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We describe the case of a wounded soldier with a gluteus infection from which Leclercia adecarboxylata was cultured. To our knowledge, this is only the second report of this unusual pathogen being isolated from an abscess and the first report of L. adecarboxylata as the etiology of a war wound infection.

The epidemiology, etiology and outcome of neonatal sepsis are changing over time. While monitoring longitudinal trends in neonatal sepsis in our institution, we encountered a case of late-onset neonatal sepsis due to Leclercia adecarboxylata. A Gram-negative rod previously not encountered in the clinical setting, L. adecarboxylata has recently emerged as a human pathogen, primarily in immunosuppressed patients. This report describes the clinical and laboratory features of this case of late-onset L. adecarboxylata sepsis, and reviews significant features of infection associated with this emerging pathogen.

Leclercia adecarboxylata es una enterobacteriácea reportada ocasionalmente como un germen oportunista que compromete pacientes con algún tipo de inmunosupresión como neutropenia, cirrosis o cáncer. Se reporta un brote de cinco casos de bacteriemia por L. adecarboxylata en pacientes con diversas condiciones de inmunosupresión, probablemente asociado con el uso de viales de heparina contaminados. Se hace una revisión actualizada de la literatura y una discusión sobre los aspectos particulares del brote y del microorganismo. Leclercia adecarboxylata is part of the Enterobacteriaceae family occasionally reported as an opportunist microorganism in patients with any kind of immunosuppression as neutropenia, cirrhosis or cancer. We report an outbreak with five cases of Leclercia adecarboxylata bacteremia in patients with several immune conditions, most likely associated to contaminated heparin vials. We also present an updated literature review and discussion regarding the particular characteristics of the outbreak and the microorganism.

Leclercia adecarboxylata was isolated in pure culture from a peritonsillar and lateral pharyngeal abscess in an immunocompetent host. To our knowledge, this is the first case of infection caused by this microorganism being found in an odontogenic area of the head and neck.

Leclercia adecarboxylata, a motile, gram-negative bacillus of the enterobacteriaceae family, is rarely recovered as a pathogen. We report an exceptionally rare case of L. adecarboxylata endocarditis complicated by embolization of the kidney and spleen in a 48-year-old woman with endometrial cancer. After 4 weeks of antimicrobial treatment, she recovered without sequelae.

Colorado potato beetle (CPB), Leptinotarsa decemlineata (Say), is an important pest on solanaceous crops worldwide. CPB has developed resistance to insecticides used for its control. In this study, in order to find a more effective and safer biological control agent against L. decemlineata, we studied the bacterial flora of CPB, and tested them for insecticidal effects on it. The highest insecticidal effect determined on L. decemlineata within 5 days was 100% and this effect was exhibited by Ld1 isolate. According to the morphological, physiological and biochemical tests, and 16S rRNA sequence homologies, Ld1 was identified as Leclercia adecarboxylata. This is the first time that this bacterium has been isolated from any insect pests. Our results indicate that Lecl. adecarboxylata may be valuable as a biological control agent for L. decemlineata.

Leclercia adecarboxylata is a rarely reported human pathogen, most commonly affecting immunocompromised individuals. In reported cases of immunocompetent patients infected with this organism, it is seen exclusively in the context of polymicrobial infections. We report here the case of an abscess in an immunocompetent patient that grew out L. adecarboxylata as a pure culture. The limited literature available on this organism is reviewed, and the potential implication of this finding is discussed.

Summary Enterobacter amnigenus and Leclercia adecarboxylata are Gram-negative aerobic bacilli of the family Enterobacteriaceae that have been isolated from water and, rarely, from various clinical specimens. Absidia is a filamentous fungus of the class Zygomycetes that is ubiquitous in nature and can cause infection, primarily in immunocompromised hosts. Here, we describe an infection of the left lower limb caused by E. amnigenus and L. adecarboxylata with subsequent isolation of Absidia spp. in a patient with multiple traumatic injuries after a major motor vehicle accident. The severity of the clinical picture made amputation necessary, despite aggressive anti-infective therapy with both antibacterial and antifungal agents. Prompt diagnosis and management are mandatory in order to minimize morbidity and even mortality, and reduce the social and economic cost.

Leclercia adecarboxylata is an opportunistic human pathogen that phenotypically resembles Escherichia coli. The natural susceptibilities of 101 Leclercia strains to 70 antimicrobial agents were investigated. MICs were determined with a microdilution procedure in cation-adjusted Mueller-Hinton broth (all strains) and IsoSensitest broth (some strains). Natural susceptibility patterns were assessed using German (DIN) standards (when applicable). In addition, biochemical properties recommended for the phenotypic identification of L. adecarboxylata were evaluated, applying two commercially available identification systems for Enterobacteriaceae and seven conventional tests. L. adecarboxylata strains were naturally sensitive to tetracyclines, aminoglycosides, all but two β-lactams, quinolones, folate pathway inhibitors, chloramphenicol, nitrofurantoin and azithromycin. They were naturally resistant to penicillin G, oxacillin, erythromycin, roxithromycin, clarithromycin, ketolides, lincosamides, streptogramins, linezolid, glycopeptides, rifampicin, fusidic acid and fosfomycin. There were only minor medium-dependent differences in susceptibility to most antibiotics. Lysine decarboxylase, malonate assimilation and acid production from arabitol and cellobiose, but not from adonitol and sorbitol, allowed definitive separation of L. adecarboxylata from E. coli. The results of this study form a database that can be applied to validate forthcoming antibiotic susceptibility tests of L. adecarboxylata, and might contribute to its reliable identification. Susceptibility patterns did not indicate obvious therapeutic difficulties for treatment of Leclercia infections. Special attention should be paid to biochemically aberrant leclerciae. Apart from biochemical features, fosfomycin susceptibility might be useful to differentiate between L. adecarboxylata and E. coli.

Leclercia adecarboxylata was isolated from a patient with a chronically inflamed gallbladder, together with Enterococcus sp. The organism was considered clinically significant and was susceptible to all antibiotics tested. Another strain of L. adecarboxylata was cultured from blood, together with Escherichia hermannii and E. faecalis , from a patient with sepsis.

Leclercia adecarboxylata is a rarely reported human pathogen, usually affecting immune compromised individuals. In the reported cases of immunocompetent patients infected with this organism, it is seen in the context with polymicrobial infections. Herein, we report the case of a para-ovarian abscess in a patient that grew L. adecarboxylata as a pure culture. The limited literature available on this organism is reviewed, and the potential implication of this finding is discussed.

Leclercia adecarboxylata, a gram-negative bacillus, is commonly seen in immuno-compromised patients and patients with polymicrobial wound infections.[1][1]–[7][2] Most L. adecarboxylata strains are naturally sensitive to all antimicrobial classes tested,[8][3] and successful treatment has been

A man in his early 80s presented to our emergency department with painless redness and swelling in his right leg. One week prior, he cleaned up floodwater in his basement after Hurricane Irene passed the Mid-Atlantic region of the USA in August 2011. Physical examination included large purple bullae and raised concern for necrotising fasciitis. Wound culture revealed a polymicrobial infection including Leclercia adecarboxylata.

A 5 year old boy with end-stage renal disease presented with clinical and laboratory findings of peritonitis. Peritoneal fluid revealed infection with Leclercia adecarboxylata. This is a motile, gram-negative bacillus, formerly designated enteric group 41 and Escherichia adecarboxylata. To our knowledge, this is the first reported case of peritonitis due to this organism.

Leclercia adecarboxylata는 1962년 Leclerc (1)에 의하여 처음으로 보고된 세균으로, 운동성이 있는 통성혐기성 그람 음성간균이다(2, 3). 이 세균은 음식이나 물 등의 환경에서 분리되며, 임상검체에서 분리되는 경우는 드물다(4). 임상검 체에서는 대부분의 경우 창상에서 발견되며 다른 균들과의 복합감염 형태로 흔히 나타나는 것으로 알려져 있으나, 면역 저하자의 혈류에서 단독으로 분리된 예가 보고되기도 한다 (4). 현재까지 전세계적으로 혈액, 객담 등의 검체에서 20여 건의 감염이 보고되었다(5-17). 국내에서는 말기 신부전 환 자의 복막투석액에서 이 균종에 의한 단독감염이 보고된 바 있고(4), 평활근 육종으로 항암 치료를 받은 환자의 혈액과 Hickman catheter에서 복합감염의 형태로 분리된 보고가 있다(18). 저자들은 2004년과 2007년에 L. adecarboxylata에 의한 단독감염 2예를 경험하였기에 보고한다.

ResumenLeclercia adecarboxylata es una enterobacteriácea reportada ocasionalmente como un germen oportunista que compromete pacientes con algún tipo de inmunosupresión como neutropenia, cirrosis o cáncer. Se reporta un brote de cinco casos de bacteriemia por L. adecarboxylata en pacientes con diversas condiciones de inmunosupresión, probablemente asociado con el uso de viales de heparina contaminados. Se hace una revisión actualizada de la literatura y una discusión sobre los aspectos particulares del brote y del microorganismo.AbstractLeclercia adecarboxylata is part of the Enterobacteriaceae family occasionally reported as an opportunist microorganism in patients with any kind of immunosuppression as neutropenia, cirrhosis or cancer. We report an outbreak with five cases of Leclercia adecarboxylata bacteremia in patients with several immune conditions, most likely associated to contaminated heparin vials. We also present an updated literature review and discussion regarding the particular characteristics of the outbreak and the microorganism.