao, P., Church, T. S., Katzmarzyk, P. T., Lambert, D. G., Barreira, T., Broyles, S., Butitta, B., Champagne, C., Cocreham, S., Dentro, K., Drazba, K., Harrington, D., Johnson, W., Milauskas, D., Mire, E., Tohme, A., Rodarte, R., Amoroso, B., Luopa, J., Neiberg, R., Rushing, S., Lewis, L., Ferrar, K., Physio, B., Georgiadis, E., Stanley, R., Matsudo, V. K. R., Matsudo, S., Araujo, T., de Oliveira, L. C., Rezende, L., Fabiano, L., Bezerra, D., Ferrari, G., Bélanger, P., Borghese, M., Boyer, C., Leblanc, A., Francis, C., Leduc, G., Diao, C., Li, W., Liu, E., Liu, G., Liu, H., Ma, J., Qiao, Y., Tian, H., Wang, Y., Zhang, T., Zhang, F., Sarmiento, O., Acosta, J., Alvira, Y., Diaz, M. P., Gamez, R., Garcia, M. P., Gómez, L. G., Gonzalez, L., Gonzalez, S., Grijalba, C., Gutierrez, L., Leal, D., Lemus, N., Mahecha, E., Mahecha, M. P., Mahecha, R., Ramirez, A., Rios, P., Suarez, A., Triana, C., Hovi, E., Kivelä, J., Räsänen, S., Roito, S., Saloheimo, T., Valta, L., Lokesh, D. P., D'Almeida, M. S., Annie Mattilda, R., Correa, L., Vijay, D., Wachira, L. J., Muthuri, S., da Silva Borges, A., Oliveira Sá Cachada, S., de Chaves, R. N., Gomes, T. N. Q. F., Pereira, S. I. S., de Vilhena e. Santos, D. M., dos Santos, F. K., Rodrigues da Silva, P. G., de Souza, M. C., Lambert, V., April, M., Uys, M., Naidoo, N., Synyanya, N., Carstens, M., Donatto, S., Lemon, C., Jackson, A., Pearson, A., Pennington, G., Ragus, D., Roubion, R., Schuna, J., Wiltz, D., Batterham, A., Kerr, J., Pratt, M., Pietrobelli, Angelo, ISCOLE Research Group, Tudor-Locke, Catrine, Barreira, Tiago V, Schuna, John M, Mire, Emily F, Maher, Carol A, Olds, Timothy S, Katzmarzyk, Peter T, University of Helsinki, Department of Food and Nutrition, Nutrition Science, MRC/UCT RU for Exercise and Sport Medicine, and Faculty of Health Sciences
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Male ,Gerontology ,Pediatric Obesity ,Time Factors ,Accelerometry, Exercise, Measurement, Physical activity, Sedentary time, Pediatrics ,Medicine (miscellaneous) ,RA773 ,Accelerometer ,Pediatrics ,0302 clinical medicine ,Clinical Protocols ,Surveys and Questionnaires ,Accelerometry ,030212 general & internal medicine ,315 Sport and fitness sciences ,Child ,Measurement ,Nutrition and Dietetics ,ALGORITHMS ,Nutrition Surveys ,16. Peace & justice ,3. Good health ,Sedentary time ,Female ,medicine.medical_specialty ,Waist ,National Health and Nutrition Examination Survey ,Physical activity ,Physical Therapy, Sports Therapy and Rehabilitation ,Motor Activity ,Childhood obesity ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,medicine ,Humans ,WRIST ,Accelerometer data ,Wakefulness ,Life Style ,Exercise ,Protocol (science) ,HIP ,business.industry ,Methodology ,030229 sport sciences ,medicine.disease ,United States ,PHYSICAL-ACTIVITY ,Physical therapy ,Sleep ,business - Abstract
Background We compared 24-hour waist-worn accelerometer wear time characteristics of 9–11 year old children in the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE) to similarly aged U.S. children providing waking-hours waist-worn accelerometer data in the 2003–2006 National Health and Nutrition Examination Survey (NHANES). Methods Valid cases were defined as having ≥4 days with ≥10 hours of waking wear time in a 24-hour period, including one weekend day. Previously published algorithms for extracting total sleep episode time from 24-hour accelerometer data and for identifying wear time (in both the 24-hour and waking-hours protocols) were applied. The number of valid days obtained and a ratio (percent) of valid cases to the number of participants originally wearing an accelerometer were computed for both ISCOLE and NHANES. Given the two surveys’ discrepant sampling designs, wear time (minutes/day, hours/day) from U.S. ISCOLE was compared to NHANES using a meta-analytic approach. Wear time for the 11 additional countries participating in ISCOLE were graphically compared with NHANES. Results 491 U.S. ISCOLE children (9.92±0.03 years of age [M±SE]) and 586 NHANES children (10.43 ± 0.04 years of age) were deemed valid cases. The ratio of valid cases to the number of participants originally wearing an accelerometer was 76.7% in U.S. ISCOLE and 62.6% in NHANES. Wear time averaged 1357.0 ± 4.2 minutes per 24-hour day in ISCOLE. Waking wear time was 884.4 ± 2.2 minutes/day for U.S. ISCOLE children and 822.6 ± 4.3 minutes/day in NHANES children (difference = 61.8 minutes/day, p
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125. Multiple Description Coding versus Transport Layer FEC for Resilient Video Transmission.
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Soldani, C., Leduc, G., Verdicchio, F., and Munteanu, A.
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- 2006
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126. Decentralized local backup LSP calculation with efficient bandwidth sharing.
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Melon, L., Blanchy, F., and Leduc, G.
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- 2003
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127. Routing in a MPLS network featuring preemption mechanisms.
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Blanchy, F., Melon, L., and Leduc, G.
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- 2003
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128. Cycle-based TCP-friendly algorithm.
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Ait-Hellal, O., Yamamoto, L., and Leduc, G.
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- 1999
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129. Effects of chlorthalidone and metoprolol alone or in combination (Logroton) on blood pressure, lipids lipoproteins in hypertension
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Bielmann, P., Leduc, G., Lepage, J., and Davignon, J.
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- 1990
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130. Deleterious effects of cyanide on early life stages of Atlantic salmon (Salmo salar)
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Leduc, G.
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- 1978
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131. Seasonal changes of fat content in the yellow perch (Perca flavescens) of two Laurentian lakes
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Leduc, G. and Newsome, G. E.
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- 1975
132. Mlle. Liberty at 200.
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Leduc, G.
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FRENCH Revolution, 1789-1799 - Abstract
Discusses the activities of the bicentennial celebration of the French Revolution, as presented in `Le Soleil' of Quebec.
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- 1989
133. Anomalous water dynamics in brain: a combined diffusion magnetic resonance imaging and neutron scattering investigation
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C. Dolce, Bruno Demé, Jacques Ollivier, G. Leduc, Irina Piazza, Antonio Cupane, Judith Peters, Francesca Natali, Emmanuel L. Barbier, M Boehm, Calogero Stelletta, Institut Laue-Langevin (ILL), ILL, Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Università degli studi di Palermo - University of Palermo, Universita degli Studi di Padova, European Synchroton Radiation Facility [Grenoble] (ESRF), [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), Corvey-Biron, Sandrine, MIAI @ Grenoble Alpes - - MIAI2019 - ANR-19-P3IA-0003 - P3IA - VALID, Università degli Studi di Padova = University of Padua (Unipd), Natali F., Dolce C., Peters J., Stelletta C., Deme B., Ollivier J., Boehm M., Leduc G., Piazza I., Cupane A., and Barbier E.L.
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Medical diagnostic ,Materials science ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Quantitative Biology::Tissues and Organs ,Physics::Medical Physics ,Biomedical Engineering ,Biophysics ,proton dynamics ,Bioengineering ,brain imaging ,Neutron scattering ,Biochemistry ,Atomic units ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Tissue heterogeneity ,Water dynamics ,Nuclear magnetic resonance ,medicine ,Animals ,Diffusion (business) ,030304 developmental biology ,diffusion magnetic resonance imaging ,0303 health sciences ,Proton dynamic ,medicine.diagnostic_test ,neutron scattering ,Brain ,Water ,Magnetic resonance imaging ,water diffusion ,Life Sciences–Physics interface ,Magnetic Resonance Imaging ,Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin) ,Neutron Diffraction ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Bovine brain ,Brain imaging ,Diffusion magnetic resonance imaging ,Proton dynamics ,Water diffusion ,Cattle ,030217 neurology & neurosurgery ,Biotechnology - Abstract
International audience; Water diffusion is an optimal tool for investigating the architecture of brain tissue on which modern medical diagnostic imaging techniques rely. However, intrinsic tissue heterogeneity causes systematic deviations from pure free-water diffusion behaviour. To date, numerous theoretical and empirical approaches have been proposed to explain the non-Gaussian profile of this process. The aim of this work is to shed light on the physics piloting water diffusion in brain tissue at the micrometre-to-atomic scale. Combined diffusion magnetic resonance imaging and first pioneering neutron scattering experiments on bovine brain tissue have been performed in order to probe diffusion distances up to macromolecular separation. The coexistence of free-like and confined water populations in brain tissue extracted from a bovine right hemisphere has been revealed at the micrometre and atomic scale. The results are relevant for improving the modelling of the physics driving intra- and extracellular water diffusion in brain, with evident benefit for the diffusion magnetic resonance imaging technique, nowadays widely used to diagnose, at the micrometre scale, brain diseases such as ischemia and tumours.
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- 2019
134. A global multiproxy database for temperature reconstructions of the Common Era
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Dmitry Divine, Dmitriy V. Ovchinnikov, Hugues Goosse, Marit-Solveig Seidenkrantz, Anne Hormes, Narayan Prasad Gaire, Joelle Gergis, Katrine Husum, David J. Nash, Konrad Gajewski, Jens Zinke, Vladimir Mikhalenko, Darrell S. Kaufman, Eugene R. Wahl, Martin Grosjean, Nancy A. N. Bertler, Pierre Francus, Anastasia Gornostaeva, Diana Vladimirova, Kaustubh Thirumalai, Lucien von Gunten, Kevin J. Anchukaitis, Michael Sigl, Ryu Uemura, Michael N. Evans, Hideaki Motoyama, Scott St. George, Marie-Alexandrine Sicre, Chris S. M. Turney, Johannes P. Werner, Robert Mulvaney, Jianghao Wang, Brian M. Chase, Mark A. J. Curran, Julien Emile-Geay, Takeshi Nakatsuka, David J. Sauchyn, Nerilie J. Abram, Bronwyn C. Dixon, Raphael Neukom, Cody C. Routson, Trevor J. Porter, Selvaraj Kandasamy, Mirko Severi, Massimo Frezzotti, Steven J. Phipps, Hans W. Linderholm, A. E. Viau, P. Graham Mortyn, Jessica E. Tierney, Eric J. Steig, Heidi A. Roop, K. Halimeda Kilbourne, Jason A. Addison, Jonathan J. Tyler, Mandy Freund, Daniel A. Dixon, Belen Martrat, Chenxi Xu, Krystyna M. Saunders, Min Te Chen, Xuemei Shao, Vasile Ersek, Philipp Munz, Hans Oerter, Masaki Sano, Zhixin Hao, Meloth Thamban, Alexey A. Ekaykin, Barbara Stenni, Kazuho Horiuchi, Ignacio A. Mundo, Zicheng Yu, Gregory T. Pederson, James W. C. White, Nalan Koc, Elisabeth Isaksson, Kathryn Allen, Rixt de Jong, Jeannine-Marie St. Jacques, Andrew Lorrey, Guillaume Leduc, Quansheng Ge, Kristine L. DeLong, Kenji Kawamura, Anais Orsi, Thomas Opel, Edward R. Cook, Kate E. Sinclair, Benjamin J. Henley, Nicholas P. McKay, Helen McGregor, Andrew D. Moy, Elizabeth R. Thomas, Jesper Björklund, Helena L. Filipsson, Udya Kuwar Thapa, Casey Saenger, Northern Arizona University [Flagstaff], Australian National University (ANU), United States Geological Survey [Reston] (USGS), University of Maryland [College Park], University of Maryland System, Spanish National Research Council [Madrid] (CSIC), School of Biological, Earth and Environmental Sciences [Sydney] (BEES), University of New South Wales [Sydney] (UNSW), Oeschger Centre for Climate Change Research (OCCR), University of Bern, Dipartimento di Scienze Geologiche [Trieste], Università degli studi di Trieste, University of Texas at Austin [Austin], Department of Earth and Space Sciences [Seattle], University of Washington [Seattle], Department of Earth Sciences [Oxford], University of Oxford [Oxford], Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Climate Change Institute (CCI), University of Maine, University of Northumbria at Newcastle [United Kingdom], Lund University [Lund], Centre Eau Terre Environnement - INRS (INRS-ETE), Institut National de la Recherche Scientifique [Québec] (INRS), Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), Nepal Academy of Science and Technology, Université Catholique de Louvain (UCL), Quaternary Geology, The University Centre in Svalbard (UNIS), Norwegian Polar Institute, Climate and Environmental Physics [Bern] (CEP), Physikalisches Institut [Bern], Universität Bern [Bern]-Universität Bern [Bern], University of Maryland Center for Environmental Science, Horn Point Laboratory, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Universitat Autònoma de Barcelona [Barcelona] (UAB), National Institute of Polar Research [Tokyo] (NiPR), British Antarctic Survey (BAS), Natural Environment Research Council (NERC), School of Environment and Technology, University of Brighton, Abteilung Klinische Sozialmedizin, Berufs- und Umweltdermatologie, Universität Heidelberg [Heidelberg], Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo, Laboratoire de géographie physique : Environnements Quaternaires et Actuels (LGP), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Panthéon-Sorbonne (UP1), Aarhus University [Aarhus], Department of Chemistry, University of Florence (UNIFI), Biogéochimie-Traceurs-Paléoclimat (BTP), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), Paul Scherrer Institute (PSI), University of the Ryukyus [Okinawa], Australian Institute of Marine Science (AIMS), PAGES 2k, Università degli studi di Trieste = University of Trieste, University of Oxford, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Climate Change Institute [Orono] (CCI), Centre Eau Terre Environnement [Québec] (INRS - ETE), Université Catholique de Louvain = Catholic University of Louvain (UCL), Universität Bern [Bern] (UNIBE)-Universität Bern [Bern] (UNIBE), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universitat Autònoma de Barcelona (UAB), Universität Heidelberg [Heidelberg] = Heidelberg University, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Glaces et Continents, Climats et Isotopes Stables (GLACCIOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo (UTokyo), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Firenze = University of Florence (UniFI), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Emile-Geay, J., Mckay, N. P., Kaufman, D. S., Von Gunten, L., Wang, Junrong, Anchukaitis, K. J., Abram, N. J., Addison, J. A., Curran, M. A. J., Evans, M. N., Henley, B. J., Hao, Z., Martrat, B., Mcgregor, H. V., Neukom, R., Pederson, G. T., Stenni, B., Thirumalai, K., Werner, J. P., Xu, C., Divine, D. V., Dixon, B. C., Gergis, J., Mundo, I. A., Nakatsuka, T., Phipps, S. J., Routson, C. C., Steig, E. J., Tierney, J. E., Tyler, J. J., Allen, K. J., Bertler, N. A. N., Bjorklund, J., Chase, B. M., Chen, M. -T., Cook, E., De Jong, R., Delong, K. L., Dixon, D. A., Ekaykin, A. A., Ersek, V., Filipsson, H. L., Francus, P., Freund, M. B., Frezzotti, M., Gaire, N. P., Gajewski, K., Ge, Q., Goosse, H., Gornostaeva, A., Grosjean, M., Horiuchi, K., Hormes, A., Husum, K., Isaksson, E., Kandasamy, S., Kawamura, K., Kilbourne, K. H., Koc, N., Leduc, G., Linderholm, H. W., Lorrey, A. M., Mikhalenko, V., Mortyn, P. G., Motoyama, H., Moy, A. D., Mulvaney, R., Munz, P. M., Nash, D. J., Oerter, H., Opel, T., Orsi, A. J., Ovchinnikov, D. V., Porter, T. J., Roop, H. A., Saenger, C., Sano, M., Sauchyn, D., Saunders, K. M., Seidenkrantz, M. -S., Severi, M., Shao, X., Sicre, M. -A., Sigl, M., Sinclair, K., St George, S., St Jacques, J. -M., Thamban, M., Thapa, U. K., Thomas, E. R., Turney, C., Uemura, R., Viau, A. E., Vladimirova, D. O., Wahl, E. R., White, J. W. C., Yu, Z., Zinke, J., École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, and UCL - SST/ELI/ELIC - Earth & Climate
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Data Descriptor ,010504 meteorology & atmospheric sciences ,VDP::Mathematics and natural science: 400::Mathematics: 410::Statistics: 412 ,VDP::Matematikk og Naturvitenskap: 400::Matematikk: 410::Statistikk: 412 ,F800 ,computer.software_genre ,Palaeoclimate ,01 natural sciences ,Proxy (climate) ,CECI [CISM] ,calcification ,data integration objective ,Climate change ,trace metal analysis ,910 Geography & travel ,geography.geographical_feature_category ,Database ,G500 ,data acquisition system ,temperature of environmental material ,Computer Science Applications ,[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology ,Temperature reconstruction ,Statistics, Probability and Uncertainty ,Tree ring ,Geology ,wood ,Information Systems ,Statistics and Probability ,glacial ice ,radiance ,010506 paleontology ,observation design ,Library and Information Sciences ,archaeal metabolite ,Education ,time series design ,stable isotope analysis ,Dendrochronology ,550 Earth sciences & geology ,0105 earth and related environmental sciences ,geography ,Global temperature ,Glacier ,15. Life on land ,Sea surface temperature ,sediment ,13. Climate action ,North Atlantic oscillation ,Oceanic basin ,computer - Abstract
Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850-2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python., PAGES, a core project of Future Earth, is supported by the U.S. and Swiss National Science Foundations. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Some of this work was conducted as part of the North America 2k Working Group supported by the John Wesley Powell Center for Analysis and Synthesis, funded by the U.S. Geological Survey. B. Bauer, W. Gross, and E. Gille (NOAA National Centers for Environmental Information) are gratefully acknowledged for helping assemble the data citations and creating the NCEI versions of the PAGES 2k data records. We thank all the investigators whose commitment to data sharing enables the open science ethos embodied by this project.
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- 2017
135. New irradiation geometry for microbeam radiation therapy
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Elke Bräuer-Krisch, Herwig Requardt, Stéphanie Corde, Thierry Brochard, E.A. Siegbahn, Hans Blattmann, G. LeDuc, Jean A. Laissue, Pierrick Regnard, A. Bravin, Brauer-Krisch, E, Requardt, H, Regnard, P, Corde, S, Siegbahn, E, Leduc, G, Brochard, T, Blattmann, H, Laissue, J, and Bravin, A
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Materials science ,medicine.medical_treatment ,Normal tissue ,FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA) ,irradiation geometry, x-rays ,Geometry ,Radiation ,Radiation Dosage ,Microbeam radiation therapy ,High doses ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Irradiation ,Radiation Injuries ,Radiological and Ultrasound Technology ,Brain Neoplasms ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Brain ,Rats ,Radiation therapy ,Treatment Outcome ,Feasibility Studies ,Radiotherapy, Conformal ,Nuclear medicine ,business - Abstract
Microbeam radiation therapy (MRT) has the potential to treat infantile brain tumours when other kinds of radiotherapy would be excessively toxic to the developing normal brain. MRT uses extraordinarily high doses of x-rays but provides unusual resistance to radioneurotoxicity, presumably from the migration of endothelial cells from 'valleys' into 'peaks', i.e., into directly irradiated microslices of tissues. We present a novel irradiation geometry which results in a tolerable valley dose for the normal tissue and a decreased peak-to-valley dose ratio (PVDR) in the tumour area by applying an innovative cross-firing technique. We propose an MRT technique to orthogonally crossfire two arrays of parallel, nonintersecting, mutually interspersed microbeams that produces tumouricidal doses with small PVDRs where the arrays meet and tolerable radiation doses to normal tissues between the microbeams proximal and distal to the tumour in the paths of the arrays.
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- 2005
136. Exploiting geometrical irradiation possibilities in MRT application
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Pierrick Regnard, Elke Bräuer-Krisch, Herwig Requardt, Hans Blattmann, Stéphanie Corde, Alberto Bravin, E.A. Siegbahn, Jean A. Laissue, G. LeDuc, Brauer-Krisch, E, Requardt, H, Regnard, P, Corde, S, Siegbahn, E, Leduc, G, Blattmann, H, Laissue, J, and Bravin, A
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Cross-firing ,Physics ,Nuclear and High Energy Physics ,Synchrotron radiation ,business.industry ,medicine.medical_treatment ,Normal tissue ,FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA) ,Radiation ,Radiation therapy ,Optics ,Microbeam radiation therapy ,medicine ,High doses ,Irradiation ,business ,Instrumentation ,Biomedical engineering - Abstract
Microbeam Radiation Therapy (MRT) has the potential to treat infantile brain tumors when other kinds of radiotherapy would be excessively toxic to the developing normal brain. MRT uses extraordinarily high doses of X-rays but provides unusual resistance to radioneurotoxicity, presumably from the rapid migration of regenerative endothelial cells from dose “valleys” into dose “peaks”, i.e., into directly irradiated micro-slices of tissues. We will present a novel irradiation geometry which results in a tolerable valley dose for the normal tissue and a decreased peak-to-valley dose ratio (PVDR) in the tumor area by applying an innovative cross-firing technique. We propose an MRT technique to orthogonally crossfire two arrays of parallel, nonintersecting, mutually interspersed microbeams that produces tumoricidal doses with small PVDRs where the arrays meet and tolerable radiation doses to normal tissues between the microbeams proximal and distal to the tumor in the paths of the arrays.
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- 2005
137. Ceramic fiber modular assemblies for lining furnace walls
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Leduc, G
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- 1984
138. Estimating COVID-19 vaccine uptake and its drivers among migrants, homeless and precariously housed people in France.
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Roederer T, Mollo B, Vincent C, Leduc G, Sayyad-Hilario J, Mosnier M, and Vandentorren S
- Abstract
Background: Migrants, people experiencing homelessness (PEH), or precariously housed (PH) are at high risk for COVID-19 infection, hospitalization, and death from COVID-19. However, while data on COVID-19 vaccine uptake in these populations are available in the USA, Canada, and Denmark, we are lacking, to the best of our knowledge, data from France., Methods: In late 2021, we carried out a cross-sectional survey to determine COVID-19 vaccine coverage in PEH/PH residing in Ile-de-France and Marseille, France, and to explore its drivers. Participants aged over 18 years were interviewed face-to-face where they slept the previous night, in their preferred language, and then stratified for analysis into three housing groups (Streets, Accommodated, and Precariously Housed). Standardized vaccination rates were computed and compared to the French population. Multilevel univariate and multivariable logistic regression models were built., Results: We find that 76.2% (95% confidence interval [CI] 74.3-78.1) of the 3690 participants received at least one COVID-19 vaccine dose while 91.1% of the French population did so. Vaccine uptake varies by stratum, with the highest uptake (85.6%; reference) in PH, followed by Accommodated (75.4%; adjusted odds-ratio = 0.79; 95% CI 0.51-1.09 vs. PH) and lowest in Streets (42.0%; AOR = 0.38; 95%CI 0.25-0.57 vs. PH). Use for vaccine certificate, age, socioeconomic factors, and vaccine hesitancy is associated with vaccination coverage., Conclusions: In France, PEH/PH, and especially the most excluded, are less likely than the general population to receive COVID-19 vaccines. While vaccine mandate has proved an effective strategy, targeted outreach, on-site vaccinations, and sensitization activities are strategies enhancing vaccine uptake that can easily be replicated in future campaigns and other settings., (© 2023. The Author(s).)
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- 2023
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139. Antimicrobial Resistance and Genetic Diversity of Pseudomonas aeruginosa Strains Isolated from Equine and Other Veterinary Samples.
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Pottier M, Castagnet S, Gravey F, Leduc G, Sévin C, Petry S, Giard JC, Le Hello S, and Léon A
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Pseudomonas aeruginosa is one of the leading causes of healthcare-associated infections in humans. This bacterium is less represented in veterinary medicine, despite causing difficult-to-treat infections due to its capacity to acquire antimicrobial resistance, produce biofilms, and persist in the environment, along with its limited number of veterinary antibiotic therapies. Here, we explored susceptibility profiles to antibiotics and to didecyldimethylammonium chloride (DDAC), a quaternary ammonium widely used as a disinfectant, in 168 P. aeruginosa strains isolated from animals, mainly Equidae. A genomic study was performed on 41 of these strains to determine their serotype, sequence type (ST), relatedness, and resistome. Overall, 7.7% of animal strains were resistant to carbapenems, 10.1% presented a multidrug-resistant (MDR) profile, and 11.3% showed decreased susceptibility (DS) to DDAC. Genomic analyses revealed that the study population was diverse, and 4.9% were ST235, which is considered the most relevant human high-risk clone worldwide. This study found P. aeruginosa populations with carbapenem resistance, multidrug resistance, and DS to DDAC in equine and canine isolates. These strains, which are not susceptible to antibiotics used in veterinary and human medicine, warrant close the setting up of a clone monitoring, based on that already in place in human medicine, in a one-health approach.
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- 2022
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140. Evaluation of Real-life Use of Point-of-care Rapid Antigen Testing for SARS-CoV-2 in Schools (EPOCRATES): a cohort study.
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Blanchard AC, Desforges M, Labbé AC, Nguyen CT, Petit Y, Besner D, Zinszer K, Séguin O, Laghdir Z, Adams K, Benoit MÈ, Leduc G, Longtin J, Ragoussis J, Buckeridge DL, and Quach C
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- Humans, Cohort Studies, Point-of-Care Systems, Prospective Studies, SARS-CoV-2 genetics, COVID-19 diagnosis, COVID-19 epidemiology
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Background: SARS-CoV-2 transmission has an impact on education. In this study, we assessed the performance of rapid antigen detection tests (RADTs) versus polymerase chain reaction (PCR) for the diagnosis of SARS-CoV-2 infection in school settings, and RADT use for monitoring exposed contacts., Methods: In this real-world, prospective observational cohort study, high-school students and staff were recruited from 2 high schools in Montréal, Canada, and followed from Jan. 25 to June 10, 2021. Twenty-five percent of asymptomatic participants were tested weekly by RADT (nasal) and PCR (gargle). Class contacts of cases were tested. Symptomatic participants were tested by RADT (nasal) and PCR (nasal and gargle). The number of cases and outbreaks were compared with those of other high schools in the same area., Results: Overall, 2099 students and 286 school staff members consented to participate. The overall specificity of RADTs varied from 99.8% to 100%, with a lower sensitivity, varying from 28.6% in asymptomatic to 83.3% in symptomatic participants. Secondary cases were identified in 10 of 35 classes. Returning students to school after a 7-day quarantine, with a negative PCR result on days 6-7 after exposure, did not lead to subsequent outbreaks. Of cases for whom the source was known, 37 of 51 (72.5%) were secondary to household transmission, 13 (25.5%) to intraschool transmission, and 1 to community contacts between students in the same school., Interpretation: Rapid antigen detection tests did not perform well compared with PCR in asymptomatic individuals. Reinforcing policies for symptom screening when entering schools and testing symptomatic individuals with RADTs on the spot may avoid subsequent substantial exposures in class. Preprint: medRxiv - doi.org/10.1101/2021.10.13.21264960., Competing Interests: Competing interests: Ana Blanchard reports project grants from Réseau de recherche en Santé Respiratoire du Québec and Cystic Fibrosis Foundation (payments to Centre Hospitalier Universitaire Sainte-Justine). Annie-Claude Labbé reports honoraria for a lecture from Hologic, speakers honoraria from Merck and Pfizer, and provision of reagents for SARS-CoV-2 testing from Seegene, DiaSorin and Roche Diagnostics, as part of another study. Kate Zinszer reports grant funding from the Public Health Agency of Canada, Canadian Institutes of Health Research and Fonds de Recherche du Québec — Santé. Caroline Quach reports a project grant from Ministère de la Santé et des Services sociaux — Québec (payments to Centre Hospitalier Universitaire Sainte-Justine). No other competing interests were declared., (© 2022 CMA Impact Inc. or its licensors.)
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- 2022
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141. AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway.
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Sun H, Cai H, Xu C, Zhai H, Lux F, Xie Y, Feng L, Du L, Liu Y, Sun X, Wang Q, Song H, He N, Zhang M, Ji K, Wang J, Gu Y, Leduc G, Doussineau T, Wang Y, Liu Q, and Tillement O
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- Gadolinium, Humans, NF-E2-Related Factor 2, Radiation, Ionizing, Signal Transduction, Nanoparticles therapeutic use, Neoplasms drug therapy, Radiation-Sensitizing Agents
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In the frame of radiotherapy treatment of cancer, radioresistance remains a major issue that still needs solutions to be overcome. To effectively improve the radiosensitivity of tumors and reduce the damage of radiation to neighboring normal tissues, radiosensitizers have been given increasing attention in recent years. As nanoparticles based on the metal element gadolinium, AGuIX nanoparticles have been shown to increase the radiosensitivity of cancers. Although it is a rare nanomaterial that has entered preclinical trials, the unclear biological mechanism hinders its further clinical application. In this study, we demonstrated the effectiveness of AGuIX nanoparticles in the radiosensitization of triple-negative breast cancer. We found that AGuIX nanoparticles increased the level of DNA damage by compromising the homologous recombination repair pathway instead of the non-homologous end joining pathway. Moreover, the results showed that AGuIX nanoparticles induced apoptosis, but the degree of apoptosis ability was very low, which cannot fully explain their strong radiosensitizing effect. Ferroptosis, the other mode of cell death, was also discovered to play a significant role in radiation sensitization, and AGuIX nanoparticles may regulate the anti-ferroptosis system by inhibiting the NRF2-GSH-GPX4 signaling pathway., (© 2022. The Author(s).)
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- 2022
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142. Tolerance of Normal Rabbit Facial Bones and Teeth to Synchrotron X-Ray Microbeam Irradiation.
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Laissue JA, Barré S, Bartzsch S, Blattmann H, Bouchet AM, Djonov VG, Haberthür D, Hlushchuk R, Kaser-Hotz B, Laissue PP, LeDuc G, Reding SO, and Serduc R
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- Animals, Facial Bones, Rabbits, Synchrotrons, X-Rays, Neoplasms, Radiation Injuries, Radiosurgery
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Microbeam radiation therapy, an alternative radiosurgical treatment under preclinical investigation, aims to safely treat muzzle tumors in pet animals. This will require data on the largely unknown radiation toxicity of microbeam arrays for bones and teeth. To this end, the muzzle of six young adult New Zealand rabbits was irradiated by a lateral array of microplanar beamlets with peak entrance doses of 200, 330 or 500 Gy. The muzzles were examined 431 days postirradiation by computed microtomographic imaging (micro-CT) ex vivo, and extensive histopathology. The boundaries of the radiation field were identified histologically by microbeam tracks in cartilage and other tissues. There was no radionecrosis of facial bones in any rabbit. Conversely, normal incisor teeth exposed to peak entrance doses of 330 Gy or 500 Gy developed marked caries-like damage, whereas the incisors of the two rabbits exposed to 200 Gy remained unscathed. A single, unidirectional array of microbeams with a peak entrance dose ≤200 Gy (valley dose14 Gy) did not damage normal bone, teeth and soft tissues of the muzzle of normal rabbits longer than one year after irradiation. Because of that, Microbeam radiation therapy of muzzle tumors in pet animals is unlikely to cause sizeable damage to normal teeth, bone and soft tissues, if a single array as used here delivers a limited entrance dose of 200 Gy and a valley dose of ≤14 Gy., (©2022 by Radiation Research Society. All rights of reproduction in any form reserved.)
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- 2022
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143. Body Size Misperception and Dissatisfaction in Elementary School Children.
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Bordeleau M, Leduc G, Blanchet C, Drapeau V, and Alméras N
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- Body Mass Index, Body Size, Body Weight, Child, Child, Preschool, Female, Humans, Male, Overweight, Schools, Body Image, Pediatric Obesity epidemiology
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Background: To examine the association between body size perception (BSP) and body size dissatisfaction (BSD) in elementary school children and to document the potential contribution of individual factors [age, sex, and actual body size (BMI Z -scores: BMI Z )] that may influence their relationship. Methods: This study included 269 children (124 boys and 145 girls) between 6 and 13 years of age (9.2 ± 1.6 years). The BSP score was calculated as the difference between the perceived actual body size and BMI Z (actual body size). A negative BSP score indicated an underestimation of their body size. To assess the BSD score, the difference between perceived actual body size and desired body size was calculated. A positive BSD score indicated a desire to be thinner. Results: Perceived actual body size was smaller than BMI Z , independent of age group and weight status. Overall, 64% of children underestimated their body size. The young children living with obesity demonstrated the highest misperception. Results also showed that the proportion of children who desired to be thinner was higher in overweight and obese subgroups. No significant relationship was found between BSP and BSD scores in the entire sample, while a positive association was observed among younger children in the normal-weight and obese subgroups ( r = 0.40; p < 0.001 and r = 0.78; p < 0.05, respectively). Conclusions: Underestimation and dissatisfaction of body size are more prevalent in children living with overweight/obesity. Moreover, there is an association between BSP and dissatisfaction, yet this association is dependent on age and weight status.
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- 2021
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144. The FitSpirit approach for increasing physical activity in canadian teenage girls: protocol of a longitudinal, quasi-experimental study.
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Leduc G, Gilbert JA, Ayotte A, Moreau N, Drapeau V, Lemoyne J, Monthuy-Blanc J, Tremblay J, and Mathieu ME
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- Adolescent, Canada, Child, Cross-Sectional Studies, Female, Humans, Life Style, School Health Services, Exercise, Schools
- Abstract
Background: Worldwide, most adolescent girls do not meet physical activity (PA) recommendations and very few PA programs are tailored specifically towards them. Even fewer information exists about the long-term effects of such programs. Some Canadian schools have implemented the FitSpirit PA intervention designed specifically for girls aged 12 to 17 years old. This paper describes the protocol of a quasi-experimental study evaluating long-term changes in health behaviours and outcomes following FitSpirit participation., Methods: The study is conducted among schools that partner with FitSpirit every year. It started in 2018 and will be completed in 2022. The intervention comprises motivational talks, a turnkey running program, PA sessions and special events. Study participants fill out an online questionnaire twice a year. Follow-up questionnaires are sent at the end of each school year to the study participants who dropout from FitSpirit. The main outcome, changes in PA levels, is evaluated using questions validated for adolescents. Secondary outcomes are health (perceived health); lifestyle habits (sedentary activities, eating and sleeping habits); psychosocial outcomes (physical self-efficacy and body satisfaction); and FitSpirit appreciation (activity participation and satisfaction). Most questions originate from questionnaires validated for the adolescent population. Cross-sectional and longitudinal analyses will be performed., Discussion: This study will provide one of the first longitudinal reports on the impact of a large extra-curricular PA intervention designed specifically for adolescent girls. The current study will uniquely contribute to PA research by assessing outcomes additional to PA levels, including markers of health, lifestyle habits and psychosocial determinants., Trial Registration: NCT, NCT03804151 , Registered on January 22, 2019; retrospectively registered.
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- 2021
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145. Thermal tolerance and fish heart integrity: fatty acids profiles as predictors of species resilience.
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Christen F, Dufresne F, Leduc G, Dupont-Cyr BA, Vandenberg GW, Le François NR, Tardif JC, Lamarre SG, and Blier PU
- Abstract
The cardiovascular system is a major limiting system in thermal adaptation, but the exact physiological mechanisms underlying responses to thermal stress are still not completely understood. Recent studies have uncovered the possible role of reactive oxygen species production rates of heart mitochondria in determining species' upper thermal limits. The present study examines the relationship between individual response to a thermal challenge test (CT
max ), susceptibility to peroxidation of membrane lipids, heart fatty acid profiles and cardiac antioxidant enzyme activities in two salmonid species from different thermal habitats ( Salvelinus alpinus , Salvelinus fontinalis ) and their hybrids. The susceptibility to peroxidation of membranes in the heart was negatively correlated with individual thermal tolerance. The same relationship was found for arachidonic and eicosapentaenoic acid. Total H2 O2 buffering activity of the heart muscle was higher for the group with high thermal resistance. These findings underline a potential general causative relationship between sensitivity to oxidative stress, specific fatty acids, antioxidant activity in the cardiac muscle and thermal tolerance in fish and likely other ectotherms. Heart fatty acid profile could be indicative of species resilience to global change, and more importantly the plasticity of this trait could predict the adaptability of fish species or populations to changes in environmental temperature., (© The Author(s) 2020. Published by Oxford University Press and the Society for Experimental Biology.)- Published
- 2020
- Full Text
- View/download PDF
146. Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer.
- Author
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Du Y, Sun H, Lux F, Xie Y, Du L, Xu C, Zhang H, He N, Wang J, Liu Y, Leduc G, Doussineau T, Ji K, Wang Q, Lin Z, Wang Y, Liu Q, and Tillement O
- Subjects
- Animals, Antineoplastic Agents chemistry, Antineoplastic Agents radiation effects, Apoptosis drug effects, Carcinoma, Non-Small-Cell Lung pathology, Cell Line, Tumor, DNA Breaks, Double-Stranded drug effects, DNA Repair drug effects, Gadolinium chemistry, Gadolinium radiation effects, Humans, Lung pathology, Lung Neoplasms pathology, Male, Metal Nanoparticles chemistry, Metal Nanoparticles radiation effects, Mice, Nude, Radiation, Ionizing, Radiation-Sensitizing Agents chemistry, Radiation-Sensitizing Agents radiation effects, Xenograft Model Antitumor Assays, Antineoplastic Agents therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, Metal Nanoparticles therapeutic use, Radiation-Sensitizing Agents therapeutic use
- Abstract
Radiotherapy is the main treatment for cancer patients. A major concern in radiotherapy is the radiation resistance of some tumors, such as human nonsmall cell lung cancer. However, the radiation dose delivered to the tumors is often limited by the possibility of collateral damage to surrounding healthy tissues. A new and efficient gadolinium-based nanoparticle, AGuIX, has recently been developed for magnetic resonance imaging-guided radiotherapy and has been proven to act as an efficient radiosensitizer. The amplified radiation effects of AGuIX nanoparticles appear to be due to the emission of low-energy photoelectrons and Auger electron interactions. We demonstrated that AGuIX nanoparticles exacerbated radiation-induced DNA double-strand break damage and reduced DNA repair in the H1299 nonsmall cell lung cancer cell line. Furthermore, we observed a significant improvement in tumor cell damage and growth suppression, under radiation therapy, with the AGuIX nanoparticles in a H1299 mouse xenograft model. This study paves the way for research into the radiosensitization mechanism of AGuIX nanoparticles and provides a scientific basis for the use of AGuIX nanoparticles as radiosensitizing drugs.
- Published
- 2020
- Full Text
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147. Sleep Difficulties in Preschoolers with Psychiatric Diagnoses.
- Author
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Chénier-Leduc G, Béliveau MJ, Dubois-Comtois K, Butler B, Berthiaume C, and Pennestri MH
- Subjects
- Child, Child, Preschool, Female, Humans, Infant, Male, Parents psychology, Perception, Prevalence, Sleep, Mental Disorders complications, Sleep Wake Disorders complications
- Abstract
Background: Sleep problems among preschoolers are highly prevalent. Given the impact of poor sleep quality on development, this relationship is particularly relevant in vulnerable populations but is less documented. This study aims to document parental perception of sleep problems in preschoolers assessed in a psychiatric clinic, as a function of diagnosis type. Methods: Children (14-71 months, n = 228) were evaluated by a psychiatrist, and diagnoses were pooled into four categories: behavioral disorders, relational disorders/psychosocial problems, developmental coordination disorder (DCD), and communication disorders. Sleep problems were measured using the Child Behavior Checklist (CBCL). Results: In this clinical sample of preschoolers, 21.6% of children were identified as having a sleep problem by their parents. Behavioral disorders and communication disorders were associated with increased parental report of sleep problems (respectively, trouble falling asleep and nighttime awakenings), while DCD was associated with lower parental report of sleep problems (fewer nighttime awakenings and less difficulty falling asleep) ( p < 0.05). Relational disorders were not associated with parental reports of sleep difficulties ( p > 0.05). Moreover, some psychiatric categories were associated with specific sleep symptoms (such as difficulty falling asleep and night awakenings). Conclusion : Parents of preschoolers with behavioral disorders and communication disorders are more likely to report sleep problems in their children than parents of preschoolers with DCD and relational disorders. Since different categories of psychiatric disorders are associated with specific types of sleep complaints, screening, and treatment should be adapted accordingly.
- Published
- 2019
- Full Text
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148. Brain lateralization probed by water diffusion at the atomic to micrometric scale.
- Author
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Natali F, Dolce C, Peters J, Stelletta C, Demé B, Ollivier J, Leduc G, Cupane A, and Barbier EL
- Subjects
- Animals, Cattle, Myelin Sheath ultrastructure, Cerebellum diagnostic imaging, Cerebrum diagnostic imaging, Diffusion Magnetic Resonance Imaging methods, Dominance, Cerebral, Facilitated Diffusion physiology, Neutron Diffraction methods, Scattering, Small Angle, Water chemistry
- Abstract
Combined neutron scattering and diffusion nuclear magnetic resonance experiments have been used to reveal significant interregional asymmetries (lateralization) in bovine brain hemispheres in terms of myelin arrangement and water dynamics at micron to atomic scales. Thicker myelin sheaths were found in the left hemisphere using neutron diffraction. 4.7 T dMRI and quasi-elastic neutron experiments highlighted significant differences in the properties of water dynamics in the two hemispheres. The results were interpreted in terms of hemisphere-dependent cellular composition (number of neurons, cell distribution, etc.) as well as specificity of neurological functions (such as preferential networking).
- Published
- 2019
- Full Text
- View/download PDF
149. [Influence of clinical and pathological factors on lymph node harvesting in surgical specimens of colorectal cancer].
- Author
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Leduc G, Bawin M, Kesteman M, Mutijima E, Maes N, Coimbra C, Delvenne P, and Somja J
- Subjects
- Humans, Neoplasm Staging, Colorectal Neoplasms pathology, Lymph Node Excision methods, Lymphatic Metastasis diagnosis
- Abstract
In colorectal cancer staging, pathologic lymph node analysis is a crucial information for the clinician and must be performed with a maximal level of accuracy. Therefore, the surgical sample analysis needs harvesting of as many lymph nodes as possible from the mesentery. In this study, we analysed the influence of a series of clinical and pathological factors which could influence lymph node harvesting. A total of 239 patients were included in our study. The factors with a statistically significant influence on lymph node collection (pinferior to0.05) were the age, gender of the patient, size of the primitive neoplasm, size of the surgical specimen, expertise of the surgeon and the pathology department. The presence of a radiochimiotherapy did not have any influence on the lymph node collection. This study highlights the importance of lymph node harvesting in colorectal surgical specimens of colo-rectal cancers.
- Published
- 2019
150. Anomalous water dynamics in brain: a combined diffusion magnetic resonance imaging and neutron scattering investigation.
- Author
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Natali F, Dolce C, Peters J, Stelletta C, Demé B, Ollivier J, Boehm M, Leduc G, Piazza I, Cupane A, and Barbier EL
- Subjects
- Animals, Brain physiology, Cattle physiology, Magnetic Resonance Imaging, Neutron Diffraction, Water metabolism
- Abstract
Water diffusion is an optimal tool for investigating the architecture of brain tissue on which modern medical diagnostic imaging techniques rely. However, intrinsic tissue heterogeneity causes systematic deviations from pure free-water diffusion behaviour. To date, numerous theoretical and empirical approaches have been proposed to explain the non-Gaussian profile of this process. The aim of this work is to shed light on the physics piloting water diffusion in brain tissue at the micrometre-to-atomic scale. Combined diffusion magnetic resonance imaging and first pioneering neutron scattering experiments on bovine brain tissue have been performed in order to probe diffusion distances up to macromolecular separation. The coexistence of free-like and confined water populations in brain tissue extracted from a bovine right hemisphere has been revealed at the micrometre and atomic scale. The results are relevant for improving the modelling of the physics driving intra- and extracellular water diffusion in brain, with evident benefit for the diffusion magnetic resonance imaging technique, nowadays widely used to diagnose, at the micrometre scale, brain diseases such as ischemia and tumours.
- Published
- 2019
- Full Text
- View/download PDF
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