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Traditionally, galaxy clusters have been expected to retain all the material accreted since their formation epoch. For this reason, their matter content should be representative of the Universe as a whole, and thus their baryon fraction should be close to the Universal baryon fraction b= m. We make use of the sample of the 100 brightest galaxy clusters discovered in the XXL Survey to investigate the fraction of baryons in the form of hot gas and stars in the cluster population. Since it spans a wide range of mass (1013-1015 M⊙) and redshift (0:05-1:1) and benefits from a large set of multiwavelength data, the XXL-100-GC sample is ideal for measuring the global baryon budget of massive halos. We measure the gas masses of the detected halos and use a mass-temperature relation directly calibrated using weak-lensing measurements for a subset of XXL clusters to estimate the halo mass. We find that the weak-lensing calibrated gas fraction of XXL-100-GC clusters is substantially lower than was found in previous studies using hydrostatic masses. Our best-fit relation between gas fraction and mass reads fgas;500 = 0:055+0:007 -0:006 M500=1014 M⊙ 0:21+0:11 -0:10. The baryon budget of galaxy clusters therefore falls short of the Universal baryon fraction by about a factor of two at r500;MT. Our measurements require a hydrostatic bias 1-b = MX=MWL = 0:72+0:08 -0:07 to match the gas fraction obtained using lensing and hydrostatic equilibrium, which holds independently of the instrument considered. Comparing our gas fraction measurements with the expectations from numerical simulations, we find that our results favour an extreme feedback scheme in which a significant fraction of the baryons are expelled from the cores of halos. This model is, however, in contrast with the thermodynamical properties of observed halos, which might suggest that weak-lensing masses are overestimated. In light of these results, we note that a mass bias 1 - b = 0:58 as required to reconcile Planck cosmic microwave background and cluster counts should translate into an even lower baryon fraction, which poses a major challenge to our current understanding of galaxy clusters. [ABSTRACT FROM AUTHOR]

Context: The XXL Survey is the largest homogeneous and contiguous survey carried out with XMM-Newton. Covering an area of 50 deg² distributed over two fields, it primarily investigates the large-scale structures of the Universe using the distribution of galaxy clusters and active galactic nuclei as tracers of the matter distribution. Aims: Given its depth and sky coverage, XXL is particularly suited to systematically unveiling the clustering of X-ray clusters and to identifying superstructures in a homogeneous X-ray sample down to the typical mass scale of a local massive cluster. Methods: A friends-of-friends algorithm in three-dimensional physical space was run to identify large-scale structures. In this paper we report the discovery of the highest redshift supercluster of galaxies found in the XXL Survey. We describe the X-ray properties of the clusters members of the structure and the optical follow-up. Results: The newly discovered supercluster is composed of six clusters of galaxies at a median redshift z ~ 0:43 and distributed across ~300×150 (10×5 Mpc) on the sky. This structure is very compact with all the clusters residing in oneXMMpointing; for this reason this is the first supercluster discovered with the XXL Survey. Photometric redshifts from the CFHTLS (Canada-France-Hawaii Telescope Legacy Survey) data release T0007 placed the supercluster at an approximate redshift of zphot ~ 0:45; subsequent spectroscopic follow-up with WHT (William Herschel Telescope) and NTT (New Technology Telescope) confirmed a median redshift of z ~ 0:43. An estimate of the X-ray mass and luminosity of this supercluster returns values of 1:7 × 1015 M⊙ and of 1:68 × 1044 erg s-1, respectively, and a total gas mass of Mgas = 9:3 × 1013 M⊙. These values put XLSSC-e at the average mass range of superclusters; its appearance, with two members of equal size, is quite unusual with respect to other superclusters and provides a unique view of the formation process of a massive structure. [ABSTRACT FROM AUTHOR]

Context: The XXL Survey is the largest survey carried out by XMM-Newton. Covering an area of 50 deg², the survey contains ~450 galaxy clusters out to a redshift ~2 and to an X-ray flux limit of ~5 × 10-15 erg s-1 cm-2. This paper is part of the first release of XXL results focussed on the bright cluster sample. Aims: We investigate the scaling relation between weak-lensing mass and X-ray temperature for the brightest clusters in XXL. The scaling relation discussed in this article is used to estimate the mass of all 100 clusters in XXL-100-GC. Methods: Based on a subsample of 38 objects that lie within the intersection of the northern XXL field and the publicly available CFHTLenS shear catalog, we derive the weak-lensing mass of each system with careful considerations of the systematics. The clusters lie at 0.1 < z < 0.6 and span a temperature range of T ⋍ 1-5 keV. We combine our sample with an additional 58 clusters from the literature, increasing the range to T ⋍ 1-10 keV. To date, this is the largest sample of clusters with weak-lensing mass measurements that has been used to study the mass-temperature relation. Results: The mass-temperature relation fit (M ∝ Tb) to the XXL clusters returns a slope b = 1.78+0.37 -0.32 and intrinsic scatter σlnM|T ⋍ 0.53; the scatter is dominated by disturbed clusters. The fit to the combined sample of 96 clusters is in tension with selfsimilarity, b = 1.67 ± 0.12 and σlnM|T ⋍ 0.41. Conclusions: Overall our results demonstrate the feasibility of ground-based weak-lensing scaling relation studies down to cool systems of ~1 keV temperature and highlight that the current data and samples are a limit to our statistical precision. As such we are unable to determine whether the validity of hydrostatic equilibrium is a function of halo mass. An enlarged sample of cool systems, deeper weak-lensing data, and robust modelling of the selection function will help to explore these issues further. [ABSTRACT FROM AUTHOR]

Galaxy clusters and groups are important cosmological probes and giant cosmic laboratories for studying galaxy evolution. Much effort has been devoted to understanding how and when baryonic matter cools at the centre of potential wells. However, a clear picture of the effciency with which baryons are converted into stars is still missing. We present the K-band luminosity-halo mass relation, LK;500 - M500;WL, for a subsample of 20 of the 100 brightest clusters in the XXL Survey observed with WIRCam at the Canada-France-Hawaii Telescope (CFHT). For the first time, we have measured this relation via weak-lensing analysis down to M500;WL = 3:5 × 1013 M⊙. This allows us to investigate whether the slope of the LK - M relation is different for groups and clusters, as seen in other works. The clusters in our sample span a wide range in mass, M500;WL = 0:35-12:10 × 1014 M⊙, at 0 < z < 0:6. The K-band luminosity scales as log10(LK;500=1012 L⊙) / ⊙ log10(M500;WL=1014 M⊙) with ⊙ = 0:85+0:35 -0:27 and an intrinsic scatter of ln LKjM = 0:37+0:19 -0:17. Combining our sample with some clusters in the Local Cluster Substructure Survey (LoCuSS) present in the literature, we obtain a slope of 1:05+0:16 -0:14 and an intrinsic scatter of 0:14+0:09 -0:07. The flattening in the LK - M seen in previous works is not seen here and might be a result of a bias in the mass measurement due to assumptions on the dynamical state of the systems. We also study the richness-mass relation and find that group-sized halos have more galaxies per unit halo mass than massive clusters. However, the brightest cluster galaxy (BCG) in low-mass systems contributes a greater fraction to the total cluster light than BCGs do in massive clusters; the luminosity gap between the two brightest galaxies is more prominent for group-sized halos. This result is a natural outcome of the hierarchical growth of structures, where massive galaxies form and gain mass within low-mass groups and are ultimately accreted into more massive clusters to become either part of the BCG or one of the brighter galaxies. [ABSTRACT FROM AUTHOR]

Studies attempting to describe fish community structure in shallow riverine environments typically rely on electrofishing and/or visual (snorkelling) surveys, but few have addressed the relative efficiencies of these two methods at estimating fish density and biomass across wide ranges of geography, taxonomy and life history stages. Multiple paired electrofishing and visual surveys were conducted in 18 temperate Canadian rivers in order to obtain community-wide density and biomass estimates from both methods. Partial canonical multivariate analyses were applied to the paired fish community matrices comparing the results of both surveying methods at the taxonomic levels of family, genus and species, as well as size classes within families and species, to assess the particular effectiveness of each sampling method. Although electrofishing estimates of family and species richness were generally greater, snorkelling surveys tended to generate higher density and biomass estimates for different size classes of many salmonid and cyprinid species. Moreover, mean river biomass estimates derived from visual surveying matched those obtained from our best mean river biomass estimates arising from the two methods combined. This study provides empirical evidence that electrofishing and visual survey methods generate different types of information when assessing fish community structure at the family level or by size classes. Our results provide ample background information for determining the most accurate sampling method for a particular fish community assemblage, which is fundamental to fisheries management and research. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Methanol extracts of wood from Pinus resinosa were found to be selectively cytotoxic against human lung carcinoma cells, A549 (IC50 41 +/- 6 microg/mL), human colorectal adenocarcinoma cells, DLD-1 (IC50 47 +/- 4 microg/mL) in comparison with healthy cells, WS1 (IC50 130 +/- 11 microg/mL). Five known compounds were isolated and identified by 1H, 13C NMRspectroscopy and HR-ESI-MS mass spectrometry as, pinosylvin monomethyl ether (1), pinosylvin (2), pinosylvin dimethyl ether (3), pinobanksin (4) and (-)-norachelogenin (5). Compound 4 was isolated for the first time in P. resinosa. The cytotoxicity of compounds 1-5 was evaluated against A549, DLD-1 and WS1. Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 +/- 4 microm for A549, 20 +/- 1 microm for DLD-1 and 34 +/- 3 microm for WS1. [ABSTRACT FROM AUTHOR]

Providing care to a friend or relative suffering from a mental health problem can affect the physical and mental health of the caregiver. In the Montreal Mental Health Survey, 405 caregivers of people suffering from such problems took part in a mail survey about their experiences. The goal of this article is to describe these caregiving experiences and to identify their predictors. Results show that seriousness of the care recipient's problem is a predictor of a negative caregiving appraisal, but much less so of a positive one. The caregiving context is decisive in relation to both the positive and negative aspects of the experience. A strong correlation is observed between the positive and negative aspects of the scale, indicating that the caregiving experience is not one-dimensional. On the contrary, it can be simultaneously burdensome and satisfying. [ABSTRACT FROM AUTHOR]

The radiology information system (RIS) provides patient and examination information that is used in setting up and performing a radiologic procedure. In a digital imaging environment, information from the RIS can also be used to populate fields in the Digital Imaging and Communications in Medicine (DICOM) image header. Ideally, information from the RIS should be available at the modality at the time of the examination, and automatically be attached to the image in the appropriate DICOM fields before storage in the picture archiving and communications system (PACS). We have designed a highly integrated RIS interface for a digital radiography (DR) system. This interface employs browser technology to make RIS information conveniently available at the modality, and DICOM modality performed procedure step (MPPS) for RIS/DR information exchange. A novel feature of our approach is that a single display screen at the modality is used to alternatively display either the modality control window or the RIS window. Full access to RIS capabilities is available at the modality, including worklists and prior reports. Copyright (c) 1999 by W.B. Saunders Company [ABSTRACT FROM AUTHOR]

Abstract Background The peptidyl-prolyl isomerase Pin1 recently revealed itself as a new player in the regulation of protein function by phosphorylation. Pin1 isomerizes the peptide bond of specific phosphorylated serine or threonine residues preceding proline in several proteins involved in various cellular events including mitosis, transcription, differentiation and DNA damage response. Many Pin1 substrates are antigens of the phosphodependent monoclonal antibody MPM-2, which reacts with a subset of proteins phosphorylated at the G2/M transition. Results As MPM-2 is not a general marker of mitotic phosphoproteins, and as most mitotic substrates are phosphorylated more than once, we used a different phosphodependent antibody, mAb CC-3, to identify additional mitotic phosphoproteins and eventual Pin1 substrates by combining affinity purification, MALDI-TOF mass spectrometry and immunoblotting. Most CC-3-reactive phosphoproteins appeared to be known or novel MPM-2 antigens and included the RNA-binding protein p54nrb/nmt55, the spliceosomal protein SAP155, the Ki-67 antigen, MAP-1B, DNA topoisomerases II α and β, the elongation factor hSpt5 and the largest subunit of RNA polymerase II. The CC-3 mitotic antigens were also shown to be Pin1 targets. The fine CC-3- and MPM-2-epitope mapping of the RNA polymerase II carboxy-terminal domain confirmed that the epitopes were different and could be generated in vitro by distinct kinases. Finally, the post-mitotic dephosphorylation of both CC-3 and MPM-2 antigens was prevented when cellular Pin1 activity was blocked by the selective inhibitor juglone. Conclusion These observations indicate that the mitotic phosphoproteins associated with Pin1 are phosphorylated on multiple sites, suggesting combinatorial regulation of substrate recognition and isomerization.

Background Self-monitoring biases and overconfidence in incorrect judgments have been suggested as playing a role in schizophrenia spectrum disorders. Little is known about whether self-monitoring biases may contribute to early risk factors for psychosis. In this study, action self-monitoring (i.e., discrimination between imagined and performed actions) was investigated, along with confidence in judgments among ultra-high risk (UHR) for psychosis individuals and first-episode psychosis (FEP) patients. Methods Thirty-six UHR for psychosis individuals, 25 FEP patients and 33 healthy controls (CON) participated in the study. Participants were assessed with the Action memory task. Simple actions were presented to participants verbally or non-verbally. Some actions were required to be physically performed and others were imagined. Participants were asked whether the action was presented verbally or non-verbally (action presentation type discrimination), and whether the action was performed or imagined (self-monitoring). Confidence self-ratings related to self-monitoring responses were obtained. Results The analysis of self-monitoring revealed that both UHR and FEP groups misattributed imagined actions as being performed (i.e., self-monitoring errors) significantly more often than the CON group. There were no differences regarding performed actions as being imagined. UHR and FEP groups made their false responses with higher confidence in their judgments than the CON group. There were no group differences regarding discrimination between the types of actions presented (verbal vs non-verbal). Conclusions A specific type of self-monitoring bias (i.e., misattributing imagined actions with performed actions), accompanied by high confidence in this judgment, may be a risk factor for the subsequent development of a psychotic disorder. [ABSTRACT FROM AUTHOR]

Phenomenological research indicates that disturbance of the basic sense of self may be a core phenotypic marker of schizophrenia spectrum disorders. Basic self-disturbance refers to disruption of the sense of ownership of experience and agency of action and is associated with a variety of anomalous subjective experiences. Little is known about the neurocognitive underpinnings of basic self-disturbance. In these two theoretical papers (of which this is Part 2), we review some recent phenomenological and neurocognitive research and point to a convergence of these approaches around the concept of self-disturbance. Specifically, we propose that subjective anomalies associated with basic self-disturbance may be associated with: 1. source monitoring deficits, which may contribute particularly to disturbances of "ownership" and "mineness" (the phenomenological notion of presence or self-affection) and 2. aberrant salience, and associated disturbances of memory, prediction and attention processes, which may contribute to hyper-reflexivity, disturbed "grip" or "hold" on perceptual and conceptual fields, and disturbances of intuitive social understanding ("common sense"). In this paper (Part 2) we focus on aberrant salience. Part 1 (this issue) addressed source monitoring deficits. Empirical studies are required in a variety of populations in order to test these proposed associations between phenomenological and neurocognitive aspects of self-disturbance in schizophrenia. An integration of findings across the phenomenological and neurocognitive "levels" would represent a significant advance in the understanding of schizophrenia and possibly enhance early identification and intervention strategies. [ABSTRACT FROM AUTHOR]

Abstract: Phenomenological research indicates that disturbance of the basic sense of self may be a core phenotypic marker of schizophrenia spectrum disorders. Basic self-disturbance refers to disruption of the sense of ownership of experience and agency of action and is associated with a variety of anomalous subjective experiences. Little is known about the neurocognitive underpinnings of basic self-disturbance. In these two theoretical papers (of which this is Part 1), we review some recent phenomenological and neurocognitive research and point to a convergence of these approaches around the concept of self-disturbance. Specifically, we propose that subjective anomalies associated with basic self-disturbance may be associated with: 1. source monitoring deficits, which may contribute particularly to disturbances of “ownership” and “mineness” (the phenomenological notion of presence or self-affection) and 2. aberrant salience, and associated disturbances of memory, prediction and attention processes, which may contribute to hyper-reflexivity, disturbed “grip” or “hold” on the perceptual and conceptual field, and disturbances of intuitive social understanding (“common sense”). In this paper (Part 1) we focus on source monitoring deficits. Part 2 (this issue) addresses aberrant salience. Empirical studies are required in a variety of populations in order to test these proposed associations between phenomenological and neurocognitive aspects of self-disturbance in schizophrenia. An integration of findings across the phenomenological and neurocognitive “levels” would represent a significant advance in the understanding of schizophrenia and possibly enhance early identification and intervention strategies. [Copyright &y& Elsevier]

There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in patients identified using the 'ultra high risk' (UHR) for psychosis approach. The current study investigated whether basic symptoms, specifically cognitive disturbances (COGDIS), were associated with a greater risk of transition to psychotic disorder and persistent attenuated psychotic symptoms (APS) at medium term follow-up (mean = 3.4 years) in UHR patients, as well as with general psychopathology at baseline. The sample included 304 UHR participants (mean age = 19.12 years) involved in an international multicenter trial of omega-3 fatty acids. UHR individuals who also met the COGDIS criteria (basic symptoms risk criteria) did not have a greater risk of transition than those who met the UHR criteria alone. However, meeting COGDIS risk criteria was associated with a greater likelihood of meeting the UHR attenuated psychotic symptoms risk group (i.e., having persistent attenuated psychotic symptoms) at 12-month follow-up (odds ratio = 1.85; 95% CI = 1.03, 3.32). Greater severity of cognitive basic symptoms was also independently associated with more severe general psychopathology at study entry. The findings do not support the notion that combined risk identification approaches (UHR and basic symptoms) aid in the identification of individuals at greatest risk of psychosis, although this interpretation is limited by the modest transition to psychosis rate (13%) and the time of follow up. However, the findings indicate that basic symptoms may be a clinically useful marker of more severe general psychopathology in UHR groups and risk for persistent attenuated psychotic symptoms. [ABSTRACT FROM AUTHOR]